ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ

Описываются новые трициклические соединения общей формулы I, где А и В независимо означают СН или азот; D означает С-W или азот; W означает водород, галоген, С1-6 -алкил или группу СН2NR6R7, где R6 и R7 независимо означают С1-6-алкил с прямой цепью; Е и G означают одновременно СН или азот; R1 означает алканоил, содержащий 2-7 атомов углерода, группу, выбранную из CN, CONH2, или остаток, выбранный из групп (а), (b), (с), (d), (е), (f), (g), (h), (i), (j), (k) и (m); где R2 - водород или С1-6-алкил с прямой цепью, С3-7-циклоалкил или CF3; R3 и R5 - независимо водород или С1-6-алкил; R4 - водород, С1-6-алкил с прямой цепью, алкоксиалкил, содержащий 2-7 атомов углерода, циклоалканоил, содержащий 3-7 атомов углерода, бензоил, замещенный галогеном, С1-6 -алкилом или фенилом, который, в свою очередь, является незамещенным или замещенным CF3, или тиофеналканоил; Х - водород; Y - водород, С1-6-алкил с прямой цепью, С1-6 -алкокси, гидрокси, галоген или CF3, или их фармацевтически приемлемые соли, ...

СПОСОБ ПОЛУЧЕНИЯ N-(1,5,3-ДИТИАЗЕПАН-3-ИЛ)АМИДОВ

Способ получения N-(1,5,3-дитиазепан-3-ил)амидов общей формулы (1):где R=p-CHN (а), (CH)CO (b), o-CHOCH(с)отличающийся тем, что N,N,N,N-тетраметил-2,5-дитиагексан-1,6-диамин подвергается взаимодействию с гидразидом общей формулы RC(O)NHNH[R = указанные выше] в присутствии катализатора кристаллогидрата нитрата саммария Sm(NO)·6НO при мольном соотношении N,N,N,N-тетраметил-2,5-дитиагексан-1,6-диамин: RC(O)NHNH: Sm(NO)·6НO=10:10:(0.3-0.7) при температуре 65-75°С и атмосферном давлении в смеси растворителей этиловый спирт - хлороформ в течение 20-28 ч.

ИМИДАЗОЛИЛЬНЫЕ ПРОИЗВОДНЫЕ КАК ИНГИБИТОРЫ КОРТИКОТРОПИН-РИЛИЗИНГ ФАКТОРА

... 1. Соединение Формулы (I) или его фармацевтически приемлемая соль или сольват, где R1 обозначает Н, C1-6 алкил, C1-6 галогеналкил, C1-6алкокси, C1-6тиоалкил, циано, галоген, С3-7циклоалкил, -C1-6алкилен - С3-7циклоалкил, С2-6 алкенил или С3-6 алкинил; R2 обозначает C(D)NR3R4, D’-D’’(R3)R4 или CH2NR3R4 D’ обозначает СН2 или связь; D’’ обозначает С, С-ОН или СН, где указанный С присоединен к R3 ординарной или двойной связью; указанный С присоединен к R4 ординарной или двойной связью; при условии, что С не присоединен двойными связями ни к R3, ни к R4; указанный С присоединен к R3 и к R4 ординарными связями; указанный С группы С-ОН присоединен к R3 и R4 ординарными связями; D обозначает О или S; R3 и R4, каждый, независимо, выбирают из группы, состоящей из Н, C1-6алкила, C1-6галогеналкила, C1-6 гидроксиалкила, -С1-4алкилен-О- С1-4алкила, -С1-3алкилен-С1-6тиоалкила, -С2-6алкилиден-(С1-4алкокси)2, С3-7 циклоалкил, -С1-6алкилен-С3-7циклоалкил, С2-6алкенил, С3-6алкинил, -С1-6алкилен-CN, -C1-6алкиленгетероцикло ...

Способ получения трициановинильных производных дифенилформазанов, или фенилгидразонов, или N-фенилозотриазолов углеводов

Novel ortho- or para- substituted azo compounds especially for use as dyes in optical uses are prepared by direct nucleophilic coupling synthesis from novel perfluoroalkanesulfonyl triazoles

Preparation of azo compounds involves coupling a perfluoroalkanesulfonyl triazole with a nucleophilic coupling component. Preparation of azo compounds involves coupling a perfluoroalkanesulfonyl triazole of formulae (I) or (II) with a nucleophilic coupling component. R Fperfluoroalkyl (-CF 3, -C 2F 5, -C 3F 7, C 4F 9 etc); R 1> and R 2>H, optionally mono- or poly-substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, hetaryl, acyl, halogen, haloalkyl, sulfo, sulfato, sulfonyl, sulfamoyl, alkylsulfonyl, phosphato, hydroxy, cyano, nitro, amino, alkoxy, alkenyloxy, alkinyloxy, alkylthio, carboxy, aminocarbonyl, alkylcarbonyl, alkoxycarbonyl, phenyl, naphthyl or a heterosubstituent; and ring III : optionally mono- or poly-substituted cycloalkane, cycloalkene, heterocycle, benzene or heteroarene. Independent claims are also included for (1) the azo compounds thus obtained; (2) the perfluoroalkanesulfonyl triazole starting materials of formulae (I) and (II); and (3 ...

1,2,4-TRIAZOLO[4,3-B]PYRIDO[3,2-D]PYRIDAZINDERIVATE UND DIESE ENTHALTENDE PHARMACEUTISCHE ZUBEREITUNGEN

Chloracetamide, Verfahren zu ihrer Herstellung und diese enthaltende herbizide Mittel

HEMMER DER MENSCHLICHEN PHOSPHATIDYL-INOSITOL-3-KINASE DELTA

Piperazine derivatives for the treatment of HIV infections.

Tricyclic 5,6-dihydro-9H-pyrazolo[3,4c]-1,2,4-triazolo[4,3-A]pyridines.

A compound of the formula wherein r1, r2, r3, r9 and r10 are as defined above. The compound of formula i and the pharmaceutically acceptable salts thereof are useful in inhibiting phosphodiesterase (pde)type iv and the production of tumor necrosis factor (tnf)and in the treatment of asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases charactrized by phosphodiesterase (pde)type iv activity as well as aids, sepsis, septic shock and other diseases, such as cachexia, involving the production of tnf.

Tricyclic 5,6-dihydro-9H-pyrazolo[3,4c]-1,2,4-triazolo[4,3-a]pyridines

Novel imidazole compounds as transforming growth factor (TGD) inhibitors.

Triazole compounds useful in therapy.

Herbicidal compositions containing triazolinones

Novel imidazole compounds as transforming growth factor (TGF) inhibitors.

Tricyclic 5,6-dihydro-9h-pyrazolo Ä3,4-cÜ-1,2,4-triazolo Ä4,3-alphaÜpyridines

Triazole compounds useful in therapy.

Novel imidazole compounds as transforming growth factor (TGD) inhibitors.

Derivatives of A 1-phenyltriazole as antiparasiticagents

Triazole compounds useful in therapy.

Novel imidazole compounds as transforming growth factor (TGD) inhibitors.

Tricyclic 5,6-dihydro-9H-pyrazolo[3,4c]-1,2,4-triazolo[4,3-a]pyridines

Triazole compounds useful in therapy.

USE OF ANASTROZOL CANCER OF THE BREAST EARLY FOR THE TREATMENT OF POSTMENOPAUSALEN MRS WITH

HERBICIDE

VERFAHREN ZUR HERSTELLUNG EINES BENZOTRIAZOLS ZUR VERMEIDUNG DER AN KUPFER BEWIRKTEN KORROSION DURCH ORGANISCHE GEMISCHE

PROCEDURE FOR THE PRODUCTION OF NEW CONNECTIONS

FUNGICIDES MIXTURES FOR AGRICULTURAL PURPOSES

PROCEDURE FOR THE PRODUCTION OF NEW AMIDE IN METAL COMPLEXES

PROCEDURE FOR the PRODUCTION of a NEW ONE 1,2,4-TRIAZOLNUKLEOSIDS

PROCEDURE FOR the PRODUCTION OF NEW ONE 1,2,4-TRIAZOLDERIVATEN

PROCEDURE FOR THE PRODUCTION OF TRIAZOLYL ISOPROPANOLEN

PROCEDURE FOR the PRODUCTION OF NEW ONE 1,2,4-TRIAZOLVERBINDUNGEN

MEANS FOR THE FIGHT AGAINST UNWANTED PLANTS

PROCEDURE FOR the PRODUCTION OF NEW ONE 2 (4H-1,2,4 - TRIAZOLYL) - BENZOPHENONEN AND THEIR SALTS

PROCEDURE FOR THE PRODUCTION OF NEW HETERO-CYCLIC CONNECTIONS

PROCEDURE FOR the PRODUCTION OF NEW ONE 1,2,4TRIAZOLDERIVATEN

THERAPEUTIC APPLICATION A ANTIINVASIVEN OF A CONNECTION

TREATMENT OF SLEEP DISTURBANCES USING CERTAIN ANTIDEPRESSIVES, E.G. NEFAZODON

TRIAZOLYLALKYL MORE THIOETHER, PROCEDURES FOR YOUR PRODUCTION AS WELL AS YOUR USE THAN PLANT GROWTH MODULATORS AND FUNGICIDES.

TRIAZOLYLPROPENOL DERIVATIVES, PROCEDURES FOR YOUR PRODUCTION AS WELL AS YOUR USE AS PLANT GROWTH MODULATORS AND FUNGICIDES.

1,2,4-TRIAZOLO (4,3-A) CHINOLIN-1 (2H) - ONE AND THESE CONNECTIONS TO the PHARMACEUTICAL USE.

NEW 1,2,4-TRIAZOL-DERIVATE a PROCEDURE FOR YOUR PRODUCTION AND IT ABSTENTION PHARMACEUTICAL COMPOSITIONS.

HYDROXYETHYL AZOL DERIVATIVES.

1-DIMETHYLCARBAMOYL-3-SUBSTITUIERTE-5SUBSTITUIERTE-1H-1,2,4-TRIAZOLE.

AZOLYLPROPENYL AND AZOLYLMETHYLOXIRAN DERIVATIVES AND THIS CONTAINING FUNGICIDES.

MIKROBIZIDE 1-FLUOR-1-AZOLYL-2,2DIARYLETHANDERIVATE.

1-AZOLYL-2-ARYL-3-FLUORALKAN-2-OLE AS MIKROBIZIDE.

FLAVORS-SE-RESTRAINING 1,2,3-TRIAZOL-1-YL, TETRAZOL 1-YL AND TETRAZOL-2-YL-VERBINDUNGEN.

2 (N-SUBSTITUTING GUANIDINO) - 4HETEROARYLTHIAZOLE AS MEANS AGAINST ULCERS.

SUBSTITUTED HYDROXYALKYL AZOLE, PROCEDURE FOR YOUR PRODUCTION AND YOUR USE AS ANTIMYKOTIKA.

PROCEDURE FOR the PRODUCTION (+) - ANTIPODES (E) - 1-CYCLOHEXYL-4,4-DIMETHYL-3-HYDROXY-2 (1.2, - TRIAZOL-1-YL) - PENT-1-ENS.

TRIAZOL DERIVATIVES AS ANTIFUNGALE MEANS.

6 (SUBSTITUTED METHYLEN) PENEME.

ADDUCT ALDEHYDE AND ITS APPLICATION IN THE PRODUCTION OF VITAMIN D DERIVATIVES.

TRIAZOL CONNECTIONS, PROCEDURES FOR YOUR PRODUCTION AND YOUR USE AS FUNGICIDES AND PLANT GROWTH MODULATORS.

(2-CYAN-2-OXIMINOACETYL) - AMINO ACID DERIVATIVES.

TRICYCLI AROMATASEHEMMER.

1,5-DIPHENYL-1,2,4, - TRIAZOL-3-CARBONSAEUREDERIVA E TO the PROTECTION OF CULTIVATED PLANTS FROM the PHYTOTOXIC EFFECT OF HERBICIDES.

SALTS OF THE PHOSPHOROUS ACID, YOUR COMPOSITIONS AND YOUR USE AS FIREPROOF ACTIVE SUBSTANCES.

ETHER DERIVATIVES OF SUBSTITUTED ONE 1-HYDROXYALKYL AZOLEN, PROCEDURE FOR YOUR PRODUCTION AS WELL AS YOUR USE AS FUNGICIDES AND PLANT GROWTH MODULATORS.

BIOLOGICALLY ACTIVE TRIAZOLYL DERIVATIVES.

NEOPENTYL PHENETHYLTRIAZOLE ONE, PROCEDURE FOR YOUR PRODUCTION AND THIS CONTAINING FUNGICIDES.

FUNGICIDES TRIAZOLE.

SUBSTITUTED AMIDE DERIVATIVES, PROCEDURE FOR THEIR PRODUCTION, THESE CONTAINING PESTICIDES COMPOSITIONS AND USE AS PFLANZENUND MUSHROOM FIGHT MEANS.

ANTIFUNGI DI (AZOLYL) PROPANOL DERIVATIVES.

SUBSTITUTED 1-AZOLYL-BUTAN-2-ONE, PROCEDURE FOR YOUR PRODUCTION AND YOUR USE AS FUNGICIDES AS WELL AS INTERMEDIATE PRODUCTS.

3,5-DIPHENYL-1H-1,2,4-TRIAZOLE WITH PREGNANCY-INTERRUPTING EFFECT, THEIR PHARMACEUTICAL COMPOSITIONS AND PROCEDURES FOR YOUR PRODUCTION.

MIKROBIZIDE ECYL ANILINE AND ACYLNAPHTHYLAMINDERIVATE, PROCEDURE FOR THEIR PRODUCTION AND YOUR USE.

TRIAZOLVERBINDUNGEN, PROCEDURE FOR YOUR PRODUCTION AND THIS CONTAINING FUNGICIDES.

MEANS AND PROCEDURE FOR PROTECTING PAINTING, WOOD AND OTHER NON--LIVING ORGANIC SUBSTRATES FROM THE DECLINE BY MICROORGANISMS.

ALPHA AZOLYL KETO DERIVATIVES, PROCEDURES FOR YOUR PRODUCTION AND YOUR USE AS FUNGICIDES.

1 (TRIHALOGENMETHYL SULFENYL) - 4-ARYL-1,2,4TRIAZOLIDIN-5-ONE, PROCEDURE FOR YOUR PRODUCTION, THIS CONTAINING FUNGICIDES AND PROCEDURES FOR the FIGHT AGAINST MUSHROOMS WITH THESE CONNECTIONS.

PROCEDURE FOR the PRODUCTION OF NEW ONES 1 (1,3DIOXOLAN-2-YLMETHYL) - 1H-IMIDAZOLEN AND -1H-1,2,4 TRIAXOLEN AND THEIR SALTS

PROCEDURE FOR the PRODUCTION OF NEW ONE 1,1DIPHENYLAETHEN-DERIVATEN

ARYLMETHYLAZOLE AND THEIR SALTS, PROCEDURES FOR THEIR PRODUCTION, IT CONTAINING MEANS AND YOUR USE.

THIOFORMAMIDINE, PROCEDURE FOR THEIR PRODUCTION AND THEIR APPLICATION AS DRUGS.

ALPHA-ARYL-ALPHA-PHENETHYL-1H-1,2,4-TRIAZOL-1PROPAN-NITRILE.

PROCEDURE FOR ISOMERIERUNG FROM SYMMETRICAL TRIAZOLEN TO ASYMMETRICAL TRIAZOLEN.

HÄMOREGULIERENDE PEPTIDE.

TRIAZOLDERIVATE, THEIR PRODUCTION AND USE AS PESTICIDES.

HETERO-CYCLIC DISULPHIDES, PROCEDURES FOR YOUR PRODUCTION AND PHARMACEUTICAL MEANS, THESE CONNECTIONS CONTAINING.

SUBSTITUTED AZOLYLMETHYL CYCLOPROPYL CARBINOL DERIVATIVES.

TRIAZOLYL AND IMIDAZOLDERIVATE AS WELL AS THESE CONTAINING PHARMACEUTICAL PREPARATIONS.

AZOLYL ALKENONE AND - OLE, PROCEDURE FOR YOUR PRODUCTION AS WELL AS YOUR USE AS PLANT GROWTH MODULATORS AND FUNGICIDES.

1,2,4-TRIAZOLYLPROPANOLE, YOUR PRODUCTION AND USE.

CHINOLONE AS INOTROPIC ACTIVE SUBSTANCES.

FUNGICIDES TRIAZOLE.

3-SUBSTITUIERTE 1-AZOLYL-3-METHYL-1-PHENOXY-BUTAN-2-ONE AND - OLE, PROCEDURE FOR YOUR PRODUCTION AND YOUR USE AS FUNGICIDES.

MORE TRIAZOLYLETHER CONTAINING MEANS FOR THE ADJUSTMENT OF PLANT GROWTH, PROCEDURE FOR THE PRODUCTION OF THE MEANS AND PROCEDURES FOR THE ADJUSTMENT OF PLANT GROWTH.

PLEUROMUTILIN DERIVATIVES, YOUR PRODUCTION AND IT ABSTENTION PHARMACEUTICAL COMPOSITIONS.

ALPHA AMINOPHENYLESSIGSAEUREDERIVATE ONE FOR USE WITH THE TREATMENT OF INFLAMMATIONS AS WELL AS NEW ONE ALPHA AMINOPHENYLESSIGSAEUREDERIVATE ONE.

PROCEDURE FOR THE PRODUCTION OF POLYCYCLI NITROGENOUS CONNECTIONS.

MORE CARBINOLETHER, PROCEDURES FOR YOUR PRODUCTION AND THIS CONTAINING FUNGICIDES.

N-AZOLYLESSIGSAEUREANILIDE ONE, PROCEDURE FOR YOUR PRODUCTION AND YOUR APPLICATION AS HERBICIDES.

TRIAZOLYLKARBAMATE, PROCEDURE FOR YOUR PRODUCTION AND YOUR USE.

N-SUBSTITUTING HETEROCYCLEN, PROCEDURE FOR YOUR PRODUCTION, AND IT CONTAINING DRUGS.

1,2,4-TRIAZOL-1-YL-VERBINDUNGEN, THEIR PRODUCTION, FUNGICIDES, PROCEDURES FOR the PRODUCTION OF FUNGICIDES AND PROCEDURE FOR the FIGHT AGAINST FUNGI.

HALOGENIERTE 1-AZOLYL-1-F of LUORPHENOXY BUTANe DERIVATIVES, PROCEDURES FOR THEIR PRODUCTION, IT CONTAINING FUNGICIDES MEANS AS WELL AS YOUR USE AS FUNGICIDES.

1-VINYLTRIAZOL-DERIVATE, PROCEDURE FOR YOUR PRODUCTION AS WELL AS YOUR USE AS GROWTH MODULATORS AND FUNGICIDES.