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Применить Всего найдено 21924. Отображено 100.
16-12-1998 дата публикации

УСТРОЙСТВО ДЛЯ МЕХАНИЧЕСКОЙ ПОЛИРОВКИ ОБРАЗЦОВ КОСТИ

Номер: RU0000008609U1
Автор: Докторов Александр Альбертович, Матвейчук Игорь Васильевич, Ярыгин Николай Владимирович
Принадлежит: Докторов Александр Альбертович, Матвейчук Игорь Васильевич, Ярыгин Николай Владимирович

Устройство для механической полировки образцов кости, содержащее держатель образца и абразивный элемент, отличающееся тем, что оно снабжено ванной с жидким азотом, в которую помещен абразивный элемент, выполненный в виде металлической пластины с напыленным на ее поверхность слоем окиси цинка или алюминия, при этом держатель образца выполнен в виде предназначенной для установки в патроне станка насадки с пробковым теплоизолятором, а для крепления образца к теплоизолятору использован лед. (19) RU (11) (13) 8 609 U1 (51) МПК A61L 31/00 (1995.01) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К СВИДЕТЕЛЬСТВУ (21), (22) Заявка: 97111998/20, 21.07.1997 (46) Опубликовано: 16.12.1998 (71) Заявитель(и): Ярыгин Николай Владимирович, Докторов Александр Альбертович, Матвейчук Игорь Васильевич 8 6 0 9 R U (57) Формула полезной модели Устройство для механической полировки образцов кости, содержащее держатель образца и абразивный элемент, отличающееся тем, что оно снабжено ванной с жидким азотом, в которую помещен абразивный элемент, выполненный в виде металлической пластины с напыленным на ее поверхность слоем окиси цинка или алюминия, при этом держатель образца выполнен в виде предназначенной для установки в патроне станка насадки с пробковым теплоизолятором, а для крепления образца к теплоизолятору использован лед. Ñòðàíèöà: 1 U 1 U 1 (54) УСТРОЙСТВО ДЛЯ МЕХАНИЧЕСКОЙ ПОЛИРОВКИ ОБРАЗЦОВ КОСТИ 8 6 0 9 (73) Патентообладатель(и): Ярыгин Николай Владимирович, Докторов Александр Альбертович, Матвейчук Игорь Васильевич R U (72) Автор(ы): Ярыгин Николай Владимирович, Докторов Александр Альбертович, Матвейчук Игорь Васильевич RU 8 609 U1 RU 8 609 U1 RU 8 609 U1

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Номер записи: 1
27-11-2008 дата публикации

ИГЛА ДЛЯ ВНУТРИТКАНЕВОЙ ИНЪЕКЦИИ

Номер: RU0000078428U1
Автор: Макаров Валерий Николаевич, Хитров Юрий Александрович
Принадлежит: Макаров Валерий Николаевич, Хитров Юрий Александрович

Игла для внутритканевой инъекции, содержащая головку и трубку с боковыми отверстиями, отличающаяся тем, что на поверхность трубки нанесен пористый слой гидрофильного биосовместимого полимера, закрывающий также отверстия. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 78 428 (13) U1 (51) МПК A61M 5/32 (2006.01) A61L 29/08 (2006.01) A61L 31/08 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2006145841/22 , 25.12.2006 (24) Дата начала отсчета срока действия патента: 25.12.2006 (45) Опубликовано: 27.11.2008 (73) Патентообладатель(и): Хитров Юрий Александрович (RU), Макаров Валерий Николаевич (RU) Формула полезной модели Игла для внутритканевой инъекции, содержащая головку и трубку с боковыми отверстиями, отличающаяся тем, что на поверхность трубки нанесен пористый слой гидрофильного биосовместимого полимера, закрывающий также отверстия. 7 8 4 2 8 (54) ИГЛА ДЛЯ ВНУТРИТКАНЕВОЙ ИНЪЕКЦИИ R U Адрес для переписки: 117342, Москва, ул. Введенского, 27, корп.2, кв.157, В.Н. Макарову (72) Автор(ы): Хитров Юрий Александрович (RU), Макаров Валерий Николаевич (RU) R U 7 8 4 2 8 U 1 U 1 Ñòðàíèöà: 1 RU 5 10 15 20 25 30 35 40 45 50 78 428 U1 Настоящее изобретение относится к области медицины и ветеринарии, преимущественно к хирургии, и может быть использовано для разрушения патологически измененных тканей тела человека и животных. Иглы для внутритканевых инъекций широко используются для подкожного и внутримышечного введения лекарственных веществ. Инъекции в более глубоко расположенные ткани до недавних пор использовались сравнительно редко. Однако, в последнее время были разработаны малоинвазивные методы разрушения небольших опухолей и метастазов печени, почек и других органов путем прямых инъекций в них биоцидных препаратов и нагретых солевых растворов с помощью достаточно длинных инъекционных игл, вводимых под контролем ультразвукового сканера, (G.Garcea, Т.D.Lloyd, С.Aylott, G.Maddem and D.P. ...

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Номер записи: 2
10-08-2012 дата публикации

ПОЛИМЕРНОЕ ПОКРЫТИЕ ДЛЯ ЛАПАРОСТОМИИ ПРИ РАСПРОСТРАНЕННОМ ПЕРИТОНИТЕ

Номер: RU0000118864U1
Автор: Карпова Ирина Юрьевна, Паршиков Владимир Вячеславович, Паршиков Вячеслав Владимирович, Успенский Игорь Вадимович
Принадлежит: Государственное бюджетное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО НижГМА Минздравсоцразвития России)

Полимерная пленка для лапаростомии при распространенном перитоните у новорожденных и детей младшего грудного возраста в виде эластичной, прозрачной пленки прямоугольной формы с закругленными краями и сквозными отверстиями, обе поверхности которой выполнены гладкими, отличающаяся тем, что гладкие поверхности пленки выполнены со степенью шероховатости не более 8 нм, расстояние между центрами соседних отверстий составляет от 5 до 10 мм, при этом при длине стороны 80 мм диаметр отверстий равен 3 мм, при длине стороны 120 мм диаметр отверстий равен 4 мм. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61L 31/04 (13) 118 864 U1 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2011144971/15, 08.11.2011 (24) Дата начала отсчета срока действия патента: 08.11.2011 (45) Опубликовано: 10.08.2012 Бюл. № 22 1 1 8 8 6 4 Адрес для переписки: 603005, г.Нижний Новгород, ул. Алексеевская, 1, Учебно-лабораторный корпус ГБОУ ВПО НижГМА Росздрава, патентно-лицензионный отдел, Е.К. Павловой (73) Патентообладатель(и): Государственное бюджетное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО НижГМА Минздравсоцразвития России) (RU) R U Приоритет(ы): (22) Дата подачи заявки: 08.11.2011 (72) Автор(ы): Карпова Ирина Юрьевна (RU), Паршиков Вячеслав Владимирович (RU), Паршиков Владимир Вячеславович (RU), Успенский Игорь Вадимович (RU) 1 1 8 8 6 4 R U Формула полезной модели Полимерная пленка для лапаростомии при распространенном перитоните у новорожденных и детей младшего грудного возраста в виде эластичной, прозрачной пленки прямоугольной формы с закругленными краями и сквозными отверстиями, обе поверхности которой выполнены гладкими, отличающаяся тем, что гладкие поверхности пленки выполнены со степенью шероховатости не более 8 нм, расстояние между центрами соседних отверстий ...

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Номер записи: 3
05-01-2012 дата публикации

Methods to improve adhesion of polymer coatings over stents

Номер: US20120004721A1
Автор: Daniel A. Castro, Stephen D. Pacetti, Yunbing Wang
Принадлежит: Individual

Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.

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Номер записи: 4
10-07-2016 дата публикации

СТЕНТ ДЛЯ ЛЕЧЕНИЯ ПОРАЖЕНИЙ БЕДРЕННО-ПОДКОЛЕННЫХ АРТЕРИЙ

Номер: RU0000163082U1
Автор: Генералов Михаил Игоревич, Гранов Дмитрий Анатольевич, Жеребцов Федор Константинович, Иванов Александр Сергеевич, Майстренко Дмитрий Николаевич, Таразов Павел Гадельгараевич
Принадлежит: ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ / ФГБУ "РНЦРХТ" Минздрава России

Стент для лечения поражений бедренно-подколенных артерий, состоящий из ячеистой трубки, изготовленной методом лазерной резки, имеющей металлическое покрытие из хром-кобальта, отличающийся тем, что его дистальный конец выполнен в виде "рыбьего рта", преобразующий кровоток по выходу из стента в ламинарноспиральный. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 163 082 U1 (51) МПК A61F 2/82 (2013.01) A61F 2/91 (2013.01) A61L 31/10 (2006.01) A61L 27/30 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2015132730/14, 05.08.2015 (24) Дата начала отсчета срока действия патента: 05.08.2015 (45) Опубликовано: 10.07.2016 U 1 R U (54) СТЕНТ ДЛЯ ЛЕЧЕНИЯ ПОРАЖЕНИЙ БЕДРЕННО-ПОДКОЛЕННЫХ АРТЕРИЙ (57) Реферат: Полезная модель относится к медицине, точнее обеспечивается ламинарный винтообразный к сосудистой хирургии, и может найти применение поток крови и дистальный конец стента позволяет при операциях прямой реваскуляризации максимально адаптировать диаметр стента к конечностей. Стент, состоящий из ячеистой уменьшаемому диаметру просвета трубки, изготовленной методом лазерной резки, периферической артерии нижней конечности. имеет измененную форму дистального конца в Стент разоработан в отделении сердечновиде «рыбьего рта», который преобразует сосудистой хирургии РНЦРХТ и прошел кровоток по выходу из стента в стендовые испытания и готов к проведению ламинарноспиральный. Преимуществами данного оперативных вмешательств на бедренных артерий стента является то, что при его использовании у больных. Стр.: 1 U 1 1 6 3 0 8 2 (73) Патентообладатель(и): ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ / ФГБУ "РНЦРХТ" Минздрава России (RU) 1 6 3 0 8 2 Адрес для переписки: 197758, Санкт-Петербург, п. Песочный, ул. Ленинградская, 70, ФГБУ "РНЦРХТ" Минздрава России, Ишинову Илье Юрьевичу R U Приоритет(ы): (22) Дата подачи ...

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Номер записи: 5
10-10-2016 дата публикации

ИРИДОКАПСУЛЯРНАЯ КЛИПСА

Номер: RU0000165158U1
Автор: Иошин Игорь Эдуардович, Латыпов Ильяс Амирович, Мурашев Александр Олегович
Принадлежит: Иошин Игорь Эдуардович, Латыпов Ильяс Амирович, Мурашев Александр Олегович

Иридокапсулярная клипса, характеризующаяся тем, что она выполнена из моноволоконной полипропиленовой нити, один конец клипсы имеет форму восьмерки с диаметром колец по 0,5-2,0 мм или овала с большим диаметром 0,5-4,5 мм и является упорным, а второй конец имеет два колена, большее колено длиной 2-5 мм закруглено в плоскости, перпендикулярной плоскости упорного конца, а малое колено длиной 0,5-2,5 мм заканчивается загнутым крючком длиной 0,1-1 мм. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 165 158 U1 (51) МПК A61L 31/04 (2006.01) A61F 9/007 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2016109816/15, 18.03.2016 (24) Дата начала отсчета срока действия патента: 18.03.2016 (73) Патентообладатель(и): Иошин Игорь Эдуардович (RU), Мурашев Александр Олегович (RU), Латыпов Ильяс Амирович (RU) (45) Опубликовано: 10.10.2016 U 1 1 6 5 1 5 8 R U Стр.: 1 закруглено в плоскости, перпендикулярной плоскости упорного конца, а малое колено длиной 0,5-2,5 мм заканчивается загнутым крючком длиной 0,1-1 мм. Использование клипсы обеспечивает фиксацию смещенной ИОЛ с наименьшей степенью травматизации тканей, а, следовательно, соответствующим снижением вероятности развития воспалительных осложнений. U 1 (54) ИРИДОКАПСУЛЯРНАЯ КЛИПСА (57) Реферат: Полезная модель в виде иридокапсулярной клипсы относится к медицине, а именно, к офтальмохирургии и может быть использована в хирургии катаракты. Иридокапсулярная клипса выполнена из моноволоконной полипропиленовой нити. Один конец клипсы имеет форму восьмерки с диаметром колец по 0,5-2,0 мм или овала с большим диаметром 0,54,5 мм и является упорным. Второй конец клипсы имеет два колена, большее колено длиной 2-5 мм 1 6 5 1 5 8 Адрес для переписки: 150049, г. Ярославль, ул. Ухтомского, 15-49, Мурашеву А.О. R U Приоритет(ы): (22) Дата подачи заявки: 18.03.2016 (72) Автор(ы): Иошин Игорь Эдуардович (RU), Мурашев Александр Олегович (RU), Латыпов Ильяс Амирович (RU) RU 5 10 15 20 25 30 ...

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Номер записи: 6
19-04-2017 дата публикации

Аппарат внешней фиксации

Номер: RU0000170273U1
Автор: Алиев Эльчин Ильяс Оглы, Ахтямов Ильдар Фуатович, Гатина Эльмира Биктимировна, Шакирова Фаина Владимировна, Ширванова Азалина Анисовна
Принадлежит: Ахтямов Ильдар Фуатович

Полезная модель относится к медицине, конкретно - к травматологии и ортопедии. Используется для лечения переломов и деформаций костей. Сущность полезной модели заключается в совокупности существенных признаков, достаточной для достижения искомого технического результата, состоящего в профилактике развития аллергической реакции на фиксирующие кость спицы и костные винты при использовании аппарата внешней фиксации. Сущность заявляемого устройства состоит в том, что аппарат внешней фиксации имеет кольца, штанги и фиксаторы, в которых крепятся спицы и костные винты, имеющие покрытие из смеси нитридов титана и гафния. Это покрытие является «оболочкой» спицы или костного винта, ограждающей кость пациента от воздействия металла (из которого изготовлена спица). Оно имеет биоинертные свойства и предупреждает развитие аллергии и реакции отторжения. 3 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК A61B 17/60 A61B 17/62 A61B 17/64 A61B 17/66 A61L 31/12 A61L 27/04 (11) (13) 170 273 U1 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21)(22) Заявка: 2016114588, 14.04.2016 (24) Дата начала отсчета срока действия патента: 14.04.2016 Дата регистрации: (73) Патентообладатель(и): Ахтямов Ильдар Фуатович (RU) (45) Опубликовано: 19.04.2017 Бюл. № 11 (56) Список документов, цитированных в отчете о поиске: RU 135251 U1, 10.12.2013. RU 1 7 0 2 7 3 R U (54) Аппарат внешней фиксации (57) Реферат: Полезная модель относится к медицине, конкретно - к травматологии и ортопедии. Используется для лечения переломов и деформаций костей. Сущность полезной модели заключается в совокупности существенных признаков, достаточной для достижения искомого технического результата, состоящего в профилактике развития аллергической реакции на фиксирующие кость спицы и костные винты при использовании аппарата внешней фиксации. Стр.: 1 145527 U1, 20.09.2014. RU 2011131611A, 20.11.2013. RU 80743 U1, 27.02.2009. ...

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Номер записи: 7
17-05-2017 дата публикации

КАРКАС СТЕНТА ИЗ БИОДЕЗИНТЕГРИРУЕМОГО МАТЕРИАЛА

Номер: RU0000171036U1
Автор: Глущенко Леонид Витальевич, Лейбель Олег Игоревич, Седуш Никита Геннадьевич, Шарафеев Айдар Зайтунович, Щепочкин Владислав Александрович
Принадлежит: Общество с ограниченной ответственностью "ИнТехноБиоМед" (ООО "ИнТехноБиоМед")

Полезная модель относится к медицине, а именно к стентам из биодезинтегрируемого материала и может быть использована в эндоваскулярной хирургии, в частности для профилактики тромбоэмболии легочных артерий, при лечении атеросклероза коронарных и периферических артерий. Каркас стента из биодизентегрируемого материала, имеющий, по существу, трубчатую форму, образованную совокупностью зигзагоподобных страт, соединенных между собой в области соответствующих Z-изгибов и сформированных из материала с памятью формы, представляющего собой комбинацию биосовместимых биоабсорбируемых мономерных компонентов, объединенных вместе в сополимере, включающем как аморфный компонент с температурой стеклования ниже температуры тела человека, так одновременно и кристаллизующийся компонент с температурой плавления выше температуры тела человека. 1 з.п. ф-лы, 4 фиг. И 1 171036 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ ВУ” 174 036” 44 ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ИЗВЕЩЕНИЯ К ПАТЕНТУ НА ПОЛЕЗНУЮ МОДЕЛЬ ММ9К Досрочное прекращение действия патента из-за неуплаты в установленный срок пошлины за поддержание патента в силе Дата прекращения действия патента: 20.02.2020 Дата внесения записи в Государственный реестр: 15.10.2020 Дата публикации и номер бюллетеня: 15.10.2020 Бюл. №29 Стр.: 1 па ЭУЕОбЕАЬ ЕП

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Номер записи: 8
15-03-2018 дата публикации

Спиценатягиватель к компрессионно-дистракционному аппарату

Номер: RU0000177921U1
Автор: Буравлева Лариса Валентивна, Ероклинцев Владимир Николаевич, Ероклинцев Дмитрий Владимирович, Киреев Сергей Иванович, Лукьянова Виктория Олеговна, Пичхидзе Сергей Яковлевич
Принадлежит: Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.)

Полезная модель относится к медицинской технике, а именно к травматологии и ортопедии, и может быть использована в качестве устройства для натяжения спиц в компрессионно-дистракционных аппаратах при остеосинтезе. Техническим результатом, достигаемым при использовании заявляемой полезной модели, является обеспечение высокой надежности крепления спицы. Спиценатягиватель к компрессионно-дистракционному аппарату, содержащий верхнюю и нижнюю ручки, переходящие в губки, упорное колено, возвратную скобу, паз для укладки спицы, согласно заявляемому техническому решению, содержит фиксирующий зуб, выполненный на верхней ручке спиценатягивателя в виде прямоугольного выступа с возможностью при перемещении верхней и нижней губок навстречу друг другу в сторону осуществлять прогиб спицы, кроме того, поверхность стального спиценатягивателя выполняют азотированной, при этом прямоугольный выступ фиксирующего зуба выполнен с возможностью осуществления прогиба спицы на 2 диаметра спицы до достижения радиуса кривизны спицы R3,5 мм. 1 з.п. ф-лы, 6 фиг. И 1 177921 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ 7 ВУ” 177 9241” 414 ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ИЗВЕЩЕНИЯ К ПАТЕНТУ НА ПОЛЕЗНУЮ МОДЕЛЬ ММ9К Досрочное прекращение действия патента из-за неуплаты в установленный срок пошлины за поддержание патента в силе Дата прекращения действия патента: 06.06.2019 Дата внесения записи в Государственный реестр: 20.03.2020 Дата публикации и номер бюллетеня: 20.03.2020 Бюл. №8 Стр.: 1 па ебу ЕП

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Номер записи: 9
02-02-2012 дата публикации

Before-use mixing container

Номер: US20120024862A1
Автор: Tadashi Otsuka, Takashi Fujimoto
Принадлежит: Hanshin Kasei Kogyo Co Ltd, Senju Pharmaceutical Co Ltd

The present invention provides a before-use mixing container in which it is possible to perform a mixing operation for two types of medicinal solutions in its container independently of an uncovering operation for a cap or the like. The before-use mixing container including a movable body 1 which has a tube section 11 , a ceiled cylindrical inner tube 13 which is consecutively installed upright on an inner surface of the tube section, that partitions the tube section into two upper and lower chambers, and a first opening portion 13 b drilled in a ceiling plane 13 a of the inner tube, and in which a first medicinal solution A is contained in the lower chamber, an adapter 3 which has a fit-in tube section 31 which is tightly fit into the upper chamber of the movable body to be assembled so as to be rotatable with respect to the movable body, a partition wall surface 35 which is provided on an inner surface of the fit-in tube section, and is tightly attached to the ceiling plane of the inner tube of the movable body, and a second opening portion 35 a which is drilled in the partition wall surface so as not to overlap the first opening portion, and a container main body 4 which has a lower mouth tube section 42 tightly fit into the upper chamber of the adapter, to be assembled so as not to be rotatable with respect to the adapter, and in which a second medicinal solution B is contained, in the before-use mixing container, when the movable body is relatively rotated with respect to the container main body, the first opening portion and the second opening portion are overlapped.

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Номер записи: 10
09-02-2012 дата публикации

Condom with Warmth Imparting Lubricant

Номер: US20120031409A1
Автор: April Ensinger, Dennis Blum, James Daniels, Jr., Michael J. Harrison, R. Christian Millar, Robin Luyber
Принадлежит: Church and Dwight Co Inc

A condom together with a lubrication composition, the lubricating composition containing a minimal amount of free water, and comprising one or more glycols, such that the glycols in the lubricant release heat and warmth when contact with compositions containing free water.

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Номер записи: 11
09-02-2012 дата публикации

Polylactide-coated implant composed of a biocorrodible magnesium alloy

Номер: US20120035716A1
Автор: Alexander Borck, Bjoern Klocke
Принадлежит: BIOTRONIK AG

Some invention embodiments relate to an implant having a base body composed of a biocorrodible magnesium alloy and a polylactide coating. The implant is characterized in that the coating contains seed crystals and/or lipophilic substances as additives.

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Номер записи: 12
09-02-2012 дата публикации

Intravitreous self adaptive stent

Номер: US20120035738A1
Автор: Rongping Dai
Принадлежит: EMPIRE TECHNOLOGY DEVELOPMENT LLC

Disclosed herein are devices, methods and kits for a stent for treating an eye, comprising a flexible material, wherein the stent is self adaptive to a dimension of a vitreous cavity in the eye.

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Номер записи: 13
16-02-2012 дата публикации

Apparatus and Method for Capsule Formation in Tissue

Номер: US20120041393A1
Автор: Donald Shannon, Frank Ahmann, Hani Sabbah
Принадлежит: CARDIOPOLYMERS Inc, HENRY FORD HEALTH SYSTEM

Capsules, emplacement apparatus, and associated methods for establishing a capsule within tissue are described herein. The emplacement apparatus may be catheter-based or implemented in a handheld unit. The emplacement apparatus serves to introduced an encapsulating membrane in a collapsed condition into the tissue, and then to expand the encapsulating membrane within the tissue into a capsule by injection of fill material into the encapsulating membrane. Other than being capable of injection through the emplacement apparatus, the fill material may be selected and formulated to achieve such mechanical and biological properties within the encapsulating membrane after injection as are desired to achieve the therapeutic effect sought for the patient. Mechanically, the fill material within the encapsulating membrane after injection may be a liquid, a semi-solid such as a gel, or a solid such as a cross-linked polymer. The fill material may or may not be sealed within the encapsulating membrane.

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Номер записи: 14
16-02-2012 дата публикации

Biologic treatment system and method

Номер: US20120041418A1
Автор: Thomas Q. Dinh
Принадлежит: AMS Research LLC

A delivery system is provided that is adapted to treat various urological pelvic disorders, such as prolapse, incontinence, and the like. The delivery system can include at least one biologic loaded or otherwise provided with a bioactive agent. The biologic can comprise any drugs, hormones or steroids, stem cells, growth factors, proteins, and/or other bioactive agents to promote cell or tissue growth for the treatment and strengthening of organ walls or tissue. The biologic is generally adapted to controllably release the agent to the surrounding tissue or organ to provide a local and targeted delivery.

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Номер записи: 15
23-02-2012 дата публикации

Plasma modification of metal surfaces

Номер: US20120046735A1
Автор: Habib Skaff, Kevin N. Sill, Kurt Breitenkamp
Принадлежит: Intezyne Technologies Inc

The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials.

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Номер записи: 16
01-03-2012 дата публикации

Coating System, Articles and Assembly Using the Same and Methods of Reducing Sticktion

Номер: US20120053530A1
Автор: Xia Zhao, Yongming Liu
Принадлежит: Becton Dickinson and Co

The present invention provides a coating system for an article including a first component having a surface in frictional engagement with a surface of a second component, wherein at least a portion of at least one surface of the component(s) is coated with a coating prepared from a composition including a first, curable organopolysiloxane comprising at least two alkenyl groups; and a second, curable organopolysiloxane comprising at least two polar groups, the second organopolysiloxane being different from the first organopolysiloxane, which can provide low breakloose force when used in syringe assemblies.

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Номер записи: 17
01-03-2012 дата публикации

Implant and method for producing the same

Номер: US20120053679A1
Автор: Frank Endres, Horst Fircho, Ullrich Bayer
Принадлежит: BIOTRONIK AG

An implant and method for producing an implant, in particular an intraluminal endoprosthesis, with a body, wherein the body contains iron or an iron alloy, comprising the following steps: a) providing the implant body ( 1 ), b) applying a metallic coating comprising as main constituent at least one element of the group containing tantalum, niobium, zirconium, aluminum, magnesium, vanadium, molybdenum, hafnium, and wolfram onto at least a portion of the body surface, and c) plasmachemical treatment of the portion of the body surface provided with the coating in an aqueous solution for producing a plasmachemically generated layer ( 3, 5, 7 ) by means of applying a plasma-generating pulsating voltage to the body of the implant, wherein the pulsating voltage has sufficient energy that the metallic coating ( 3, 5, 7 ) is temporarily and sectionally ionized up to the underlying implant body ( 1 ) in such a manner that the generated layer has pores ( 5 ) which extend at least partially up to the implant body.

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Номер записи: 18
08-03-2012 дата публикации

Biological tissue connection and repair devices and methods of using same

Номер: US20120059399A1
Автор: Ahmet Hoke, Hai-quan Mao
Принадлежит: JOHNS HOPKINS UNIVERSITY

The instant invention provides compositions and methods for promoting the repair and/or growth of biological tissue, e.g., tubular biological tissue such as nerves. Specifically, the instant invention provides tissue connection devices and tissue repair devices and methods for using these devices.

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Номер записи: 19
08-03-2012 дата публикации

Method of Manufacturing a Polymeric Stent Having Reduced Recoil

Номер: US20120059451A1
Автор: Joseph H. Contiliano, Qiang Zhang
Принадлежит: Advanced Technologies and Regenerative Medicine LLC

Methods of manufacturing polymeric intraluminal stents, and stents made by such methods, are disclosed. The methods provide for manufacturing polymeric intraluminal stents by inducing molecular orientation in the stents by radial compression thereby providing stents with low recoil post-deployment.

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Номер записи: 20
22-03-2012 дата публикации

Reduced profile medical balloon element

Номер: US20120070599A1
Автор: Alan M. Zamore
Принадлежит: Individual

Medical dilatation balloons comprise a polymer that has the attribute of memory, and/or is crosslinked to impart memory. Such balloons exhibit a reduced tendency to overinflate at high inflation pressures. Furthermore, such balloons when shrunk radially by the application of heat while restraining axial shrinkage, exhibit customizable linear or non-linear compliance curves and lower crosslinking profile relative to the same balloon when unshrunk. Also disclosed is an expansive element within a tube whose outer diameter is equal to the outer diameter of the tube from which it was made. In addition, disclosed are (a) processes for preparing crosslinkable polymers, (b) joining crosslinked balloons to catheter systems, (c) forming shrunk balloon elements, and (d) forming an expansive element within a tube whose outer diameter is equal to the outer diameter of the tube from which it was made.

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Номер записи: 21
29-03-2012 дата публикации

Post-biopsy cavity treatment implants and methods

Номер: US20120076733A1
Автор: Ary S. Chernomorsky, James W. Vetter, Simon Chernomorsky
Принадлежит: Chernomorsky Ary S, Simon Chernomorsky, VETTER JAMES W

A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix defining a first controlled pore architecture. The shell portion is coupled to the core portion and includes a second porous matrix defining a second controlled pore architecture that is different from the first controlled pore architecture.

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Номер записи: 22
12-04-2012 дата публикации

Implantable Drug Delivery Device with Bladder Retention Feature

Номер: US20120089121A1
Автор: Heejin Lee, Hong Linh Ho Duc
Принадлежит: Taris Biomedical Inc

Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder Which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.

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Номер записи: 23
19-04-2012 дата публикации

Method To Minimize Chain Scission And Monomer Generation In Processing of Poly(L-Lactide) Stent

Номер: US20120091633A1
Автор: James Oberhauser, Yunbing Wang
Принадлежит: Abbott Cardiovascular Systems Inc

Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD.

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Номер записи: 24
10-05-2012 дата публикации

Activation and delivery devices for therapeutic compositions

Номер: US20120116300A1
Автор: Braden C. Fleming, David M. Skinlo, Emma Wright, Katie A. Bush, Martha M. Murray, Matthew Palmer, Samuel D. Banks, JR., Thomas D. Egan, Thomas P. Weisel
Принадлежит: Individual

Devices and methods for activating a therapeutic composition, delivering a therapeutic composition to a specific region or tissue in a body, and containing a therapeutic composition within a body cavity are disclosed herein. In one embodiment, a therapeutic capsule is shown having an outer element defining an interior chamber and including a matrix disposed therein and wherein the interior chamber is elongated along a chamber axis.

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Номер записи: 25
17-05-2012 дата публикации

Enhancing biocompatibility of a medical device

Номер: US20120121657A1
Автор: Anna Norlin-Weissenrieder, Biyun Wu, Stephanie M. Board, Zhengrong Zhou
Принадлежит: St Jude Medical LLC

The present invention relates to a medical device comprising both pyrolytic carbon and an NO generator, methods of making same, and methods of using same.

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Номер записи: 26
17-05-2012 дата публикации

Functionalized rgd peptidomimetics and their manufacture, and implant having a coating containing such functionalized rgd peptidomimetics

Номер: US20120121658A1
Автор: Alexander Borck, Florian Rechenmacher, Horst Kessler, Matthias Gratz, Michael Joner, Stefanie Neubauer
Принадлежит: BIOTRONIK AG

At least some embodiments of the invention relates to an implant having a coating that contains or is composed of a functionalized RGD peptidomimetic RGD-P1 having the formula (1) and/or a functionalized RGD peptidomimetic RGD-P2 having the formula (2), and an associated manufacturing method.

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Номер записи: 27
17-05-2012 дата публикации

Neurological apparatus

Номер: US20120123391A1
Автор: Hugo George Derrick, Mathew David Frederick Stratton, Stephen Streatfield Gill
Принадлежит: Renishaw Ireland Ltd

A guide element for insertion into the brain to guide implantable instruments, wherein the guide element comprises an elongate part, the elongate part having a composition of at least 80% tungsten carbide. The guide element may have a coating, such as a biocompatible plastics material which is more resilient than the elongate part.

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Номер записи: 28
31-05-2012 дата публикации

Phosphorylcholine-based amphiphilic silicones for medical applications

Номер: US20120136087A1
Автор: Ananth V. Iyer, Anfeng Wang, James Parakka, Robert Ward, Xuwei Jiang, Yuan Tian
Принадлежит: DSM IP ASSETS BV

Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.

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Номер записи: 29
07-06-2012 дата публикации

Cell coated implantable device

Номер: US20120141562A1
Автор: George A. Truskey, Hardean E. Achneck, Ryan M. Jamiolkowski
Принадлежит: Achneck Hardean E, Jamiolkowski Ryan M, Truskey George A

The present invention relates, in general, to a cell-coated implantable medical device and, in particular, to an implantable medical device the blood-contacting surfaces of which are coated with endothelial progenitor cells (EPCs). In a preferred embodiment, the medical device is a titanium or titanium alloy-based medical device.

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Номер записи: 30
07-06-2012 дата публикации

Magnesium-Based Absorbable Implants

Номер: US20120143227A1
Автор: Ioannis Pandelidis, Mark Steckel
Принадлежит: Zorion Medical Inc

A bioabsorbable implant including an elongated metallic element comprising an alloy of more than about 70% by weight magnesium and about 2-20% by weight lithium, substantially free of rare earth metals. An implantable tissue filler includes a particulate material suspended in a carrier, comprising more than about 70% by weight magnesium and about 2-20% by weight lithium, substantially free of rare earth metals. A bioabsorbable implant includes an elongated metallic element having a core and at least two layers of alternating compositions of magnesium, iron, and alloys thereof. A bioabsorbable implant includes at least three wires including magnesium and defining a cylindrical sheath surrounding at least one core wire including iron. A bioabsorbable implant includes a plurality of intertwined magnesium alloy wires defining a strand, with an Fe-rich layer formed by vapor, chemical and/or electro-deposition defined on a surface of at least one of the wires.

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Номер записи: 31
14-06-2012 дата публикации

Stent formed from crosslinked bioabsorbable polymer

Номер: US20120149850A1
Автор: Lothar W. Kleiner
Принадлежит: Abbott Cardiovascular Systems Inc

A stent having a stent body made from a crosslinked bioabsorbable polymer is disclosed. A method of making the stent including exposing a tube formed from a bioabsorbable polymer to radiation to crosslink the bioabsorbable polymer and forming a stent body from the exposed tube is disclosed. The tube can include a crosslinking agent which induces crosslinking upon radiation exposure. Additionally or alternatively, the bioabsorbable polymer can be a copolymer that crosslinks upon exposure to radiation in the absence of a crosslinking agent.

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Номер записи: 32
14-06-2012 дата публикации

Implantable or insertable medical devices for controlled drug delivery

Номер: US20120150096A1
Автор: Cang Duy Dao, Danielle Conley, Hamid Davoudi, Jianmin Li, Kathleen M Miller, Raymond J. Lareau, Weenna Bucay-Couto
Принадлежит: Boston Scientific Scimed Inc

Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.

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Номер записи: 33
21-06-2012 дата публикации

Minimal tissue attachment implantable materials

Номер: US20120157673A1
Автор: Constance Ace, Gonzalo Serafica, Jeremy Harris
Принадлежит: Xylos Corp

A method for minimizing tissue adhesion at an injured site is provided, the method comprising applying a biocellulose material to the injured site, whereby the adhesion of the tissues at the injured site is minimized, wherein the biocellulose material is at least partially dehydrated. Another embodiment provides an implantable material, which effectively prevents cell adhesion and has desirable mechanical properties.

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Номер записи: 34
21-06-2012 дата публикации

Surgical Implant

Номер: US20120158136A1
Автор: Adrian Baumgartner, Christian Brunner, Cyril Voisard
Принадлежит: Synthes USA LLC

A surgical implant comprises a body having a compressed state and an uncompressed state. An envelope contains the body in at least the compressed state. The envelope forms an air-tight seal around the body in the compressed state and is water-soluble or degradable in body fluids.

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Номер записи: 35
12-07-2012 дата публикации

Structural hydrogel polymer device

Номер: US20120178874A1
Автор: Scott M. Epstein
Принадлежит: Individual

The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stents are particular examples, and their composition, mechanical characteristics, and the significantly unique ability to conduct and allow fluids to pass from one end to the other without physiological rejection, inflammation, or manifestation of complications due to implant or otherwise undesirable outcomes when used for ambulatory and or therapeutic interventions is the purpose of the invention.

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Номер записи: 36
12-07-2012 дата публикации

Intraluminal polymeric devices for the treatment of aneurysms

Номер: US20120179193A1
Автор: Daniel Cohn, Itai Pelled, Ram Malal, Randa Abbas
Принадлежит: Yissum Research Development Co of Hebrew University of Jerusalem

Novel medical devices and uses thereof for lining a blood vessel and/or treating an aneurysm are disclosed herein. The device comprises a non-metallic expandable tubular structure, implantable in a body vessel and being made, at least in part, from a polymeric system characterized by a stiffness which changes upon stimulation under physiological conditions. Novel polymeric systems are further disclosed herein, which are configured to produce a polymeric material upon stimulation under physiological conditions, such that a stiffness of said polymeric material is higher than a stiffness of said system. Uses of polymer systems in the manufacture of a device are further disclosed.

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Номер записи: 37
19-07-2012 дата публикации

Supporting and Forming Transitional Material for Use in Supporting Prosthesis Devices, Implants and to Provide Structure in a Human Body

Номер: US20120184974A1
Автор: Hilton Becker
Принадлежит: Individual

A biocompatible fabric comprised of a strong absorbable material and ultra fine permanent fibers which serve as a collagen support system for prosthesis devices and implants. The permanent fibers stimulate the growth of collagen but are too weak to offer the initial support desired. As the absorbable material dissolves, the collagen formed over the permanent fiber assumes the support role from the absorbable material. The supporting system is natural in appearance and motion without encapsulation or rigidity. The absorbable material can be overlaid with the non-absorbable fiber which after absorption leaves the non-absorbable mesh in an array. The fibers can be discontinuous, loosely woven or embedded in an absorbable material and can be patterned to provide various strengths and degrees of motion and movement. The materials can be coated or infused with materials to reduce infection, provide tissue growth, reduce scar tissue or other medicinal purposes.

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Номер записи: 38
26-07-2012 дата публикации

Biodegradable endoprostheses and methods for their fabrication

Номер: US20120187606A1
Автор: John Yan, Vinayak Bhat, Xiaoxia Zheng
Принадлежит: Elixir Medical Corp

Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

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Номер записи: 39
02-08-2012 дата публикации

Implantable devices

Номер: US20120195958A1
Автор: Faisal Sharif, Jim Crowley, Sean Hynes, Timothy O'brien, Udo Greiser
Принадлежит: National University of Ireland Galway NUI

The present invention relates to implantable devices, which are coated or coatable with liposomes. The present invention further relates to liposomes encapsulating nucleic acids termed lipoplexes, to methods for the manufacture and coating of such implantable devices, and to the use of such implantable devices to improve treatment of patients with coronary artery disease or other vascular diseases and cancers.

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Номер записи: 40
09-08-2012 дата публикации

Medical product comprising a chitosan-coated wall and a method for manufacturing a medical product

Номер: US20120203326A1
Автор: Rivelino Montenegro, Thomas Freier
Принадлежит: MEDOVENT GMBH

A method for manufacturing a medical product comprising a hollow body ( 2 ), wherein at least part of a wall of the hollow body ( 2 ) is coated at least on the inside with a layer comprising a polymer; at least the part of at least the inside of the wall of the medical product is brought into contact with a mixture ( 6 ) of the polymer and the polymer is deposited from the mixture ( 6 ) on at least the part of the inside of the wall. And a medical product comprising a hollow body ( 2 ) with a wall consisting of one or more structural elements ( 16 ), at least a section of the wall being coated with a layer ( 15 ) comprising native chitosan, wherein both on the inside and the outside of the hollow body ( 2 ) at least some of the one or more structural elements ( 16 ) of the wall of the hollow body ( 2 ) are at least partly coated with the native chitosan layer ( 15 ). And a method for electrodepositing a polymer on an electrode from an acidic mixture of the polymer, wherein the mixture ( 6 ) comprises a multibasic acid.

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Номер записи: 41
13-09-2012 дата публикации

Methods for fabricating polymer-bioceramic composite implantable medical devices

Номер: US20120228810A1
Автор: Bin Huang, David C. Gale
Принадлежит: Advanced Cardiovascular Systems Inc

Methods relating to polymer-bioceramic composite implantable medical devices are disclosed.

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Номер записи: 42
13-09-2012 дата публикации

Stent fabrication via tubular casting processes

Номер: US20120232643A1
Автор: Alfred N. K. CHIA, Kamal Ramzipoor, Liwei Wang
Принадлежит: Amaranth Medical Pte

Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

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Номер записи: 43
27-09-2012 дата публикации

Bioresorbable nitric oxide agonist prodrug scaffolds for vascular stents

Номер: US20120245677A1
Автор: Wayne H. Kaesemeyer
Принадлежит: PALMETTO PHARMACEUTICALS LLC

The present invention relates to a bioresorbable scaffold for a vascular stent comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone. The nitric oxide agonist is a statin or a HMG CoA reductase inhibitor. The nitric oxide agonist may be coated on the polymer, incorporated within the polymer or chemically bonded to the polymer. The invention also relates to a method for treating atherothrombosclerotic occlusive disease of an artery comprising implanting into the artery a stent with a bioresorbable scaffold comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone, wherein the nitric oxide agonist is exuded from or released from the bioresorbable scaffold.

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Номер записи: 44
04-10-2012 дата публикации

System and Method for Formation of Biodegradable Ultra-Porous Hollow Fibers and Use Thereof

Номер: US20120248658A1
Автор: Roland Ostapoff, Seth Gleiman
Принадлежит: COVIDIEN LP

A system and method for forming biodegradable ultra-porous hollow fibers are disclosed. The fibers are formed by electrospinning a liquid polymer composition (e.g., solution) of a high molecular weight aliphatic polyester in a controlled environment.

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Номер записи: 45
18-10-2012 дата публикации

In-Situ Forming Foams for Treatment of Aneurysms

Номер: US20120265287A1
Автор: Gregory Zugates, Rany Busold, Toby Freyman, Upma Sharma
Принадлежит: Arsenal Medical Inc

Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms are disclosed. The systems include an insertable medical device and an in-situ forming foam that is formed from a polymer that reacts in an aqueous environment. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.

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Номер записи: 46
25-10-2012 дата публикации

Marked precoated medical device and method of manufacturing same

Номер: US20120271248A1
Автор: Bruce Nesbitt, Charles Berkelhamer
Принадлежит: Innovatech Inc

A method of manufacturing a coated medical device, such as a medical guide wire, including at least applying a first colored coating to at least a first portion of an outer surface of a medical guide wire, securing a first end of the medical guide wire, and for each a designated quantity of turns, turn a second end of the medical guide wire upon a longitudinal axis of the medical guide wire. The method of manufacturing also includes securing the second end of the medical guide wire, blocking at least a first portion of the coated surface of the medical guide wire, applying a second contrasting colored coating to at least a second, unblocked portion of the outer surface of the medical guide wire and releasing the first end and the second end of the medical guide wire to display at least one spiral marking formed along a length of the medical guide wire.

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Номер записи: 47
22-11-2012 дата публикации

Method and device for loading medical appliance with medicaments and/or polymers

Номер: US20120294499A1
Автор: Bo YI, Changsheng Wu, Jie Zhang, Qiyi Luo, Zhirong Tang
Принадлежит: Microport Medical Shanghai Co Ltd

A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.

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Номер записи: 48
22-11-2012 дата публикации

Bioabsorbable stent

Номер: US20120296415A1
Автор: Makoto Onishi, Yotaro Fujita
Принадлежит: Terumo Corp

A bioabsorbable stent has a relatively high radial force and can be placed directly at the lesion without the possibility or reducing the possibility of occluding the lesion again after placement. The bioabsorbable stent is formed from a mixture composed of a bioabsorbable aliphatic polyester and an aromatic compound having one or more aromatic rings.

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Номер записи: 49
29-11-2012 дата публикации

Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use

Номер: US20120302654A1
Автор: Gregory M. Cruise, Michael J. Constant
Принадлежит: MicroVention Inc

Generally, hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. These hydrogels may be prepared in many forms including pellets, filaments, and particles. Biomedical uses of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand in situ.

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Номер записи: 50
06-12-2012 дата публикации

Localized delivery of drug agents

Номер: US20120310159A1
Автор: Charles D. Lennox
Принадлежит: Boston Scientific Scimed Inc

Medical devices including a substrate that are expandable from a compressed state to an expanded state; a coating on the substrate, the coating having a drug agent incorporated therein; and a sheath over the coating. The sheath is expandable from a compressed state to an expanded state and has at least one perforation therein. The medical devices are configured such that when the substrate is in a compressed state, the sheath is also in a compressed state and the perforation is substantially closed. When the substrate is in an expanded state, the sheath is also in an expanded state and the perforation is substantially open. The invention also includes a method of using the medical devices for the controlled, localized delivery of a drug agent to a target location within a mammalian body.

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Номер записи: 51
27-12-2012 дата публикации

Peptide Based Antimicrobial Coating

Номер: US20120328556A1
Автор: Jan J. Lewandowski, Yubiao LIU
Принадлежит: Greatbatch Ltd

A comb-like surfactant polymer for changing the surface properties of biomaterials is described. The surfactant polymer comprises a polymeric backbone of repeating monomeric units having functional groups for chemically attaching to side chains, a plurality of hydrophobic side chains attached to the backbone via the functional groups and a plurality of hydrophilic side chains chemically attached via functional groups to the polymeric backbone. The hydrophilic side chains providing anti-thrombogenic properties to the surfactant. An antimicrobial agent selectively attached to some hydrophilic side chains thereby providing additional antimicrobial properties to the surfactant. The surfactant polymer may be applied to the surface of medical devices to reduce the surfaces thrombogenicity and decrease the number of microorganisms on the surface.

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Номер записи: 52
27-12-2012 дата публикации

Methods For Modulating The Release Rate Of A Drug-Coated Stent

Номер: US20120328770A1
Автор: Fuh-Wei Tang, Lothar Walter Kleiner, Ni Ding, Shaw Ling Hsu, Syed Faiyaz Ahmed Hossainy, Yiwen Tang
Принадлежит: Abbott Cardiovascular Systems Inc

Methods for modulating the release rate of a drug coated stent are disclosed.

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Номер записи: 53
27-12-2012 дата публикации

Elastomeric Copolymer Coatings For Implantable Medical Devices

Номер: US20120330404A1
Автор: Yunbing Wang
Принадлежит: Abbott Cardiovascular Systems Inc

Implantable medical devices with elastomeric copolymer coatings are disclosed.

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Номер записи: 54
17-01-2013 дата публикации

Method for fabricating medical devices with porous polymeric structures

Номер: US20130017313A1
Автор: Kumin Yang, Neftali Fernandez
Принадлежит: Abbott Cardiovascular Systems Inc

Medical articles with porous polymeric structures and methods of forming thereof are disclosed. The porous structure can have pores sizes that are nanoporous or greater than nanoporous. The porous structure can be a coating or layer of a medical device such as a stent, stent graft, catheter, or lead for pacemakers or implantable cardioverter defibrillators. Additionally, the body of the medical device can be a porous polymeric structure. The porous structure can be made from bioabsorbable polymers. The porous structures can be formed by contacting a polymer with a supercritical fluid.

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Номер записи: 55
07-02-2013 дата публикации

Method for Making Medical Devices Having Antimicrobial Coatings Thereon

Номер: US20130034593A1
Автор: John Martin Lally, Lynn Cook Winterton, Michael F. Rubner, Sung Yun Yang, Yongxing Qiu Qiu
Принадлежит: NOVARTIS AG

The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag + ions associated with the —COO − groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.

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Номер записи: 56
07-02-2013 дата публикации

Polymer-Based Occlusion Devices, Systems and Methods

Номер: US20130035665A1
Автор: Chaokang Chu, Edward Emil Shaw, Edward H. Cully, Eric H. Zacharias, Jeffrey Duncan, Krzysztof R. Pietrzak, Michael J. Vonesh, Robert L. Cleek
Принадлежит: WL Gore and Associates Inc

A method of occluding includes imbibing a porous elongate element comprised of ePTFE with a calcium-containing solution. The method also includes delivering, via a delivery catheter, the calcium-imbibed porous elongate element to a target occlusion site. The method further includes administering, after the calcium-imbibed porous elongate element has been completely delivered to the target occlusion site and resides entirely within a volume defined by the target occlusion site, an alginate-containing solution to the target occlusion site.

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Номер записи: 57
14-02-2013 дата публикации

Method of making polymer-bioceramic composite implantable medical devices

Номер: US20130041065A1
Автор: Bin Huang, David C. Gale, Garth L. Wilkes, Syed Faiyaz Ahmed Hossainy, Vincent J. Gueriguian, Yunbing Wang
Принадлежит: Advanced Cardiovascular Systems Inc

Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed.

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Номер записи: 58
14-02-2013 дата публикации

Limus-coated medical devices

Номер: US20130041315A1
Автор: Ulrich Speck
Принадлежит: Cordis Corp, InnoRa GmbH

The present invention is related to a medical device carrying at least on a portion of its surface a Limus drug or Limus drug preparation and butylated hydroxytoluene at a ratio of 3-100% by weight of butylated hydroxytoluene in relation to 100% by weight of the Limus drug.

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Номер записи: 59
28-02-2013 дата публикации

Triple Balloon Occlusion and Infusion Catheter

Номер: US20130053758A1
Автор: Melina R. Kibbe
Принадлежит: Northwestern University

Disclosed are balloon catheters for forming liquid cast biodegradable arterial stents, typically, the balloon catheters include multiple balloons and multiple ports and include an element for promoting or initiating curing of a polymer solution via polymerization or cross-linking.

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Номер записи: 60
07-03-2013 дата публикации

Implant made of a biodegradable magnesium alloy

Номер: US20130060326A1
Автор: Bodo Gerold
Принадлежит: BIOTRONIK VI PATENT AG

An implant made in total or in parts of a biodegradable magnesium alloy consisting of Y: 2.0-6.0% by weight, Nd: 1.5-4.5% by weight, Gd: 0-4.0% by weight, Dy: 0-4.0% by weight, Er: 0-4.0% by weight, Zr: 0.1-1.0% by weight, Li:0-0.2% by weight, Al: 0-0.3% by weight, under the condition that a) a total content of Er, Gd and Dy is in the range of 0.5-4.0% by weight and b) a total content of Nd, Er, Gd and Dy is in the range of 2.0-5.5% by weight, the balance being magnesium and incidental impurities up to a total of 0.3% by weight.

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Номер записи: 61
21-03-2013 дата публикации

COATINGS OF ACRYLAMIDE-BASED COPOLYMERS

Номер: US20130071449A1
Автор: Glauser Thierry, HOSSAINY Syed Faiyaz Ahmed, Trollsas Mikael O.
Принадлежит: Abbott Cardiovascular Systems Inc.

An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. 2. The implantable device of claim 1 , wherein the linker comprises succinic anhydride claim 1 , glutaric anhydride claim 1 , dimethyl succinic anhydride claim 1 , methyl glutaric anhydride claim 1 , a thioester claim 1 , a disulfide bond claim 1 , a PLA-oligomer claim 1 , a PLGA-oligomer claim 1 , a PCL-oligomer claim 1 , an ester linkage claim 1 , or an anhydride linkage.3. The implantable device of claim 1 , wherein the linker comprises succinic anhydride claim 1 , glutaric anhydride claim 1 , dimethyl succinic anhydride claim 1 , or methyl glutaric anhydride.4. The implantable device of claim 1 , wherein the linker comprises poly(ethylene glycol) (PEG) claim 1 , an alkyl chain claim 1 , or a peptide sequence.5. The implantable device of claim 4 , wherein the peptide sequence comprises glycine-phenylalinine-leucine-glycine.6. The implantable device of claim 1 , wherein the linker comprises poly(ethylene glycol) (PEG) claim 1 , poly(alkylene oxide) claim 1 , C1-C12 alkyl claim 1 , C1-C12 cycloalkyl claim 1 , or C1-C12 aryl.7. The implantable device of claim 1 , wherein the copolymer is poly[N-(2-hydroxypropyl)methacrylamide-co-methoxyethyl methacrylate] (HPMA-co-MOEMA).8. The implantable device of claim 1 , wherein the copolymer is a random or block copolymer.9. The implantable device of claim 1 , which is a stent.10. The implantable device of claim 1 , wherein the bioactive agent is selected from the group consisting of halofuginone claim 1 , paclitaxel claim 1 , docetaxel claim 1 , estradiol claim 1 , 17-beta-estradiol claim 1 , a nitric oxide donor claim 1 , super oxide dismutase claim 1 , a super oxide dismutase mimic claim 1 , 4-amino-2 claim 1 ,2 claim 1 ,6 claim 1 ,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO) claim 1 , tacrolimus claim 1 , dexamethasone claim 1 , rapamycin claim 1 , a rapamycin derivative claim 1 , 40-O-(2-hydroxy)ethyl- ...

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Номер записи: 62
04-04-2013 дата публикации

CONTROLLING RESORPTION OF BIORESORBABLE MEDICAL IMPLANT MATERIAL

Номер: US20130084315A1
Автор: Baldwin Samuel, Harrah Timothy P., Li Jianmin
Принадлежит: BOSTON SCIENTIFIC SCIMED, INC.

The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles. 120-. (canceled)21. A coating material for use in a medical device for regulating resorption of said medical device , said coating material comprising (a) a bioresorbable ionically or covalently crosslinked polymeric material that allows diffusion into said medical device by a body fluid at a pre-selected rate; and (b) particles embedded in said bioresorbable polymeric material , said particles causing said bioresorbable polymeric material to resorb upon contact with a body fluid at a controllable resorption rate.221. The coating material of claim , wherein the resorption of said bioresorbable polymeric material is further controlled by varying the size or the amount of said embedded particles.231. The coating material of claim , wherein said controllable resorption rate is different from a resorption rate of said bioresorbable polymeric material without said embedded particles.241. The coating of claim composition of claim , wherein said bioresorbable polymeric material comprises an ionically cross-linkable polymeric material comprises at least one polymer ...

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Номер записи: 63
25-04-2013 дата публикации

Coating of endoprostheses with a coating consisting of a tight mesh of polymer fibers

Номер: US20130103139A1
Автор: Erika Hoffmann, Lutz Freitag, Michael Hoffmann, Roland Horres
Принадлежит: HEMOTEQ AG

The present invention relates to grid-like or net-like endoprosthesis having a continuous, respectively ongoing and interstices-spanning coating with a thread-tangle, wherein this continuous, respectively ongoing and interstices-spanning coating covers the struts as well as the interstices between the single endoprosthesis struts.

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Номер записи: 64
23-05-2013 дата публикации

Diagnostic system

Номер: US20130131479A1
Автор: Alison Ruth Norcott, Christopher David Dunn, Eric Siu, Ernesto Monis Hueso, Ian Frederick Johnson, John Michael Kelly, Richard Sokolov
Принадлежит: Individual

A composite diagnostic system comprising a support member having a membrane penetration element; a bodily fluid collection point positioned for collection of a bodily fluid released by application of the membrane penetration element to a user's body; a test material positioned in the support member such that in use the bodily fluid is brought into contact with the test material.

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Номер записи: 65
23-05-2013 дата публикации

Cell induction material

Номер: US20130131829A1
Автор: Akihiro Ametani, Kazutaka Yoshino
Принадлежит: Hi Lex Corp

The object of the present invention is to provide a cell induction material, which can be easily formed, has excellent moldability because sintering is unnecessary, and decreases a strain on a human body caused by the exposure of the ends of a titanium wire. A metal mesh made by stockinette stitching with titanium wire is formed into a predetermined shape, and a cell induction material obtained by pressing the formed metal mesh is used. Further, the cell induction material with substantially no ends of the titanium wire that can be sensed through the sense in the vicinity of the surface is used.

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Номер записи: 66
06-06-2013 дата публикации

Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices using Sonocrystallization

Номер: US20130142939A1
Автор: Homayon Askaryar, Qing Lin, Syed Faiyaz Ahmed Hossainy, Thierry Glauser, Yiwen Tang
Принадлежит: Advanced Cardiovascular Systems Inc

Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.

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Номер записи: 67
06-06-2013 дата публикации

Bioabsorbable device having composite structure for accelerating degradation

Номер: US20130144376A1
Автор: George Landau, Vipul Dave
Принадлежит: Cordis Corp

A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material encapsulating a degradation additive incorporated into the first biodegradable and/or bioabsorbable material. The second biodegradable and/or bioabsorbable material has a degradation rate that is faster than the degradation rate of the first biodegradable and/or bioabsorbable material such that the structure experiences a period of accelerated degradation upon release of the degradation additive following sufficient degradation of the second biodegradable and/or bioabsorbable material.

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Номер записи: 68
13-06-2013 дата публикации

Coated elastomeric article and method for making a coated elastomeric article

Номер: US20130145517A1
Автор: Andreas Brown, Anil Segat
Принадлежит: Precision Components Inc, Xela Corp

An elastomeric article, such as a glove or a condom, is coated with a compound containing silicone, collagen and allantoin.

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Номер записи: 69
13-06-2013 дата публикации

Coated elastomeric article and method for making a coated elastomeric article

Номер: US20130149354A1
Автор: Andreas Brown, Anil Segat
Принадлежит: Precision Components Inc, Xela Corp

An elastomeric article, such as a glove or a condom, is coated with a compound containing silicone, collagen and allantoin.

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Номер записи: 70
13-06-2013 дата публикации

Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices

Номер: US20130149431A1
Автор: Askaryar Homayon, Glauser Thierry, HOSSAINY Syed Faiyaz Ahmed, Lin Qing, Tang Yiwen
Принадлежит: Advanced Cardiovascular Systems, Inc.

Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. 1. A method of forming a coating on an implantable medical device , comprising:a) applying a powder of a drug in crystalline or partially crystalline form onto at least a portion of an implantable medical device;b) wrapping the implantable medical device on top of the drug with a sheet of a polymer; andc) heating the sheet of the polymer at a temperature above the glass transition temperature of the polymer to form a coating comprising the polymer on top of the drug.2. The method of claim 1 , wherein the powder of the drug comprises nano- or micro-particles of the drug.3. The method of claim 1 , wherein the polymer is selected from the group consisting of poly(ethylene glycol terephthalate)-co-poly(butylene terephthalate) claim 1 , hyaluronic acid claim 1 , poly(ethylene glycol) claim 1 , phosphoryl choline claim 1 , poly(amide ester) claim 1 , poly(D claim 1 ,L-lactide) claim 1 , polyhydroxyalkanoate claim 1 , polycaprolactone claim 1 , poly(vinylidene fluoride) claim 1 , poly(hexafluoro propylene) claim 1 , poly(ethylene vinyl alcohol) claim 1 , and combinations thereof.4. The method of claim 3 , wherein the drug is selected from the group consisting of ABT-578™ claim 3 , paclitaxel claim 3 , docetaxel claim 3 , tacrolimus claim 3 , pimecrolimus claim 3 , batimastat claim 3 , mycophenolic acid claim 3 , estradiol claim 3 , clobetasol claim 3 , dexamethasone claim 3 , rapamycin claim 3 , everolimus claim 3 , 40-O-(3-hydroxy)propyl-rapamycin claim 3 , 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin claim 3 , 40-O-tetrazole-rapamycin claim 3 , 4-amino-2 claim 3 ,2 claim 3 ,6 claim 3 ,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO) claim 3 , and combinations thereof.5. The method of claim 1 , wherein the crystallinity ...

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Номер записи: 71
13-06-2013 дата публикации

Antimicrobial Medical Devices Containing Chlorhexidine Free Base and Salt

Номер: US20130150452A1
Автор: Modak Shanta M., Sampath Lester A.
Принадлежит: The Trustees of Columbia University in the City of New York

The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1. 1. An antimicrobial medical article prepared by treating a hydrophobic polymeric medical article , for an effective period of time , with a solution consisting essentially of one or more solvents and a mixture of chlorhexidine free base and a water-soluble chlorhexidine salt , wherein the weight/weight ratio of chlorhexidine free base and the water-soluble chlorhexidine salt in the solution is between 1:1 to 1:5.214-. (canceled)15. The antimicrobial medical article of claim 1 , wherein the article is expanded polytetrafluoroethylene.16. The antimicrobial medical article of claim 1 , wherein the article is a polytetrafluoroethylene soft tissue patch.1720-. (canceled)21. A method of preparing a medical article comprising the steps of:(i) placing the medical article in a solution consisting essentially of (a) a solvent selected from the group consisting of water, reagent alcohol, tetrahydrofuran, dimethylsulfoxide, dimethylformamide, N-methyl-2-pyrrolidone, and mixtures thereof; and (b) a mixture of chlorhexidine free base and a water-soluble chlorhexidine salt, wherein the weight/weight ratio of chlorhexidine free base and water-soluble chlorhexidine salt in the solution is between 1:1 to 1:5;(ii) soaking the medical article in the solution for an effective period of time to allow the medical article to swell;(iii) removing the medical article from the solution; and(iv) drying the medical article.22. (canceled)23. The method of claim 21 , wherein the medical article is a hydrophobic polymeric medical article.24. The method of claim 23 , wherein the hydrophobic polymeric medical article is selected from the group consisting of expanded polytetrafluoroethylene and a polytetrafluoroethylene ...

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Номер записи: 72
13-06-2013 дата публикации

Coatings for drug delivery devices

Номер: US20130150460A1
Автор: Stephen Dirk Pacetti
Принадлежит: Advanced Cardiovascular Systems Inc

A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.

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Номер записи: 73
13-06-2013 дата публикации

Kits Including Implantable Medical Devices and Antioxidants

Номер: US20130150953A1
Автор: Ni Ding
Принадлежит: Abbott Cardiovascular Systems Inc

Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices.

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Номер записи: 74
20-06-2013 дата публикации

METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS

Номер: US20130156844A1
Автор: Kaplan David L., WANG Xianyan
Принадлежит: TRUSTEES OF TUFTS COLLEGE

The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications. 1. A composition comprising a substrate coated with silk fibroin , wherein the silk fibroin coating the substrate comprises a therapeutic agent.2. The composition of claim 1 , wherein the composition is selected from the group consisting of vascular wound repair devices claim 1 , hemostatic dressings claim 1 , patches claim 1 , glues claim 1 , and sutures.3. The composition of claim 1 , wherein the therapeutic agent comprises an agent for enhancing wound healing.4. The composition of claim 1 , wherein the therapeutic agent is selected from the group consisting of antiproliferatives claim 1 , antineoplastics claim 1 , antiinflammatories claim 1 , antiplatelets claim 1 , anticoagulants claim 1 , antifibrins claim 1 , antithrombins claim 1 , antimitotics claim 1 , antibiotics claim 1 , antioxidans claim 1 , and combinations thereof.5. The composition of claim 1 , wherein the composition is formulated for topical administration.6. The composition of claim 1 , wherein the therapeutic agent is present as a liquid or a finely divided solid.7. The composition of claim 1 , wherein the therapeutic is controlled released over a period of about 2 to about 90 days.8. The composition of claim 1 , wherein the therapeutic agent is released in an amount of about 1 ng/day to 1 mg/day.9. The composition of claim ...

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Номер записи: 75
20-06-2013 дата публикации

SAMPLE COLLECTION SYSTEM AND METHOD FOR USE THEREOF

Номер: US20130158431A1
Автор: ARONOWITZ JACK L.
Принадлежит:

A sample collection system capable of collecting, storing and dispensing a liquid sample is disclosed. The collection system includes a collector composed of a material which has the unique ability to express constituents of interest at levels which are more concentrated than their levels in the fluid samples from which they are expressed, where the expressed highly concentrated sample can then be used with modern rapid screening/testing protocols, such as solid phase assays, to test for the constituents of interest. Thus, it is now possible to obtain analytes of interest, such as the HIV protein antibodies, from saliva samples at concentrations that are representative of that found in serum or plasma. The collector is sized and shaped to fit within a recovery container, which, in turn, is sized and shaped to fit within a collection tube. The recovery container includes an aperture which does not permit passage of fluid under ambient conditions, but facilitates transfer thereof when subject to pressure. An optional channel within the collection tube facilitates dispensing of the sample for further processing. 1. A collector device for use with a saliva sample collection system , said collector device comprisinga closure for cooperating with a collecting container, anda collector connected to said closure for insertion into the collecting container when the closure is connected to the collecting container, wherein said collector is capable of collecting and storing a saliva sample including constituents of interest present in the saliva sample when said collector is strategically positioned in the mouth of an individual for a sufficient period of time, and wherein said collector is capable of expressing from the saliva sample constituents of interest in concentration levels which are representative of the concentrations for the constituents of interest found in serum or plasma.2. A collection system for collecting , storing and dispensing a fluid sample including ...

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Номер записи: 76
27-06-2013 дата публикации

CONTAINERS FOR COMPOSITIONS COMPRISING MELOXICAM

Номер: US20130161228A1
Автор: Crowley Samuel C., Folger Martin A., Wilson Amy J.
Принадлежит: BOEHRINGER INGELHEIM VETMEDICA GMBH

A plastic container containing a pharmaceutical composition comprising benzoic acid or a derivative or a pharmaceutically acceptable salt thereof and a COX-inhibitor of the oxicam-type or a pharmaceutical acceptable salt thereof, wherein the container material selected from one or more members of the group consisting of a homopolymer of polypropylene (PP), a copolymer of polypropylene (PP), a homopolymer of polyethylene terephthalate (PET) and a copolymer of polyethylene terephthalate (PET), and optionally one or more non-polymeric components. 1. A pharmaceutically acceptable container for containing a pharmaceutical composition including sodium benzoate , the container being formed of container material effective to prevent significant loss of the sodium benzoate during storage , wherein the container material is selected from the group consisting of a homopolymer of polypropylene (PP) , a copolymer of polypropylene (PP) , a homopolymer of polyethylene terephthalate (PET) and a copolymer of polyethylene terephthalate (PET).2. The container according to including a pharmaceutical composition comprising sodium benzoate stored in the container.3. The plastic container according to claim 2 , wherein the sodium benzoate is present in the composition in a concentration range of 0.8 mg/ml to 2.0 mg/ml.4. The container according to claim 2 , wherein the composition further comprises an oxicam-type COX-inhibitor or a pharmaceutical acceptable salt thereof claim 2 , the oxicam-type COX-inhibitor being selected from the group consisting of meloxicam claim 2 , piroxicam claim 2 , lornoxicam claim 2 , tenoxicam claim 2 , droxicam claim 2 , and isoxicam.5. The container according to claim 2 , wherein the composition further comprises meloxicam or a pharmaceutical acceptable salt thereof.6. The container according to claim 2 , wherein the container material does not include high-density polyethylene (HDPE) claim 2 , low-density polyethylene (LDPE) claim 2 , or polycarbonate (PC). ...

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Номер записи: 77
04-07-2013 дата публикации

Modified surface for an implantable device and a method of producing the same

Номер: US20130172974A1
Автор: Avijit Mukherjee, Shamim M. Malik
Принадлежит: Advanced Cardiovascular Systems Inc

Implantable devices, such as stents, having a surface modified with TiN x C y are disclosed.

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Номер записи: 78
04-07-2013 дата публикации

Implantable product with improved aqueous interface characteristics and methods for making and using the same

Номер: US20130172980A1
Автор: Alonzo D. Cook, Robert C. Krall, Warren J. Cutright, William D. Montgomery
Принадлежит: WL Gore and Associates Inc

An implantable medical device including a porous membrane that is treated with a hydrophilic substance to obtain rapid optimum visualization using technology for viewing inside of a mammalian body. These technologies include ultrasound echocardiography and video imaging such as that used during laparoscopic procedures.

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Номер записи: 79
04-07-2013 дата публикации

MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE AND DIFFERENTIATION

Номер: US20130172988A1
Автор: Cottone, JR. Robert J., Kuliszewski Michael A., Kutryk Michael J. B., Rowland Stephen M.
Принадлежит: Orbus Medical Technologies Inc.

Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed. 1. An implantable medical device comprising a multiple layer coating matrix attached to at least a portion of said medical device , wherein said matrix promotes the capture and growth of endothelial cells or endothelial progenitor in vivo.2. The implantable medical device of claim 1 , wherein the medical device is selected from the group consisting of a stent claim 1 , a stent graft claim 1 , a synthetic vascular graft claim 1 , a heart valve claim 1 , a catheter claim 1 , a vascular prosthetic filter claim 1 , a pacemaker claim 1 , a pacemaker lead claim 1 , a defibrillator claim 1 , a patent foramen oval septal closure device claim 1 , a vascular clip claim 1 , a vascular aneurysm occluder claim 1 , a hemodialysis graft claim 1 , a hemodialysis catheter claim 1 , an atrioventricular shunt claim 1 , an aortic aneurysm graft device claim 1 , a venous valve claim 1 , a suture claim 1 , a vascular anastomosis clip claim 1 , an indwelling venous catheter claim 1 , an indwelling arterial catheter claim 1 , a vascular sheath and a drug delivery port.3. The implantable medical device of claim 1 , wherein the ...

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Номер записи: 80
04-07-2013 дата публикации

Supporting and forming transitional material for use in supporting prosthesis devices, implants and to provide structure in a human body

Номер: US20130172994A1
Автор: Hilton Becker
Принадлежит: Individual

A fabric for use in the human body composed of non-absorbable micro diameter threads contained in absorbable materials, such that over time the absorbable material dissolves or is absorbed by the body and the non-absorbable micro diameter threads cause the body to create a collagen scaffold transferring load from the absorbable material to the collagen scaffold. The fabric can be coated or impregnated with materials to reduce infection, provide tissue growth, reduce scar tissue or other medical purpose. Threads of non-absorbable material can be coated with absorbable material to create a fabric.

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Номер записи: 81
11-07-2013 дата публикации

Method for imparting improved fatigue strength to wire made of shape memory alloys, and medical devices made from such wire

Номер: US20130174631A1
Автор: Jeremy E. Schaffer
Принадлежит: Fort Wayne Metals Research Products LLC

Wire products, such as round and flat wire, strands, cables, and tubing, are made from a shape memory material in which inherent defects within the material are isolated from the bulk material phase of the material within one or more stabilized material phases, such that the wire product demonstrates improved fatigue resistance. In one application, a method of mechanical conditioning in accordance with the present disclosure isolates inherent defects in nickel-titanium or NiTi materials in fields of a secondary material phase that are resistant to crack initiation and/or propagation, such as a martensite phase, while the remainder of the surrounding defect-free material remains in a primary or parent material phase, such as an austenite phase, whereby the overall superelastic nature of the material is preserved.

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Номер записи: 82
18-07-2013 дата публикации

Articles Including Expanded Polytetrafluoroethylene Membranes with Serpentine Fibrils and Having a Discontinuous Fluoropolymer Layer Thereon

Номер: US20130184807A1
Автор: Larry J. Kovach, Rachel Radspinner
Принадлежит: WL Gore and Associates Inc

Articles comprising an expanded polytetrafluoroethylene membrane having serpentine fibrils and having a discontinuous coating of a fluoropolymer thereon are provided. The fluoropolymer may be located at least partially in the pores of the expanded fluoropolymer membrane. In exemplary embodiments, the fluoropolymer is fluorinated ethylene propylene. The application of a tensile force at least partially straightens the serpentine fibrils, thereby elongating the article. The expanded polytetrafluoroethylene membrane may include a microstructure of substantially only fibrils. The articles can be elongated to a predetermined point at which further elongation is inhibited by a dramatic increase in stiffness. In one embodiment, the articles are used to form a covered stent device that requires little force to distend in the radial direction to a first diameter but is highly resistant to further distension to a second diameter (stop point). A large increase in diameter can advantageously be achieved prior to reaching the stop point.

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Номер записи: 83
25-07-2013 дата публикации

MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING A THERAPEUTIC AGENT AND A CONTRAST AGENT

Номер: US20130189190A1
Автор: Wang Lixiao
Принадлежит: Lutonix, Inc.

The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive. 1. A medical device for delivering a therapeutic agent to a tissue , the device comprising a layer overlying an exterior surface of the medical device , the layer comprising a therapeutic agent , a contrast agent , and an additive , wherein:the additive comprises a hydrophilic part and a drug affinity part;the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions;the additive is water-soluble;the additive is at least one of a surfactant and a chemical compound; andthe contrast agent is chosen from iobitridol, iohexyl, iomeprol, iopamidol, iopentol, iopromide, ioversol, ioxilan, iotrolan, iodixanol, ioxaglate, and their derivatives.2. The medical device of claim 1 , wherein the chemical compound is chosen from amino alcohols claim 1 , hydroxyl carboxylic acid claim 1 , ester claim 1 , anhydrides claim 1 , hydroxyl ketone claim 1 , hydroxyl lactone claim 1 , hydroxyl ester claim 1 , sugar phosphate claim 1 , sugar sulfate claim 1 , ethyl oxide claim 1 , ethyl glycols claim 1 , amino acids claim 1 , peptides claim 1 , proteins claim 1 , sorbitan claim 1 , glycerol claim 1 , polyalcohol claim 1 , phosphates claim 1 , sulfates claim 1 , organic acids claim 1 , esters claim 1 , salts claim 1 , vitamins claim 1 , combinations of amino alcohol and organic acid claim 1 , and their substituted molecules.3. The medical device of claim 1 , wherein the surfactant is chosen from ionic claim 1 , nonionic claim 1 , aliphatic claim 1 , and aromatic surfactants claim 1 , PEG fatty esters claim 1 , PEG omega-3 fatty esters claim 1 , ether ...

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Номер записи: 84
25-07-2013 дата публикации

DRUG RELEASING COATINGS FOR MEDICAL DEVICES

Номер: US20130189329A1
Автор: Wang Lixiao
Принадлежит: Lutonix, Inc.

Medical device are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups. 1. A medical device for delivering a therapeutic agent to a tissue , the device comprising a layer overlying an exterior surface of the medical device , the layer comprising a therapeutic agent and an additive , wherein:the additive comprises a hydrophilic part and a drug affinity part;the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions; andthe additive is chosen from p-isononylphenoxypolyglycidol, PEG laurate, Tween 20, Tween 40, Tween 60, PEG oleate, PEG stearate, PEG glyceryl laurate, PEG glyceryl oleate, PEG glyceryl stearate, polyglyceryl laurate, plyglyceryl oleate, polyglyceryl myristate, polyglyceryl palmitate, polyglyceryl-6 laurate, plyglyceryl-6 oleate, polyglyceryl-6 myristate, polyglyceryl-6 palmitate, polyglyceryl-10 laurate, plyglyceryl-10 oleate, polyglyceryl-10 myristate, polyglyceryl-10 palmitate PEG sorbitan monolaurate, PEG sorbitan monolaurate, PEG sorbitan monooleate, PEG sorbitan stearate, PEG oleyl ether, PEG laurayl ether, octoxynol, monoxynol, tyloxapol, sucrose monopalmitate, sucrose monolaurate, decanoyl ...

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Номер записи: 85
25-07-2013 дата публикации

Surgical needle coatings and methods

Номер: US20130189422A1
Автор: Eric Hinrichs, Michael Hamilton, Robert Maurer, S. Neil Bar, Thomas Wilkes
Принадлежит: Ethicon Inc

The present invention provides improved medical devices for use in surgical procedures and methods for manufacturing improved medical devices. In some embodiments, the improved medical devices can include improved surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the improved surgical needles can be manufactured with two or more different coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Improved methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided.

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Номер записи: 86
01-08-2013 дата публикации

Biofilm resistant materials

Номер: US20130195841A1
Автор: Jeffrey S. Gabbay
Принадлежит: CUPRON SCIENTIFIC Ltd

This invention provides a biofilm resistant material comprising an active agent, which active agent consists essentially of an insoluble copper oxide at a concentration of between 3 and 10% w/w of said biofilm resistant material and uses thereof.

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Номер записи: 87
15-08-2013 дата публикации

Adhesive structure with stiff protrusions on adhesive surface

Номер: US20130206330A1
Автор: Audrey Yoke Yee HO, Chee Tiong Lim, Hong Yee Low, Isabel Rodriguez, Joseph Hammer, Kevin Cooper, Murty Vyakarnam, Sriram Natarajan
Принадлежит: Agency for Science Technology and Research Singapore, Ethicon Endo Surgery Inc

A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.

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Номер записи: 88
15-08-2013 дата публикации

Bis-(alpha-amino)-diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use

Номер: US20130210931A1
Автор: Huashi Zhang, Jie Da, Jonathan Macferran Hughes, Zaza D. Gomurashvili
Принадлежит: Medivas LLC

The present invention provides biodegradable, biocompatible bis-(α-amino acyl)-diol-diester-containing poly(ester amide) (PEA) and poly(ester urethane) (PEUR) co-polymer compositions with mechanical properties that can be readily tailored by selection of various combinations and proportions of the building blocks of the co-polymers. The compositions are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The co-polymer compositions, particles and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.

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Номер записи: 89
15-08-2013 дата публикации

Ultrasound Coupling Liquid and Container

Номер: US20130211250A1
Автор: Roberta Brocardo, Thierry Pechoux
Принадлежит: Theraclion SA

This invention relates to a coupling liquid for ultrasound devices, preferably high intensity focused ultrasound (HIFU). The coupling liquid comprises a liquid aqueous solution of at least one hydrophilic polymer having an average molecular mass of between 30,000 and 70,000 and at least one alcohol with a carbon chain of 1 to 7 carbon atoms. Also disclosed is a container ( 10 ) for an ultrasound coupling liquid having a thin wall.

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Номер записи: 90
22-08-2013 дата публикации

PHARMACEUTICAL AND MEDICAL CONTAINER

Номер: US20130213849A1
Автор: KUESTER Joachim, KUNZ Aurel, LANGE Ulrich, Langsdorf Andreas, LOEFFELBEIN Bernd, MEINEFELD Marcus, Ohlinger Axel, ROTHHAAR Uwe, THUERK Juergen
Принадлежит: SCHOTT AG

A container for pharmaceutical and medical applications made from glass, preferably from a borosilicate glass. The container is formed in the shape of a hollow body open at both its ends with a cylindrical portion having a wall thickness tolerance of maximally ±0.2 mm. The borosilicate glass has a nominal boron content that drops by less than 40% relative to the nominal value at all of the surfaces of the container. 1. A container for pharmaceutical and medical applications made from a borosilicate glass in the shape of a hollow body that is open on both of its ends , with a cylindrical portion having a wall thickness tolerance of maximally ±0.2 mm , wherein said borosilicate glass has a given nominal boron content , and wherein actual boron content of the container , at all its surfaces , drops by less than 40% relative to the nominal value.2. The container of claim 1 , wherein the container has a given nominal sodium content claim 1 , and wherein actual sodium content of the container claim 1 , at all its surfaces claim 1 , drops by less 20% claim 1 , relative to its nominal value.3. The container of claim 1 , having a flange on its one end and a cone area on its other end that has a diameter smaller than the diameter of the cylindrical area.4. The container of claim 1 , wherein the actual boron content of the container claim 1 , at all its surfaces claim 1 , drops by less than 20% relative to the nominal value.5. The container of claim 1 , having a total glass mass of maximally 15 g.6. The container of claim 2 , having a total glass mass of maximally 10 g.7. The container of claim 1 , having a total glass mass of maximally 5 g.8. The container of claim 1 , wherein said hollow body has the shape of a cylinder barrel made from a Type I borosilicate glass.9. The container of claim 1 , having a volume of maximally 15 ml.10. The container of claim 5 , having a volume of maximally 10 ml.11. The container of claim 5 , having a volume of maximally 5 ml.12. The container ...

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Номер записи: 91
22-08-2013 дата публикации

Drug Eluting Insert for Implantable Body

Номер: US20130218100A1
Автор: Adlon Katlin, Armbruster David, Chomyn Jeffrey, Yu Aaron
Принадлежит:

The present application discloses embodiments related to an implant and a method of forming an implant configured to treat a fractured bone. The implant can include a body having a proximal end, a distal end, and an outer surface extending from the proximal end to the distal end, wherein the body defines a central axis extending from the proximal end to the distal end; and a high tensile strand positioned adjacent the body such that at least a portion of the strand extends at least partially along the outer surface of the body in a direction substantially parallel with the central axis, and wherein the strand is loaded with an active agent. 1. An implant comprising:a body having a proximal end, a distal end, and an outer surface extending from the proximal end to the distal end, wherein the body defines a central axis extending from the proximal end to the distal end; anda high tensile strand positioned adjacent the body such that at least a portion of the strand extends at least partially along the outer surface of the body in a direction substantially parallel with the central axis, and wherein the strand is loaded with an active agent.2. The implant of claim 1 , wherein the body includes an inner surface that defines a cannula claim 1 , and wherein the cannula extends in a direction coaxial with the central axis along at least a portion of the implant claim 1 , and further wherein the strand is at least partially disposed within the cannula of the body.3. The implant of claim 2 , further comprising a cap that is received at least partially within the cannula when the body is implanted claim 2 , wherein the cap receives the strand near the distal end of the body.4. The implant of claim 3 , wherein the cap defines a longitudinal bore that is configured to receive a guidance member that aids in implantation of the implant.5. The implant of claim 3 , further comprising a ring member claim 3 , the ring member including an inner surface that defines a bore claim 3 , ...

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Номер записи: 92
22-08-2013 дата публикации

DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF

Номер: US20130218264A1
Автор: Blinn Stephen M., Kirkpatrick Sean R., Svrluga Richard C.
Принадлежит: EXOGENESIS CORPORATION

A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby. 1. A medical device having a surface adapted for delivering one or more drugs , comprising: and one or more drug coating layers on the surface of the device , at least one of the drug coating layers having at least one barrier layer adapted for controlling a rate of flow of material across the at least one barrier layer , and further wherein the at least one barrier layer consists of drug modified by Neutral Beam irradiation.2. The medical device of claim 1 , wherein the at least one barrier layer:controls a release rate of drugs;controls an elution rate of drugs; orcontrols an inward diffusion rate of a fluid into at least one of the one or more drug coating layers.3. The medical device of claim 1 , wherein at least one drug coating layer of the one or more drug coating layers contains a first quantity of a first drug claim 1 , said first drug overlaid by a first barrier layer comprising modified first drug claim 1 , said first barrier layer overlaid by a second quantity of a second drug claim 1 , said second drug overlaid by a second barrier layer comprising modified second drug.4. The medical device of claim 3 , wherein:the first drug and the second drug are the same drug or different drugs; andthe first barrier layer and the second barrier layer are constructed to control a temporal release profile of the first and second drugs.5. The medical device of claim 1 , wherein the controlled flow rate is:a drug elution rate;a drug release rate; ora fluid diffusion rate.6. The medical device of claim 1 , wherein the medical device is any of:a vascular stent;a coronary stent;an artificial joint ...

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Номер записи: 93
22-08-2013 дата публикации

Implant with a base body of a biocorrodible alloy

Номер: US20130218265A1
Автор: Andreas Ohl, Antje Quade, Baerbel Becher, Carsten Momma, Daniel Lootz, Karsten Schroeder
Принадлежит: BIOTRONIK VI PATENT AG

An implant having a base body, comprised either entirely or in part of a biocorrodible metallic material wherein at least the parts of the base body having the biocorrodible metallic material are at least partially covered with a coating of a crosslinked CF x layer that is nonpolymerized and has an F/C ratio in the range of 0.5 to 1.5.

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Номер записи: 94
29-08-2013 дата публикации

BIOABSORBABLE POLYMER COMPOSITIONS EXHIBITING ENHANCED CRYSTALLIZATION AND HYDROLYSIS RATES

Номер: US20130225538A1
Автор: Andjelic Sasa, FITZ Benjamin D.
Принадлежит: ETHICON, INC.

A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend. 1. A bimodal polymer composition , comprising:(a) a first amount of a fully amorphous bioabsorbable polymer having a first hydrolysis rate and a first molecular weight distribution; and(b) a second amount of said fully amorphous bioabsorbable polymer having a second hydrolysis rate and a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one;wherein a substantially homogeneous blend of said first and second amounts of said fully amorphous bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent, said substantially homogeneous blend having a hydrolysis rate greater than each of said first hydrolysis rate and said second hydrolysis rate.2. The bimodal polymer composition of claim 1 , wherein the bioabsorbable polymer is selected from the group consisting of poly(lactide) claim 1 , poly(glycolide) claim 1 , poly(dioxanone) claim 1 , poly(ε-caprolactone) claim ...

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Номер записи: 95
29-08-2013 дата публикации

Porous implant material

Номер: US20130226309A1
Автор: Komei Kato, Shinichi Ohmori, Yuzo Daigo
Принадлежит: Mitsubishi Materials Corp

Providing porous implant material having a strength property approximate to human bone, without arising stress shielding, and which is possible to maintain sufficient bound strength with human bone. Porous implant material has a porous metal body having a three-dimensional network structure formed from a continuous skeleton 2 in which a plurality of pores 3 are interconnected, wherein a porosity rate is 50% to 92%, the pores 3 are formed to have flat shapes which are long along a front surface and short along a direction orthogonal to the front surface, lengths Y of the pores 3 along the front surface are 1.2 times to 5 times of a length X orthogonal to the front surface, and a compressive strength compressing in the direction parallel to the front surface is 1.4 times to 5 times of a compressive strength compressing in the direction orthogonal to the front surface.

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Номер записи: 96
29-08-2013 дата публикации

Bioactive Scaffold for Therapeutic and Adhesion Prevention Applications

Номер: US20130226313A1
Автор: Brendan Harley, Eric Aiazian, Eric Soller
Принадлежит: Axle International Ltd

A device for inhibiting adhesion of apposing human body tissue layers includes a scaffold having a designated mean pore size, relative density, and degradation half-life. The scaffold may be operably positioned between apposing tissue layers, such as proximate adhesiogenic layers at a wound site, so as to permit remesothelialization of the tissue without formation of fibrous adhesions. The scaffold device of the invention inhibits adhesion formation by promoting contractile cell migration away from the wound site for a predetermined period of time. The invention further relates to device and methods for promoting internal tissue regeneration, and for provision and/or dispensation of therapeutic and/or diagnostic agents in vivo.

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Номер записи: 97
05-09-2013 дата публикации

Semi-Crystalline Composition For Coating

Номер: US20130230564A1
Автор: HOSSAINY Syed Faiyaz Ahmed, Kleiner Lothar W., Lim Florencia, Ngo Michael Huy, Tang Yiwen, Trollsas O. Mikael
Принадлежит: Abbott Cardiovascular Systems Inc.

The present invention provides a coating comprising a semi-crystalline polymer on an implantable device and methods of making and using the same. 1. An implantable device comprising a coating that comprises a semi-crystalline polymer , the semi-crystalline polymer being selected from the group consisting of poly(L-lactic acid-co-glycolic acid) of an 82:18 L-lactic acid:glycolic acid molar ratio , poly(D-lactic acid-co-caprolactone) (PDLA-CL) , poly(D-lactic acid-co-glycolic acid) (PDLA-GA) , poly(D-lactic acid-co-glycolide-co-caprolactone) (PDLA-GA-CL) , poly(D-lactic acid-co-caprolactone) (PDLA-CL) , poly(thioesters) , semi-crystalline poly(ester amide) (PEA) polymers , and combinations thereof.2. The implantable device of claim 1 , wherein the semi-crystalline polymer comprises poly(L-lactic acid-co-glycolic acid) of an 82:18 L-lactic acid:glycolic acid molar ratio.3. The implantable device of claim 1 , wherein the semi-crystalline polymer is poly(L-lactic acid-co-glycolic acid) of an 82:18 L-lactic acid:glycolic acid molar ratio.4. The implantable device of claim 1 , wherein the semi-crystalline polymer is a semi-crystalline poly(ester amide) (PEA) polymer.5. The implantable device of claim 1 , wherein the coating further comprises a bioactive agent.6. The implantable device of claim 5 , wherein the bioactive agent is selected from the group consisting of paclitaxel claim 5 , docetaxel claim 5 , estradiol claim 5 , 17-beta-estradiol claim 5 , nitric oxide donors claim 5 , super oxide dismutases claim 5 , 4-amino-2 claim 5 ,2 claim 5 ,6 claim 5 ,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO) claim 5 , biolimus claim 5 , tacrolimus claim 5 , dexamethasone claim 5 , rapamycin claim 5 , everolimus claim 5 , 40-O-(3-hydroxy)propyl-rapamycin claim 5 , 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin claim 5 , 40-O-tetrazole-rapamycin claim 5 , 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578) claim 5 , γ-hiridun claim 5 , clobetasol claim 5 , pimecrolimus claim 5 , imatinib mesylate ...

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Номер записи: 98
05-09-2013 дата публикации

MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE

Номер: US20130230571A1
Автор: Bhat Vinayak, Yan John, Zheng Xiaoxia
Принадлежит: Elixir Medical Corporation

The present disclosure provides a device for intracorporeal use which comprises an implant or a temporary device and at least one source of myolimus or a derivative thereof. The present disclosure also provides a method of inhibiting cell proliferation, inflammation or cytokine production by systemic or local administration of a therapeutically effective amount of myolimus or a derivative thereof. Further included in the present disclosure is a method of treating an ophthalmic condition or disease by administering a therapeutically effective amount of myolimus or a derivative thereof. 2. The medical device of claim 1 , wherein the medical device is configured to release the macrocyclic lactone to a lumen or organ of a mammalian body to inhibit cell proliferation claim 1 , inflammation or cytokine production.3. The medical device of claim 2 , wherein the medical device is configured to release the macrocyclic lactone to a lumen or organ of a mammalian body to inhibit smooth muscle cell proliferation and inflammation.4. The medical device of claim 1 , wherein the implant is a luminal prosthesis.5. The medical device of claim 4 , wherein the luminal prosthesis comprises an expandable scaffold.6. The medical device of claim 4 , wherein the luminal prosthesis comprises a stent or a graft.7. The medical device of claim 6 , wherein the luminal prosthesis is a vascular stent.8. The medical device of claim 7 , wherein the stent is substantially fully degradable.9. The medical device of claim 7 , wherein the stent is balloon expandable.10. The medical device of claim 4 , wherein the luminal prosthesis has a luminal surface and a tissue-facing surface claim 4 , and wherein the macrocyclic lactone is associated with at least one of the luminal and tissue-facing surfaces.11. The medical device of claim 1 , wherein at least 75% of the macrocyclic lactone is released from the medical device in a period from about 1 day to about 2 years.12. The medical device of claim 1 , wherein ...

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Номер записи: 99
05-09-2013 дата публикации

Biocompatible surfaces and devices incorporating such surfaces

Номер: US20130231733A1
Автор: Jason J. Strid, Keith A. Knisley, Michael J. Vonesh, Paul A. Silvagni, Rachel Radspinner, Vishnu T. Marla
Принадлежит: WL Gore and Associates Inc

The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.

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Номер записи: 100