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Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 5566. Отображено 100.
27-02-2007 дата публикации

УСТАНОВКА ОЧИСТКИ УГЛЕВОДОРОДНОГО СЫРЬЯ ОТ СЕРООРГАНИЧЕСКИХ СОЕДИНЕНИЙ

Номер: RU0000061282U1
Автор: Белослудцев Александр Пименович, Иванов Сергей Иванович, Лободенков Александр Кузьмич, Мисилин Юрий Васильевич, Мокшаев Александр Николаевич, Молчанов Сергей Александрович, Никитин Владимир Иванович, Савин Юрий Михайлович, Сироткин Николай Степанович, Столыпин Василий Иванович, Трынов Анатолий Михайлович, Чехонин Михаил Федорович, Шушпанов Анатолий Трофимович
Принадлежит: Общество с ограниченной ответственностью "Оренбурггазпром" (ООО "Оренбурггазпром")

Установка очистки углеводородного сырья от сероорганических соединений, содержащая блок демеркаптанизации углеводородного сырья раствором щелочи с линиями подачи углеводородного сырья и выхода очищенных углеводородов и насыщенного меркаптидами щелочного раствора, блок адсорбционной осушки очищенных углеводородов с линией выхода осушенных углеводородов, блок регенерации насыщенного меркаптидами щелочного раствора с линиями выхода дисульфидов и регенерированной щелочи на блок демеркаптанизации углеводородного сырья, отличающаяся тем, что она дополнительно содержит блок фракционирования дисульфидов, установленный после блока регенерации насыщенного меркаптидами щелочного раствора, с линиями выхода диметилдисульфидов и кубового остатка, включающий адсорберы, соединенные через трубное пространство рекуперативного теплообменника с ректификационной колонной, верх которой через межтрубное пространство рекуперативного теплообменника, холодильник и рефлюксную емкость соединен с линией выхода диметилдисульфидов, причем последняя соединена линией орошения с верхом ректификационной колонны, низ которой соединен через второй холодильник и вторую рефлюксную емкость с линией выхода кубового остатка. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 61 282 (13) U1 (51) МПК C10G 27/06 (2006.01) C07C 319/14 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2006132630/22 , 11.09.2006 (24) Дата начала отсчета срока действия патента: 11.09.2006 (45) Опубликовано: 27.02.2007 U 1 6 1 2 8 2 R U Формула полезной модели Установка очистки углеводородного сырья от сероорганических соединений, содержащая блок демеркаптанизации углеводородного сырья раствором щелочи с линиями подачи углеводородного сырья и выхода очищенных углеводородов и насыщенного меркаптидами щелочного раствора, блок адсорбционной осушки очищенных углеводородов с линией выхода осушенных углеводородов, блок регенерации насыщенного меркаптидами ...

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Номер записи: 1
27-09-2007 дата публикации

УСТАНОВКА ПОЛУЧЕНИЯ ОДОРАНТА ИЗ УГЛЕВОДОРОДОВ

Номер: RU0000066743U1
Автор: Белослудцев Александр Пименович, Иванов Сергей Иванович, Михайленко Сергей Анатольевич, Молчанов Сергей Александрович, Морозов Михаил Михайлович, Никитин Владимир Иванович, Пантелеев Дмитрий Вячеславович, Плугатырь Валерий Иванович, Савин Юрий Михайлович, Столыпин Василий Иванович, Трынов Анатолий Михайлович, Чехонин Михаил Федорович
Принадлежит: Общество с ограниченной ответственностью "Оренбурггазпром" (ООО "Оренбурггазпром")

Установка получения одоранта из углеводородов, содержащая последовательно включенные в технологическую схему блок экстракции легкокипящих меркаптанов, включающий линию подачи углеводородов, колонны, емкость с раствором щелочи, смесители, холодильник, теплообменник, отстойную емкость, линии отвода очищенного стабильного конденсата и выхода насыщенного меркаптидами щелочного раствора, блок регенерации насыщенного меркаптидами щелочного раствора, включающий колонну, отстойник-коагулятор, сборник-накопитель легкокипящих меркаптанов, теплообменники, холодильники, линии отвода регенерированной щелочи в емкость с раствором щелочи на блок экстракции и выхода легкокипящих меркаптанов, блок адсорбционной осушки легкокипящих меркаптанов, включающий накопительные емкости, адсорберы, линии отвода воды и выхода осушенных легкокипящих меркаптанов, блок приема и хранения одоранта, включающий накопительные емкости и узел налива одоранта, а также соединительные трубопроводы и насосы, отличающаяся тем, что она дополнительно содержит установленный между блоками адсорбционной осушки легкокипящих меркаптанов и приема и хранения одоранта блок фракционирования легкокипящих меркаптанов с линиями отвода одоранта и кубового остатка, включающий две ректификационные колонны, низ которых через теплообменники и водяной холодильник соединен с линией отвода кубового остатка, верх первой ректификационной колонны через водяной холодильник, первую рефлюксную емкость и теплообменник соединен со второй ректификационной колонной, верх которой через водяной холодильник и вторую рефлюксную емкость соединен с линией отвода одоранта, причем рефлюксные емкости соединены также с верхом ректификационных колонн. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 66 743 (13) U1 (51) МПК C07C 319/02 C07C 319/28 (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2006130276/22 , 21.08.2006 (24) Дата начала отсчета срока ...

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Номер записи: 2
29-03-2012 дата публикации

Process for the preparation of cilastatin and sodium salt

Номер: US20120078009A1
Автор: Ganapathy Panchapakesan, Gollapalli Venkateswara Rao, NAGAPPAN Arumugam, Pandi Suresh Pandian, Subramaniam Ganesan
Принадлежит: ORCHID CHEMICALS AND PHARMACEUTICALS LTD

An improved process for preparing Cilastatin Sodium including dissolving Cilastatin acid in a solvent using an organic base, adding sodium salt of a week acid and isolating Cilastatin Sodium.

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Номер записи: 3
21-06-2012 дата публикации

Methods for Preparing Diaryl Disulfides

Номер: US20120157716A1
Автор: Rajendra P. Singh, Teruo Umemoto
Принадлежит: UBE Industries Ltd

New and useful methods for preparing bulky diaryl disulfides from a benzene derivative and sulfur halide are disclosed.

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Номер записи: 4
28-06-2012 дата публикации

Process for preparing methylmercaptopropionaldehyde

Номер: US20120165573A1
Автор: Benjamin FONFE, Caspar Heinrich FINKELDEI, Hans Joachim Hasselbach, Martin Koerfer, Pablo Zacchi, Stephan Kretz, Wolfgang Boeck
Принадлежит: EVONIK DEGUSSA GmbH

A process for preparing methylmercaptopropionaldehyde in a single reaction unit, is provided. According to the preferred embodiment, the process comprises, simultaneously contacting a gaseous mixture comprising acrolein with a liquid mixture comprising methylmercaptopropionaldehyde, methyl mercaptan, a catalyst and methylmercaptopropionaldehyde methyl thiohemiacetal in the reactive absorber; absorbing the acrolein from the gaseous mixture into the liquid mixture; reacting the absorbed acrolein with the methyl mercaptan or the methylmercaptopropionaldehyde methyl thiohemiacetal to obtain methylmercapto-propionaldehyde; removing gaseous impurities and by-products from the liquid mixture; and separating the obtained methylmercaptopropionaldehyde product from the reactive absorber, directing a portion of the separated product to storage or further processing and recycling the remaining portion to the reactive absorber; wherein the methyl mercaptan optionally comprises dimethyl sulfide or dimethyl ether.

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Номер записи: 5
27-09-2012 дата публикации

Method for producing n-acylamino acid

Номер: US20120245381A1
Автор: Toshiaki Suzuki
Принадлежит: Sumitomo Chemical Co Ltd

There is provided a method for producing N-acylamino acid of formula (I): wherein R 1 , R 2 and R 3 are the same or different and each independently represents a hydrogen atom, a substituted or unsubstituted hydrocarbyl group, or a substituted or unsubstituted heterocyclic group, which comprises supplying an aldehyde compound of formula (II): wherein R 1 is as defined above, an amide compound of formula (III): wherein R 2 and R 3 are as defined above, and a solvent to a reactor in which a solvent, a palladium compound, a halide compound, and carbon monoxide had been charged.

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Номер записи: 6
27-12-2012 дата публикации

Method for preparing acrolein from glycerol or glycerine

Номер: US20120330049A1
Автор: Benjamin Katryniok, Franck Dumeignil, Mickael Capron, Sebastien Paul
Принадлежит: Adisseo France SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Universite De Lille 1 Sciences Et Technologies

The invention relates to a method for preparing acrolein from glycerol or glycerin, according to which dehydration of glycerol or glycerin is carried out in the presence of a catalyst which consists in at least one silica modified with zirconium dioxide, titanium dioxide or tungsten trioxide or any combination of these oxides, and a heteropolyacid. This method may be used for making 3-(methylthio)propionic aldehyde (MMP), 2-hydroxy-4-methylthiobutyronitrile (HMBTN), methionine or its analogs, from acrolein.

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Номер записи: 7
21-03-2013 дата публикации

Method for producing methionine

Номер: US20130072713A1
Автор: Kazuyasu Tani, Koji Hagiya
Принадлежит: Sumitomo Chemical Co Ltd

A novel method for producing methionine without using hydrogen cyanide as a raw material has been demanded. A method for producing methionine including a step A of oxidizing 4-methylthio-2-oxo-1-butanal in the presence of an alcohol; a step B of hydrolyzing a 4-methylthio-2-oxo-butanoic acid ester obtained in the step A; and a step C of subjecting 4-methylthio-2-oxo-butanoic acid obtained in the step B to reductive amination.

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Номер записи: 8
28-03-2013 дата публикации

Thiol-Selective Water-Soluble Polymer Derivatives

Номер: US20130079555A1
Автор: Gross Remy F., Kozlowski Antoni, McManus Samuel P.
Принадлежит: Nektar Therapeutics

The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus. 1. A method for a preparing a conjugate , said method comprising:reacting a water-soluble polymer comprising a water-soluble polymer segment (“POLY”) having one terminus activated with an electrophile (“-E”) with a molecule of the structure “NU—Y—S, comprising a nucleophile (“—NU”) and a maleimide (“—S”), and a linear group (“—Y—”) interposed between NU and S, under conditions effective to promote reaction between said electrophile and said nucleophile to form a polymer product comprising a maleimide (“POLY-S”),wherein the molecular mass of the water-soluble polymer segment is from 1,000 Daltons to 50,000 Daltons; andreacting the polymer product comprising a maleimide with a biologically active agent comprising a thiol group, to thereby result in a conjugate.2. The method of claim 1 , wherein said water-soluble polymer segment is selected from the group consisting of poly(alkylene oxide) claim 1 , poly(vinyl pyrrolidone) claim 1 , poly(vinyl alcohol) claim 1 , polyoxazoline claim 1 , poly(acryloylmorpholine) claim 1 , and poly(oxyethylated polyol).3. The method of claim 1 , wherein the POLY-S product comprises greater than about 95% by weight mono-functionally substituted POLY-S.4. The method of claim 1 , wherein the POLY-S product comprises less than about 5% di-functionally-substituted POLY-S.5. The method of claim 2 , wherein the water-soluble polymer segment is a polyalkylene oxide.6. The method of claim 5 , wherein said-water soluble polymer segment is a polyethylene glycol (PEG).7. The method of claim 6 , wherein said polyethylene glycol is end-capped.8. The method of claim 1 , wherein said electrophile is a carboxylic acid or a carboxylic acid ...

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Номер записи: 9
16-05-2013 дата публикации

Method for Functionalizing Natural Fatty Substances

Номер: US20130123456A1
Автор: Boutevin Bernard, Caillol Sylvain, Desroches Myriam
Принадлежит:

The invention relates to a method for functionalizing natural fatty substances: According to said method, plant oils including at least two unsaturations and the derivatives thereof, fatty acids including at least one unsaturated compound and the derivatives thereof, and mixtures of same, are reacted with a thiol derivative of formula (I), at a temperature of between 0° C. and the temperature of total degradation of the natural fatty substance and in the presence of a thermal initiator compound or a redox initiator, or by UV radiation, or by UV radiation and in the presence of a photoinitiator. The invention also relates to the resulting functionalized fatty substances and to the use thereof for the preparation of polymers. The invention further relates to a method for preparing polymers from at least one functionalized fatty substance obtained by said functionalization method. 4. The method according to in which the vegetable oil and the derivatives thereof comprise between 2 and 20 unsaturations.5. The method according to in which the vegetable oil is chosen from among natural crude or purified vegetable oils claim 3 , and vegetable oils derived from genetically modified plants or cultures.6. The method according to in which the vegetable oil is chosen from among canola oil claim 5 , safflower oil claim 5 , rapeseed oil claim 5 , cottonseed oil claim 5 , linseed oil claim 5 , corn oil claim 5 , hazelnut oil claim 5 , coconut oil claim 5 , olive oil claim 5 , palm oil claim 5 , grape-seed oil claim 5 , castor oil claim 5 , sesame oil claim 5 , soybean oil claim 5 , sunflower oil claim 5 , alone or in a mixture.7. The method according to in which the derivatives of vegetable oils are fatty esters obtained by esterification or transesterification of the vegetable oils in claim 5 , fatty amides obtained by amidification or transamidification of the vegetable oils in claim 5 , partly epoxidated oils.8. The method according to in which the fatty acids and their ...

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Номер записи: 10
23-05-2013 дата публикации

PREPARATION OF CHALCONE DERIVATIVES

Номер: US20130131372A1
Автор: Bertrand Karine, Rool Patrice, Roudot Alice
Принадлежит: GENFIT

The invention relates to methods for producing chalcone (1,3-diphenylprop-2-en-1-one) derivatives that have multiple substitutions on a phenyl ring. Intermediate chalcone derivatives are modified by Phase Transfer Catalysis (PTC) for introducing a substituted alkyl group that is provided by a sulfonic acid derivative on a phenyl ring already containing substituent groups on one or two carbon atoms adjacent to the carbon atom where a substituent group is being introduced. The methods of the invention allow producing efficiently, by either S-alkylation or O-alkylation, chalcones derivatives that are characterized for their biological activities that are intermediate compounds for producing molecules having such activities, or that can be used for generating libraries of compounds to be screened by means of in vitro and/or in vivo assays and establishing structure-activity relationships. 115.-. (canceled)17. The method of claim 16 , wherein Rgroup is an unsubstituted alkyl or alkenyl group having from two to seven carbon atoms.18. The method of claim 16 , wherein L group is CO—CH═CH claim 16 , CO—CH—CH claim 16 , CH═CH—CO or CH—CH—CO.19. The method of claim 16 , wherein one of the substituent groups among X claim 16 , X claim 16 , X claim 16 , X claim 16 , and Xof General Formula (I) and (I) is a halogen claim 16 , a Ra or Ga—Ra group and the other four substituent groups among X claim 16 , X claim 16 , X claim 16 , X claim 16 , and Xgroups are hydrogen atoms.20. The method of claim 16 , wherein Xof General Formula (I) and (I) is a halogen claim 16 , a Ror G-Rgroup and the other four substituent groups among X claim 16 , X claim 16 , X claim 16 , and Xgroups are hydrogen atoms.21. The method of claim 16 , wherein the Xsubstituent group of General Formula (I) that claim 16 , after step (b) becomes a G-Rgroup claim 16 , is a G-H group.22. The method of claim 16 , wherein Gis an oxygen atom.23. The method of claim 16 , wherein the compounds of General Formula (I) and (I) ...

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Номер записи: 11
30-05-2013 дата публикации

PROCESS FOR PREPARING SULFUR-CONTAINING 2-KETOCARBOXYLATE COMPOUND

Номер: US20130137896A1
Автор: HAGIYA Koji, Hirose Taro, TANI Kazuyasu
Принадлежит: Sumitomo Chemical Company, Limited

The present invention provides a novel process for preparing a sulfur-containing 2-ketocarboxylate compound without using any enzyme. The process comprises a step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position in the presence of ruthenium metal or a ruthenium compound. Preferably, the step is carried out under pressurized condition, and more preferably, in the presence of at least one typical metal selected from the group consisting of an alkali metal compound and an alkaline earth metal compound. 1. A process for preparing a sulfur-containing 2-ketocarboxylate compound comprising a step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position in the presence of at least one catalyst selected from the group consisting of a ruthenium metal and a ruthenium compound.2. The process of wherein the step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position is carried out under pressurized condition.3. The process of or wherein the step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position is carried out in the presence of at least one typical metal compound selected from the group consisting of an alkali metal compound and an alkaline earth metal compound.4. The process of wherein the typical metal compound is an alkali metal hydroxide.5. The process of wherein the step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position is carried out in the presence of oxygen claim 1 ,7. The process of wherein Ris methyl group and n is 2. The present invention relates to a process for preparing a sulfur-containing 2-ketocarboxylate compound.It is known that sulfur-containing 2-ketocarboxylate compounds such as 4-methylthio-2-oxobutyric acid are, ...

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Номер записи: 12
30-05-2013 дата публикации

PROCESS FOR PREPARING SULFUR-CONTAINING 2-KETOCARBOXYLATE COMPOUND

Номер: US20130137897A1
Автор: HAGIYA Koji, Hirose Taro, TANI Kazuyasu
Принадлежит: Sumitomo Chemical Company, Limited

The present invention provides a novel process for preparing a sulfur-containing 2-ketocarboxylate compound without using any enzyme. The process comprises a step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position in the presence of a vanadium compound. Preferably, the step is carried out further in the presence of oxygen, and more preferably, in the presence of an organic solvent. 1. A process for preparing a sulfur-containing 2-ketocarboxylate compound comprising a step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position in the presence of a vanadium compound.2. The process of wherein the step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position is carried out in the presence of oxygen.3. The process of wherein the step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position is carried out in the presence of an organic solvent.4. The process of wherein the organic solvent is at least one solvent selected from the group consisting of a ketone solvent claim 3 , a nitrile solvent and an aromatic solvent.5. The process of wherein the vanadium compound is at least one compound selected from the group consisting of a trivalent vanadium compound claim 1 , a tetravalent vanadium compound and a pentavalent vanadium compound.7. The process of wherein Ris methyl group and n is 2. The present invention relates to a process for preparing a sulfur-containing 2-ketocarboxylate compound.It is known that sulfur-containing 2-ketocarboxylate compounds such as 4-methylthio-2-oxobutyric acid are, for example, useful intermediates for preparing medicaments and agrochemicals.A conventional process for preparing a sulfur-containing 2-ketocarboxylate compound is disclosed in, for example, Non-patent Document 1. In ...

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Номер записи: 13
06-06-2013 дата публикации

PROCESS FOR PRODUCING METHIONINE

Номер: US20130143279A1
Автор: Asako Hiroyuki, HAGIYA Koji
Принадлежит: Sumitomo Chemical Company, Limited

The present invention relates to a process for producing methionine, comprising a first step of reacting 2-amino-3-buten-1-ol with methanethiol, and a second step of oxidizing 2-amino-4-methylthio-1-butanol obtained in the first step. The present invention also relates to a process for producing 2-amino-4-methylthio-1-butanol, comprising a step of reacting 2-amino-3-buten-1-ol with methanethiol. 1. A process for producing methionine , comprising a first step of reacting 2-amino-3-buten-1-ol with methanethiol , and a second step of oxidizing 2-amino-4-methylthio-1-butanol obtained in the first step.2. The process according to claim 1 , wherein the first step is a step of reacting 2-amino-3-buten-1-ol with methanethiol in the presence of a radical initiator.3. The process according to claim 2 , wherein the radical initiator is an azo compound.4. The process according to claim 1 , wherein the first step is a step of reacting 2-amino-3-buten-1-ol with methanethiol in the presence of a solvent.5. The process according to claim 4 , wherein the solvent is an ester solvent.6. The process according to claim 1 , wherein the second step is a step of oxidizing 2-amino-4-methylthio-1-butanol in the presence of at least one metal selected from the group consisting of copper and the elements belonging to Group 8 claim 1 , 9 or 10 of the periodic table.7. The process according to claim 1 , wherein the second step is a step of oxidizing 2-amino-4-methylthio-1-butanol in the presence of copper and water.8. The process according to claim 1 , wherein the second step is a step of oxidizing 2-amino-4-methylthio-1-butanol in the presence of oxygen and either ruthenium or platinum.9. The process according to claim 6 , wherein the second step is a step of oxidizing 2-amino-4-methylthio-1-butanol further in the presence of at least one typical metal compound selected from the group consisting of alkali metal compounds and alkaline earth metal compounds.10. The process according to the claim ...

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Номер записи: 14
13-06-2013 дата публикации

Mercapto Benzophenone Compounds, Compositions and Preparation Method Thereof

Номер: US20130150479A1
Автор: HU Weijing, LI Jiaqi, LI Jing, MA Zhongli, WANG Yonglin, YAO Lixiu, Zhang Jue, ZHAO Wenchao
Принадлежит: Insight High Technology (Beijing) Co. Ltd.

The present invention provides a photocurable composition prepared using mercapto benzophenone compounds as key raw materials. The present invention aims to solve the problems existing in the prior photo-curing technology that low-molecular photoinitiators are easy to remain and migrate, while macromolecular photoinitiators has low initiation efficiency due to a low content of effective components and also has the problem of certain migration. The photocurable composition in the present invention can be easily prepared and has high addition efficiency with ethylenically unsaturated compounds, and the photocurable composition obtained by addition has no residual mercapto and has features of high initiation activity and zero migration rates when it is used in photocurable coatings, binder and ink formula. 3. The photocurable composition according to claim 2 , wherein: in the compound of said formula (I) claim 2 , R claim 2 , R claim 2 , R claim 2 , and Rare H claim 2 , and Ris methyl claim 2 , Cl claim 2 , or F; or R claim 2 , R claim 2 , R claim 2 , and Rare H claim 2 , and Ris methyl claim 2 , methoxy claim 2 , methylthio claim 2 , dimethylamino claim 2 , diethylamino claim 2 , F claim 2 , or phenyl; or R claim 2 , R claim 2 , and Rare H claim 2 , and Rand Rindependently of one another are Cl claim 2 , or methyl.43. The photocurable composition according to any one of - claims 1 , wherein component (a) is in an amount of 0.05-75% by weight relative to the total weight of said composition.53. The photocurable composition according to any one of - claims 1 , wherein component (b) includes acrylate compound claims 1 , allyl ether compound or mixture thereof.63. The photocurable composition according to any one of - claims 1 , wherein amine promotor compound can be added in said addition reaction.7. The photocurable composition according to claim 6 , wherein said amine promotor compound includes tertiary amine compound and/or active amine.8. The photocurable composition ...

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Номер записи: 15
20-06-2013 дата публикации

METHOD FOR PRODUCING METHIONINE

Номер: US20130158292A1
Автор: HAGIYA Koji, TANI Kazuyasu
Принадлежит: Sumitomo Chemical Company, Limited

A novel method capable of producing methionine without using hydrogen cyanide as a raw material has been desired. The present invention relates to a method for producing methionine including Step A of oxidizing 4-methylthio-2-oxo--butanal in the presence of an alcohol, and Step B of reductively aminating 4-methylthio-2-oxo-butyrate obtained in Step A. It is preferable that Step A is carried out by reacting 4-methylthio-2-oxo--butanal, the alcohol and an oxidizing agent in the presence of a carbene catalyst. 1. A method for producing methionine comprising:Step A of oxidizing 4-methylthio-2-oxo-1-butanal in the presence of an alcohol; andStep B of reductively aminating 4-methylthio-2-oxo-butyrate obtained in Step A.2. The production method according to claim 1 , wherein Step A is carried out by reacting 4-methylthio-2-oxo-1-butanal claim 1 , the alcohol and an oxidizing agent in the presence of a carbene catalyst.4. The production method according to claim 2 , wherein the oxidizing agent in Step A is oxygen and/or carbon dioxide.5. The production method according to claim 1 , wherein the alcohol is methanol or ethanol.6. The production method according to claim 1 , wherein Step B is carried out in the presence of a solvent.7. The production method according to claim 6 , wherein the solvent in Step B is methanol or water.8. The production method according to claim 1 , wherein Step B is carried out by reacting 4-methylthio-2-oxo-butyrate claim 1 , ammonia and a reducing agent in the presence of a transition metal.9. The production method according to claim 8 , wherein the transition metal in Step B is at least one metal selected from the group consisting of ruthenium claim 8 , rhodium claim 8 , palladium claim 8 , platinum claim 8 , iridium claim 8 , nickel claim 8 , cobalt and copper. 1. Field of the InventionThe present application is filed, claiming the Paris Convention priority based on Japanese Patent Application No. 2011-273052 (filed on Dec. 14, 2011), and the ...

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Номер записи: 16
27-06-2013 дата публикации

COMPOSITION BASED ON CERIUM, ZIRCONIUM AND TUNGSTEN, PREPARATION PROCESS AND USE IN CATALYSIS

Номер: US20130164201A1
Автор: Harris Deborah Jane, Hernandez Julien, Jones Clare, Jorge Coelho Marques Rui, Rohart Emmanuel
Принадлежит:

A composition based on cerium, zirconium and tungsten is described. The composition has a content expressed as an oxide, of which cerium is from 5% to 30% of the composition, tungsten is from 2% to 17% of the composition, and the remainder of the composition is zirconium. After aging at 750° C. under an air atmosphere including 10% water, it has a two-phase crystallographic structure having a tetragonal zirconia phase and a monoclinic zirconia phase, with no presence of a crystalline phase including tungsten. The composition can be used as a catalyst, especially in an SCR process. 1. A composition comprising cerium , zirconium and tungsten , wherein the composition has the following mass contents , expressed as oxide:cerium oxide: from 5% tobctwccn 5% and 30%;tungsten oxide: from 2% tobctwccn 2% and 17%;the remainder as zirconium oxide;and in that after aging at 750° C. in an air atmosphere comprising 10% water, it has a two-phase crystallographic structure comprising a tetragonal zirconia phase and a monoclinic zirconia phase, with no presence of a crystalline phase comprising tungsten.2. The composition as defined in claim 1 , wherein after aging claim 1 , the composition has a specific surface area of at least 30 m/g.3. The composition as defined in claim 1 , wherein after aging claim 1 , the composition has a specific surface area of at least 40 m/g.4. The composition as defined in claim 1 , wherein the composition has a two-phase crystallographic structure in which the tetragonal zirconia phase and the monoclinic zirconia phase are in a ratio of at least 5.5. The process as defined in claim 1 , wherein the process is comprised of the following steps:{'sub': 2', '3, '(a) preparing an aqueous solution comprising sulfate anions and a zirconium salt, which can optionally be zirconium oxychloride, in proportions such that the ratio ZrO/SOis from 1/0.40 to 1/0.52,'}(b) cooling the solution to a temperature below 25° C.,(c) adding an alkaline compound to precipitate ...

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Номер записи: 17
27-06-2013 дата публикации

Organosulfur Compounds for the Prevention and Treatment of Neurodegenerative Diseases

Номер: US20130165515A1
Автор: Ott David Michael
Принадлежит:

Divalent salts of S-allylmercapto-N-acetylcysteine and related compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia. 1. A method of treating a neurodegenerative disease or condition selected from the group of(a) the condition of amyloid-beta plaque formation that is associated with the development and progression of senile dementia or Alzheimer's disease,(b) the condition of Lewy body formation that is associated with the development and progression of Lewy body disease or Parkinson's disease,(c) the condition of carbonylation of proteins within the brain that is associated with the development and progression of Alzheimer's or Parkinson's Disease,(d) the condition of neurofibrillary tangle formation that is associated with tauopathies and Alzheimer's disease'(e) the condition of neuronal demylenation that is associated with the development and progression of peripheral neuropathy, spinal cord injury, or the disease of multiple sclerosis.(f) the condition of aldehyde mediated protein damage that is associated with the immediate recovery from stroke and cerebral ischemia and their subsequent progression,said method comprising:administering to an animal in need thereof an organosulfur composition comprising an effective amount of the mixed disulfide of a lipophilic mercaptan disulfide bonded to N-acetylcysteine further bonded as a two to one salt with a divalent cation;said lipophilic mercaptan being constrained to have a linear or branched carbon backbone, a single sulfur atom, and a molecular mass of 200 g/mol or less;wherein said lipophilic ...

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Номер записи: 18
04-07-2013 дата публикации

METHOD FOR PREPARING A COMPLEX OF AN ACID AND A METAL

Номер: US20130172617A1
Автор: Henryon Vivien, LE THIESSE Jean-Claude, REY Patrick
Принадлежит: ADISSEO IRELAND LIMITED

The invention concerns a method for preparing a complex of an acid chosen from among methionine, 2-hydroxy-4-methylthiobutanoic acid (HMTBA) and lactic acid, and of at least one metal, starting from said acid and a mineral metal source, wherein the acid is caused to react with the mineral metal source in an extruder. 1. A method for preparing a complex of an acid chosen from among methionine , 2-hydroxy-4-methylthiobutanoic acid (HMTBA) and lactic acid , and of at least one metal , starting from the said acid and a mineral metal source , characterized in that the acid is placed in reaction with the mineral metal source in an extruder.2. The method according to claim 1 , wherein the metal is chosen from among Li claim 1 , Na claim 1 , K claim 1 , Mg claim 1 , Ca claim 1 , Mn claim 1 , Fe claim 1 , Co claim 1 , Ni claim 1 , Cu claim 1 , Zn claim 1 , Pt.3. The method according to claim 1 , wherein the mineral metal source is chosen from among metallic hydroxides claim 1 , metallic hydroxide milks claim 1 , metallic oxides and corresponding metallic carbonates claim 1 , whether or not of natural origin.4. The method according to claim 3 , wherein the mineral metal source is of natural origin and is chosen from among shells claim 3 , ores and rocks.5. The method according to claim 1 , wherein the acid is 2-hydroxy-4-methylthiobutanoic acid (HMTBA) and the metal is calcium claim 1 , the calcium source being chosen from among lime claim 1 , milk of lime claim 1 , slaked lime claim 1 , calcium hydrogen carbonate and calcium carbonate.6. The method according to wherein the mineral metal source is chosen from among oyster shell claim 5 , snail shell claim 5 , dolomite.7. The method according to claim 3 , wherein the calcium source is Ca(OH).8. The method according to claim 1 , wherein the acid is methionine or 2-hydroxy-4-methylthiobutanoic acid (HMTBA) and a metal is chosen from among zinc claim 1 , manganese and copper claim 1 , the metal source being chosen from among the ...

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Номер записи: 19
18-07-2013 дата публикации

METHOD FOR PREPARING AN AMINO ACID FROM 2 AMINOBUTYROLACTONE

Номер: US20130184474A1
Автор: Henryon Vivien, Huet Robert, Joerger Jean-Michel
Принадлежит: ADISSEO FRANCE S.A.S.

The invention relates to a method for preparing an amino acid, or its salts, from 2-aminobutyrolactone (2ABL), said amino acid fitting the formula I, XCHCHCHNHCOOH, wherein X is such that X represents a nucleophilic ion, according to which N-carboxylation of 2-aminobutyrolactone (2ABL) is achieved with carbon dioxide, and the thereby obtained 2ABL carbamate is reactive with an XH reagent or its salts. 1. A method for preparing an amino acid , or its salts , from 2-aminobutyrolactone (2ABL) , said amino acid fitting the formula I , XCHCHCHNHCOOH , wherein X is such that X represents a nucleophilic ion , characterized in that it comprises the following steps:N-carboxylation of 2-aminobutyrolactone (2ABL) is achieved with carbon dioxide, andthe N-carboxyl of the thereby obtained 2ABL is reacted with a reagent XH or its salts and acidification is performed.2. The method according to claim 1 , characterized in that X is selected from CHS claim 1 , CHSe claim 1 , SH claim 1 , SeH claim 1 , CN.3. The method according to claim 1 , characterized in that an amino acid selected from methionine and selenomethionine.4. The method according to claim 1 , characterized in that homocysteine and its dimer are obtained.5. The method according to claim 1 , characterized in that N-carboxylation is carried out in an aprotic polar solvent.6. The method according to claim 5 , characterized in that the solvent is selected from dimethylsulfoxide and N-methylpyrrolidone.7. The method according to claim 1 , characterized in that the L isomer of the amino acid claim 1 , the D isomer or mixtures of the latter and notably the racemic mixture are prepared from the corresponding form of 2ABL.8. The method according to claim 1 , characterized in that 2ABL is obtained from homoserine.9. The method according to claim 8 , characterized in that homoserine is the L isomer and is obtained by microbiological fermentation of sugars of natural origin.10. The method according to claim 1 , characterized in ...

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Номер записи: 20
25-07-2013 дата публикации

CATALYST FOR REMOVING NITROGEN OXIDES FROM THE EXHAUST GAS OF DIESEL ENGINES

Номер: US20130189172A1
Автор: Malmberg Stephan, Mueller Elena, Soeger Nicola, Spurk Paul
Принадлежит: UMICORE AG & CO. KG

The invention relates to a catalyst for removal of nitrogen oxides from the exhaust gas of diesel engines, and to a process for reducing the level of nitrogen oxides in the exhaust gas of diesel engines. The catalyst consists of a support body of length L and of a catalytically active coating which in turn may be formed from one or more material zones. The material zones comprise selectively catalytically reductive (SCR-active) mixed oxide consisting of cerium oxide, zirconium oxide, rare earth sesquioxide and niobium oxide and optionally tungsten oxide. In addition, the material zones comprise at least one compound selected from the group consisting of barium oxide, barium hydroxide, barium carbonate, strontium oxide, strontium hydroxide, strontium carbonate, praseodymium oxide, lanthanum oxide, magnesium oxide, mixed magnesium/aluminum oxide, alkali metal oxide, alkali metal hydroxide, alkali metal carbonate and mixtures thereof. Noble metal may optionally also be present in the catalyst. 1. A catalyst for removing nitrogen oxides from the exhaust gas of diesel engines , consisting of a support body of length L and a catalytically active coating composed of one or more material zones comprisinga) a catalytically active mixed oxide consisting of cerium oxide, zirconium oxide, rare earth sesquioxide and niobium oxide and optionally tungsten oxide; andb) at least one compound selected from the group consisting of barium oxide, barium hydroxide, barium carbonate, strontium oxide, strontium hydroxide, strontium carbonate, praseodymium oxide, lanthanum oxide, magnesium oxide, mixed magnesium/aluminum oxide, alkali metal oxide, alkali metal hydroxide, alkali metal carbonate and mixtures thereof.2. The catalyst as claimed in claim 1 , wherein the catalytically active mixed oxide claim 1 , based on the total amount thereof claim 1 , has the following composition:{'sub': '2', 'CeO: 15-50% by wt.'}{'sub': 2', '5, 'NbO: 3-25% by wt.'}{'sub': 2', '3, 'REO: 3-10% by wt.'}{'sub ...

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Номер записи: 21
01-08-2013 дата публикации

NEW PROCESS

Номер: US20130197257A1
Автор: Harnett Gerard John, Hayes John, Reents Reinhard, Smith Dennis A., Walsh Andrew
Принадлежит: Hoffmann-La Roche Inc.

A process for the preparation of a compound of formula (I): 2. A process according to claim 1 , wherein the coupling reaction is carried out in the presence of a secondary amine.3. A process according to claim 2 , wherein Ris pent-3-yl.9. A process according to claim 1 , wherein the coupling reaction is followed by a mineral acid quenching with hydrofluoric acid claim 1 , hydrochloric acid claim 1 , boric acid claim 1 , acetic acid claim 1 , formic acid claim 1 , nitric acid claim 1 , phosphoric acid or sulfuric acid.10. A process according to claim 1 , wherein the coupling reaction is followed by a hydrochloric acid quenching.11. A process according to claim 1 , wherein a nonprotic solvent is present.12. A process according to claim 11 , wherein the nonprotic solvent is tetrahydrofuran.13. A process according to claim 11 , wherein the alkylating agent is 1-halo-CHRor a sulfonate ester of RCH—OH wherein Ris defined in .14. A process according to claim 1 , wherein the alkylating agent is 1-halo-2-ethylbutane.15. A process according to claim 1 , wherein the alkylating agent is 2-ethyl-1-butanol.16. A process according to claim 1 , wherein the alkylating agent is 1-bromo-2-ethylbutane.17. A process according to claim 1 , wherein the Grignard reagent is a (C-C)alkyl-magnesium-halide claim 1 , phenyl-magnesium-halide claim 1 , heteroaryl-magnesium-halide or a (C-C)cycloakyl-magnesium-halide.18. A process according to claim 1 , wherein the Grignard reagent is methylmagnesiumchloride.19. A process according to claim 2 , wherein the secondary amine is diethylamine or diisopropylamine.20. A process according to claim 2 , wherein the secondary amine is diethylamine.21. A process according to claim 2 , wherein the secondary amine is in a catalytic amount.22. A process according to claim 2 , wherein 0.01 to 0.5 equivalents of the secondary amine is used.23. A process according to claim 2 , wherein the process is continuous.24. A process according to claim 8 , wherein the ...

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Номер записи: 22
22-08-2013 дата публикации

PROCESS FOR OBTAINING ACROLEIN BY CATALYTIC DEHYDRATION OF GLYCEROL OR GLYCERIN

Номер: US20130217909A1
Автор: Belliere-Baca Virginie, Fatah Nouria, Pariente Stephane, Paul Sebastien
Принадлежит:

A continuous process for obtaining acrolein by catalytic dehydration of glycerol or glycerin, in the presence of an acid catalyst, wherein said process comprises the concomitant regeneration of said catalyst and is carried out in a fluidized bed reactor, said reactor comprising two zones, a first zone, or lower zone, termed catalyst regeneration zone, in which a fluidization gas comprising oxygen is introduced, and a second zone, or upper zone, termed reaction zone, in which the glycerol or glycerin is introduced and converted into acrolein. 1. A continuous process for the production of acrolein by catalytic dehydration of glycerol or glycerin in the presence of an acid catalyst , characterized in that it comprises the concomitant regeneration of said catalyst and in that it is carried out in a fluidized bed reactor , said reactor comprising two regions , a first region , or lower region , referred to as region for regeneration of the catalyst , into which an oxygen-comprising fluidizing gas is introduced , and a second region , or upper region , referred to as reaction region , into which the glycerol or the glycerin is introduced and converted into acrolein.2. The process as claimed in claim 1 , characterized in that the glycerol or the glycerin is introduced in the form of an aqueous solution in a concentration varying from 10% to 90% by weight.3. The process as claimed in claim 2 , characterized in that the glycerol or glycerin solution is introduced in the vaporized form.4. The process as claimed in claim 1 , characterized in the acid catalyst is chosen from zeolites claim 1 , phosphates claim 1 , heteropolyacids claim 1 , which are optionally supported and/or doped claim 1 , catalysts of oxide or supported oxide types claim 1 , or also of the type formed of zirconias claim 1 , which are modified and/or doped.5. The process as claimed in claim 4 , characterized in that the catalyst is chosen from supported or unsupported heteropolyacids doped with at least one ...

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Номер записи: 23
22-08-2013 дата публикации

PROCESS FOR PREPARING MERCAPTOALKYL CARBOXYLATES

Номер: US20130217912A1
Автор: Baldamus Jens, Garlichs Florian, Kaibel Gerd
Принадлежит: BASF SE

In the acid-catalyzed esterification of mercaptoalkyl alcohols by means of carboxylic acids to form mercaptoalkly carboxylates, formation of undesirable, usually sparingly soluble by-products usually occurs. The process of the invention in the absence of acid catalysts avoids the formation of such by-products. Particularly when the esterification of the invention is carried out as reactive distillation using reactive column and residence vessel, good degrees of conversion can also be obtained without acid catalyst and at the same time the formation of the by-products can be largely avoided. 1. A process for preparing mercaptoalkyl carboxylates by esterification from the starting materials carboxylic acid and mercaptoalkyl alcohol in the absence of an additional active acid catalyst , where said additional active acid catalyst is an amount of an acid which brings about an increase in the rate of said esterification by at least 200% averaged over the total esterification mixture , under otherwise identical esterification conditions , compared to the esterification of the carboxylic acid by means of the mercaptoalkyl alcohol without additional acid , and where the esterification is carried out as reactive distillation , whereina) the starting materials carboxylic acid and mercaptoalkyl alcohol are fed as a continuous stream into the reaction zone of a rectification column,b) the starting materials react in the rectification column to form the reaction products mercaptoalkyl carboxylate and water of reaction,c) the reaction mixture is fractionally distilled in the rectification column andd) a mercaptoalkyl carboxylate-comprising fraction is discharged at the top and a fraction comprising water of reaction is discharged at the top of the rectification column.2. A process for preparing mercaptoalkyl carboxylates by esterification from the starting materials carboxylic acid and mercaptoalkyl alcohol in the absence of an additional active acid catalyst , where said ...

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Номер записи: 24
29-08-2013 дата публикации

OXIDE CATALYST, PROCESS FOR PRODUCING OXIDE CATALYST, PROCESS FOR PRODUCING UNSATURATED ACID, AND PROCESS FOR PRODUCING UNSATURATED NITRILE

Номер: US20130225862A1
Автор: Ichihara Takeo, Kato Takaaki, TATENO Eri
Принадлежит: ASAHI KASEI CHEMICALS CORPORATION

Disclosed is a process for producing an oxide catalyst for use in the gas-phase catalytic oxidation reaction or the like of propane or the like, the process comprising the steps of: (I) obtaining a preparation containing compounds of Mo, V, Nb, and Sb or Te at the predetermined atomic ratios; (II) drying the preparation to obtain a dry powder; and (III) calcining the dry powder, wherein the step (III) comprises the step of calcining the dry powder in the presence of a compound containing W in the form of a solid to obtain a pre-stage calcined powder or a mainly calcined powder, or the step of calcining the dry powder and calcining the obtained pre-stage calcined powder in the presence of the solid to obtain a mainly calcined powder, the solid satisfies the predetermined conditions, and the oxide catalyst comprises a catalytic component having the predetermined composition. 1. A particulate oxide catalyst for use in the gas-phase catalytic oxidation reaction or the gas-phase catalytic ammoxidation reaction of propane or isobutane ,the oxide catalyst containing a Mo compound, a V compound, a Nb compound, a compound of at least one element selected from the group consisting of Sb and Te, a W compound, and an optional compound of at least one element selected from the group consisting of Mn, B, Ti, Al, Ta, an alkali metal, an alkaline earth metal, La, Ce, Pr, Yb, Co, Y, and Sc, at atomic ratios represented by the following formula (0), wherein {'br': None, 'sub': Mo', 'V', 'W', 'Nb', 'X', 'Z, 'C:C:C:C:C:C=1:a:w:c:x:z \u2003\u2003(0)'}, 'W is concentrated within the surface of the particle of the oxide catalyst and in proximity thereto{'sub': Mo', 'V', 'W', 'Nb', 'X', 'Z, 'wherein Crepresents the atomic ratio of Mo; Crepresents the atomic ratio of V; Crepresents the atomic ratio of W; Crepresents the atomic ratio of Nb; Crepresents the atomic ratio of at least one element selected from the group consisting of Sb and Te; Crepresents the atomic ratio of at least one ...

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Номер записи: 25
05-09-2013 дата публикации

METHOD FOR THE PREPARATION OF (3S, 3S') 4,4'-DISULFANEDIYLBIS (3-AMINOBUTANE 1-SULFONIC ACID)

Номер: US20130231500A1
Автор: Balavoine Fabrice, Cartigny Yohann, Coquerel Gerard, Couvrat Nicolas, Madec Jonathan, Petit Marie-Noelle, Schneider Jean-Marie
Принадлежит: QUANTUM GEOMICS

The present invention relates to a new method for the preparation of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A. 118.-. (canceled)19. A process for preparing (3S ,3S′) 4 ,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) from (S) ethyl 2-(benzyloxycarbonylamino) 4-(neopentyloxysulfonyl)butanoate A comprising the steps of:(a) reducing the ethyl ester of A to give (S) neopentyl 3-(benzyloxycarbonylamino) 4-hydroxybutane 1-sulfonate B;(b) reacting the alcohol B with methanesulfonic anhydride or methanesulfonyl chloride in presence of a base to give (S) neopentyl 3-(benzyloxycarbonylamino) 4-(methylsulfonyloxy)butane 1-sulfonate C;(c) reacting the mesylated alcohol C with potassium thioacetate to give (S) 2-(benzyloxycarbonylamino) 4-(neopentyloxysulfonyl)butyl thioacetate D;(d) dimerizing D to give (3S,3S′) neopentyl 4,4′-disulfanediylbis(3-(benzyloxycarbonylamino)butane 1-sulfonate) E; and(e) deprotecting sulfonic ester and amine groups of E to give (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid).20. The process according to claim 19 , wherein step (a) is performed by reacting A with a reducing agent—solvent couple selected from NaBH/LiCl—mixture of THF and ethanol and LiBH—THF claim 19 , at a temperature from about 0° C. to about 25° C.21. The process according to claim 19 , wherein step (a) is performed by reacting A with LiBH—THF claim 19 , at a temperature from about 20° C. to about 25° C.22. The process according to claim 19 , wherein step (b) is performed in presence of triethylamine as base claim 19 , in a solvent selected from chloroform and a mixture of MTBE and toluene claim 19 , at a temperature from about −10° C. to about 10° C.23. The process according to claim 19 , wherein step (b) is performed by reacting B with methanesulfonyl chloride claim 19 , in presence of triethylamine as base claim 19 , in a mixture of MTBE and toluene in ...

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Номер записи: 26
05-09-2013 дата публикации

METHOD OF PRODUCTION OF A METHIONINE SALT

Номер: US20130231501A1
Автор: Gangadwala Jignesh, Gruener Christof P., Hanrath Franz H., Hasselbach Hans Joachim, Koerfer Martin, Krull Horst, Stock Juergen
Принадлежит: EVONIK DEGUSSA GmbH

A reaction system suitable for production of a methionine salt contains a reactive rectification column containing a weir having a height of 100 mm or more. 1. A reaction system , comprising: 'a weir having a height of 100 mm or more;', 'a reactive rectification column comprising'}wherein said reaction system is suitable for production of a methionine salt.2. The reaction system according to claim 1 , wherein said reactive rectification column further comprises:a plate;whereinthe weir height is in the range from 100 to 1000 mma plate spacing is in the range from 500 to 1000 mm,the ratio of column diameter to weir length is in the range from 1.1 to 1.3,a ratio of a cross-sectional area of the column to an area through which a gas flows is in the range from 1.5 to 2, andthe number of plates is in the range from 15 to 25.3. The reaction system according to claim 1 , wherein said reactive rectification column is a sieve plate column claim 1 , perforated plate column claim 1 , valve plate column or bubble plate column.4. The reaction system according to claim 1 , wherein said reactive rectification column further comprises: at least one plate;wherein the ratio of a total area of all holes of said at least one plate/area through which a gas flows is in the range from 0.04 to 0.08, anda diameter of the individual holes in the plate is in the range from 5 to 10 mm.5. The reaction system according to claim 1 , wherein the weir height of said reactive rectification column is such that an average residence time of a reaction mixture is less than 0.5 min per plate.6. The reaction system according to claim 1 , further comprising:at least one reactive absorber; andoptionally, a second reactor for the production of 5-(2-methylmercaptoethyl)-hydantoin.7. The reaction system according to claim 6 , wherein the reactive absorber is a jet washer system.8. The reaction system according to claim 6 , wherein zirconium is used in the reactive-rectification column and/or in the reactive ...

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Номер записи: 27
05-09-2013 дата публикации

Microorganism producing L-methionine precursor and method of producing L-methionine and organic acid from the L-methionine precursor

Номер: US20130231503A1
Автор: Chang Jin-Sook, Cho Young-wook, Choi Kwang-myung, Choi Kyung-oh, KIM So-young, PARK YOUNG-HOON, Shin Yong-Uk, Um Hye-won
Принадлежит: CJ CHEILJEDANG CORPORATION

The present invention relates to a method for producing L-methionine, comprising: i) culturing an L-methionine precursor-producing microorganism strain in a fermentation solution, so that the L-methionine precursor accumulates in the solution; and ii) mixing a converting enzyme and methylmercaptan or its salts with at least a portion of the solution to convert the accumulated L-methionine precursor into L-methionine, as well as to microorganism strains used in each step. 1. A method for producing L-methionine , comprising:i) culturing an L-methionine precursor-producing microorganism strain in a fermentation solution, so that the L-methionine precursor accumulates in the solution; andii) mixing a converting enzyme and methylmercaptan or its salts with at least a portion of the solution to convert the accumulated L-methionine precursor into L-methionine.2. The method of claim 1 , wherein said the L-methionine precursor is an O-acylhomoserine.3EscherichiaErwiniaSerratiaProvidenciaCorynebacteriumPseudomonasLeptospiraSalmonellarBrevibacteriumHyphomonasChromobacteriumNocardia. The method of claim 1 , wherein the L-methionine precursor-producing microorganism strain of step i) is selected from the group consisting of sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. and sp. or fungi or yeasts.4EscherichiaCorynebacterium. The method of claim 3 , wherein the L-methionine precursor-producing microorganism strain is selected from sp. and sp.5Escherichia coli.. The method of claim 4 , wherein the L-methionine precursor-producing microorganism strain is6Corynebacterium glutamicum.. The method of claim 4 , wherein the L-methionine precursor-producing microorganism strain is7. The method of claim 1 , wherein the L-methionine precursor-producing microorganism strain is prepared by deleting or weakening the activity of cystathionine gamma synthase or O-succinylhomoserine sulfhydrylase or O ...

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Номер записи: 28
19-09-2013 дата публикации

METHOD FOR THE CONVERSION OF METHYLMERCAPTOPROPIONALDEHYDE FORMED FROM CRUDE ACROLEIN AND CRUDE METHYL MERCAPTAN

Номер: US20130245318A1
Автор: Gangadwala Jignesh, Hasselbach Hans Joachim, Jakob Harald, Koerfer Martin, Steffan Martin
Принадлежит: EVONIK DEGUSSA GmbH

A reactive rectification column suitable for the production of 2-hydroxy-4-methylmercaptobutyric acid and/or methionine contains a weir having a height of 100 mm or more. 1. A reactive rectification column , comprising:a weir having a height of 100 mm or more;wherein said reactive rectification column is suitable for production of a methionine salt.2. The reactive rectification column according to claim 1 , further comprising: wherein', 'the weir height is in the range from 100 to 1000 mm', 'a plate spacing is in the range from 500 to 1000 mm,', 'the ratio of column diameter to weir length is in the range from 1.1 to 1.3,', 'a ratio of a cross-sectional area of the column to an area through which a gas flows is in the range from 1.5 to 2, and', 'the number of plates is in the range from 15 to 25., 'a plate;'}3. The reactive rectification column according to claim 1 , which is a sieve plate column claim 1 , perforated plate column claim 1 , valve plate column or bubble plate column.4. The reactive rectification column according to claim 1 , further comprising: wherein the ratio of a total area of all holes of said at least one plate/area through which a gas flows is in the range from 0.04 to 0.08, and', 'a diameter of the individual holes in the plate is in the range from 5 to 10 mm., 'at least one plate;'}5. The reactive rectification column according to claim 1 , wherein the weir height is such that an average residence time of a reaction mixture is less than 0.5 min per plate.6. The reactive rectification column according to claim 1 , wherein zirconium is used as material for a part in contact with the product.7. The reactive rectification column according to claim 1 , further comprising: wherein', 'the weir height for the upper plate is in the range from 100 to 200 mm at a plate spacing in the range from 800 to 1000 mm,', 'the weir height for the middle plate is in the range from 400 to 600 mm at a plate spacing in the range from 700 to 900 mm, and', 'the weir ...

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Номер записи: 29
10-10-2013 дата публикации

PROCESS FOR PREPARING DIALKYL DISULPHIDES

Номер: US20130267739A1
Автор: Fremy Georges, Raymond Jean-Michel
Принадлежит: Arkema France

The present disclosure relates to a process for obtaining dialkyl disulphides from alkyl mercaptan and from sulphur, in which a reaction intermediate present in the final disulphide is decomposed at the end of synthesis. This operation makes it possible to avoid the degradation of said reaction intermediate over time, which is responsible for the decrease in purity of the dialkyl disulphide. 111-. (canceled)12. A process for treating a reaction crude containing a majority of a dialkyl disulphide obtained by oxidation of at least one alkyl mercaptan with sulphur , comprising , contacting said reaction crude with at least one basic catalyst.13. The process according to claim 12 , wherein the at least one alkyl mercaptan is a compound of formula RSH claim 12 , and the dialkyl disulphide is a compound of formula RSSR claim 12 , wherein R represents a linear or branched alkyl radical containing from 1 to 20 carbon atoms claim 12 , optionally substituted with one or more groups claim 12 , which may be identical or different claim 12 , chosen from halogens claim 12 , amino claim 12 , alkylamino claim 12 , dialkylamino claim 12 , carboxyl claim 12 , alkylcarbonyloxy claim 12 , alkoxycarbonyl claim 12 , hydroxyalkyl claim 12 , alkoxy claim 12 , mercaptoalkyl claim 12 , alkylthio claim 12 , alkylcarbonylamino and alkylaminocarbonyl.14. The process according to claim 13 , wherein R represents a linear or branched alkyl radical containing from 1 to 10 carbon atoms claim 13 , optionally substituted with one or more groups claim 13 , which may be identical or different claim 13 , chosen from halogens claim 13 , amino claim 13 , alkylamino claim 13 , dialkylamino claim 13 , carboxyl claim 13 , alkylcarbonyloxy claim 13 , alkoxycarbonyl claim 13 , hydroxyalkyl claim 13 , alkoxy claim 13 , mercaptoalkyl claim 13 , alkylthio claim 13 , alkylcarbonylamino and alkylaminocarbonyl15. The process according to claim 12 , wherein the at least one alkyl mercaptan is a compound of formula RSH ...

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Номер записи: 30
05-12-2013 дата публикации

PROCESS FOR MANUFACTURING ACROLEIN/ACRYLIC ACID

Номер: US20130324758A1
Автор: Devaux Jean-Francois, Dubois Jean-Luc
Принадлежит: Arkema France

The present invention relates to the selective elimination of propanal in acrolein-rich streams to produce acrolein and/or acrylic acid and/or acrylonitrile and/or methylmercaptopropionaldehyde containing low amount of propanal and/or propionic acid and/or propionitrile. One subject of the present invention is a process for manufacturing acrolein comprising a step of selective elimination of propanal in an acrolein-rich stream in contact with a catalyst comprising at least molybdenum. Another subject of the present invention is a process for manufacturing acrylic acid from glycerol including a step of selective elimination of propanal in an acrolein-rich stream in contact with a catalyst comprising at least molybdenum. 1. Process for manufacturing acrolein characterized in that it comprises selective elimination of propanal in an acrolein-rich stream by passing the said stream in gas phase in the presence of oxygen through a catalyst comprising at least molybdenum and at least one element selected from P , Si , W , Ti , Zr , V , Nb , Ta , Cr , Mn , Fe , Co , Ni , Cu , Zn , Ga , In , Tl , Sn , Ag , As , Ge , B , Bi , La , Ba Sb Te , Ce , Pb.2. Process according to characterized in that the catalyst is chosen from the group consisting of the mixed metal oxides containing at least molybdenum and heteropolyacids containing at least molybdenum.3. Process according to characterized in that the catalyst is one mixed metal oxide containing at least molybdenum.4. Process according to characterized in that the catalyst contains iron molybdate mixed oxide.5. Process according to characterized in that the catalyst is one heteropolyacid containing at least molybdenum.6. Process according to characterized in that the catalyst comprises at least one heteropolyacid containing at least molybdenum in which proton in the heteropolyacid may be partially exchanged by at least one cation selected from elements belonging to Group 1 to 16 of the Periodic Table of elements.8. Process ...

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Номер записи: 31
12-12-2013 дата публикации

Novel Heterocyclic Compound, Method For Producing Intermediate Therefor, And Use Thereof

Номер: US20130330876A1
Автор: Eisei KANOH, Hirokazu Kuwabara, Kazuki NIIMI, Kazuo Takimiya, Yuichi Sadamitsu
Принадлежит: Nippon Kayaku Co Ltd

Provided are a novel heterocyclic compound represented by formula (1), and a field-effect transistor having a semiconductor layer comprising the aforementioned compound. Also provided is a method for producing an intermediate enabling the production of the aforementioned novel heterocyclic compound. (In the formula, R 1 and R 2 represent a hydrogen atom, a C 2-16 alkyl group or an aryl group. However, when R 1 each independently represents a C 2-16 alkyl group or an aryl group, R 2 represents a hydrogen atom or each independently represents an aryl group; and when R 1 represents a hydrogen atom, R 2 each independently represents an aryl group.)

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Номер записи: 32
12-12-2013 дата публикации

SILICA-STABILIZED ULTRAFINE ANATASE TITANIA, VANADIA CATALYSTS, AND METHODS OF PRODUCTION THEREOF

Номер: US20130331259A1
Автор: Chapman David M.
Принадлежит: Cristal USA Inc.

The invention is directed to compositions and processes for the production of silica-stabilized ultrafine anatase titanias and which may further comprise tungsten and vanadia. The surface stabilization may be by treatment of the TiOparticles with a low molecular weight and/or small nanoparticle form of silica such as, in preferred embodiments, a tetra(alkyl)ammonium silicate or silicic acid, which serves to efficiently maintain the anatase phase and prevent crystal growth under severe thermal and hydrothermal conditions, even in the presence of vanadia. The vanadia catalysts produced from the novel titanias have equal or improved catalytic activity for selective catalytic reduction of NOx compared to conventional vanadia supported silica-titania based catalysts. The invention is further directed to diesel emission catalytic devices comprising the novel titania-based catalyst compositions. 1. A method of producing a catalyst support material , comprising:{'sub': '2', 'providing a slurry comprising TiO;'}{'sub': 2', '2', '2', '3', '2', '3', '2', '2', '3', '2, 'combining the TiOslurry with (1) a silica precursor solution comprising SiOsubstantially in a low molecular weight and/or SiOcomprising small nanoparticles and with (2) WOto form a TiO—WO—SiOmixture; wherein the silica precursor solution is combined with the TiOslurry before, after, or while the WOis combined with the TiOslurry; and'}{'sub': 2', '3', '2, 'washing and sintering the TiO—WO—SiOmixture to form a silica-stabilized titania support material.'}2. The method of wherein the silica-stabilized titania support material claim 1 , comprises:{'sub': 2', '2', '3, 'sup': '2', '86%-94% dry weight of TiO, 3%-9% dry weight of a SiO, and 3%-7% dry weight of WO; and wherein the titania support material primarily comprises a surface area of at least 80 m/gm before sintering.'}3. The method of wherein the TiOof the slurry comprise preformed titanium hydroxide claim 1 , titanium oxy-hydroxide or titanium dioxide ...

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Номер записи: 33
19-12-2013 дата публикации

ULTRASOUND ASSISTED IN-SITU FORMATION OF CARBON/SULFUR CATHODES

Номер: US20130337347A1
Автор: Amine Khalil, Pol Vilas G., Weng Wei
Принадлежит: UCHICAGO ARGONNE, LLC

A process of preparing an E-carbon nanocomposite includes contacting a porous carbon substrate with an E-containing material to form a mixture; and sonicating the mixture to form the E-carbon nanocomposite; where E is S, Se, SeS, or Te, x is greater than 0; and y is greater than 0. 1. A process of preparing an E-carbon nanocomposite , the process comprising:contacting a porous carbon substrate with an E-containing material to form a mixture; andsonicating the mixture to form the E-carbon nanocomposite; [{'sub': x', 'y, 'E is S, Se, SeS, or Te;'}, 'x is greater than 0; and', 'y is greater than 0., 'wherein2. The process of claim 1 , wherein the E-containing material is a salt.3. The process of claim 2 , wherein the salt and the porous carbon substrate are contacted in an aqueous medium.4. The process of claim 1 , wherein the aqueous medium further comprises an acid.5. The process of claim 1 , wherein E-containing material comprises SeS claim 1 , NaSO claim 1 , LiSO claim 1 , KSO claim 1 , (NH)SO claim 1 , or a hydrated form of NaSO claim 1 , LiSO claim 1 , KSO claim 1 , or (NH)SO claim 1 , where x and y are greater than 0.6. The process of claim 1 , wherein the S claim 1 , Se claim 1 , SeS claim 1 , or Te in the E-carbon nanocomposite is present from about 30 wt % to about 60 wt %.7. The process of claim 1 , wherein the porous carbon substrate comprises microporous carbon claim 1 , mesoporous carbon claim 1 , mesoporous microbeads claim 1 , graphite claim 1 , expandable graphite claim 1 , graphene claim 1 , carbon black claim 1 , or carbon nanotubes.8. A process of preparing a LiS-carbon nanocomposite claim 1 , the process comprising:contacting a porous carbon substrate with a material containing lithium and sulfur in a solid state to form a mixture;heating the mixture to form a heated mixture; and{'sub': '2', 'sonicating the heated mixture to form the LiS-carbon nanocomposite.'}9. The process of claim 8 , wherein the contacting and sonicating are performed under an ...

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Номер записи: 34
26-12-2013 дата публикации

METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND

Номер: US20130345434A1
Автор: Kanda Hisaaki, Konishi Hirotsugu, YAMAGUCHI Hiroki
Принадлежит: Sumitomo Seika Chemicals Co., Ltd.

The present invention provides a method for producing a 1,2-benzisothiazol-3-one compound by reacting a 2-(alkylthio)benzonitrile compound with a halogenating agent in the presence of water, wherein an alkyl halide that is generated as by-product is reacted with a sulfide to form an alkylthiol, which is converted into an alkali metal salt, and then the resulting alkali metal salt is reacted with a 2-halobenzonitrile compound to be converted into a 2-(alkylthio)benzonitrile compound and reused as a starting material for the production of a 1,2-benzisothiazol-3-one compound. By means of the present invention, it is possible to efficiently use the by-product that is generated during the production of a 1,2-benzisothiazol-3-one compound and economically produce a 1,2-benzisothiazol-3-one compound without placing a burden on the environment. 2. The method according to claim 1 , wherein the reaction of step (i) is conducted in the presence of water and a phase transfer catalyst.3. The method according to claim 1 , wherein the reaction of step (ii) is conducted in the presence of water and a phase transfer catalyst.4. The method according to claim 1 , wherein the sulfide used in step (i) is an alkali metal hydrogensulfide.5. The method according to claim 1 , wherein Ris a hydrogen atom and Ris a methyl group in formula (1).7. The method according to claim 2 , wherein the reaction of step (ii) is conducted in the presence of water and a phase transfer catalyst.8. The method according to claim 2 , wherein the sulfide used in step (i) is an alkali metal hydrogensulfide.9. The method according to claim 3 , wherein the sulfide used in step (i) is an alkali metal hydrogensulfide.10. The method according to claim 7 , wherein the sulfide used in step (i) is an alkali metal hydrogensulfide.11. The method according to claim 2 , wherein Ris a hydrogen atom and Ris a methyl group in formula (1).12. The method according to claim 3 , wherein Ris a hydrogen atom and Ris a methyl group in ...

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Номер записи: 35
02-01-2014 дата публикации

INTEGRATED PROCESS FOR PREPARING ACROLEIN AND 3-METHYLMERCAPTOPROPIONALDEHYDE

Номер: US20140005437A1
Автор: FINKELDEI Caspar Heinrich, Koerfer Martin, Zacchi Pablo
Принадлежит: Evonik Industries AG

A process to produce 3-methylmercaptopropionaldehyde is provided. The process comprises: A) oxidizing a mixture of propylene and inert diluent gases with air over a heterogeneous catalyst to obtain a gaseous oxidation reaction mixture comprising acrolein and by-products; B) quenching the gaseous oxidation reaction mixture to obtain a gas stream comprising acrolein and a quench liquid comprising residual acrolein and the by-products; C) stripping the acrolein from the by-products of the quench liquid and returning the stripped acrolein to the quench; D) absorbing a first portion of the gas stream comprising acrolein from the quench B) in water to obtain an aqueous acrolein solution and an uncondensable gaseous stream comprising inert gases; D1) recycling at least a portion of the uncondensable gaseous stream to the oxidation A) to supply the inert diluent gases; E) distilling the acrolein from the aqueous acrolein solution to obtain an acrolein-free aqueous bottom product; E1) condensing the distilled acrolein; F) reacting the distilled acrolein E1) and the gas stream comprising acrolein B) with methyl mercaptan in a mixture comprising at least one of 3-methylmercaptopropionaldehyde and a hemithioacetal of methyl mercaptan and 3-methylmercaptopropionaldehyde to obtain the 3-methylmercaptopropionaldehyde. 1. A process to produce 3-methylmercaptopropionaldehyde , comprising:A) oxidizing a mixture of propylene and inert diluent gases with air over a heterogeneous catalyst to obtain a gaseous oxidation reaction mixture comprising acrolein and by-products;B) quenching the gaseous oxidation reaction mixture to obtain a gas stream comprising acrolein and a quench liquid comprising residual acrolein and the by-products;C) recovering the acrolein by stripping from the quench liquid in a lower portion of the quench B) and returning the stripped acrolein to the quench B);D) absorbing a first portion of the gas stream comprising acrolein from the quench B) in water to obtain an ...

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Номер записи: 36
16-01-2014 дата публикации

PREPARATION METHOD OF DENITRATION CATALYST

Номер: US20140018236A1
Автор: Hikazudani Susumu, Hino Naoe
Принадлежит: HITACHI ZOSEN CORPORATION

Provided is a preparation method of a denitration catalyst for treating nitrogen oxides contained in exhaust gas discharged from gas turbines for generating plants, coil fired boilers, etc., in which the catalytic activity can be improved, and furthermore, an increase of the cost of producing the catalyst is not involved. The preparation method of a denitration catalyst used when reacting nitrogen oxides with reducing agent ammonia to decompose the nitrogen oxides into nitrogen and water, and including titanium oxide and vanadium as catalytic active ingredients thereof, is characterized in that the vanadium precursor is ammonium metavanadate powder, the ammonium metavanadate powder containing particles having a particle diameter of 10 μm or less in a cumulative ratio of 20% or more. The ammonium metavanadate powder is preferably a reclaimed product including vanadium recovered from petroleum-based combustion ash such as heavy oil ash. 1. A method for preparing a denitration catalyst which is used when reacting nitrogen oxides with ammonia as a reducing agent to decompose the nitrogen oxides into nitrogen and water and which includes titanium oxide , vanadium and tungsten as catalytic active ingredients thereof , characterized in that a precursor of the vanadium is ammonium metavanadate powder , the ammonium metavanadate powder containing particles having a particle diameter of 10 μm or less in a cumulative content of 20% or more.2. The method for preparing a denitration catalyst according to claim 1 , characterized in that the ammonium metavanadate powder is a reclaimed product including vanadium recovered from petroleum-based combustion ash claim 1 , such as heavy oil ash. The present invention relates to a preparation method of a denitration catalyst for treating nitrogen oxides contained in exhaust gas discharged from, for example, a gas turbines for generating plants, coal fired boilers, etc.Denitration catalysts used for treating nitrogen oxides contained in ...

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Номер записи: 37
30-01-2014 дата публикации

METHOD FOR PURIFYING L-CYSTEINE

Номер: US20140031586A1
Автор: Boehm Andreas, Leute Maria
Принадлежит: Wacker Chemie AG

The invention relates to a method for producing a purified solution containing L-cysteine from a fermentation broth containing L-cysteine. In said method, the fermentation broth containing L-cysteine, at a pH value from pH 6 to 9, is brought in contact with a basic anion exchanger, wherein the L-cysteine bonds to the anion exchanger. The anion exchanger is then rinsed with a first washing solution, and the bonded L-cysteine is removed from the anion exchanger by means of an acid and transferred into an eluate. Said eluate, having a pH≦4, is brought in contact with an acidic cation exchanger, wherein the L-cysteine bonds to the cation exchanger. The cation exchanger is rinsed with a second washing solution, and the bonded L-cysteine is removed from the cation exchanger by means of a strong acid. 1. A process for purifying L-cysteine from an L-cysteine-containing fermentation broth , comprising:bringing the L-cysteine-containing fermentation broth into contact at a pH of from 6 to 9 with a basic anion exchanger, such that L-cysteine in the broth binds to the anion exchanger to provide bound L-cysteine,flushing the anion exchanger with a first washing solution,contacting the anion exchanger with an acid to remove the bound L-cysteine from the anion exchanger and to form an eluate containing the L-cysteine,contacting the eluate at a pH of ≦4 with an acidic cation exchanger, such that the L-cysteine binds to the cation exchanger,flushing the cation exchanger with a second washing solution, andcontacting the cation exchanger strong acid to remove the L-cysteine from the cation exchanger and to provide a purified L-cysteine-containing solution.2. The process as claimed in claim 1 , wherein the cation exchanger is strongly acidic and the is strongly basic.3. The process as claimed in claim 1 , wherein the anion exchanger is used in a OH form and the cation exchanger is used in H form.4. The process as claimed in claim 1 , wherein the first washing solution is water having a ...

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Номер записи: 38
06-02-2014 дата публикации

System For Purifying, Producing And Storing Biomolecules

Номер: US20140037961A1
Автор: Evans David
Принадлежит: ADC BIOTECHNOLOGY LIMITED

The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): Ris an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NRor —S, wherein the free valence of —O, —NRor —S is bonded to the support optionally via a linker; and Ris hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group. 2. The method of claim 1 , wherein the method further comprises the step of washing the support-biomolecule compound.3. The method of or claim 1 , wherein the method further comprises the step of releasing the biomolecule from the support-biomolecule compound and recovering the biomolecule; and optionally recovering the support.4. The method of or claim 1 , wherein the method further comprises the steps of carrying out one or more chemical reactions on the support-biomolecule compound to synthesise support-biomolecule-drug compound;optionally washing the support-biomolecule-drug compound; andreleasing a biomolecule-drug conjugate from the support-biomolecule-drug compound,optionally, the method further comprises the step of recovering the support.5. The method of or claim 1 , wherein the method further comprises the step of drying the support-biomolecule compound;optionally, the method further comprises the step of releasing the biomolecule from the support-biomolecule compound and recovering the biomolecule.6. The method of any preceding claim ...

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Номер записи: 39
13-02-2014 дата публикации

DUAL-ACTING ANTIHYPERTENSIVE AGENTS

Номер: US20140046075A1
Автор: Choi Seok-ki, Fatheree Paul R., Hudson Ryan, Jendza Keith, McKinnell Robert Murray, Sasikumar Vivek
Принадлежит: THERAVANCE, INC.

The invention is directed to compounds of formula I: 131-. (canceled)3354-. (canceled) This application claims the benefit of U.S. Provisional Application No. 60/899,264, filed on Feb. 2, 2007 and No. 60/901,531, filed on Feb. 15, 2007; the entire disclosures of which are incorporated herein by reference in their entirety.1. Field of the InventionThe present invention relates to novel compounds having angiotensin type 1 (AT) receptor antagonist activity and neprilysin-inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat diseases such as hypertension.2. State of the ArtThe aim of antihypertensive therapy is to lower blood pressure and prevent hypertension-related complications such as myocardial infarction, stroke, and renal disease. For patients with uncomplicated hypertension (for example, no risk factors, target organ damage, or cardiovascular disease), it is hoped that reducing blood pressure will prevent development of cardiovascular and renal comorbidities, conditions that exist at the same time as the primary condition in the same patient. For those patients with existing risk factors or comorbidities, the therapeutic target is the slowing of comorbid disease progression and reduced mortality.Physicians generally prescribe pharmacological therapies for patients whose blood pressure cannot be adequately controlled by dietary and/or lifestyle modifications. Commonly used therapeutic classes act to promote diuresis, adrenergic inhibition, or vasodilation. A combination of drugs is often prescribed, depending upon what comorbidities are present.There are five common drug classes used to treat hypertension: diuretics, which include thiazide and thiazide-like diuretics such as hydrochlorothiazide, loop diuretics such as furosemide, and potassium-sparing diuretics such as triamterene; βadrenergic receptor blockers ...

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Номер записи: 40
13-02-2014 дата публикации

PROCESS FOR THE PREPARATION OF A POLYSULFIDE

Номер: US20140046097A1
Автор: He Jing, Klobes Olaf
Принадлежит:

Process for the preparation of polysulfide of formula (I) HS—(CH)—O—(CH)—O—(CH)—[S—S—CH)O—(CH)—O—(CH2)]-SH (I) wherein m is an integer in the range 1 to 4, n and p are integers in the range 1-10, and q is an integer in the range 1-60, by oxidizing a bismercaptodiether compound of formula (II) HS—(CH)—O—(CH)—O—(CH)—SH (II) with elemental sulfur in the presence of a base and a protic solvent. This process has a high selectivity towards linear disulfides. 1. Process for the preparation of polysulfide of formula (I){'br': None, 'HS—(CH2)n-O—(CH2)m-O—(CH2)p-[S—S—CH2)n-O—(CH2)m-O—(CH2)p]q-SH \u2003\u2003(I)'}wherein m is an integer in the range 1 to 4, n and p are integers in the range 1-10, and q is an integer in the range 1-60, {'br': None, 'HS—(CH2)n-O—(CH2)m-O—(CH2)p-SH \u2003\u2003(II)'}, 'by oxidizing a bismercaptodiether compound of formula (II)'}with elemental sulfur in the presence of a base and a protic solvent.2. Process according to wherein m=13. Process according to wherein n=p=24. Process according to any one of the preceding claims wherein the protic solvent is an alcohol.5. Process according to wherein the alcohol is methanol claim 4 , ethanol or isopropanol.6. Process according to wherein the base is a quaternary ammonium compound claim 1 , a tertiary amine claim 1 , or an inorganic base.7. Process according to wherein the base is triethylamine or NaOH.8. Process according to wherein the molar ratio elemental sulfur:bismercaptoether is in the range 0.5:1 to 1.2:1.9. Process according to wherein the molar ratio elemental sulfur:bismercaptoether is in the range 0.7:1 to 0.99:1.10. Process according to wherein the process is performed at a temperature in the range 60-85° C. The present invention relates to a process for the preparation of a polysulfide.Polysulfides are a class of polymers with alternating chains of several sulfur atoms and hydrocarbons. The general formula for the repeating unit is —[R—S]—, where x indicates the number of sulfur atoms, n ...

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Номер записи: 41
20-02-2014 дата публикации

SYNTHESIS OF MOLECULAR SIEVES FOR MODIFYING THE SURFACES OF NANOPARTICLES HAVING AMPHOTERIC IONS, AND APPLICATION THEREOF

Номер: US20140051883A1
Автор: JIN Ho, Kim Sungjee, Nam Jutaek, Park Joonhyuck
Принадлежит:

The present invention relates to a surface modification method for improving the dispersion of nanoparticles, and to nanoparticles having improved dispersion properties prepared by the method. More particularly, the present invention relates to a method in which amphoteric compounds are bonded to the surfaces of nanoparticles to improve dispersion at the surfaces of nanoparticles. The present invention also relates to nanoparticles using the method. Both anions and cations are formed on the surfaces of the nanoparticles according to the present invention, and therefore the nanoparticles are electrically stable so as to achieve stability in a wide pH range, are stably dispersed in the event of a high concentration of salts, and the non-specific adsorption thereof is reduced. Novel specific substances or sensors having minimized non-specific adsorption may be produced using the nanoparticles of the present invention. 134-. (canceled)36. The nanoparticle of claim 35 , wherein the nanoparticle is surface-substituted with the amphoteric ion molecule.37. The nanoparticle of claim 35 , wherein the nanoparticle is made of a metal claim 35 , a nonmetal claim 35 , ceramic claim 35 , plastic claim 35 , a polymer claim 35 , a semiconductor claim 35 , a quantum dot or at least one composite material thereof.38. The nanoparticle of claim 35 , wherein the nanoparticle is a nanoparticle having optical properties.39. The nanoparticle of claim 35 , wherein the nanoparticle is a fill-type nanoparticle whose inside is filled claim 35 , or a cavity-type nanoparticle whose inside is at least partially provided with a space.40. The nanoparticle of claim 35 , wherein a length of the amphoteric ion molecule is smaller than an outer diameter of the nanoparticle.42. The method of claim 41 , wherein claim 41 , before the reaction with the amphoteric ion molecule claim 41 , the nanoparticle is provided on a surface thereof with a ligand that can be substituted with the amphoteric ion molecule ...

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Номер записи: 42
20-02-2014 дата публикации

PROCESS FOR PREPARING METHYLMERCAPTOPROPIONALDEHYDE

Номер: US20140051890A1
Автор: Boeck Wolfgang, FINKELDEI Caspar Heinrich, Fonfe Benjamin, Hasselbach Hans Joachim, Koerfer Martin, Kretz Stephan, Zacchi Pablo
Принадлежит: EVONIK DEGUSSA GmbH

A process for preparing methylmercaptopropionaldehyde in a single reaction unit, is provided. According to the preferred embodiment, the process comprises, simultaneously contacting a gaseous mixture comprising acrolein with a liquid mixture comprising methylmercaptopropionaldehyde, methyl mercaptan, a catalyst and methylmercaptopropionaldehyde methyl thiohemiacetal in the reactive absorber; absorbing the acrolein from the gaseous mixture into the liquid mixture; reacting the absorbed acrolein with the methyl mercaptan or the methylmercaptopropionaldehyde methyl thiohemiacetal to obtain methylmercapto-propionaldehyde; removing gaseous impurities and by-products from the liquid mixture; and separating the obtained methylmercaptopropionaldehyde product from the reactive absorber, directing a portion of the separated product to storage or further processing and recycling the remaining portion to the reactive absorber; wherein the methyl mercaptan optionally comprises dimethyl sulfide or dimethyl ether. 1. A process for preparing methylmercaptopropionaldehyde in a single reaction unit , comprising , simultaneously:contacting a gaseous mixture comprising acrolein with a liquid mixture comprising methylmercaptopropionaldehyde, methyl mercaptan, a catalyst and methylmercaptopropionaldehyde methyl thiohemiacetal in the reaction unit;absorbing the acrolein from the gaseous mixture into the liquid mixture;reacting the absorbed acrolein with the methyl mercaptan or the methylmercaptopropionaldehyde methyl thiohemiacetal to obtain methylmercapto-propionaldehyde;removing gaseous impurities and by-products from the liquid mixture; andseparating the obtained methylmercaptopropionaldehyde product from the reaction unit, directing a portion of the separated product to storage or further processing and recycling the remaining portion to the reaction unit;wherein the methyl mercaptan is in the form of crude methyl mercaptan comprising greater than 87% by weight methyl mercaptan, 1.5 ...

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Номер записи: 43
20-02-2014 дата публикации

Process to purify dialkyl sulfides

Номер: US20140051891A1
Автор: Elizabeth Burkhardt, Kevin Neigh
Принадлежит: BASF SE

The invention relates to new processes to prepare low odor dialkyl sulfides, the low odor dialkyl sulfides obtainable by these processes and to methods of using these low odor dialkyl sulfides. Moreover, the invention relates to a process to prepare dialkyl sulfide borane complexes of high purity, the dialkyl sulfide borane complexes obtainable by this process and to a process for enantioselective reductions employing these dialkyl sulfide borane complexes of high purity as reducing agent.

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Номер записи: 44
06-03-2014 дата публикации

Method For The Preparation of Poly(Disulfide) Polymers and Gels

Номер: US20140066589A1
Автор: Puskas Judit E., Rosenthall Emily Q.
Принадлежит: THE UNIVERSITY OF AKRON

High molecular weight disulfide polymers are synthesized in aqueous media by exposing dithiol compounds to a mild oxidizing environment in the presence of a tertiary amine catalyst. The unique oxidizing system polymerizes monomers through the formation of sulfur-sulfur bonds between dithiol compounds. The same oxidizing system may be used to make disulfide-crosslinked gels from compounds containing multiple thiol groups. The oxidizing system is comprised of oxygen at atmospheric concentration and dilute hydrogen peroxide. A filler such as carbon black may be incorporated into the polymer or cross-linked gel during polymerization. A polydisulfide polymer is provided having a weight average molecular weight of greater than about 100,000 g/mol and a polydispersity index of about 2 or less. A tetrathiol composition results from a reaction of a diacrylate with a trithiol. The tetrathiol composition may be subjected to an oxidizing environment with a tertiary amine catalyst to provide a polytetrathiol polymer network. 1. A method for the synthesis of poly(disulfide) polymers , the method comprising:providing a dithiol composition, andsubjecting the dithiol composition to an oxidizing environment, in an aqueous solution and in the presence of a tertiary amine catalyst and an additional thiol-containing compound, to provide a crosslinked poly(disulfide) polymer network.2. The method of claim 1 , wherein the dithiol composition comprises at least one dithiol compound selected from the group consisting of aliphatic dithiols and alkoxy dithiols.3. The method of claim 2 , wherein the dithiol composition is a C-Ccompound.4. The method of claim 2 , wherein the dithiol composition is selected from the group consisting of ethanedithiol claim 2 , 2 claim 2 ,2′-[ethane-1 claim 2 ,2diylbis(oxy)]diethanethiol claim 2 , α claim 2 ,ω-thiol functionalized tetraethylene glycol claim 2 , α claim 2 ,ω-thiol functionalized poly(isobutylene) claim 2 , α claim 2 ,ω-thiol functionalized poly( ...

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Номер записи: 45
03-01-2019 дата публикации

Methods and systems for mask alignment in manufacturing process of arrays

Номер: US20190002410A1
Автор: David Smith, Gaurav Saini, Robert Kuimelis, Tommy ARMSBY
Принадлежит: HealthTell Inc

Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits containing molecules or salts thereof, and methods of determining alignment of photolithographic masks comprising molecules or salts thereof.

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Номер записи: 46
01-01-2015 дата публикации

SYSTEMS AND METHODS FOR PRODUCING DIMETHYL SULFIDE FROM GASIFIED COKE

Номер: US20150005207A1
Автор: FREEMAN John Justin, MILAM Stanley Nemec, TAYLOR Richard B., TEGELAAR Erik Willem
Принадлежит:

Petroleum coke or coal coke is gasified to produce a gas stream containing carbon monoxide, hydrogen, hydrogen sulfide, and optionally ammonia, carbon dioxide, water, and nitrogen. Carbon monoxide, hydrogen, and hydrogen sulfide, and optionally ammonia, carbon dioxide, water, and nitrogen are separated from the gas stream. The separated carbon monoxide and hydrogen are reacted to produce methanol, and the methanol is reacted with the separated hydrogen sulfide to produce dimethyl sulfide. 1. A method comprising:providing a gasified coke stream comprising carbon monoxide, hydrogen, hydrogen sulfide, carbon dioxide, and nitrogen;separating the gasified coke stream into a stream enriched in carbon monoxide relative to the gasified coke stream, a stream enriched in hydrogen relative to the gasified coke stream, and a stream enriched in hydrogen sulfide relative to the gasified coke stream;producing methanol from at least a portion of the separated carbon monoxide enriched stream and at least a portion of the separated hydrogen enriched stream; andproducing dimethyl sulfide from at least a portion of the produced methanol and at least a portion of the separated hydrogen sulfide enriched stream.2. The method of further comprising:gasifying coke to produce the gasified coke.3. The method of claim 2 , wherein the coke is a petroleum coke.4. The method of claim 3 , wherein the petroleum coke comprises at least 3 wt. % sulfur.5. The method of claim 2 , wherein the coke is a coal coke.6. The method of claim 5 , wherein the coal coke comprises at least 1 wt. % sulfur.7. The method of claim 1 , further comprising separating from the gasified coke stream a stream enriched in carbon dioxide relative to the gasified coke stream claim 1 , and compressing the carbon dioxide enriched stream.8. The method of further comprising:producing gasoline from at least a portion of the methanol.9. The method of further comprising:producing an olefin from at least a portion of the methanol.10. ...

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Номер записи: 47
11-01-2018 дата публикации

Process for the preparation of a polyunsaturated ketone compound

Номер: US20180009745A1
Автор: Inger-Reidun AUKRUST, Marcel Sanderberg
Принадлежит: Avexxin AS

A process for the preparation of a polyunsaturated thiol comprising: (1) reacting a polyunsaturated alcohol in the presence of a compound of formula R 2 —SO 2 Hal wherein R 2 is a C 1-20 hydrocarbyl group, such an C 1-10 alkyl group, to form a polyunsaturated sulphonyl ester; (2) converting the polyunsaturated sulphonyl ester to a polyunsaturated thioester by reacting with an anion of formula − SC(═O)R 4 wherein R 4 is a C 1-20 hydrocarbyl group; (3) converting the polyunsaturated thioester to form a polyunsaturated thiol optionally in the presence of an antioxidant, e.g. using a metal carbonate. (4) reacting said polyunsaturated thiol with a compound (LG)R 3 COX wherein X is an electron withdrawing group and R 3 is an alkylene group carrying a leaving group (LG), such as LG-CH 2 — forming where X is an electron withdrawing group and LG is a leaving group; optionally in the presence of an antioxidant, so as to form a polyunsaturated ketone compound.

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Номер записи: 48
14-01-2021 дата публикации

PREPARATION METHOD FOR 4-PHENYLTHIO-BENZENETHIOL

Номер: US20210009514A1
Автор: Chen Zhirong, LI Haoran, LI QICHUAN, LI WOYUAN, LIAN MING, PAN Shuaifeng, QIN Guangde, YIN Hong, Zhou Guiyang
Принадлежит:

The present disclosure discloses a preparation method for 4-phenylthio-benzenethiol. The preparation method comprises the following steps: subjecting phenyl sulfide as a raw material to a halogenation reaction to obtain 4-halophenyl sulfide; subjecting the 4-halophenyl sulfide to a sulfhydrylation reaction to obtain a 4-phenylthio-phenylthiolate; and subjecting the 4-phenylthio-phenylthiolate to acidification. The preparation method of the present disclosure avoids the use of materials such as thiophenol which pollutes the environment, and realizes efficient recycling of the reaction materials, solvents, water and the like. The preparation method of the present disclosure is a green process for the synthesis of 4-phenylthio-phenylthiol without organic waste, waste acid and waste water discharge. 1. A preparation method for 4-phenylthio-benzenethiol , comprising the steps of:subjecting phenyl sulfide as a raw material to a halogenation reaction to obtain 4-halophenyl sulfide;subjecting the 4-halophenyl sulfide to a sulfhydrylation reaction to obtain 4-phenylthio-phenylthiolate; andsubjecting the 4-phenylthio-phenylthiolate to acidification.2. The preparation method according to claim 1 , wherein claim 1 ,the halogenation reaction is: adding peroxide to a mixed solution containing phenyl sulfide, an organic solvent, a halogenating agent, and an inorganic acid to undergo a halogenation reaction, and obtaining 4-halophenyl sulfide by separation;the sulfhydrylation reaction is: subjecting the resulting 4-halophenyl sulfide and a SMAB-NaHS complex to a sulfhydrylation reaction, and obtaining an aqueous layer containing 4-phenylthio-phenylthiolate by extraction and separation; andthe acidification reaction is: subjecting the aqueous layer containing 4-phenylthio-phenylthiolate to an acidification reaction in an acidic aqueous solution, and obtaining the 4-phenylthio-benzenethiol by separation.3. The preparation method according to claim 2 , wherein claim 2 , in the ...

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Номер записи: 49
08-01-2015 дата публикации

PREPARATION OF-SULFENYLATED CARBONYL COMPOUNDS FROM PROPARGYLIC ALCOHOLS IN ONE STEP

Номер: US20150011796A1
Автор: Biswas Srijit, SAMEC Joseph
Принадлежит:

The present relates to a method and a kit to produce an optically pure α-sulfenylated carbonyl compound comprising a primary or a secondary propargylic alcohol and an aryl thiol, a transition metal catalyst and a solvent. 1. A method of preparing an α-sulfenylated carbonyl compound according to the present invention comprising:providing reactants comprising a primary or a secondary propargylic alcohol, a thiol and a transition metal catalyst;providing a solvent;mixing the reactants and the solvent;letting the reactants react.2. The method according to wherein the method is performed in one step with no intermediate steps.3. The method according to conducted in an inert atmosphere or in an open atmosphere.4. The method according to wherein the thiol is an aryl or alkyl thiol.5. The method according to wherein the catalyst is a catalyst comprising gold(III) claim 1 , gold(I) claim 1 , copper(I) claim 1 , palladium(II) or platinum(II) or mixtures thereof such as gold and palladium claim 1 , or copper and palladium claim 1 , or platinum and palladium.6. The method according to wherein the yield of the compound is 55 to 100% claim 1 , preferably 80 to 100%.7. The method according to wherein the catalyst is a gold(I) chloride or copper(I) iodide catalyst.8. The method according to wherein the method is performed in one step with no intermediate steps and wherein the thiol is a benzene thiol and the catalyst is a gold(I) chloride catalyst.9. The method according to wherein the transition metal catalyst is a mixture of gold(I) and palladium(II) and the thiol is an alkylthiol.10. A kit for preparing an α-sulfenylated carbonyl compound comprising a primary or a secondary propargylic alcohol and a thiol claim 1 , at least one transition metal catalyst and a solvent. The present invention relates to an atom efficient methodology to prepare α-sulfenylated carbonyl compounds from propargylic alcohols and thiols by means of transition metal catalysisAlfa sulfenylated carbonyl ...

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Номер записи: 50
09-01-2020 дата публикации

METHOD FOR PREPARING POLYTHIOLS

Номер: US20200010412A1
Автор: Corbel Louis, Fremy Georges, Monguillon Bernard, Saint-Louis-Augustin Pascal
Принадлежит: Arkema France

Provided is a process for preparing polythiols by preparing a sulfhydration reaction medium, simultaneously carrying out radical sulfhydration reaction of at least one polyene and acid-catalyzed sulfhydration reaction of the polyene and recovering a mixture including at least two polythiols. Also provided is a mixture of polythiols obtained from the process described herein. 1. A process for preparing polythiols comprising: at least one polyene;', 'at least one radical initiator;', 'at least one acid catalyst;', 'at least one sulfhydryl group donor compound;', 'optionally, at least one solvent;, 'a/ preparing a sulfhydration reaction medium comprising bringing into contactb/ simultaneously carrying out the radical sulfhydration reaction of said at least one polyene and the acid-catalyzed sulfhydration reaction of said at least one polyene; andc/ recovering a mixture comprising at least two polythiols.2. The process according to claim 1 , wherein said at least one polyene is a compound with a hydrocarbon chain that comprises at least two unsaturations in double bond form claim 1 , it being possible for said chain to be linear or cyclic claim 1 , saturated or unsaturated claim 1 , and to optionally comprise one or more heteroatoms chosen from columns 15 claim 1 , 16 and 17 of the Periodic Table of the Elements claim 1 , and to be interrupted or substituted by one or more aromatic groups.3. The process according to claim 1 , wherein said at least one polyene is a hydrocarbon compound comprising from 2 to 20 double bonds claim 1 , limits included.4. The process according to claim 1 , wherein said at least one polyene is chosen from triallylisocyanurate and derivatives thereof claim 1 , terpenes and derivatives thereof claim 1 , comprising at least two double bonds.5. The process according to claim 1 , wherein said at least one radical initiator is chosen from a thermal or photochemical initiator and a radical-generating organic or mineral compound claim 1 , taken alone ...

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Номер записи: 51
19-01-2017 дата публикации

METHOD FOR CRYSTALLIZATION OF 2-AMINO-2-[2-[4-(3-BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL]-ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE

Номер: US20170015624A1
Автор: KOMATSU Hidetaka, SATOH Hiroya
Принадлежит: Kyorin Pharmaceutical Co., Ltd.

A method for highly efficiently preparing high purity crystals of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chloro-phenyl]-ethyl]-1,3-propanediol hydrochloride. The method involves dissolving 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol in a mixed solvent comprising a solvent in which its hydrochloride is highly soluble and a solvent in which its hydrochloride is less soluble, to prepare a solution of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol; and then adding hydrochloric acid to the resulting solution with stirring, to crystallize the hydrochloride of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chloro-phenyl]ethyl]-1,3-propanediol. 1. A method for crystallizing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1 ,3-propanediol hydrochloride , comprising:dissolving 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1,3-propanediol in ethanol with heating;adding ethyl acetate to the ethanol containing the 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1,3-propanediol, resulting in a first solution;adding 1 to 12 mole/L of hydrochloric acid to the first solution at a temperature in a range 10 of 50° C. to 90° C. while stirring, resulting a second solution; andforming crystalline particles of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1,3-propanediol hydrochloride from the second solution at a temperature in a range of from 0° C. to 30° C. while stirring,wherein an amount of a mixed solvent comprising the ethanol and the ethyl acetate ranges 15 from 20 to 50 times a mass of the 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1,3-propanediol.2. The method of claim 1 , wherein the forming of the crystalline particles is carried out while stirring the second solution at a tip speed of not less than 50 m/min.3. The method of claim 1 , wherein the adding of the hydrochloric acid is carried out at a temperature in a range of from 60° ...

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Номер записи: 52
15-01-2015 дата публикации

METHOD FOR PRODUCING POLYTHIOL COMPOUND FOR OPTICAL MATERIALS AND COMPOSITION COMPRISING SAME FOR OPTICAL MATERIALS

Номер: US20150018507A1
Автор: Jang Dong Gyu, KIM Jong Hyo, Roh Soo Gyun
Принадлежит:

The present invention relates to a polythiol compound for a high quality optical material that exhibits excellent physical properties in terms of color, a composition for an optical material including the polythiol compound, a method for producing an optical material, and a method for preparing the polythiol compound. The method includes reacting an epichlorohydrin compound containing 0.5% by weight or less of impurities with 2-mercaptoethanol. The polythiol compound is prevented from being colored. The polythiol compound can be used to produce a urethane optical material that is prevented from being colored and has a low yellowness index and a good color. The polythiol compound can be used to produce various optical materials including urethane optical materials. The optical material can be used to manufacture an optical lens having a good color. The optical lens can be used as a spectacle lens, a polarizing lens, a camera lens, or the like. 1. A method for preparing a polythiol compound , comprising reacting an epichlorohydrin compound with 2-mercaptoethanol ,wherein the epichlorohydrin compound contains 0.5% by weight or less of impurities comprising acrolein, allyl chloride, 1,2-dichloropropane, 2,3-dichloropropene, 2-methyl-2-pentanol, 2-chloroallyl alcohol, cis-1,3-dichloropropene, trans-1,3-dichloropropene, 1,3-dichloroisopropanol, 1,2,3-trichloropropane and 2,3-dichloropropanol.2. A composition for an optical material comprising a polythiol compound prepared by the method according to .3. The composition according to claim 2 , further comprising a polyisocyanate compound.4. The composition according to claim 3 , wherein the polyisocyanate compound is selected from the group consisting of isophorone diisocyanate (IPDI) claim 3 , hexamethylene diisocyanate (HDI) claim 3 , dicyclohexyl methanediisocyanate (H12MDI) claim 3 , xylylene diisocyanate (XDI) claim 3 , 3 claim 3 ,8-bis(isocyanatomethyl)tricyclo[5 claim 3 ,2 claim 3 ,1 claim 3 ,02 claim 3 ,6]decane ...

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Номер записи: 53
17-01-2019 дата публикации

PROCESS FOR PREPARING ESTERS OF LACTIC ACID, AND 2-HYDROXY-3-BUTENOIC ACID OR ALPHA-HYDROXY METHIONINE ANALOGUES FROM SUGARS

Номер: US20190016674A1
Автор: TAARNING Esben, Zubiri Irantzu Sadaba
Принадлежит:

A continuous flow process for the preparation of one or more esters of lactic acid and 2-hydroxy-3-butenoic acid or α-hydroxy methionine analogues from a sugar in the presence of a solid Lewis acid catalyst and a solvent comprising an organic solvent and water. The invention provides a means for stabilizing a Lewis acid catalyst for use in a continuous reaction process wherein the water is present in an amount of up to or equal to 10 vol. % of the organic solvent. 1. A continuous flow process for the preparation of one or more esters of lactic acid and 2-hydroxy-3-butenoic acid from a sugar selected from one or more of the group consisting of glucose , fructose , mannose , sucrose , xylose , erythrose , erythrulose , threose and glycolaldehyde , in the presence of a solid Lewis acid catalyst and a solvent comprising an organic solvent and water , wherein the volume % of water present in the organic solvent is from 0.25 vol % to 10 vol. % , wherein the solid Lewis acid catalyst has a framework structure , which is selected from the group consisting of BEA , MFI , FAU , MOR , FER , MWW , MCM-41 and SBA-15.2. A process according to claim 1 , wherein the yield of the one or more lactic acid esters decreases by up to 0.25% per hour on stream on average claim 1 , wherein the yield is amount of ester relative to the amount of sugar.3. A process according to claim 1 , wherein the yield of the one or more lactic acid esters decreases by up to 0.10% per hour on average claim 1 , wherein the yield is amount of ester relative to the amount of sugar.4. A process according to claim 1 , wherein the yield of the one or more lactic acid esters decreases by up to 5% after 50 hours on stream claim 1 , wherein the yield is amount of ester relative to the amount of sugar.5. A process according to claim 1 , wherein the yield of the one or more lactic acid esters is greater than 40% after 50 hours on stream claim 1 , wherein the yield is amount of ester relative to the amount of sugar.6. ...

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Номер записи: 54
21-01-2021 дата публикации

METHOD FOR PRODUCING ORGANIC MERCAPTO COMPOUND OR INTERMEDIATE THEREOF, (POLY)THIOL COMPONENT, POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, MOLDED PRODUCT, OPTICAL MATERIAL, AND LENS

Номер: US20210017128A1
Автор: Kuboi Hironori, OHSHIMIZU Kaoru
Принадлежит: Mitsui Chemicals, Inc.

A method for producing an organic mercapto compound or an intermediate thereof according to the present invention has a reaction step of reacting an alcohol compound including a sulfur atom with a thioamide compound having a structure in which an organic group is bonded to at least one bonding hand of a thioamide group, under acidic conditions. 1. A method for producing an organic mercapto compound or an intermediate thereof , comprising:a reaction step of reacting an alcohol compound including a sulfur atom with a thioamide compound having a structure in which an organic group is bonded to at least one bonding hand of a thioamide group, under acidic conditions.2. The method for producing an organic mercapto compound or an intermediate thereof according to claim 1 ,{'sup': '2', 'wherein a topological polar surface area of the thioamide compound is 10.00 to 51.00 Å.'}4. The method for producing an organic mercapto compound or an intermediate thereof according to claim 3 ,{'sup': '1', 'wherein, in the compound represented by General Formula (2), Ris a monovalent aryl group having 6 to 10 carbon atoms, which optionally be substituted, a monovalent aliphatic group having 1 to 10 carbon atoms, which optionally be substituted, or a monovalent heteroaryl group having 3 to 10 carbon atoms, which optionally be substituted, and substituents of these groups optionally include a hetero atom, and'}{'sup': 2', '3', '2', '3, 'Rand Rare hydrogen atoms or Rand Rare bonded to each other to form a nitrogen-containing heterocyclic ring having 3 to 10 carbon atoms.'}5. The method for producing an organic mercapto compound or an intermediate thereof according to claim 1 , {'br': None, 'sup': '1', 'sub': 'n', 'Q\ue8a0OH\u2003\u2003(1)'}, 'wherein the alcohol compound is represented by General Formula (1),'}{'sup': '1', 'wherein in Formula (1), Qis an n-valent organic group including a sulfur atom and having 1 to 30 carbon atoms, and n is an integer of 1 to 10.'}7. The method for producing ...

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Номер записи: 55
21-01-2021 дата публикации

REFINED METHIONINE PRODUCTION METHOD

Номер: US20210017129A1
Автор: MORIMOTO Akira, SATOH YOSHITAKA, YAMASHIRO Naoya
Принадлежит: Sumitomo Chemical Company, Limited

An object of the present invention is to provide a refined methionine production method capable of achieving an improvement in washing efficiency. This production method is a method for producing refined methionine from a slurry of crude methionine and comprises (1) a step of separating the slurry of crude methionine into solid and liquid by using a continuous filter, (2) a step of spraying preliminary washing water on a crude cake obtained by separating the slurry of crude methionine into solid and liquid to wash the crude cake, and (3) a step of mixing a semi-refined cake obtained by spraying preliminary washing water on the crude cake to wash the crude cake with finishing washing water to wash the semi-refined cake. 1. A method for producing refined methionine from a slurry of crude methionine , the method comprising:a step of separating the slurry of crude methionine into solid and liquid by using a continuous filter;a step of spraying preliminary washing water on a crude cake resulting from solid liquid separation of the slurry of crude methionine, thereby washing the crude cake; anda step of mixing a semi-refined cake resulting from the washing by spraying preliminary washing water on the crude cake, with finishing washing water, thereby washing the semi-refined cake.2. The method according to claim 1 , wherein the semi-refined cake has a moisture content of 20 mass % to 40 mass %. This patent application claims priority under the Paris Convention based on Japanese Patent Application No. 2017-251240 (filed on Dec. 27, 2017) incorporated herein by reference in its entirety.The present invention relates to a refined methionine production method.There is disclosed, for example the following methionine production method, i.e, a method comprising hydrolyzing 5-(2-methylmercaptoethyl)hydantoin (hereinafter also referred to as methionine hydantoin) to obtain a liquid containing a methionine salt (hereinafter also referred to as a hydrolysis reaction liquid), and ...

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Номер записи: 56
26-01-2017 дата публикации

AMORPHOUS FORM OF A THIOCOLCHICINE DERIVATIVE

Номер: US20170022155A1
Автор: Cabri Walter, CICERI Daniele, Gambini Andrea, Peterlongo Federico
Принадлежит:

The present invention refers to an amorphous form of a thiocolchicine derivative, IDN 5404, to a process for producing it and to pharmaceutical compositions thereof. The amorphous form is characterised by the XRPD pattern, DSC profile and/or TG/DTA profile. 2. The amorphous compound according to having a DSC profile characterized by a glass transition with onset at 186.9° C. and endset at 194.5° C. recorded with a linear heating rate of 10° C./min.3. The amorphous compound according to having a TG/DTA profile characterized by an endothermic signal between 185.4° C. and 195.4° C. recorded with a linear heating rate of 10° C./min.4. A process of preparing the amorphous compound of formula (I) claim 1 , as defined in claim 1 , comprising the steps of:(a) dissolving the crude compound of formula (I) in DMSO;(b) removing the possible residual solvents coming from the synthetic process by heating the solution at 65° C. under vacuum;(c) precipitating the amorphous compound of formula (I) by adding drop wise the solution obtained in step b) to water at 20-25° C.5. A pharmaceutical composition comprising the amorphous compound of formula (I) according to and a pharmaceutically acceptable carrier and/diluent.6. The pharmaceutical composition according to for parenteral or oral administration.7. The pharmaceutical composition according to in form of injectable preparation.8. The amorphous compound of formula (I) according to claim 1 , for use in the treatment of solid tumors.9. Method of treating solid tumors in subjects in need thereof claim 1 , said method comprising administering an effective amount of the amorphous compound of formula (I) according to to said subjects; and treating said subjects of said solid tumors. The present invention refers to an amorphous form of a thiocolchicine derivative, IDN 5404, a process for its preparation and pharmaceutical compositions thereof.IDN 5404 having the following formula (I) is a N-deacetylthiocolchicinoid derivative:IDN 5404 acts ...

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Номер записи: 57
22-01-2015 дата публикации

Compounds and Methods for Use in Detecting Gabapentin

Номер: US20150024456A1
Автор: Helms Michael Kevin, Moon Byung Sook, Orozco Alejandro A., Valdez Johnny Jose
Принадлежит:

Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a signal producing system in gabapentin assays. 2. The compound of claim 1 , wherein said linker comprises 0 to 40 carbon atoms and 0-6 heteroatoms.3. The compound of claim 2 , wherein W is a lower alkyl and said linker is selected from the group consisting of{'sub': 2', 'n, '—(CH)C(O)—,'}{'sub': 2', 'n, '—C(O)(CH)—,'}{'sub': 2', 'n, '—C(O)(CH)NH—C(O)—,'}{'sub': 2', 'm', '2', 'n, '—C(O)(CH)NH—C(O)(CH)—,'}{'sub': 2', 'n', '2, '—(CH)SCHC(O)—,'}{'sub': 2', 'm', '2', '2', 'n, '—(CH)SCHC(O)(CH)—,'}{'sub': 2', 'm', '2', 'n, '—(CH)C(O)NH(CH)—,'}{'sub': 2', 'n, '—(CH)NH—C(O)—,'}{'sub': 2', 'm', '2', 'n, '—(CH)NH—C(O)(CH)—,'}{'sub': 2', 'n, '—C(O)—(CH)—, and'}{'sub': 2', 'n, '—(CH)—;'}wherein m, n, o, and p are independently selected from an integer from 0 to 10.4. The compound of claim 2 , wherein W is a carbonyl and said linker is selected from the group consisting of{'sub': 2', 'n, '—(CH)C(O)—,'}{'sub': 2', 'n', '2, '—(CH)SCHC(O)—,'}{'sub': 2', 'm', '2', '2', 'n, '—(CH)SCHC(O)(CH)—,'}{'sub': 2', 'm', '2', 'n, '—(CH)C(O)NH(CH)—,'}{'sub': 2', 'n, '—(CH)NH—C(O)—,'}{'sub': 2', 'm', '2', 'n, '—(CH)NH—C(O)(CH)—, and'}{'sub': 2', 'n, '—(CH)—;'}wherein m, n, o, and p are independently selected from an integer from 0 to 10.5. The compound of claim 1 , wherein W is a lower alkyl group and the lower alkyl group is a methyl group.6. The compound of claim 1 , wherein said reactive functional group is selected from the group consisting of halogen claim 1 , OH claim 1 , SH claim 1 , NH claim 1 , O-lower alkyl claim 1 , epoxy claim 1 , S-acyl claim 1 , carboxyl claim 1 , maleimidyl claim 1 , haloacetamide claim 1 , hydroxysuccinimidyl claim 1 , ...

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Номер записи: 58
24-04-2014 дата публикации

Surface Deposition-Type Honeycomb Catalyst For Flue Gas Denitrification and Preparation Method Thereof

Номер: US20140113802A1
Автор: Dong Li, Gao Shiqiu, Guo Feng, Wang Yin, Xu Guangwen, YANG Juan, Yu Jian
Принадлежит:

This invention relates to the cleaning of flue gas released from various combustion processes, particularly a surface deposition NH—SCR honeycomb catalyst and its preparation method. The catalyst is composed of framework material, TiO, VOand WO, wherein the framework material is composed of clay, coal ash, mineral waste residue or their mixture. The mass fractions for framework material, TiO, VO, and WOare 60 wt. % to 80 wt. %, 13 wt. % to 33 wt. %, 1 wt. % to 5 wt. %, and 0.1 wt. % to 2 wt. %, respectively. The nano VO—WO—TiOparticles were deposited on the surface of particle pore or honeycomb, and the performance of the catalyst could be greatly improved 1. A honeycomb catalyst for DeNOx prepared by surface deposition method , being composed of a honeycomb framework , TiOas an active carrier , VOand WOas the active components , wherein the said honeycomb framework is composed of clay , coal ash or mineral waste residue , the said active components are loaded on the said active carrier and the said active carrier is dispersed in the said honeycomb framework; the mass fractions of the said components are as follows: the said framework: 60˜80 wt. %; TiO: 13˜33 wt. %; WO: 1˜5 wt. %; VO: 0.1˜2 wt. %.2. The catalyst according to claim 1 , wherein the said catalyst further includes glass fiber of 1˜10 wt. % as molding promoter.3. The catalyst according to claim 1 , wherein the said clay is bentonite claim 1 , kaolin or atlapulgite claim 1 , and the basic oxides in the said clay is lower than 2 wt. % and has particle sizes of 10˜100 nm.4. A process for preparing a honeycomb catalyst for DeNOx based on the surface deposition method claim 1 , includes the following steps:{'sub': 2', '5', '3', '2, '(1) Preparing composite catalyst of VO—WO—TiO-transition carrier'}(1-1) Preparing a Ti-precursor solution including surfactant, wherein the concentration of the solution is 0.1˜5 mol/L and the surfactant of the solution is 1˜5 wt %;{'sub': '2', '(1-2) Adding porous combustion and ...

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Номер записи: 59
29-01-2015 дата публикации

CUCN-MEDIATED ONE POT PRODUCTION OF CINNAMONITRILE DERIVATIVES

Номер: US20150031899A1
Автор: Ahuja Brij Bhushan, Rekula Reddy Santosh, Sudalai Arumugam
Принадлежит:

The present invention discloses a cheaper and practical protocol for the construction of a wide variety of o-cyanocin-namonitrile and their structural analogues that proceeds with good yields in a single step using CuCN as the only reagent. 2. The process according to claim 1 , wherein said compound of formula I and CuCN are in the ratio of 1:2 to 1:3.3. The process according to claim 1 , wherein said isomers of compound of formula A are trans and cis isomers in the ratio of 3:1 to 10:1.4. The process according to claim 1 , wherein the reaction is carried out at a temperature ranging from 140 to 160° C.5. The process according to claim 1 , wherein the reaction is carried out for a time ranging from 10 to 15 hours.6. (canceled) 1. Field of InventionThe present invention relates to a cheaper and practical protocol for the preparation of compounds of formula A, its isomers and their structural analogues in a one pot and single step via hydrocyanation reaction of compound of general formula I with good yields.2. Description of Prior ArtAryl nitriles can be prepared by the cyanation of aryl halides with an excess of copper(I) cyanide in a polar high-boiling solvent such as DMF, nitrobenzene, or pyridine at reflux temperature using Rosenmund-von Braun Reaction.Alpha beta unsaturated nitriles are versatile reagents which have been used extensively in the synthesis of heterocycle compounds. Synthesis of cinnamonitrile by treating benzaldehyde with acetonitrile in presence of alkali is disclosed in Organic Syntheses, Coll. Vol. 7, p.108 (1990); Vol. 62, p.179 (1984). An article titled “Efficient One-Pot Synthesis of 2-Amino-4H-chromenes Catalyzed by Ferric Hydrogen Sulfate and Zr-Based Catalysts of FI” published in Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, Volume 41, Issue 9, 2011, wherein, the preparation of α-cyanocinnamonitrile is carried by the condensation of aldehyde with malononitrile to afford α-cyanocinnamonitrile derivatives by ...

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Номер записи: 60
17-02-2022 дата публикации

METHOD FOR PRODUCING METHIONINE

Номер: US20220048855A1
Автор: BINDERNAGEL Ulf, HIEROLD Judith, Moussallem Imad, Renner Christian, ROTH Philipp, SUDHOFF Daniel
Принадлежит: EVONIK OPERATIONS GMBH

The present invention pertains to a method for producing methionine or salts or derivatives thereof from hydrogen cyanide (HCN), the method comprising a step of producing 2-hydroxy-4-(methylthio)butyronitrile (MMP-CN), or a crude product mixture comprising MMP-CN, by contacting a hydrogen cyanide (HCN) process gas mixture prepared according to the Andrussow process from methane, ammonia and oxygen, with 3-methylmercaptopropionaldehyde (MMP), wherein the HCN process gas mixture is obtained from the crude HCN process gas mixture by adjusting the amount of ammonia to between 20% (v/v) and 60% (v/v) of the amount of the ammonia in the crude HCN process gas mixture. 17-. (canceled)8. A method for producing 2-hydroxy-4-(methylthio)butyronitrile (MMP-CN) , comprising: contacting a hydrogen cyanide (HCN) process gas mixture prepared according to the Andrussow process from methane , ammonia and oxygen , with 3-methylmercaptopropionaldehyde (MMP) , wherein the HCN process gas mixture is obtained from a crude HCN process gas mixture by adjusting the amount of ammonia to between 20% (v/v) and 60% (v/v) of the amount of the ammonia in the crude HCN process gas mixture.9. The method of claim 8 , wherein the ammonia adjustment is performed using an ammonia scrubber equipped with a bypass stream.10. The method of claim 8 , wherein the ammonia adjustment is performed using an ammonia scrubber enabling a partial ammonia breakthrough.11. The method of claim 8 , wherein the amount of ammonia in the HCN process gas mixture is adjusted to a maximum of 40% (v/v) of the ammonia in the crude HCN process gas mixture by passing a maximum of 40% (v/v) of the crude HCN gas mixture from the ammonia scrubber.12. A method for producing methionine or salts or derivatives thereof from HCN claim 8 , the method comprising: producing 2-hydroxy-4-(methylthio)butyronitrile (MMP-CN) claim 8 , or a crude product mixture comprising MMP-CN claim 8 , by contacting a hydrogen cyanide (HCN) process gas mixture ...

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Номер записи: 61
30-01-2020 дата публикации

Process for the purification of acrolein

Номер: US20200031751A1
Автор: Bruno Krudewig, Haohao Zhu, Martin Koerfer, Michael Eicker, Rainer Malzkorn, Thorsten MERKER
Принадлежит: EVONIK DEGUSSA GmbH

The present invention relates to a process for purifying acrolein. The process includes the steps of a) splitting a liquid feed stream containing acrolein into at least a first liquid stream and a second liquid stream, b) introducing the first liquid stream with a temperature T 1 into a distillation column at a point between the top and the bottom of the distillation column, c) introducing the second liquid stream with a temperature T 2 into the distillation column at the top of the distillation column, d) withdrawing an overhead vapor stream enriched in acrolein from the distillation column, and e) withdrawing a bottom stream depleted in acrolein. The temperature T 2 of the second liquid stream in step c) is lower than the temperature T 1 of the first liquid stream in step b).

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Номер записи: 62
30-01-2020 дата публикации

POLYOL OR POLYTHIOL COMPOUND, PREPARATION METHOD THEREFOR, TRANSPARENT POLYURETHANE-BASED RESIN PREPARED THEREFROM, AND OPTICAL BODY

Номер: US20200031986A1
Автор: Kim Keun Sik
Принадлежит:

The present invention relates to a novel polyol or polythiol having three or more functional groups, a preparation method there for, and an optical body manufactured therefrom. Especially, the present invention relates to a poly(thio)urethane-based resin and an optical body, such as lenses, manufactured using the resin, wherein the poly(thio)urethane-based resin is prepared by obtaining a novel polyol and then combining a polythiol, which is prepared from the obtained polyol, with a polyiso(thio)cyanate. 123-. (canceled)25. The polyol compound according to claim 24 , as represented by Formula (a) or (b) claim 24 , wherein Y is an oxygen atom; Ra is a methyl or ethyl group; and Rb is one substituent selected from the group consisting of the following substituents:{'sub': 2', '2', '2', '2', '2', '2', '2', '2, '—CHCH(OH)CHF, —CHCH(OH)CHCl, —CHCH(OH)CHBr, —CHCH(OH)CHI,'}{'sub': 2', '2', '2', '2', '2', '3, '—CHCH(OH)CHSCHCH(OH)CHSCHCH(OH)CH,'}{'sub': 2', '2', '2', '2', '3', '2, '—CHCH(OH)CHSCHCH(OH)CHSCH(CH)CHOH,'}{'sub': 2', '2', '2', '3, '—CHCH(OH)CHSCHCH(OH)CH,'}{'sub': 2', '2', '3', '2, '—CHCH(OH)CHSCH(CH)CHOH,'}{'sub': 2', '2', '2', '2', '3, '—CHCH(OH)CHSCHCH(OH)CHCH,'}{'sub': 2', '2', '2', '3', '2, '—CHCH(OH)CHSCH(CHCH)CHOH,'}{'sub': 2', '2', '2', '2', '2', '2', '3, '—CHCH(OH)CHSCHCH(OH)CHSCHCH(OH)CHCH, and'}{'sub': 2', '2', '2', '2', '2', '3', '2, '—CHCH(OH)CHSCHCH(OH)CHSCH(CHCH)CHOH.'}26. The polythiol compound according to claim 24 , as represented by Formula (a) or (b) claim 24 , wherein Y is a sulfur atom; Ra is a methyl or ethyl group; and Rb is one substituent selected from the group consisting of the following substituents:{'sub': 2', '2', '2', '2', '3', '2, '—CH(CHSH)CHSH, —CHCH(CHSH)SCH(CH)CHSH,'}{'sub': 2', '2', '2', '3', '2', '2', '3', '2, '—CHCH(CHSH)SCHCH(CH)SH, —CH(CHSH)CHSCH(CH)CHSH,'}{'sub': 2', '2', '2', '3, '—CH(CHSH)CHSCHCH(CH)SH,'}{'sub': 2', '2', '2', '3', '2, '—CHCH(CHSH)SCH(CHCH)CHSH,'}{'sub': 2', '2', '2', '2', '3, '—CHCH(CHSH)SCHCH(CHCH)SH ...

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Номер записи: 63
04-02-2021 дата публикации

THIOETHER PRECURSORS FOR FRAGRANT KETONES AND ALDEHYDES

Номер: US20210032562A1
Автор: FLACHSMANN Felix
Принадлежит:

Disclosed is a use of a compound of formula (I), a composition of matter comprising a compound of formula (I) and a consumer product comprising a compound of formula (I). 4. The method according to claim 1 , wherein the total combined number of carbon atoms of R claim 1 , R claim 1 , Rand Ris 1 to 6.5. The method according to claim 1 , wherein Ris H; Ris H; Ris H; and Ris methyl.6. The method according to claim 1 , wherein Ris H; Ris H; Ris methyl; and Ris methyl.7. The method according to claim 1 , wherein Ris methyl; Ris H; Ris H; and Ris methyl.8. The method according to claim 1 , wherein Ris methyl; Ris H; Ris methyl; and Ris methyl.9. The method according to claim 4 , wherein Ris a residue comprising 7 to 16 carbon atoms.10. The method according to claim 4 , wherein Ris an alkyl claim 4 , alkenyl or aromatic residue.11. The method according to claim 4 , wherein the compound of formula (I) is selected from the group consisting of 3-(octylthio)butanal claim 4 , 4-methyl-4-(octylthio)pentan-2-one claim 4 , 3-(decylthio)butanal claim 4 , 4-(decylthio)-4-methylpentan-2-one claim 4 , 4-(dodecylthio)pentan-2-one claim 4 , 4-(dodecylthio)-4-methylpentan-2-one claim 4 , 4-(dodecylthio)-3-methylpentan-2-one claim 4 , 3-(dodecylthio)-3-methylbutanal claim 4 , 3-(dodecylthio)butanal claim 4 , 3-(dodecylthio)-3-methylcyclohexan-1-one claim 4 , 3-(dodecylthio)-3-methylcyclopentan-1-one claim 4 , 3-(tetradecylthio)butanal and 4-methyl-4-(tetradecylthio)pentan-2-one claim 4 , 4-methyl-4-((6-methyloctyl)thio) pentan-2-one claim 4 , 3-((3-(4-isobutyl-2-methylphenyl)propyl)thio)butanal and 4-((3-(4-isobutyl-2-methylphenyl)propyl)thio)-4-methylpentan-2-one.12. A consumer product comprising a composition of matter according to .13. A consumer product according to claim 3 , wherein the concentration of the compound of formula (I) is 0.1% to 10%.14. The composition of matter according to claim 2 , wherein the amount of the compound of formula (A) in relation to the total amount of ...

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Номер записи: 64
05-02-2015 дата публикации

METHOD FOR MANUFACTURING REFINED METHIONINE

Номер: US20150038739A1
Автор: KOIZUMI Yoshiyuki, Nishida Junichi
Принадлежит: Sumitomo Chemical Company, Limited

The object of the present invention is to provide a process for producing refined methionine in which the loss of methionine due to washing is reduced. The present invention relates to a process for producing refined methionine from crude methionine, comprising a step of washing crude methionine with the use of a wash water containing methionine. 1. A process for producing refined methionine from crude methionine , comprising a step of washing crude methionine with the use of a wash water containing methionine.2. The process according to claim 1 , wherein the concentration of methionine in the wash water is 1.0% by weight or higher.3. The process according to claim 1 , wherein the wash water after being used for washing crude methionine is recovered and reused.4. The process according to claim 3 , wherein washing of crude methionine is performed with the use of an additional wash water together with the reuse of a part of the wash water after being used for washing crude methionine.5. The process according to claim 4 , wherein washing of crude methionine is performed by washing with the reused wash water claim 4 , followed by the washing with the additional wash water.6. The process according to claim 4 , wherein the additional wash water contains methionine.7. The process according to claim 6 , wherein the concentration of methionine in the additional wash water is 2.0% by weight or higher.8. The process according to claim 6 , wherein the additional wash water is substantially free from alkali.9. The process according to claim 6 , further comprising a step of drying refined methionine claim 6 , wherein the additional wash water is prepared by dissolving dried and refined methionine obtained in the step in pure water. The present invention relates to a process for producing a refined methionine from crude methionine, in particular a process for producing refined methionine in high yield by reducing the loss of methionine due to washing. Methionine is useful as an ...

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Номер записи: 65
09-02-2017 дата публикации

Metal-Catalyzed Oxidative Coupling of Thiols

Номер: US20170036998A1
Автор: Anantaneni Prakasa Rao, Harrington Ryan M., Laurent Boyd
Принадлежит: ECOLAB USA INC.

Disclosed are methods for preparing disulfide compounds through oxidative coupling of thiol compounds. Thiols are oxidized to the corresponding disulfide compound in high yield in presence of a base and a metal salt. The method uses low catalyst loadings and provides organic disulfide compounds with little to no byproducts. 2. The method of claim 1 , wherein the nickel salt is selected from the group consisting of nickel sulfate claim 1 , nickel acetate claim 1 , and a combination thereof.3. The method of claim 1 , wherein the organic base is triethylamine or triethanolamine.4. The method of claim 1 , wherein the molar ratio of the nickel salt to thiol is about 0.0005 to 1 or less.10. The method of claim 6 , wherein the nickel salt is selected from the group consisting of nickel sulfate claim 6 , nickel acetate claim 6 , and a combination thereof.11. The method of claim 6 , wherein the organic base is a tertiary amine.12. The method of claim 6 , wherein the molar ratio of the nickel salt to thiol is about 0.0005 to 1 or less.14. A method for producing a compound of formula (I) claim 6 , (II) claim 6 , or (III) or a salt thereof claim 6 , the method comprising:adding nitrogen to a reaction vessel comprising a thiol, a base, and a nickel salt;adding substantially pure oxygen to the reaction vessel after the nitrogen has been added; heating the reaction vessel;maintaining oxygen at the same pressure during reaction;wherein oxygen is added and maintained at a pressure less than the pressure of nitrogen.18. The method of claim 14 , wherein the nickel salt is selected from the group consisting of nickel sulfate claim 14 , nickel acetate claim 14 , and a combination thereof.19. The method of claim 14 , wherein the reaction vessel is maintained under an oxygen pressure of from about 50 psig to about 150 psig.20. The method of claim 14 , wherein the reaction vessel is maintained at a temperature of about 60° C. or less. This patent application claims the benefit of U.S. ...

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Номер записи: 66
12-02-2015 дата публикации

METHIONINE COMPOUND INTENDED FOR ANIMAL FEED

Номер: US20150045434A1
Автор: Fiey Guillaume
Принадлежит: ROQUETTE FRERES

The present invention relates to a novel liquid methionine composition, originating from the mother liquor from crystallization of methionine produced by fermentation, comprising between 30 and 50% by weight of methionine and having a dry matter comprised between 20% and 75% by weight and characterized in that it also comprises less than 0.5% by weight of isoleucine and between 0.9% and 1.3% of N-acetyl-methionine. 17-. (canceled)8. A liquid methionine composition , derived from the mother liquor of crystallization of methionine produced by fermentation which comprises from 30% to 50% by weight of methionine , and which has a dry matter content between 20% and 75% by weight.9. The composition of claim 8 , which comprises less than 0.5% by weight of isoleucine and between 0.9% and 1.3% by weight of N-acetyl-methionine.10. The composition of claim 8 , wherein the content of amino acids other than methionine and isoleucine is between 7% and 10% by weight.11. The composition of claim 8 , wherein the sugar content is less than 5%.12. A process for preparing a composition of claim 8 , which comprises the following steps from the fermentation medium of a methionine-producing microorganism:a) clarification of the fermentation medium and removal of insoluble and soluble organic impurities from said fermentation medium,b) optionally, demineralization of the clarified fermentation medium to remove cations and anions from said fermentation medium,c) crystallization of methionine from the liquid solution thus obtained, and recovery of the crystallization mother liquor,d) adjustment of the pH of the crystallization mother liquor so as to situate at a value of pHpKa2 of methionine,e) optionally, filtration, and concentration of said solution, andf) recovery of the methionine composition thus obtained.13. A method for preparing a food additive or a supplement for animal feed which comprises mixing the composition of with another food.14. A ...

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Номер записи: 67
18-02-2021 дата публикации

METHOD OF PRODUCING FLUORINE-CONTAINING SULFIDE COMPOUNDS

Номер: US20210047265A1
Автор: IKETANI Yoshihiko, KASHIKURA Wataru, SATO Yuki
Принадлежит:

The present invention aims to provide a method by which fluorine-containing sulfide compounds, particularly sulfide compounds that contain hydrogen and fluorine, can be produced in a simple, low-cost and industrial manner. Provided is a method of producing a fluorine-containing sulfide compound represented by the following formula (2): 16-. (canceled)9. The method of producing a fluorine-containing sulfide compound according to claim 7 , wherein 1.0 to 20.0 equivalents of the fluorinating agent relative to the chlorine-containing sulfide compound is used in terms of the substance's quantitative ratio.10. The method of producing a fluorine-containing sulfide compound according to claim 7 , wherein the reaction is performed at a temperature of 50 to 350° C.11. The method of producing a fluorine-containing sulfide compound according to claim 7 , wherein the chlorine-containing sulfide compound and the fluorinating agent are vaporized before being supplied to a reactor.12. The method of producing a fluorine-containing sulfide compound according to claim 7 , wherein the at least one selected from the group consisting of metal fluorides supported on activated charcoal claim 7 , metal chlorides supported on activated charcoal claim 7 , and metal catalysts supported on activated charcoal is at least one selected from the group consisting of chromium fluoride claim 7 , nickel fluoride claim 7 , copper fluoride claim 7 , silver fluoride claim 7 , sodium fluoride claim 7 , potassium fluoride claim 7 , cesium fluoride claim 7 , chromium chloride claim 7 , nickel chloride claim 7 , chromium claim 7 , copper claim 7 , zinc claim 7 , silver claim 7 , magnesium claim 7 , and titanium claim 7 , all of which is supported on activated charcoal.13. The method of producing a fluorine-containing sulfide compound according to claim 7 , wherein the chlorine-containing sulfide compound is CH-S-CCl claim 7 , and the fluorine-containing sulfide compound is CH-S-CF.14. The method of producing ...

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Номер записи: 68
18-02-2016 дата публикации

METHOD FOR THE PREPARATION OF (3S,3S') 4,4'-DISULFANEDIYLBIS (3-AMINOBUTANE 1-SULFONIC ACID)

Номер: US20160046571A1
Автор: Balavoine Fabrice, Cartigny Yohann, Coquerel Gerard, Couvrat Nicolas, Madec Jonathan, Petit Marie-Noelle, Schneider Jean-Marie
Принадлежит:

The present invention relates to a new method for the preparation of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A. 1. A trihydrate form of (3S ,3S′) 4 ,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid).2. A trihydrate form of (3S ,3S′) 4 ,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) formed from (3S ,3S′) neopentyl 4 ,4′-disulfanediylbis(3-(benzyloxycarbonylamino)butane 1-sulfonate).3. A trihydrate form of (3S ,3S′) 4 ,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) formed from (S) ethyl 2-(benzyloxycarbonylamino) 4-(neopentyloxysulfonyl)butanoate4. A crystalline (3S ,3S′) 4 ,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid)trihydrate , which has a powder XRD diffractogram with characteristic peaks at approximately: 5.09; 14.30; 15.30; 18.32 degrees 2θ (K_alpha1 Cu anode).5. A crystalline (3S ,3S′) 4 ,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid)trihydrate , which has a powder XRD diffractogram with characteristic peaks at approximately: 5.09; 14.30; 15.30; 18.32; 22.09; 22.79; 24.65; 25.60 and 25.83 degrees 2θ (K_alpha1 Cu anode).6. A crystalline (3S ,3S′) 4 ,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid)trihydrate , which has a powder XRD diffractorgram as essentially depicted in .8. The trihydrate of prepared according to a method comprising the steps of:(a) reducing the ethyl ester of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) from (S) ethyl 2-(benzyloxycarbonylamino) 4-(neopentyloxysulfonyl)butanoate to give (S) neopentyl 3-(benzyloxycarbonylamino) 4-hydroxybutane 1-sulfonate B;(b) reacting the alcohol B with methanesulfonic anhydride or methanesulfonyl chloride in presence of a base to give (S) neopentyl 3-(benzyloxycarbonylamino) 4-(methylsulfonyloxy)butane 1-sulfonate C;(c) reacting the mesylated alcohol C with potassium thioacetate to give (S) 2-(benzyloxycarbonylamino) 4-(neopentyloxysulfonyl)butyl thioacetate D ...

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Номер записи: 69
15-02-2018 дата публикации

METHOD FOR CONTINUOUS PREPARATION OF HIGH BULK DENSITY METHIONINE CRYSTAL

Номер: US20180043281A1
Автор: Chen Cong, Chen Zhirong, LI Yin, Wang Cunchao, Wang Zhengjiang, Wang Zhixuan, Zhang Zhixiang
Принадлежит:

The present disclosure relates to a method for continuous preparation of high bulk density methionine crystals. The process of the method is as follows: a hydrolysate solution, which is obtained from a reaction of 5-(β-methylmercaptoethyl) hydantoin and a potassium carbonate solution, is mixed with an external circulation material from a DTB neutralization crystallizer having a gas phase neutralization section; after being cooled, the mixture enters a liquid distributor of a neutralization region in the upper part of the crystallizer and is sprayed in the form of liquid droplet or trickle into carbon dioxide gas for neutralization reaction, and then naturally falls into a crystallization region in the lower part to be mixed with a material in the region; the obtained mixture grows on fine crystals in a system to form crystals having larger particle diameters, and meanwhile new crystal nucleuses are formed; in a deposition area in the middle part of the crystallization region, the crystals having larger particle diameters deposits into an elutriation leg, while the fine crystals circulate with the external circulation material, and a part of the external circulation material is used to elutriate the crystals in the elutriation leg, while another part of the same is used to be mixed with the hydrolysate solution; and the crystals in the elutriation leg are separated, washed and dried to obtain the high bulk density methionine product. 1. A method for continuous preparation of high bulk density methionine crystals , comprising the following steps:(1) mixing a hydrolysate solution containing potassium methionine obtained from a reaction of 5-(β-methylmercaptoethyl)hydantoin and a potassium carbonate solution with an external circulation material from a DTB neutralization crystallizer having a gas phase neutralization section to form a mixture material; the mixture material entering a liquid distributor of a neutralization region in an upper part of the crystallizer ...

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Номер записи: 70
19-02-2015 дата публикации

PROCESS FOR THE PREPARATION OF METHIONINE

Номер: US20150051421A1
Автор: DRAPAL Bernd, Hasselbach Hans Joachim, HUTHMACHER Klaus, Jakob Harald, Koerfer Martin, Krull Horst, PETER Rainer, REICHERT Stefan, WECKBECKER Christoph
Принадлежит: Evonik Industries AG

The invention relates to a process for the preparation of D,L-methionine, in which carbon dioxide is fed to an aqueous potassium methioninate solution obtained by hydrolysis of 5-(2-methylmercaptoethyl)hydantoin, in order to precipitate out crude methionine, which is separated off and purified, where, for the purposes of purification, an aqueous solution of the separated-off crude methionine is prepared and subjected to a recrystallization, characterized in that the solution from which the recrystallization takes place contains potassium ions and also a crystallization additive, where the crystallization additive is a nonionic or anionic surfactant, or a mixture of different nonionic or anionic surfactants, and that the recrystallization takes place by introducing a 60 to 110° C.-hot methionine solution into a 35 to 80° C.-warm methionine suspension, the temperature of which is lower than that of the introduced solution, the temperature of the methionine suspension being maintained between 35 and 80° C. during the addition. 1. A process for the preparation of D ,L-methionine , comprising feeding carbon dioxide to an aqueous potassium methioninate solution obtained by hydrolysis of 5-(2-methylmercaptoethyl)hydantoin , in order to precipitate out crude methionine , which is separated off and purified , wherein , for purification , an aqueous solution of the separated-off crude methionine is prepared and subjected to a recrystallization , wherein the solution from which the recrystallization takes place comprises potassium ions and also a crystallization additive , where the crystallization additive is a nonionic or anionic surfactant , or a mixture of different nonionic or anionic surfactants , and the recrystallization takes place by introducing a 60 to 110° C.-hot methionine solution into a 35 to 80° C.-warm methionine suspension , a temperature of which is lower than that of the introduced solution , the temperature of the methionine suspension being maintained ...

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Номер записи: 71
14-02-2019 дата публикации

PROCESS FOR PREPARING AMINOTHIOL ESTER COMPOUNDS AND SALTS THEREOF

Номер: US20190047948A1
Автор: DE CARNE-CARNAVALET Benoit, Rool Patrice
Принадлежит: ADVANCED BIODESIGN

A process for preparing aminothiol ester compounds and salts thereof. The present invention relates to a process for preparing compounds of formula (I), (I) comprising the following steps: a) reacting a compound of formula (II) with an inorganic acid or an organic acid, (II) b) reacting the compound obtained in step a) with a base; c) reacting the compound obtained in step b) with CO; d) reacting the compound obtained in step c) with an alkyl chloroformate, a reagent capable of forming, with the compound obtained in step c), an acid halide, or a reagent capable of forming, with the compound obtained in step c), a mixed anhydride; e) reacting the compound obtained in step d) with an SMe anion precursor compound. 2. Method according to claim 1 , wherein the compound of formula (II) is obtained by a step a1) of reaction of 3-chloro-3-methylbut-1-yne with XXNH in an aqueous medium.3. Method according to claim 2 , wherein the compound obtained in step a1) is purified by one or more filtrations.4. Method according to claim 2 , wherein the 3-chloro-3-methylbut-1-yne is obtained by a step a0) of reaction of 2-methylbut-3-yn-2-ol with hydrochloric acid in the presence of a copper catalyst.5. Method according to claim 1 , wherein the acid is an inorganic acid selected from the group consisting of hydrochloric acid claim 1 , phosphoric acid claim 1 , nitric acid claim 1 , and sulfuric acid.6. Method according to claim 1 , wherein the base of step b) has a pKa greater than 25.7. Method according to claim 1 , wherein step d) is implemented with:an alkyl chloroformate having a 1-6 carbon alkyl, which may comprise at least one double bond; ora reagent capable of forming with the compound obtained in stage c) a mixed anhydride chosen from acid chlorides; or{'sub': 2', '2', '3', '5', '3', '3', '2, 'a reagent capable of forming with the compound obtained in stage c) an acid halide selected from the group consisting of SOCl, COCl, PCl, PCl, PBrand PPhBr.'}8. Method according to claim ...

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Номер записи: 72
25-02-2016 дата публикации

ORGANOCATALYSTS OF OXIDATIVE PROTEIN FOLDING

Номер: US20160052878A1
Автор: III John C., Lukesh, RAINES Ronald T.
Принадлежит:

Catalysts of protein-disulfide isomerization of formula: 2. The compound of claim 1 , wherein the calculated logP of (CH)NRis greater than or equal to 0.3. The compound of claim 1 , wherein each Rand each Rare hydrogens.4. The compound of claim 1 , wherein Ris —COR.5. The compound of claim 4 , wherein Ris an alkyl group having 1-20 carbon atoms or an alkenyl group having 3-20 carbon atoms.6. The compound of claim 4 , wherein Ris an alkyl group having 1-6 carbon atoms.7. The compound of claim 4 , wherein Ris an aromatic group having 6-12 carbon atoms.8. The compound of claim 4 , wherein Ris a cyclopentyl claim 4 , cyclohexyl claim 4 , cyclooctyl claim 4 , cyclononyl claim 4 , cyclodecyl claim 4 , cyclopentenyl claim 4 , cyclohexenyl claim 4 , cyclooctenyl claim 4 , cyclononenyl or cyclodecenyl group.9. The compound of claim 4 , wherein Ris a phenyl claim 4 , benzyl claim 4 , biphenyl claim 4 , naphthyl claim 4 , indanyl or indenyl group.10. The compound of claim 4 , wherein Ris an alkyl-substituted phenyl group.11. The compound of claim 1 , wherein R claim 1 , each Rand each of Rare hydrogens.12. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris an unsubstituted straight-chain or branched alkyl group having 3-6 carbon atoms.13. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris a phenyl claim 1 , benzyl claim 1 , phenethyl claim 1 , or an alkyl-substituted phenyl group.14. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris an unsubstituted cycloalkyl group having 5-8 carbon atoms.15. The compound of claim 1 , wherein each Ris —COR.16. The compound of claim 1 , wherein each Ris —COR claim 1 , each Ris hydrogen and Ris —COR.17. A refolding buffer comprising one or more compounds of .18. A method for forming a disulfide bond in a polypepetide or protein containing at least two cysteines which comprises contacting the ...

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Номер записи: 73
22-02-2018 дата публикации

Process for Conversion of Dimethyl Sulfide to Methyl Mercaptan

Номер: US20180050986A1
Автор: BARRY Christina M., HANKINSON Michael S., HASENBERG Daniel M., HWU Henry, KHANKAL Reza, Refvik Mitchell D.
Принадлежит:

Disclosed herein are systems and processes involving the catalyzed cleavage reaction of dimethyl sulfide to methyl mercaptan. The catalyzed cleavage reaction can be a standalone system or process, or can be integrated with a methyl mercaptan production plant. 1. A process for conversion of dimethyl sulfide to methyl mercaptan , comprising:contacting dimethyl sulfide in a combined feed stream with a catalyst in the presence of an excess amount of hydrogen sulfide in a reactor to yield a reactor effluent comprising methyl mercaptan, hydrogen sulfide, and carbon disulfide, wherein the catalyst comprises alumina, NiMo on an alumina support, CoMo on an alumina support, or a combination thereof:wherein the step of contacting has, in the reactor effluent, a conversion of dimethyl sulfide of greater than 50% and a selectivity to methyl mercaptan of greater than 95%.2. The process of claim 1 , wherein carbon disulfide is present in the reactor effluent in an amount of less than about 2 mole % based on a total moles of methyl mercaptan claim 1 , hydrogen sulfide claim 1 , dimethyl disulfide claim 1 , and carbon disulfide in the reactor effluent.3. (canceled)4. The process of claim 1 , further comprising:{'sub': '2', 'separating the reactor effluent into a recycle HS stream and a methyl mercaptan stream; and'}{'sub': '2', 'recycling the recycle HS stream for use in the step of contacting.'}5. The process of claim 1 , wherein the step of contacting is performed at a hydrogen sulfide to dimethyl sulfide mole ratio of at least 3:1 and less than 100:1.6. The process of claim 1 , wherein the step of contacting is performed at a weight average temperature in a range of from about 265° C. to about 305° C.7. The process of claim 1 , wherein the step of contacting is performed at a weight hourly space velocity of about 0.2 to about 15 g dimethyl sulfide/g cat./hr.8. The process of claim 1 , wherein the step of contacting is performed at a hydrogen sulfide to dimethyl sulfide mole ratio ...

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Номер записи: 74
02-03-2017 дата публикации

Novel Diamine Compound, and Polyamic Acid and Polyimide Using the Same

Номер: US20170058082A1
Автор: Choi Myeon Cheon, Ha Chang-Sik, Jeong Keuk Min, Kumar Tapaswi Pradip
Принадлежит:

Provided are a diamine compound, a polyamic acid and polyimide using the same. The diamine monomer compound is useful for preparing a transparent polyamic acid and polyimide having a high refractive index and a low birefringence. 2. The diamine monomer compound of claim 1 , wherein Lis each independently S or Se claim 1 , and Lis each independently selected from the group consisting of phenylene claim 1 , naphthylene claim 1 , biphenylene claim 1 , terphenylene claim 1 , anthrylene claim 1 , indenylene claim 1 , fluorenylene claim 1 , phenanthrylene claim 1 , triphenylenylene claim 1 , pyrenylene claim 1 , furylene claim 1 , thiophenylene claim 1 , pyrrolylene claim 1 , pyranylene claim 1 , imidazolylene claim 1 , pyrazolylene claim 1 , thiazolylene claim 1 , thiadiazolylene claim 1 , isothiazolylene claim 1 , triazinylene claim 1 , tetrazinylene claim 1 , triazolylene claim 1 , tetrazolylene claim 1 , furazanylene claim 1 , pyridinylene claim 1 , pyrazinylene claim 1 , benzofuranylene claim 1 , and benzothiophenylene.7. The preparation method of claim 5 , wherein Lis each independently S or Se claim 5 , and Lis each independently selected from the group consisting of phenylene claim 5 , naphthylene claim 5 , biphenylene claim 5 , terphenylene claim 5 , anthrylene claim 5 , indenylene claim 5 , fluorenylene claim 5 , phenanthrylene claim 5 , triphenylenylene claim 5 , pyrenylene claim 5 , furylene claim 5 , thiophenylene claim 5 , pyrrolylene claim 5 , pyranylene claim 5 , imidazolylene claim 5 , pyrazolylene claim 5 , thiazolylene claim 5 , thiadiazolylene claim 5 , isothiazolylene claim 5 , triazinylene claim 5 , tetrazinylene claim 5 , triazolylene claim 5 , tetrazolylene claim 5 , furazanylene claim 5 , pyridinylene claim 5 , pyrazinylene claim 5 , benzofuranylene claim 5 , and benzothiophenylene.8. A polymer material obtained by a polymerization reaction using the diamine monomer compound of .11. The polyamic acid of claim 9 , is obtained by a polymerization ...

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Номер записи: 75
22-05-2014 дата публикации

ORGANOACTINIDE-, ORGANOLANTHANIDE-, AND ORGANOGROUP-4-MEDIATED HYDROTHIOLATION OF TERMINAL ALKYNES WITH ALIPHATIC, AROMATIC AND BENZYLIC THIOLS

Номер: US20140142319A1
Автор: Marks Tobin J., Weiss Charles J., Wobser Stephen D.
Принадлежит: Northwestern University

An efficient and highly Markovnikov selective organoactinide-, organolanthanide-, and organozirconium-catalyzed addition of aryl, benzyl, and aliphatic thiols to terminal alkynes is described. The corresponding vinyl sulfides are produced with little or no side-products. 2. A vinyl sulfide of wherein the catalyst is selected from CpSmN(TMS) claim 1 , MeSiCp″Th[CH(TMS)]. CGCZrMe claim 1 , CpYCH(TMS) claim 1 , MeSiCp″UBn claim 1 , CpZrMe claim 1 , CGCSmN(TMS) claim 1 , CGCU(NMe) claim 1 , Cp*ZrBn claim 1 , La[N(TMS)] claim 1 , CGCTh(NMe) claim 1 , Zr[NMe] claim 1 , Nd[N(TMS)] claim 1 , U(NEt) claim 1 , Cp*ZrClNMe claim 1 , Lu[CH(TMS)] claim 1 , CpU(NMe) claim 1 , Y[N(TMS)] claim 1 , CpTh(CHTMS) claim 1 , CpLaCH(TMS) claim 1 , CpU(CHTMS) claim 1 , CpSmCH(TMS) claim 1 , and CpLuCH(TMS).3. A vinyl sulfide according to selected from the group consisting ofa) hex-1-en-2-yl(pentyl)sulfane;b) cyclohexyl(hex-1-en-2-yl)sulfane;c) hex-1-en-2-yl(4-methylbenzyl)sulfane;d) pentyl(1-phenylvinyl)sulfane;e) (1-(cyclohex-1-en-1-yl)vinyl)(pentyl)sulfanef) (1-cyclohexylvinyl)(pentyl)sulfane;g) (1-cyclohexylvinyl)(4-methylbenzyl)sulfane;h) ethyl(hex-1-en-2-yl)sulfane;i) hex- 1-en-2-yl(2,2,2-trifluoroethyl)sulfane;j) benzyl(hex-1-en-2-yl)sulfane;k) (3-cyclohexylprop-1-en-2-yl)(pentyl)sulfane;l) pentyl(3-phenylprop-1-en-2-yl)sulfane;m) 3-(1-(pentylthio)vinyl)pyridine; andn) 2-(pentylthio)prop-2-en-1-amine. This application is a divisional of and claims priority to U.S. application Ser. No. 12/856,154 filed Aug. 13, 2010, which claimed priority to U.S. provisional application Ser. 61/233,541 filed Aug. 13, 2009-each of which is incorporated herein by reference in its entirety.This invention was made with government support under Grant No. CHE0809589 awarded by the National Science Foundation. The government has certain rights in the invention.The present invention relates generally to atom-efficient organoactinide-, organolanthanide-, and organoGroup-4-catalyzed intermolecular ...

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Номер записи: 76
22-05-2014 дата публикации

LIQUID-LIQUID EXTRACTION COLUMN CONTAINING TWO DISTINCT TYPES OF PLATES

Номер: US20140142342A1
Автор: AUGIER Frederic, BAUDOT Arnaud, Digne Romina, LEINEKUGEL LE COCQ Damien
Принадлежит:

The present invention describes a liquid-liquid extraction column with perforated plates and downpipes, having a majority of so-called “open” plates and a minority of so-called “closed” plates, the two types of plates differing in the degree of perforation. Application of the said column to the treatment of liquid-liquid systems with time-variable coalescence. 1. Counter-current liquid-liquid extraction column having perforated plates with downpipes requiring a limited number of theoretical stages between 2 and 4 , and within which the partition coefficient of the solute to be extracted is greater than or equal to 50 , wherein the liquid-liquid system may have a time-variable coalescence , the said column comprising two distinct types of plates , namely a number of open plates between 1 and 25 , defined by a degree of perforation p % of between 2% and 6% , and a number of closed plates between 1 and 3 , the column being characterised in that:each closed plate is defined by a degree of perforation between 0.3 and 0.5 times that of the open plates,each closed plate is situated between two open plates, and{'b': 1', '2', '1', '2, 'the closed plates are situated in the middle part of the column, that is to say by dividing the latter into two substantially equal portions, numbered and from the top downwards, in the lower part of the portion or the upper part of the portion ,'}the downpipes associated with the closed plates have cross-sections between 0.25 and one times those of the downpipes of the open plates.2. Liquid-liquid extraction column according to in which a closed plate occupies the space corresponding to two open plates claim 1 , and in this case the downpipe associated with the said closed plate comprises a part crossing the column substantially along a diameter claim 1 , so that the outlet of the said downpipe is located opposite its inlet.3. Liquid-liquid extraction column according to claim 1 , in which a packing layer intended to promote coalescence is ...

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Номер записи: 77
28-02-2019 дата публикации

PROCESS FOR PREPARING LACTIC ACID ESTERS FROM SUGARS

Номер: US20190062271A1
Автор: TAARNING Esben, Zubiri Irantzu Sadaba
Принадлежит:

A continuous flow process for the preparation of one or more esters of lactic acid and 2-hydroxy-3-butenoic acid or α-hydroxy methionine analogues from a sugar in the presence of a solid Lewis acid catalyst and a solvent comprising an organic solvent and water. The invention provides a means for stabilizing a Lewis acid catalyst for use in a continuous reaction process wherein the water is present in an amount of up to or equal to 10 vol. % of the organic solvent. 1. A continuous flow process for the preparation of an α-hydroxy methionine analogue from a sugar selected from one or more of the group consisting of glucose , fructose , mannose , sucrose , xylose , erythrose , erythrulose , threose and glycolaldehyde , in the presence of a compound comprising sulphur , solid Lewis acid catalyst and a solvent comprising an organic solvent and water , wherein the water is present in an amount of up to or equal to 10 vol. % of the organic solvent , and wherein the solid Lewis acid catalyst has a framework structure , which is selected from the group consisting of BEA , MFI , FAU , MOR , FER , MWW , MCM-41 and SBA-15.2. The process according to claim 1 , wherein the compound comprising sulfur is selected from the group consisting of C-Calkyl thiol claim 1 , C-Calkyl thiol salts claim 1 , dimethylmercaptan and dimethyl disulfide.3. The process according to claim 1 , wherein the vol. % of water present in the organic solvent is from 0.25 to 10 vol. %.4. A process according to claim 1 , wherein the solid Lewis acid catalyst is calcined after 450 hours.5. A process according to claim 1 , wherein the solid Lewis acid comprises an active metal selected from one or more of the group consisting of Sn claim 1 , Ti claim 1 , Pb claim 1 , Zr claim 1 , Ge and Hf.6. A process according to claim 1 , wherein the solid Lewis acid catalyst is selected from the group consisting of Sn-BEA claim 1 , Sn-MFI claim 1 , Sn-FAU claim 1 , Sn-MOR claim 1 , Sn-MWW claim 1 , Sn-MCM-41 and Sn-SBA-15.7. ...

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Номер записи: 78
17-03-2022 дата публикации

METHODS OF PREPARING SUBSTITUTED INDANES

Номер: US20220081407A1
Автор: Spencer Stacey Renee, STENGEL Peter J., Xu Rui
Принадлежит: Peloton Therapeutics, Inc.

This application discloses methods for the synthesis of substituted indane analogs that modulate HIF-2α activity, as well as key intermediates produced thereby. The synthesis of 3-(((1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile was exemplified. 12-. (canceled)315-. (canceled)1618-. (canceled)1934-. (canceled)3536-. (canceled)3760-. (canceled)6166-. (canceled)6771-. (canceled)72. (canceled)74. (canceled)7680-. (canceled) This application is a U.S. non-provisional application which claims the benefit of provisional Application No. 62/901,669, filed Sep. 17, 2019.An adequate supply of oxygen to tissues is essential in maintaining mammalian cell function and physiology. A deficiency in oxygen supply to tissues is a characteristic of a number of pathophysiologic conditions in which there is insufficient blood flow to provide adequate oxygenation. The hypoxic (low oxygen) environment of tissues activates a signaling cascade that drives the induction or repression of the transcription of a multitude of genes implicated in events such as angiogenesis (neo-vascularization), glucose metabolism, and cell survival/death. A key to this hypoxic transcriptional response lies in the transcription factors, the hypoxia-inducible factors (HIF). HIFs are dysregulated in a vast array of cancers through hypoxia-dependent and independent mechanisms and expression is associated with poor patient prognosis.HIFs consist of an oxygen-sensitive HIFα subunit and a constitutively expressed HIFβ subunit. When HIFs are activated, the HIFα and HIFβ subunits assemble a functional heterodimer (the a subunit heterodimerizes with the β subunit). Both HIFα and HIFβ have two identical structural characteristics, a basic helix-loop-helix (bHLH) and PAS domains (PAS is an acronym referring to the first proteins, PER, ARNT, SIM, in which this motif was identified). There are three human HIFα subunits (HIF-1α, HIF-2α, and HIF-3α) that are oxygen ...

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Номер записи: 79
10-03-2016 дата публикации

PROCESS FOR THE PREPARATION OF METHIONINE

Номер: US20160068480A1
Автор: DRAPAL Bernd, Hasselbach Hans Joachim, HUTHMACHER Klaus, Jakob Harald, Koerfer Martin, Krull Horst, PETER Rainer, REICHERT Stefan, WECKBECKER Christoph
Принадлежит: Evonik Industries AG

This disclosure relates to a process for preparing D,L-methionine by feeding carbon dioxide to an aqueous potassium methioninate solution obtained by hydrolysis of 5-(2-methylmercaptoethyl)hydantoin, in order to precipitate out crude methionine, which is separated off and purified. In this process an aqueous solution of the separated-off crude methionine is purified by recrystallization from a solution containing potassium ions and also a crystallization additive. The crystallization additive is a nonionic or anionic surfactant, or a mixture of different nonionic or anionic surfactants. The recrystallization occurs by introducing a 60 to 110° C.-hot methionine solution into a 35 to 80° C.-warm methionine suspension, a temperature of which is lower than that of the introduced solution, such that the temperature of the methionine suspension being maintained between 35 and 80° C. during the addition. The crystallization additive is a sorbitan fatty acid ester or a mixture of different sorbitan fatty acid esters. 1. A process for preparing D ,L-methionine , the process comprising feeding carbon dioxide to an aqueous potassium methioninate solution obtained by hydrolysis of 5-(2-methylmercaptoethyl)hydantoin , in order to precipitate out crude methionine , which is separated off and purified ,wherein:an aqueous solution of the separated-off crude methionine is purified by recrystallization from a solution comprising potassium ions and also a crystallization additive;the crystallization additive is a nonionic or anionic surfactant, or a mixture of different nonionic or anionic surfactants;the recrystallization takes place by introducing a 60 to 110° C.-hot methionine solution into a 35 to 80° C.-warm methionine suspension, a temperature of which is lower than that of the introduced solution, the temperature of the methionine suspension being maintained between 35 and 80° C. during the addition; andthe crystallization additive is a sorbitan fatty acid ester or a mixture of ...

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Номер записи: 80
08-03-2018 дата публикации

INTRODUCTION OF ALKYL SUBSTITUENTS TO AROMATIC COMPOUNDS

Номер: US20180065904A1
Автор: Pappo Doron, PARNES Regev
Принадлежит:

Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane. 2. The process of claim 1 , wherein Ris ethyl.3. The process of claim 1 , wherein said acidic catalyst is one or more Lewis acid selected from the group consisting of: CuCl claim 1 , Sc(OTf) claim 1 , Fe(OTf) claim 1 , In(OTf) claim 1 , BF3.OEt claim 1 , and Cu(OTf).4. The process of claim 1 , wherein said acidic catalyst is one or more Brønsted acids selected from the group consisting of: Triflic acid (TfOH) claim 1 , para-toluenesulfonic acid claim 1 , and trifluoroacetic acid.5. The process of claim 1 , wherein said suitable solvent is a polar solvent selected from the group consisting of: acetonitrile claim 1 , nitromethane claim 1 , and 2 claim 1 ,2 claim 1 ,2-trifluoroethanol (TFE) claim 1 , hexafluoroisopropanol (HFIP) or a mixture thereof.6. The process of claim 1 , characterized by at least 30% yield of the compound represented by Formula I.8. The process of claim 7 , wherein said reducing agent is a silane.9. The process of claim 8 , wherein said silane is EtSiH.14. A pharmaceutical composition comprising a product according to and a pharmaceutically acceptable excipient.15. A composition comprising:{'sub': 2', '3', '3', '3', '3', '2', '2, '(i) one or more Lewis acids selected from the group consisting of: CuCl, Sc(OTf), Fe(OTf), In(OTf), BF.OEt, TfOH and Cu(OTf);'}(ii) a polar solvent selected from the group consisting of: acetonitrile, nitromethane, and 2,2,2-trifluoroethanol (TFE), or a mixture thereof; and(iii) RSH, wherein R is selected from the group consisting of: alkyl, benzyl, alkoxy, aryloxy, carbonyl, and carboxy, substituted or non-substituted.16. The composition of claim 15 , wherein said Lewis acid is in a molar concentration of at ...

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Номер записи: 81
11-03-2021 дата публикации

METHOD FOR PRODUCING METHIONINE

Номер: US20210070704A1
Автор: MIZUNO Takao, SHIMADA Noriyuki, Yamashita Daisuke
Принадлежит: Sumitomo Chemical Company, Limited

An object of the present invention to provide a method for producing methionine with consideration given to the environment. The production method of the present invention comprises a removal step of blowing an inert gas into a liquid containing 5-(2-methylmercaptoethyl)hydantoin and thereby diffusing ammonia remaining in the liquid to obtain an emission gas containing the ammonia, and a recovery step of bringing the emission gas into contact with a washing liquid to recover ammonia contained in the emission gas. 1. A method for producing methionine , comprising:reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, or a compound obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, with carbon dioxide and ammonia to obtain a liquid containing 5-(2-methylmercaptoethyl)hydantoin;introducing an inert gas into the liquid containing the 5-(2-methylmercaptoethyl)hydantoin and thereby diffusing ammonia remaining in the liquid to obtain an emission gas containing the ammonia;hydrolyzing the 5-(2-methylmercaptoethyl)hydantoin to obtain a liquid containing a methionine salt;introducing carbon dioxide into the liquid containing the methionine salt to precipitate methionine;separating a methionine precipitate from the liquid containing the methionine salt into a methionine containing solid and a liquid; 'recovering ammonia contained in the emission gas, the recovering comprising contacting the emission gas with a washing liquid,', 'and'} the recovering comprises at least one of a first recovery treatment and a second recovery treatment,', 'the first recovery treatment applies ammonium carbonate water as the washing liquid to dissolve ammonia contained in the emission gas into the ammonium carbonate water, and', 'the second recovery treatment circulates and applies water as the washing liquid to dissolve ammonia contained in the emission gas into the water., 'wherein'}2. The method according to claim 1 , wherein the recovering comprises the first ...

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Номер записи: 82
12-03-2015 дата публикации

4-(3-BENZYLOXYPHENYLTHIO)-2-CHLORO-1-(3-NITROPROPYL)BENZENE CRYSTAL

Номер: US20150073178A1
Автор: SATO HIROYA, Tsubuki Takeshi
Принадлежит:

[Problem] For example, 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene (compound 1) is used as an intermediate for producing a 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride which has excellent immunosuppressive activity. This compound 1 is traditionally obtained only as an oil and thus handling and refining were difficult. 1. A crystal of 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene , wherein , in powder X-ray diffraction using CuKα radiation with 2θ representing a diffraction angle , a powder X-ray diffraction image including the following 2θ peaks is observed: 2θ: 9.7 , 12.9 , 16.4 , 16.8 , 17.6 , 19.5 , 21.7 , 22.6 , 22.9 , 23.3 , 24.5 , 24.8 , 26.0 , 26.4 , 27.2.2. A crystal of 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene , wherein a powder X-ray diffraction image substantially the same as an image in is obtained by powder X-ray diffraction using CuKα radiation with 2θ representing a diffraction angle.3. The crystal of 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene according to claim 1 , wherein a melting point of the crystal measured by a hot plate method is 46° C. to 49° C.4. The crystal of 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene according to claim 1 , wherein claim 1 , in thermogravimetric/differential thermal analysis (TG/DTA) of the crystal claim 1 , no reduction in weight is observed until 49° C. claim 1 , and a single endothermic peak is observed at around 50° C.5. A production method of the crystal according to claim 1 , the method including the step of mixing 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene with an alcohol.6. The production method of the crystal according to claim 5 , wherein the 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene is dissolved in a soluble solvent that can dissolve the compound to obtain a solution claim 5 , and the obtained solution of the 4-(3-benzyloxyphenylthio)-2-chloro-1-(3- ...

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Номер записи: 83
17-03-2016 дата публикации

Thiolation method for modifying carbon nanotubes

Номер: US20160075646A1
Автор: Hong CHUANG, Ming-Hua Hsu
Принадлежит: National Tsing Hua University NTHU

A thiolation method for modifying carbon nanotubes includes steps as follows. A carboxylation step is provided, wherein the carbon nanotubes are reacted with an oxidant for generating carboxyl groups on surfaces of the carbon nanotubes so as to form carboxylated carbon nanotubes. A hydroxylation step is provided, wherein the carboxyl groups are transformed into hydroxyl groups so as to transform the carboxylated carbon nanotubes into hydroxylated carbon nanotubes. A thiolation step is provided, wherein the hydroxylated carbon nanotubes, a sulfur source and a first acidic substance are mixed and then stirred so as to form a first mixture, the first mixture is added portion-wisely into an alkaline solution so as to form a second mixture, and the second mixture is acidified so as to form an acidified solution having a pH value ranging from 2 to 3, thus the hydroxylated carbon nanotubes are transformed into thiolated carbon nanotubes.

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Номер записи: 84
15-03-2018 дата публикации

Methods for Producing Thiol Compounds and Sulfide Compounds Using Diphenylamine or a Phenol Compound

Номер: US20180072663A1
Автор: LASSEN Kenneth M.
Принадлежит:

The present invention discloses processes for producing a thiol compound or a sulfide compound from an olefin compound. Diphenylamine or a phenol compound can be used to increase the rate of conversion of the olefin compound to the thiol compound or the sulfide compound. 1. A process for producing a thiol compound , the process comprising: a) an olefin compound;', {'sub': '2', 'b) HS;'}, 'c) diphenylamine and/or a phenol compound comprising BHT, carvacrol, 2,2′-ethylidene-bis(4,6-di-tert-butylphenol), pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate), or any combination thereof; and', 'd) a photoinitiator and/or a free radical initiator; and, 'i) contactingii) forming the thiol compound.2. The process of claim 1 , wherein a molar ratio of HS to carbon-carbon double bonds of the olefin compound is from about 2:1 to about 150:1.3. The process of claim 1 , wherein:an amount of diphenylamine and/or the phenol compound is in a range from about 0.1 wt. % to about 1 wt. %, based on the weight of the olefin compound; andan amount of the photoinitiator and/or the free radical initiator is in a range from about 0.05 wt. % to about 5 wt. %, based on the weight of the olefin compound.4. The process of claim 1 , wherein the thiol compound is formed in the presence of ultraviolet light.5. The process of claim 1 , wherein the olefin compound comprises ethylene claim 1 , propylene claim 1 , 1-butene claim 1 , 2-butene claim 1 , 3-methyl-1-butene claim 1 , isobutylene claim 1 , 1-pentene claim 1 , 2-pentene claim 1 , 3-methyl-1-pentene claim 1 , 4-methyl-l-pentene claim 1 , 1-hexene claim 1 , 2-hexene claim 1 , 3-ethyl-1-hexene claim 1 , 1-heptene claim 1 , 2-heptene claim 1 , 3-heptene claim 1 , 1-octene claim 1 , 1-decene claim 1 , 1-dodecene claim 1 , styrene claim 1 , cyclopentene claim 1 , cyclohexene claim 1 , cycloheptene claim 1 , cyclooctene claim 1 , or any combination thereof.6. The process of claim 1 , wherein the olefin compound comprises limonene ...

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Номер записи: 85
24-03-2022 дата публикации

PROCESS FOR THE PREPARATION OF METHIONINE

Номер: US20220089533A1
Автор: BILZ Juergen, Borgmann Cornelia, FISCHER Achim, GEIST Lucas, NORDSCHILD Anja, Renner Christian, REUS Christian, RONNEBURG Axel
Принадлежит: EVONIK OPERATIONS GMBH

The present invention relates to a process for the preparation of methionine comprising the step of contacting a solution or suspension comprising 2-amino-4-(methylthio)butanenitrile and/or 2-amino-4-(methylthio)butaneamide with water in the presence of a catalyst to give a methionine comprising mixture, wherein the catalyst comprises CeOcomprising particles, wherein the CeOcomprising particles comprise from 50 to 100 wt.-% of CeO, have a BET surface area of from 35 to 65 m/g measured according to DIN ISO 9277-5 (2003), a mean maximum Feret diameter xof from 10 to 40 nm and a mean minimum Feret diameter xof from 5 to 30 nm, both measured according to DIN ISO 9276-6 (2012). 1. A process for the preparation of methionine , comprising contacting a solution or suspension comprising 2-amino-4-(methylthio)butanenitrile and/or 2-amino-4-(methylthio)butaneamide with water in the presence of a catalyst to produce a mixture comprising methionine ,{'sub': '2', 'wherein the catalyst comprises particles comprising CeO,'}{'sub': '2', 'wherein the particles comprise from 50 to 100 wt.-% of CeO,'}{'sup': '2', 'wherein the particles have a BET surface area of from 35 to 65 m/g measured according to DIN ISO 9277-5 (2003), and'}{'sub': Fmax, mean', 'Fmin, mean, 'wherein the particles have a mean maximum Feret diameter xof from 10 to 40 nm and a mean minimum Feret diameter xof from 5 to 30 nm, both measured according to DIN ISO 9276-6 (2012).'}2. The process of claim 1 , wherein the catalyst comprises from 25 to 100 wt.-% of the CeO claim 1 , based on the total weight of the catalyst.3. The process of claim 1 , wherein the particles have a mean minimum Feret diameter xof from 9 to 25 nm.4. The process of claim 1 , wherein the particles have a mean maximum Feret diameter xof from 13 to 36 nm.5. The process of claim 1 , wherein the mean minimum Feret diameter xof the particles is always smaller than the mean maximum Feret diameter xof the particles.6. The process of claim 1 , wherein the ...

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Номер записи: 86
24-03-2022 дата публикации

SALT-FREE PRODUCTION OF METHIONINE FROM METHIONINE NITRILE

Номер: US20220089534A1
Автор: BILZ Jürgen, Borgmann Cornelia, GEIST Lucas, Jakob Harald, Körfer Martin, REUS Christian, ROST Daniel
Принадлежит: EVONIK OPERATIONS GMBH

The invention refers to the use of a particulate catalyst containing 60.0 to 99.5 wt. % ZrOstabilised with an oxide of the element Hf and at least one oxide of the element M, wherein M=Ce, Si, Ti, or Y, for the hydrolysis reaction of methionine amide to methionine, wherein the median particle size xof the particulate catalyst is in the range of from 0.8 to 9.0 mm, preferably of from 1.0 to 7.0 mm. The invention also refers to a process for preparing methionine comprising a step of contacting a solution or suspension comprising methionine amide and water with said particulate catalyst to provide a reaction mixture comprising methionine and/or its ammonium salt from which methionine can be isolated. 1. A method of catalyzing the hydrolysis reaction of methionine amide to methionine , the method comprising contacting a solution or suspension comprising methionine amide and water with a particulate catalyst to produce a reaction mixture comprising methionine ,wherein the particulate catalyst comprises:{'sub': '2', '#text': '60.0 to 99.5 wt. % ZrO;'}an oxide of the element Hf; andat least one oxide of the element M, wherein M=Ce, Si, Ti, or Y,{'sub': '2', '#text': 'wherein the ZrOis stabilized by the oxide of the element Hf and the at least one oxide of the element M, and'}{'sub': '50', '#text': 'wherein the median particle size xof the particulate catalyst is in the range of from 0.8 to 9.0 mm.'}2. The method of claim 1 , wherein the element M=Si claim 1 , Ti claim 1 , or Y.3. The method of claim 1 , wherein the particle size xof the particulate catalyst is in the range of from 0.5 to 8.0 mm.4. The method of claim 1 , wherein the particulate catalyst comprises 0.1 to 40 wt. % of oxides of the elements Hf claim 1 , Ce claim 1 , Si claim 1 , Ti claim 1 , and Y.5. The method of claim 1 , wherein the particulate catalyst comprises:{'sub': ['2', '2', '2', '2', '3', '2'], '#text': '0.5 to 3.0 wt. % HfOand at least one selected from the group consisting of 0.1 to 40 wt. % TiO, ...

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Номер записи: 87
05-03-2020 дата публикации

HYDROCARBON CONVERSION CATALYST SYSTEM

Номер: US20200070128A1
Автор: JANTHARASUK Amnart, JAREEWATCHARA Wuttithep, SURIYE Kongkiat
Принадлежит: SMH Co., Ltd

The present invention relates to a hydrocarbon conversion catalyst system comprising: a first composition comprising a dehydrogenation active metal on a solid support; and a second composition comprising a transition metal on an inorganic support and a hydrocarbon conversion process utilizing the hydrocarbon conversion catalyst system. 1. A hydrocarbon conversion catalyst system , comprising:a. a first composition comprising a dehydrogenation active metal on a solid support; andb. a second composition comprising a transition metal on an inorganic support.2. The hydrocarbon conversion catalyst system according to claim 1 , wherein the dehydrogenation active metal is selected from the group consisting of platinum claim 1 , palladium claim 1 , iridium claim 1 , chromium claim 1 , and mixtures thereof.3. The hydrocarbon conversion catalyst system according to claim 1 , wherein the dehydrogenation active metal is platinum.4. The hydrocarbon conversion catalyst system according to claim 1 , wherein the solid support is selected from aluminum oxide claim 1 , silicon dioxide claim 1 , zirconium dioxide claim 1 , titanium dioxide claim 1 , magnesium oxide claim 1 , calcium oxide claim 1 , and mixtures thereof.5. The hydrocarbon conversion catalyst system according to claim 4 , wherein the solid support is a mixed of at least two or more metal oxides selected from the group consisting of mixed magnesium-aluminum oxide claim 4 , mixed calcium-aluminum oxide claim 4 , and mixture thereof.6. The hydrocarbon conversion catalyst system according to claim 5 , wherein the mixed of at least two or more metal oxides is derived from a layered double hydroxide.7. The hydrocarbon conversion catalyst system according to claim 1 , wherein the first composition further comprises an additional active metal selected from the group consisting of potassium claim 1 , tin claim 1 , lanthanum claim 1 , indium claim 1 , yttrium claim 1 , ytterbium claim 1 , rhenium claim 1 , and mixtures thereof.8. ...

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Номер записи: 88
19-03-2015 дата публикации

CATALYST COMPOSITIONS AND APPLICATIONS THEREOF

Номер: US20150079334A1
Автор: DIFRANCESCO Chris E., Oh Raymond, TREFZGER Christian
Принадлежит: CORMETECH, INC.

In one aspect, structural catalyst bodies comprising one or more gradients of catalytic material are provided herein. In some embodiments, a structural catalyst body described herein comprises an inner partition wall having a first surface and a second surface opposite the first surface, the inner partition wall having a gradient of catalytic material along the width of the inner partition wall. 1. A structural catalyst body comprising:at least one inner partition wall comprising a gradient of a bulk first catalytic material along a width of the inner partition wall.2. The structural catalyst body of claim 1 , wherein the bulk first catalytic material of the gradient decreases in concentration at the periphery of the width of the inner partition wall.3. The structural catalyst body of claim 1 , wherein the bulk first catalytic material of the gradient increases in concentration along a central region of the width of the inner partition wall.4. The structural catalyst body of claim 1 , wherein the gradient of the bulk first catalytic material has a profile substantially symmetrical about a midpoint of the profile.5. The structural catalyst body of claim 3 , wherein the concentration of the bulk first catalytic material at a point in the central region of the width of the inner partition wall is at least 1.3 times greater than a concentration of the bulk first catalytic material at a peripheral point of the width of the first surface.6. The structural catalyst body of claim 3 , wherein the concentration of bulk first catalytic material at a point in the central region of the width of the inner partition wall is at least 2 times greater than a concentration of the bulk first catalytic material at a peripheral point of the width of the first surface.7. The structural catalyst body of further comprising a gradient of a bulk second catalytic material along a width of the inner partition wall.8. The structural catalyst body of claim 7 , wherein the bulk second catalytic ...

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Номер записи: 89
05-06-2014 дата публикации

METHOD OF PRODUCING METHIONINE

Номер: US20140155652A1
Автор: KOIZUMI Yoshiyuki, Nishida Junichi, YAMASHIRO Naoya
Принадлежит: Sumitomo Chemical Company, Limited

The invention provides the following method capable of producing methionine in a shorter time by making rapid progress of the hydrolysis of 5-(2-methylmercaptoethyl)hydantoin from an aqueous 5-(2-methylmercaptoethyl)hydantoin solution containing ammonia component. A method of producing methionine is the method comprising hydrolyzing 5-(2-methylmercaptoethyl)hydantoin in an aqueous 5-(2-methylmercaptoethyl)hydantoin solution containing ammonia component, wherein the hydrolysis is performed after the ammonia component is removed from the aqueous solution. 1. A method of producing methionine , the method comprising hydrolyzing 5-(2-methylmercaptoethyl)hydantoin in an aqueous 5-(2-methylmercaptoethyl)hydantoin solution containing ammonia component , wherein the hydrolysis is performed after the ammonia component is removed from the aqueous solution.2. The production method according to claim 1 , wherein the aqueous 5-(2-methylmercaptoethyl)hydantoin solution containing ammonia component is a reaction solution obtained after 3-methylmercaptopropionaldehydecyanhydrin is reacted with a carbonic acid component and an excess amount of an ammonia component in the presence of water.3. The production method according to claim 1 , wherein the ammonia component is removed by blowing inert gas into the aqueous 5-(2-methylmercaptoethyl)hydantoin solution containing ammonia component. 1. Field of the InventionThe present application is filed, claiming the Paris Convention priority based on Japanese Patent Application No. 2012-265054 (filed on Dec. 4, 2012), and the entire content of which is incorporated herein by reference.The present invention relates to a method of producing methionine.2. Description of the Related ArtMethionine is useful as feed additive. As a method for producing such a methionine, a method in which 5-(2-methylmercaptoethyl)hydantoin is heated in the presence of an alkali component in water to hydrolyze is well known (JP-A-2007-314507).5-(2-methylmercaptoethyl) ...

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Номер записи: 90
18-03-2021 дата публикации

Demethylation of Methyl Ester of Methionine and its Hydroxy Analog

Номер: US20210078945A1
Автор: SØLVHØJ Amanda Birgitte, TAARNING Esben
Принадлежит: Haldor Topsoe A/S

The following invention regards a process of demethylating a methyl ester of methionine or its hydroxy analog and producing methane thiol as a side-product. The methionine and its hydroxy analog are suitable as an animal feed additive and as a food additive. The methane thiol may be consumed in a hydrothiolation step such as in a step of preparing the methyl ester of methionine or its hydroxy analog from from methyl vinyl glycolate. 1. A process of producing a demethylation product of the formula (II):{'br': None, 'sup': '31', 'sub': 2', '2', '3, 'OCO—CHR—CH—CH—S—CH\u2003\u2003(II)'}{'sub': '2', 'wherein R is —OH or —NH,'} {'br': None, 'sub': 3', '2', '2', '3, 'CH—OCO—CHR—CH—CH—S—CH\u2003\u2003(I),'}, 'comprising a demethylation step of reacting a methyl ester of the formula (I)wherein R has the same meaning as above,with a hydrogen sulfide anion to obtain methane thiol and the demethylation product of the formula (II).2. The process according to claim 1 , comprising recovering the methane thiol formed in the demethylation step.3. A process according to claim 2 , wherein the methane thiol recovered is used in a hydrothiolation step.4. A process of producing a demethylation product of the formula (II):{'br': None, 'sup': '−', 'sub': 2', '2', '3, 'OCO—CHR—CH—CH—S—CH\u2003\u2003(II)'}{'sub': '2', 'wherein R is —OH or —NH,'}comprising: {'br': None, 'sub': 3', '2, 'b': '50', 'CH—OCO—CHR—CH CH\u2003\u2003(III),'}, 'a1) a hydrothiolation step of reacting a compound of the formula (Ill)wherein R has the same meaning as above, {'br': None, 'sub': 3', '2', '2', '3, 'CH—OCO—CHR—CH—CH—S—CH\u2003\u2003(I),'}, 'with methane thiol to obtain a methyl ester of the formula (I)wherein R has the same meaning as above, andb) a demethylation step of reacting the methyl ester of the formula (I) with a hydrogen sulfide anion to obtain methane thiol and the demethylation product of the formula (II).5. A process of producing a demethylation product of the formula (II):{'br': None, 'sup': ...

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Номер записи: 91
14-03-2019 дата публикации

ORGANOSULFUR COMPOUNDS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES

Номер: US20190076377A1
Автор: Ott David Michael
Принадлежит:

Divalent salts of S-allylmercapto-N-acetylcysteine and related compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia. 120-. (canceled)21. A method of decreasing protein-aldehyde adducts in a human diagnosed with Parkinson's Disease ,said method comprising:administering to the human an organosulfur composition comprising an effective amount of a mixed disulfide of a lipophilic mercaptan disulfide bonded to N-acetylcysteine, wherein the mixed disulfide is bonded as a two to one salt with a divalent cation; said lipophilic mercaptan selected from the group consisting of propyl mercaptan, propenyl mercaptan, and allyl mercaptan;wherein said lipophilic mercaptan reacts with an aldehyde within the lipid membranes of said human, said aldehyde being in the form of an aldehyde or in the form of a protein-aldehyde adduct, to produce a molecular conjugate of said lipophilic mercaptan and said aldehyde;thereby decreasing protein-aldehyde adducts in the human.221. The method of claim where said administration of said organosulfur composition produces a decrease in the amount of protein carbonyls within the frontal cortex region of the brain.231. The method of claim where said administration of said organosulfur composition produces a decrease in the amount of protein carbonyls within the substantia nigra region of the brain.241. The method of claim where said divalent cation is magnesium or calcium.251. The method of claim where said organosulfur composition is a drug.265. The method of claim where the disulfide bonded lipophilic mercaptan within said ...

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Номер записи: 92
14-03-2019 дата публикации

METHOD FOR PRODUCING METHIONINE AND/OR 2-HYDROXY-4-(METHYLTHIO) BUTANOIC ACID

Номер: US20190077750A1
Автор: IKEGUCHI Masayuki
Принадлежит: Sumitomo Chemical Company, Limited

An object of the invention is to provide a simple method for producing methionine and/or 2-hydroxy-4-(methylthio)butanoic acid at a high yield using 3-(methylthio)propionaldehyde as a raw material. An oxide catalyst containing cerium, 3-(methylthio)propionaldehyde, a compound containing cyanide ion, ammonia or a compound containing ammonium ion, and water are contacted with each other to produce methionine and/or 2-hydroxy-4-(methylthio)butanoic acid. 1. A method for producing methionine and/or 2-hydroxy-4-(methylthio)butanoic acid , comprising contacting an oxide catalyst containing cerium , 3-(methylthio)propionaldehyde , a compound containing cyanide ion , ammonia or a compound containing ammonium ion , and water with each other.2. The method according to claim 1 , wherein the oxide catalyst containing cerium is at least one oxide selected from cerium oxides and oxide solid solutions containing cerium.3. The method according to claim 1 , wherein the compound containing cyanide ion is hydrogen cyanide.4. The method according to claim 1 , wherein ammonia or the compound containing ammonium ion is at least one member selected from aqueous ammonia claim 1 , liquid ammonia claim 1 , and ammonia gas.5. The method according to claim 1 , wherein the reaction temperature is 40 to 110° C.6. The method according to claim 1 , wherein the oxide catalyst containing cerium claim 1 , 3-(methylthio)propionaldehyde claim 1 , hydrogen cyanide claim 1 , ammonia claim 1 , and water are contacted with each other in a single vessel.7. The method according to claim 1 , wherein the oxide catalyst containing cerium and 3-(methylthio)propionaldehyde are contacted with each other in the presence of the compound containing cyanide ion and ammonia or the compound containing ammonium ion.8. The method according to claim 1 , wherein claim 1 , after the oxide catalyst containing cerium claim 1 , the compound containing cyanide ion claim 1 , ammonia or the compound containing ammonium ion claim 1 ...

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Номер записи: 93
14-03-2019 дата публикации

PROCESS FOR PRODUCING (POLY)SULFIDE COMPOUND AND PROCESS FOR PRODUCING EPISULFIDE COMPOUND

Номер: US20190077751A1
Автор: KAWAGUCHI Masaru, Kuma Shigetoshi, Shimakawa Chitoshi, Tokunaga Koichi
Принадлежит: Mitsui Chemicals, Inc.

In a process for producing a (poly) sulfide compound represented by General Formula (2) of the present invention, thiol compounds represented by General Formula (1) are reacted with each other in the presence of a basic compound represented by General Formula (4) or General Formula (5) and sulfur. 2. The process for producing a (poly)sulfide compound according to claim 1 , wherein the thiol compounds are reacted at a pressure of 50 Torr to 600 Torr.3. The process for producing a (poly)sulfide compound according to claim 1 ,{'sub': 1', '2, 'wherein the halogen atom as Xor Xis a chlorine atom.'}5. The process for producing a (poly)sulfide compound according to claim 1 ,wherein the compound represented by General Formula (4) is sodium hydrogen sulfide. The present invention relates to a process for producing a (poly)sulfide compound having a bishalohydrin group and a process for producing an episulfide compound having a (poly)sulfide bond.Compared with inorganic lenses, plastic lenses have a low weight, are not easily cracked, and can be dyed, and thus, recently, have rapidly become widespread in optical elements such as eyeglass lenses and camera lenses.For resins for plastic lenses, there has been a demand for additional improvement in performance, and there has been a demand for an increase in the refractive index, an increase in the Abbe number, a decrease in the specific weight, an improvement of the heat resistance, and the like. Thus far, a variety of resin materials for lenses have been developed and put into use.Among them, optical materials comprised of sulfide-based resins have a high refractive index and a high Abbe number and are being studied as ultrahigh refractive index materials having a refractive index of higher than 1.6. Sulfide-based resins are obtained by polymerizing a polymerizable composition including an episulfide compound.For molded product comprised of a sulfide-based resin, for the purpose of increasing the refractive index, a method for ...

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Номер записи: 94
22-03-2018 дата публикации

Mixed Decyl Mercaptans Compositions and Methods of Making Same

Номер: US20180079718A1
Автор: Byers Jim D., KREIDER Jason L., Matson Michael S.
Принадлежит:

Compositions comprising branched Cmercaptans selected from the group consisting of 5-methyl-1-mercapto-nonane, 3-propyl-1-mercapto-heptane, 4-ethyl-1-mercapto-octane, 2-butyl-1-mercapto-hexane, 5-methyl-2-mercapto-nonane, 3-propyl-2-mercapto-heptane, 4-ethyl-2-mercapto-octane, 5-methyl-5-mercapto-nonane, and combinations thereof. Compositions comprising C mercaptans, wherein the C mercaptans are characterized by structure R—SH, wherein Ris an alkyl group derived from one or more C monoolefins, and wherein the one or more C monoolefins comprise Cinternal monoolefins, Cinternal monoolefins, Cinternal monoolefins, Cinternal monoolefins, 1-tetradecene, 1-hexadecene, or combinations thereof. Compositions comprising branched C mercaptans, wherein the branched C mercaptans are characterized by structure R—SH, wherein Ris an alkyl group derived from one or more branched Cto Cmonoolefins. 1. A composition comprising C mercaptans , wherein at least about 50 wt. % of the C mercaptans are branched Cto Cmercaptans characterized by the general formula R—SH , wherein Ris a branched alkyl group; and wherein Rhas from 10 to 30 carbon atoms.3. The composition of claim 1 , wherein Ris a Cto Calkyl group.4. A composition comprising C sulfides claim 1 , wherein at least about 50 wt. % of the C sulfides are branched Cto Csulfides represented by structure R—S—R claim 1 , wherein Rand Rare each independently a functional group derived from an olefin claim 1 , and wherein the olefin comprises a branched Cto Cmonoolefin.6. The composition of claim 5 , wherein Ris a Cto Calkyl group.7. The composition of claim 4 , wherein the olefin further comprises from about 0.1 mol % to about 26 mol % linear Cto Cmonoolefins.8. The composition of claim 4 , wherein the olefin further comprises from about 0.1 mol % to about 5 mol % Cmonoolefins claim 4 , the Cmonoolefins comprising at least about 95 mol % 1-octene.9. The composition of claim 4 , wherein the olefin comprises i) at least about 70 wt. % ...

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Номер записи: 95
24-03-2016 дата публикации

METHOD FOR PRODUCING a-SUBSTITUTED CYSTEINE OR SALT THEREOF OR SYNTHETIC INTERMEDIATE OF a-SUBSTITUTED CYSTEINE

Номер: US20160083341A1
Автор: Asuma Yuuki, Kawabata Hiroshi, MAEDA Tomoko, Miyake Ryoma, Saito Yasuyo, Uehara Hisatoshi
Принадлежит: API Corporation

According to the present invention, it becomes possible to perform a process for converting into an α-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance. In the production of an α-substituted-D-cysteine or a salt thereof, it becomes possible to perform a process for converting the compound represented by general formula (2) into a compound represented by general formula (3S) in one step by allowing an enzyme or the like to act on the compound represented by general formula (2). 4. The method for producing a compound represented by the General Formula (3S) according to claim 3 , wherein said enzyme is(A) a protein comprising the amino acid sequence of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, or 18;(B) a protein having an identity of not less than 35% to the amino acid sequence of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, or 18, and having an activity to hydrolyze said compound represented by the General Formula (2) for conversion into said compound represented by the General Formula (3S) having the (S)-configuration; or(C) a protein comprising the amino acid sequence of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, or 18 in which one or several amino acids are deleted, substituted, and/or added, and having an ...

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Номер записи: 96
12-03-2020 дата публикации

METHIONINE PRODUCTION METHOD AND PRODUCTION EQUIPMENT

Номер: US20200079730A1
Автор: KATAGAMI Ryousuke, KOIZUMI Yoshiyuki, MORIKAWA Masayuki, Omoto Norihito, SATOH YOSHITAKA, YAMASHIRO Naoya
Принадлежит: Sumitomo Chemical Company, Limited

The present invention provides a method for producing methionine characterized by comprising a step of hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of an alkali compound to obtain a reaction solution containing an alkali salt of methionine, a step of precipitating methionine by introducing carbon dioxide into the reaction solution to obtain a first slurry containing the methionine, a step of allowing the first slurry to flow into a pressurized filter and obtaining the solid methionine and mother liquor from the first slurry, and a step of recovering carbon dioxide from the mother liquor. By the present production method, the carbon dioxide introduced in the crystallization step is suppressed from being released from the mother liquor, and the carbon dioxide can be recovered. 1. A method for producing methionine which comprises the following steps (1) to (4):(1) a reaction step: a step of hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of an alkali compound to obtain a reaction solution containing an alkali salt of methionine,(2) a crystallization step: a step of precipitating methionine by introducing carbon dioxide into the reaction solution to obtain a first slurry containing the methionine,(3) a solid-liquid separation step: a step of allowing the first slurry to flow into a pressurized filter and obtaining the solid methionine and mother liquor from the first slurry, and(4) a carbon dioxide recovery step: a step of recovering carbon dioxide from the mother liquor.2. The method for producing methionine according to claim 1 , wherein the solid-liquid separation step comprises a first solid-liquid separation step and a second solid-liquid separation step claim 1 , and the first solid-liquid separation step is a step of allowing the first slurry to flow into a pressurized filter and obtaining the solid methionine and the mother liquor from the first slurry claim 1 , and the second solid-liquid separation step ...

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Номер записи: 97
25-03-2021 дата публикации

METHOD FOR MANUFACTURING METHIONINE

Номер: US20210087139A1
Автор: KOIZUMI Yoshiyuki, MIZUNO Takao, Yamashita Daisuke
Принадлежит: Sumitomo Chemical Company, Limited

An object of the present invention is to provide a method for manufacturing methionine capable of achieving an improvement in ammonia removal efficiency. The manufacturing method of the present invention comprises a removal step of supplying a liquid containing a methionine salt, which is obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, or a compound obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, with carbon dioxide and ammonia to obtain a liquid containing 5-(2-methylmercaptoethyl)hydantoin and then hydrolyzing the 5-(2-methylmercaptoethyl)hydantoin, to a diffusion tower from an upper portion thereof while supplying a stripping gas to the diffusion tower from a lower portion thereof to remove ammonia contained in the liquid through stripping, and the stripping gas contains a process gas generated in a process of manufacturing methionine. 1. A method for manufacturing methionine comprisinga hydantoin step of reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, or a compound obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, with carbon dioxide and ammonia to obtain a liquid containing 5-(2-methylmercaptoethyl)hydantoin,a hydrolysis step of hydrolyzing the 5-(2-methylmercaptoethyl)hydantoin to obtain a liquid containing a methionine salt,a crystallization step of introducing carbon dioxide into the liquid containing a methionine salt to precipitate methionine, anda separation step of performing solid-liquid separation of a methionine slurry obtained in the crystallization step into a cake of the methionine and a mother liquor,the method comprising:a removal step of supplying the liquid containing a methionine salt obtained in the hydrolysis step to a diffusion tower from an upper portion thereof and supplying a stripping gas to the diffusion tower from a lower portion thereof to remove ammonia contained in the liquid through stripping, whereinthe stripping gas contains a process ...

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Номер записи: 98
21-03-2019 дата публикации

Method for Preparation of N-Acetyl Cysteine Amide and Derivatives Thereof

Номер: US20190084926A1
Автор: Bolger Josh, JOHNSON DOUG, Rubenstein Anja, Tucker Rodney, Wall G. Michael
Принадлежит:

The present invention includes methods for making and isolating N-acetylcysteine amide, intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide; and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol. 1. A process for making N-acetylcysteine amide comprising:contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride;combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester;mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide; andseparating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.2. The process of claim 1 , wherein the alcohol is an organic alcohol selected from an alkyl alcohol claim 1 , methanol claim 1 , ethanol claim 1 , propanol claim 1 , iso-propanol or butanol.3. The process of claim 1 , wherein the step of contacting L-cysteine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride is conducted at −10 to 10° C. and then heated to reflux at 65 to 70° C. to completion.4. The process of claim 1 , wherein the chlorinating agent is thionyl chloride.5. The process of claim 1 , further comprising a solvent exchange between the contacting and the combining steps.6. The process of claim 1 , wherein ...

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Номер записи: 99
19-06-2014 дата публикации

New Process

Номер: US20140171502A1
Автор: Mair Hans-Juergen, Reents Reinhard, Scalone Michelangelo, Wang Shaoning, Zogg Andreas
Принадлежит: Hoffmann-La Roche Inc.

The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is useful as a pharmaceutically active compound. 5. The process according to claim 1 , wherein Ris (2-Ethyl-butyl)-cyclohexyl.6. The process according to claim 1 , wherein X claim 1 , Xand Xare each independently hydrogen or a (C-C)alkyl.7. The process according to claim 1 , wherein X claim 1 , X and X are each independently hydrogen or a (C-C)alkyl.13. The process according to wherein Ris isopropyl and the acylating agent is isobutyric anhydride or isobutyryl halide.14. The process according to wherein the acylating agent is isobutyric anhydride.15. The process according to claim 14 , wherein 2.0 to 4.0 equivalents of isobutyric anhydride with respect to the disulfide of formula (II) is used.16. The process according to in the presence of a solvent or a mixture of two or more solvents.17. The process according to claim 16 , wherein the solvent is an organic solvent.18. The process according to claim 16 , wherein the solvent is an ether like solvent claim 16 , ester like solvent claim 16 , aliphatic hydrocarbon solvent claim 16 , saturated alicyclic hydrocarbon solvent claim 16 , aromatic solvent or a mixture thereof.19. The process according to claim 16 , wherein the solvent is an aliphatic hydrocarbon solvent claim 16 , saturated alicyclic hydrocarbon solvent claim 16 , or aromatic solvent.20. The process according to wherein the acylating agent is an anhydride derivative which can act as a solvent or co-solvent with a molar ratio anhydride/amidodisulfide of 2 to 19.22. The process according to claim 21 , wherein the His added at a pressure of at least 0.1 bar.23. The process according to claim 1 , wherein the reaction is carried out at temperature up to 150° C.24. The process according to claim 1 , wherein the heterogeneous transition metal hydrogenation catalyst is a Raney catalyst claim 1 , Pd/C claim 1 , Pd(OH)/C ...

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Номер записи: 100