Traditional Chinese medicine composition for improving sleep quality of menopausal women and preparation method thereof

The invention discloses traditional Chinese medicine decoction for improving sleep quality of menopausal women. The traditional Chinese medicine decoction is prepared from the following main raw materials in parts by weight: 8-12 parts of semen cuscutae, 5-12 parts of ligusticum wallichii, 12-18 parts of calcined oyster shell, 8-16 parts of radix paeoniae alba, 8-16 parts of herba epimedii, 8-16 parts of uncaria, 6-12 parts of leonurus, 6-12 parts of scutellaria baicalensis, 4-9 parts of fried jujube kernel, 3-9 parts of cassia twig, 3-9 parts of licorice, 4-9 parts of golden cypress, 3-9 parts of schisandra chinensis, 3-8 parts of herba lycopi, 2-5 parts of divaricate saposhnikovia root and 4-9 parts of radix angelicae. The traditional Chinese medicine decoction disclosed by the invention has a good effect of improving the sleep quality of the menopausal women, has the functions of calming the heart and tranquilizing the mind, relieving annoy and promoting sleep, and is remarkable in curative ...

Levosimendan for injection and preparation method thereof

The invention belongs to the field of pharmaceutical preparations, and provides levosimendan for injection and a preparation method thereof.The levosimendan for injection comprises levosimendan serving as an active ingredient, povidone, a cosolvent, a freeze-drying protective agent and a dilution stabilizer, the composition does not contain ethyl alcohol, and the composition is redissolved, diluted and administered through intravenous drip with a 0.9% sodium chloride injection or a 5% glucose injection. The irritation of ethanol to blood vessels can be avoided; the adopted special dilution stabilizer can remarkably improve the stability of the compatible solution, so that the medication safety is remarkably improved. The composition can be stored below 25 DEG C, and is convenient to transport and clinically apply. The preparation process of the levosimendan for injection is simple, adopts degerming, filtering and freeze-drying processes, and is suitable for industrial production.

Traditional Chinese medicine suppository for treating metrorrhagia and metrostaxis, and preparation method thereof

The invention discloses a traditional Chinese medicine suppository for treating metrorrhagia and metrostaxis, which is prepared by the following main raw materials in parts by weight: 2-6 parts of raw sabinene, 4-9 parts of radix sophorae flavescentis, 8-20 parts of chinese osbeckia, 3-9 parts of fructus malvae, 4-9 parts of cuttlefish bone, 3-9 parts of fructus cnidii, 0.5-1.2 parts of red upborne elixir, 9-12 parts of fructus leonuri, and 30-60 parts of oleum sesami. The traditional Chinese medicine suppository has the effects of invigorating qi and blood, activating the blood circulation to dispel blood stasis, as well as stopping bleeding and regulating menstruation, and has a good treatment effect on the metrorrhagia and metrostaxis; the dosage form is suppository which can play local roles in lubricating, antibiosis, insect killing, convergence, pain stopping, itching relieving and other local roles in an orifice, and can also avoid the stimulation of drug on a gastric mucosa, and ...

Polyglycerol fatty acid ester derivative of hydroxycamptothecine

The invention relates to a polyglycerol fatty acid ester derivative of hydroxycamptothecine. The polyglycerol fatty acid ester derivative is characterized by being of a structure that polyglyceryl fatty acid and hydroxyl on a 10th position of the hydroxycamptothecine form ester. The invention describes a structure characteristic, a conventional preparation method and an application of the polyglycerol fatty acid ester derivative in the aspect of anti-tumor medicines.

Traditional Chinese medicinal suppository for treating cervicitis and preparation method thereof

The invention discloses a traditional Chinese medicinal suppository for treating cervicitis. The traditional Chinese medicinal suppository for treating the cervicitis is mainly prepared from the following raw materials in parts by weight: 3-9 parts of stemona, 4-9 parts of sophora flavescens, 10-20 parts of herba houttuyniae, 3-9 parts of cluster mallow fruit, 5-9 parts of lithospermum, 3-9 parts of fructus cnidii, 0.5-2 parts of alum (calcined), 9-20 parts of plantain herb and 30-60 parts of sesame oil. The traditional Chinese medicinal suppository for treating the cervicitis has the effects of diminishing inflammation, subduing swelling, clearing away heat and toxic materials and has a good treatment effect on the cervicitis.

Xinafolic acid pramipexole sustained-release microsphere as well as preparation method and application thereof

The invention provides a pramipexole xinafoate microsphere composition and a preparation method thereof, the composition comprises pramipexole xinafoate microspheres and a special solvent, and the microspheres comprise pramipexole xinafoate and a lactide-glycolide copolymer. The pramipexole xinafoate microsphere has no obvious release delay period or burst release phenomenon after administration, has good slow release performance, can maintain stable treatment blood concentration within several weeks or more, has good stability, and can still maintain the release behavior after long-time storage. In addition, the microsphere provided by the invention is simple and convenient in preparation process and easy to industrially amplify.

Traditional Chinese medicine suppository for treating cervical polyp and preparation method thereof

The invention discloses traditional Chinese medicine suppository for treating cervical polyp and a preparation method thereof. The traditional Chinese medicine suppository is prepared by, by weight, main raw materials including 5 parts of Chinese trumpet creeper, 4 parts of Chinese sage herb, 14 parts of houttuynia cordata, 5 parts of cluster mallow fruits, 6 parts of lithospermum, 4 parts of schizonepeta, 1 part of elephantopus scaber, 10 parts of gerbera and 40 parts of sesame oil. The traditional Chinese medicine suppository has the effects of eliminating dampness, arresting leucorrhea and killing parasites to relieve itching and has remarkable treating effect on cervical polyp. The traditional Chinese medicine suppository is prepared completely according to a theory of treating cervical polyp by adopting traditional Chinese medicine, selected medical material resources are easy to obtain, cost is low, and economical burden is not brought to a patient.

Traditional Chinese Medicine (TCM) suppository for treating cervical polyp and preparation method thereof

The invention discloses a Traditional Chinese Medicine (TCM) suppository for treating cervical polyp and a preparation method thereof. The TCM suppository is prepared from the following main components in parts by weight: 3-9 parts of Chinese trumpetcreeper flower, 3-9 parts of salvia chinensis, 10-20 parts of houttuynia cordata, 3-9 parts of cluster mallow fruit, 5-9 parts of radix lithospermi, 3-6 parts of schizonepeta, 0.5-2 parts of elephantopus scaber, 9-15 parts of gerbera and 30-60 parts of sesame oil. The TCM suppository disclosed by the invention has the effects on eliminating dampness and arresting leucorrhea and killing parasites to relieve itching, has a significant curative effect on cervical polyp, and is developed completely according to the TCM theory for treating cervical polyp; the medicine sources of the TCM suppository are easy to obtain and low in cost so as not to bring economical burden to patients.

Novel long-circulating liposome composition and preparation method thereof

The invention relates to a novel long-circulating liposome composition and an application method thereof. The long-circulating liposome composition is mainly prepared from phospholipid, cholesterol, an electronegative material and a long-circulating material serving as main raw materials, wherein tocopheryl acetate succinate or cholesterol succinate is used as the electronegative material particularly, and tocopheryl acetate polyethylene glycol succinate (TPGS) is used as the long-circulating material particularly, so that the stability of combining the long-circulating liposome composition and medicaments is improved; the long-circulating liposome composition can be used as a carrier of anti-tumor medicaments such as paclitaxel, docetaxel and 10-hydroxycamptothecine, and simultaneously, the tolerance is improved; and when the long-circulating liposome composition is used as the medicinal carrier, the circulating time of the carried medicaments in vivo is longer than that of various carriers ...

Method for industrially preparing sodium alginate micro-capsule loading high-density cells

The present invention discloses a method for industrially preparing sodium alginate micro-capsule loading high-density cells, which is a method for preparing the sodium alginate micro-capsule and packing cells by using sodium alginate-polylysine or chitosan-sodium alginate as a composite packing material through a vibrating nozzle method. The method increases the concentration of the sodium alginate to 1.5-5% in the preparation process of the sodium alginate micro-capsule and adds a surfactant into the curing solution of the micro-capsule so as to enhance the cell packing density in the sodium alginate micro-capsule and improve the shape of the micro-capsule and the particle size distribution. The method is capable of obviously enhancing the density of the cells in the sodium alginate micro-capsule and improving the shape of the micro-capsule, has uniform particle size distribution of the micro-capsule and improves production efficiency so as to meet the requirements of the micro-capsule ...

Method for industrially preparing sodium alginate micro-capsule loading high-density cells

The invention discloses a method for industrially preparing sodium alginate micro-capsule loading high-density cells, which is a method for preparing the sodium alginate micro-capsule and packing cells by using sodium alginate-polylysine or chitosan-sodium alginate as a composite packing material through a vibrating nozzle method. The method increases the concentration of the sodium alginate to 1.5-5% in the preparation process of the sodium alginate micro-capsule and adds a surfactant into the curing solution of the micro-capsule so as to enhance the cell packing density in the sodium alginate micro-capsule and improve the shape of the micro-capsule and the particle size distribution. The method is capable of obviously enhancing the density of the cells in the sodium alginate micro-capsule and improving the shape of the micro-capsule, has uniform particle size distribution of the micro-capsule and improves production efficiency so as to meet the requirements of the micro-capsule on industrial ...

Butylphthalide nano-liposome freeze-dried powder injection and preparation method thereof

The invention relates to the field of medicines, in particular to a nano-liposome and a preparation method thereof. In particular, the invention relates to a butylphthalide nano-liposome powder injection for treating acute ischemic stroke and a preparation method thereof. The nano-liposome is mainly composed of butylphthalide or L-butylphthalide, phospholipid, cholesterol, a long circulating material, a negative charge material, a protective agent and a pH regulator. The butylphthalide nano-liposome is prepared by adopting a film dispersion method and a mixing cavity preparation method, and the mixing cavity technology is easier to realize linear amplification and is more suitable for amplifying the production scale. According to the invention, lipidosome inclusion solubilization is adopted, the use of sulfobutyl-beta-cyclodextrin and other types of cyclodextrin is completely abandoned, the toxic and side effects are reduced, the therapeutic index is improved, and the medication safety ...

Traditional Chinese medicine suppository for treating cervical erosion and preparation method thereof

The invention discloses a traditional Chinese medicine suppository for treating cervical erosion. The traditional Chinese medicine suppository is prepared by comprising the following main materials in parts by weight: 3-6 parts of purslane, 4-9 parts of ophora flavescens, 10-20 parts of houttuynia cordata, 3-9 parts of cluster mallow fruits, 5-9 parts of lithospermum, 2-6.5 parts of motherwort fruits, 0.5-1.5 parts of halloysitum rubrum, 9-20 parts of plantain herb and 30-60 parts of sesame oil. The traditional Chinese medicine suppository disclosed by the invention is prepared by refereeing to modern medical research results on the basis of understanding and treatment principle of traditional Chinese medicine on cervical erosion pathogenesis, has effects of inducing astringency and relieving itching, clearing away heat and toxic materials, and clearing away heat and drying dampness, so that a purpose of completely treating cervical erosion is achieved.

Galanthamine long-acting release injectable microsphere composite and preparation method thereof

The invention discloses galanthamine microspheres which contain 5-40wt% of basic group of galanthamine and 60-95wt % of polylactic acid/hydroxyacetic acid copolymer. The invention also provides a galanthamine long-acting release injectable microsphere composite which comprises the following components by weight percent: 60-90% of galanthamine microspheres, 5-25% of frozen dry proppant, 0.5-5% of suspending agent, 0.5-5% of wetting agent and 1-25% of osmotic pressure regulator. The invention combines the vibration nozzle method with the emulsion process (O/W)-solvent evaporation method so that the method has the advantage that the droplet-generating speed is fast, the efficiency is high, the containers used in preparation are easy to use in the aseptic operation, the production process can be carried out continuously, the technology is applicable to scale-up application, etc.

Method for preparing traditional Chinese medicine suppositories for treating cervical polyp

The invention discloses a method for preparing traditional Chinese medicine suppositories for treating cervical polyp. The traditional Chinese medicine suppositories comprise, by weight, 9 parts of Chinese trumpet creeper, 9 parts of salvia chinensis, 20 parts of herba houttuyniae, 9 parts of fructus malvae vertillatae, 9 parts of lithospermum, 6 parts of herba schizonepetae, 2 parts of meloe coarctatus, 15 parts of gerbera and 60 parts of sesame oil. The traditional Chinese medicine suppositories have the function of drying wet, checking vaginal discharge, killing worms and relieving itching, have remarkable treatment effect on cervical polyp, and are completely developed according to the theory for treating cervical polyp through traditional Chinese medicine, the medicinal herbs resources of the selected traditional Chinese medicine are easy to obtain, cost is low, and economical burden cannot be brought to patients.

Method for preparing ethylsulfonyl acetonitrile

The invention discloses a method for preparing ethylsulfonyl acetonitrile. In the method, a potassium monopersulfate complex is taken as an oxidant, quaternary ammonium salt is taken as a catalyst, and ethylthio acetonitrile is oxidized into the ethylsulfonyl acetonitrile in an aqueous phase. The reaction conditions are mild, the method is easy and convenient to operate and easy to control, an organic solvent is not needed to be used in the reaction process, the product yield and content are high, and the method is suitable for industrial production.

Preparation method of 2-chloro-3-aminopyridine

The invention belongs to the field of fine chemical industry, and particularly relates to a preparation method of 2-chloro-3-aminopyridine. The method comprises the following steps: adding 2-chloro-3-nitropyridine into water, and dropwisely adding a sodium sulfide water solution to carry out reaction; after the reaction finishes, cooling to precipitate a solid, adding dilute hydrochloric acid to dissolve the solid, filtering, regulating the pH value of the filtrate to 9-10 with an NaOH water solution, and precipitating crystals, thereby obtaining the 2-chloro-3-aminopyridine. The preparation method of 2-chloro-3-aminopyridine has the advantages of mild reaction, high product yield and the like, is simple to operate, and is suitable for industrial production; no organic solvent is used in the reaction process, thereby being beneficial to clean production; and the raw materials are cheap and accessible, thereby lowering the production cost.

Suppository for treating cervical hypertrophy and preparation method thereof

The invention discloses a suppository for treating cervical hypertrophy, which is prepared from the following main raw materials in parts by weight: 3-9 parts of radix stemonae, 4-9 parts of radix sophorae flavescentis, 10-20 parts of cordate houttuynia, 4-6 parts of artemisia anomala, 4-6 parts of hydrargyrum oxydatum crudum, 3-9 parts of fructus cnidii, 1-2 parts of red halloysite, 6-12 parts of semen plantaginis, and 30-60 parts of sesame oil. The suppository disclosed by the invention has the effects of clearing heat, detoxifying, sterilizing and relieving itching; furthermore, the medicinal materials are selected according to the theories of traditional Chinese medicals for treating cervical hypertrophy; the suppository disclosed by the invention is obvious in curative effect and safer and more reliable.

Traditional Chinese medicine composition for treating women's climacteric syndrome and preparation method of traditional Chinese medicine composition

The invention discloses a traditional Chinese medicine composition for treating women's climacteric syndrome. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: 20-45 parts of light wheat, 12-18 parts of calcined keel, 12-18 parts of calcined oyster shell, 8-16 parts of white paeony root, 8-16 parts of herba epimedii, 8-16 parts of uncaria, 6-12 parts of radix bupleuri, 6-12 parts of scutellaria baicalensis, 6-12 parts of Angelica sinensis, 3-9 parts of cassia twig, 3-9 parts of liquorice, 4-9 parts of golden cypress, 3-9 parts of schisandra chinensis, 5-12 parts of moutan bark and 2-5 parts of carbonized hair. The traditional Chinese medicine composition has an obvious effect on the women's climacteric syndrome, has the effects of calming heart and soothing nerves, regulating thoroughfare and conception vessels, nourishing yin and moistening dryness, relieving restlessness and dispeling melancholy and invigorating the spleen ...

Stable liposome composition

Hydroxycamptothecine long-circulating liposome

The invention discloses a hydroxycamptothecine long-circulating liposome and a preparation method thereof. The hydroxycamptothecine long-circulating liposome is prepared from the following components in parts by weight: 1 part of hydroxycamptothecine, 5-30 parts of phospholipid, 1-5 parts of cholesterol, 1-20 parts of TPGS (tocopherol polyethylene glycol succinate), 1-8 parts of poloxamer188. The hydroxycamptothecine long-circulating liposome prepared by the method is proper in grain diameter, high in encapsulation, low in raw material price and simple in process, and is suitable for industrial production.

Galanthamine long-acting release injectable microsphere composite and preparation method thereof

The invention discloses galanthamine microspheres which contain 5-40wt% of basic group of galanthamine and 60-95wt % of polylactic acid/hydroxyacetic acid copolymer. The invention also provides a galanthamine long-acting release injectable microsphere composite which comprises the following components by weight percent: 60-90% of galanthamine microspheres, 5-25% of frozen dry proppant, 0.5-5% of suspending agent, 0.5-5% of wetting agent and 1-25% of osmotic pressure regulator. The invention combines the vibration nozzle method with the emulsion process (O/W)-solvent evaporation method so thatthe method has the advantage that the droplet-generating speed is fast, the efficiency is high, the containers used in preparation are easy to use in the aseptic operation, the production process canbe carried out continuously, the technology is applicable to scale-up application, etc.

Method for preventing cell-carrying sodium alginate microcapsule from shrinking

The invention discloses a method for preventing a sscell-carrying sodium alginate microcapsule from shrinking, which is a method for preparing the sodium alginate microcapsule wrapping cells by using sodium alginate-polylysine or chitosan-sodium alginate as compound wrapping materials. The method is characterized in that a polyol solution is adopted to treat calcium alginate microballoons in the preparing process of the sodium alginate microcapsule, thereby preventing the prepared sodium alginate microcapsule from shrinking.

High-durability modified asphalt and preparation method thereof as well as waterproof coiled material and preparation method thereof

The invention provides high-durability modified asphalt and a preparation method thereof as well as a waterproof coiled material and a preparation method thereof. The high-durability modified asphalt comprises the following components in parts by weight: 60-80 parts of petroleum asphalt; 5 to 15 parts of star-shaped SBS (styrene butadiene styrene); 5-20 parts of mineral asphalt; 0.5-5 parts of an auxiliary agent; and 8-20 parts of an inorganic filler. The mineral asphalt and the star-shaped SBS with the molecular weight of 200000-250000 are matched for use, so that the segregation problem of SBS and other polymer modifiers is solved, and the modified asphalt has the characteristics of high stability and durability.

Method for preventing cell-carrying sodium alginate microcapsule from shrinking

The invention discloses a method for preventing a sscell-carrying sodium alginate microcapsule from shrinking, which is a method for preparing the sodium alginate microcapsule wrapping cells by using sodium alginate-polylysine or chitosan-sodium alginate as compound wrapping materials. The method is characterized in that a polyol solution is adopted to treat calcium alginate microballoons in the preparing process of the sodium alginate microcapsule, thereby preventing the prepared sodium alginate microcapsule from shrinking.

Novel long-circulating liposome composition and preparation method thereof

Traditional Chinese medicine composition for improving irregular menstruation symptom of menopause women and preparation method of traditional Chinese medicine composition

The invention discloses a traditional Chinese medicine composition for improving irregular menstruation symptom of menopause women. The traditional Chinese medicine composition is prepared from the main raw materials in parts by weight: 20-45 parts of light wheat, 12-18 parts of calcined keel, 12-18 parts of calcined oyster shell, 4-12 parts of Ligusticum wallichii, 8-16 parts of herba epimedii, 8-16 parts of uncaria, 6-12 parts of radix bupleuri, 2-4 parts of gastrodia elata, 6-12 parts of angelica sinensis, 3-9 parts of cassia twig, 3-9 parts of liquorice, 4-9 parts of golden cypress, 2-6 parts of pawpaw, 5-9 parts of rhizoma anemarrhenae, 2-5 parts of carbonized hair and 3-6 parts of lalang grass rhizome. The traditional Chinese medicine composition has the effects of maintaining ovary and regulating menstruation and tonifying kidney and nourishing yin and has a good treatment effect of improving irregular menstruation symptom of menopause women.

Nimodipine micelle injection and preparation method thereof

The invention belongs to the field of medicines, provides a nimodipine micelle injection and a preparation method thereof, and particularly relates to a high-concentration nimodipine micelle injection for intravenous drip, which is composed of an active component nimodipine and auxiliary materials such as phospholipid, cholic acid or salt thereof, a surface modification material, an isoosmotic adjusting agent, a pH adjusting agent and water for injection. According to the injection, the solubility of nimodipine is greatly improved, phospholipid and cholic acid which are physiologically compatible as auxiliary materials and a micelle system with good safety are selected for solubilization, an innovative film dispersion-hydration process is adopted, and ethanol is abandoned as a solubilizer in a prescription, so that the medication safety is remarkably improved. The injection can be directly diluted by the injection, the stability of the compatible solution is good within 24 hours, special ...

Votioxetine xinaphthoate crystal form A and preparation method and application thereof

The invention provides a crystal form A of vothioxetine xinaphthoate (1-[2-(2, 4-dimethyl phenyl sulfenyl) phenyl] piperazine 1-hydroxy-2-naphthoic acid) and a preparation method of the crystal form A. The invention further provides a preparation method of the crystal form A of the vothioxetine xinaphthoate. The invention also provides a pharmaceutical composition comprising the crystal form and application of the pharmaceutical composition in medicine preparation. According to the invention, the orally disintegrating tablet is prepared from the vothioxetine xinaphthenate, and the solubility of the vothioxetine xinaphthenate in the oral cavity is reduced while the vothioxetine xinaphthenate is rapidly disintegrated and released, so that the vothioxetine xinaphthenate does not reach a taste bud threshold value, and And the operation is simple, and industrialization is easy to realize.

Linagliptin long-acting sustained-release microsphere and preparation method thereof

The invention discloses a linagliptin long-acting sustained-release microsphere and a preparation process thereof. The linagliptin long-acting sustained-release microspheres are prepared by adopting an emulsification-solvent evaporation method (O/W), and the method is simple in preparation process and easy to amplify. The prepared microspheres are good in safety, high in drug loading capacity and encapsulation efficiency, uniform in particle size distribution, smooth in surface, capable of being continuously and stably released for a long time and free of obvious burst release.