СПОСОБ АМИНИРОВАНИЯ

Изобретение относится к способу аминирования для производства полиаминов, например аминирования спиртов, фенолов, диолов, алканоламинов и алкиленоксидов аммиаком, или первичными, или вторичными аминами, предпочтительно аминирования бифункциональных соединений, например моноэтаноламина, аммиаком в присутствии каталитически эффективного количества катализатора дегидрирования/гидрирования. согласно которому процесс проводят на первом этапе до степени конверсии 50-9 мас.% в расчете на общий выход полиаминов при средневзвешенной пропорционально времени температуре, которая по меньшей мере на 15oС выше, чем средневзвешенная пропорционально времени температура во время реакции, проходящей на последующем этапе процесса. Предпочтительно температура на первом этапе на 25-100oС выше, чем температура на последующем этапе процесса. В частности, температура на первом этапе составляет 160-300oС, а температура на последующем этапе составляет 100-190o C. В качестве катализатора дегидрирования/гидрирования ...

СПОСОБ ПОЛУЧЕНИЯ МЕТИЛИРОВАННЫХ ТРЕТИЧНЫХ АМИНОВ

Изобретение относится к новому способу получения метилированных третичных амино, который заключается в осуществлении реакции гексаметилентетрамина с различными азотированными предшественниками в присутствии водорода и катализатора гидрирования. Реакция очень селективная, метилирование производят только на азотах аминов и нитрилов. Способ позволяют легко получать метилированные амины, соответствующие начальным производным, таким как жирные моно- или полиамины, аминоспирты, эфирамины, нитрилы, аминонитрилы и т.д. 14 з.п. ф-лы.

СПОСОБ СТЕРЕОСЕЛЕКТИВНОГО СИНТЕЗА ХИРАЛЬНЫХ АМИНОВ

Изобретение касается способа стереоселективного синтеза одной хиральной формы амина в количестве, существенно превосходящем другую форму, путем воздействия на кетон ферментом омега-аминокислотной трансаминазой в присутствии донора аминогруппы. Донор аминогруппы используют в значительном молярном избытке. Кетон и донор аминогруппы приводят во взаимодействие с целыми клетками микроорганизма, которые продуцируют омега-аминокислотную трансаминазу, или с водным раствором фермента, или с ферментом, иммобилизованным на носителе. Способ может использоваться в химических технологиях при производстве фармацевтических и агрохимических препаратов. 5 з.п. ф-лы, 1 табл.

ВЫДЕЛЕНИЕ АМИНОВ ИЗ ЭМУЛЬСИЙ

... 1. Способ выделения поверхностно-активных аминов из эмульсии, содержащей соль амина и нафтеновой кислоты, включающий (а) контактирование эмульсионного слоя или фазы, содержащей соль поверхностно-активного амина с кислотой, выбранной из группы, включающей минеральные кислоты, или с диоксидом углерода в количествах и при условиях, достаточных для получения соли амина и указанной минеральной кислоты или бикарбоната амина, причем указанную соль поверхностно-активного амина получают путем эмульсионного фракционирования с указанным поверхностно-активным амином, (б) разделение верхнего слоя и нижнего водного слоя; (в) добавление к нижнему водному слою неорганического основания, если на операции (а) применяют минеральную кислоту, или нагревание до необходимой температуры и в течение необходимого времени, если на операции (а) применяют диоксид углерода, чтобы довести рН водного слоя до значений больших или равных 8; (г) продувание газа через указанный водный слой для получения пены, содержащей указанный ...

СПОСОБ ПОЛУЧЕНИЯ 2,4,6-ТРИМЕТИЛ-(1,3,5-ДИТИАЗИНАН-5-ИЛ)АМИНА

Способ получения 2,4,6-триметил-(1,3,5-дитиазинан-5-ил)-амина ! , ! заключающийся во взаимодействии предварительно перемешанной при температуре 0°С в течение 15 мин смеси гидразингидрата (60%) и уксусного альдегида с сероводородом до достижения мольного соотношения реагентов гидразин: уксусный альдегид: сероводород = 1:4:2 и последующем перемешивании реакционной массы в течение 1 ч при 0°С.

СПОСОБ ПОЛУЧЕНИЯ СТРУКТУРИРОВАННОГО СТРУКТУРООБРАЗУЮЩЕГО АГЕНТА

Катализатор для гидрирования нитросоединений

Изобретение касается каталитической химии, в частности катализатора для гидрирования нитросоединений, и может быть использовано в производстве химических веществ. Цель - повышение активности катализатора. Для этого используют состав, включающий, мас.%: никель 30-42 железо 1-3 молибден 5-10 олово или ниобий 5-10 алюминий до 100. в этом случае при гидрировании, например, динитротолуола количество поглощенного водорода увеличивается с 60 до 76 мл/мин на 1 г указанного состава сплава, причем падение активности после 8-кратного гидрирования падает в меньшей степени, чем в известном случае. 1 табл.

Способ крашения или печатания целлюлозосодержащих материалов

I. СПОСОБ КРАКШН1Ш ИЛИ ПЕЧАТАНИЯ ЦЕЛЛЮЛОЗОСОДЕРХШЦИХ МАТЕРИАЛОВ анионными красителями с применением высокотемпературной фиксации, отличающийся тем, что, перед крашением или печатанием, или в процессе него материал обрабатьшают четвертичным аммониевым соединением общей формулы I rtY-CHf-CHrK- R где X - анион неорганической или органической кислоты; Y атом галогена; 1-3; n К,и R водород, С -С -алкип, шш С -С -гидроксиалкил; R 2 С- -алкил или Cj Cjvj гидроксиалкил , С -С -алкиларил , или или Спарил , и веществом, отщеплякнцим аммиак в процессе фиксации при i80-230 С, 2. Способ по п. Г, отличающийся тем, что в качестве вещества , отщепляющего аммиак, используют гeкca eтилeнтeтpaмин или карбонат аммония. О эо о :л ...

Способ получения производных 2-аминобензиламина

Способ получения производных бензиламина или их солей

Способ очистки динитроанилинов от нитрозаминов

Способ подавления биозагрязнения водной системы

Изобретение относится к обработке воды , может быть использовано при подавлении биозагрязнения в различных водных системах и позволяет повысить эффективность процесса В водную систему вводят полигалоген ид тетраалкиламмония, содержащий в своей молекуле галогенид (хлор бром или йод), а в качестве радикалов - алкил, простои алкиловый эфир, циклический алкил, оксиэтил, полиэфир, галогенза- мещенный алкил, причем не более чем один из заместителей является водородом и по крайней мере един из заместителей содержит не менее 8 атомов углерода. Для повы- шения эффективности действия полигалогенидов их смешивают с поверхностно-активным веществом, выбранным из ряда: блок-сополимер полиоксиэтилен-по- лиоксипропилена, этоксилированный ал- килфенол, сложный этоксилированный эфир фосфорной кислоты, сложный эфир гликоля, соль алкилполиоксиэтиленаммо- ния, или их смесью. Введение полигалоге- нида в количестве 0,12-65,9 мг/л или смеси в количестве 0 24-179,7 мг/л позволяет полностью подавить развитие бактерий ...

Способ получения многоядерных ароматических полиаминов

Способ получения производных пинана в виде оптически активных изомеров

Способ получения пиридиловых или фениловых соединений,или их гидрохлоридов,или сложных эфиров

Изобретение относится к гетероциклическим соединениям, в частности к способу получения пиридиповых или фениловых соединений общей формулы ...

Способ получения гидрохлорида N,N-диметил-1- @ 1-(4-хлорфенил)-циклобутил @ -3-метилбутиламина в виде моногидрата

Изобретение касается аминов, в частности способа получения гидрохлорида Н,Н-диметил-1 1-(4-хлорфенил)- циклобутил -3-метилбутиламина в виде моногидрата, который может быть использован при получении фармацевтического препарата. Цель - получе1ше 1егигроскопичного продукта. Процесс ведут суспендированием гидрохлорида N,N-диметил-1 - f1-(4-хлорфенил)-цик- лобутил -3-метилбутш1амина в воде или перекристаллизацией из воды или смеси воды и несмешивающегося или смешивающегося с водой растворителя. Причем в качестве несмешивающегося с водой растворителя желательно использовать толуол, ксилол или цик- логексан, а в качестве смешивающего- ся - ацетон, пропан-2-ол, промыпшен- ньш метилированный спирт, 2-этокси- этанол, 1,2-диметоксиэтан, тетраг щ- рофуран, 1,4-диоксан или метилацетат. Способ позволяет получать продуктf который при воздействии атмосферы в течение 5 мес не поглощает влагу 2 3. п. ф-лы.

Способ получения смеси хлоранилинов

Способ получения производных сульфонилмочевины или ее основных солей

Способ получения замещенных дибензоциклогептенов

Способ получения римантадина

A low temperature and pressure process for preparing rimantadine in high yields from 1-adamantyl methyl ketoxime is provided. The process comprises contacting a solution of the ketoxime with hydrogen in the presence of a platinum on carbon catalyst at a low temperature and pressure, e.g., room temperature and a pressure of about 25-115 psia (170-790 KPa) are preferred.

Способ получения ароматических вторичных или третичных аминосоединений

Способ получения замещенных 2,6-динитробензоламинов

Способ получения полиаминов с первичными аминогруппами

Изобретение касается производства первичных аминов ,в частности, получения полиаминов, используемых в синтезе полиуретанов. Процесс ведут гидролизом имеющих изоцианатные группы (в количестве 1,8-26 мас.%) соединений водой в среде растворителя-диметила-цетамида или диметилформамида (массовое соотношение к воде 1,5-44):1, при 45-150°С в присутствии основного катализатора и сохранения гомогенности реакционной фазы. Эти условия упрощают процесс за счет определенного соотношения воды и растворителя и меньшего расхода катализатора.

Способ получения пиридиловых соединений или их солей, или сложных эфиров, или амидов

Изобретение касается гетероциклических соединений, в частности получения пиридиловых соединений общей формулы CH=CH-CH=C-(R1C(O)OH)-N=C-CA-(C6H4-пара-R2)-CHB-CH2-N-(CH2)N+2, где R1- -CH=CH- или -CH2-CH2- R2-C1-C4-алкил A и B - каждый в отдельности H или AC-CB означает C=C N=1-3, или их солей, или, когда R1-группа -CH=CH-, а AC-CB-группа -C=C-, их сложных эфиров или амидов, проявляющих антигистаминную активность, что может быть использовано в медицине. Цель - создание новых более активных соединений указанного класса. Синтез ведут дегидратацией соединения формулы: CH=CH-CH=C(CH=CH-C(O)OR3)-N=C-C(OH) (C6H4-пара-R2)-CH2-CH2-N-(CH2)N+2, где R2и N - См. выше R3-C1-C4-алкил. Полученное соединение, где AC-CB-группа -C=C-, в случае необходимости гидрируют с получением соединения, где AC-CB-группа -CH=CH- и R1-группа -CH2-CH2-. Целевой продукт выделяют в виде свободной кислоты или соли, или, когда AC-CB - группа -C=C- и R1-группа -CH=CH-, в виде сложного эфира или амида. Новые соединения по антигистаминной ...

Способ получения амина или его солей

Способ получения сульфонатов или гидрохлоридов динитрила аминомалоновой кислоты

Изобретение касается замещенных аминокислот, в частности получения сульфонатов или гидрохлоридов динитрила аминомалоновой кислоты, применяемых в органическом синтезе. Цель - повышение выхода целевого продукта. Его синтез ведут нитрозированием динитрила малоновой кислоты нитритом натрия в среде смеси 15 - 30 моль воды и 0,02 - 0,05 моль серной кислоты (в расчете на 1 моль динитрила малоновой кислоты) при PH 3,8 - 4,2 и комнатной температуре. Затем продукты нитрозирования, содержащие динитрил оксиаминомалоновой кислоты , подвергают экстракции с этилацетатом, экстракт гидрируют при 10 - 60°С в присутствии PT/C в смеси уксусной кислоты с этилацетатом при ее молярном соотношении с этилацетатом (2-15):1 и давлении 1-40 ат. После гидрирования продукт отфильтровывают от катализатора и ведут осаждение целевого продукта обработкой соответствующей кислотой. Эти условия повышают выход целевого продукта с 27 - 49% до 63 - 88,5%. 1 з.п. ф-лы, 2 табл.

Способ получения производных 1,1-бифенил-2-илалкиламина или их солей

Способ получения производных 1,1-Оифенил-2-илалкиламина общей формулы RI 1Н2- 5Нг-йн-сн2- С он 2 где RI - водород или С -С алкил; R2-C,-C4- алкил, или их солей, отличающийся тем, что 1,2,-эпокск-4-{1,1-бифенил2-ил )-бутан вводят во взаимодействие с амином общей формула ,RI НИ; СО где RJ и R2 имеют указанные значения, при нагревании в органическом растворителе , таком как этанол, и выде- S ляют целевой продукт в свободном виде или в виде соли.

Способ получения смеси ди-/аминофенил/-метанов и олигомерных полиметиленполифенилполиаминов

... 1. СПОСОБ ПОЛУЧЕНИЯ СМЕСИ ДИ-(АМИНОФЕНИЛ)-МЕТАНОВ И ОЛНГОМЕРНЫХ ПОЛИМЕТНЛЕНПОЛИФЕНИЛПОЛИАМИНОВ, В которой содержание диамина находится в интервале между 40 и 60 вес.%, взаимодействием анилина и формальдегида с использованием кислотных ка-, тализаторов, отлича-ющийс я тем, что, с целью.повышения качества целевого продукта, анилин подвергс1ют взаимодействию с формальдегидом в мольном соотношении 4-10:1 при 20-60с с образованием смеси аминалов, отделением воды и контактированием аминалов с катализаторомдиатомовой землей, глиной или цеолитом в количестве 1-10% от веса реагирующих веществ, полученн ые бензиламины пере.гоняют при пониженном давлении при 51-150 С до достижения содержания анилина в остатке 3-22%, полученный остаток нагревают при 100-190 (в присутствии катализатора - диатомовой земли, глины или цеолита. 2.Способ поп. 1, отлича ю щ и и с я тем, что, в качестве катализатора используют глину аттапульгит . 3.Способ по п.. 1, о т л и ч аю щ и и с я тем, что мольное соотношение анилина ...

Способ получения фениламиноалканов

Mit Aminogruppen beschichtete Oberfläche

FAERBEREIHILFSMITTEL

VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN AROMATISCHEN AMINEN

Verfahren zur Herstellung von Beta-Nitro-Enaminen und deren Zwischenprodukten

VERFAHREN ZUR HERSTELLUNG VON 3(4),8(9)-BIS-(AMINOMETHYL)-TRICYCLO (5.2.1.0(PFEIL HOCH)2(PFEIL HOCH)(PFEIL HOCH),(PFEIL HOCH)(PFEIL HOCH)6(PFEIL HOCH))-DECAN

SORBINAL BY OPTICAL RESOLUTION OF PRECURSOR 6-FLURO-4-UREIDOCHROMAN-4-CARBOXYLIC ACID

VERFAHREN ZUR HERSTELLUNG EINES GEMISCHES AUS DI(AMINOPHENYL)METHAN UND OLIGOMEREN POLYMETHYLENPOLYPHENYLPOLYAMINEN

VERFAHREN ZUR HYDRIERUNG VON AROMATISCHEN DINITRILEN

VERFAHREN ZUR HERSTELLUNG EINES GEMISCHS AUS DI(AMINOPHENYL)METHAN UND OLIGOMEREN POLYMETHYLENPOLYPHENYLPOLYAMINEN

2,2-DIFLUORCYCLOPROPYL-DERIVATE.

VERFAHREN ZUR HERSTELLUNG VON DIAMINEN DER DIPHENYLMETHANREIHE

VERFAHREN ZUM REINIGEN ORGANISCHER SUBSTANZEN

VERFAHREN ZUR REINIGUNG VON NITROSAMINE ENTHALTENDEN DINITROANILINEN

DECAPRENYLAMINDERIVATE

Alpha,Alpha disubstituierte N-Cycloalkylalkyl-Benzylamine, Verfahren zu ihrer Herstellung, ihre Anwendung als Arzneimittel und ihre Zwischenprodukte bei der Herstellung.

GEM-DIHALO-1,8-DIAMINO-4-AZA-OKTANE.

NEUE STABILISATOREN UND DEREN VERWENDUNG ZUR HERSTELLUNG STABILISIERTER POLYAMIDE UND KAUTSCHUKMATERIALIEN

Flüssigkristall-Cyclohexylbenzenderivate, Herstellung derselben und neue nematische Mischungen die sie enthalten.

VERFAHREN ZUR HERSTELLUNG VON 4-NITRODIPHENYLAMINEN

VERFAHREN ZUR HERSTELLUNG VON DIALKYLAMINOETHYLAMINEN

FUNGIZIDE CYCLOHEXYLAMINE.

TRIFLUORMETHYLGRUPPEN ENTHALTENDE CYOLOPROPYLAMINE

SUBSTITUIERTE P,P'-METHYLEN-BIS-ANILINE.

VERFAHREN ZUR BEHANDLUNG VON QUATERNAEREN ONIUMSALZEN UND DESSEN VERWENDUNG BEI DER HERSTELLUNG VON HEXAFLUORPROPYLENOXID.

Verbindungen und Immunoassay für tricyclische Antidepressiva.

VERFAHREN ZUR HERSTELLUNG SEKUNDAERER ALIPHATISCHER AMINE

CHLORIERTE AROMATISCHE AMINE

AMINIERUNGSVERFAHREN

VERFAHREN ZUR REINIGUNG VON TERTIAEREN AMINEN

TRANS-3-(4'-TERT.-BUTYLCYCLOHEXYL-1')-2-METHYL-1-DIALKYL-AMINOPROPANE, IHRE HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL

PRODUCTION OF CYCLOHEXYLAMINE

VERFAHREN ZUR HERSTELLUNG VON 3-ECKIGE KLAMMER AUF N'-(3-HALOGENPROPYL)-N'-METHYLAMINO ECKIGE KLAMMER ZU-N,N,N-TRIMETHYL-1-PROPANAMINIUMHALOGENIDEN

CRYSTALLINE POLYAMIDE, ITS APPLICATION AND DIAMINES

ISOPROPYLBENZOLDERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG

POLYHALOGENATED AROMATIC COMPOUNDS

PROCESS FOR THE CLEAVAGE OF PHTHALIMIDES

VERFAHREN ZUR SELEKTIVEN HYDRIERUNG UNGESAETTIGTER VERBINDUNGEN

VERFAHREN ZUR HERSTELLUNG VON STYROLIERTEM DIPHENYLAMIN

VERFAHREN ZUR KATALYTISCHEN ISOMERISIERUNG EINES CYCLOHEXAN-BIS-(METHYLAMINS)

VERFAHREN ZUR PARTIELLEN REDUKTION VON POLYNITRIERTEN DIARYLVERBINDUNGEN

VERFAHREN ZUR HERSTELLUNG EINES MONOMEREN FUER EIN ALS GALLENSAEURE- SEQUESTRIERMITTEL GEEIGNETES POLYMER

VERFAHREN ZUR HERSTELLUNG VON AMINOVERBINDUNGEN AUS HYDROXYLVERBINDUNGEN

A process for the production of amino compounds from hydroxyl compounds (Voelter reaction), according to which a hydroxyl compound is converted with trifluormethanesulphonic acid anhydride in water-free conditions, the corresponding triflate derivative is converted, in water-free conditions, with ammonia or an amine in an organic solvent and the amino compound obtained (formula I) is isolated.

VERFAHREN ZUR HERSTELLUNG VON AMINEN

VERFAHREN UND MITTEL ZUM PRAEPARIEREN VON FASERN

VERFAHREN ZUR HERSTELLUNG AROMATISCHER AMINE

PROCESS FOR THE PREPARATION OF METHYLENE BRIDGED POLYARYLAMINES

... 1378423 Methylene bridged polyarylamines IMPERIAL CHEMICAL INDUSTRIES Ltd 27 Dec 1972 [28 Jan 1972] 4045/72 Heading C2C In a process for the manufacture of methylene bridged polyarylamines by reaction of formaldehyde and a primary arylamine in the presence of a catalyst, the formaldehyde is added to the other components in a first mixing stage while continuously circulating the contents of the reaction vessel through an externally situated heat exchanger to apply cooling before isomerization occurs. The preferred catalyst is hydrochloric acid and the preferred primary arylamine is aniline.

1-AMINOMETHYLACE-NAPHTHENES AND THEIR PRODUCTION

PROCESS FOR THE PRODUCTION OF HALOGENATED AROMATIC AMINES

... 1419751 Halogenated aromatic primary amines NIPPON KAYAKU KK 3 Sept 1974 [6 Sept 1973] 38553/74 Heading C2C Halogenated aromatic primary amines are prepared by hydrogenating halogenated aromatic nitro compounds in the presence of Raney nickel and dicyandiamide, cyanamide or calcium cyanamide, in an inert solvent at from 40‹ to 150‹ C. at elevated hydrogen pressure. Specified amines are chloro- and bromo-anilines, dichloro- and trichloro-anilines, dichlorodiaminobenzenes, chlorotoluidines,diaminochlorobenzenes,chloromethoxyanilines and chloroaminophenols.

AMINATION OF AROMATIC COMPOUNDS

... 1449395 Amination of aromatic compounds E I DU PONT DE NEMOURS & CO 18 Dec 1974 [19 Dec 1973] 54654/74 Heading C2C Aromatic compounds are aminated by reacting ammonia with an aromatic compound miscible with ammonia of an elevated temperature and at a superatmospheric pressure in the presence of a conditioned cataloreactant which has been treated with ammonia prior to the amination reaction, the cataloreactant being a nickel/nickel oxide/zirconium oxide composition which has been conditioned by a process comprising partial reduction followed by partial oxidation. The cataloreactant may additionally comprise an oxide or carbonate of strontium, barium, calcium, magnesium, zinc, iron, titanium, aluminium, silicon, cerium, thorium, uranium or an alkali metal.

METHOD OF RACEMIZATION OF OPTICALLY ACTIVE AMINES

... 1306412 Racemizing ,#-diphenylethylamines SUMITOMO CHEMICAL CO Ltd 15 May 1970 [20 May 1969] 23591/70 Heading C2C A method of racemizing an optically active ,#-diphenylethylamine of the formula wherein R 1 and R 2 are independently C 1 -C 4 alkyl groups and m and n are independently 0, 1, 2, 3, 4 or 5 includes heating an optically active said compound at between 100‹ C. and its boiling point in an inert gas and in the presence of a catalyst for a reduction reaction. Catalysts employed in examples include Raney nickel and palladium charcoal.

PHOTOCONDUCTIVE COMPOSITIONS

... 1309483 N,N-Dialkylaminoalkanes EASTMAN KODAK CO 1 Oct 1970 [1 Oct 1969] 46811/70 Heading C2C [Also in Division H1] Bis - (N,N - dialkylaminoaryl)dialkylmethanes or gem - bis - (N,N - dialkylaminoaryl)- cycloalkanes are made by condensing a ketone with a N,N-dialkylaniline. In the embodiments dialkyl is dimethyl, diethyl or methyl ethyl; dialkylmethane is propane, butane or heptane; and cycloalkane is cyclopentane, cycloheptane, cyclohexane optionally substituted by methyl, dimethyl, methylpropyl or tetramethylbutyl, bicyclohexane or norborane. The compounds 1,3,3 - tris(4 - N,N - diethylaminophenyl)butane, 2[4,4 - bis - (4 - N,N - diethylaminophenyl)- cyclohexyl] - 2 - cyclohexylpropane and 2,2- bis[4,4 - bis - (p - N,N - diethylaminophenyl)- cyclohexyl]propane are prepared.

2-AMINOINDANE DERIVATIVES

PROCESS FOR THE PREPARATION OF TERTIARY AMINES

PROCESS FOR THE MANUFACTURE 'F DI- AND TRIAMINO NAPHTHALENES

... 1460409 Di- and tri-amino naphthalenes BAYER AG 24 July 1975 [10 Aug 1974 2 Nov 1974] 30989/75 Heading C2C Compounds of the formula wherein R1 is hydrogen or amino, are prepared by treating a compound of the formula where R2 is hydrogen or nitro, with hydrogen in the presence of a hydrogenation catalyst and a solvent of the formula wherein R3 is hydrogen, halogen or alkyl; R4 is hydrogen, halogen, alkyl, hydroxy, alkoxy, amino or mono- or di-alkyl amino; R5 is hydrogen, chlorine, alkyl, hydroxy, alkoxy, amino or mono- or di-alkylamino, and R6 and R7, which may be the same or different, are hydrogen or alkyl or together form a -(CH 2 ) 4 - group optionally substituted by one or more methyl and/or ethyl groups. The catalyst is preferably a metal of Group VIII of the Periodic Table.

Preparation of nitrodiarylamines

... 1,136,026. Nitrodiarylamines. UNIVERSAL OIL PRODUCTS CO. 15 March, 1966 [22 March, 1965], No. 11227/66. Heading C2C. The invention relates to a process for the preparation of a nitro-diarylamine which comprises reacting a halonitroaromatic compound e.g. a chloronitrobenzene with an aromatic amine e.g. aniline at a temperature of from about 150‹ C. to about 300‹C. in the presence of an oxide of Group II of a period table e.g. calcium or magnesium while maintaining substantially anhydrous reaction conditions. Examples are given of the preparation of onitrodiphenylamine. Many halonitroaromatic and aromatic amine compounds are listed.

Novel Tricyclic Amines and a Process for the Manufacture Thereof

... 1,182,639. Dibenzo[a,d]cycloheptene derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 7 Nov., 1967 [8 Nov., 1966; 2 Feb., 1967], No. 50467/67. Heading C2C. Novel dibenzo[a,d]cycloheptene derivatives of the general formula wherein R is a chlorine or fluorine atom, R1 is a methyl group, R2 and R3 are each a chlorine or fluorine atom and X is an ethylene group or a vinylene group which may be substituted by a halogen atom and the broken lines denote optional bonds, and acid addition salts thereof are prepared (i) by reduction or dehydration of a hydroxy compound of the general formula wherein one of Y1 and Y2 is a hydrogen atom and the other is a hydroxy group; (ii) reaction of a 5-halo-substituted dibenzo[a,d]cycloheptene of the general formula wherein W is a halogen atom, with a dimethylaminopropyl magnesium halide; or (iii) by treatment of a 5-substituted dibenzo[a,d]cycloheptene of the general formula wherein Z is a halogen atom or a substituted ...

PREPARATION OF DIPHENYLAMINES

PRODUCTION OF AN AROMATIC MONOAMINE AND AN AROMATIC DIAMINE

Pro-drug Compounds

A compound of formula (I), or a pharmaceutically acceptable salt thereof: 2. A compound according to wherein A is a direct bond claim 1 , or —C(R)(R)O*—.3. A compound according to wherein Rand Rare both H claim 1 , or Rand Rare both Calkyl claim 1 , or Ris H and Ris Calkyl.4. A compound according to wherein Ris H and Ris methyl claim 1 , ethyl or isopropyl.6. A compound according wherein Zis Cl claim 1 , Zis F claim 1 , and Zis H; or Zis Cl claim 1 , Zand Zare H; or Zis H claim 1 , Zis F claim 1 , and Zis H; or Zis F claim 1 , Zis H claim 1 , and Zis F.7. A compound according to wherein the compound of formula (I) is selected from:{[(3S,4S)-6-Acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}phosphonic acid,(3S,4S)-6-Acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl 2-(dimethylamino)acetate hydrochloride,(3S,4S)-6-Acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl acetate,{[(3S,4S)-6-Acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl acetate,{[(3S,4S)-6-Acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methyl 2-(dimethylamino)acetate,(3S,4S)-6-Acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl 2-aminoacetate hydrochloride,(3S,4S)-6-acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl 2-(methylamino)acetate hydrochloride, or({[(3S,4S)-6-Acetyl-4-[(3-chloro-4-fluorobenzene)amido]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}methoxy)phosphonic acid diamineand a pharmaceutically acceptable salt thereof.8. A pharmaceutical composition comprising a compound as claimed in claim 1 , together with one or more pharmaceutically acceptable carriers and/or excipients.9. (canceled)10. (canceled)11. A method of treatment of a disease or medical condition which benefits from inhibition of gap ...

METHOD FOR PURIFYING 1,5-PENTANEDIAMINE AND THE 1,5-PENTANEDIAMINE PREPARED THEREBY

Provided is a method for purifying 1,5-pentanediamine comprising: providing 1,5-pentanediamine to be purified and treating the 1,5-pentanediamine to be purified by a reduction reaction to obtain purified 1,5-pentanediamine. Meanwhile, further provided is 1,5-pentanediamine prepared by the method. The purification method has a concise process and a simple operation, and is suitable for industrial production, and can significantly improve the quality of 1,5-pentanediamine. 1. A method for purifiying 1 ,5-pentanediamine , comprising:providing a mixture containing 1,5-pentanediamine to be purified and 2,3,4,5-tetrahydropyridine; andtreating the mixture by use of a reduction reaction to reduce the 2,3,4,5-tetrahydropyridine to piperidine thereby obtaining a first purified 1,5-pentanediamine composition,wherein a reducing agent is used in the reduction reaction and the reducing agent is metal hydride.2. The method according to claim 1 , wherein the content of 2 claim 1 ,3 claim 1 ,4 claim 1 ,5-tetrahydropyridine impurity in the first purified 1 claim 1 ,5-pentanediamine composition is less than 0.05 wt %.3. The method according to claim 1 , wherein the content of 2 claim 1 ,3 claim 1 ,4 claim 1 ,5-tetrahydropyridine impurity in the first purified 1 claim 1 ,5-pentanediamine composition is less than 0.03 wt %.4. The method according to claim 1 , further comprising a distillation step to remove the piperidine from the first purified 1 claim 1 ,5-pentanediamine composition to obtain a second purified 1 claim 1 ,5-pentanediamine composition claim 1 , so that the content of piperidine in the second purified 1 claim 1 ,5-pentanediamine composition is less than 0.05 wt % claim 1 , based on the weight of 1 claim 1 ,5-pentanediamine in the mixture.5. The method according to claim 4 , wherein the content of piperidine in the second purified 1 claim 4 ,5-pentanediamine composition is less than 0.03 wt %.6. The method according to claim 1 , wherein the metal hydride is selected from ...

METHOD OF MAKING A TEMPLATING AGENT

A method for preparing 1-adamantyltrimethylammonium methylcarbonate or N,N-dimethyl-3,5-dimethylpiperidinium methylcarbonate is disclosed. The method comprises reacting dimethyl carbonate and 3,5-dimethylpiperidine or a 1-adamantylamine compound and in the presence of water in a sealed vessel at a temperature of from 80 to 200° C. The 1-adamantylamine compound is 1-adamantylamine, 1-adamantylmethylamine, or mixtures thereof. 1. A method for preparing 1-adamantyltrimethylammonium methylcarbonate , comprising reacting 1-adamantylamine compound in the presence of water in a sealed vessel at a temperature of from 80 to 200° C. , wherein the 1-adamantylamine compound is selected from the group consisting of 1-adamantylamine , 1-adamantylmethylamine , and mixtures thereof.2. The method of wherein the molar ratio of dimethyl carbonate: the 1-adamantylamine compound or is in the range of 5 to 20.3. The method of wherein the molar ratio of dimethyl carbonate:the 1-adamantylamine compound or 3,5 dimethylpiperidino is in the range of 8 to 14.4. The method of wherein the molar ratio of water: the 1-adamantylamine compound is in the range of 1 to 4.5. The method of wherein the reaction of the 1-adamantylamine compound with dimethyl carbonate is performed at a temperature in the range of 120-160° C.6. The method of wherein the 1-adamantylamine compound is 1-adamantylamine.7. The method of further comprising reacting the 1-adamantyltrimethylammonium methylcarbonate with calcium hydroxide in the presence of a water to produce 1-adamantyltrimethylammonium hydroxide.8. The method of wherein the molar ratio of calcium hydroxide: 1-adamantyltrimethylammonium methylcarbonate is in the range of 1.05 to 1.75.9. The method of wherein the reaction of 1-adamantyltrimethylammonium methylcarbonate with calcium hydroxide in the presence of water is performed at reflux.10. (canceled)11. (canceled) The invention relates to a method for preparing 1-adamantyltrimethyl-ammonium methylcarbonate and N ...

NOVEL PICOLINAMIDE-CINCHONA ORGANOCATALYSTS AND DERIVATIVES

The present application describes a novel type of picolinamide-cinchona organocatalyst that allows for the successful transformation of ketimines to chiral amines with very high enantioselectivities and with the highest TOFs reported for any particular organocatalyst to date. These organocatalysts have also been immobilized to a variety of solid supports, including magneto-nanoparticles. 2. The organocatalyst according to claim 1 , wherein the pyridyl ring is fused with another benzene unit.3. The organocatalyst according to any one of the previous claims claim 1 , wherein said organocatalyst is immobilized with a suitable linker to a suitable support.4. The organocatalyst according to the previous claim 3 , wherein the linker is selected from the group comprising an alkyl claim 3 , a polyoxyalkyl or a polyalkylsulfide chain.5. The organocatalyst according to any one of the - claim 3 , wherein the linker is attached to said organocatalyst at C-11.6. The organocatalyst according to the previous claim 3 , wherein the support is selected from the group comprising silica gel claim 3 , mesoporous silica claim 3 , a soluble or insoluble polymer or a magnetic nanoparticle.7. The organocatalyst described in - for use in catalytic asymmetric hydrosilylations of ketimines and derivatives.8. The organocatalyst described in - for use in the transformation of ketimines and derivatives into chiral amines with enantioseletivities up to 90% ee. The present application refers to an organocatalytic ketimine hydrosilylation process to chiral amines.Organocatalysis is a subdivision of catalysis which relies on the use of wholly organic molecules as catalysts. These catalysts are very useful and have already made significant contributions in the production and discovery of new pharmaceuticals, agrochemicals and other high added value compounds (Alemán and Cabrera, 2013, MacMillan, 2008). The discovery of the Hajos-Parrish-Eder-Sauer-Wiechert reaction was the starting point (Eder et al. ...

PREPARATION OF FLUOROSULFONATE ESTERS AND ONIUM SALTS DERIVED THEREFROM

The present invention is directed to methods for preparing a fluorosulfonate ester or a salt thereof, through a reaction of a dissolved sulfonyl fluoride (RSOF) with alkoxide anion (RO) optionally in the presence of an aprotic base (B), where Ris fluorine or a C-Cperfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl. Alkoxide anion (RO) can be generated from a precursor such as an alcohol or silyl ester. 1. A method for preparing a fluorosulfonate ester or a salt thereof , comprising:{'sub': F', '2', 'F', '1', '8, 'sup': '−', 'reacting a dissolved sulfonyl fluoride (RSOF) with an alkoxide anion (RO) precursor in the presence of an aprotic base (B), wherein Ris fluorine or a C-Cperfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl group.'}2. The method of claim 1 , wherein Ris fluorine and the sulfonyl fluoride is SOF.3. The method of claim 1 , wherein the alkoxide anion (RO) precursor is a primary alcohol (ROH).4. The method of claim 1 , wherein the alkoxide anion (RO) precursor is a silyl ether having a formula ROSiR″ claim 1 , (RO)SiR″ claim 1 , (RO)SiR″ or (RO)Si claim 1 , and R″ is an alkyl group.5. The method of claim 1 , wherein the aprotic base (B) is a tertiary amine (R′N) claim 1 , wherein each R′ is independently a C-Calkyl or alkoxyalkyl claim 1 , a cycloalkyl claim 1 , morpholinyl claim 1 , or bicycloalkyl group.6. The method of claim 1 , wherein the aprotic base is a heteroaromatic tertiary amine.7. The method of claim 1 , wherein the reaction is conducted at or below atmospheric pressure.8. The method of claim 1 , further comprising: isolating a resulting fluorosulfonate ester RSOR.9. The method of claim 8 , wherein the alkoxide anion (RO) precursor is a hindered primary alkoxide.10. The method of claim 8 , wherein the aprotic base is a hindered base.11. The method of claim 1 , further comprising: isolating a resulting onium salt [RB][RSO].12. The method of claim 11 , wherein the resulting onium salt [RB][RSO] is obtained by reacting a ...

胺基富勒烯衍生物及其制备方法和应用

本发明公开了一种胺基富勒烯衍生物及其制备方法。该衍生物水溶性好，表面带正电荷，适合细胞吞噬，自由基捕获效率高，清除自由基的效果好；且在一定的浓度范围内不但没有细胞毒性，反而具有很好的细胞保护作用。所述制备方法产率高，提纯处理方法简便。

一种对苯二胺盐酸盐的合成方法

一种对苯二胺盐酸盐的合成方法，以N,N‑二甲基甲酰胺为溶剂，四甲基溴化铵为相转移催化剂，对苯二胺和氯化氢在一定条件下合成对苯二胺盐酸盐。在10℃~30℃下，向溶于对苯二胺的N,N‑二甲基甲酰胺溶液中通入氯化氢，其产品收率99.50%以上，产品纯度99.90%以上。

一种对苯二胺盐酸盐的合成方法

一种对苯二胺盐酸盐的合成方法，以N,N‑二甲基甲酰胺为溶剂，四甲基溴化铵为相转移催化剂，对苯二胺和氯化氢在一定条件下合成对苯二胺盐酸盐。在10℃~30℃下，向溶于对苯二胺的N,N‑二甲基甲酰胺溶液中通入氯化氢，其产品收率99.50%以上，产品纯度99.90%以上。

Способ получени хлоргидрата -метил-1адамантилметиламина

四（二甲氨基）锆的合成方法

本发明公开了一种四（二甲氨基）锆的合成方法，包括以下步骤：(1)保护气氛下，将四氯化锆与烷烃溶剂混合，得到混合液；(2)在‑20℃~‑10℃下，向混合液中通入二甲胺，反应后得到反应液；(3)在‑20℃~‑10℃下，向反应液中加入二烷基胺，发生反应；其中，二烷基胺为二乙胺、二正丙胺、二异丙胺、二正丁胺或二异丁胺；(4)减压蒸馏收集馏分，得到四（二甲氨基）锆。本发明提供的四（二甲氨基）锆的合成方法，无需使用在空气中自燃、操作危险系数极高的有机金属化合物，大大提高了生产的安全性；同时可有效降低原料成本，减少废液的产生，且缩短了四（二甲氨基）锆的生产周期并提高了收率，有利于大规模生产。

Preparation method of naftifine hydrochloride

本发明提供一种盐酸萘替芬的制备方法，以相对廉价的肉桂醇为原料，依次经氯代试剂氯代，甲胺化，1‑氯甲基萘取代，最后酸化成盐，结晶精制，得到成品。本发明的制备方法中前三步反应中的各中间体均无需纯化便进行反应，工艺过程持续无间歇，简化了操作，提高了产品的收率和生产效率，同时确保了产品的纯度，适合产业化，同时具有反应条件简单、成本低、环境友好的优点。

Low metal loaded, catalyst compositions including acidic mixed metal oxide as support

The invention provides a catalyst composition composed of a support portion and a catalyst portion. The support portion includes an acidic mixed metal oxide including a transitional alumina and a second metal oxide. The transitional alumina can comprise delta or theta alumina, in combination with other transitional phases, or an alpha or gamma alumina. The second metal oxide has a weight percentage that is less than the weight percentage of alumina. The catalyst portion is 25 weight percent or less of the catalyst composition and is composed of nickel and rhenium. The catalyst portion includes nickel in an amount in the range of 2 to 20 weight percent, based upon total catalyst composition weight, and there is no boron in the catalyst portion.

Selective preparation of diethylenetriamine

This invention relates to a method for controlling the weight ratio of diethylenetriamine to piperazine in a process in which ethylenediamine, or a mixture of ethylenediamine and monoethanolamine, and hydrogen are maintained in the presence of a hydrogenation catalyst, which method comprises adjusting the hydrogen concentration in the liquid phase in an amount sufficient to effectuate control of the weight ratio of diethylenetriamine to piperazine in said process.

Process for the preparation of diethylenetriamine and higher polyethylene polyamines by transamination of ethylenediamine

The invention relates to a process for the manufacture of diethylenetriamine and higher polyethylenepolyamines by a transamination of ethylenediamine. The transamination is performed at a temperature from 135° C. to 180° C. at a pressure from 5 Mpa to 40 Mpa in the presence of hydrogen and a particulate catalysts containing 26 to 65% by weight of nickel on an oxide carrier. A high conversion degree of ethylenediamine and a high selectivity to form acyclic polyethylenepolyamines, such as diethylenetriamine are obtained by the process. The formation of cyclic amine compounds, e.g. piperazine, is low.

Method for producing 1-adamantyl trimethylammonium hydroxide

본 발명은 1-아다만틸트리메틸암모늄 히드록시드를 제조하는 방법에 관한 것이다. The present invention relates to a process for preparing 1-adamantyltrimethylammonium hydroxide.

Process for producing 4-nitrodiphenylamine and 4-nitrosodiphenylamine from carbanilide

Dihydrobenzopyran derivs - as cardiac and respiratory analeptic agents and hypo tensive agents

Trimethylamine hydrochloride production process

本发明涉及化工产品生产领域，尤其是三甲胺盐酸盐生产领域。三甲胺盐酸盐是一种重要的化工产品。三甲胺盐酸盐生产装置为间歇式生产流程，主要包括合成、浓缩、提纯、干燥等。

Method for production of diethylene triamine and other linear polyethylene polyamines

FIELD: organic chemistry. SUBSTANCE: target products is produced by ethylene diamine transamination. Reaction is carried out at 135-180°C at pressure of 5-40 MPa in presence of hydrogen and catalyst particles containing 26-65 wt.% of metallic nickel on porous carrier. EFFECT: high ethylene diamine conversion ratio and high selectivity in relate to target acyclic polyethylene polyamines under advantageous reaction conditions. 10 cl, 2 tbl, 1 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (11) 2 281 936 (13) C2 (51) ÌÏÊ C07C 211/14 C07C 209/60 (2006.01) (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2004105150/04, 05.07.2002 (72) Àâòîð(û): ËÈÔ Éîõàí (SE), ÝÊÅÍÁÅÐà Êðèñòèíà (SE) (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 05.07.2002 (73) Ïàòåíòîîáëàäàòåëü(è): ÀÊÖÎ ÍÎÁÅËÜ Í (NL) R U (30) Êîíâåíöèîííûé ïðèîðèòåò: 24.07.2001 SE 0102590-7 (43) Äàòà ïóáëèêàöèè çà âêè: 10.08.2005 (45) Îïóáëèêîâàíî: 20.08.2006 Áþë. ¹ 23 2 2 8 1 9 3 6 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: GB 1508460 À, 26.04.1978. US 4956328 À, 11.09.1990. US 5410086 À, 25.04.1995. SU 106844 A, 24.09.1956. (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 24.02.2004 Àäðåñ äë ïåðåïèñêè: 103735, Ìîñêâà, óë. Èëüèíêà, 5/2, ÎÎÎ "Ñîþçïàòåíò", ïàò.ïîâ. À.Ï.Àãóðååâó (54) ÑÏÎÑÎÁ ÏÎËÓ×ÅÍÈß ÄÈÝÒÈËÅÍÒÐÈÀÌÈÍÀ È ÄÐÓÃÈÕ ËÈÍÅÉÍÛÕ ÏÎËÈÝÒÈËÅÍÏÎËÈÀÌÈÍΠ(57) Ðåôåðàò: Íàñòî ùåå èçîáðåòåíèå îòíîñèòñ ê ñïîñîáó ïîëó÷åíè äèýòèëåíòðèàìèíà è äðóãèõ ëèíåéíûõ ïîëèýòèëåíïîëèàìèíîâ ïóòåì òðàíñàìèíèðîâàíè ýòèëåíäèàìèíà. Ïðè ýòîì ðåàêöèþ ïðîâîä ò ïðè òåìïåðàòóðå 135-180°Ñ, ïîä äàâëåíèåì 5-40 ÌÏà, â ïðèñóòñòâèè âîäîðîäà è ÷àñòèö êàòàëèçàòîðà, ñîäåðæàùåãî îò 26 äî 65 âåñ.% ìåòàëëè÷åñêîãî íèêåë íà ïîðèñòîì îêñèäíîì íîñèòåëå. Ñïîñîá îäíîâðåìåííî îáåñïå÷èâàåò âûñîêóþ ñòåïåíü ïðåâðàùåíè ýòèëåíäèàìèíà è âûñîêóþ ñåëåêòèâíîñòü â îòíîøåíèè öåëåâûõ àöèêëè÷åñêèõ ïîëèýòèëåíïîëèàìèíîâ ïðè áëàãîïðè òíûõ óñëîâè õ ðåàêöèè. 9 ç.ï. ô-ëû, 2 òàáë. R U 2 2 ...

METHOD FOR PRODUCING 1-ADAMANTYLTRIMETHYLAMMONIDE HYDROXIDE

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2015 145 732 A (51) МПК C07C 209/68 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015145732, 27.03.2014 (71) Заявитель(и): ДЖОНСОН МЭТТИ ПАБЛИК ЛИМИТЕД КОМПАНИ (GB) Приоритет(ы): (30) Конвенционный приоритет: 27.03.2013 US 61/805,654 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 27.10.2015 R U (43) Дата публикации заявки: 05.05.2017 Бюл. № 13 (72) Автор(ы): БРАЙАН Ричард (GB), ДЖОУНЗ Рональд (GB), РОБИНСОН Найджел (GB) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2014/155118 (02.10.2014) A Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" R U (57) Формула изобретения 1. Способ получения 1-адамантилтриметилгидроксида аммония, который включает: (a) реакцию 1-адамантилдиметиламина с диметилкарбонатом для получения метилкарбоната 1-адамантилтриметиламмония; и (b) реакцию метилкарбоната 1-адамантилтриметиламмония с гидроксидом кальция или гидроксидом магния в присутствии воды для получения 1адамантилтриметилгидроксида аммония. 2. Способ по п. 1, где молярное отношение диметилкарбонат:1адамантилдиметиламин находится в диапазоне от 3 до 5. 3. Способ по п. 1 или 2, где молярное отношение гидроксид кальция или гидроксид магния:метилкарбонат 1-адамантилтриметиламмония находится в диапазоне от 1,05 до 1,75. 4. Способ по п. 1 или 2, где реакцию метилкарбоната 1-адамантилтриметиламмония с гидроксидом кальция или гидроксидом магния в присутствии воды осуществляют с обратным холодильником. 5. Способ по п. 1 или 2, где реакцию 1-адамантилдиметиламина с диметилкарбонатом осуществляют при температуре в диапазоне 120-160°C. 6. Способ по п. 1 или 2, где метилкарбонат 1-адамантилтриметиламмония вступает в реакцию с гидроксидом кальция. 7. Способ по п. 1, где 1-адамантилдиметиламин получают посредством реакции Стр.: 1 A 2 0 1 5 1 4 5 7 3 2 (54) СПОСОБ ПОЛУЧЕНИЯ ГИДРОКСИДА 1-АДАМАНТИЛТРИМЕТИЛАММОНИЯ 2 0 ...

The preparation method of the ferrisodium of ethylenediamine two

本发明公开了一种乙二胺二铁钠的制备方法，包括以下步骤：（1）向氢氧化钠中加入5~6倍重量的水，搅拌，使氢氧化钠溶解，得溶液Ⅰ；（2）向溶液Ⅰ中依次加入间甲酚、乙醛酸、乙二胺以及硝酸铁，在60~65℃的条件下反应2~3h，烘干得乙二胺二铁钠。

Process for preparation of 4-nitrodiphenylamine and 4-nitrosodiphenylamine from carbanilide

本发明涉及制备4－硝基二苯基胺和4－亚硝基二苯基胺的方法,这两种胺是用于制备防臭氧剂的中间体4－氨基二苯基胺,其中在合适碱存在下N－碳酰苯胺与硝基苯反应,同时在该混合物中添加苯胺,以再生一定量的起始物N－碳酰苯胺。根据本发明的方法,可以高选择性和产率地制备4－硝基二苯基胺和4－亚硝基二苯基胺,而且与常规方法相比显著降低了副产物的量,不产生对环境有害的腐蚀性物质。

Process for preparing tert-butylamine

本发明提供一种制备叔丁胺的方法，采用带多管束膜催化剂的反应器，中间沿轴向设置一块隔板，隔板两侧的反应器内分别固定若干根轴向设置的表面覆有膜催化剂的惰性载体管，反应器顶部分别在隔板相对的两侧设置两个开口，一侧为进料口I，另一侧为出料口，反应器底部设置开口，为进料口II；MTBE和HCN作为进料I自进料口I进入反应器，HCN作为进料II自进料口II进入反应器，从出料口出料；表面覆有膜催化剂的惰性载体管采用ZrO 2 膜为载体，以金属盐离子修饰，得到催化剂膜。本发明采用特制的反应器进行反应，能够强化传质和消除孔内扩散，同时通过反应器内隔板的设置使物料定向移动，有利于延长物料与膜催化剂的接触时间和空间，对膜催化剂充分利用，提高反应中催化剂的利用率。

A method of preparing cinacalcet hydrochloride

本发明提供一种制备盐酸西那卡塞的方法，所述方法包括：以式I所示3‑(3‑三氟甲基苯基)丙醇为起始原料，与甲磺酰氯发生酰化反应得到式II所示甲基磺酰‑3‑(3‑三氟甲基苯基)丙酯；在K 2 CO 3 、KI、离子液体1‑丁基‑3‑甲基咪唑三氟甲磺酸盐存在下，使得式II所示甲基磺酰‑3‑(3‑三氟甲基苯基)丙酯与式III所示(R)‑1‑(1‑萘基)乙胺发生取代反应，得到含式IV所示化合物的体系；使得式IV所示化合物与盐酸进行成盐反应，得到目标产物盐酸西那卡塞。本发明通过在步骤2)的取代反应中加入微量KI和离子液体1‑丁基‑3‑甲基咪唑三氟甲磺酸盐，加快了取代反应的速度，提高了产物的收率和纯度。

METHOD FOR PRODUCING DIETHYLENETRIAMINE AND HIGH POLYETHYLENE POLYAMINES

ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (51) ÌÏÊ 7 (11) 2004 105 150 (13) A C 07 C 209/00, 211/14 ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÇÀßÂÊÀ ÍÀ ÈÇÎÁÐÅÒÅÍÈÅ (21), (22) Çà âêà: 2004105150/04, 05.07.2002 (71) Çà âèòåëü(è): ÀÊÖÎ ÍÎÁÅËÜ Í (NL) (30) Ïðèîðèòåò: 24.07.2001 SE 0102590-7 (43) Äàòà ïóáëèêàöèè çà âêè: 10.08.2005 Áþë. ¹ 22 (86) Çà âêà PCT: SE 02/01351 (05.07.2002) (74) Ïàòåíòíûé ïîâåðåííûé: ÔÎÌÈ×ÅÂÀ ÒÀÌÀÐÀ ÑÅÌÅÍÎÂÍÀ Àäðåñ äë ïåðåïèñêè: 103735, Ìîñêâà, óë. Èëüèíêà, 5/2, ÎÎÎ "Ñîþçïàòåíò", ïàò.ïîâ. Ò.Ñ.Ôîìè÷åâîé R U Ôîðìóëà èçîáðåòåíè 1. Ñïîñîá ïîëó÷åíè äèýòèëåíòðèàìèíà è äðóãèõ âûñøèõ ëèíåéíûõ ïîëèýòèëåíïîëèàìèíîâ ïóòåì òðàíñàìèíèðîâàíè ýòèëåíäèàìèíà, îòëè÷àþùèéñ òåì, ÷òî ðåàêöèþ ïðîâîä ò ïðè òåìïåðàòóðå 135-180°Ñ, ïîä äàâëåíèåì 5-40 ÌÏà, â ïðèñóòñòâèè âîäîðîäà è ÷àñòèö êàòàëèçàòîðà, ñîäåðæàùåãî îò 26 äî 65 âåñ.% ìåòàëëè÷åñêîãî íèêåë íà ïîðèñòîì îêñèäíîì íîñèòåëå. 2. Ñïîñîá ïî ï.1, îòëè÷àþùèéñ òåì, ÷òî òåìïåðàòóðà ðåàêöèè ñîñòàâë åò 145-165°Ñ. 3. Ñïîñîá ïî ï.1 îòëè÷àþùèéñ òåì, ÷òî íîñèòåëü ñîäåðæèò îêñèä àëþìèíè , äèîêñèä êðåìíè èëè ñìåñü, ñîäåðæàùóþ îêñèä àëþìèíè è äèîêñèä êðåìíè , è êàòàëèçàòîð ñîäåðæèò îò 30 äî 65 âåñ.% ìåòàëëè÷åñêîãî íèêåë . 4. Ñïîñîá ïî ï.3, îòëè÷àþùèéñ òåì, ÷òî íîñèòåëü ïðåäñòàâë åò ñîáîé îêñèä àëþìèíè èëè ñìåñü îêñèäà àëþìèíè è äèîêñèäà êðåìíè , ñîäåðæàùóþ, ïî ìåíüøåé ìåðå, 25 âåñ.% îêñèäà àëþìèíè . 5. Ñïîñîá ïî ï.1, îòëè÷àþùèéñ òåì, ÷òî êàòàëèçàòîð èìååò òàêîé ðàçìåð ÷àñòèö, ÷òî, ïî ìåíüøåé ìåðå, 80 âåñ.% ÷àñòèö èìåþò ðàçìåð îò 0,1 äî 10 ìì. 6. Ñïîñîá ïî ëþáîìó èç ïóíêòîâ 1-5, îòëè÷àþùèéñ òåì, ÷òî êðîìå ìåòàëëè÷åñêîãî íèêåë êàòàëèçàòîð òàêæå ñîäåðæèò, â âèäå ìåòàëëîâ, êîáàëüò, æåëåçî, ìåäü, ïàëëàäèé, èëè èõ ñìåñè â ñóììàðíîì êîëè÷åñòâå îò 0,1 äî 12 âåñ.% â ðàñ÷åòå íà êîëè÷åñòâî ìåòàëëè÷åñêîãî íèêåë . 7. Ñïîñîá ïî ëþáîìó èç ïï.1-5, îòëè÷àþùèéñ òåì, ÷òî êàòàëèçàòîð òàêæå ñîäåðæèò ìåòàëë, âûáðàííûé èç ãðóïïû, ñîñòî ùåé èç êàëüöè , ìàãíè , ñòðîíöè , ëèòè , íàòðè , êàëè , áàðè , öåçè , âîëüôðàìà, æåëåçà, ...

Reclaiming toluenediamine from tar waste residue discharged from synthesis of toluene diisocynate

본 발명은 톨루엔 디이소시아네이트(TDI) 합성과정에서 배출되는 타르 폐기물로부터 톨루엔 디아민을 회수하는 방법에 관한 것이다. 상기 방법의 반응조건은 온화하고, 반응 온도는 120~180℃이며, 압력은0~0.95MPa이며, TDA회수율은 60%에 달하며, 상이동 촉매와 물을 순환 사용할 수 있다. The present invention relates to a method for recovering toluene diamine from tar waste discharged during the synthesis of toluene diisocyanate (TDI). The reaction conditions of the process are mild, the reaction temperature is 120 to 180 ° C, the pressure is 0 to 0.95 MPa, the TDA recovery rate is 60%, and the phase transfer catalyst and water can be circulated.

Method of producing crystal salt of s-6-fluorine-4-(benzyloxycarbrnylamino)-chroman-4-carboxylic acid and 1-(-)-alpha-methylbenzylamine

Chiral sorbinil intermediates of the formula wherein R is hydrogen or benzyloxycarbonyl and Y is hydroxy or amino, processes therefor, and processes forthe conversion thereof to sorbinil.

Polyoximino naringenin derivative as well as preparation method and application of polyoximino naringenin derivative

本发明公开了一种多肟基柚皮素衍生物及其制备方法和应用，其结构通式为： 其中，R 1 表示CH 3 、C 6 H 5 或p-ClC 6 H 4 中的任一种；R 2 表示OH或

Preparation method of 1-methylundecylamine

本发明属于化合物制备技术领域，特别涉及一种1‑甲基十一烷基胺的制备方法，包括以下步骤：（1）滴加保温反应；（2）水解、萃取及分离；（3）碱解精馏。本发明将反应生成的中间产物通过萃取分离法进行分离，回收第一步中加入的硫酸溶液，硫酸溶液的回收套用量可达原始用量的70%以上，碱解反应在碱性条件下进行，由于大部分硫酸已经被萃取分离出来，因此可以减少中和硫酸所需要的碱的量，减少用量约为原碱用量的50%，本发明可减少酸和碱的单耗，废水总量可降低75%以上，降低了单耗，节约了成本。

Process for preparing cis-aminochromanols

Patent FR2132627A1

Patent FR2491059B2

Preparation method of terbinafine hydrochloride

本发明提供了一种盐酸特比萘芬的制备方法，包括步骤：于缚酸剂A中，N‑甲基‑1‑萘甲胺(Ⅱ)与(E)‑1，3‑二氯丙烯(Ⅲ)经取代反应得N‑(3‑氯烯丙基‑1)‑甲基‑1‑萘甲胺(Ⅳ)反应液；将反应液中N‑(3‑氯烯丙基‑1)‑甲基‑1‑萘甲胺(Ⅳ)与3，3‑二甲基‑1‑丁炔(Ⅴ)在复合催化剂和缚酸剂B作用下缩合反应得到(E)‑N‑(6，6‑二甲基‑2‑庚烯‑4‑炔基)‑N‑甲基‑1‑萘甲胺(Ⅵ)的反应液；反应液经过氨水络合水洗处理，得油状物；之后在盐酸水溶液中成盐得到盐酸特比萘芬粗品，经重结晶得到盐酸特比萘芬。本发明的制备方法不使用有机溶剂，环境友好，成本低，操作简单，适宜工业化生产。

Meta-chloro-aniline(s) prepn. by catalytic dehydrochloridation - with hydrogen, noble metal catalyst and Lewis acid in anhydrous medium, yields plant protection agent intermediates

Process for the prepn. of meta-chloro-aniline derivs. (II), comprises liq.-phase catalytic hydrogenation, at elevated temp.and pressure, in the presence of Group VIII noble metals, of nitrogen and chloro-substd. benzene deriVs. of formula (I). The reaction is conducted in anhydrous medium in the presence of catalytic quantities of at least one Lewis acid catalyst. In (I) Y is H or O, X1, X2 are Cl, H, alkyl, aryl, aralkyl, alkoxy or aralkoxy (all opt. substd.), with the condition that at least one gp. is Cl; R1, R2, R3 are Cl, H, alkyl, aryl, aralkyl, alkoxy or aralkoxy (all gps. opt. substd.), with the condition that at least one is Cl. The poly-chloro-anilines are intermediates, esp. for plant protection agents. Known hydrogenation process for preparing (II) (FR2298531) uses high pressure and large amounts of hydrochloric acid which causes serious corrosion problems, the present invention avoids these corrosion problems.

Manufacture of nitroodiphenylamine derivative

Process and intermediates for sorbinil

Chiral sorbinil intermediates of the formula wherein R is hydrogen or benzyloxycarbonyl and Y is hydroxy or amino, processes therefor, and processes forthe conversion thereof to sorbinil.

Process for producing optically active amines

Disclosed is a process for producing an optically active amine represented by the formula (IV) (see formula IV) wherein R7 and R8 each denote an alkyl group, aryl group or aralkyl group, providing that they do not denote the same group at the same time, and * indicates an asymmetric carbon atom, which comprises reacting an asymmetric reducing agent obtained from (1) an optically active amine derivative represented by the formula (I) (see formula I) wherein R1 denotes an alkyl group, aryl group or aralkyl group; R2 denotes a hydrogen atom, alkyl group or aralkyl group; R3 denotes an aryl group or a substituent represented by the formula (II) (see formula II) wherein R4 and R5 each denote a hydrogen atom, aryl group or aralkyl group, and * is as defined above, (2) a metal borohydride and (3) sulfuric acid, with either the syn-isomer or the anti-isomer of an oxime derivative represented by the formula (III) or with a mixture rich in either one of the two isomers (see formula III) wherein R6 denotes an alkyl group, aralkyl group or alkyl-substituted silyl group, and R7 and R8 are as defined above. The optically active amine obtained can be used as a resolving agent for preparing medicinal agents, agricultural chemicals, or intermediates thereof .

Process for preparing tetraethylenepentamine

1,1-diphenyl-4-(substituted-amino) butanes

ABSTRACT OF THE DISCLOSURE The present invention relates to novel diphenyl-butyl-mono- or di-(C3-C4)alkylamines and to a process for the preparation thereof by reacting 1,1-diphenyl-4-substituted-butane with a mono-or di-(C3-C4)alkylamine or by hydrogenating 1,1-diphenyl- mono- or di-(C3-C4)alkylaminobutene, and if desired, forming the pharmaceutically acceptable salts thereof. The product compounds have anti-arrhythmia activity.

The Preparation Method And Their Intermediate of CP-45634

分子式为

METHOD FOR REMOVING NITROSAMINS

Processes for preparing 6,7,8-trihydroxy-1-(hydroxymethyl)-3-oxo-2-oxa-4-azabicyclo[3.3.1]nonane

本发明提供了6，7，8-三羟基-1-(羟甲基)-3-氧代-2-氧杂-4-氮杂双环[3.3.1]壬烷的制备方法以及制备井冈霉醇胺及其衍生物的方法。

A kind of perovskite structural material and preparation method thereof, application

本发明公开一种钙钛矿结构材料及其制备方法、应用，其中，所述含氟钙钛矿结构材料的化学式为RNH 3 MX 3‑a Y a ，其中，R为氟代烷基，M为金属元素，X和Y各自为Cl、Br或I中的任意一种，0≦a≦3；本发明提供的含氟钙钛矿结构材料，氟元素取代了烷基上的部分氢元素，使得制备的含氟钙钛矿结构材料具有较强的疏水性能，在空气中稳定性能较强，不易被氧化，能够广泛地应用于太阳能电池领域。

Manufacturing method for 4-nitrosoaniline from urea and nitrobenzene

Disclosed herein is a method for preparing 4-nitrosoaniline, comprising reacting urea and nitrobenzene in a polar organic solvent in the presence of a base at a temperature of room temperature to 150 °C. The method uses a relatively cheap urea and nitrobenzene as the raw materials, and also a relatively cheap base, thereby decreasing the manufacturing cost. Urea used as an amine donor is excellent in a reactivity to nitrobenzene, and a reaction intermediate is unstable as compared with 4-(4-nitrophenyl)benzamide to easily decompose into 4-nitroaniline and 4-nitrosoaniline. This allows a reaction time and a process time to be shortened. Moreover, the method is advantageous in that waste hazardous to the environment is not produced as a byproduct.

The preparation method of 1- adamantyl trimethylammonium hydroxide

公开了一种制备1‑金刚烷基三甲基氢氧化铵的方法。该方法包括使1‑金刚烷基二甲胺与碳酸二甲酯反应，以生成1‑金刚烷基三甲基甲基碳酸铵，其然后在水存在下与氢氧化钙或氢氧化镁反应，以生成1‑金刚烷基三甲基氢氧化铵。

Process for producing trifluoromethylbenzylamines

The present invention relates to a process for producing a trifluoromethylbenzylamine represented by the general formula (1), where R 1 represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group. This process includes the step of reducing an oxime by hydrogen in an organic solvent in the presence of a catalyst and ammonia. The oxime is represented by the general formula (2), where R 1 is defined as above, and R 2 represents hydrogen atom, an alkyl group or an aralkyl group. With this process, the trifluoromethylbenzylamine can be produced with high yield.

Preparation of fluorosulfonate onium salts

Method of preparing tetramethylammonium azide

Tetramethylammonium azide, N(CH 3 ) 4 N 3 , is prepared by a new process per the present invention. In the prior art, preparation of such azide was by use of shock-sensitive starting materials, i.e. AgN 3 and HN 3 . The method of the present invention provides a new method for making such azide at high purity, at room temperature, without the use of shock-sensitive materials.

Preparation of fluorosulfonic acid ester and onium salt derived thereform

Process for the production of diethylenetriamine and higher polyethylene polyamines

Preparation method of tetraphenyl borate

本发明公开了一种四苯基硼酸盐的制备方法，在水和有机溶剂协同作用下，使四苯基硼酸钠与季盐化合物反应，制得四苯基硼酸盐产品，所述有机溶剂是指能溶解季盐化合物且不参与反应的有机溶液，该方法实现了在水和有机溶液组成的混合反应体系中，使得四苯基硼酸钠与季盐化合物几乎定量地反应并得到有机的四苯基硼酸季盐产品的过程，产品纯度高，副产物钠盐全部溶于水，因此，无干扰副产物，适用于有机四苯硼酸盐的高效、高纯度的规模化制备生产。

Synthesis method of D- (-) -pantoic acid lactone

本发明公开了一种维生素B5合成关键中间体D‑(‑)‑泛解酸内酯的合成方法，采用(R)‑(+)‑α‑苯乙胺盐酸盐或者硫酸盐作为手性拆分试剂与外消旋的泛解酸碱金属盐反应，过滤除去无机盐，母液浓缩得泛解酸‑(R)‑苯乙胺非对映体复盐，采用重结晶或打浆的方法对非对映体复盐进行纯化，过滤得(D)‑泛解酸‑(R)‑苯乙胺复盐，而(L)‑泛解酸‑(R)‑苯乙胺复盐溶解在溶剂中，(D)‑泛解酸‑(R)‑苯乙胺复盐再经过分解、酸化环合得到D‑(‑)‑泛解酸内酯。

Blowing agents comprising polyamines and alkanolamine salts and use in polyurethane continuous panel foam materials

包含多胺和醇胺盐的发泡剂及用于聚氨酯连续板泡沫体材料中的用途。公开了包含多胺盐和醇胺盐的一种聚氨酯发泡剂，该发泡剂包括：1)包含具有以下通式(I)的有机多胺盐化合物类的第一种化合物混合物(M1)：A ‑ B + (I)，其中，B + 是有机多胺B的阳离子，A ‑ 是：CO 3 2‑ ，HCO 3 ‑ ，或CO 3 2‑ 与HCO 3 ‑ 的结合物；2)包含具有通式(II)的N‑单羟丙基/单羟乙基‑碳酸铵化合物和具有通式(II)的N,N'‑二(羟丙基/羟乙基)‑碳酸铵化合物的第二种化合物混合物(M2)：(RN + H 3 )(N + H 4 )CO 3 2‑ (II)，或(RN + H 3 ) 2 CO 3 2‑ (III)，式中，R为羟丙基与羟乙基的结合物；通式(II)的单醇胺化合物与通式(III)的二醇胺化合物的摩尔比是1:0至1:2.5。发泡剂适合用于制备聚氨酯连续板泡沫体材料。

Manufacturing method for 4-nitrosoaniline from urea and nitrobenzene

A method for preparing 4-nitrosoaniline, including reacting urea and nitrobenzene in a polar organic solvent in the presence of a base at a temperature of room temperature to 150° C. The method uses a relatively cheap urea and nitrobenzene as the raw materials, and also a relatively cheap base, thereby decreasing the manufacturing cost. Urea used as an amine donor is excellent in a reactivity to nitrobenzene, and a reaction intermediate is unstable as compared with 4-(4-nitrophenyl)benzamide to easily decompose into 4-nitroaniline and 4-nitrosoaniline. This allows a reaction time and a process time to be shortened. Moreover, the method is advantageous in that waste hazardous to the environment is not produced as a byproduct.

Production of nitrodiarylamines

Preparation of primary and secondary amines from alkyl sulfates

Process for the production of hexamethylenediamine

Method of preparing substituted aromatic amines

FIELD: chemical industry. SUBSTANCE: substituted aromatic azocompound or azoxy or hydazo derivative thereof is contacted with alcohol selected from group consisting of aliphatic alcohols, cycloatiphatic alcohols, arylalkyl alcohols and mixtures thereof in the presence of suitable base at temperatures from 70 C to 200 C where substituted aromatic azocompound is selected from group consisting of compound represented by formulas: (R-NH)-R 1 (X)-N=N-R 2 (Y) (I), (R-NH)-R 1 (X)-N=N-R 2 (Y)-(NH-R), X-R 1 -N=N-R 2 (Y)-(NH-R) (III) or mixtures thereof wherein R-NH,R 1` ,R 2 X and Y are as defined in claim 1. EFFECT: simplified process and greater economic efficiency thereof. 13 cl, 11 ex, 2 tbl УЕбУУГЕС ПЧ Го (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВИ” 2144 914 ' (51) МПК? 13) СЛ С 07 С 211/45, 211/55, 245/08, 209/30, 209/42 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 96112149/04, 12.10.1994 (24) Дата начала действия патента: 12.10.1994 (30) Приоритет: 05.11.1993 1$ 147619 (46) Дата публикации: 21.01.2000 (56) Ссылки: МО 9300324, 07.01.93. 4$ 4941997, 1990. 5Ц 517582 АЛ, 1978. СКС НапаЯ9ок от Спет! гу апа Рпуз!с$з. 58, 1977-1978, р.131-138. (85) Дата перевода заявки РСТ на национальную фазу: 05.06.1996 (86) Заявка РСТ: 1$ 94/11532 (12.10.1994) (87) Публикация РСТ: М/О 95/12569 (11.05.1995) (98) Адрес для переписки: 129010, Москва, ул.Большая Спасская, 25, стр.3, "Городисский и Партнеры" (71) Заявитель: Монсанто Компани (1$) (72) Изобретатель: Брайан Кай-Минг Ченг (ЦЗ), Майкл Кит Стерн (ЦЗ) (73) Патентообладатель: Монсанто Компани (1$) (54) СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ АРОМАТИЧЕСКИХ АМИНОВ (57) Реферат: Описывается способе получения замещенного ароматического амина, отличающийся тем, что замещенное ароматическое азосоединение или его азокси- или гидразопроизводное контактирует со спиртом, выбранным из группы, содержащей алифатические спирты, циклоалифатические спирты, арилалкиловые спирты и их смеси, в присутствии подходящего ...

Direct process for the manufacture of tetraalkylammonium tetrafluoroborate-containing electrolyte compositions

본 발명에 따라서 (ⅰ)최소 하나의 테트라알킬암모늄 할라이드와 최소 하나의 금속 테트라플루오로보레이트를 물과 부분적으로 또는 완전히 혼화성인, 최소 하나의 유기 용매에서 혼합하는 단계 를 포함하는 테트라알킬암모늄 테트라플루오로보레이트-함유 전기분해 조성물의 제조방법이 제공된다.

The preparation method of N, N- dimethyl cyclohexyl amine

本发明公开了一种N，N‑二甲基环己胺的制备方法，包括以下步骤：1）将催化剂、环己酮加入反应器中，氮气氢气置换各三次；2）控制温度，保持物料在反应器内循环喷射；泵入液体二甲胺；3）通入氢气，保证系统压力在0.5‑2.0MPa；4）吃氢不明显时，取样检测，直至原料环己铜含量<0.1%时，泄压过滤后出料，再经脱氨，减压蒸馏得成品。喷射反应器使反应物充分混合，有利于强化传质与传热，加快反应速率，改善浓度和温度分布，抑制副反应，提高反应的选择性。

Magnesium/aluminum mixed oxide catalysts

ABSTRACT Calcined magnesium/aluminum mixed oxide catalysts derived from water-insoluble magnesium and aluminum carbonate containing salts, which catalysts are particularly useful in the production of aminoethers, especially bis(2-dimethylaminoethyl) ether.

A process for the manufacture of diethylenetriamine and higher polyethylenepolyamines

The invention relates to a process for the manufacture of diethylenetriamine and higher polyethylenepolyamines by a transamination of ethylenediamine. The transamination is performed at a temperature from 135°C to 180°C at a pressure from 5 Mpa to 40 Mpa in the presence of hydrogen and a particulate catalysts containing 26 to 65% by weight of nickel on an oxide carrier. A high conversion degree of ethylenediamine and a high selectivity to form acyclic polyethylenepolyamines, such as diethylenetriamine are obtained by the process. The formation of cyclic amine compounds, e.g. piperazine, is low.

Process for producing optically active amines

Disclosed is a process for producing an optically active amine represented by the formula (IV) (see formula IV) wherein R7 and R8 each denote an alkyl group, aryl group or aralkyl group, providing that they do not denote the same group at the same time, and * indicates an asymmetric carbon atom, which comprises reacting an asymmetric reducing agent obtained from (1) an optically active amine derivative represented by the formula (I) (see formula I) wherein R1 denotes an alkyl group, aryl group or aralkyl group; R2 denotes a hydrogen atom, alkyl group or aralkyl group; R3 denotes an aryl group or a substituent represented by the formula (II) (see formula II) wherein R4 and R5 each denote a hydrogen atom, aryl group or aralkyl group, and * is as defined above, (2) a metal borohydride and (3) sulfuric acid, with either the syn-isomer or the anti-isomer of an oxime derivative represented by the formula (III) or with a mixture rich in either one of the two isomers (see formula III) wherein R6 denotes an alkyl group, aralkyl group or alkyl-substituted silyl group, and R7 and R8 are as defined above. The optically active amine obtained can be used as a resolving agent for preparing medicinal agents, agricultural chemicals, or intermediates thereof .

1,1-DIPHENYL-4- (AMINO SUBSTITUTE) BUTANES

Process control method for synthesizing 3-cyano-2, 6-dihydroxy-4-trifluoromethylpyridine triethylamine salt

本发明属于磁共振分析领域，具体涉及一种定量核磁共振氟谱测定三氟乙酰乙酸乙酯和氰基乙酰胺反应生成3‑氰基‑2,6‑二羟基‑4‑三氟甲基吡啶三乙胺盐过程控制中原料转化率和产物含量的方法。该方法分别采集关键原料和产物的核磁共振氟谱，通过推定各个组分的氟化学位移，进而积分得到各部分氟的峰面积，再计算得出3‑氰基‑2,6‑二羟基‑4‑三氟甲基吡啶三乙胺盐的含量以及三氟乙酰乙酸乙酯的含量和转化率。本发明的方法操作简便、可快速准确地实现合成3‑氰基‑2,6‑二羟基‑4‑三氟甲基吡啶的过程控制，为目标产品的制备提供有力的支持。

Process for preparing sorbinil intermediates and process for the conversion thereof to sorbinil

The title compds. II [R-H, benzyloxycarbonyl; Y=OH, amino! were prepd. Thus, 6.9g S-b-fluoro-4-(benzyloxycarbonylamino) chroman-4- carboxylic acid in 100ml methanol was mixed with 0.5g 5%-Pd/c and then the resulting mixt. was treated with hydrogen at 4 atm for 2-3h. The catalyst was removed. The resulting soln. was concd. and treated with toluene to give 3.9g S-b-fluoro-4-aminochroman-4-carboxylic acid.

FRAMSTAELLNINGSFOERFARANDEN FOER SORBINIL SAMT MELLANPRODUKTER.

Chiral sorbinil intermediates of the formulawherein R is hydrogen or benzyloxycarbonyl and Y is hydroxy or amino, processes therefor, and processes forthe conversion thereof to sorbinil.

METHOD FOR CLEANING UP DINITROANILINES

Tricyclic amines - anti-depressants sedatives

The purification process and 1,5 pentanediamines of a kind of 1,5 pentanediamine

The invention provides the purification process of one kind 1,5- pentanediamines, including：1,5- pentanediamines to be purified are provided；And handle 1, the 5- pentanediamines to be purified, 1, the 5- pentanediamines purified using reduction reaction.Present invention also offers one kind 1,5- pentanediamines as made from the above method.The purification process for 1, the 5- pentanediamines that the present invention is provided, concise in technology is simple to operate, it is adaptable to industrialized production, can significantly improve the quality of 1,5- pentanediamines.

A kind of method 1,5- pentanediamine extraction and coupled at salt

本发明公开了一种1,5‑戊二胺萃取和成盐耦合的方法，包括以下步骤：(1)调节1,5‑戊二胺溶液的pH至13，将碱性1,5‑戊二胺溶液和有机溶剂混匀，静置10min萃取1,5‑戊二胺；(2)将步骤(1)得到的轻相置于反应容器中，通入酸性气体进行成盐反应；(3)将步骤(2)得到的反应液静置析出固体，固液分离、干燥得到晶体。本发明首次提出了萃取成盐耦合的方法制备PDI的前体化合物，大大简化了操作条件，省时省力；且可以减少杂质提高产品纯度、提高收率，更利于光气化反应生产PDI。

A kind of synthetic method of amantadine hydrochloride

本发明公开了一种盐酸金刚烷胺的合成方法，包括1‑乙酰胺基金刚烷制备、金刚烷胺制备、盐酸金刚烷胺制备，其中，1‑乙酰胺基金刚烷制备步骤为：将乙腈滴加至20％的发烟硫酸中，加入镍铑双金属催化剂和金刚烷，升温，反应完成后，缓慢滴加冰盐水稀释、萃取、洗涤、干燥、蒸除溶剂，得1‑乙酰胺基金刚烷。有益效果为：本发明使用氧化铝负载的镍铑双金属催化剂催化金刚烷的乙酰氨化反应，镍、铑之间协同作用，增强催化活性，促进反应进行，同时抑制副反应的发生，提高目标产物的收率；本发明避免使用溴素原料，避免了溴素对设备的腐蚀和对环境的污染，环保性好，合成方法条件温和，工艺简单可行，产品收率高。

DIHYDROBENZOPYRAN DERIVATIVES AND METHOD FOR MANUFACTURING THE SAME

Improved process for the preparation of 2- (4-trifluoromethoxyphenyl) ethylamine and 4-bromomethyl and 4-chloromethyl-1-trifluoromethoxy-benzene

Man kann 2-(4-Trifluormethoxyphenyl)-ethylamin in vorteilhafter Weise herstellen, wenn man Trifluormethoxybenzol durch Halogenmethylierung in Halogenmethyl-1-trifluormethoxy-benzol umwandelt, diese Verbindung durch einen Halogen-Cyan-Austausch in 4-(Trifluormethoxyphenyl)-acetonitril überführt und diese schließlich mit Wasserstoff in Gegenwart eines Nickelkatalysators reduziert. Die erste Stufe dieses Verfahrens stellt auch ein vorteilhaftes Verfahren zur Herstellung von 4-Brommethyl- und 4-Chlormethyl-1-trifluormethoxy-benzol dar. 2- (4-Trifluoromethoxyphenyl) ethylamine can be produced in an advantageous manner if trifluoromethoxybenzene is converted into halomethyl-1-trifluoromethoxybenzene by halogenomethylation, this compound is converted into 4- (trifluoromethoxyphenyl) acetonitrile by a halogen-cyano exchange finally reduced with hydrogen in the presence of a nickel catalyst. The first stage of this process also represents an advantageous process for the preparation of 4-bromomethyl and 4-chloromethyl-1-trifluoromethoxy-benzene.

Process for preparing cis- aminochromanols

cis-aminochromanols are obtained in high yield and with high selectivity over their trans counterparts by hydrogenating the corresponding oximes in the presence of a catalyst and an acid selected from HBr, HCl, and organic sulfonic acid. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.

Extractive method for the preparation of quaternary salts

Quaternary (e.g., tetraalkylammonium and tetraalkylphosphonium) salts containing non-halide anions are prepared by performing an anion exchange reaction by liquid-liquid extraction with a chlorinated solvent of a mixture of an aqueous solution an alkali metal salt of the anion and a corresponding quaternary halide.

Process for the preparation of primary amines

Amines of formula (I) are prepared (a) by reacting a precursor for a carbenium ion of the formula R1R2R3C<+> with a nitrile in the presence of a strong acid; and (b) releasing (I) from its salt with the acid using ammonia or an amine. R2, R3 = alkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, hydroxyalkyl, hydroxycycloalkyl, arylalkyl or aryl; R1 = H or as for R2, R3; or R1 = H and CR2R3 = cycloalkyl.

Synthesis method of tetra (dimethylamino) zirconium

本发明公开了一种四（二甲氨基）锆的合成方法，包括以下步骤：(1)保护气氛下，将四氯化锆与烷烃溶剂混合，得到混合液；(2)在‑20℃~‑10℃下，向混合液中通入二甲胺，反应后得到反应液；(3)在‑20℃~‑10℃下，向反应液中加入二烷基胺，发生反应；其中，二烷基胺为二乙胺、二正丙胺、二异丙胺、二正丁胺或二异丁胺；(4)减压蒸馏收集馏分，得到四（二甲氨基）锆。本发明提供的四（二甲氨基）锆的合成方法，无需使用在空气中自燃、操作危险系数极高的有机金属化合物，大大提高了生产的安全性；同时可有效降低原料成本，减少废液的产生，且缩短了四（二甲氨基）锆的生产周期并提高了收率，有利于大规模生产。

Low metal (nickel and rhenium) catalyst compositions including acidic mixed metal oxide as support

The invention provides a catalyst composition composed of a support portion and a catalyst portion. The support portion includes an acidic mixed metal oxide including a transitional alumina and a second metal oxide. The transitional alumina can comprise delta or theta alumina, in combination with other transitional phases, or an alpha or gamma alumina. The second metal oxide has a weight percentage that is less than the weight percentage of alumina. The catalyst portion is 25 weight percent or less of the catalyst composition and is composed of nickel and rhenium. The catalyst portion includes nickel in an amount in the range of 2 to 20 weight percent, based upon total catalyst composition weight, and there is no boron in the catalyst portion.

Method of making a templating agent

Preparation of fluorosulfonate esters and onium salts derived therefrom

The present invention is directed to methods for preparing a fluorosulfonate ester or a salt thereof, through a reaction of a dissolved sulfonyl fluoride (R F SO 2 F) with alkoxide anion (RO − ) optionally in the presence of an aprotic base (B), where R F is fluorine or a C 1 -C 8 perfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl. Alkoxide anion (RO − ) can be generated from a precursor such as an alcohol or silyl ester.

Synthesis method of bributin hydrochloride

本发明属于药物合成技术领域，具体涉及一种盐酸布替萘酚的合成方法；以N‑甲基‑4‑叔丁基苄胺、1‑萘甲醛为原料，在酸试剂作用下，加入催化剂，反应体系通入H 2 ，控温至反应结束后，反应液降至室温后调至中性，过滤，滤液经萃取剂萃取，萃取液减压浓缩后，经HCl/有机溶剂成盐，过滤，滤饼减压干燥后即为盐酸布替萘酚；本发明的反应条件温和，操作过程简便，生产成本低，产品具有较高的纯度、收率。

A kind of synthetic method of Butenafine

本发明提供了一种布替萘芬的合成方法，步骤是：向溶剂中加入一甲胺，然后加入缚酸剂；同时缓慢滴加1‑氯甲基萘和对叔丁基氯苄，控制滴加速度，使1‑氯甲基萘和对叔丁基氯苄同时滴加完毕，然后控温10‑20℃保温反应4小时；用氯仿萃取反应液，减压浓缩有机层至干，向残留物中加入异丙醇析晶得布替萘芬。本发明方法操作方便，副产物少，收率高，生产周期短，利于工业化生产。

Preparation method of sorbose couplyl and intermediate thereof

分子式为 的手性山梨糖偶酰中间体，其中Ｒ为氢或苄氧基羰基，Ｙ为羟基或氨基，其制备及转化为山梨糖偶酰的方法。

Preparation method of chiral alpha-methyl aromatic ethylamine

本发明提供了一种手性α‑甲基芳乙胺的制备方法，涉及有机合成药物技术领域。本发明使用Boc‑氨基酸甲酯作为起始原料，经还原得到Boc‑氨基醇，与氯化亚砜反应后，经高碘酸钠氧化得到磺酰胺化合物，再经路易斯酸促进的硼氢化钠还原，酸性条件脱除保护基得到目标化合物。本方法原料廉价易得，使用手性原料得到单一的光学异构体产物，克服了柱色谱拆分问题，避免大量固废和异构体的产生，提高了原子经济性，产物纯度高，收率高，有效的降低了生产成本。而且本发明使用温和的还原体系来替代原来的高压氢化反应，工艺操作相对简单，更适合规模化工业生产。

Method for preparing aromatic secondary amino compound

本发明公开了(1)芳香仲氨基化合物的制备方法，该方法包括在氢移动催化剂和氢受体存在下，通过使用无硫极性溶剂和/或助催化剂使N-亚环已基氨基化合物进行反应，以及 (2)芳香仲氨基化合物的制备方法，该方法包括在无硫极性溶剂中，于氢移动催化剂存在下，加或不加助催化剂使环已酮或环上取代环已酮、胺及相应于该胺的硝基化合物反应。

Oxacillin acid amine salt and related crystal form

本发明提供了一种稳定性良好的苯唑西林酸胺盐，基于该胺盐，本发明还提供了相关晶型及其制备方法，同时还提供了通过该苯唑西林酸胺盐制备苯唑西林钠的方法。

ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE BENZOPYRANE COMPOUNDS

Process for preparing substituted aromatic amines

A process for preparing substituted aromatic amines is provided which comprises contacting a substituted aromatic azo compound and an alcohol selected from the group consisting of aliphatic alcohols, cycloaliphatic alcohols, arylalkyl alcohols and mixtures thereof in the presence of a suitable base at a temperature of about 70 °C to about 200 °C. In another embodiment, the substituted aromatic amines of the invention are reductively alkylated to produce alkylated diamines or substituted derivatives thereof.

Method for preparing 1-adamantyltrimethylammonium hydroxide

公开了一种制备1-金刚烷基三甲基氢氧化铵的方法。该方法包括使1-金刚烷基二甲胺与碳酸二甲酯反应，以生成1-金刚烷基三甲基甲基碳酸铵，其然后在水存在下与氢氧化钙或氢氧化镁反应，以生成1-金刚烷基三甲基氢氧化铵。

Manufacturing method for 4-nitrosoaniline from urea and nitrobenzene

Amines

The method of obtaining derivatives bornilamina

The synthetic method of one kind (1- cyclopropyl -1- methyl) ethylamine and its hydrochloride

本发明公开了一种(1‑环丙基‑1‑甲基)乙基胺及其盐酸盐的合成方法。该方法为：步骤1，环丙甲基酮为原料，与甲基溴化镁反应可得到(1‑环丙基‑1‑甲基)乙醇，然后和氯磺酰异氰酸酯反应得到(N‑氯磺酰基‑1‑环丙基‑1‑甲基)乙基胺，得到的粗产品直接与氢氧化钠反应得到(1‑环丙基‑1‑甲基)乙基胺，进一步与盐酸反应即得到(1‑环丙基‑1‑甲基)乙基胺盐酸盐。本发明以较为简单的工艺，比现有技术更低的成本，较高的收率和高纯度制得(1‑环丙基‑1‑甲基)乙基胺，反应过程稳定，收率较高，并且成功的进行了放大生产。

Process for preparing ortho substituted phenylamines

A process is disclosed for preparing ortho substituted phenylamines comprising contacting phenylhydroxylamine, optionally substituted with at least one inert substituent, with a nucleophilic reagent in the presence of a manganese oxide at a temperature between about 10° C. and about 170° C. and a pressure from subatmospheric to superatmospheric such that an ortho substituted phenylamine, optionally correspondingly substituted with at least one inert substituent, is predominantly formed.

Zeolite H-ZK-5 as catalyst for conversion of methanol and ammonia to dimethylamine

A process is provided for producing dimethylamine comprising reacting methanol and/or dimethylether and ammonia in amounts sufficient to provide a carbon/nitrogen (C/N) ratio from about 0.2 to about 1.5, at a temperature from about 250° C. to about 450° C., in the presence of a catalytic amount of an acidic H-ZK-5 zeolite catalyst.

A kind of preparation method of naftifine hydrochloride

本发明提供一种盐酸萘替芬的制备方法，以相对廉价的肉桂醇为原料，依次经氯代试剂氯代，甲胺化，1‑氯甲基萘取代，最后酸化成盐，结晶精制，得到成品。本发明的制备方法中前三步反应中的各中间体均无需纯化便进行反应，工艺过程持续无间歇，简化了操作，提高了产品的收率和生产效率，同时确保了产品的纯度，适合产业化，同时具有反应条件简单、成本低、环境友好的优点。

The purification process and 1,5 pentanediamines of a kind of 1,5 pentanediamine

本发明提供了一种1,5‑戊二胺的纯化方法，包括：提供待纯化的1,5‑戊二胺；及利用还原反应处理所述待纯化的1,5‑戊二胺，得到纯化的1,5‑戊二胺。本发明还提供了一种由上述方法制得的1,5‑戊二胺。本发明提供的1,5‑戊二胺的纯化方法，工艺简洁，操作简单，适用于工业化生产，能显著提高1,5‑戊二胺的品质。

Manufacture of 4-aminochromanes

The invention comprises 4-aminochromanes of the formula: <FORM:0758313/IV(a)/1> (in which R1, R2, R4 and R5 each represent hydrogen or an alkyl group and may be the same or different, also R1 and R2 may together with the N atom form the residue of a heterocyclic ring, and R3 is an alkyl or a phenyl group) together with their salts, and a process for their preparation by converting the keto group of the corresponding 4-chromanone, if necessary or desired after intermediate conversion via the 4-chromanol into the group > CH Halogen, by treatment with an aminating agent into a 4-amino group, and if required converting said amino group with an N-alkylating agent into a substituted or further substituted 4-amino group. The intermediate 4-chromanol may also be prepared by reduction of the corresponding chromone. Direct amination of the chromanone is preferably effected by catalytic hydrogenation in the presence of ammonia or a primary or secondary amine, or by treatment with hydroxylamine and hydrogenation of the oxime produced, whilst amination of the 4-halo intermediate is effected with ammonia, or a primary or secondary amine. In examples: (1) 8-phenyl-4-chromanone (prepared from o-hydroxydiphenyl and b -halogenpropionyl chloride) is hydrogenated in methanol over Raney nickel, and the resulting chromanol treated with thionyl chloride in chloroform yielding 8-phenyl-4-chlorochromane, which is then treated overnight with dimethylamine and 4-dimethylamino-8-phenylchromane isolated as its hydrochloride; 4-diethylamino 8-phenylchromane is similarly prepared; (2) 8-phenyl-4-chromanone is converted to its oxime and then hydrogenated over palladium charcoal yielding 8 - phenyl - 4 - aminochromane hydrochloride, which is alkylated with formaldehyde-formic acid to 8 - phenyl - 4 - dimethylaminochromane hydrochloride; (3) 8-phenyl-4-chlorochromane with ethylamine gives 4-ethylamino-8-phenylchromane characterized as its tartrate and hydrochloride; (4) 8-phenyl-4- ...