СПОСОБ ЛЕЧЕНИЯ СПАЕЧНОЙ БОЛЕЗНИ

Изобретение относится к медицине, хирургии, может быть использовано для лечения спаечной болезни. Интубируют кишку зондом. Укладывают петли кишки в горизонтальном положении. Фиксируют петли микроирригаторами с трефинационными отверстиями. Микроирригаторы проведены по проводникам через брыжейку кишки под pars nuda. Концы микроирригаторов оставляют вне брюшной полости. Потенцируют спаечный процесс между петлями кишок. Для чего проводят механическую и химическую десквамацию мезотелия брюшинного покрова брыжейки. В послеоперационном периоде через микроирригаторы вводят растворы эпсилонаминокапроновой кислоты в дозе 20-25 мл 3 раза в сутки первые двое суток. В течение последующих 3-5 суток через микроирригаторы вводят контринал в дозе 2500-5000 ЕD на 20-25 мл изотонического раствора хлорида натрия 3 раза в сутки. Способ позволяет контролировать образование внутрибрюшных спаек.

СУЛЬФОНАМИДЗАМЕЩЕННЫЕ АННЕЛИРОВАННЫЕ СЕМИЧЛЕННЫЕ ЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННОГО СРЕДСТВА, А ТАКЖЕ СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ

Изобретение относится к сульфонамидзамещенным аннелированным семичленным циклическим соединениям формулы (1) где Х(1) означает -О- или -СН2-; Х(2) и Х(3) означают -СН2 -; Х(4) означает -СН2- или -CHOH-; Y(1), Y(2), Y(3) и Y(4) независимо друг от друга означают -CR(12)-; R(12) независимо друг от друга означают водород, F, Cl, Br, J; (С1-С5)-алкил, CN, NO2, -Z-CmH2m-R(13); Z означает О или CONR(14); R(14) означает водород или(С1-С3)-алкил; m означает 0, 1, 2, 3, 4 или 5; R(13) означает водород или фенил незамещенный или замещенный метоксигруппой, R(3) означает Р(17)-СхН2х, x = 1, 2, 3, 4, 5, где R(17) означает водород; или R(3) означает фенил, незамещенный или замещенный 1 или 2 заместителями, выбранными из группы, включающей F, Cl, Вr, (С1-С2)-алкил или метоксигруппу; R(4) означает водород или R(20)-CrH2r, r=1, 2, 3, 4, 5, 6; R(20) означает водород; R(5) означает водород, во всех их стереоизомерных формах и в виде их смесей в любых соотношениях, а также их физиологически приемлемые соли.

АРОМАТИЧЕСКАЯ СУЛЬФОНГИДРОКСАМОВАЯ КИСЛОТА В КАЧЕСТВЕ ИНГИБИТОРА МЕТАЛЛОПРОТЕАЗ

Изобретение относится к области медицины и касается способа лечения заболеваний, связанных с патологической активностью матриксных металлопротеаз, с помощью соединений формулы I, соединений формулы I, а также способа получения указанных соединений. Изобретение повышает эффективность лечения. 25 с. и 111 з.п. ф-лы, 152 табл.

ЗАМЕЩЕННЫЕ ЦИКЛОАЛКЕНОВЫЕ ПРОИЗВОДНЫЕ

Изобретение относится к новым замещенным циклоалкеновым производным формулы (I) ! ! в которой X и Y представляют собой группу, в которой Х и Y вместе с атомом углерода кольца В, к которому они присоединены, образуют кольцо А, Х и Y вместе представляют заместитель кольца В или Х и Y каждый представляет собой атом водорода. ! Изобретение также относится к лекарственному средству на основе этих соединений, обладающему подавляющим действием в отношении внутриклеточной сигнальной трансдукции или активации клеток, индуцируемой эндотоксином. 2 н. и 19 з.п. ф-лы., 3 табл.

Способ получения производных тиоформамида

СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВО НЫХ ТИОФОРМАМИДА общей формулы 1 -х- Het где R - водород или С -С алкил, tlet - 3-пиридил, 4-пирйдш1, пир зинил, пнразинил или хино X - сера или кислород, У - сера, кислород-, валентная связь или метилен; ЕНИЯ .. или Het - 2-пиридил X - сера или кислород; У - сера, кислород или метилен; или Het - 2-пиридил, X - кислород; У валентная связь, от л и ч а ю щ и и с я тем, что сложный дитиоэфир формулы II , . --sr- NHei где Het, X и у имеют указанные значения; R - С -С -алкил, бензил или карбоксимётил, подвергают взаимодействию с избытком амина формулы III : К-БНг где R - имеет указанные значения, в органическом растворителе при 20-40amp;deg;С.

Способ получения 5-(4-гидрокси-3,5-ди-трет-бутилфенил)-метилентиазолидинона-4 или его производных

ИЗОБРЕТЕНИЕ КАСАЕТСЯ ГЕТЕРОЦИКЛИЧЕСКИХ СОЕДИНЕНИЙ, В ЧАСТНОСТИ СПОСОБОВ ПОЛУЧЕНИЯ 5-(4-ГИДРОКСИ-3,5-ДИ-ТРЕТ-БУТИЛФЕНИЛ)-МЕТИЛЕНТИАЗОЛИДИНОНА-4 ИЛИ ЕГО ПРОИЗВОДНЫХ ФОРМУЛЫ CH=C[C(CH3)3-C(OH)=C[C(CH3)3]-CH=C-CH=C-C(O)-NR-CH2-S, где R-H, или C1-C4-алкил, обладающих противовоспалительными и противоартритными свойствами, что может быть использовано в медицине. Цель - создание веществ с активностью, не характерной для данного класса. Синтез ведут реакцией 3,5-ди-трет-бутил-4-гидроксибензальдегида с роданином при кипячении в среде ледяной уксусной кислоты в присутствии ацетата щелочного металла. Образующееся соединение восстанавливают триалкилоловогидридом в присутствии азобисизобутиронитрила при кипячении в среде инертного органического растворителя или водородом над палладиевым катализатором под давлением при 50-120°С. Целевой продукт выделяют непосредственно при R-H или его обрабатывают гидридом натрия и соединением формулы: R1-J, где R1-C1-C4-алкил, при кипячении в среде инертного органического ...

Способ получения производных 3-карбалкокси-1-тиаизохроман-1,1-диоксида

IMMUNSUPPRESSIVE UND ANTIALLERGISCHE VERBINDUNGEN; Z.B. N-(3-OXOHEXANOYL)-HOMOSERINLACTON

Thioxanthenon-Antitumormittel.

VERWENDUNG VON 5-FLUORO-2'-DEOXY-3'-THIACYTIDIN ZUR BEHANDLUNG VON HEPATITIS B

PHARMAKOLOGISCH AKTIVE CATECHOLDERIVATE

Substituierte 1,3-Oxathiolane mit antiviraler Wirkung

Verfahren zu Herstellung von halb-synthetischen Statins via neue Zwischenprodukte

Antitumour synergistic composition

CYCLIC ETHER DERIVATIVES

3-(2-HALOALKYL)-1,4-OXATHIINS AND 2-(2-HALOALKYL)-1,4-DITHIINS, AND TREATMENT OF LEUKEMIA AND TUMORS THEREWITH

PHARMACEUTICALS

A composition for the topical treatment of acne

A composition for the topical treatment of acne comprises as active ingredients are a micronized peroxide of an organic acid e.g. benzoyl peroxide and lauroyl peroxide erythromycin or a derivative thereof. A two-part composition has the erythromycin compound in one part and the remaining ingredients in a second part. Also, described is a package having two closable containers, one containing the said erythromycin compound and the other containing the remaining ingredients.

A Composition for the topical treatment of acne

A composition for the topical treatment of acne comprises as active ingredients a peroxide of an organic acid e.g. benzoyl peroxide and lauroyl peroxide and erythromycin or a derivative thereof. A two-part composition has the erythromycin compound in one part and the remaining ingredients in a second part. Also, described is a package having two closable containers, one containing the said erythromycin compound and the other containing the remaining ingredients.

Benzamide analogues

Quarternary bisamonium salt precursors and their uses as prodrugs having an antiparasitic activity

Spiroketone acetyl-COA carboxylase inhibitors

Quaternary Bis-ammonium Salt Precursors And Their Uses As Prodrugs Having An Antiparasitic Activity

The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A', identical or different, are respectively either a group A1 and A'1 of formula (1) wherein n=2 to 4; R'1 is hydrogen, C1-C5 alkyl, optionally substituted by an aryl, a hydroxy, an alkoxy, wherein the alkyl comprises 1 to 5 C, or aryloxy and W is halogen or a nucleofuge group; or a group A2 which represents formly-CHO, or acetyl-COCH3- B and B' , identical or different, represent respectively either the group B1 and B'1, if A and A' respectively represent A1, A'1, B1, B'1 representing a group R1 which has the same definition as R'1 above, but cannot be a hydrogen atom; or respectively the groups B2 and B'2, if A and A' represent A2, B2 or B'2 being the group R1 as defined above, or a group of formula (2) wherein -Ra is RS- or RCO-wherein R is a C1-C6 alkyl, substituted if required, a phenyl or benzyl, wherein the phenyl ...

Substituted:- 1,3-oxathiolanes with antiviral properties.

Disclosed are compounds of the formula ..... wherein r1 is hydrogen; r2 is a purine or pyrimidine base of an analogue or derivative thereof; z is s, s=o or so2; and pharmaceutically acceptable derivatives thereof, also described are use of the compounds as antiviral agents, pharmaceutical formulations, and methods for the preparation of the compounds.

Synergistic combinations of zidovudine, 1592U89 and 3tc or Ftc.

The present invention relates to therapeutic combinations of (is,4r)-cis-4-[2-amino-6-(cyclopropylamino)-9h-purin-9-y1]-2-cyclopentene-1-methanol (1592u89), 3'-azido-3'deoxythymidine (zidovudine) and (2r,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1h)-pyrimidin-2-one (3TC)(or, alternatively to 3TC, (2r,cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1h)-pyrimidin-2-one (ftc)) which have anti-HIVactivity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HIV infections including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.

SUBSTITUTED:1,3 OXATHIOLANES WITH ANTIVIRAL PROPERTIES

Phenoxybenzylamine derivatives as SSRIs.

Acompound of general formula (1)wherein r1 and r2 are h, c1-c6alkyl or(ch2)d(c3-c6cycloalkyl)wherein d=0,1,2 or 3; or r1 and r2 together with the nitrogen to which they are attached form an azetidine ring; z or y is -sr3 and the other z or y is halogen or -r3; wherein r3 is c1-c4 alkyl optionally substituted with fluorine; except that r3 is not cf3; or z and y are linked so that, together with the interconnecting atoms, z and y form fused 5 to 7-membered cabocyclic or heterocyclic ring, and wherein when z and y form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; r4 and r5, which may be the same or different, are: a-x, wherein a= -ch=ch- or -(ch2)p- where p is 0,1 or 2; x is hydrogen,f,cl,br,i,conr6r7,so2nr6r7, so2nhc(=o)r6,oh,c1-4alkoxy, nr8so2r9, no2, nr6r11, cn, co2r10, cho, sr10, s(0)r9, or a 5- or 6-membered heterocyclic ring containing 1,2,or 3 heteroatoms selected from n, s and ...

Synergistic combinations of zidovudine 159U89 and 3TC or FTC

Quarternary bisamonium salt precursors and their uses as prodrugs having an antiparasitic activity

N,N' -substituted-1,3-diamino -2-hydroxypropane derivatives.

Disclosed are compounds of the formula (0, wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasec-retase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

Spiroketone acetyl-COA carboxylase inhibitors

Pharmaceutical composition comprising a SGLT2 inhibitor, a DPP-IV inhibitor and optionally a furtherantidiabetic agent and uses thereof.

New derivatives of the thioformamide and their method of preparation.

"Substituted-1, 3-oxathiolanes with antiviral properties".

New tricyclic ethers, their process of prepation and their use as drug.

Phenoxybenzylamine derivatives as selective seotonin re-uptake inhibitors.

N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives.

Synergistic combinations of zidovudine 1592u89 and3tc or ftc

Antiviral combinations containing nucleoside analogs

“New compounds of the butyric acid 4-amino, their method of preparation and the preparations pharmaceutical which contain them”.

Precursors of seis of (a)-ammonium quatemaire and their applications like pro-drugs having a pest-destroying activity.

Synergistic combinations of zidovudine 159U89 and 3TC or FTC

SUBSTITUTED:1,3 OXATHIOLANES WITH ANTIVIRAL PROPERTIES

Pharmaceutical composition comprising a SGLT2 inhibitor, a DPP-IV inhibitor and optionally a furtherantidiabetic agent and uses thereof.

Quarternary bisamonium salt precursors and their uses as prodrugs having an antiparasitic activity

Spiroketone acetyl-COA carboxylase inhibitors

Pharmaceutical composition comprising a SGLT2 inhibitor, a DPP-IV inhibitor and optionally a furtherantidiabetic agent and uses thereof.

PROCEDURE FOR THE PRODUCTION OF A TOPI, AQUEOUS-ALCOHOLIC GEL COMPOSITION FOR THE TREATMENT OF ACNE

VERFAHREN ZUR HERSTELLUNG EINER TOPISCHEN, WAESSERIG-ALKOHOLISCHEN GELZUSAMMENSETZUNG FUER DIE BEHANDLUNG VON AKNE

SPIROKETONE AS INHIBITORS OF ACETYL COACARBOXYLASE ONES

ARYL-SUBSTITUTED RHODANINDERIVATE

CYCLIC ONE AND ACYCLIC ONE DISULFONSAEUREESTERVERBINDUNG FOR CANCER CHEMOTHERAPY, THEIR USE PROCEDURES AND INTERMEDIATE PRODUCTS.

6H-DIBENZO (B, E) (1,4) OXATHIEPIN CONNECTIONS.

TRICYCLI ETHERS, PROCEDURES FOR YOUR PRODUCTION AND YOUR USE AS DRUGS.

ANTI-CANCER CONNECTIONS.

ALKYLAMINOINDANVERBINDUNGEN, PROCEDURES FOR THEIR PRODUCTION AND THESE CONTAINING PHARMACEUTICAL COMPOSITIONS

SIMILAR ONE OF BENZAMID, TO THE USE AS PARP (ADP RIBOSYLTRANSFERASE ONE, ADPRT) DNS REPAIR ENZYME INHIBITORS

THIOXANTHENON ANTITUMORMITTEL.

AETHER AND THIOAETHER WITH HEILENDER EFFECT, THEIR PRODUCTION AND THESE CONTAINING PHARMACEUTICAL COMPOSITIONS.

BIOLOGICALLY EFFECTIVE ONES, HETEROBICYCLI HYDROXIMIDATE AND THIOLHYDROXIMIDATE AND THEIR CARBAMATESTER DERIVATIVES.

ANTIVIRAL ONE NUCLEOSIDKOMBINATION

SUBSTITUTED GUANIDINE AND DERIVATIVES OF IT AS MODULATORS OF THE RELEASE OF NEUROTRANSMITTERS AND NEW METHOD FOR THE IDENTIFICATION OF INHIBITORS OF THE NEUROTRANSMITTER RELEASE

ACTIVE SUBSTANCE COMBINATIONS WITH INSECTICIDES AND AKARIZIDEN CHARACTERISTICS

DRUG CONTAINING SUBSTITUTED 2-ARYL AMINOESSIGSÄURE CONNECTIONS AND/OR SUBSTITUTED 2-HETEROARYL-AMINOESSIGSÄURE CONNECTIONS

CHINAZOLINE AS CHEMOTHERAPEUTIC AGENTS

BENZAMIDANALOGA TO THE USE AS PARP (ADP RIBOSYLTRANSFERASE, ADPRT) DNS REPARATURENZYM INHIBITORS

PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ALCOHOL CRAZE

USE OF 2,7,8-TRIMETHYL-2 (BETA CARBOXYETHYL) - 6-HYDROXY-CHROMAN (LLU ALPHA)

FROM AN AROMATIC OR HETEROAROMATIC RADICAL BIPHENYLDERIVATE AND THIS CONTAINING PHARMACEUTI AND COSMETIC COMPOSITIONEN SUBSTITUTED

SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE AS INHIBITORS THE RETROVIRALEN THE PROTEASE

PROCEDURE FOR the PRODUCTION OF NEW ONE 3-CARBOXY-1-THIA-ISOCHROMAN-1, 1-DIOXID-DERIVATEN

PROCEDURE FOR the PRODUCTION OF NEW ONE 3-CARBALKOXY-1-THIA-ISOCHROMAN-1,1-DIOXID-DERIVATEN

ANTI-VIRUS EFFECT AND DISSOLUTION OF 2HYDROXYMETHYL-5 (5-FLUOROCYTOSIN-1-YL) - 1,3OXATHIOLANE

PHARMACEUTICAL COMPOSITIONS CONTAINING CS 866 AND INSULIN RESISTANCE IMPROVING AVERAGING AND THEIR USE FOR THE TREATMENT OF ARTERIOSKLEROSE AND XANTHOM

USES AND COMPOSITIONS OF NITRATE STAR AS SEDATIVA

TRYPTASE INHIBITORS

PROCEDURE FOR THE PRODUCTION OF HALFSYNTHETIC STATINEN VIANEUE OF INTERMEDIATE PRODUCTS

PROCEDURE FOR the PRODUCTION OF NEW ONE 3-CARBOXY-1-THIASOCHROMAN-1,1-DIOXID-DERIVATEN

Pharmaceutical formulation of the sodium salt of telmisartan

Method and compositions for the synthesis of BCH-189 and related compounds

Active substance combinations with insecticidal and acaricidal properties

Thiolactones

Synergistic combinations of zidovudine, 1592u89 and 3tc or f tc

NEW 4-AMINOBUTYRIC ACID COMPUNDS PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

SUBSTITUTED DIBENZ-OXA-THIOCINONES, -12-OXIDES AND -12, 12-DIOXIDES, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS

METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF BCH-189 AND RELATED COMPOUNDS

ESTROGEN RECEPTOR MODULATORS

ANTIACNE COMPOSITION

BIOLOGICALLY ACTIVE HETEROCYCLIC HYDROXIMIDATES AND THIOLHYDROXIMIDATES AND CARBAMATE ESTER DERIVATIVES THEREOF

Methods and compositions for mitigating pain

Carbocyclic potassium channel inhibitors

METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF BCH-189 AND RELATED COMPOUNDS

The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the steochemistry at the nucleoside 4' position can be controlled to produce enantiomerically--enriched .beta.-BCH-189 and its analogs.

ANTITHROMBOTIC AND/OR ANTIHYPERTENSIVE COMPOSITIONS

ANTITHROMBOTIC AND/OR ANTIHYPERTENSIVE COMPOSITION Hypertension and thrombotic conditions in mammals are treated by administration of sulphite, bisulphite or cyclic sulphite ester of a monohydric or polyhydric alcohol.

METABOLITES OF ECTEINASCIDIN 743

The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as "ETM" followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are shown as ETM 305, ETM 204 and ETM 775.

QUATERNARY BIS-AMMONIUM SALT PRECURSORS AND THEIR USES AS PRODRUGS HAVING AN ANTIPARASITIC ACTIVITY

... ²²²L'invention concerne des précurseurs de drogues à effet antipaludique, ²caractérisés en ce qu'il s'agit de sels de bis-ammonium quaternaire de formule ²générale (I) dans laquelle A et A', identiques ou différents, sont soit, ²respectivement, un groupe A1 et A'1 de formule (1) où n = 2 à 4; R'1 est ²hydrogène, alkyle en C1 à C5, éventuellement substitué par un aryle, un ²hydroxy, un alkoxy, dans lequel l'alkyle comprend de 1 à 5 C, ou aryloxy et W ²est halogène ou un groupe nucléofuge, soit un groupe A2 qui représente un ²formyle -CHO, ou acétyl -COCH3. B et B', identiques ou différents, ²représentent: soit respectivement les groupes B1 et B'1, si A et A' ²représentent respectivement A1 et A'1 , B1 et B'1 représentant un groupe R1 ²qui présente la même définition que R'1 ci-dessus, mais ne peut pas être un ²atome d'hydrogène, soit respectivement les groupes B2 et B'2, si A et A' ²représentent A2, B2 ou B'2 étant le groupe R1 tel que défini ci-dessus, ou un ²groupement de formule (2) dans ...

POLYUNSATURATED FATTY ACID MONOGLYCERIDES, DERIVATIVES, AND USES THEREOF

The invention emcompasses polyunsaturated fatty acid monoglycerides and d erivatives thereof, having the formulae (I), (II), (III) and (IV), pharmaceu tically acceptable salts thereof, compositions thereof and processes of prep aring said compounds. These compounds can be useful as cancer chemopreventiv e agents, cancer treating agents, or radioenhencers for radiotherapy of canc er, or for inhibiting tumor growth or cell proliferation, or reducing tumor growth.

USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES

... 2087449 9203131 PCTABS00010 A class of heterocyclic amino-alcohol compounds is described for treatment of CNS-related diseases, namely, for use as a neuroprotective agent, to reduce neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, myocardial infarct, perinatal asphyxia, or hypoglycemic events. Other examples of treatable CNS-related diseases include neurodegenerative diseases such as Parkinson's disease, Huntington's chorea and Alzheimer's disease, and also psychotic disorders such as schizophrenia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as a mediator to alter excitatory actions at the NMDA excitatory amino acid receptor complex. A compound of this class of specific interest is formula (I).

COMPOUNDS HAVING BOTH POTENT CALCIUM ANTAGONIST AND ANTIOXIDANT ACTIVITY AND USE THEREOF AS CYTOPROTECTIVE AGENTS

Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.

IMMUNOSUPPRESSANT AND ANTIALLERGIC COMPOUNDS E.G. N-(3-OXOHEXANOYL) HOMOSERINE LACTONE

A compound having formula (1) for use as a medicament wherein n is 2 or 3; Y is O, S or NH; X is O, S or NH; and R is C1-C18 alkyl or acyl which may be substituted.