Способ получения производных -фенилжирной кислоты

VERFAHREN ZUR HERSTELLUNG VON PHENYLESSIGSAEURE-DERIVATEN

SUBSTITUIERTE OXOCARBONSAEUREN, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG UND SIE ENTHALTENDE ARZNEIMITTEL

SUBSTITUTED 4-BIPHENYLYL-BUTENOIC ACIDS ESTERS AND AMIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

... 1410852 4-Biphenylyl-butenoic acids and their derivatives DR KARL THOMAE GmbH 16 Aug 1973 [17 Aug 1972] 38844/73 Heading C2C The invention comprises compounds of the formula wherein A is one of the groups R 1 is a halogen atom, B is OH, alkoxy or a group in which R 3 and R 4 are H, -CH 2 COOH, C 1 -C 3 alkyl or phenyl optionally substituted by OH or CH 3 , and where B is OH, the salts thereof with inorganic or organic bases. They may be obtained by (a) dehydrating a compound of the formula with a dehydrating agent; (b) when B is OH, saponifying a compound of Formula I in which B is alkoxy; (c) when B is alkoxy, esterifying a compound of Formula I in which B is OH; and (d) when B is reacting compounds in which B is alkoxy or compounds in which said alkoxy group is replaced by a halogen atom, with an amine of the formula Examples are given for the production of the compounds. The compounds of Formula I have antiphlogistic activity and may be administered orally, rectally or parenterally in ...

SUBSTITUTED-4-BIPHENYL-3-HYDROXYBUTYRIC ACIDS ESTERS AND AMIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

... 1411495 3 - (Fluoro - 4 - biphenylyl) - 3- hydroxy - butyric acids and derivatives thereof DR KARL THOMAE GmbH 16 Aug 1973 [17 Aug 1972] 38843/73 Heading C2C The invention comprises compounds of the formula wherein R 1 is F in the 21- or 41-position, B is OH, alkoxy or a group in which R 2 and R 3 are H, -CH 2 COOH, (C 1 -C 5 )alkyl or phenyl optionally substituted by OH or CH 3 , and where B is OH, the salts of thereof with inorganic or organic bases. Compounds in which B is alkoxy may be obtained by reacting a compound of the formula with the Zn compound of an appropriate haloacetate ester in the presence of an organic solvent. Compounds in which B is OH and salts thereof may be obtained by saponification of compounds of Formula I in which B is alkoxy with an alkali or a strong acid and liberating the free acids from salts thereof by acidification with a mineral acid. Compounds in which B is may be obtained by reacting compounds of Formula I in which B is alkoxy or compounds ...

4-substituted-2-indanols

Alcohols of the formula in which R<1> is phenyl, optionally substituted with halogen or C1-4 alkyl are novel. They can be used in preparing insecticides of the pyrethroid type.

A POLYPRENYL COMPOUND AND A PHARMACEUTICAL COMPOSITION CONTAINING A POLYPRENYL COMPOUND

POLYPRENYL COMPOUND

METHOD OF COATING

HETEROCYCLIC HYDROXY KETONES AND THEIR USE AS HERBICIDES

Manufacture of salts of terephthalic acid

Alkali metal salts of terephthalic acid are prepared by heating an alkali metal salt of pyromellitic acid to an elevated temperature in an inert atmosphere and in the presence of an alkali metal salt of benzoic acid. Specified alkali metal salts are those of sodium, lithium, rubidium or, preferably potassium. The alkali metal salts may be preformed or may be formed in situ, for example from pyromellitic anhydride, benzoic anhydride and an alkali metal carbonate. A metal catalyst may be used, the preferred one being cadmium benzoate. Specified reaction temperatures are above 300 DEG C., and preferably about 425 DEG C. Specified inert gases are carbon dioxide and nitrogen. Terephthalic acid may be obtained from the salts by known methods. In examples, pyromellitic anhydride, benzoic anhydride, potassium, sodium or lithium carbonate and cadmium benzoate were heated in a sealed vessel in an atmosphere of carbon dioxide, the reaction mixture extracted with water, filtered and the filtrate acidified ...

PROCESS FOR THE PREPARATION OF 2,2-DIMETHYL-3-(2'2'-DIHAL-OGENOVINYL)-CYCLO-PROPANE-1-CARBOXYLIC ACID ESTERS

New phenylacetic acid derivatives

Phenylacetic acid derivatives of the formula wherein n is an integer of 2 to 5; R1 is hydrogen, halogen, trifluoromethyl, nitro or amino; R2 and R3 each independently is hydrogen or lower alkyl; or together form an ethylene group; X1 represents two hydrogen atoms or an oxo group; and Y1 is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl or carboxyl; and for derivatives wherein Y is carboxyl, salts thereof with physiologically compatible bases, esters thereof from physiologically acceptable alcohols and amides thereof from physiologically acceptable amines have valuable pharmacological activity, e.g., as antiinflammatory agents.

NEW beta-PHENYL-FATTY ACID COMPOUNDS

... 1,260,875. Beta-phenyl-fatty acid derivatives. CIBA-GEIGY A.G. 24 Oct., 1969 [25 Oct., 1968; 23 May, 1969; 23 Sept., 1969], No. 52230/69. Heading C2C. Novel compounds I in which X is free, esterified or amidated carboxyl; A is a free or substituted OH group or together with B forms a bond; B is H, aliphatic hydrocarbyl, with A forms a bond or with R 2 forms a divalent aliphatic hydrocarbon residue; R 1 is H or aliphatic hydrocarbyl; R 2 is as R 1 or with B forms a divalent aliphatic hydrocarbon residue; Ph is phenylene optionally substituted by alkyl, halo, CF 3 , amino or nitro and R is cycloaliphatic hydrocarbyl which may be substituted are prepared by: (1) reacting R-Ph-COR 1 in the presence of Zn with Hal-C(B)(R 2 )-X 0 where X 0 is esterified carboxyl; (2) decarboxylating (3) isomerizing R-Ph-C(=R 1 1)-CHR 2 -X where R 1 1 is a divalent residue of aliphatic character in which the free valencies emanate from the same carbon atom; or (4) converting the CN group in to ...

Improved process for tetrafluorobenzoic acid.

Process for the preparation of new B-phenylated fatty-acids.

Manufactoring process of new substituted acids alcénoïques.

Method of preparation of prostaglandin.

VERFAHREN ZUR HERSTELLUNG LAGERSTABILER LAEVULINSAEURE

A process for the preparation of colour-stable levulinic acid by hydrolysis of acetyl succinates using aqueous mineral acids, where the starting materials are treated continuously with steam in countercurrent in a reactor cascade, the reaction being carried out at above the boiling point of the alcohol produced during the reaction or above the boiling point of the aqueous azeotrope produced.

SUBSTITUIERTE ALPHA-FLUORACRYLSAEUREPHENYLESTER

PROCEDURE FOR the PRODUCTION OF 2,2-DIMETHYL-3 (2 ', 2 ' - DIHALOGENVINYL) - CYCLOPROPAN-1-CARBONSAEUREESTERN

PROCEDURE FOR THE PRODUCTION OF A NEW PROSTAGLANDINDERIVATES

NEW FLUORHALTIGE CONNECTION, FLUORHALTIGES POLYMER AND PROCEDURE FOR THE PRODUCTION OF THE CONNECTION

PROCEDURE FOR the PRODUCTION of NEW 3 - (4-BIPHENYLYL) - BUTTER-SOUR, THEIR ESTERS, AMIDES AND SALTS

PROCEDURE FOR the PRODUCTION OF NEW ONE 4 (4-BIPHENYLYL) - 4-HYDROXY-BUTTERSAEUREAMIDEN

SUBSTITUTED OXIRANCARBONSAEUREN, PROCEDURE FOR YOUR PRODUCTION, YOUR USE AND IT CONTAINING DRUGS.

PROCEDURE FOR THE PRODUCTION OF STORABLE ONES LAEVULINSAEURE.

PROCEDURE FOR THE PRODUCTION OF TETRAFLUORBENZOESAEURE.

DERIVATIVES THE OMEGA DIALKYLIERTEN ALKANKARBONSAEUREN, PROCEDURE FOR YOUR PRODUCTION AND USE AS DRUGS.

Procedure for the production of the new anti-bioTIC around the Violamycin as well as its Aglycons

Procedure for the production of the new α (4-Biphenyloxy) - heptane acid and its salts

Procedure for the production of 2,4,5-Trichlorbenzoesäure

Preparation of perylene-3,4-dicarboxylic anhydrides

CHEMICAL PROCESSES AND PRODUCTS

11, DEOXY PGE DERIVATIVES

PREPARATION OF NOVEL VINYL ETHERS

DERIVATIVES OF 9-OXO-13-TRANS-PROSTENOIC ACID ESTERS

PHENYL PYRIMIDINES

A PROCESS FOR THE PRODUCTION OF METHACRYLIC ACID AND ITS DERIVATIVES AND POLYMERS PRODUCED THEREFROM

A process for the production of methacrylic acid is described. The process comprises the base catalysed decarboxylation of at least one or a mixture of dicarboxylic acids selected from itaconic, citraconic or mesaconic acid. The decarboxylation is carried out in the range greater than 240 and up to 275°C to provide high selectivity. The methacrylic acid product may be esterified to produce an ester. A method of preparing polymers or copolymers of methacrylic acid or methacrylic acid esters using the process is also described. Optionally, the process may be preceded with a decarboxylation and, if necessary, a dehydration step on a source of pre-acid such as citric acid or isocitric acid.

PHENYLACETIC ACID DERIVATIVES

VINYLCARBOXYLIC ACID DERIVATIVES

Compounds of the formula (I), wherein R1 is C3-C8cycloalkyl, halo-C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C6alkyl, halo- C3-C8cycloalkyl-C1-C6alkyl, -Si(R3)3, -S-R4, -SO2-R6 or -CO-R9; R2 is halogen, C1-C4alkyl or CF3, the substituents R2 being identical or different when n is 2; R3 each independently of the others is C1-C6alkyl, halo-C1-C6alkyl, C1-C6alkoxy or phenyl; R4 is aryl or heteroaryl each of which is unsubstituted or substituted; R6 is unsubstituted or substituted C1-C10alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C20-alkoxy, C2-C6alkenyloxy, C2-C6alkynyloxy, C1-C4alkylthio, aryl, aryloxy or aryl-thio, or is optionally substituted amino; R9 is hydroxy, unsubstituted or substituted C1-C10alkyl, C2-C6lakenyl, C2-C6alkynyl, C3-C8cycloalkyl, aryl or aryloxy, or is optionally substituted amino; R12 is hydrogen or unsubstituted or substituted C1-C10-alkyl; m is 1,3,5,7,9 or 11; n is 0, 1 or 2; X is fluorine or chlorine; and Y is hydrogen, fluorine or methyl; in free form or in salt form, ...

NEUROTROPHIC AND ANTIPROLIFERATIVE COMPOUNDS

Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate of general formula (I), wherein R1 is -CCH, -CH=CH2 or -CH2-CH3, R2 is a saturated, unsaturated, branched or unbranched C1-C30 alkyl group which is optionally substituted with a C3-C9 aliphatic or aromatic cyclohydrocarbon,or heterocyclic group. M is a hydrogen or a metal atom. Formula (I) is not 2-n-propyl-4-pentynoic acid (4-yn-VPA) or 2-n-propyl-4-pentenoic acid (4-en-VPA) and when R1 is -CH2-CH3, R2 is C5 to C30. This invention also provides a method of making the compounds of the invention. The compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.

Procédé pour la production d'acide benzoïque.

Verfahren zur Herstellung von Benzoesäure.

Verfahren zur Herstellung von -Ketocarbonsäuren

Verfahren zur Herstellung von Pyromellithsäure.

Procédé de préparation d'agents anti-inflammatoires

Verfahren zur Herstellung von a,B-Dihalogenacrylsäuren oder deren Salzen

Nouveau procédé de préparation d'esters et de nitriles de l'acide chrysanthémique

Procédé de préparation d'un nouvel acide dicarboxylique non saturé, transformable en pyrocine

Verfahren zur Herstellung einer neuen Aryloxyalkansäure und ihrer Salze

Verfahren zur Herstellung neuer Essigsäure-Derivate

Hypocholesterolaemic diphenoxyacetic acidderivs

Title acids of formula (I) (where each Y is identical and is CF3, p-Cl-phenyl or phenyl) and their salts with salt-forming cations which are useful as hypocholesterolaemics and hypolipaemics are prepd. by saponifying cpds, of formula (II) (where R is 1-4C alkyl) at a temperature at which partial decarboxylation occurs.

Verfahren zur Herstellung neuer Essigsäure-Derivate

Verfahren zur Herstellung neuer Essigsäure-Derivate

Verfahren zur Herstellung neuer Essigsäure-Derivate

Aryloxyalkanoic acids treatment of hyperlipaemia

... (A) Cmpd. (I) and salts (II) thereof (B) Cmpds. of general formula (III) where R1 = a hydrocarbon residue, pref. lower alkyl, cyclohexyl Ph, or Ph CH2. (C) Nitriles, amides, and imido-lower alkyl esters of III. (IV) III and Iv Intermediates for I and II I and II Hypolipaemics-long acting and of low toxicity. For peroral or reactal use at 50-500 mg/d. (a) Powdered p-phenylphenol (27.2g.) was dissolved in NaOEt (from 3.68g. Na) in EtOH (150ml.), followed by ethyl 2-bromoheptanoate (35g.), refluxed 7 h., evapd., dissolved in Et2O, and the Et2O washed with 0.5N NaOH until the alkali ceased to become hazy. The Et2O was then washed 3 X times 0.5N NaOH, with H2O, dried, and evapd., giving the pure ester. (b) This (10g.) was refluxed 1 h. with KOH (2.1g.) in MeOH (50 ml.), concd. to a syrup, dild. with H2O, and the clear soln. (if not clear, the insol. is extd. with Et2O), acidified with 2N-HCl, giving an oil which crystallised slowly. This was recryst. from MeOH-Aq. and from Me2CO - pet. spirit ...

Prepn of alpha, beta-dihaloacrylic acids or their - salts

A dihalomaleic acid (pref. di-Br-, di-Cl- or di-I-maleic acid) or an anhydride, acid salt, ester or hemiester thereof (I) is heated at 110-180 (pref. 120-140) degrees C in the presence of a solvent consisting of or containing H2O. Pref. the solvent is H2O or (only when (I) is dihalomaleic acid or an acid salt thereof) is an inert non-aqueous solvent e.g. alcohol, 2-8C ether, 3-8C ketone, 2-7C nitrile or dimethyl sulphoxide. Advantage is the comparative cheapness of starting material and the low temp.

VERFAHREN ZUR HERSTELLUNG SUBSTITUIERTER ALKENCARBONSAEUREN.

Mercapto carboxylic acid esters - used as odourisers and aromatisers in perfumes, soaps, foods, detergents

Mercapto-carboxylic acid esters (I) of formula:- (where R' is CC alkyl, alkenyl or alkadienyl group and R2 is a 3-9C alkyl or alkenyl group), may be prepd. by reacting R2-CH=CH-COOR' with H2S in presence of a basic catalyst. A pref. cpd. is ethyl-3-mercapto-j-Me-caproate which is prepd. by reacting ethyl-4-methyl-2-hexanoate with H2S.

VERFAHREN ZUR HERSTELLUNG NEUER UNGESAETTIGTER VERBINDUNGEN.

Procédé de préparation de dérivés de l'acide a-phényl-propinoique

Procédé de préparation de dérivés de l'acide a-phényl-propionique

Verfahren zur Herstellung von Phenoxy-alkancarbonsäuren

Verfahren zur Herstellung kosmetischer Erzeugnisse

Verfahren zur Herstellung von Vinylverbindungen

Procédé de fabrication de l'acide acrylique

Verfahren zur Herstellung neuer Essigsäure-Derivate

Analgesic anti-inflammatory alpha-phenyl fatty acids

Analgesic anti-inflammatory alpha-phenyl fatty acids.. M3A. Are new cmpds of formula (I) (where X is COOH or an ester or amide thereof; R is 1-cyclo-alkenyl opt. substd. by alkyl, alkoxy, halogen or CF3; R1 & R2 are H or a mono-valent aliphatic or araliphatic hydrocarbyl residue, or together form a similar bivalent residue); but excluding alpha-(p-(cyclohexenyl) phenyl)propionic acid. Prefd. cpds. include alpha-(p-(1-cyclopentenyl)propionic acid (II);.

Verfahren zur Herstellung neuer Diphenoxyacetamide

Nouveau procédé de préparation de la pyrocine

Verfahren zur Herstellung einer neuen Aryloxyalkansäure und ihrer Salze

Utilisation de dérivés oxygénés d'oléfines acycliques comme agents odoriférants

Verfahren zur Herstellung neuer a-Phenylcarbonsäuren

Analgesic anti-inflammatory cyclohexenylphenyl- - propionic acid

Analgesic anti-inflammatory cyclohexenylphenyl-propionic acid. M3A. Is a new cmpd. of formula (I) and is isolated in d- and 1-forms. It may be prepared e.g. from (where Y is a gp. convertible to COOH, esp. CN).

Analgesic anti-inflammatory cyclohexenylphenyl- - propionic acid

Analgesic anti-inflammatory cyclohexenylphenyl-propionic acid. M3A. Is a new cmpd. of formula (I) and is isolated in d- and 1-forms. It may be prepared e.g. from (where Y is a gp. convertible to COOH, esp. CN).

Verfahren zur Herstellung von 2,4,5-Trichlorbenzoesäure

Verfahren zur Herstellung neuer Essigsäure-Derivate

PESTICIDE MEANS, CONTAINING 2-SUBSTITUIERTE ISOVALERATE.

PROCEDURE FOR the PRODUCTION OF NEW ONE 4,5,6-TRINOR-3,7-INTER-M-PHENYLENPROSTAGLANDIN-VERBINDUNGEN.

Process for the preparation of an 8-azaprostaglandin

An 8-azaprostaglandin of formula: is prepared by saponifying, in an alcohol medium and using an alkali metal hydroxide, an ester of general formula: in which R represents a linear or branched alkyl containing 1 to 7 carbon atoms, and then the alkali metal salt thus formed is hydrolysed using a strong acid. The derivative thus prepared in a completely synthetic way can exist in the form of optical isomers, positional isomers or a mixture of these isomers. However, its chemical structure is simpler than that of PGE1 because the asymmetry of the 8 and 11 carbons is suppressed. The derivative of the invention has the properties of PGE1, in particular a more specific bronchodilatory activity than that of PGE1. It can be used especially in the treatment of asthma.

Process for the preparation of new cyclopentane derivatives

The derivatives of the cyclopentane of formula below are prepared by hydrolysis of a corresponding 5-ketal. In this formula, R<2> = aryl or heterocyclyl, n = 5 to 8, and: either A = alkylene, X = trans vinylene or ethylene, Y = carbonyl or hydroxymethylene and Z = direct bond or O or S atom, or A and Z = direct bonds, and X and Y are respectively ethylene and carbonyl, trans vinylene and carbonyl, or ethylene and hydroxymethylene. These compounds are active in particular against gastric acid secretion and for the cicatrisation of gastric ulcers. ...

Process for the preparation of substituted benzoylacrylanilides

Process for the preparation of 8-azaprostaglandins

... 8-Azaprostaglandins of formula: in which R represents methyl or ethyl, are prepared by reducing, in an inert medium, with a reducing agent such as sodium borohydride, a ketone of general formula: The derivatives thus prepared in a completely synthetic way can exist in the form of optical isomers, positional isomers or a mixture of these isomers. However, their chemical structure is simpler than that of PGE1 because the asymmetry of the 8 and 11 carbons is suppressed. The derivatives of the invention have the properties of PGE1, in particular a more specific bronchodilatory activity than that of PGE1. They can be used especially in the treatment of asthma.

MIXTURE WITH NEMATI CHARACTERISTICS.

PROCEDURE FOR THE PRODUCTION OF NEW PROSTANSAEUREDERIVATE.

PROCEDURE FOR THE PRODUCTION OF NEW PROSTANSAEUREDERIVATE.

ALCOHOL DERIVATIVES OF BETA, GAMMA [...] AND PHARMACEUTICAL COMPOSITIONS CONTAINING A COMPOUND [...].

METHOD OF PRODUCING METHACRYLIC ACID AND ITS DERIVATIVES AND POLYMERS, OBTAINED FROM THEM

METHOD OF PRODUCING METHACRYLIC ACID, ITS DERIVATIVES AND POLYMERS BASED ON METHACRYLIC ACID

A process for the production of (meth)acrylic acid and derivatives and polymers produced therefrom

Normal;heading 1;heading 2;heading 3;PROCESS FOR THE PRODUCTION OF METHACRYLIC ACID AND ITS DERIVATIVES AND POLYMERS PRODUCED THEREFROM

Method for preparing 2-valproic acid

NEW PHENYLPYRIMIDINES, THEIR METHOD OF PREPARATION AND THEIR ELECTRO-OPTICAL APPLICATION

PHARMACEUTICAL COMPOSITION CONTAINING ONE COMPOSES POLYPRENYLIQUE

Process for preparing and purifying fatty acids

There is provided a process for purifying a fatty acid, which process comprises reacting a fatty acid with a lithium salt in a first solution and under conditions to allow formation of a precipitate of a lithium salt of the fatty acid; isolating the precipitate; dissolving the precipitate in a second solution followed by separation of the organic and aqueous layers so formed; and evaporating the organic layer to isolate the purified fatty acid. There is also provided a process for increasing the length of a fatty acid, and the use of a lithium salt to purify a fatty acid.

Method of inhibiting polymerization and fouling in acrylic acid and acrylate processes

The method of inhibiting the polymerization of a mono-ethylenically unsaturated carboxylic acid, anhydride, ester or neutralized or partially neutralized salt, e.g., an acrylic acid or ester, in an aqueous solution and in the presence of oxygen, the method comprising the step of mixing with the aqueous solution an inhibitor comprising (i) at least 50 ppm of an N-oxyl compound, e.g., 4-hydroxy-TEMPO, and (ii) a manganese ion, the N-oxyl compound and manganese ion present in a N-oxyl compound to manganese ion weight ratio of 50:1 to less than 100:1. based on the mono-ethylenically unsaturated carboxylic acid, anhydride, ester or salt.

PROCESS FOR THE PRODUCTION OF METHACRYLIC ACID AND ITS DERIVATIVES AND POLYMERS PRODUCED THEREFROM

A process for the production of methacrylic acid is described. The process comprises the base catalysed decarboxylation of at least one or a mixture of dicarboxylic acids selected from itaconic, citraconic or mesaconic acid. The decarboxylation is carried out in the range greater than 240 and up to 275° C. to provide high selectivity. The methacrylic acid product may be esterified to produce an ester. A method of preparing polymers or copolymers of methacrylic acid or methacrylic acid esters using the process is also described. Optionally, the process may be preceded with a decarboxylation and, if necessary, a dehydration step on a source of pre-acid such as citric acid or isocitric acid. 1. A process for the production of methacrylic acid by the base catalysed decarboxylation of at least one dicarboxylic acid selected from itaconic , citraconic or mesaconic acid or mixtures thereof , wherein the decarboxylation is carried out at greater than 240 and up to 275° C.2. A process according to claim 1 , wherein the decarboxylation is in the temperature range between 245 and up to 275° C.3. A process according to claim 1 , wherein the dicarboxylic acid reactants and preferably the base catalyst are in aqueous solution.4. A process according to claim 1 , wherein the decarboxylation reaction is carried out at suitable pressures in excess of atmospheric pressure.5. A process according to claim 1 , wherein the base catalyst comprises a metal oxide claim 1 , hydroxide claim 1 , carbonate claim 1 , acetate (ethanoate) claim 1 , alkoxide claim 1 , hydrogencarbonate or salt of a decomposable di- or tri-carboxylic acid claim 1 , or a quaternary ammonium compound of one of the above claim 1 , or one or more amines.6. A process according to claim 1 , wherein the base catalyst is selected from one or more of the following: LiOH claim 1 , NaOH claim 1 , KOH claim 1 , Mg(OH) claim 1 , Ca(OH) claim 1 , Ba(OH) claim 1 , CsOH claim 1 , Sr(OH) claim 1 , RbOH claim 1 , NHOH claim 1 , LiCO ...

METHODS FOR SYNTHESIS OF OLEFINS AND DERIVATIVES

The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided. 2. The method of claim 1 , wherein said cross-metathesis transformation catalyst is a ruthenium catalyst bearing an N-heterocyclic carbene ligand.3. The method of claim 2 , wherein the ruthenium catalyst bearing an N-hetrocyclic carbine ligand is selected from the group consisting of[1,3 bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro[(2-(1-methylethoxy)phenyl)methylene]ruthenium;[1,3-bis(2-methylphenyl)-2-imidazolidinylidene]dichloro(benzylidene) (tricyclohexylphosphine)ruthenium(II);[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(3-methyl-2-butenylidene)(tricyclohexylphosphine)ruthenium(I); and[1,3-bis-(2,4,6 trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine) ruthenium.4. The method of claim 1 , wherein the ethylene is present as a gas.553.-. (canceled)55. The production system of claim 54 , wherein said genes encoding said metabolic modifications (a) fumABC claim 54 , zwf claim 54 , purU further comprises disruption of at least one gene selected from ackA-pta claim 54 , gdhA claim 54 , pntAB or ackA-pta claim 54 , yibO claim 54 , ythE.56. The production system of claim 54 , wherein said disruption comprises a deletion of at least one gene within said ...

PROCESS FOR THE PRODUCTION OF (METH)ACRYLIC ACID AND DERIVATIVES AND POLYERS PRODUCED THEREFROM

A method of extracting (meth)acrylic acid from an aqueous reaction medium into an organic phase in contact therewith is described. The aqueous reaction medium is formed from at least one base catalyst and at least one dicarboxylic acid selected from maleic, fumaric, malic, itaconic, citraconic, mesaconic, and citramalic acid or mixtures thereof in aqueous solution and contains the base catalysed decarboxylation products of the base catalysed reaction. The method includes either the addition of at least one of the said dicarboxylic acids and/or a pre-cursor thereof to the aqueous reaction medium to enhance the solvent extraction of the (meth)acrylic acid into the organic solvent or maintaining the level of base catalyst to dicarboxylic acid and/or pre-cursor at a sub-stoichiometric level during the extraction process. The method extends to a process of producing (meth)acrylic acid, its esters and polymers and copolymers thereof. 1. A method of extracting (meth)acrylic acid from an aqueous reaction medium , the aqueous reaction medium being formed from at least one base catalyst and at least one dicarboxylic acid selected from maleic , fumaric , malic , itaconic , citraconic , mesaconic , and citramalic acid or mixtures thereof in aqueous solution and containing the base catalysed decarboxylation products thereof including (meth)acrylic acid and/or (meth)acrylate base salt , the method comprising the steps of introducing an organic solvent to the said aqueous reaction medium for solvent extraction of the (meth)acrylic acid into an organic phase wherein the method is characterised in that there is added an additional amount of at least one of the said dicarboxylic acids and/or a pre-cursor thereof to the said aqueous reaction medium to enhance the solvent extraction of the (meth)acrylic acid into the organic solvent.2. A method according to claim 1 , wherein the concentration of (meth)acrylic acid in the aqueous phase extraction is at least 0.05 mol dm.3. A method ...

2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE

Compounds of the formula 1 2. The method according to wherein R is hydrogen claim 1 , methyl or ethyl.3. The method according to wherein the decarboxylation is carried out in a polar aprotic solvent at 75-85° C.4. The method according to wherein the compound of formula 1 is thermally decarboxylated at a temperature of 50-350° C. under flow conditions.5. An ester of the formula 4 obtained from the compound of formula 1 according to the method of .6. An ester of the formula 4 obtained from the compound of formula 1 according to the method of .8. The method according to wherein the metal salt is LiCl and/or MgCland the solvent is NMP.9. An acid of the formula 6 obtained from the compound of formula 1 claim 7 , according to the method of . The present application is a divisional application of co-pending U.S. Ser. No. 14/563,312, filed Dec. 8, 2014, which is a divisional application of co-pending United States Ser. No. 13/995,368, having a 35 USC 371 (c) date of Nov. 27, 2013, now U.S. Pat. No. 8,933,253, which is a national stage application of International Application No. PCT/EP2011/73550, filed 21 Dec. 2011, which claims the benefit of Great Britain Application No. 1021584.6, filed 21 Dec. 2010, which applications are incorporated herein by reference.The invention is concerned with organic compounds their preparation and use as intermediates in the synthesis of fragrance ingredients.Many fragrance ingredients that are used by perfumers in the creation of new and exciting fragrance accords are commodity ingredients, that is, they are non-proprietary and versions of the ingredients, which may differ in price and quality, and are available from many different suppliers. The uptake of a particular version of such ingredients by perfumers may be based on considerations of costs as well as on performance.3a,6,6,9a-tetramethyldodecahydronaphtho[2,1-b]furan 2, from which certain isomers or isomer mixtures are on the market, for example Ambrofix® (Givaudan), Ambroxan® (Kao), ...

PROCESS FOR PREPARING TAPINAROF

The present invention provides processes for the preparation of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3,5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same. 118.-. (canceled)20. The process of wherein X is Cl.21. The process of wherein the aromatizing comprises contacting the compound of Formula (II) or a salt thereof with quaternary ammonium salt in a solvent.22. The process of claim 21 , wherein the quaternary ammonium salt is tetraethylammonium chloride.24. The process of wherein the halogenating agent is selected from the group consisting of 1 claim 23 ,3-dichloro-5 claim 23 ,5-dimethylhydantoin; N-chlorosuccinimide; and trichloroisocyanuric acid.25. The process of claim 23 , wherein the halogenating is carried out in methanol and the halogenating agent is 1 claim 23 ,3-dichloro-5 claim 23 ,5-dimethylhydantoin.27. The process of claim 26 , wherein R is selected from the group consisting of methyl claim 26 , ethyl claim 26 , propyl claim 26 , or butyl.28. The process of claim 26 , wherein R is methyl or t-butyl.29. The process of claim 26 , wherein the cyclizing comprises contacting the compound of Formula (IV) or a salt thereof with potassium tert-butoxide in 2-methyltetrahydrofuran.31. The process of claim 30 , wherein the esterifying comprises heating the compound of Formula (V) or a salt thereof with aqueous hydrochloric acid in methanol.33. The process of claim 32 , wherein the decarboxylating comprises heating the compound of Formula (VI) or a salt thereof in the presence of triethylamine.35. The process of claim 34 , wherein each of Rand Ris ethyl.36. The process of claim 34 , wherein the hydrolyzing comprises treating the compound of Formula (VII) or a ...

Process for preparing azelaic acid

A process for preparing azelaic acid is disclosed. In particular, the process for preparing azelaic acid is an ozone free process. The process for preparing azelaic acid comprises a step of decarboxylation of tetra-carboxylic acid in the presence of a organic sulfonic acid. 2. The process of claim 1 , wherein the compound has alpha-protons is diethyl malonate.3. The process of claim 1 , wherein the pentane has two leaving groups bound to 1 and 5 carbon comprises 1 claim 1 ,5 di-halopentane or 1 claim 1 ,5 di-sulfonate pentane.4. The process of claim 1 , wherein the base comprises a alkali metal carbonate claim 1 , alkali metal alkoxide or alkali metal amide.5. The process of claim 4 , wherein the alkali metal alkoxide comprises sodium methoxide claim 4 , sodium ethoxide claim 4 , or potassium tert-butoxide.6. The process of claim 1 , wherein the decarboxylation of the tetra-carboxylic acid is performed between 100 and 150° C.7. The process of claim 1 , wherein the organic sulfonic acid comprises methanesulfonic acid claim 1 , p-toluenesulfonic acid claim 1 , benzenesulfonic acid or perfluorosulfonic acid.9. The process of claim 8 , wherein the compound has alpha-protons is di-tert butyl malonate or malonontrile.10. The process of claim 8 , wherein the pentane has two leaving groups bound to 1 and 5 carbon comprises 1 claim 8 ,5 di-halopentane or 1 claim 8 ,5 di-sulfonate pentane.11. The process of claim 8 , wherein the base comprises a alkali metal carbonate claim 8 , alkali metal alkoxide or alkali metal amide.12. The process of claim 11 , wherein the alkali metal alkoxide comprises sodium methoxide claim 11 , sodium ethoxide claim 11 , or potassium tert-butoxide.13. The process of claim 8 , wherein the decarboxylation of the tetra-carboxylic acid is performed between 100 and 150° C.14. The process of claim 8 , wherein the organic sulfonic acid comprises methanesulfonic acid claim 8 , p-toluenesulfonic acid claim 8 , benzenesulfonic acid or perfluorosulfonic acid. ...

Method Of Preparing Fused Ring Indeno Compounds

The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride. With some embodiments, the fused ring indeno compound is represented by the following Formula (I-A), the dienophile is represented by the following Formula (II-A), and the lactone compound is represented by the following Formula (III-A): 112-. (canceled)15. The method of wherein claim 14 , [{'sub': 20', '1', '10', '1', '10, 'the metal M of Formula (V) and Formula (VI) is independently selected from Bi, B, Al, Hf, Sc, Cu, Yb, Ti, Sn, Fe, Zn, Ag, Y, In, Nb and Mg, Ris selected from C-Clinear or branched alkyl, and C-Clinear or branched perfluoroalkyl, and X is selected from I, F, Cl, and Br, and'}, 'said solvent is selected from benzene, xylene, toluene, methylene chloride, chloroform, 1,2-dichloroethane, acetonitrile, nitromethane and combinations of two or more thereof., 'in said first step,'}16. The method of wherein said first step is conducted in the presence of an acid selected from alkyl sulfonic acid claim 13 , aryl sulfonic acid claim 13 , and combinations thereof.17. The method of wherein said acid is selected from p-toluene sulfonic acid claim 16 , dodecylbenzenesulfonic acid claim 16 , and combinations thereof.19. The method of wherein said protonic acid is selected from carboxylic acids claim 18 , sulfonic acids claim 18 , phosphoric acids claim 18 , hydrogen halides claim 18 , and combinations thereof.21. The method of wherein claim 20 ,{'sub': '6', 'Ring-A, for Formula (I-E), Formula (III-A), and Formula (VIII-A), is C-aryl,'}{'sup': '1', 'sub': 1', '6', '3', '7', '1', '8', '10, 'R, for Formula (I-E), Formula (III-A), and Formula (VIII-A), for each n is independently selected from hydrogen, C-Clinear or branched alkyl, C-Ccycloalkyl, C-Chaloalkyl, fluoro, chloro, and —O—R′,'}{'sup': 4', '5, 'claim-text': hydrogen;', {'sub': 1', '6, 'C-Clinear ...

RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE

Systems and methods for the production of malonate in recombinant host cells. 115-. (canceled)16. A malonyl-CoA hydrolase having at least 75% identity with SEQ ID NO: 9.17. The malonyl-CoA hydrolase of that is a Pseudomonas fulva protein further comprising the mutation E95N.18Pichia kudriavzevii. A recombinant host cell that comprises one or both of:{'i': 'Pseudomonas fulva', 'a heterologous malonyl-CoA hydrolase having at least 75% identity with SEQ ID NO: 9, and'}{'i': 'Saccharomyces cerevisiae', 'a heterologous (Sc) aldehyde dehydrogenase (ALD) selected from Sc ALD 2 to 6.'}19Pichia kudriavzeviiPseudomonas fulva. The recombinant host cell of that comprises a heterologous malonyl-CoA hydrolase having at least 75% identity with SEQ ID NO: 9.20Pichia kudriavzeviiSaccharomyces cerevisiae. The recombinant host cell of that comprises a heterologous aldehyde dehydrogenase selected from Sc ALD 2 to 6.21Pichia kudriavzeviiPseudomonas fulvaSaccharomyces cerevisiae. The recombinant host cell of that comprises a heterologous malonyl-CoA hydrolase having at least 75% identity with SEQ ID NO: 9 and a heterologous aldehyde dehydrogenase selected from Sc ALD2 to 6.22Pichia kudriavzeviiSaccharomyces cerevisiae. The recombinant host cell of that comprises the heterologous aldehyde dehydrogenase Sc ALD 6.23Pichia kudriavzeviiSaccharomyces cerevisiae. The recombinant host cell of that comprises the heterologous aldehyde dehydrogenase Sc ALD 6.24Pichia kudriavzeviiSaccharomyces cerevisiae. The recombinant host cell of that comprises the heterologous aldehyde dehydrogenase Sc ALD 6.25Pichia kudriavzevii. The recombinant host cell of that further comprises a heterologous acetyl-CoA carboxylase.26. A method of producing malonic acid or a salt thereof comprising culturing the host cell of under conditions that result in the production of malonic acid or the salt thereof.27. The method of claim 26 , wherein the salt is a sodium claim 26 , ammonium claim 26 , or another monovalent cation ...

Method For Preparing Substituted Phenylacetic Acid Derivative

The invention belongs to the pharmaceutical manufacturing field, which relates to a novel process for the preparation of substituted phenylacetic acids derivatives, especially relates to the preparation of 2-(4-(2-oxocyclopentyl)phenyl)propanoic acid. The process for the preparation of the precursor form of loxoprofen which use 1,4-di-halobenzyl compounds or disubstituted benzyl compounds as starting material, is through the substitution reaction of cyclopentanone groups or its precursor compounds. 6. Formula G and formula Gof . Wherein the preparation method of loxoprofen include the decarboxylation step.7. According to claim 6 , the sequence of decarboxylation is from the first step to the second step and the third step.12. (canceled)13. (canceled) This application claims priority of Chinese patent application submitted to the Chinese Patent Office on Sep. 7, 2017, with the application number 201710800788.8, and entitled “Preparation Method For Substituted Phenylacetic Acid Derivatives”. All of its contents are incorporated in this application by reference.The invention belongs to the field of pharmaceutical manufacturing in reference to a preparation method of substituted phenylacetic acid derivatives, specifically relates to 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoic acid.Substituted phenylacetic acid derivatives are disclosed in U.S. Pat. No. 4,161,538, with good pharmaceutical activity of anti-inflammatory, analgesic and antipyretic. the structure is shown as follows:When A is oxygen and n=1 meanwhile and R is methyl group, in the above general formula structure, the representative substituted phenylacetic acid is loxoprofen. The structure is shown as follows:Loxoprofen is a non-steroidal anti-inflammatory type drug of with propionic acid moiety. The propionic acid derivatives drug family also include ibuprofen and naproxen et al. The loxoprofen has been launched in Brazil, Mexico and Japan in the form of sodium salt wherein honored by Sankyo. The trade ...

BIO-BASED METHACRYLIC ACID AND OTHER ALKENOIC-DERIVED MONOMERS VIA CATALYTIC DECARBOXYLATION

A novel method for the catalytic selective decarboxylation of a starting material to produce an organic acid is disclosed. According to at least one embodiment, the method may include placing a reaction mixture into a reaction vessel, the reaction mixture including a solvent, a starting material, and a catalyst, subjecting the reaction mixture to a predetermined pressure and temperature, and allowing the reaction to continue for 1-3 hours. The starting material may be at least one of a dicarboxylic acid, a tricarboxylic acid, and an anhydride of a dicarboxylic or tricarboxylic acid. As an exemplary embodiment, itaconic acid may be a starting material and the organic acid may be methacrylic acid. The predetermined temperature may be 250° C. or less, and the reaction pressure may be less than 425 psi. Further, a polymerization inhibitor may be used. 1: A method for the selective production of an organic acid , comprising:placing a reaction mixture into a first reaction vessel, the reaction mixture comprising a first solvent, a starting material, and a catalyst;pressurizing the first reaction vessel to a predetermined pressure;heating the reaction mixture to a predetermined temperature; andmaintaining the predetermined temperature for a predetermined reaction time,wherein the starting material is a at least one of a dicarboxylic acid, a tricarboxylic acid, and an anhydride of a dicarboxylic or tricarboxylic acid.2: The method of claim 1 , wherein the organic acid has a chemical formula of CHCRCOOH claim 1 , wherein R is either an H or a CH.3: The method of claim 1 ,wherein the organic acid is methacrylic acid, andwherein the starting material is one of itaconic acid, citraconic acid, mesaconic acid, citric acid, and a combination thereof.4: The method of claim 1 ,wherein the organic acid is acrylic acid, andwherein the starting material is one of fumaric acid, maleic acid, maleic anhydride, and a combination thereof.5: The method of claim 1 , wherein the predetermined ...

PROCESS FOR THE PRODUCTION OF METHACRYLIC ACID AND ITS DERIVATIVES AND POLYMERS PRODUCED THEREFROM

A process for the production of methacrylic acid or esters thereof by the base catalysed decarboxylation of at least one dicarboxylic acid selected from itaconic, citraconic or mesaconic acid or mixtures thereof in an aqueous reaction medium is described. The decarboxylation is carried out at a temperature in the range from 200° C. and up to 239° C. The methacrylic acid is isolated from the aqueous reaction medium by a purification process which does not include introducing an organic solvent to the aqueous reaction medium for solvent extraction of the methacrylic acid into an organic phase. A method of preparing polymers or copolymers of methacrylic acid or methacrylic acid esters is also described. 1. A process for the production of methacrylic acid or esters thereof by the base catalysed decarboxylation of at least one dicarboxylic acid selected from itaconic , citraconic or mesaconic acid or mixtures thereof in an aqueous reaction medium , wherein the decarboxylation is carried out at a temperature in the range from 200° C. and up to 239° C. and wherein the methacrylic acid is isolated from the aqueous reaction medium by a purification process which does not include introducing an organic solvent to the said aqueous reaction medium for solvent extraction of the methacrylic acid into an organic phase.2. A method or process according to any claim 1 , wherein the dicarboxylic acid(s) reactant(s) or the source of pre-acids thereof are exposed to the reaction conditions for a time period of between about 75 seconds and 3000 seconds.3. A process for the production of methacrylic acid by the base catalysed decarboxylation of at least one dicarboxylic acid selected from itaconic claim 1 , citraconic or mesaconic acid or mixtures thereof claim 1 , wherein the decarboxylation is carried out in the temperature range between 200 and 239° C. and the dicarboxylic acid(s) reactant(s) are exposed to the reaction conditions for a time period of at least 80 seconds.4. A process ...

ORGANIC ACIDS FROM HOMOCITRATE AND HOMOCITRATE DERIVATIVES

This disclosure relates to methods for converting homocitric acid to adipic acid, and more particularly to methods of using metal catalysts to catalyze the conversion of homocitric acid to adipic acid. 1. A method for making adipic acid , or a salt or ester thereof , the method comprising contacting homocitric acid , or a salt , ester , or lactone thereof , with a metal catalyst.6. A method for making 2-ethylsuccinic acid , or a salt or ester thereof , the method comprising contacting homocitric acid , or a salt , ester , or lactone thereof , with a metal catalyst.11. A method for making 2-methylpentanedioic acid , or a salt or ester thereof , the method comprising contacting homocitric acid , or a salt , ester , or lactone thereof , with a metal catalyst.16. A method for making a composition comprising two or more compounds selected from the group consisting of: adipic acid , 1 ,2 ,4-butanetricarboxylic acid , 2-ethylsuccinic acid , and 2-methylpentanedioic acid , or a salt or ester thereof , the method comprising contacting homocitric acid , or a salt , ester , or lactone thereof , with a metal catalyst.21. The method of any one of - , wherein the metal catalyst is a heterogeneous catalyst.22. The method of any one of - , wherein the metal catalyst comprises a metal selected from the group consisting of Ni , Pd , Pt , Re , Ag , Au , Cu , Zn , Rh , Ru , Bi , Fe , Co , Os , Ir , V , and mixtures of two or more thereof.23. The method of any one of - , wherein the metal catalyst comprises a metal selected from the group consisting of Pd and Pt.24. The method of claim 23 , wherein the metal catalyst comprises Pd.25. The method of any one of - claim 23 , wherein the metal catalyst is a bimetallic catalyst.26. The method of claim 25 , wherein the metal catalyst comprises Pd and Cu.27. The method of any one of - claim 25 , wherein the metal catalyst is a nanocatalyst.28. The method of any one of - claim 25 , wherein the metal catalyst is a supported catalyst.29. The ...

PROCESS FOR PREPARING TAPINAROF

The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same. 3. A process for preparing a compound of claim 1 , comprising crystallizing a compound of Formula (I) using methanol and water.4. The process of claim 3 , wherein the process comprises seeding.5. The compound of prepared by a process comprising crystallizing a compound of Formula (I) using methanol and water.6. A pharmaceutical composition comprising a compound of and a pharmaceutically acceptable excipient.7. A pharmaceutical composition comprising a compound of and a pharmaceutically acceptable excipient. The present application is a Continuation of U.S. application Ser. No. 16/849,346, filed Apr. 15, 2020, which is a Continuation of U.S. application Ser. No. 16/189,268, filed Nov. 13, 2018, now U.S. Pat. No. 10,647,649, which claims benefit of and priority to U.S. Provisional No. 62/584,192 entitled “PROCESS,” filed Nov. 10, 2017, the contents of which are herein incorporated by reference in their entirety.Some embodiments of the present invention provides a processes for the preparation of the compound of Formula (I) or a salt thereof and to novel intermediates used thereinSome embodiments of the present invention describe a compound of Formula (IIa) or a salt thereofand processes for preparing same.Some embodiments of the present invention describe a compound of Formula (IVa) or a salt thereofand processes for preparing same.Some embodiments of the present invention describe a compound of Formula (V) or a salt thereofand processes for preparing same.Some embodiments of the present invention describe a ...

METHOD FOR SYNTHESIZING NOVEL COMPOUNDS DERIVED FROM 3-HYDROXY-CYLOPENTYL ACETIC ACID

The present invention relates to compounds of formula (I): 2. The process as claimed in for preparing a compound of formula (I) , wherein R1 is as defined in , andR2 denotes a linear, saturated hydrocarbon-based radical containing 3 to 12 carbon atoms, substituted with 1 to 3 groups, which may be identical or different, chosen from —OR31, —NHR31, —COOR31, —OCOR31 and halogens, with R31 representing a hydrogen atom, a phenyl radical or a linear or branched, saturated or unsaturated alkyl radical containing 1 to 4 carbon atoms, orR2 denotes a radical chosen from a cyclic, saturated hydrocarbon-based radical containing 5 to 7 carbon atoms, possibly substituted with 1 to 3 groups, which may be identical or different, chosen from —OR31, —NHR31, —COOR31, —OCOR31 and halogens, with R31 representing a hydrogen atom, a phenyl radical or a linear or branched, saturated or unsaturated alkyl radical containing 1 to 4 carbon atoms;R2 denotes a branched, saturated hydrocarbon-based radical containing 3 to 12 carbon atoms, optionally substituted with 1 to 3 groups, which may be identical or different, chosen from —OR31, —NHR31, —COOR31, —OCOR31 and halogens, with R31 representing a hydrogen atom, a phenyl radical or a linear or branched, saturated or unsaturated alkyl radical containing 1 to 4 carbon atoms.4. The process as claimed in for preparing a compound of formula (I) , wherein R1 is as defined in , and R2 denotes a radical —Ar—R22 with Ar being a phenyl or pyridyl aromatic nucleus and{'sub': 2', '2', '3, 'R22 represents a substituent of the aromatic nucleus Ar chosen from hydrogen, —OR′, —NO, —F, —Br, —NH, —CFand —R′, with R′ representing a hydrogen atom, a linear, branched or cyclic, saturated hydrocarbon-based radical containing 1 to 4 carbon atoms or a phenyl radical.'}6. The process as claimed in for preparing a compound of formula (I) , wherein R1 is as defined in , and R2 is a radical —R24-NH—R34 with R24 representing a linear , saturated divalent hydrocarbon-based ...

PROCESS FOR PREPARING TAPINAROF

The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same. 2. The process according to in which X is Cl and the process step (a)(i) is carried out using a chlorination reagent selected from the group consisting of 1 claim 1 ,3-dichloro-5 claim 1 ,5-dimethylhydantoin claim 1 , N-chlorosuccinimide and trichloroisocyanuric acid.3. The process according to wherein the conversion step (a)(ii) is carried out in the presence of an additive reagent which is a quaternary ammonium salt.4. The process according to wherein the additive reagent is a quaternary ammonium chloride salt.5. The process according to wherein the quaternary ammonium chloride salt is selected from the group consisting of benzyltriethylammonium chloride claim 4 , tetrabutylammonium chloride claim 4 , tetraethylammonium chloride claim 4 , and tetramethylammonium chloride.6. The process according to wherein the conversion is carried out in a solvent selected from the group consisting of acetonitrile claim 3 , toluene claim 3 , 2-methyl tetrahydrofuran claim 3 , isopropyl acetate claim 3 , acetone and methyl isobutyl ketone.8. The process according to which comprises a decarboxylation in the presence of a base.9. The process according to wherein the base is triethylamine.10. The process according to wherein esterification is performed using methanol and hydrochloric acid.11. The process according to wherein cyclization is performed using potassium tert-butoxide.12. The process according to wherein the compound of Formula (III) or a salt thereof is acidified and isolated by precipitation with ...

METHODS FOR THE SYNTHESIS OF OLEFINS AND DERIVATIVES

The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided. 172.-. (canceled)73. A non-naturally microbial organism comprising a set of metabolic modifications obligatorily coupling fumaric acid production to growth of the non-naturally microbial organism , the set of metabolic modifications comprising disruption of at least one gene encoding an enzyme catalyzing reactions selected from the group consisting of:(1) Fumarase (FUM), Phosphogluconate dehydrogenase (PGDH), Formyltetrahydrofolate hydrolase (FTHFD) and(2) Fumarase (FUM), Phosphogluconate dehydrogenase (PGDH), Serine hydroxymethyl transferase (GHMT2) or an ortholog thereof, which confer stable growth-coupled production of fumaric acid.74. The non-naturally occurring microbial organism of claim 73 , wherein the reactions encoding the metabolic modifications further comprises disruption of at least one gene selected from a set encoding enzyme reactions selected from the group consisting of reactions:(1) Fumarase (FUM), Phosphogluconate dehydrogenase (PGDH), Formyltetrahydrofolate hydrolase (FTHFD), Acetate kinase (ACKr)(2) Fumarase (FUM), Phosphogluconate dehydrogenase (PGDH), Formyltetrahydrofolate hydrolase (FTHFD), Glutamate dehydrogenase (GLUDy);(3) Fumarase (FUM), Phosphogluconate dehydrogenase (PGDH), ...

Synthesis of Azelaic Acid

This invention concerns a method of synthesizing Azelaic Acid. Particular reference is made to providing a new synthetic process for preparing azelaic acid in large scale with high purity (e.g., >99.7% with any individual impurity not more than 0.1%), which can be used as an active pharmaceutical ingredient. 1. A process for manufacturing azelaic acid comprising the step of:(a) decarboxylating heptane-1,1,7,7-tetracarboxylic acid with an organic base;thereby forming azelaic acid.2. (canceled)3. The process of claim 1 , wherein the organic base is triethylamine claim 1 , trimethylamine claim 1 , methylamine claim 1 , di-isopropyl ethylamine claim 1 , diethylamine claim 1 , propylamine claim 1 , butylamine claim 1 , tripropylamine claim 1 , ethylmethylamine claim 1 , ethylamine claim 1 , diethylmethylamine claim 1 , phenylamine claim 1 , alanine claim 1 , aniline claim 1 , ammonia claim 1 , dimethylaminopyridine or pyridine.4. The process of claim 1 , wherein the organic base is triethylamine.5. The process of claim 1 , wherein the organic base is at a molar/molar ratio of bases with respect to carboxylic acids from about 0.6 to about 2.6. The process of claim 1 , wherein the decarboxylation is performed using a solvent having a boiling temperature of at most about 200° C.7. The process of claim 1 , wherein the solvent is toluene claim 1 , tetrahydrofuran claim 1 , methyl tert-butyl ether claim 1 , dimethylsulfoxide claim 1 , acetonitrile claim 1 , 1 claim 1 ,2-dimethoxyethane claim 1 , dioxane claim 1 , benzene claim 1 , xylenes claim 1 , methyl t-butyl ether claim 1 , methylene chloride claim 1 , chloroform claim 1 , methyl ethyl ketone claim 1 , methyl isobutyl ketone claim 1 , acetone claim 1 , acetonitrile claim 1 , benzene claim 1 , N claim 1 ,N-dimethylformamide claim 1 , N claim 1 ,N-dimethylacetamide claim 1 , N-methylpyrrolidinone claim 1 , hexane claim 1 , heptane claim 1 , or xylene.8. The process of claim 1 , wherein the decarboxylation is performed at a ...

PROCESS FOR THE PRODUCTION OF METHACRYLIC ACID

Disclosed is a method of making methacrylic acid, or a carboxylic derivative thereof, from itaconic acid, isomers, or precursors thereof. A starting material comprising an acid selected from the group consisting of itaconic acid, citraconic acid, mesaconic acid, citric acid, aconitic acid, isocitric acid and mixtures thereof, is subjected to contact with 0.1 eq. to 3.0 eq. of a base, at a temperature of 150° C. to 350° C., under the influence of a transition metal-containing heterogeneous catalyst. A better yield at lower temperatures is achieved. 1. A method of making methacrylic acid , or a salt thereof , by subjecting a starting material comprising an acid selected from the group consisting of itaconic acid , citraconic acid , mesaconic acid , citric acid , aconitic acid , isocitric acid and mixtures thereof , to contact with 0.1 eq. to 3.0 eq. of a base , at a temperature of 150° C. to 350° C. , under the influence of a transition metal-containing catalyst.2. A method according to claim 1 , wherein the catalyst is a heterogeneous catalyst.3. A method according to claim 2 , wherein the catalyst comprises a transition metal in a metallic or salt form carried by a support.4. A method according to claim 3 , wherein the support is selected from the group consisting of alumina claim 3 , carbon claim 3 , barium sulfate claim 3 , and silica.5. A method according to or claim 3 , wherein a transition metal is present in the metallic form.6. A method according to claim 1 , wherein the transition metal-containing catalyst includes one or more elements from groups 6 claim 1 , 7 claim 1 , 8 claim 1 , 9 claim 1 , 10 claim 1 , and 11 of the Periodic Table of Elements.7. A method according to claim 6 , wherein the transition metal is selected from the group consisting of rhodium claim 6 , nickel claim 6 , palladium claim 6 , platinum claim 6 , gold claim 6 , and tungsten.8. A method according to any one of claim 6 , or claim 6 , wherein the temperature is in a range of from 200° ...

ALTERNATIVE PATHWAYS TO ADIPIC ACID BY COMBINED FERMENTATION AND CATALYTIC METHODS

Processes process for producing adipate or adipic acid using biological pathways and chemical catalyzes are disclosed. Homocitric acid may be a substrate in reaction pathways leading to adipic acid or a salt thereof. 1. A method for producing adipate or adipic acid comprising:a) condensing 2-ketoglutaric acid or salt thereof with acetyl-CoA to form homocitric acid or a salt thereof;b) converting homocitric acid or a salt thereof to adipate or adipic acid by at least one chemical reaction; andc) optionally, isolating adipate or adipic acid.9. The process of claim 1 , further comprising a heterogeneous catalyst system claim 1 , wherein the heterogeneous catalyst system comprises:a) at least one unsupported or supported solid acid catalyst wherein the solid acid catalyst is selected from the group consisting of (1) heterogeneous heteropolyacids and their salts, (2) natural clay minerals, (3) cation exchange resins, (4) metal oxides, (5) mixed metal oxides, (6) metal salts and (7) combinations of groups 1 to 6; andb) at least one unsupported or supported hydrogenation catalyst wherein the hydrogenation catalyst is selected from metals from the group consisting of nickel, copper, chromium, cobalt, rhodium, ruthenium, rhenium, osmium, iridium, platinum, palladium, platinum black, compounds thereof, and combinations thereof.12. The method of claim 1 , wherein the chemical catalyst comprises:a) at least one unsupported or supported solid acid catalyst wherein the solid acid catalyst is selected from the group consisting of (1) heterogeneous heterogeneous and their salts, (2) natural clay minerals, (3) cation exchange resins, (4) metal oxides, (5) mixed metals oxides, (6) metal salts and (7) combinations thereof; andb) at least one unsupported or supported hydrogenation catalyst wherein the hydrogenation catalyst is selected from metals from the group consisting of nickel, copper, chromium, cobalt, rhodium, ruthenium, rhenium, osmium, iridium, platinum, palladium, platinum ...

Process for the catalytic decarboxylative cross-ketonization of aryl and aliphatic carboxylic acid

The present invention pertains to a process for the cross-ketonization (Piria reaction) between an aryl carboxylic acid and an aliphatic carboxylic acid using a metal-based compound and a slight or a moderate excess of aryl carboxylic acid. A good selectivity, up to 99 mol %, can be achieved. The aryl aliphatic ketone can be used for the preparation of surfactants and other downstream products.

METHOD FOR PREPARING 1,3-CYCLOHEXANEDICARBOXYLIC ACID

The present invention relates to a method for preparing 1,3-cyclohexanedicarboxylic acid capable of exhibiting excellent activity, of enhancing the reaction efficiency and economic efficiency by using a catalyst having improved durability under the reaction conditions of high temperature and strong acid, of achieving excellent conversion rates by allowing most of reactants to participate in the reaction, and of obtaining products having high purity while minimizing by-products within a shorter period of time. The method for preparing 1,3-cyclohexanedicarboxylic acid may include: reducing isophthalic acid in the presence of a metal catalyst fixed to a silica support and containing a palladium (Pd) compound and a copper (Cu) compound in a weight ratio of 1:0.1 to 0.5. 1. A method for preparing 1 ,3-cyclohexanedicarboxylic acid comprising: reducing isophthalic acid in the presence of a metal catalyst fixed to a silica support and containing a palladium (Pd) compound and a copper (Cu) compound in a weight ratio of 1:0.1 to 0.5.2. The method for preparing 1 claim 1 ,3-cyclohexanedicarboxylic acid of claim 1 , wherein the silica support contained in the metal catalyst has a specific surface area of 100 m/g to 500 m/g.3. The method for preparing 1 claim 1 ,3-cyclohexanedicarboxylic acid of claim 1 , wherein the total pore volume of the silica support contained in the metal catalyst is be 0.5 cm/g to 2 cm/g.4. The method for preparing 1 claim 1 ,3-cyclohexanedicarboxylic acid of claim 1 , wherein the average pore diameter of the silica support contained in the metal catalyst is 80 Å to 200 Å.5. The method for preparing 1 claim 1 ,3-cyclohexanedicarboxylic acid of claim 1 , wherein the metal catalyst includes 0.1% to 10% by weight of the palladium (Pd) compound relative to the silica support.6. The method for preparing 1 claim 1 ,3-cyclohexanedicarboxylic acid of claim 1 , wherein the step of reducing isophthalic acid includes contacting the isophthalic acid with hydrogen ...

Production Of Terephthalic Acid Via Reductive Coupling Of Propiolic Acid Or Propiolic Acid Derivatives

A method of making terephthalic acid via reductive coupling of two molecules of propiolic acid or propiolic acid derivatives is presented. The reductive coupling can be catalyzed by compounds comprising metals, and propiolic acid or propiolic acid derivatives can be produced from acetylene and carbon dioxide. At least 4 of the 8 carbons in the terephthalic acid are non-fossil-derived. 1. A method of making terephthalic acid comprising reductive coupling of two molecules of propiolic acid or propiolic acid derivatives followed by reaction with ethylene and dehydrogenation.2. The method of claim 1 , wherein said reductive coupling comprises a catalyst claim 1 , and wherein said catalyst comprises a metal.3. The method of claim 1 , wherein said ethylene is non-fossil-derived.4. The method of claim 1 , wherein said propiolic acid or propiolic acid derivatives are produced by reaction of acetylene and carbon dioxide.5. The method of claim 4 , wherein said carbon dioxide is non-fossil-derived.6. The method of claim 5 , wherein said carbon dioxide is a by-product of an ethanol fermentation facility.7. The method of claim 4 , wherein said acetylene is non-fossil-derived.8. The method of claim 1 , wherein at least 4 of the 8 carbons in said terephthalic acid are non-fossil-derived.9. A method of making terephthalic acid comprising reductive coupling of two molecules of propiolic acid or propiolic acid derivatives followed by reaction with propiolic acid or propiolic acid derivatives claim 1 , and decarboxylation.10. The method of claim 9 , wherein said reductive coupling comprises a catalyst claim 9 , and wherein said catalyst comprises a metal.11. The method of claim 9 , wherein said propiolic acid or propiolic acid derivatives are produced by reaction of acetylene and carbon dioxide.12. The method of claim 11 , wherein said carbon dioxide is non-fossil-derived.13. The method of claim 12 , wherein said carbon dioxide is a by-product of an ethanol fermentation facility.14. ...

METHOD FOR PRODUCING ACETIC ACID

A method for producing acetic acid includes subjecting an acetic acid solution to an acetic anhydride decreasing treatment. The acetic acid solution is present typically in, or downstream from, a distillation column () of acetic acid production equipment (X), includes acetic acid in a concentration of 90 mass percent or more, acetic anhydride, and water, and is in such a state that an equilibrium concentration of acetic anhydride is higher than an acetic anhydride concentration. The acetic anhydride decreasing treatment includes at least one of water concentration increasing and temperature lowering so as to bring the acetic acid solution into such a state that the equilibrium concentration of acetic anhydride is lower than the acetic anhydride concentration. The acetic acid production method is suitable for yielding a high-purity acetic acid product. 1. A method for producing acetic acid , the method comprising: acetic acid in a concentration of 90 mass percent or more;', 'acetic anhydride; and', 'water,', 'the acetic acid solution being in such a state that an equilibrium concentration of acetic anhydride is higher than an acetic anhydride concentration; and, 'preparing an acetic acid solution comprisingsubjecting the acetic acid solution to an acetic anhydride decreasing treatment comprising at least one of water concentration increasing and temperature lowering, to bring the acetic acid solution into such a state that the equilibrium concentration of acetic anhydride is lower than the acetic anhydride concentration.2. The method according to for producing acetic acid claim 1 ,wherein a catalyst capable of functionally promoting acetic anhydride hydrolysis is present in the acetic acid solution during the acetic anhydride decreasing treatment.3. The method according to for producing acetic acid claim 2 ,wherein the catalyst comprises at least one substance selected from the group consisting of Broensted acids, Lewis acids, corrodible metals, ion exchange resins, ...

PROCESS FOR THE PRODUCTION OF (METH)ACRYLIC ACID AND DERIVATIVES AND POLYMERS PRODUCED THEREFROM

A method of extracting (meth)acrylic acid from an aqueous reaction medium into an organic phase in contact therewith is described. The aqueous reaction medium is formed from at least one base catalyst and at least one dicarboxylic acid selected from maleic, fumaric, malic, itaconic, citraconic, mesaconic, and citramalic acid or mixtures thereof in aqueous solution and contains the base catalysed decarboxylation products of the base catalysed reaction. The method includes either the addition of at least one of the said dicarboxylic acids and/or a pre-cursor thereof to the aqueous reaction medium to enhance the solvent extraction of the (meth)acrylic acid into the organic solvent or maintaining the level of base catalyst to dicarboxylic acid and/or pre-cursor at a sub-stoichiometric level during the extraction process. The method extends to a process of producing (meth)acrylic acid, its esters and polymers and copolymers thereof. 1. A method of extracting (meth)acrylic acid from an aqueous reaction medium , the aqueous reaction medium being formed from at least one base catalyst and at least one dicarboxylic acid selected from maleic , fumaric , malic , itaconic , citraconic , mesaconic , and citramalic acid or mixtures thereof in aqueous solution and containing the base catalysed decarboxylation products thereof including (meth)acrylic acid and/or (meth)acrylate base salt , the method comprising the steps of introducing an organic solvent to the said aqueous reaction medium for solvent extraction of the (meth)acrylic acid into an organic phase wherein the method is characterised in that there is added an additional amount of at least one of the said dicarboxylic acids and/or a pre-cursor thereof to the said aqueous reaction medium to enhance the solvent extraction of the (meth)acrylic acid into the organic solvent.2. A method according to claim 1 , wherein the concentration of (meth)acrylic acid in the aqueous phase extraction is at least 0.05 mol dm.3. A method ...

Reactive distillation process/equipment for fatty acid ester hydrolysis to produce carboxylic acid and alcohol

Provided are processes and products of manufacture that provide a green solution to the hydrolysis of C8/C10 methyl ester to fatty acids. Provided are reactive distillation processes for producing an aliphatic acid and an alcohol as hydrolysis products. Provided are processes and products of manufacture encompassing the hydrolysis of fatty acid alkyl esters to an aliphatic acid and an alcohol by a reactive distillation process. Provided are processes and products of manufacture useful for equilibrium-limited reactions and for the separation of azeotropic mixtures. Provided are reactive distillation products of manufacture and processes for alkyl alkanoate hydrolysis comprising a reaction column comprising a rectifying rectifying zone for further distillation, a reaction zone, and a stripping zone wherein products are separated from reaction mixtures, where a water stream and fatty acid alkyl ester stream can be fed into the reaction section.

2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE

Compounds of the formula 1 2. The compound according to wherein R is methyl.3. The compound according to wherein R is ethyl.7. The method according to wherein the organocatalyst is selected from the group consisting of ammonium salts of carboxylic acids claim 6 , ammonium salts of polycarboxylic acids claim 6 , and amine components selected from the group consisting of ammonia claim 6 , primary amines claim 6 , secondary amines claim 6 , polyamines claim 6 , amino acids and peptides.8. The method according to wherein the solvent or solvent system forms an azeotrope with water claim 6 , which is constantly removed from the reaction mixture by distillation.9. The method according to wherein the condensation reaction is carried out at about 60-95° C.10. The method according to wherein the solvents are selected from cyclohexane claim 6 , benzene claim 6 , toluene claim 6 , iso-propanol and tert-butanol. The present application is a continuation of co-pending U.S. Ser. No. 14/854,705, filed Sep. 15, 2015, which is a divisional application of U.S. Ser. No. 14/563,312, filed Dec. 8, 2014, now U.S. Pat. No. 9,163,000, which is a divisional application of U.S. Ser. No. 13/995,368, having a 35 USC 371 (c) date of Nov. 27, 2013, now U.S. Pat. No. 8,933,253, which is a national stage application of International Application No. PCT/EP2011/73550, filed Dec. 21, 2011, which claims the benefit of Great Britain Application No. 1021584.6, filed Dec. 21, 2010, which applications are incorporated herein by reference.The invention is concerned with organic compounds their preparation and use as intermediates in the synthesis of fragrance ingredients.Many fragrance ingredients that are used by perfumers in the creation of new and exciting fragrance accords are commodity ingredients, that is, they are non-proprietary and versions of the ingredients, which may differ in price and quality, and are available from many different suppliers. The uptake of a particular version of such ...

METHOD FOR PRODUCING 3,5-DIMETHYLDODECANOIC ACID; AND 4-CARBOXY-3,5-DIMETHYL-3,5-DODECADIENOIC ACID

Provided is a process for producing 3,5-dimethyldodecanoic acid, which is an active ingredient of the pheromone of California prionus, and 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid which is an intermediate useful for producing 3,5-dimethyldodecanoic acid. More specifically, provided is a method for producing 3,5-dimethyldodecanoic acid, comprising the steps of subjecting 3-methyl-2-pentene-1,5-diacid diester (1) and 2-nonanone (2) to a condensation reaction and subsequent hydrolysis into 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid (3); decarboxylating or decarboxylating and hydrolyzing the 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid (3) into 3,5-dimethyl-2,4-dodecadienoic acid (4); and hydrogenating the 3,5-dimethyl-2,4-dodecadienoic acid (4) into 3,5-dimethyldodecanoic acid (5), as shown in the following scheme: This application claims priority from Japanese Patent Application No. 2014-109166, filed May 27, 2014, the disclosure of which is incorporated by reference herein in its entirety.The present invention relates to a method for producing 3,5-dimethyldodecanoic acid, which is a sex pheromone of California prionus (), and relates to 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid, which is an intermediate of the dimethyldodecanoic acid.Sex pheromones of insects are usually bioactive substances released by individual females and having a function of attracting individual males. They show high attracting activity even in small amounts. Sex pheromones are widely used as a means for predicting the outbreak of insects or finding geological diffusion thereof (emergence into specific areas) or as a means for pest control. As a means for pest control, control methods called “mass trapping”, “lure & kill or attract & kill”, “lure & infect or attract & infect”, or “mating disruption” have been widely carried out in practice. To utilize a sex pheromone, economical production of a required amount of an active ingredient of the pheromone is necessary for basic research ...

Method for producing 3,5-dimethyldodecanoic acid

Provided is a process for producing 3,5-dimethyldodecanoic acid, which is an active ingredient of the pheromone of California prionus. More specifically provided is a method for producing 3,5-dimethyldodecanoic acid (5) comprising the steps of converting 2-methylnonyl halide (1) to a 2-methylnonyl metal reagent (2), and reacting the 2-methylnonyl metal reagent (2) with 2-ethylidene malonic acid ester (3) to form 2-(1,3-dimethyldecyl)malonic acid ester (4) as a result of 1,4-addition of the 2-methylnonyl metal reagent (2) to the 2-ethylidene malonic acid ester (3), as shown in the following scheme:

Recombinant host cells for the production of malonate

Systems and methods for the production of malonate in recombinant host cells.

A NOVEL PROCESS FOR THE SYNTHESIS OF 1-ARYL-1-TRIFLUOROMETHYLCYCLOPROPANES

The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A) 2. The process according to claim 1 , wherein Ris H.3. The process according to claim 1 , wherein Ris Br.4. The process according to claim 1 , wherein dicloromethane is used as solvent.5. The process according to claim 1 , wherein SFis added in an amount of 2 to 10 equivalents.6. The process according to claim 1 , wherein Ris H and the amount of HF is from 0.4 to 2.5 equivalents.7. The process according to claim 1 , wherein Ris Br and the amount of HF is from 1.5 to 2.5 equivalents.9. The process according to claim 8 , wherein Ris methyl.10. The process according to claim 8 , further comprising KPO claim 8 , Pd(OAc)and 2-biphenyl)-di-tert-butylphosphine.13. The process according to claim 12 , wherein dichloromethane is used as a solvent.14. The process according to or claim 12 , wherein SFis added in an amount of 2.7 to 10 equivalents.15. The process according to claim 12 , wherein Ris H claim 12 , and the amount of HF is from 0.4 to 2.5 equivalents.16. The process according to claim 12 , wherein Ris Br claim 12 , and the amount of HF is from 1.5 to 2.5 equivalents.18. Use of the compound of formula (Va) according to claim 12 , or a salt thereof claim 12 , in a process for manufacturing the compound of formula (I) as defined in claim 12 , or a salt thereof. The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A)which are described in WO 2015/186056.The target molecule of the present invention is the phenylacetic acid of Formula (I)It is produced in WO 2015/186056 from the compound of formula (II) wherein Ris Br, by a Negishi coupling with the Rieke reagent (2-(tert-butoxy)-2-oxoethyl)zinc(II) ...

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

A process for preparing industrially and efficiently glutamic acid compounds (such as monatin) useful as sweeteners or intermediates for the production of drugs or the like; a process for preparation of intermediates used therein; novel intermediates included among them; a process for preparation of optically active monatin; a process for preparation of intermediates used therein; and novel intermediates included among them. Specifically, a process for the preparation of glutamic acid compounds (or salts thereof) including monatin, which comprises preparing a ketoglutaric acid compound serving as a precursor of the objective glutamic acid compound by condensing a specific pyruvic acid compound with oxalacetic acid or pyruvic acid through cross-aldol reaction and, if necessary, subjecting the obtained condensate to decarboxylation, and replacing the carbonyl group of the ketoglutaric acid compound by an amino group.

Methods for the synthesis of olefins and derivatives

The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.

Metho dof obtaining cyclopropyl acetylene

베타-카로틴의 효율적인 제조방법

본 발명은 설폰 화학을 이용하여 카로틴 화합물의 합성에 유용하게 이용되는 신규의 중간체 화합물, 그 제조방법, 및 상기 중간체 화합물을 이용한 베타-카로틴의 효율적인 제조방법을 제공한다. 베타-카로틴의 제조방법은 탄소 10개로 이루어진 상기 중간체 화합물의 양끝에 있는 두 알데하이드 작용기에 각각 C 15 알릴릭 설폰 화합물을 반응시켜 탄소 40개로 이루어진 알코올 화합물을 얻고, 상기 C 40 화합물의 두 알코올기를 할로겐 또는 에테르로 변형시킨 다음, 더블 엘리미네이션(double elimination)의 방법으로 설폰기와 할로겐(또는 에테르)기를 모두 제거하며 이중결합을 형성하는 방법으로 컨쥬게이트 폴리엔 사슬 구조를 형성한 데 그 특징이 있다. 베타-카로틴, 설폰 화합물, 알데하이드, 폴리엔 체인, 더블 엘리미네이션

Производные винилкарбоновой кислоты, способ их получения и применение

Соединения формулы I, приведенной в описании, в свободной форме или в форме солей могут быть использованы в качестве пестицидов и получены способом, известным per se.

A kind of 2-(2-allyl group) preparation method of amylene-4-acid methyl esters

本发明涉及一种有机中间体2-（2-烯丙基）戊烯-4-酸甲酯的制备方法，制备方法如下：步骤1）丙二酸环(亚)异丙酯在氢氧化钾碱性条件下由PEG-400催化和3-溴丙烯反应生成化合物1；步骤2）化合物1在氢氧化钠的碱性条件下水解生成β-二酸化合物2；步骤3）β-二酸化合物2受热脱羧基生成单羧基的化合物3；步骤4）单羧基的化合物3经过甲酯化反应得到甲酯化合物4；步骤5）甲酯化合物4在LDA碱性条件下再次和3-溴丙烯反应生成目标化合物5。制备方法中所采用的原料为丙二酸环(亚)异丙酯和3-溴丙烯，成本低廉，合成过程步骤少，操作简单，提取纯化方便，收率可以达到80%以上。

"method for producing a compound, an alkyl ester and polymethyl methacrylate, for converting citramic acid to methacrylic acid, and for preparing polymers or copolymers, compound, polymethyl methacrylate".

"método para produzir um composto, um alquil éster e polimetilmetacrilato, para converter ácido citramálico a ácido metacrílico, e para preparar polímeros ou copolímeros, composto, polimetilmetacrilato". um método para produzir um composto da fórmula (i): em que r=h ou ch³ o método compreendendo expor uma fonte de um composto da fórmula (ii) às condições de reação de temperatura e pressão: fórmula (ii) em que r é definido como acima em que, quando r=ch3, a fonte de um composto da fórmula (ii) é exposta às condições de reação de temperatura e pressão enquanto estão em uma fase líquida. "method for producing a compound, an alkyl ester and polymethyl methacrylate, for converting citramic acid to methacrylic acid, and for preparing polymers or copolymers, compound, polymethyl methacrylate". a method for producing a compound of formula (i): wherein r = h or ch³ the method comprising exposing a source of a compound of formula (ii) to temperature and pressure reaction conditions: formula (ii) wherein r is defined as above wherein when r = ch3 the source of a compound of formula (ii) is exposed to temperature and pressure reaction conditions while in a liquid phase.

Preparation method of cyclobutane-1, 2-dicarboxylic anhydride and intermediate thereof

本发明涉及一种环丁烷‑1,2‑二甲酸酐(式I化合物)及其中间体的制备方法，具体的，以2,4‑二溴丁酸甲酯(式II化合物)为原料，与氰乙酸酯(式III化合物)在碱性条件下，关环生成式IV化合物；式IV化合物在酸或碱作用下水解脱羧生成环丁烷‑1,2‑二甲酸(式V化合物)；式V化合物在脱水试剂作用下关环生成环丁烷‑1,2‑二甲酸酐(式I化合物)。该方法操作简捷安全，收率良好，有很好的经济效应，适合工业化生产。

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

본 발명은 감미료 또는 의약품 등의 제조 중간체로서 유용한, 모나틴으로 대표되는 글루탐산 화합물을 공업적으로 효율적으로 제조하는 방법, 이를 위해 사용하는 제조 중간체의 제조방법이나 이들 중에 포함되는 신규 중간체 및 광학 활성 모나틴의 제조방법, 이를 위해 사용하는 제조 중간체의 제조방법 및 이들 중에 포함되는 신규 중간체 등의 제공에 관한 것이다. The present invention provides a method for industrially and efficiently preparing a glutamic acid compound represented by monatin, which is useful as a manufacturing intermediate for sweeteners or pharmaceuticals, a method for producing a manufacturing intermediate used for this purpose, or novel intermediates and optically active mons contained therein. The present invention relates to a method for preparing a tin, a method for preparing a manufacturing intermediate used for this purpose, and a novel intermediate contained in the same. 특정 피루브산 화합물과 옥살로아세트산 또는 피루브산을 교차 알돌 반응에 의해 축합시키고, 필요에 따라, 탈탄산 반응을 실시하는 것으로 목적하는 글루탐산 화합물의 전구체인 케토글루타르산 화합물을 제조하며, 또한 수득되는 케토글루타르산 화합물의 카보닐기를 아미노기로 변환시킴으로써 모나틴으로 대표되는 글루탐산 화합물(이들의 염 형태 포함)을 제조하는 방법을 제공한다. Condensation of a specific pyruvic acid compound with oxaloacetic acid or pyruvic acid by cross-aldol reaction, and if necessary, decarboxylation, to prepare a ketoglutaric acid compound, which is a precursor of a desired glutamic acid compound, and also a ketogluo obtained Provided are methods for preparing glutamic acid compounds, including their salt forms, represented by monatin, by converting the carbonyl group of the tartaric compound to an amino group. 글루탐산 화합물, 모나틴, 피루브산 화합물, 교차 알돌 반응, 탈탄산 반응, 중간체, 옥살로아세트산 Glutamic acid compound, monatin, pyruvic acid compound, cross-aldol reaction, decarbonation reaction, intermediate, oxaloacetic acid

Methods for the synthesis of olefins and derivatives

The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.

Methods for the synthesis of acrylic acid and derivatives from fumaric acid

The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.

Method of producing phenyllpyrimidine

Synthetic method of sitagliptin intermediate 2,4, 5-trifluoro phenylacetic acid

本发明提供了一种西格列汀中间体2,4,5‑三氟苯乙酸的合成方法，所述方法包括取代反应、水解反应和脱羧反应步骤，A、由化合物4经取代反应，或者先经取代反应后经水解反应制备得到式5化合物；B、由式5化合物经水解反应，制备得到式6化合物；C、由式6化合物在催化剂催化下，经脱羧反应制备得到2,4,5‑三氟苯乙酸，所述催化剂为金属氧化物。本发明的合成工艺低成本，高收率的制备得到2,4,5‑三氟苯乙酸化合物，工业化放大生产适用性强。

Process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes

The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A) which are described in WO 2015/186056.

Process for the preparation of diesters of glutaconic acid

本发明涉及精细化工领域，具体涉及一种戊烯二酸二酯的制备方法。戊烯二酸二酯的制备方法，以丙二酸二酯和卤代甲烷为原料，在碱作用条件下进行取代反应，再经脱羧、酯化反应制备戊烯二酸二酯，结构式见化合物(Ⅸ)。该方法反应条件温和、易操作，工艺安全的戊烯二酸二酯的制备方法。该制备方法反应条件温和、易操作，工艺安全。

Process for the preparation of optically active 3-alkylcarboxylic acids

Gegenstand der Erfindung ist ein enantioselektives Verfahren zur Herstellung optisch aktiver 3-Alkylcarbonsäuren, enthaltend die folgenden Schritte: DOLLAR A A) Überführen eines optisch aktiven sekundären Alkohols in eine optisch aktive, aktivierte Verbindung durch Einführung einer Abgangsgruppe, DOLLAR A B) Umsetzung mit einem Malonsäurederivat - unter stereoselektiver Inversion - zu einer optisch aktiven, alkylierten Malonsäureverbindung, DOLLAR A C) gegebenenfalls Verseifung zu der korrespondierenden Säure und DOLLAR A D) abschließende Decarboxylierung der Säure zur optisch aktiven 3-Alkylcarbonsäure als Produkt. The invention relates to an enantioselective process for preparing optically active 3-alkylcarboxylic acids, comprising the following steps: DOLLAR AA) conversion of an optically active secondary alcohol into an optically active, activated compound by introduction of a leaving group, DOLLAR AB) reaction with a Malonsäurederivat - under stereoselective inversion - to an optically active, alkylated malonic acid compound, DOLLAR AC) optionally saponified to the corresponding acid and DOLLAR AD) final decarboxylation of the acid to optically active 3-alkylcarboxylic acid as a product.

The improved method for preparing tetrafluorobenzoic aid

一种改进的制备2，3，4，5-四氟苯甲酸的方法。其中包括在碱性催化剂存在下，四氟邻苯二甲酸的脱羧作用。也描述了一种改进了的制备四氟邻苯二甲酸的方法，以及结合应用此两种改进了的方法，依次地用一系列方法来制备四氟苯甲酸。

Preparation method of 1,3-cyclohexanedicarboxylic acid

본 발명은, 우수한 활성을 나타내며, 고온 및 강산의 반응 조건에서 내구성이 향상된 촉매를 사용하여 반응의 효율 및 경제성을 높일 수 있고, 반응물이 대부분 반응에 참여하여 우수한 전환율을 구현할 수 있으며, 보다 짧은 시간 안에 부산물을 최소화하면서도 고순도의 생성물을 얻을 수 있는 1,3-사이클로헥산디카르복시산 제조 방법에 관한 것으로, 상기 1,3-사이클로헥산디카르복시산의 제조 방법은 실리카 담체에 고정되고, 팔라듐(Pd) 화합물 및 구리(Cu) 화합물이 1:0.1 내지 0.5의 중량비로 포함된 금속 촉매의 존재 하에, 이소프탈산을 환원시키는 단계를 포함할 수 있다. The present invention can improve the efficiency and economical efficiency of a reaction by using a catalyst having excellent activity and improved durability under high temperature and strong acid reaction conditions, Cyclohexanedicarboxylic acid in which the product of 1,3-cyclohexanedicarboxylic acid can be obtained while minimizing the byproducts in the process for producing 1,3-cyclohexanedicarboxylic acid, And a copper (Cu) compound in a weight ratio of 1: 0.1 to 0.5, in the presence of a metal catalyst.

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

A process for preparing industrially and efficiently glutamic acid compounds (such as monatin) useful as sweeteners or intermediates for the production of drugs or the like; a process for preparation of intermediates used therein; novel intermediates included among them; a process for preparation of optically active monatin; a process for preparation of intermediates used therein; and novel intermediates included among them. Specifically, a process for the preparation of glutamic acid compounds (or salts thereof) including monatin, which comprises preparing a ketoglutaric acid compound serving as a precursor of the objective glutamic acid compound by condensing a specific pyruvic acid compound with oxalacetic acid or pyruvic acid through cross-aldol reaction and, if necessary, subjecting the obtained condensate to decarboxylation, and replacing the carbonyl group of the ketoglutaric acid compound by an amino group.

Glutamic acid compounds, process for producing the production intermediates thereof, and novel intermediates therefor

Procedures for the preparation of glutamic acid compounds and intermediates thereof and new intermediates used in the processes

Un proceso para producir un compuesto de ácido glutámico representado por la siguiente fórmula (7) .o una sal del mismo, incluyendo una etapa para tratar un compuesto de ácido pirúvico representado por la siguiente fórmula (1) y ácido oxalacético representado por la siguiente fórmula (2) mediante una reacción aldólica cruzada y reacción de descarboxilación o para tratar el compuesto de ácido pirúvico (excepto ácido pirúvico) y un ácido pirúvico representado por la siguiente fórmula (2') mediante una reacción aldólica cruzada, para obtener un compuesto de ácido cetoglutárico representado por la siguiente fórmula (4) o una sal del mismo, y una etapa para convertir el grupo carbonilo del compuesto de ácido cetoglutárico o una sal del mismo en un grupo amino, en el que el compuesto de ácido pirúvico, ácido oxalacético y ácido pirúvico puede estar individualmente en formas de sal de los mismos: en las fórmulas anteriores, R1 representa un grupo seleccionado de grupos alquilo, grupos arilo, grupos aralquilo y grupos hidrocarburo que contienen anillos heterocíclicos; y R1 puede tener al menos un sustituyente seleccionado de átomos de halógeno, grupo hidroxilo, grupos alquilo con uno a tres átomos de carbono, grupos alcoxi con uno a tres átomos de carbono y grupo amino. A process for producing a glutamic acid compound represented by the following formula (7) or a salt thereof, including a step for treating a pyruvic acid compound represented by the following formula (1) and oxalacetic acid represented by the following formula (2) by a cross-aldol reaction and decarboxylation reaction or to treat the pyruvic acid compound (except pyruvic acid) and a pyruvic acid represented by the following formula (2 ') by a cross-aldol reaction, to obtain an acid compound ketoglutaric represented by the following formula (4) or a salt thereof, and a step to convert the carbonyl group of the ketoglutaric acid compound or a salt thereof into an amino group, wherein the pyruvic acid ...

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

Processes of producing glutamic acid compounds and production intermediates therefor and novel intermediate for the processes

A process for preparing industrially and efficiently glutamic acid compounds such as monatin useful as sweeteners or intermediates for the production of drugs or the like a process for preparation of intermediates used therein novel intermediates included among them a process for preparation of optically active monatin a process for preparation of intermediates used therein and novel intermediates included among them. Specifically, a process for the preparation of glutamic acid compounds or salts thereof including monatin, which comprises preparing a ketoglutaric acid compound serving as a precursor of the objective glutamic acid compound by condensing a specific pyruvic acid compound with oxalacetic acid or pyruvic acid through cross-aldol reaction and, if necessary, subjecting the obtained condensate to decarboxylation, and replacing the carbonyl group of the ketoglutaric acid compound by an amino group.

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes for the preparation of glutamic acid compounds intermediates and novel intermediates used in the processes

本发明涉及提供在工业上有效制造对作为甜味料或医药品等的制备中间体有用的、以莫纳汀为代表的谷氨酸化合物的制造方法、为此所用的制备中间体的制造方法和其中所含有的新型中间体以及光学活性莫纳汀的制造方法、为此所用的制备中间体的制造方法和其中所含有的新型中间体等。提供了以通过由特定的丙酮酸化合物与草酰乙酸或丙酮酸的交叉醛醇反应而缩合、根据需要而进行脱羧反应，制造作为目标谷氨酸化合物的前体的氧代戊二酸化合物，进而把所得到的氧代戊二酸化合物的羰基转换为氨基，以制造由莫纳汀为代表的谷氨酸化合物(包括它们的盐形态)的制造方法。

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

本发明涉及提供在工业上有效制造对作为甜味料或医药品等的制备中间体有用的、以莫纳汀为代表的谷氨酸化合物的制造方法、为此所用的制备中间体的制造方法和其中所含有的新型中间体以及光学活性莫纳汀的制造方法、为此所用的制备中间体的制造方法和其中所含有的新型中间体等。提供了以通过由特定的丙酮酸化合物与草酰乙酸或丙酮酸的交叉醛醇反应而缩合、根据需要而进行脱羧反应，制造作为目标谷氨酸化合物的前体的氧代戊二酸化合物，进而把所得到的氧代戊二酸化合物的羰基转换为氨基，以制造由莫纳汀为代表的谷氨酸化合物(包括它们的盐形态)的制造方法。

Glutamic acid compounds, process for producing the production intermediates thereof, and novel intermediates therefor

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

A process for preparing industrially and efficiently glutamic acid compounds (such as monatin) useful as sweeteners or intermediates for the production of drugs or the like; a process for preparation of intermediates used therein; novel intermediates included among them; a process for preparation of optically active monatin; a process for preparation of intermediates used therein; and novel intermediates included among them. Specifically, a process for the preparation of glutamic acid compounds (or salts thereof) including monatin, which comprises preparing a ketoglutaric acid compound serving as a precursor of the objective glutamic acid compound by condensing a specific pyruvic acid compound with oxalacetic acid or pyruvic acid through cross-aldol reaction and, if necessary, subjecting the obtained condensate to decarboxylation, and replacing the carbonyl group of the ketoglutaric acid compound by an amino group.

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes of producing glutamic acid compounds and production intermediates therefor and novel intermediate for the processes

A process for preparing industrially and efficiently glutamic acid compounds (such as monatin) useful as sweeteners or intermediates for the production of drugs or the like; a process for preparation of intermediates used therein; novel intermediates included among them; a process for preparation of optically active monatin; a process for preparation of intermediates used therein; and novel intermediates included among them. Specifically, a process for the preparation of glutamic acid compounds (or salts thereof) including monatin, which comprises preparing a ketoglutaric acid compound serving as a precursor of the objective glutamic acid compound by condensing a specific pyruvic acid compound with oxalacetic acid or pyruvic acid through cross-aldol reaction and, if necessary, subjecting the obtained condensate to decarboxylation, and replacing the carbonyl group of the ketoglutaric acid compound by an amino group.

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

本发明涉及提供在工业上有效制造对作为甜味料或医药品等的制备中间体有用的、以莫纳汀为代表的谷氨酸化合物的制造方法、为此所用的制备中间体的制造方法和其中所含有的新型中间体以及光学活性莫纳汀的制造方法、为此所用的制备中间体的制造方法和其中所含有的新型中间体等。提供了以通过由特定的丙酮酸化合物与草酰乙酸或丙酮酸的交叉醛醇反应而缩合、根据需要而进行脱羧反应，制造作为目标谷氨酸化合物的前体的氧代戊二酸化合物，进而把所得到的氧代戊二酸化合物的羰基转换为氨基，以制造由莫纳汀为代表的谷氨酸化合物(包括它们的盐形态)的制造方法。

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

本发明涉及提供在工业上有效制造对作为甜味料或医药品等的制备中间体有用的、以莫纳汀为代表的谷氨酸化合物的制造方法、为此所用的制备中间体的制造方法和其中所含有的新型中间体以及光学活性莫纳汀的制造方法、为此所用的制备中间体的制造方法和其中所含有的新型中间体等。提供了以通过由特定的丙酮酸化合物与草酰乙酸或丙酮酸的交叉醛醇反应而缩合、根据需要而进行脱羧反应，制造作为目标谷氨酸化合物的前体的氧代戊二酸化合物，进而把所得到的氧代戊二酸化合物的羰基转换为氨基，以制造由莫纳汀为代表的谷氨酸化合物(包括它们的盐形态)的制造方法。

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

A process for preparing industrially and efficiently glutamic acid compounds (such as monatin) useful as sweeteners or intermediates for the production of drugs or the like: a process for preparation of intermediates used therein: novel intermediates included among them: a process for preparation of optically active monatin: a process for preparation of intermediates used therein: and novel intermediates included among them. Specifically, a process for the preparation of glutamic acid compounds (or salts thereof) including monatin, which comprises preparing a ketoglutaric acid compound serving as a precursor of the objective glutamic acid compound by condensing a specific pyruvic acid compound with oxalacetic acid or pyruvic acid through cross-aldol reaction and, if necessary, subjecting the obtained condensate to decarboxylation, and replacing the carbonyl group of the ketoglutaric acid compound by an amino group.

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Glutamic acid compounds, process for producing the production intermediates thereof, and novel intermediates therefor

甘味料又は医薬品等の製造中間体として有用な、モナティンに代表されるグルタミン酸化合物を工業的に効率よく製造する方法、そのために使用する製造中間体の製造方法やそれらの中に含まれる新規中間体、並びに光学活性モナティンの製造方法、そのために使用する製造中間体の製造方法及びそれらの中に含まれる新規中間体等の提供に関する。特定のピルビン酸化合物と、オキサロ酢酸又はピルビン酸とを交叉アルドール反応により縮合し、必要により脱炭酸反応を行うことで目的とするグルタミン酸化合物の前駆体となるケトグルタル酸化合物を製造し、更に得られたケトグルタル酸化合物のカルボニル基をアミノ基に変換することにより、モナティンに代表されるグルタミン酸化合物（それらの塩の形態を含む）を製造する方法を提供する。 A method for industrially and efficiently producing a glutamic acid compound represented by monatin, which is useful as a production intermediate for sweeteners or pharmaceuticals, etc., a method for producing a production intermediate used therefor, and a novel intermediate contained therein The present invention also relates to a method for producing optically active monatin, a method for producing a production intermediate used therefor, and provision of a novel intermediate contained therein. A specific pyruvic acid compound and oxaloacetic acid or pyruvic acid are condensed by a cross-aldol reaction, and if necessary, a decarboxylation reaction is performed to produce a ketoglutarate compound that becomes a precursor of the target glutamic acid compound, and further obtained. The present invention also provides a method for producing a glutamic acid compound represented by monatin (including a salt form thereof) by converting a carbonyl group of the ketoglutaric acid compound into an amino group.

Process for the preparation of compounds containing peroxycarbonyl ester groups

Process for prepn. of cyclopropyl carboxylic acid esters and derivatives

本发明涉及某些环丙基羧酸酯和其它环丙基羧酸衍生物的新的制备方法；二甲基氧化锍亚甲基化合物和二甲基锍亚甲基化合物的新的制备方法；涉及某些环丙基羧酸酯在制备用来合成药学上的活性实体的中间体的方法中的应用；还涉及通过这些方法得到的某些中间体。

Preparation method of bromfenac sodium

本发明提供一种溴芬酸钠(Ⅰ)的制备方法，该方法利用对溴苯甲酸酯(Ⅱ)和2‑烷氧基羰基‑6‑烷氧基羰基甲基环己酮(Ⅲ)为原料，于碱作用下缩合，然后水解、脱羧得到2‑[3‑(4‑溴苯甲酰基)‑2‑氧代环己基]乙酸(IV)，此后和卤代试剂经取代反应得到2‑[1,3‑二卤代‑3‑(4‑溴苯甲酰基)‑2‑氧代环己基]乙酸(V)，然后和氨进行氨化反应，在碱作用下经消除反应得溴芬酸(Ⅵ)，最后经成盐得到溴芬酸钠(Ⅰ)。本发明方法原料价廉易得，工艺流程简便，反应条件温和、易于实现，成本低；废水产生量少，安全绿色环保；中间产物稳定，反应活性和选择性高，副反应少，所得溴芬酸钠产率和纯度高，适合工业化生产。

Process for the preparation of [bis (trifluoromethyl) phenyl] acetic acids and their alkyl esters and [bis (trifluoromethyl) phenyl] malonic acid dialkyl ester

Bis-(trifluormethyl)-phenylF-essigsäuren werden in vorteilhafter Weise erhalten, wenn man ein entsprechendes Brom- oder Iod-bis-(trifluormethyl)-benzol mit einem Malonsäure-di-C 1 -C 4 -alkylester in Gegenwart eines Deprotonierungsagenzes und eines Kupfersalzes umsetzt und das Reaktionsprodukt in basischem Medium verseift und decarboxyliert. Ein Gemisch aus Bis-(trifluormethyl)-phenylF-essigsäurealkylester und Bis-(trifluormethyl)-phenylF-malonsäurealkylester kann erhalten werden, wenn das vor der Verseifung und vollständigem Decarboxylierung vorliegende Reaktionsgemisch mit Wasser und Säure versetzt und erwärmt. Aus dem Gemisch kann man Bis-(trifluormethyl)-phenylF-essigsäurealkylester erhalten, indem man es bei vermindertem Druck destilliert und Bis-(trifluormethyl)-phenylF-malonsäuredialkylester, wenn man es mittels Säulenchromatographie, fraktionierte Destillation oder Dünnschichtdestillation aufarbeitet. DOLLAR A Bis-(trifluormethyl)-phenylF-malonsäureester sind neue Verbindungen.

A kind of natural products E-2,3 ', the synthetic method of 4,5 '-tetrahydroxystilbenes

本发明公开了一种天然产物E‑2,3’,4,5’‑四羟基二苯乙烯的合成方法，以1,3‑丙酮二羧酸二甲酯为起始原料，经缩合、芳构化反应得到3,5‑二羟基‑2,4‑二甲氧羰基苯乙酸甲酯，再经水解、脱羧得到3,5‑二羟基苯乙酸，3,5‑二羟基苯乙酸与2,4‑二羟基苯甲醛在碱存在下发生缩合反应得到3‑(3,5‑二羟基苯基)‑7‑羟基香豆素，再在碱性条件下发生开环脱羧反应，得到天然产物E‑2,3’,4,5’‑四羟基二苯乙烯。本方法原料易得，反应路线简捷，操作方便，产率较高。

Alternative routes to adipates and adipic acid by combined fermentation and catalytic methods

resumo patente de invenção: "vias alternativas para adipatos e ácido adípico por métodos de fermentação e catalíticos combinados". processos para produzir adipato ou ácido adípico usando vias biológicas e catalisadores químicos são divulgados. ácido homocítrico pode ser um substrato em vias de reação levando a ácido adípico ou um sal deste. Patent Summary: "Alternative pathways for adipates and adipic acid by fermentation and combined catalytic methods". Methods for producing adipate or adipic acid using biological pathways and chemical catalysts are disclosed. Homocitric acid may be a reaction substrate leading to adipic acid or a salt thereof.

A process for the production of methacrylic acid and its derivatives and polymers produced therefrom

A process for the production of methacrylic acid by the base catalysed decarboxylation of at least one dicarboxylic acid selected from itaconic, citraconic or mesaconic acid or mixtures thereof is described. The decarboxylation is carried out at a temperature in the range from 100 to 199°C. A method of preparing polymers or copolymers of methacrylic acid or methacrylic acid esters is also described.

Method of making 2,4,5-trihalobenzoic acid

Abstract of the Disclosure Disclosed is a method of making 2,4,5-trihalobenzoic acid by heating to a temperature of about 130 to about 190°C a composition that comprises water, a mineral acid, and a compound having the general formula

2-Substd. methyl-4-aryl-piperidines - analgesics prepd. by cyclisation of 3-allyl-3-phenyl propyl-N-chloro-amine

PHARMACEUTICAL COMPOSITION COMPRISING DOCOSANOL AS ACTIVE INGREDIENT

Patent FR3124M

PHARMACEUTICAL COMPOSITION CONTAINING POLYPRENYL COMPOUND

L'INVENTION A POUR OBJET UNE COMPOSITION PHARMACEUTIQUE COMPRENANT A TITRE DE PRINCIPE ACTIF UN COMPOSE POLYPRENYLIQUE CHOISI PARMI LES COMPOSES POLYPRENYLIQUES REPONDANT AUX FORMULES SUIVANTES: (CF DESSIN DANS BOPI) DANS LAQUELLE N EST UN NOMBRE ENTIER DE 5 A 7 ET R REPRESENTE UN RADICAL ALKYLE INFERIEUR OU ACYLE ALIPHATIQUE OU AROMATIQUE, (CF DESSIN DANS BOPI) DANS LAQUELLE A ET B REPRESENTENT CHACUN UN ATOME D'HYDROGENE OU A ET B SONT COMBINES ENSEMBLE POUR FORMER UNE LIAISON ET N EST UN NOMBRE ENTIER DE 1 A 10. THE SUBJECT OF THE INVENTION IS A PHARMACEUTICAL COMPOSITION COMPRISING AS ACTIVE PRINCIPLE A POLYPRENYL COMPOUND CHOSEN FROM THE POLYPRENYL COMPOUNDS RESPONDING TO THE FOLLOWING FORMULAS: (CF DRAWING IN BOPI) IN WHICH N IS A WHOLE NUMBER OF 5 TO 7 AND A RADICAL REPRENT LOWER ALKYL OR ALIPHATIC OR AROMATIC ACYL, (CF DRAWING IN BOPI) IN WHICH A AND B EACH REPRESENT A HYDROGEN ATOM OR A AND B COMBINE TOGETHER TO FORM A BOND AND N IS A WHOLE NUMBER FROM 1 TO 10.

Decarboxylation of halogenated aromatic carboxylic acids

ALCOHOL B DERIVATIVES, G-DIHYDROPOLYPRENYLIC AND PHARMACEUTICAL COMPOSITION CONTAINING A POLYPRENYLIC COMPOUND

Acrylic acid manufacturing process

B, G-DIHYDROPOLYPRENYL ALCOHOL DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING POLYPRENYL COMPOUND

DERIVES D'ALCOOL B,G-DIHYDROPOLYPRENYLIQUE ET COMPOSITION PHARMACEUTIQUE CONTENANT UN COMPOSE POLYPRENYLIQUE; LES DERIVES D'ALCOOL B,G-DIHYDROPOLYPRENYLIQUE REPONDANT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE N EST UN NOMBRE ENTIER DE 5 A 7 ET R REPRESENTE UN ATOME D'HYDROGENE OU UN RADICAL ALKYLE INFERIEUR OU ACYLE ALIPHATIQUE OU AROMATIQUE SONT DE NOUVEAUX COMPOSES UTILES COMME AGENTS PROPHYLACTIQUES ET THERAPEUTIQUES CONTRE LES MALADIES DE L'HOMME ET DES ANIMAUX DUES A UN DEFICIT IMMUNITAIRE ET COMME AGENTS PHYLACTIQUES CONTRE LES MALADIES INFECTIEUSES DE L'HOMME ET DES ANIMAUX; D'AUTRES COMPOSES POLYPRENYLIQUES D'UTILITE SEMBLABLE SONT EGALEMENT DECRITS. ALCOHOL B, G-DIHYDROPOLYPRENYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING A POLYPRENYL COMPOUND; ALCOHOL B, G-DIHYDROPOLYPRENYL DERIVATIVES RESPONDING TO THE FORMULA: (CF DRAWING IN BOPI) IN WHICH N IS AN ENTIRE NUMBER FROM 5 TO 7 AND R REPRESENTS A HYDROGEN ATOM OR A LOWER OR ALIPHATIC ACYL OR RADICAL ALKYL ARE NEW COMPOUNDS USEFUL AS PROPHYLACTIC AND THERAPEUTIC AGENTS AGAINST DISEASES IN HUMANS AND ANIMALS DUE TO AN IMMUNE DEFICIT AND AS PHYLACTIC AGENTS AGAINST INFECTIOUS DISEASES IN MAN AND ANIMALS; OTHER POLYPRENYLIC COMPOUNDS OF SIMILAR USE ARE ALSO DESCRIBED.

PHARMACEUTICAL COMPOSITION CONTAINING A POLYPRENYL DERIVATIVE

Polyfluorocarboxylic acids and salts

Polyfluorocarboxylic acids of formula Rf(CH2)n-C(R)(R')(COOM) (I) and salts of these. The polyfluorocarboxylic acids and salts have the formula (I) in which RF = a perfluorinated group, linear or branched, with 4-18 C: n = 2, 3 or 11; M = H, Na or K; R = 1-18 C alkyl, aryl or aralkyl, any of which may be substituted, allyl, methallyl or propargyl, a polyoxyethylated group, a 2-oxoalkyl group R"COCH2- (R" = biphenyl substituted with a 1-10 C alkyl, an aralkyl group or a nitrile function), COOH, a perfluorinated group RF(CH2)2NHC(O)CH2- or a group RF(CH2)nCR'(COOM)-(CH2)m-2- (m-2 = 4,5,6,8,10,11,12 or 14 and n = 2, 3 or 11); R' = H or COOM (M = as above) . The optional substituents on the alkyl, aryl, or aralkyl groups are e.g. OH, SH, oxo or carboxylic groups. An independent claim refers to a method of production of the compounds (I) starting with saponification of the corresponding ester compounds. A further independent claim refers to the use of the compounds (I) as intermediates in the synthesis of surfactants and in the preparation of vesicular systems.

New process for preparing chrysanthemic acid

New process for preparing pyrocine

NEW SUBSTITUTED 2-INDANOLS-4 AND PREPARATION OF CORRESPONDING ESTERS

Pharmaceutical composition comprising 3,7,11,15-tetramethyl-1-hexadecen-3-ol as active principle

L'INVENTION A POUR OBJET UNE COMPOSITION PHARMACEUTIQUE COMPRENANT A TITRE DE PRINCIPE ACTIF LE 3,7,11,15-TETRAMETHYLHEXADECA-1-ENE-3-OL.

Patent FR2443245B1

PHARMACEUTICAL COMPOSITION COMPRISING AS ACTIVE INGREDIENT 3,7,11,15 - TETRAMETHYL -1,6,10,14-HEXADECATETRAENE-3-OL

PROCESS FOR PREPARING STEREOSPECIFIC ISOMERS OF FARNESYLACETIC ACID, ITS ESTERS AND THEIR DERIVATIVES

Patent FR2524463B1