27-11-2013 дата публикации
Номер: CN103409809A
Принадлежит:
The present invention discloses a small molecule drug screening chip, a construction method and an application thereof. The small molecule drug screening chip comprises a substrate layer, a surface modification layer generated through carrying out surface modification on the substrate layer, and small molecules non-selectively absorbed on the surface modification layer. The construction method comprises: carrying out surface modification on a substrate layer of a chip to produce a surface modification layer, such that small molecules are non-selectively absorbed on the surface modification layer. With the method, non-selective effective immobilization of most of small molecules can be achieved, no damage on the inherent structure of small molecules can be achieved as far as possible, and characteristics of large small molecule immobilization amount, high activity and the like can be achieved. The small molecule drug screening chip can be used for detection of interaction between small molecules ...
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