Phenoxybenzylamine derivatives as SSRIs.

Acompound of general formula (1)wherein r1 and r2 are h, c1-c6alkyl or(ch2)d(c3-c6cycloalkyl)wherein d=0,1,2 or 3; or r1 and r2 together with the nitrogen to which they are attached form an azetidine ring; z or y is -sr3 and the other z or y is halogen or -r3; wherein r3 is c1-c4 alkyl optionally substituted with fluorine; except that r3 is not cf3; or z and y are linked so that, together with the interconnecting atoms, z and y form fused 5 to 7-membered cabocyclic or heterocyclic ring, and wherein when z and y form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; r4 and r5, which may be the same or different, are: a-x, wherein a= -ch=ch- or -(ch2)p- where p is 0,1 or 2; x is hydrogen,f,cl,br,i,conr6r7,so2nr6r7, so2nhc(=o)r6,oh,c1-4alkoxy, nr8so2r9, no2, nr6r11, cn, co2r10, cho, sr10, s(0)r9, or a 5- or 6-membered heterocyclic ring containing 1,2,or 3 heteroatoms selected from n, s and o, optionally substituted independently by one or more r13, wherein r13 is hydroxy, c1-c4alkoxy, f,c11-c6alkyl, haloakyl, haloalkoxy, -nh2, -nh(c1-c6alkyl)or -n(c1-c6alkyl)2.