09-05-2013 дата публикации
Номер: US20130116232A1
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': '1', 'sub': 1', '4, 'Ris C-Calkyl;'}{'sup': 2a', '2b, 'Rand Rare taken together with the N atom to which they are attached to form a substituted or unsubstituted monocyclic heterocycloalkyl, a substituted or unsubstituted bicyclic heterocycloalkyl, a substituted or unsubstituted monocyclic heteroaryl, or a substituted or unsubstituted bicyclic heteroaryl;'}{'sup': '3', 'sub': 1', '4', '1', '4, 'Ris C-Calkyl or C-Cfluoroalkyl;'}{'sup': 4', '9', '9', '10', '10, 'sub': 2', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'each Ris independently selected from H, halogen, —CN, —OH, —OR, —SR, —S(═O)R, —S(═O)R, C-Calkyl, C-Cfluoroalkyl, C-Cfluoroalkoxy, C-Calkoxy, and C-Cheteroalkyl;'}{'sup': 5', '9, 'sub': 1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'each Ris independently selected from H, halogen, —CN, —OH, —OR, C-Calkyl, C-Cfluoroalkyl, C-Cfluoroalkoxy, C-Calkoxy, and C-Cheteroalkyl;'}{'sup': '6', 'sub': 1', '6', '1', '6', 'r', '6', '1', '6, 'each Ris independently selected from H, halogen, —CN, —OH, C-Calkyl, C-Cfluoroalkyl, CCfluoroalkoxy, and C-Calkoxy;'}{'sup': '7', 'sub': '3', 'Ris H or —CH;'}Y is —O— or —S—.46-. (canceled)7. The compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein:{'sup': '1', 'sub': '3', 'Ris —CH;'}{'sup': '3', 'sub': 3', '3, 'Ris —CHor —CF;'}{'sup': 2a', '2b, 'Rand Rare taken together with the N atom to which they are attached to form a substituted or unsubstituted pyrrolidinyl;'}X is —O—;Y is —O—.8. (canceled)11. (canceled)13. The compound ...
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