PROCEDURE FOR the PRODUCTION OF NEW ONES 1 (1,3DIOXOLAN-2-YLMETHYL) - 1H-IMIDAZOLEN AND -1H-1,2,4 TRIAXOLEN AND THEIR SALTS

The invention concerns the production of new 1 (1,3-Dioxolan-2-y] methy]) - LH-imidazo] EN and -1H-1,2, tl-triazolen and their salts, which are suitable inshesondere for the fight of pathogener mushrooms and bacteria. Into the US-PS Nr.3, 575.999 and Nr.3, 9360 470 and in the BE-PS Nr.835579 is 1 (1,3-Dioxolan5-2-ylmethyl) - LH-imidazole and - IH-10 20 4-triazole also described for the fight against felt and bacteria suitable characteristics. From these connections available the according to invention connections differ substantially by the kind of the substituent in the 4-Stellung of the Dioxo] angruppe. Gemäht of the invention become new IH-Imidazolund IR-l, Z, 4-TriazoI-Derivate of the general formula N IL j Q “OH A -0-- R (1) and their salts with acids as well as their stereoisomers created, whereby Q mean a nitrogen atom or a Methingruppe, acre one if necessary up to 3 substituent asking Pheny] group, whereby the Substituentengleieh is different or and a Balogenatom, a Niederalkyloder Niederalky] oxyrest represent, A either a) a Isothiocyangruppe of the formula - N=G=S (A) or b) a Aminorest of the general formula (B) e) in the Rx and R= same or different are and a hydrogen atom or a Niedera] kylrest represent in each case, or a remainder of the general formula X - NH-C (Y) m-R3 in the X a Sauerstoffoder Schwefe] atom, Y an oxygen atom or a group of NR, m the number of 0 or I and (C) R-S a hydrogen atom, a Niedera] kyloder bionooder Dihalogenniederalkylrest or one up to 2 substituents carrying Phenylgruppe represent if necessary, how the substituents to the Phenylgruppe same or different are and in each case ttalogenatom, a Niederalkyloder Niederalky! oxyrest, under the condition that if X a Schwefe] atom represent, Y mean a group of Niles and an m the number of 1 mean, and if Y represent an oxygen atom and an m the number of 1, does not mean RA a hydrogen atom, or c) a remainder of the general formula /---- \ (D) IO - N z, in which Z represents a direct connection, an oxygen atom, a group of groupgroups or a group of the general formula =N-R, whereby R a hydrogen atom, a Niederalkyl, Hydroxyniederalkyl, Niederalky] oxyniederalkyl, Niederalkanoyl, Niedera] kylsulfonyl, Niederalkyloxycarbonyl, Niederalky] - oxycarbonylmethyl, Monound Diniederalkylaminocarbonyl, Niederalkylaminocarbonylmethyl, Niederalky] aminothioxomethyloder Niedera] kylthiothioxomethylrest or a Phenylmethylsulfonyl, Phenoxycarbonyl, Aminocarbonyl, AminocarbonylmethyI, phenyl, Phenylmethyloder one if necessary up to 2 substituents carrying Benzoy] group meant, whereby the substituents to the Benzoy] group same or different are and a halogen atom, one Niederalkyl or Niederalkyloxyrest represent, and R a hydrogen atom or a Nitrogruppe, whereby A represents an amino group, if B means a Nitrogruppe. In this connection “Niederalkylrest” is a normal or branched hydrocarbon remainder with I to 6 carbon atoms under the expression, how methyl, ethyl, 1-Methyläthy! -, 1.1 ' - DimethyläthyI, Propyl, Buty] -, Penty] - and Hexylgruppe, under which expression “Niederalkanoylrest” a normal or branched Alkanoylrest with 1 to 6 gohlenstoffatomen, like S0 the Formy] -, Acety] - to understand, Propanoyl, 2-Methylpropanoyl, Butanoyl, Pentanoylund Hexanoylgruppe, and by the expression “halogen atom” a halogen atom with a Atomgewich.t about under 127, like the fluorine, chlorine, Bromund iodine atom, of the connections of the general formula (I) are preferential such, for which in this formula Q a Methingruppe and a R mean a hydrogen atom. The connections are particularly preferential, for which in the formula mentioned acre means a Monooder Dihalogenphenylrest, preferably the 2,4-Diehlorphenylgruppe. In order the structure of the connections of the general formula (I) of certain basic materials and of intermediate products more simply to represent to be able, the 2-Ar-2 (1H-Imidazol-i-yl methyl becomes following} - 1, S-dioxol an-4-yloder - (1tt-1,2,4-triazol-l-ylmethyl) - l, designated 3-dioxol an-4-ylrest with D, how is in the following indicated. Q = CH or N CH2 acre I I (D) I0 in that managing for CD) indicated general formula has acre the meaning indicated above. The new connections of the general formula (I), their salts and by the fact it is kept according to invention to stereoisomers that one a connection of the general formula D-CR2-W, (II) in the D the remainder of the general formula N I CH2 O _Ar I I (II') meant, in which Q and acre have the meaning indicated above, and W a reactive ester remainder to represent, with a connection of the general formula HO Al (III} R converts, in A a remainder of the general formula {b}, a remainder of the general formula IC) (whereby R does not mean a hydrogen atom, if m represents the number of 1} or a remainder of the general formula {D} means, in which R does not represent HydroxyniederaIkylrest, and R the meaning indicated above has, z0 whereby if necessary Aminooder Piperazinylgruppen by a group of protection of P, e.g. Niedera] kanoy] - or Niederalky] oxyreste, is protected, and hiebei a connection of the general formula D-CH2, R manufactures if necessary and a) a received connection of the general formula (I-A) D-CH2 -0/ ---- NH2 in the D the understanding meaning has, into which appropriate Isothiocyanat of the general formula (I-A-i “) (I-b) transfers, in which D the managing meaning has, and if necessary to the production of a connection of the general formula S D-CH= -0 NH-C-NH2 (IC} I0 bi in the D the managing meaning has, which received connection of the general formula (l-b) in a solvent with ammonium hydroxide converts, or for the production of a connection of the general formula D-CH= -0 X (ID) in the D, X and RA the understanding meaning to have, whereby X represents an oxygen atom, if R means a hydrogen atom, a received connection of the general formula (I-a-1”} in an inert solvent with a connection of the general formula Rs-N=C=X (IV) o heated up, in which X a Sauerstoffoder Schwefe] atom represents and R-S the managing meaning has, or for the production of a connection of the general formula o • II ever--NH-C (O) m-r D-CH, - 0 -- …. (IE) d) in the D, the m and B3 the understanding meaning have, a received connection of the general formula (i-A-1') with treat, or for the production of a connection of the general formula D-GH = -0 X a Acy] ierungsmittel (I-f) in R-S a hydrogen atom or a Niederalky] remainder represents and D and X the evenly indicated meaning to have, a received connection of the general formula Nr.366683 RST degrees - o n---A-%=7” - \ 1” (l-a-2) in the D the understanding meaning has, in a solvent with a connection of the general formula Bs - N=C=X (V) heated up, in which X a Sauerstoffoder sulfur atom means, with which condition that X represents an oxygen atom, if Bs means a hydrogen atom, and im übrigen Bs has the understanding meaning, and if necessary for the production of a connection of the general formula (l-g) in B a Niederalkyl, Hydroxyniedera] kyl, Niederalkyloxycarbonylmethy] -, Aminocarbonylmethy] -, Niedera] kylaminocarbonylmethyloder Phenylmethy] remainder represents and D the understanding meaning has, a received connection of the general formula (I-a-2} with one reactive ester of of the general formula W-B' alkylates, in which W and R meaning have the understanding, or to the production of connections of the general formula (industrial union}, in which “a Hydroxyäthylgruppe means, a received connection of of the general formula (I-a-2} with Äthy] enoxyd converts, or for the production of connections of the general formula (industrial union}, in which R” a primary or secondary Niederalkylrest or a Phenylmethyl - group means, a received connection of the general formula (I-a-2) in presence of a catalyst and a base with an appropriate aldehyde or Keton reductively aminiert, or for the production of connections of the general formula (industrial union}, in the B' ] aminocarbonylmethylrest, a received connection of the general formula (industrial union}, in which B' represents a Niederalkyloxycarbenylmethylrest, with an appropriate Niederalkanamin converts, or if necessary for the production of connections of the general formula (I-h} in the D the managing meaning has and R” a Niederalkanoyl, Niederalkylsu] fonyl, Phenylmethylsulfonyl, Niederalkyloxycarbony] means a Niederalky -, Phenoxycarbonyl, Aminocarbonyloder Monooder Diniederalky] aminocarbonylrest or a Benzoylgruppe substituted if necessary represents, a received connection of the general formula (I-a-2) treated with a Acy] ierungsmittel, or to the production of connections of the general formula D-CH2-O S IL o s ioderalkyl (Ii) in the D, I0 has the managing meaning a received connection of the general formula (I-a-2) in a solvent with carbon disulfide and an appropriate alkylating agent treats, or e) for the production of connections of the general formula (1), meant in The general formula (D), in which Z represents a remainder of the general formula =N-R and R a Niederalkyloxyniederalkylrest means, the received appropriate hydrexyniederalky] substituted connection of the general formula (I-A) alkylated and/or if necessary the received connection with an acid into a salt or in another Stereeisomeres transfers. In the managing general formula (IL) W means a reaktiensfähigen ester remainder, like a ha] ogenatom, a Methylsu] fonyloxy or 4-Methylphenylsulfonyloxygruppe. The aforementioned conversion can take place in usual way in accordance with well-known procedures for O-alkylation, for example via common agitating of the reaction partners at somewhat increased temperature in presence of a suitable base and in an appropriate inert organic solvent, like in 4-Methyl-2-pentanon, N, N-dimethylformamide, N, N-Dimethylacetamid and Dimethylsulfoxyd. As solvents also mixtures of the RST singing means mentioned with aromatic hydrocarbons can do beispie] sweise, as benzene and methyl benzene are used. Appropriate bases are for example Alkalimetal] - and alkaline earth metal carbonates, - of hydrogencarbonates and - hydrides, like Natriumcarbonat, Natriumhydrogencarbonat, Ka] and sodium hydride iumcarbonat. If meant a Aminorest of the general formula (B) in the aforementioned formula to begin (I-A) the remainder of A, in that at least one of the remainders of R, and R2 a hydrogen atom represents (see-following formula I-A-l) or a unsubstituierte l-Piperazinylgruppe (see following formula I-a-2), is appropriate it, in the aforementioned conversion a phenol of the general formula (III), in that Amino and/or. Piperazinylgruppe by an appropriate group of protection of P is protected (see following formulas Iii A and Iii b). Thus a WELL is avoided] kylierung. From the received connections (see following formulas I-a-3 and I-a-4) the group of protection P can in usual way abgespalten to become. Suitable groups of protection are for example Niedera] kanoylund Niederalkyloxycarbonylreste, which by alkaline hydrolysis easily abgespa] ten will can. (II) + HO (g 1 < \ N-Poder > D-CH2-0 R2] R (Iii A) R, or 1 R (I-a-3) OH D-CH2-0 NH (R R [I-A-l) or R) (II) + HO--/ --N -- /N-P D-CHI-O -- NP (Iii b) (I-a-4) OH ùD-CH =-O (I-a-2) connections of of the general formula (I), in which A a group of ISO cyanogens (remainder of of the general formula a) meant (see following formula I-b), can easily from connections of a]] common formula (I-A-l) to be manufactured, in the H, or R= and R a hydrogen atom mean (see. following formula I-A-l!). In usual way as with the production of Isothiocyanaten from amines one proceeds. For example a connection of the general formula (i-A-1') with Schwefelkoh] is converted enstoff in Pyridin in presence by N, N' Methantetraylbis (cyc] ohexanamin). (i-A-l') Pyridin D-CHI-O N=C=S (I-b) connections of of the general formula (I), in A a Aminothiocarbony] amino group (remainder of the general formula (C), in which X mean a sulfur atom, Y a NH-group, m the number of 1 and R-S a hydrogen atom) can by shifting of the appropriate connection of the general formula (I-b) with ammonium hydroxide in a solvent, like in a Niederalkano], for example in 4ethano] or Äthano], to be manufactured. CH3OH (I-b) + NH OH D-CHz-o s NH-C-NH= (IC) connections of the general formula (I), in which A a remainder of of the general formula (C) meant, in which Y a NH-group and an m the Zah1 1 mean, as well as, if R-S represents a hydrogen atom, X an oxygen atom meant, know in a simple manner by shifting of of an appropriate amine of of the general formula (i-A-l') with an appropriate isocyanate or Isothiocyanat of of the general formula (IV) to be manufactured. (l-A-l') + R3 - N=C=X X - D-CH= -0 NH-C-NH-R-S (IV) {ID) the managing conversion can take place in usual way, for example via common agitating of the reaction partners, preferably under simultaneous heating up, in an inert solvent, as 1,4-Dioxan. If B8 mean a hydrogen atom and with it the connection of the general formula (IV) cyanic acid or ISO cyanic acid, it is to be used appropriately, an appropriate Alka] imetal] cyanat in aqueous solution and in the following the free acid by treating with an appropriate acid, how acetic acid, to set free. Connections of the general formula (I), in which A a remainder of of the general formula (C) meant, in which and Y in each case an oxygen atom as well as R-S and m the managing meaning I0 have X, know by Acy] ieren an appropriate amine of the general formula (i-A-l') with appropriate acylation center] in accordance with usual procedures to the N-Acyllerung to be manufactured. Suitable Acy] ierungsmitte] for the production of connections of the general formula (IE), in which m the number 0 means, are Acy] of halides and - anhydrides, derived from the acid Rù COOH, as well as the acid, whereby the latter for the Formylierung is preferential. Meant to the Herstell5 lung of connections of the general formula (IE), appropriate Koh knows o in the m the number of 1] ensäureha] ogenide (Carbonohalidate), preferably Kohlensäurech] oride (Carbonochloridate) and Di-Rù-carbonate to be used. Acylation (I-A-i ') - D-CH2 - O 0 // II < --NH " C (0) m-Rù (IE) connections of the general forms! (I), meant in which A a remainder of the general formula (D), in which Z a remainder of the general formula NR represents, whereby R a Aminocarbonylgruppe, a Niedera] ky] aminocarbonyloder Niedera] ky] aminothiocarbonylrest meant, are in the following form] g] measuring as the general formula (I-f) indicated, in R-S a hydrogen atom or a Niedera] kylrest meant. These connections can be meant, made of a Piperazinderivat of the general formula (I-a-2) by shifting with an appropriate isocyanate or Isothiocyanat of the general formula (V), in that X a Sauerstoffoder Schwefe] atom, how X an oxygen atom darste! lt, if R-S means a hydrogen atom. The procedure corresponds the aforementioned Herste] lungsweise of connections to the general formula (ID) from connections of the general formula (i-A-l') and (IV). (I-a-2) + R5-N=C=X: D-CH =-0 X N \ f-o-Nù-Ro (V) {I-f) connections of the general formula (I), in which A a remainder of the general formula (D) meant, in Z a remainder of the general formula NR represents and R a Niederalkyl, Hydroxyniederalkyl, Niedera] kyloxycarbonylmethy] -, Aminocarbonylmethyl, Niederalkylaminocarbony] methy] - or Phenylmethylrest meant (R4 is replaced in the following formula by R), can by alkylating a connection of the general formula (I-a-2) with an appropriate reactive ester of the general formula (VI), in which W and B' the understanding meaning have, in accordance with which usual procedure for N-alkylation are manufactured. (I-a-2) + W-R - D-CII2 - O [vi) (industrial union) if R in the general formula (industrial union) a Hydroxyäthylrest meant, can be manufactured these connections also by shifting of a connection of of the general formula (I-a-2) with ethylen oxide, for example by Hindurchl¢iten of the latter by a hot solution of the connection of of the general formula (I-a-2) in a suitable organic solvent, like a low Alkanol, for example methanol, an ethanol or a 2-Propanol. If R in the general formula (industrial union) means a primary or secondary Ni¢deralkylrest or a Phenylmethylgruppe, these connections know also by reductive Aminierung from an appropriate connection of the general formula (I-a-2) and a suitable aldehyde or Keton to be manufactured. For example a mixture of the reaction partners in an inert organic solvent, like a low Alkanol, for example methanol or an ethanol, in presence of a catalyst, like palladium up Itolzkohle, becomes and an appropriate base, as Natriumacetat treats, with hydrogen. Connections of the general formula (industrial union), in which R " one (Niederalkyl) - amincarbonylmethylrest means, can also from the appropriate connections of the general formula (industrial union) be received, in R " a Niederalkyloxycarbonylmethylgruppe represents, by shifting of the latter connections with an appropriate NiederaIkylamin in accordance with usual procedures for the production of amides from esters. Connections of the general formula (I), in which A a remainder of the general formula (D) meant, in Z the remainder of the general formula NRù represents and Rù a Niederalkanoyl, Niederalkylsulfonyl, Phenylmethy] sulphonyl, Niederalkyloxycarbonyl, Phenoxycarbonyl, Aminocarbonyloder Monooder Diniederalkylaminocarbonylrest or a Benzoylgruppe substituted if necessary meant (Rù is indicated in the following formula equation as R "), can be hergesteIlt in a simple manner by Acylieren of an appropriate connection of the general formula (I-a-2) with an appropriate acylation means in accordance with usual procedures for the N-acylation. Generally this acylation is accomplished by shifting of the connection of the general formula (I-a-2) with an appropriate acyl halide, which is derived from the appropriate Carbonoder sulfone acid. If the acyl group a Niedera which can be introduced kanoylrest or a Benzoylgruppe substituted if necessary represents, the acylation with an anhydride of the appropriate acid takes place or with the acid, whereby the latter with the Formylierung is preferential, represents the acyl group a Niederalkyloxycarbonylrest or a Phenoxycarbonylgruppe which can be introduced, can as Aeylierungsmittel also an appropriate Diniederalkyloder Diphenylcarbonat be used. Acylation (I-a-2): D-GH2-O (I-h) connections of the general formula (I-h), in which H a Niederalkanoylrest mean, can if necessary with an appropriate Beduktionsmittel, how Lithiumaluminlumhydrid are reduced, for the appropriate connection of the general formula (industrial union), in R one to “- carbon atom normal Niedera] kylrest means. Connections of the general formula (I), in which A a remainder of the general formula (D) meant, in which Z a remainder of the general formula N-Rù represents and Rù one (Niederalkylthio) - - thioxomethylrest meant (see following general formula Ii), can by shifting of a connection of the general formula (I-a-2) with Schwefelkoh] enstoff and an appropriate alkylating agent to would bring the Niederalkylrestes, e.g. with a Diniederalky] sulfate in, in a solvent, like a mixture of a low Alkanol, for example methanol, and a water, to be made. (I-a-2) + CS= + alkylating agent D-CH, - O S (Ii) connections general formula (I}, in which A know a remainder of of the general formula (D) meant, in which Z represents a remainder of the general formula N-Rù and Rù a Niederalkyloxyniederalkylrest means, easily of the appropriate hydroxyniederalkylsubstituierten connection by alkylating in accordance with the latter usual procedures for O-alkylation are made. An appropriate procedure is managing for the production of the connections of the general formula (I-A} from the connections of the general formulas (II) and (III} described. The parent compounds of the general formula (II}, meant in the Q a Methingruppe, and procedures for their production, are descriptive in the BE-PS Nr.837831. Generally the reactive esters of the general formula (II) from an appropriate 1-Ar-220-Bromäthanon of the general formula (VII) can (see following formula equation} by Retalisieren with 1,2,3-Propantriol and following treatment of the reaction product in accordance with Synthesis 1974 (I), S.23, to be manufactured. Preferably both reaction partners become together several hours under Rückf] uß in an appropriate organic solvent. preferably in presence of a simple alcohol, like ethanol, Propanol, butanol and Pentanol, heats up, whereby water in form of a azeotropen mixture is separated. The conversion takes place also in presence of a suitable strong acid, like 4-Methylbenzolsulfonsäure. Suitable ones organic solvents for the reaction system are for example aromatic hydrocarbons, like benzene, methyl benzene and Dimethylbenzol, as well as satisfied I< ohlenwasserstoffe, like cyclohexane. The received Dioxolan of the general formula (VIII) will is treated with Benzoylchlorid to the appropriate Benzoat of the general formula (IX} converted, which then with 1H-Imidazol or 1H-1,2,4-Triazo]. The reaction is accomplished preferably by common agitating and heating of the reaction partners up in an organic solvent, for example in N, N-dimethylformamide, in presence of a suitable strong metal base, like Natriummethanolat. The received Zwisehenprodukt of the general formula (X) in alkaline medium first one hydrolyzes. Subsequently, the hydroxyl group is transferred of the received connection of the general formula (XI) in usual way into a reactive group of esters. For example the appropriate Methansu] fonate and 4-Methylbenzo] sulfonate is converted simply by shifting of the appropriate alcohol with Methansulfenylchlorid or 4-MethylbenzolsulfonyIchlorid. The appropriate Ba] ogenide can be received to Phosphorpentach by shifting of the alcohol with the appropriate Halogenierungsmitte], for example with CSU] fury] CH] orid,] orid, Phosphorpentabromid and Phosphory] chIorid. If the reactive ester represents an iodide, this is preferably manufactured by manufacturing the appropriate chloride or bromide and following exchange of the halogen by iodine. The aforementioned conversions are described by the following reaction equations: f -- 0 G 0 0 G 7 J J J • \ _ & 6e' many parent compounds of the general formula (Ill) are well-known. The remaining can generally from the Aminophenolen and (l-Piperaziny]) - phenolen in actually well-known way and in that managing described way for the production of of the necessities remainders of A in the connections of of the general formula (1) to the connections of of the general formulas (I-A-l) and (I-a-2) to be manufactured. If pheno] ische hydroxyl group with these syntheses disturbs, is it appropriate to block this group first with a suitable group of protection which then later again abgespa] ten becomes. For example the protected phenol in form of a Methoxyverbindung can be present, whereby the Methoxygruppe at the end by treating with an appropriate strong acid, like with hydrobromic acid, into which appropriate hydroxyl group leads überlO becomes. As if blocked connection are suitable also Acy] oxyverbindungen, from which the acyl group by alkaline hydrolysis abgespalten later becomes. The connections of the general formula (1) their substantial characteristics exhibit also in form of its salts and can be transferred therefore with inorganic or organic acids into the appropriate salts. Examples of inorganic acids are has] ogenwasserstoffsäuren, like CH] orwasserstoff, Bromwasserstoffund hydriodic acid, sulfuric acid, Ss] Peter acid, Thiooyansäure or a Phosphorsäuro. Examples of organic acids are vinegar, prop. ion, Bydroxyessig, 2-Hydroxypropion, 2-OxopropJon, thandicarbon, Propandicarbon, 1,4-Butandicarbon, Z-2-Butendicarbon, E-2-Butendicarbon, 2-14ydroxy-1,4-but andicarbon, 2,3-Dihydroxy-l, 4 - - butandicarbon, 2-Hydroxy-l, 2,3-propantricarbon, Benzoe, 3-Pheny] - 2-propencarbon, - Hydroxybenzo] vinegar, Methansu] fon, Æthansu] fon, 2-Hydroxyäthansulfon, 4-Methy] benzo] sulfone, 2-Hydroxybenzoe, 4-Amino-2-hydroxybenzoe, 2-Phenoxybenzoeund 2-Acetyloxybenzoesäure. The received salts are led back in reverse by treating with an appropriate free base, for example by shifting with one alka] ischen connection, like Natriumoder I/O] iumhydroxyd, into the appropriate free bases. Exhibit enstoffatome from the general formula (I) is evident that producible the according to invention connections at least two asymmetrical Koh], which itself to the 2und of the 4-Stellung of the Dioxo] anchoring find. These connections can therefore be present in form of different stereoisomers. The diastereomeren Racemate (in accordance with cisoder Iran form into the C.A., Bd.76, index Guide, SectJon IV, S.85, descriptive rules) of the connections of the general formula (I) can be separated in usual way. Suitable methods are for example the selective Kristal] isation and the chromatography, e.g. the Säu] enchromatographie. There the stereochemical configuration already in the intermediate products of the general formula to accomplish (II), is possible it is given to separate cisund the trans form already in this stage or still in former times from each other and only then the conversion for the connection of the general formula (I). The separation cisund the trans forms of such intermediate products can take place also in the aforementioned way. Cisund trans diastereomeren Racemate can for their part in usual way in their optical isomers cis (+), cis (-), trans (+) and trans (-) to be separated. 0 dia. connections of the Al] gemaænen Forma] (I) and bre salts with Säugen are valuable active substances for the fight against pi] zen and bacteria. The connections are in relation to many different pi] zen effectively, for example opposite Microsporum canis, Ctenomyces of mentagrophytes, Trichophyton title, Phia] ophora verrucosa, Cryptococcus neoformans, Candida tropicalis, Candida A] bicans, Mucer of species, Aspergi]] US fumigatus, Sporotrichum schenckii and Sapro] egnia species. Examples of bacteria, opposite which the connections of the general formula (1) are effective, are Erysipe] otrix insidiosa, Staphy] ococci, like Staphy] ococcus hemo] yticus, and Streptococci, like Streptococcus of pyogenes. Because of their strong local and systemic antimlkrobie] len effectiveness according to invention the herste]] cash connections represents these valuable active substances for the destruction or prevention of the growth of pi] zen and bacteria. The strong antimikrobiel] e effectiveness of the connections of the general formula (I) is shown by the following attempts. Attempt A effectiveness of the connections of the general formula (1) against vaginale Candidosis with rats female Wistar Batten with a Körpergewieht of about in each case 100 g are ovariectomiert and hysterectomiert. 3 weeks after the interference are given to the rats during 3 weeks once weekly 100 pg Oestradiel Undecy] RK in Sesamöl subcutan. In such a way induced Pseudooestrus is controlled by microscopic investigation of Vaginalabstrichen. Fodder and water are at will offered to the animals. The rats are infected intravaginal with B x I0s cells diluted by Candida albicans (grown on a l0 Sabouraud Brühe during 48 h at a temperature of 37°C and with a Natriumch] orid] ösung). The day of the infection varies as a function of the occurrence of the signs on induced pseudo OesLrus on 25. up to the 32.Tag after the operational interference. The active substances which can be examined are gt on two days (on the basis of the day of the infection) once daily orally verabfo]. For each attempt Kontrollversucha with a placebo are accomplished. On different days after the infection with sterile Tupfern Vaginalabstriche are made. The Tupfer is given in Petri plates to a Sabouraud Brühe and there 48 h at a temperature of 37°C are inkubiert. As far as no growth of Candida A] bicans takes place, i.e. if the animals at the end of the attempt are negative, this is to be due to the administration of the active substance, since an absence of the growth of the Mikreorganismus in the case of the samples treated with a Z0 placebo is not observed. In the following tables the lowest oral dose of the examined active substance is indicated I, II and III in each case, which is still effective at the 14.Tag after the infection. Attempt B effectiveness of the connections of the general formula (I) opposite Kropf Candidosis with Z5 Truthühnern 14 days old Truthühner become in the Kropf with 4 × 10e lines of Candida albicans (bred as infected for attempt A). The volume of the Inocu] around amounts to I rel. The active substance which can be examined is before-mixed in 500 mg Lacton and interfered then in 1000 g flour without further additives. The concentration of the active substance in the flour is expressed in mg/kg. The prepared fodder is given to the depths on 13 following each other days, beginning with the day of the infection. Subsequently, the animals are removed for a sterile Natriumch killed, their Kropf, emptied and ground in a Ultra Turrax mixer in 15 m]] oridlösung. On Sabeuraud agar one is made colony-toughly] ung. The results are summarized in the tables I, II and III, where the EDs0 - values are indicated, i.e. the respective dose of the active substance, with which bend from 50% of the examined animals regarding Candida A] bicans is completely negative. Table I N cls base or salt Vaginale Candldosls with rats lowest effective oral dose mg/kg Kropf CandldoGis with Truthühnern EDs “in mg/kg fodder - N =S base 5,125 - 15 - NR, 386683 - NHz /CH, - i CH, - NH-CHO - NH-CO-CH, - NH-CO-C2Hs - NH-CO-CH (CI) = - NH-CO-- ß--/- - F - N HC O--/- - ß--C1 - NH-CO-- Br - NH-CO--< OCH= - ùH-CO-O \ - NH-CO-Nh-CH - NB-CO-NH-C2H s - NB-CS-NH, - NH-CS-Nh-CH, base or salt Babette I (continuation) Vaginale Candidosls 5el rats lowest effective oral Oosis mg/kg Kropf Candidos£s with Truthühnern EOso £n m9 /kg fodder base 2 (COOH), H=O base base (COBH), (CH,), - CHOB base base base base base base HNO= base base base base base base lo 2.5 I0, i i 125 31 31 31 31 125 63 16 31 31 16 31 16 125,125 t25 125 - NE-CS-NH-C2Hs2Hs 0 _N/--\ NH - N r - CO-CH3 - Ne-CO-OCHs \ __/- N/N-CO-OCzH - N - CO-NH - n - N-CO-NH-CH” n--\ - \ of /N-CO-NH-C2Hs n---\ - _/N-CO-NH (CH2) 2 - CH3 - n “- “- C SH-CH 3 \ __/_N/-- _CR2_CH3 \ __/_N”/-- N_COO_CH 3 X__/base or salt table I (continuation) Vaginale Candldosls with rats lowest effective oral Oosis mg/kg Nr.366683 Kropf Candidosls with TruthBhnern EDso in mg/kg fodder base base base base base base base base base base. H2 0 base. H2 0 base. 2 H2 0 base. H2 0 2 (COOH) 2 2 HC] 2.5,2.5,2.5,2.5,2.5,2.5,2.5 1.25 2.5,125 16 16 125 16 125 16 125,125,125 31 table I (continuation) - N \ N-COO-C2 H s - Ne--” N-Ctlz1z-cH (Ctl s) z _N/--\ N_CH (CH3) z - N - BN (CH2) 3 - Ctt -1/I - (cH2) 2 - CH s - NH-CH z-CH - Ita-CH3 _N/--\ N_SO2_CH3 \ __/- n N-CH z-C6H _N/--\ N_SOz_CH2_CeHe _N/-- i_CH2_CO-NItz - NEN CHz CH 3/\ N_CH2_CöHs base or salt 2 Cl. I/2 HzO 2 (COOH) 2, CzHsOH 3 HCI. HzO 3 HC1. H2 0 base. z z/z (COOß) z base base base. HzO 3 HCI. HzO base base base base Vaginale Candidosls with rats lowest effective oral Oosls mg/kg Kropf Candldosis with Truthühnern Eßso in mg/kg fodder 2.5,2.5,2.5,2.5 1.25 2.5 1.25 < 2,5 1.25 31 16 31 31 31 18 R (CHz) s-CH3 CH (CH3) - CH2-CH3 CO-CzHs CO-O-C2Hs CHO CO (CHz) z-CB3 CH2-CH (CHs) z CH (CH3) 2 CO-O-CH3 SO - CH2-CsHs CO-Oh-CöHs {CHz) 2-CH3 CO-CH3 BH3 S02-CH3 CO-CeHe table II “-. J c1 N/ --C1/cis base or salt Vaginale Candidosls with Rallen niedrlgsLe wlrksaee oral Oosis mg/kg KropF andldosls bel Truthühnern EDso in mg/kg FuLLer base base 2 HCl 2 HCl base 2 HB1 base base base base. ffzB base base base base base. 1/2 HzO Bes 2.5 1.25 2.5,2.5 1.25 1.25 1.25 1.25 63 16 16 31 16 16 31 table III CH CH CH C CH acre 4-OCH3-CeH 4-OCH3-CeH 2,4-C12-CeH 2, “- C12-C “H3 1,4-C12-CsHs B-NHz 3-NO base or salt of isomer - 1/2 (L) - HOOC - CH=CH-COOH base cis HNO3 cis base C [s base Vaglnale Candldosls fuel element [rats nledrigsLe effective oral dose mg/kg 2.5,2.5,5.0 KropF Candidosls with Truthühnern OD in mg/kg fodder 31 63 I I Z CO Dic connections of the general formula tl) and their salts with acids can alone in each case or in combination, auGh in combination with other active substances, with usual carrier materials and/or diluents and/or auxiliary materials into valuable drugs for the fight of pathogener mushrooms or bacteria to be transferred. The examples describe the invention. Parts refer to the weight, as far as nothing else is indicated. Example 1: A mixture of 2,4 parts of n (4-Hydroxypheny]) - benzamid, 4.2 parts of cis-2 (2,4-Dich] orphenyl) - 2 (eat imidazol l ylmethyl) - l, 3-dioxolan-4-ylmethylmethansulfonat, 2 parts of Kaliumearhanat and I0 of 75 parts of Dimethy] sulfoxyd is agitated 16 to 18 h at a temperature of 100°C. The Beaktionsgemisch is then cooled down and poured in water. The received product is extracted twice with Trich] ormethan. The united Trich] ormethanextrakte twice with water is washed, then dried, filtered and evaporated. The arrears become from l-Butano! umkristal] isiert. The received connection is triert and dried abfi]. Yield of 2.7 parts of t51% d.Th.) a {4 - [2-t2,4-Dichlorpheny]) - 2 (IH-imidazo] - l-y] msthy]) - - I, 3-dloxolan-4-ylmethoxy] - pheny]} - benzamid of the Fp. 217,6°C. Example 2: In accordance with example l, however under employment of one quiva] entsn quantity of the appropriate substituted n (4-Hydroxyphenyl) - benzamids, the following Verbfndungen is received: Cis n {4 - [2 (2,4yDich] orpheny]) - 2-11H-imidazo] - l-y] methy]) - l, 3-dioxolan-4-ylmsthoxy] - pheny]} - -4-methoxybenzamid; Fp. 188,7°C. Cis n {4 - [2 (2,4-Dich] orpheny]) - 2 (IH-imidazo] - l-y] methy]) - I, 3-dioxo] an-4-y] methoxy] - phenyl} - -4-f] uorhenzamid; Fp. 198,2°C. Cis ethyl {4 - [2 (2,4-dich] orphenyl) - 2 (1H-imidazol-l-y] methy]) - i, 3-diexolan-4-y] methexy] - pheny] l - carbamat; Fp. 178,9°G. cis-4-Brom-N {4 - [2-t 2,4-dichlorphsnyl) - 2-t 1H-imldazol-l-y] methy]) - i, 3-dioxo] an-4-ylmethoxy] - - pheny]} - benzamid; Fp. 217,9°C. Example 3: A mixture from 2,8 parts of 4-Ch] or-n (4-hydroxypheny]) - henzamld, 0.4 parts of sodium hydride dispersion [7B%), 75 parts of Dimethylsulfoxyd and eat parts benzene I h at a temperature of 40°C one agitates. After the addition of 4,2 parts cis-2 (2,4-Dich] orpheny]) - 2 (IH-imidazol-l-ylmethyl) - l, 3-dioxo] an-4-y] methylmethansulfonat is agitated the mixture 16 to 18 h at a temperature of 100 “C, cooled down then and poured in water. The Beaktionsprodukt is extracted twice with benzene. The united Benzalextrakte is washed, dried, filtered and evaporated with water. The arrears are recrystallized from l-Butano]. The received connection is filtered off and getrecknet. Yield of 3.2 parts [58% d.Th.) of cis-4-Ch] or-n {4 [2 (2,4-dich] orpheny]) - 2 (iH-imidazo] - l-y] methy]) - I, 3-dioxo] an-4-y] methoxy] - phenyi} - henzamid; Fp. 213,3 °C. Beispie] 4: A mixture from 1,8 parts of 4 (l-Pyrrolidinyl) - pheno], 0.4 parts of sodium hydride dispersion 178%) and 100 parts of Dimethy] CSU] foxyd 1 h is agitated at a temperature of 40°C. After the addition of 4,2 parts of cis-2-t2,4-Dich] orphenyl) - 2 (IH-imidazo] - l-y] methyl) - l, 3-dioxolan-4-y] methy] - methansulfonat is agitated the mixture 16 to 18 h at a temperature of 100°C, cooled down then and poured in water. The reaction product becomes with 1,1 ' - Oxybisäthan extracts. The organic excerpt is washed, dried, filtered and evaporated twice with water. The arrears are recrystallized from l, l' Oxybisbutan. The received connection is filtered off and dried. Yield of 2.3 parts [48% d.Th.) of cis l {2-t2,4-Dichlorphenyl) - 4 [4-tl-pyrro] idiny]) - phenoxymethy]] - I, 3-dioxolan-2-ylmethyl l-IH-imidazo]; Fp. 149, I°C. so example 5: A mixture from 1, flat steel bar parts of 4 (4-Morpholinyl) - phenol, 4.2 parts of cis-2 [2,4-DiGhlorpheny]) - -2-11 H-imidazol-l-y] methyl) - I, 3-dioxol an-4-ylmethylmethansu] fonat, 2 parts of Ka] iumcarbonat and B0 parts of 4-Methy] - 2-pentanon heated up under agitating 16 to eat h under return flow. The reaction mixture is cooled down, shifted with water and extracted twice along l, l' Oxybisäthan. The united organic excerpts are dried, filtered and evaporated. The arrears are gereingt by Säulenchromatographie at Kieselge] using chloroform as Elutionsmlttel. The pure parliamentary groups are collected, and that Elutionsmittel is abdestilliert. The arrears become from 1,1 ' - Oxybisbutan recrystallizes. Yield of 2.3 parts (47% d.Th.] cis-4 {4 - [2 (2,4-Dichlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - - I, 3-dioxol an-4-ylmethoxy] - phenyl l-morpholin; Fp. 135 o C. Example 6: A mixture from 1,9 parts of 4 [Dimethylamino) - phenolhydrochIorid, 4.2 parts of cis-2 (2,4-Dichlorphonyl) - 2 (IH-imidazol-l-ylmethy]) - 1,3-dioxolan-4-y] methylmethansulfonat, 4 parts of Ka] iumcarbonat and 80 parts of 4-Methyl-2-pentanon is agitated RST to 18 h under return flow. The reaction mixture is cooled down, shifted with water and twice with 1,1 ' - Oxyblsäthan extracts. The united organic excerpts are washed, dried, filtered off and evaporated with water. The received connection is transferred in a mixture from 2-Propanon and 2.2 ' - Oxybispropan into entspreIS the chende oxalate. The salt is filtered off and recrystallized from ethanol. Yield of 2.4 parts (37% d.Th.) of cis-4 [2 (2,4-Dichlorpheny]) - 2 (1H-imidazol-l-ylmethyl) - l, 3 - - dioxolan-4-ylmethoxy LN, N e-dimethylphenylaminoxal athydrat; Fp. I12,5 °C. Example 7: A mixture from 1,8 parts of n (4-Hydroxyphenyl) - propane amide, 4,2Teilen cis-2 (2,4-Dichlorphenyl) - 2 (1H-imidazo] - l-y] methyl) - l, 3-dioxo] an-4-y] methylmethansulfonat, 2 parts potassium carbonate and 67.5 parts of N, N-dimethylformamide is agitated 16 to 18 h at a temperature of 100°C under return flow. The Reaktionsgemlsch is then cooled down, poured in water and extracted twice with benzene. The united benzene excerpts are washed, dried, filtered and evaporated with water. The arrears become in a mixture from 4-Methyl-2-pentanon and 2.2 ' - Oxybispropan into the appropriate oxalate transfers. The salt is filtered off and recrystallized from 2-Propano]. The received connection is filtered off and 2 days at a temperature of 80°C is dried. Yield of 2.3 parts (37 d.Th.] Cis n {4 [2 (2,4-Dichlorphenyl) - 2 (IH-imidazol-l-ylmothyl) - -1,3-dioxolan-4-y] methoxy] - phenyl} - propanamidoxalat-2-propano] RK; Pp. 116,9°C. Example 8: A mixture from 1,7 parts of n (4-Hydroxyphenyl) - acetamid, 4.2 parts of cis-2 (2,4-Dichlorpheny]) - -2 (IH-imidazol-l-ylmethyl) - 1,3-dioxol an-4-ylmethylmethansulfonat, 2 parts potassium carbonate and 68 parts of N, N-dimethylformamide is agitated 16 to 18 h at a temperature of 100°C. The reaction mixture is cooled down, poured in water and ert twice with Trich] ormethan extrah. The united chloroform excerpts are washed, dried, filtered and evaporated twice with water. The arrears are digested in a mixture from 4-Methy] - 2-pentanon and 2.2 ' - Oxybispropan. The received connection is filtered off and recrystallized from 4-Methy] - 2-pentanon. Yield of 2.8 parts (61% d.Th.] Cis n {4 - [2 (2,4-Dichlorpheny]) - 2 (IH-imidazol-l-ylmethyl) - 0-l, 3-dioxolan-4-ylmethoxy] - pheny]} - acetamid; Fp. 180,5°C. A mixture from 8,9 parts of a {4 - [2 (2,4-Dichlorphenyl) - 2 (IH-imidazol-l-ylmethyl) - l, 3 - - dioxolan-4-ylmethoxy] - phenyl} - acetamid, 1.5 parts potassium hydroxide and 80 parts l-butanol 16 to 18 h under Rfickfluß one agitates. The reaction mixture is then evaporated, and that I ückstand is shifted with water. The precipitation is filtered off and recrystallized from methyl benzene. Yield of 6.6 parts (82% d.Th.) of eis-4 [2 (2,4-Dichlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - l.3 - dioxo] an-4-ylmethoxy] - pheny] amine; Fp. 164,4°C. Example 9: A mixture from 0,8 parts of Isothiocyanatomethan, 4.2 parts of eis-4 [2 (2,4-Dichlorphenyl) - -2 (IH-imidazol-l-ylmethyl) - l, 3-dioxolan-4-y] methoxy] - pheny] amine and 100 parts of 1,4-Dioxan are agitated h under Bfickfluß. The solvent is then abdestilliert, and the arrears are isiert from 4-Methyl-2-pentanon umkrista]]. The received connection is filtered off and umkristaHisiert from acetonitrile. Yield of 2.7 parts (53% d.Th.) of a {4 - [2 (2,4-Dichlorpheny]) - 2 (iH-imidazo] - 1-y] methyl) - -1,3-dioxo] an-4-y] methoxy] - pheny] IN '- methy] thiourea; Fp. 130.7 C. Example 10: Gemäht example 9, however under employment of of an equivalent quantity of Isothiocyanatoäthan, S is received a {to 4 - [2 (2,4-Dieh] orphenyl) - 2 (IH-imidazol-l-y] methy]) - 1,3-dioxol an-4-ylmethoxy] - phenyl) - - N' äthy] thiourea; Fp. 140,4°C. Example 11: A solution of 4,2 parts of cis-4 [2 (2,4-Dich] orpheny]) - 2 [IH-imidazo] - l-y] methyl) - l, 3-dioxo] an-4-ylmethoxy] - phenylamin in I0 parts of acetic acid becomes under agitating with 20 parts water verI0 sets. After a further addition of a solution of 1 part potassium isocyanate in 20 parts water the entire mixture 1 h is agitated at ambient temperature. The mixture is then shifted with 200 parts water and neutralized with Ka] iumearbonat. The reaction product is extracted with Trich] ormethan. The TrichIormethanextrakt is dried, filtered and evaporated. The arrears are recrystallized from 4-Methy] - 2-pentanon. The received connection is filtered off and isiert again from the same solvent umkrista]]. Yield of 2.9 parts (62% d.Th.) of cis n {4 - [2 (2,4-Dich] orpheny]) - 2 (1B-imidazel-l-ylmethyl) - -1,3-dioxo] an-4-y] methoxy] - pheny]} - urea; Fp. 155,1°C. Example 12: Are mixture from 1 part of Isocyanatomethan, 4.2 parts of cis-4 [2 (2,4-Dich] orpheny]) - 2 (1H-imidazo] - l-y] methy]) - l, 3-dioxo] an-4-ylmethoxy] - pheny] amine and 75 parts of 1,4-Dioxan 16 to 18 h at ambient temperature one agitates. The reaction mixture is evaporated, and the arrears are lislert from 4-Methyl-2-pentanon umkrista]. The received connection is filtered off and dried. Yield of 3.5 parts (73% d.Th.) of a {4 - [2 [2,4-Dich] orphenyl) - 2 (IH-imidazol-I-y] methyl) - -1,3-dioxo] an-4-y] methoxy] - phenyl) - Ne-methylharnstoff; Fp. 169°C. Example 13: In accordance with example 12, however under employment of an equivalent quantity of Isocyanatoäthan and IsoeyanatobenzoI, the following connections are received: Cis n {4 - [2 (2,4-Dichlorpheny]) - 2 (1H-imidazol-l-ylmethyl) - 1,3-dioxolan - ylmethoxy] - phenyl} - N' ethyl urea; Fp. 154,3°C. Cis n {4 - [2 (2,4-Dichlorpheny]] - 2 (IH-imida zol l y] methy]) - i, 3-dioxol an-4-ylmethoxy] - phenyl} - - N' phenylharnstoffnitrat; Fp. 127,3°C. Example 14: A mixture from 40 parts of formic acid and 4.2 parts of eis-4 [2 (2,4-DJch] orphenyl) - 2 (l l - imidazo] - l-y] methy]) - l, 3-dioxolan-4-y] methoxy] - pheny] amine is agitated 48 h under Rückf] uß. The reaction mixture is cooled down and evaporated. The arrears are solved in water and neutralized with Natrlumhydrogencarbonat. The product is extracted twice with Trieh] ormethan. The united Trieh] ormethanextrakte is dried, filtered and evaporated. The arrears are llsiert from a mixture from 4-Methy] - 2-pentanon and 2.2 ' - Oxybisprepan umkrista]. Yield of 3.8 parts (85% d.Th.) of cis n {4 - [2 (2,4-Dich] orpheny]) - 2 (iH-imidazo] - l-ylmethy]) - &0-l, 3-dioxo] an-4-ylmethoxy] - phenyl] - form amide; Fp. 132,6QC. Example 15: A mixture from 1,8 parts of Kohlensäurech] oridmethylester, 4.2 parts of cis-4 [2 (2,4-Dichlorpheny]) - 2 (IH-imidazo] - l-y] methyl) - l, 3-dioxo] an-4-y] methoxy] - pheny] amine, 2 parts of Ka] iumaarbonat and 75 parts of 1,4-Dioxan is agitated I h under Rückf] uß. The reaction mixture is poured cooled down 5 and in water. By course abe ven 2.2 ' - Oxybispropan fails the Beaktionsprodukt. It is filtered off and in a mixture from 2-Propanon and 2.2 ' - Oxybispropan into the appropriate nitrate transfers. The salt is triert abfi] and recrystallized from Acetenitril. Yield of 3.4 parts (63% d.Th.) cis methyl {4 [2 (2,4-dich] orphenyl) - 2 (1H-imidazo] - l-y] methy] - -1,3-dioxol an-4-yl methoxy] - pheny]} - carbamatnitrat; Fp. 157.6 QC. Example 16: A mixture from 1,7 parts of Dichloracetylchlorid, 4.2 parts of cis-4 [2 (2,4-Dichlorphenyl) - 2 - - (1H-imidazol-l-y] methyl) - l, 3-dioxolan-4-y] methoxy] - phenylamin, 2 parts potassium carbonate and 100 parts of 1,4-Dioxan 4 h under Rückf] uß one agitates. The reaction mixture is then cooled down, poured in water and extracted on twice with l, l' Oxybisätl. The united organic excerpts are getrooknet, filtered and evaporated. The arrears are isiert from 4-Methy] - 2-pentanon umkrista]]. The received connection is triert and dried abfi]. Yield of 3.9 parts (73% d.Th.) of cis-2,2-Dich] or-n {4 - [2 (2,4-dich] orpheny]) - 2 (IH-imidazo] - - la-y] methyl) - i, 3-dioxol an-4-y] methoxy] - pheny]} - acetamid; Fp. 165,6°C. Example 17 “a solution of 8,4 parts of cis-4 [2 (2,4-Dichlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - l, 3-dioxolan-4-ylmethoxy], cooled in an ice bath - phenyiamin in 75 parts Pyridin and 112 parts of Trich] ormethan are shifted drop by drop with 3,5 parts of Koh] ensäurechloridpheny] esters. After completion of the addition agitating 3 h is continued at ambient temperature. Then the Beaktionsgemisch is poured in water and extracted twice with Trich] ormethan. The united chloroform excerpts are getrooknet, filtered and evaporated. The arrears become with a mixture from l, l' Oxybisäthan and 2.2 ' - Oxybispropan digests. The received product is filtered off and recrystallized from 4-Methyl-2-pentanon. Yield of 8.6 parts cis Phenyl egg 4 - [2 (2,4-dichlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - I, 3-dioxol on -4-ylmethoxy] - phenyl} - carbamat; Fp. 170,6°C. Example 18: A solution cooled in an ice bath by 13 parts carbon disulfide and 2.1 parts of N, N' - Methantetray] to (cyc] ohexanamin) in 15 parts Pyridin becomes at a temperature of - i0 to 20-5°C drop by drop under agitating into a solution of 4,2 parts of cis-4 [2 (2,4-Dich] orphenyl) - 2 (IH - imidazol l ylmethy]) - l, 3-dioxolan-4-ylmethoxy I - phenylamin in 25 parts Pyridin given. After completion of the addition the mixture 3 h at the temperature mentioned and a further hour is agitated at ambient temperature. The Beaktionsgemisch is then evaporated. The arrears are solved in 20 parts of acetic acid. The solution is shifted under agitating with 50 parts water. The formed precipitation is filtered off, and the filtrate is neutralized with potassium carbonate. The received product is extracted with l, l' Oxyhisäthan. The organic excerpt is filtered and evaporated GET skirt emergency. The arrears are cleaned by Säulenchromatographie at silicagel using Trich] ormethan as Elutionsmittel. The pure parliamentary groups are collected and the Elutionsmittel is abdestilliert. The arrears become from a mixture from 4-Methyl-230-pentanon and 2.2 ' - Oxybispropan recrystallizes. The received connection is filtered off and dried. Yield of 3.2 parts (69 d.Th.) of cis l [2 (2,4-Dichlorphenyl) - 4 (4-isothiocyanatophenoxymethyl) - - l, 3-dioxo] an-2-ylmethyl] - IH-imidazol; Fp. 136°C. Example 19: A mixture from 90 parts ammonium hydroxide, 5 parts of cis l [2 (2,4-Dichlorphenyl) - 4 (4-isothiocyanatophenoxymethy]) - l, 3-dioxo] an-2-y] methyl] - 1H-imidazol and 200 parts methanol are agitated 3 h at ambient temperature. The reaction mixture is poured in water and extracted then with chloroform. The Trich] ormethanextrakt is washed, filtered and evaporated with water. The arrears become by Säulenchromatographie at silicagel using a mixture from chloroform and methanol (98 “. 2 VOL. - Parts) as Elutionsmittel cleaned. The pure parliamentary groups are collected, and that Elutionsmitte] is abdestilliert. The arrears are recrystallized from 4-Methyl-2-pontanon. Yield of 2.8 parts (54% d.Th.) of cis n (4 - [2 (2,4-Dichlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - -1,3-dioxo] an-4-yl methoxy] - phenyl} - thiourea; Fp. 190,4°C. Example 20: A) A mixture from 33,8 parts of 4 (1-Piperaziny]) - pheno] dihydrobremid, 11.2 parts acetic anhydrid, 42 parts potassium carbonate and 300 parts of 1,4-Dioxan 3 days under return flow one agitates. The Beaktionsgemisch is filtered, and the filtrate is evaporated. The firm arrears are agitated in water and shifted then with Natriumhydrogencarbonat. After 30minütigem agitating is filtered off the formed precipitation and solved in diluted hydrochloric acid. The solution is extracted with chloroform. The aqueous phase is separated and neutralized with ammonium hydroxide. The formed connection is filtered off and recrystallized from ethanol. Yield of 5.7 parts of l-Acety] - 4 (4-hydroxyphenyl) - piperazin; Fp. 181,3°C. B) A mixture from 2,4 parts of the connection received in accordance with A), 0.4 parts of Natriumhydrlddlspersion (76%), 75 parts of Dimethy] sulfoxyd and 22.5 parts of Benzo] is agitated i h at a temperature of 4fl°C, then with 4,2 parts of cis-2 [2,4-Dich] orphenyl) - 2 (iH - imidazol l ylmethyl) - l, 3-dioxolan-4-ylmethylmethansulfonat it shifts on which agitating 16 to 18 h at a temperature of 1O0oC is continued. The Reaktionsgemlsch is cooled down and diluted with water. The received product becomes with 1,1 ' - Oxybisäthan extracts. The organic excerpt is dried, filtered and evaporated. The arrears are recrystallized from 4-Methyl-2-pentanon. The received connection is filtered and dried abI0. Yield of 3.2 parts (59% d.Th.) of cis l Acety] - 4 {4 [4 (2,4-dich] orphenyl) - 2 (IH-imidazo] - l-y] methy]) - l, 3-dioxol an-4-ylmethoxy] - phenyl} - piperazin; Fp. 146°C. Example 21: A mixture from 21 parts of the connection received in accordance with example 20, 10 parts potassium hydroxide and 200 parts of 1-Butanol is agitated 16 to 18 h under return flow. The reaction mixture is cooled down and shifted with benzene. The entire mixture is washed with water, filtered GET skirt emergency and. The Fi] stepped is evaporated. The arrears are lisiert from 4-Methyl-2-pentanon umkrista], the received connection is filtered off and dried. Yield of 13.9 parts (71% d.Th.) of cis-1 [4 - [2 (2,4-Dichlorpheny]) - 2 (1H-imidazol-l-ylmethyl) - -1,3-dioxol an-4-ylmethoxy] - pheny]} - piperazin; Fp. 170,7 °C. Example 22: A mixture from 0,9 parts of Isothiocyanatomethan, 4.9 parts of the connection received in accordance with example 21 and 100 parts of 1,4-Dioxan is agitated 16 to 18 h at ambient temperature. The formed precipitation is filtered off and recrystallized from 1,4-Dioxan. The Kristal] isat is filtered off and recrystallized again from 4-Methyl-2-pentanon. Yield of 2.7 parts (47% d.Th.) of cis-4 {4 - [2 (2,4-Dichlorphenyl) - 2 (IH-imidazol-l-ylmethy]) - -1,3-dioxolan-4-ylmethoxy] - phenyl] - N-methyl-l-piperazincarbothioamidmonohydrat: Fp. 138,2°C. Example 23: A mixture from 1 part of Isethiccyanatoäthan, 4.9 parts of the connection received in accordance with example 21 and 130 parts of Dichlormethan is agitated 3 h at ambient temperature. The reaction mixture is evaporated, and the arrears become with a mixture from 4-blethyl-2-pentanon and 2.2 ' - Oxybispropan digests. The received product is filtered off and visiert from 4-I ethFI-2-pentanon umkristal. Yield of 5.2 parts (89% d.Th.) of cis-4 {4 [2 (2,4-Dichlorphenyl} - 2 (1H-imidazol-l-y] methyl) - l, 3 - - dioxol an-4-Flmethoxy] - phenyl} - Ne-ethyl-l-piperazincarbothioamidhemihydrat; Fp. 187,9°C. Example 24: A mixture from 0,7 parts of Isocyanatomethan, 4.9 parts of the connection received in accordance with example 21 and 100 parts of 1,4-Dioxan is agitated 16 to 18 h at ambient temperature. After the Abdestillieren of the solvent the arrears become by Säulenchromatographie at silicagel using a mixture from chloroform and methanol (98: 2 VOL. - Parts) as Elutionsmittel cleaned. The pure parliamentary groups are collected, and that blood ion means is abdestilliert. The arrears are recrystallized from 4-Methyl-2-pentanon. The received connection is filtered off and dried. Yield of 3.7 parts (66% d.Th.) of cis-4 {4 - [2 (2,4-Dichlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - -1,3-dioxolan-4-ylmethoxy] - phenyl} - N-methyl-l-piperazincarboxamidmonchydrat; Fp. 120,6°C. Example 25 " quantities of Isocyanatoäthan equivalent in accordance with example 24, however under employment and/or Isocyanatopropan, is received the following connections: eis-4 {4 - [2 (2,4-Dichlorphenyl) - 2 (1H-imidazol - ylmethyl) - 1,3-dioxol an-4-ylmethoxy] - phenyl] - - N-ethyl-l-piperazincarboxamidmonohydrat; Fp. 121,2°C. eis-4 {4 - [2 (2,4-Dichlorphenyl) - 2 (1H-imidazol-l-ylmethy]) - 1,3-dioxol an-4-y] methoxy] - pheny]} - - N-propyl-l-piperazincarboxamiddihydrat; Fp. 111,1°C. Example 26: A mixture from 1 part of I aliumisoayanat, 4.9 parts of the connection received in accordance with example 21, 0.6 parts of acetic acid, 50 parts water and 50 parts of 1,4-Dioxan is agitated 16 to 18 h at tree temperature. After the Abdesti]] Jeren the solution center] of the s becomes the arrears by Säu] enehromatographie at gravel] ge] using a mixture from Trich] ormethan and Methano] (98: 2 VE]. - Tei] e) as E] utionsmitte] cleaned. The pure parliamentary groups are collected, and the E] utionsmitte] abdestil] is iert. The arrears become from 4-Methy] - 2-peutanon umkrista]] isiert. The received connection is triert and dried abfi]. Yield of 2 parts (38% d.Th.) of cis-4 {4 [2 (2,4-Dich] erpheny]) - 2 (iH-imidazo] - l-y] methy]) - l, 3 - - dioxo] an-4-y] methoxy] - pheny]} - l-piperazincarboxamid; Fp. 189,8°0. Example 27: I0 a mixture from 1,2 parts of Koh] ensäurech] oridmethylester, 4.9 parts of the connection received in accordance with example 21, 2 parts of Natriumhydregencarbonat, 100 parts of 1,4-Dioxan and 50 parts water is agitated 16 to 18 h at ambient temperature. After the addition ven water to the reaction mixture the formed precipitation one filters off and from 4-Methy] - 2-pentanon one recrystallizes. Yield of 3.8 parts (68% d.Th.) of cis-Methyl-4 {4 - [2 (2,4-dichlorpheny]) - 2 (IH-imidazoI-l-y] methy]) - i, 3-dioxol an-4-y] methoxy] - pheny]} - l-piperazincarboxy] RKs; Fp. 137,5 °C. Example 98: In accordance with example 27 ester with received the connection in accordance with Beispie] 21 becomes oisthy] - 4 - {4 - [2 (2,4-dichIorpheny]) - 2 (IH-imidazol-l-ylmethyl) - by shifting of Koh] ensäurech] oridäthy] - i, 3-dioxo] an-4-y] methoxy] - phenyl} - l-piperazincarboxy] RK hergestel] t; Fp. 112,2°C. Example 29: A mixture from 60 parts of formic acid and 4.8 parts of the connection received in accordance with example 21 is agitated 16 to 18 h under return flow. The reaction mixture is cooled down, shifted with water and adjusted with a 50%igen sodium hydroxide solution alkalinely. The product is extracted with Trich] ormethan. The chloroform excerpt is dried, filtered and sing-steams. The arrears are recrystallized from 4-Methyl-2-pentanon. Yield of 5.3 parts (100% d.Th.) of eis-4 {4 [2 (2,4-Dichlerphenyl) - 2 (iH-imidazc] - l-y] methy]) - - I, 3-dioxolan-4-y] methoxy] - pheny] l - la-piperazincarboxaldehyd; Fp. 153,4°C. Example 30: A mixture from 2 parts of Dimethy] carbaminsäurechlorid, 4.9 parts dör in accordance with example 21 received connection, 4 parts of Ka] iumearbonat, 130 parts of Dieh] ormethan and 20 parts water is agitated 3 h at ambient temperature. The reaction mixture is then diluted with water and agitated 16 to 18 h at ambient temperature. You] ormethan layer one separates, and the solvent is evaporated. The arrears are digested with a mixture from 4-Methy] - 2-pentanon and 2.2 ' - Oxybispropan. The received connection is filtered off and isiert from 4-Methyl-235-pentanon umkrista. Yield of 4.8 parts (86% d.Th.) of eis-4 {4 - [2 (2,4-Dichlorpheny]) - 2 (LH-imidazol-l-yimethyl) - - I, 3-dioxolan-4-ylmethoxy] - phenyl} - N, N-dimethy - l-piperazincarboxamid; Fp. 143,8°C. Example 31: A mixture from 1,5 parts of Benzoy] CH] orid, 4.9 parts of the connection received in accordance with example 21, 3 parts of Ka] iumcarbonat, 130 parts you] ormethan and 20 parts water is agitated 1 h at tree temperature. After the addition of water the mixture further 2 h is agitated at tree temperature. The organic phase is then separated, dried, filtered and evaporated. The arrears are transferred in 2-Propanon into the appropriate oxalate. The salt is filtered off and from a mixture from Äthano] and 2.2 ' - Oxybispropan umkristaliisiert. Yield of 5.9 parts (80% d.Th.) of cis-la-Benzoyl-4 {4 - [2 (2,4-dich] orpheny]) - 2 (iH-imidazo] - l - y] methyl) - i, 3-dioxo] an-4-yl methoxy] - pheny]} - piperazinoxa] RK (2: 3) - hemihydrat; Fp. 132,9 °C. Example 32: in mixture from 1,5 parts of prop. ion ureanhydrld, 4.9 parts of the connection received in accordance with example 21, 2 parts potassium carbonate and 130 parts you] ormethan at tree temperature only 2 h and after addition by 20 parts water is agitated a further hour. After the separation of the layers the organic layer is evaporated. The arrears are isiert from 4-Methyl-2-pentanon umkrist l]. The received connection is filtered off, treated with potassium carbonate and isiert from 4-Metby] - 2-pentanon umkrlsta]]. Yield of 3.6 parts (66% d.Th.} hurrying {4 [2 (2,4-Dichlorphenyl) - 2 (IH-imidazol-l-ylmethy]) - -1,3-dioxolan-4-ylmethoxy] - phenyl} - 4 (1-oxopropy]) - piperazln; Fp. 122,7°C. Example 33: A mixture from I0 parts of Schwefe] keh] enstoff, 19.6 parts of the connection received in accordance with example 21, 2.4 parts sodium hydroxide, 80 parts methanol and 100 parts water is agitated 3 h at ambient temperature. After the addition of 7,5 parts dimethyl sulfate is continued agitating 1 h at ambient temperature. The Reaktionsgemiseh is then shifted with water and extracted with you] ormethan. The Dichlormethanextrakt is dried, filtered and evaporated. The arrears are digested in 4-1 ethyl-2-pentanon. The received connection is triert abfi] and recrystallized from methanol. Yield of 23.1 parts {100% d.Th.) cis-Methyl-4 {4 - [2 (2,4-dichlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - 1,3-dioxol an-4-yl methoxy] - phenyl} -1-piperazincarbodithieat; Fp. 132,9 °C. Example 34: A mixture from 1,7 parts of Kohlensäurech] oridphenylester, 4.9 parts of the connection received in accordance with example 21, 2 parts potassium carbonate and 130 parts of Dichlormethan is agitated 2 h at ambient temperature and after the addition by 20 parts water a further hour at ambient temperature. The organic phase is then separated and evaporated from the reaction mixture. The arrears are digested in a mixture from 4-Methy] - 2-pentanon and 2.2 ' - Oxybispropan. The received connection is filtered off and isiert from 4-Methyl-2-pentanon umkristal]. Yield of 5.3 parts (87% d.Th.) of cis-Phenyl-4-E 4 - [2 (2,4-dichlorphenyl) - 2 (IH-imidazo] - l-ylmethyl) - 1,3-dioxol an-4-ylmethoxy] - pheny]} -1-piperazincarboxy] RK; Fp. 159,5°C. Example 35: In accordance with example 20 B), however under employment of equivalent quantities of the appropriate parent compounds, is manufactured the following connection: trans-l-Acetyl-4 {4 - [2 {2,4-dichl orphenyl) - 2 (1H-imidazol-l-ylmethyl) - 1,3-dioxol an-4-ylmethoxy] - - phenyl l-piperazin-dihydrochleriddihydrat; Fp. 175,9°C. Example 36: A mixture from 174 parts of 2-Brom-la (3-ch] orphenyl) - äthanon, 81 parts of 1,2,3-Propantriol, 7.4 parts of 4-Methylbenzclsulfensäure, 94 parts of 1-Butanol and 528 parts benzene under Verwcndung of a water trap 20 h under Rückf] uß one agitates. The reaction mixture is then poured onto a diluted Natriumhydrexydlösung, and the formed layers are separated. The aqueous phase is extracted twice with methyl benzene. The united organic phases are washed, dried, filtered and evaporated twice with water. Yield of 238 parts of cis+trans-2 (Brommethyl) - 2 (3-chlorphenyl) - l, 3-diexolan-4-methanol. 238 parts of the received connection are solved in a mixture from 144 parts of Pyridin and 1135 parts of Trich ormethan. After the cooling of the solution on a temperature for instance 5°C ven it at a temperature of under 10°C drop by drop with 149 parts of Benzoylchlorid are shifted. After Beendignng of the addition agitating 2 h is continued at ambient temperature. The reaction mixture is then poured in water, and the formed layers are separated. The aqueous layer is extracted twice with chloroform. The united excerpts are washed, dried, filtered and evaporated twice with water. The arrears w RD some hours in witches agitated. The precipitated precipitation is filtered off and dried at air. Yield of 126 parts cis+trans [2 (Brommethy]) - 2 (3-chlorpheny]) - l, 3-dioxolan-4-ylmethyl] - benzoat. A mixture from 6 parts of iH-Imidazol and 68.5 parts of a 30%igen Natriummethano] atlösung is agitated 15 min under return flow. After the addition of 90 parts of N, N-dimethylformamide is iert bfs to an internal Tempertur of 130°C methanol abdesti]]. Then becomes drop by drop a LSsung ven 102.5 parts cis+trans [2 (Brommethyl) - 2 (3-chlorphenyl) - l, 3-dioxolan-4-ylmethyl] - N-dimethylformamide benzoat admitted in 225 parts of N. After completion of the addition the mixture 3 h under Bückf is agitated] uß, cooled down then and shifted with water. The received product is extracted three times with 4-Methyl-2-pentanon. The united excerpts are washed, dried, filtered and evaporated twice with water. Yield of 43 parts cis+trans [2 (3-Ghlorphenyl) - 2 (IH-imidazol-l-ylmethyl) - 1,3-dioxolan-4-ylmethyl] - benzoat. A mixture from 45 parts of the received connection, 36 parts of a 50%igen Natrlumhydroxydlösung, 600 parts of 1,4-Dioxan and 200 parts water is agitated i h under return flow. The s reaction mixture is cooled down and poured in water. According to the addition of chloroform the formed layers are separated. The organic layer is washed, dried, filtered and evaporated with water. The arrears are transferred in a mixture from 2-Propanon and 2-Propanol into the appropriate hydrochloride. After 2stündigcm agitating in an ice bath is filtered off and dried the salt. Yield of 14 parts of cis+trans-2 (3-Chlorphenyl) - 2 (IH-imidazol-l-ylmethyl) - l, 3-dioxolan-4-meth - nolmonohydrochlorid; Fp. 198,3°C. A mixture from 68 parts of cis+trans-2 (3-Chlorphenyl) - 2 (1H-imidazo] - l-ylmethyl) - l, 3-dioxolan -4-methanol and 570 parts of Pyridin is cooled down on a temperature of 0°C. After dern removing the ice bath the Gemach drop by drop with 26,3 parts of Methansulfony] CH] orid shifts IS (exotherms reaction under temperature rise on 20°C}. After completion of the addition the mixture 3 h is agitated at ambient temperature and poured then in water. The received product is extracted with chloroform. The Trich] ormethanextrakt is dried, filtered and evaporated. The arrears are transferred in a mixture from 2-Propanon and 2-Propanol into the appropriate hydrochloride. The salt is filtered off and recrystallized from 2-Propanc]. Yield of 32 parts [2 (3-Ch] orphenyl) - 2 (IH-imidazol-l-ylmethyl) - l, 3-dioxolan-4-ylmethyl] - methansu] fonatmonohydrochlorid. Example 37: A mixture from 1,6 parts of IH-1,2,4-Triazo], 54 parts of N, N-Dimethy] form amide and 45 parts benzene wlrd 2 h under return flow agitated. After the cooling 0.78 parts of Natriumhydriddisper2s are admitted sion (78%), and the whole mixture is agitated 3Q min at ambient temperature. After the addition of 8,9 parts ci -2 (Brommethy]) - 2 (2.4-dichlorphenyl) - l.3-dioxolan-4-ylmethylbenzoat is continued agitating the mixture 16 to 18 h at a temperature of 150°C. The reaction product is then cooled down, poured in water and extracted three times with benzene. The united benzene excerpts are washed, dried, filtered and evaporated twice with water. Yield of 8.5 parts of ice (2 (2,4-Dichlorphenyl) - 2 (1H-l, 2,4-triazol-l-ylmethy]) - l, 3-dioxolan-4 - ylmethy]] - benzoat. A mixture from 289 parts of the received connection, 200 parts of 50%iger sodium hydroxide solution, 1500 parts of 1,4-Dioxan and 300 parts water is agitated 2 h under Rückf] uß. The reaction mixture is cooled down, poured in water and extracted with Dichlormethan. The Dichlormethanextrakt is washed, dried, filtered and evaporated with water. The arrears become by Säulenchromatographie at silicagel using a mixture from chloroform and Methano] (95; 5 VOL. - Parts) as E] utionsmittel cleaned. The first parliamentary group is collected, and that Elutionsmittel is abdestilliert. Yield of 89 parts of cis-2 (2,4-Dichlorpheny]) - 2 (IH - I, 2,4-txiazol-l-ylmethy]) - 1,3-dioxol an-4 - methanol; Fp. 138; 2°G. A mixture from 30,6 parts of the received connection and 75 parts of Pyridin is shifted at ambient temperature under agitating drop by drop with 17,2 parts methane sulphonyl chloride. After Beendlgung of the addition agitating 16 to 18 h at ambient temperature is continued. The reaction mixture is poured in ice water and extracted twice with Dichlormethan. United you] ormethanextrakte twice with diluted hydrochloric acid and then twice with water are washed, dried, filtered and evaporated. The arrears become by Säulenchromatographie at silicagel using a mixture from Trichl0rmethan and methanol (95: 5 VOL. - One collects parts) as Elutionsmittel cleaned, the first parliamentary group, and the E] utionsmitte] abdesti] is liert. Yield of 21 parts of ice [2 (2,4-Dichlorpheny]) - 2 (IH-1,2,4-triazo] - l-ylmethy]) - l, 3-dioxolan-4 - y] methyl] - methansulfonat; Fp. 98°C. Example 38: A mixture from 13,2 parts of 1 (4-Methoxyphenyl) - piperazindihydrochlorid, 5.1 parts of 1-Butanal, 9 parts Natriumacetat and 80 parts methanol at ambient temperature and with ambient pressure using 1 part of Pa]] adium up charcoal is converted as catalyst with hydrogen. After the computed quantity hydrogen was used, the catalyst is filtered off. The Fi] stepped is evaporated. The arrears are shifted with water and the product ausgefä]] t. It is filtered off, washed with water and transferred in a mixture from Äthano] and 2-Propano] into the appropriate Hydroch] orid. By addition of 2,2 ' - Oxybispropan becomes the salt ausgefä]] t. It is trlert abfi] and recrystallized from a mixture from ethanol and 2.2 ' - Oxybispropan. Yield of 13.1 parts (81% d.Th. } 1-Butyl-4 (4-methoxyphenyl) - piper azindi hydroch] orid; YP. 214,2°C. Example 39: In accordance with example 38, however quantities of the appropriate aldehydes or Ketone equivalent under employment, are manufactured the following connections: 1 (4-Methoxypheny]) - 4-propyl piperazindihydrochlori D; Fp. 214.7 o C. 1 (4-Methoxypheny]) - 4 (1-methylpropyl) - piperazindihydrochlorid; Fp. 223,5°C. 1 (4-Methoxyphenyl} - 4 (2-methylpropyl} - piperazindihydroch] orid; Fp. 220,3°C. 1 (4-Methoxyphenyl} - 4 (1-methyIäthyl) - piperazindihydrochlorid; Fp. 230, I°C. 1 (4-Methoxyphenyl) - 4 (phenylmethyl) - piperazindihydrochlorid; Fp. 234°C. Example 40: A mixture from 12,5 parts of 1-Buty] - 4 (4-methoxyphenyl] - piperazindihydrochl orid and 150 parts of a 48%igen solution of Bromwasserstoff in glacial acetic acid is agitated 16 to 18 h under Rückf] uß. The reaction mixture is evaporated, and the arrears are digested with 2-Propanon. The received connection is filtered off and recrystallized from water. Yield of 13.1 parts (81% d.Th.) of 4 (4-Butyl-l-piperazinyl) - phenol mono hydraulic bromide; Fp. 281,9°C. Example 41: In accordance with example 40, however under employment of an equivalent quantity of the appropriate (4-Methoxyphenyl] - piperazins, the following connections are manufactured: 4 (4-Propy] - l-piperaziny!)- phenolsesquihydrobromid; Fp. 241,8°C. 4- [4 (1-Methy] propyl} - l-piperazinyl] - pheno] dihydrobromid; Fp. 280,4 °C. 4- [4 (2-Methylpropyl} - l-piperazinyl] - phenol; Fp. 179,4°C. 4- [4 (1-Methyl ethyl) - l-piperaziny]] - phenol; Fp. 247,4°C. 4- [4 (Phenylmethyl} - l-piperazinyl] - pheno] mono hydraulic bromide; Fp. 264.7°C. Example 42: A mixture from 17 parts of 4 (1-Piperazinyl} - pheno] dihydrobromid, 7 parts of Kohlensäurech] oridäthylester, 21 parts potassium carbonate and 250 parts of 1,4-Dioxan is agitated 48 h under return flow. The reaction mixture is hot filtered off, and the Fi] stepped one evaporates. The firm arrears are solved in diluted hydrochloric acid. The solution is alkalinely stopped with ammonium hydroxide. 49 the received connection one triert and one dries abfi]. Yield of 3.5 parts of Äthy] - 4 (4-hydroxypheny]) - l-piperazincarbcxylat; Fp. 168,8°C. Example 43: In accordance with example 42, however under employment of an equivalent quantity of 2oder 3 (1-Piperazinyl} - phenoldihydrobromid, the following connections become gesture of] lt: Äthyl-4 (2-hydroxypheny]} - l-piperazincarboxy] RK; Fp. 141.8 C. Äthy] - 4 (3-hydroxypheny]) - l-piperazincarboxy] RK; BP. 123,4°C. Example 44: A solution of 80 parts of 3 (1-Piperaziny]) - phenoldihydrobromid in 360 parts water and 180 parts chloroform are shifted by portion at a temperature of 1O°C under agitating with 42 parts Natriumhydrogencarbonat. Subsequently, at the same temperature during 15 min drop by drop 26 parts acetic anhydrid are admitted. After completion of the addition agitating 3 h is continued at ambient temperature. Ausgefäl] the Te product is filtered off, washed with water and recrystallized from 2-Propano]. Yield of 37 parts {70% d.Th.) l-Acety] - 4 (3-hydroxypheny]) - piperazin; Fp. 186,1°C. Example 45: A mixture from 12,9 parts of 4 (l-Piperazinyl) - phenoldihydrobromid, 40 parts of Äthanel and parts water under agitating with 12,6 parts Natriumhydrogencarbonat is shifted. Subsequently, at a temperature of 0ec drop by drop 6.4 parts methane sulphonyl chloride are admitted. After completion of the addition agitating 16 to 18 b is continued. The precipitated product is filtered off and taken up to water. After a] kaliseh Einste] len with a NaLriumhydroxydlösung the product 30 min at ambient temperature are agitated and then over Hyflo filtered. After dern acidifying the filtrate with acetic acid the precipitated product is abfiILriert and geLrocknet. I0 yield of 2.8 parts of l (4-Hydroxyphenyl) - 4 (meLhylsulfonyl) - piperazin; Fp. 204,9°C. Example 46: A solution of 3.6 parts of n (4-Hydroxyphenyl) - N-methylacetamid in 100 parts Dimethylsulfoxyd are admitted under agitating 0.7 parts of a sodium hydride dispersion (78%). Agitating is continued up to the Beendägung of the Sehäumens. After the addition of 8,4 parts of cis-2 (2.4 - - Dichlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - 1,3-dioxol an-4-ylmethylmethansul fonat is agitated the mixture 3 h at a temperature of 100°C, cooled down then and poured in water. The product is extracted with you] ormethan. The Dichlormethanextrakt is washed, dried, filtered and evaporated with diluted Natriumhydrcxydlösung. The arrears are transferred in 2-Propanol into the appropriate oxalate. The salt is filtered off and recrystallized from 2-Propanol. Yield of 9.2 parts of cis n {4 - [2 (2,4-Dichlorphenyl) - 2 ([H-imidazol-l-ylmethyl) - l, 3-däoxo] on -4-y] rnethoxy] - pheny]] - N-methy] acetamidoxalat (1: 1); Fp. 110°C. Example 47 " quantities of the appropriate parent compounds equivalent in accordance with example 4, however under employment, the following connections in form of the free base or after their treating with an appropriate acid in form of the appropriate salt are received; I CH acre 0> % I o acre 2,4-C12-Cs H s 2,4-C12-C6H 3 2,4-C12-CsH s 2,4-G] 2-Gs H 3 2,4-C12-C6H 3 2,4-G12-C6 H 3 2,4-C] 2C H 3 R CH CH (CH 3) - CH 2 - CH 3 CH2-CH (CH3) 2 base or salt 2 (COOH) 2nd C2 HsOH 3 HC]. HzO 3 HC]. H2 0 of isomer cis cis cis CH (CH3) 2 (CH 2) 3GH 3 CH z-CH2-CH CH z-C H s 3 HGI. GHs - CHOH-CH, 3 HC]. H20 2 I/2 (COOH) 2 3 HCI. H2 0 cis cis cis cis Fp. 136,7°C 193,6°C 179,8°C 192,8°O 178,5°C 171, i°C 212,8°C acre 3-CH 3 - C s H base or salt (E) - HOOC-GH= CH-COOH base (COOH) 2 of isomer cis cis Fp. 162,7°C 209°G 190,9°C example 48: In accordance with example 4, however quantities of the appropriate parent compounds equivalent under employment, are manufactured the following connections: cis-4 [2 (2,4-Dichlorpheny]) - 2 (IH-imidazol-l-ylmethy]) - I, 3-dioxol an-4-ylmethoxy] -2 - nitrophenylamin; Fp. 148,1°C. ci s-4 [2 - (2,4-Di chl orphenyl) - 2 (1H-imidazol-l-yl methyl) - i, 3-dioxol an-4-yl methoxy] - N-ethyl phenylamin; Fp. 143°G. Cis Äthy] - 4 - {2 - [2 (2,4-dichlorpheny]) - 2 (IH-imidazol-l-ylmethyl] - i, 3-dioxo] an-4-ylmethoxy] - pheI0 nyl} - 1-piperazincarboxylatdihydrochlorid; Fp. 195.4 G. Example 49: In accordance with example 3, however quantities of the appropriate parent compounds equivalent under employment, are manufactured the following connections: Äthy] - 4 - {4 - [2 (IH-imidazo] - l-y] methyl) - 2 (4-methoxypheny]) - I, 3-dioxo] an-4-ylmethoxy] - phenyl} - 15-1-piperazincarboxylat (E) - 2-succinat (2: 1); Fp. 159,9°G. l-Acetyl-4 {4 - [2 (IH-imidazol-l-ylmethyl) - 2 (4-methoxyphenyl) - l, 3-dioxo] an-4-ylmethoxy] - phenyll piperazin; Fp. 171,4°G. ci s-Äthy1-4 {3 - [2 - (2,4-di ehl orphenyl) - 2 - (1 rear one mi dazol l yl methyl) - 1,3-dioxol an-4-yl methoxy] - - pheny]} - l-piperazincarboxy] RK; Fp. II 9.5 degrees. cis-l-Acetyl-4 {3 - [2 (2,4-dichlorphenyl) - 2 (IH-imidazol-l-ylmethyl) - l, 3-dioxolan-4-ylmethoxy] - - pheny] l-piperazindihydrobromidmonohydrat; Fp. 206,5°C. Example 50: In accordance with example 7, however quantities of an appropriate n (Hydroxypheny), enter under employment äquiva] - acetamids, the following connections are manufactured: Cis n {2 - [2 (2,4-Dich] orpheny]} - 2 (iH-imidazol-l-ylmethyl) - I, 3-dioxolan-4-ylmethoxy] - phenyl] - - acetamidnitrat: Fp. 183,6°C. Cis n {3 - [2 (2,4-Dichlorpheny]} - 2 (1H-imidazol-l-ylmethyl) - I, 3-dioxolan-4-ylmethoxy] - phenyl} - - aeetamidnitrat; Fp. 171}, 5°G. Example 51: A mixture from 2,2 parts of n (5-Hydroxy-2-nitropheny]) - acetamid, 4.2 parts cls [2 (2,4-Dichl orphenyl) - 2 (IH-imidazo] - l-y] methy]) - I, 3-dioxo] an-4-yl methy]] - methansul fonat. 3 parts of Kal iumearbonat and 90 parts of N, N-Dimethy] form amide 16 to 18 h at a temperature of 120°C one agitates, one cools down then and one pours in water. The product is extracted twice with you] ormethan. The united Dichlormethanextrakte is washed, dried, filtered and evaporated twice with Ka] iumcarbonat] ösung. The arrears are taken up in 80 parts of Methano] and shifted then with 2 parts of a 30%igen Natriummethano] RK] ösung. The mixture is agitated 1 h under Rfickfluß and poured then in water. The organic layer is dried, filtered and eingedarnpft. The arrears are transferred in 2-Propanol into the appropriate Hydroch] orid. The received salt is filtered off and L, O from ethanol is isiert umkristal]. Yield of 1.3 parts (25% d.Th.) of ois-5 [2 (2.4-Dich] orphenyl) - 2 (IH-imidazo] - l-y] methyl) - l, 3 - - dioxo] an-4-y] methoxy] - 2-nitrophenylaminmonohydroch] orid; Fp. 242,9 °C. Example 52: In accordance with example 51, however quantities of the appropriate parent compounds enter under employment äquiva], are manufactured the following connections: N 11 N I CH2 o I C] cis CH C2Hs I base or salt base base CH 2 - CH 2 - CH 3 CH {CH,) 2 (CH 2}, - CH 3 CH2-CH (CH) 2 CH (CH 3} - cm 2 - CH 3 CO-CH 3 SO2-OH CH2-C “Hs CöHs base base base base base base base i/2 H2 0 base base Fp. i 126, I°C 122,2°C I15,6°C 116,3°C III, 4°C 120,3°C lOO, 5°C 176,4°C 152,1°C 107,10C 134,1°C example 53: A mixture from 25 parts of cis l [4 [2 (2,4-DJchlorphenyl) - 2 (IH-imidazol-l-ylmethyl) - l, 3-dJoxol an-4-y], gekühntes in the Wasserbad, methoxy] - phenyl] - piperazin, 27.7 parts potassium carbonate and 375 parts of Trich] ormethan is more ensäurechloridmethylester shifted at a temperature of 20 to 23°C under agitating drop by drop with 5,7 parts Koh]. After completion of the addition agitating 2 h is continued. The Beaktionsgm, nisch is filtered over Byf] o. The Fi] stepped is evaporated, and the arrears are transferred of a small quantity of Methano in a mixture from 4-Methyl-2-pentanon,] and 2-Propanol into the appropriate Hydroeh] orid. The salt is filtered off and dried. Yield of 23 parts (74.15% d.Th.) of cis Methy] - 4 {4 [2 (2,4-dich] orpheny]) - 2 (iH-imidazol-l-y] methyl) - - I, 3 - dioxo] an-4-ylmethoxy] - phenyl - E-1-piperazincarboxy] atdihydrochIorld; Fp. 192,9°C. Example 54: In accordance with example 53, however quantities of the appropriate parent compounds equivalent under employment, are manufactured the following connections: cis-MethyI-4 {4 - [2 (2,4-dichl orpheny]) - 2 (IH-1,2,4-triazol-l-y] methy]) - 1,3-dioxo] an-4-ylmethoxy] - pheny]] - l-piperazincarboxy] RKs; Fp. 134,7°C. ci s-Äthy] - 4 - {4 - [2 - (2,4-dlch] orpheny I) - 2 - (1H-l, 2,4-tri azo] - l-y] methy]) - 1,3-dioxol an-4-y] methexy] - - pheny]} - l-piperazincarboxyIatdihydrochlorid; Fp. 170,4°C. cis-Äthyl-4 {4 - [2 (2,4-dich] orphenyI) - 2 (1H-imidazo] - l-y] methyl) - l, 3-dioxo] an-4-y] methoxy] - - pheny]} - l-piperazincarboxylatdihydroch] orld hemihydrat; Fp. 178°C. Cis Pheny] - 4 - {4 - [2 (2,4-dl CH] orphenyl) - 2 (IH-I, 2,4-triazo] - l-ylmethyI) - i, 3-dioxo] an-4-y] methoxy] - pheny]} - l-piperazincarboxy] RK; Fp. I12,4°C. Example 55: A mixture from 1,56 parts of PropJonsäureanhydrid, 4.9 parts of cis l {4 [2 (2,4-Dich] orphenyl) - -2 (1H-1,2,4-triazo] - l-ylmethy]) - 1.3 - dioxo] an-4-y] methoxy] - pheny]} - piperazin, 2 parts of Ka] iumcarbonat and 130 parts you] ormethan is agitated 2 h at a temperature of 10°C. According to the addition of water bi] the denden layers separate. The organic layer is washed, dried, filtered and evaporated with water. The arrears become ge by Säu] enchromatographie at gravel]] using a mixture from Tricb] ormethan and Methano] (97: 3 Vo]. - Parts} as ElutJonsmitte] cleaned. The pure parliamentary groups are collected, and the E] utionsmitte] abdesti]] is iert. The arrears become in a mixture from 2,2 ' - Oxybispropan and 2-Propano] into the appropriate Hydrocb] orid transfer. The salt is triert abfi] and from a mixture from 2-Propano] and 2.2 ' - Oxybisprepan umkrista]] isiert. Exploit cis-1 {4 - [2 (2,4-Dich] orpheny]) - 2 (1H-1,2,4-triazo] - l-y] methy]) - 1,3-dioxe] an-4-y] methoxy] - phenyI} - 4 (1-oxopropyI) - piperazindihydroch] orid (l, 2 parts); Fp. 180,9°C. Example 56: In accordance with example 55, however under employment of an equivalent quantity butter acid anhydride, the following connection is made: hurrying {4 - [2 (2,4-Dich] orpheny]) - 2 (1H-I, 2,4-trl azo] -1-y] methy]) - I, 3-di oxo] an-4-y] methoxy] - phenyl} - 4 (1-oxobutyl} - piperazindihydroch] orid; Fp. 177,7°C. Example 57: A mixture from 1,34 parts of 2-Ch] oressigsäureäthy] ester, 5 parts of cis l {4 [2 (2,4-DichlorphenY]) - 2 (iH-imidazo] - l-y] methy]) - l, 3-dioxolan-4-y] methoxy] - phenyl] - piperazin, 2.75 parts of Ka] iumcarbonat and 45 parts of N, N-Dimethy] form amide 1 h is agitated at a temperature of 60°C. The reaction mixture is poured in ice water and extracted with you] ormethan. You] ormethanextrakt with water one washes, one dries, one filters and one evaporates. The oily arrears become ge by Säu] enchromatographie at gravel]] using a mixture from Methy] benzo] and Ätbano] (90: 10 Vo]. - Tei] e} as E] utionsmitte] cleaned. The pure parliamentary groups are collected, and the E] utionsmitte] abdesti]] is iert. The oily arrears are isiert from 4-Metby] - 2-pentanon umkristal]. The received connection is triert and dried abfi]. Yield 2 Tei] e cls Äthy] - 4 - {4 - [2 (2,4-dich] orpheny]) - 2 (IH-imi dazo] - l-ylmethy]) - i, 3-dioxo! on -4-y] methoxy] - pheny]} - l-piperazinacetat; Fp. 130,7°C. Example 58: A mixture from 1 part of 2-Ch] oracetamid, 5 parts of cis-1 {4 [2 (2,4-Dich] orpheny]) - 2 (] H-imidazo] - l-y] methy]) - l, .q-dioxolan-4-y] methoxy] - pheny]} - piperazin, 2.76 parts of Ka] iumcarbonat and 50 parts of Dimethy] CSU] foxyd 60 h at ambient temperature one agitates. The reaction mixture is poured in water and extracted with you] ormethan. You] ormethanextrakt with water one washes, one dries, one filters and one evaporates. The firm arrears become ge by Säu] enchromatographie at gravel]] using a mixture from Trich] ormethan and Methano] (95: 5 VOL. - Tei] e) as E] utionsmitteI cleaned. The pure parliamentary groups are collected and the EIutionsmitte] is iert abdesti]]. Yield of 1.5 parts of cis-4 {4 - [2 (2,4-Dich] orpheny]) - 2 (1H-imidazo] - l-ylmethy]) - l, 3-dioxo] on -4-y] methoxy] - pheny]} - l-piperazinacetamid; Fp. 150,2°C. Example 59: A solution of 5 parts of ÄthyIamin in 55 parts of 1,2-Äthandio] becomes under agitating with 4,5 parts of cis-Äthyl-4 {4 - [2 (2,4-dich] orpheny]) - 2 (1H-imidazo] - l-y] methy]) - l, 3-dioxe] an-4-y] methoxy] - phenyI} - l-piperazinacetat transferred. The mixture is agitated only 5 h at a temperature of 40°C and then further 46 h at ambient temperature. The reaction mixture is poured in water and extracted with Dichlormethan. The DichIormethanextrakt is dried, filtered and evaporated. The oily Rfickstand becomes from a mixture from ethyl acetate and 2.2 ' - Oxybispropan umkrista] lisiert. The received connection is filtered off and dried. Yield of 3 parts of cis-44 [2 (2,4-Dich] orphenyl) - 2 (IH-imidazol-l-ylmethyl) - l, 3-dioxolan-4-ylmethoxy] - phenyll N ETHYL L plperazinacetamid; Fp. i17,2 C. Example 60: In accordance with example 59, however under employment of an equivalent quantity of Methylamin, the following connection is made: cis-4i 4 - [2 (2,4-Di chiorphenyl) - 2 (1H-imi dazol l ylmethyl) - 1, A-dioxol an-4-ylmethoxy] - phenyl} - - N-methyl-l-piperazinacetamidtrihydrochloridmonchydrat; Fp. 212,2°C. I0 example 61: A mixture from 20,7 parts of cis n (4 - [2 (2,4-Dichlorpheny]) - 2 (1H-imidazol-l-ylmethyl) - l, 3 - - dioxo] an-4-ylmethoxy] - phenyl t - Ne-methylacetamidoxalat (1: i], 15 parts of KaIiumhydroxyd and 160 parts of 2-Propano] is agitated 16 to 18 h under return flow. The Beaktionsgemisch is cooled down, poured in water and extracted with Dichlermethan. The Dichlormethanextrakt is washed, dried, filtered and evaporated with water. The arrears are transferred in ethanol into the appropriate oxalate. The received salt is filtered off. The appropriate free base is set free in usual way and from l, l - Oxybisäthan auskrista]] isiert. Yield of 9 parts (57% d.Th.) of cis-4 [2 (2,4-Dich] orphenyl) - 2 (1H-imidazol-l-ylmethyl) - l, 3-dioxo] an-4-ylmethexy] - N-methylphonylamin; Fp. I18,4°C. Example 62: A mixture from 58,7 parts of cis la Acety] - 44 - [2 (2,4-dich] orphenyI) - 2 (IH-1,2,4-triazo] - l - y] methyl) - 1,3-dloxo] an-4-y] methoxy] - pheny]} - piperazin, 4.9 parts sodium hydroxide and 800 parts of l-Butano] is agitated 16 to 18 h under bending river. The reaction mixture is cooled down, poured in water and extracted with Benzo]. The benzene excerpt is washed, dried, filtered and evaporated twice with water. The arrears become by Säulenchromatographie at silicagel using a mixture from chloroform and methanol (95. “5 VOL. - Parts), satisfied with ammonia, as Elutionsmitte] cleaned. The pure parliamentary groups are collected, and that E] utionsmitte] is abdestilliert. The arrears become from 2,2” - Oxybisprepan recrystallizes. The received connection is filtered off and dried. Yield of 11.7 parts of eis-l4 [2 (2,4-Dichlorphenyl) - 2 (1H-l, 2,4-tri azol l ylmethyl) - 1,3-dioxel on -4-ylmethoxy] - phenyl t-piperazin; Fp. 130,6°C. Example 63: A mixture from 60 parts of formic acid and 6 parts of the connection received in accordance with example 63 is agitated 16 to 18 h under return flow. The reaction mixture is evaporated, and the arrears are solved in water. The solution is alkalinely stopped with ammonium hydroxide and extracted twice with Dichlormethan. The cleaned Dichlcrmethanextrakte is washed, dried, filtered and evaporated twice with water. The arrears become by Säulenchromatographie at silicagel using a mixture from chloroform, hexane and methanol (45: 45 “10 VOL. - Parts) as Elutionsmittel cleaned. The pure parliamentary groups are abdestilliert collected 0 and the Elutionsmittel. The bending and is recrystallized from 4-Methyl-2-pentanon. The received connection is filtered off and getrecknet. Yield of 2.5 parts of cis-44 [2 (2,4-Dichlorphenyl) - 2 (1H-l, 2,4-triazol-l-ylmethyl) - 1,3-dioxol on -4-y] methoxy] - phenyl} - l-piperazincarboxaldehyd; Fp. 137,3°C. Example 64 " a mixture from 2,3 parts of Benzoylchlerid, 7.35 parts of the connection received in accordance with example 63, 3 parts of Kaliumcarbenat and 130 parts of Dichlormethan is agitated 2 h at ambient temperature. The reaction mixture is washed, dried, filtered and evaporated with water. The arrears become by Säulenchromatographie at silicagel using a mixture from chloroform and methanol (95: 5 l/el. - Parts) as Elutionsmittel cleaned. The pure parliamentary groups are collected, and that Elutionsmittel is abdestilliert. The arrears are lisiert from 2,2 ' - - Oxybispropan umk£ista]. Rha] the tene connection is filtered off and dried. Yield of 1.8 parts of cis l Benzoy] - 4 - {4 - [2 (2,4-dich] orphenyl) - 2 (iH-l, 2,4-triazol-l-ylmethyl) - -1,3-dioxol an-4-ylmethoxy] - phenyl} - piperazin; Fp. 140,3°C. Example 65 " a mixture from 1,3 parts methane sulphonyl chloride, 4.9 parts of cis l {4 [2 (2,4-Dichlorpheny]) - -2 (IH-imidazol-l-ylmethy]) - l, 3-dioxolan-4-y] methoxy] - phenyl} - piperazin, 3 parts of Ka] iumcarbonat and 150 parts chloroform is agitated 3 h at ambient temperature. After addition of 100 parts water is continued the Bfihren I h at ambient temperature. The organic phase is separated, dried, filtered and evaporated. The arrears are digested in a mixture from 4-MethyI-2-pentanen and 5 drops water. By addition of 2,2 ' - Oxybispropan is precipitated the product. It is triert abfi] and isiert from 4-Methyl-2-pentanon umkrlstal]. Yield of 5 parts of cis l {4 - [2 (2,4-Dich] orpheny]] - 2 (1H-imidazo] - l-ylmethyI) - l, 3-dioxolan-4 - y] methoxy] - pheny]] - 4 (methy CSU] fonyl) - piperazinmonohydrat; Fp. ll3°C. Example 66: Gemäht example 65, however quantities of the appropriate parent compounds equivalent under employment, are manufactured the following connections: cis-1 (4 - [2 (2,4-DichIorpheny! ) - 2 (1H-imidazel-l-y] methy]) - l, 3-dioxo] an-4-yl methoxy] - pheny] lIs -4 (pheny] methy] sulphonyl) - piperazin; Fp. 188,2°C. hurrying {4 - [2 (2,4-Dich] orpheny]) - 2 (1H-l, 2,4-tri azol l yl methy I) - I, 3-di oxol an-4-y] methoxy] - pheny]] - 4 (phenylmethy] sulphonyl) - piperazinmonohydrat; Fp. 135, I °C. Beispie! 67 " gaseous ethylen oxide 1 h becomes by an agitated mixture from 5 parts of cis i {4 [2 (2.4 - - Dichlorphenyl) - 2 (IH-imidazol-l-ylmethyl) - l, 3-dioxolan-4-ylmethoxy] - phenyl} - piperazin and 80 parts methanol led, whereby under Rückf] uß it is heated up. The Beaktionsgemisch is then evaporated. The arrears become by Säulenchromatographie at silicagel using a mixture from Trich] ormethan and Methano] (95: 5 VOL. - Tei] e) as E] utionsmittel cleaned. The pure parliamentary groups are collected, and the Elutionsmittel is iert abdestil]. The oily arrears are recrystallized from a mixture from Benzo] and petroleum ethers. The received connection is filtered off and dried. Yield of 2 parts of cis-4 {4 - [2 (2,4-Dichlorphenyl) - 2 (1H-imidazoI-l-ylmethyl) - l, 3-dioxolan-4 - ylmethoxy] - phenyl} - l, piperazinäthanol; Fp. 146,4°G. A mixture from 5,3 parts of the received connection, 50 parts of Dimethylsu] foxyd and 45 parts benzene is agitated up to the complete dissolution and shifted then with 0,622 parts of a sodium hydride dispersion (76%). The mixture is continued to agitate at ambient temperature up to the completion of the gassing. After the addition of 2,2 parts bromine ethane is agitated the mixture 16 to 18 h at ambient temperature. Then further 2 parts bromine ethane in 2 portions are admitted, whereby between the additions one time interval of 2 h lies in each case. The reaction mixture is poured in ice water and extracted with Dichlormethan. The Dichlormethanextrakt is washed, dried, filtered and evaporated with water. The oily arrears become by Säulenchromatographie at silicagel using a mixture from chloroform and methanol (95: 5 VOL. -. Parts) as Elutionsmittel cleaned. The pure parliamentary groups are collected, and that Elutionsmittel is abdestilliert. The oily arrears are recrystallized from 4-Methyl-2-pentanon. The received connection is filtered off and dried. Yield of 2.7 parts of cis l {4 - [2 (2,4-Dichlorphenyl) - 2 (1H-imidazol-l-ylmethy]) - l, 3-dioxolan -4-ylmethoxy] - phenyl] - 4 (2-äthoxyäthy]) - piperazin; Fp. 140 to 145,4°C. Example 68: A mixture from 5 parts of cis l Acety] - 4 {4 [2 (2,4-dichlorpheny]) - 2 (IH-imidazo] - l-ylmethy]) - 45-l, 3-dioxolan-4-ylmethoxy] - phenyl] - piperazin, I part lithium aluminum hydride and 90 parts tetrahydrofurane is agitated I week at ambient temperature. The reaction mixture is decomposed by gradual addition by I part water, 1.5 parts of a 50%igen sodium hydroxide] ösung and 3 parts water. The formed precipitation is abfiltrisrt, and the Fi] stepped one evaporates. The arrears are transferred in methanol into the appropriate oxalate. The formed salt is triert and dried abfi]. Yield of 3.7 parts (56% d.Th.) of cis l {4 - [2 (2,4-Dichlorpheny]) - 2 ('IH-imidazoi-l-y] methyl) - l, 3 - - dloxol an-4-y] methoxy] - phenyl) - 4-äthy] piperazinoxalat; Fp. 168,7 °C. - 35 - NR, 366683 example 69: A mixture from 60 parts of cis la Acety] - 4 - {4 - [2 (2,4-dich] orpheny]) - 2 (1H-imidazo] - l-y] methy]) - -1,3-dioxolan-g-y] methoxy] - phenyl! - piperazin and 400 parts of 4-Methy] - 2-pentanon is heated up under return flow and treated with activated charcoal. The Aktivkoh] e is then filtered off and the filtrate s on a temperature of for instance 30°C is cooled down. The filtrate is then shifted slowly with 29 parts of 2-Propanol and satisfied under agitating with gaseous Ghlorwassersteff. ] Orid one lets the formed Hydrech crystallize in 3 h. It is filtered off and recrystallized twice from 2-Propanel. Yield of 38 parts of eis-l-Acetyl-4 {4 - [2 (2,4-dichlorphenyl) - 2 (iH-imidazol-l-y] methy]) - I, 3-diexelan-4-ylmethoxy] - phenyl] - piperazindihydrechlorid; Fp. 219,3°C. Example 70: A mixture from 5,3 parts of cis-4 {4 - [2 (2,4-Dich] orphenyl) - 2 (1H-imidazo] - l-y] methy]) - l, 3 - - dioxolan-4-ylmethoxy] - phenyl} - 1-piperazin-äthanol and 90 parts benzene is agitated and warmed up, until the entire solid goes into solution. Then 0.5 by portion parts of sodium hydride dispersion (50 industrial union) are added. After 15 min 4.28 parts of Propyl-4-methylbenzolsulfonat are drop by drop added to long agitating. After terminated addition agitating is continued first over night at the return flow, then during one weekend at ambient temperature and on that further 8 h long at the return flow. The reaction mixture is cooled down and cast in water. The product is extracted 3mal with Dichlormethan. The united excerpts are washed, dried, filtered and evaporated 3mal with water. Arrears are cleaned 2mal by Säulenchrematographie over silicagel, whereby first a mixture from chloroform and methanol (Velumsverhältnis 98: 2) and then a mixture from witches, chloroform and methanol (VOL around relationship 47,5: 47,5 • 5) when Elutionsmittel are used. The arrears become in 2,2 ' - Oxybispropan digests. The product is filtered off and dried, the yield amounts to 0,5 parts of cis l {4 - [2 (2,4-Dichlerphenyl) - 2 (IH-imidazol-l-ylmethyl) - 1,3-dioxolan-4-ylmethoxy] - phenyl -4 (2 - - prepoxyäthyl) - piperazin, Fp. 129,5°C. Example 71: A mixture from 1,8 parts (2-Methoxyäthyl) - methansulfonat, 4.9 parts of cis l (4 [2 (2,4-Dichlorphenyl) - 2 (iH-imidazol-l-y] methyl) - i, 3-dioxo! an-4-ylmethoxy] - phenyl) - piperazin, 1.2 parts of N, N-Diäthyläthanamin and 68 parts of N, N-dimethylformamide is agitated 2 h long with 100°C. The whole is agitated over the weekend at ambient temperature. The reaction mixture is cast in water and the product is extracted 3mal with Benzo]. The united excerpts are washed with water, cleaned dried, filtered and evaporated, the arrears by Säulenchromatographie at silicagel, whereby a mixture from chloroform and methanol (VOL. - Relationship 98: 2) when Elutionsmitte is used]. The pure parliamentary groups are caught and the E] utionsmitte] are evaporated. The arrears become in 2,2 ' - Oxybispropan digests. The product is filtered off and from l, l' Oxybisbutan crystallizes, whereby I, I of parts of cis-1 {4 - [2 (2,4-Diehlorphenyl) - 2 (1H-imidazol-l-ylmethyl) - I, 3-dioxolan-4-ylmethoxy] - - pheny]} - 4 (2-methoxyäthyl) - piperazin, Fp. 115,3°C, to be received. 0 example 72: A mixture from 1,6 parts of 2-Propanol, 8 parts of cis l {4 [2 (2,4-Diehlorphenyl) - 2 (IH-imidazol - l-y] methyl) - l, 3-dioxolan-4-ylmethoxy] - phenyl] - piperazin and 120 parts methanol with normal print and at ambient temperature with 2 parts platinum up resole Ratalysator is hydrogenated. After admission of the computed landing on water EFF quantity the catalyst is triert abfi] and the filtrate becomes eingeh5 steams. The arrears are agitated with 2,2 ' - Oxybispropan. The product is filtered off and getroeknet, whereby 5.2 parts of cls l {4 - [2 (2,4-Dichlorpheny]) - 2 (IH-imidazo] - l-y] methy]) - l, 3-dioxo] on -4-y] methoxy] - pheny]} - 4 (2-methyIpropyl) - piperazin, Fp. 105°C, to be received. According to the methods described in the understanding examples also the following connections can be represented: cis-Methyl-4 {4 - [2 (2,4-dichlorphenyl) - 2 (IH-imidazol-l-ylmethyl] - l, 3-dioxo] an-4-ylmethoxy] - - pheny] 1-1-piperazinacetat, Fp. 138,9 °C. cis (1-Methy] äthy]) - 4 - {4 - [2 (2,4-dichlorphenyl) - 2 (iH-imidazo] - 1-y] methy]) - l, 3-diexolan-4-ylmethoxy] - phenyl} - l-piperazinacetat, Fp. 104,9 “0. ci s-4 {4 - [2 - (2,4-Dl chl orpheny]) - 2 - (1 H-l, 2,4-tri azol - l-y] methy]) - i, 3-dioxo] an-4-y] methoxy] - phenyl] - N-propyl-l-piperazincarboxamid, Fp. 118,4°C. cis-4 {4 - [2 (2,4-Dich] orpheny]) - 2 (IH-I, 2,4-triazo] - l-y] methy]) - 1,3-dioxolan-4-ylmethoxy] - phenyl} - N-ethyl-l-piperaz ncarbothioamid, Fp. 176,4 " C. cis-4 {4 - [2 (2,4-Dich] orpheny]) - 2 (IH-I, 2,4-triazo] - l-ylmethy]) - i, 3-dioxolan-4-y] methoxy] - pheny]} - N-methyl-l-piperazincarbothioamid, Fp. 140,9°C. cis-Methyl-4 {4 - [2 (2,4-dichlorphenyl) - 2 (1H-1,2,4-triazol-l-ylmethyl) - l, 3-dioxolan-4-y] methoxy] - phenyl} -, Fp l-piperazincarbodithioat. 109,7°C. cis-4 {4 - [2 (2,4-Dich] orpheny]) - 2 (1H-1,2, - triazo] - l-y] methyl) - 1,3-dioxolan-4-y] methoxy] - pheI0 nyl} - N, N-diäthy] - l-pJperazincarboxamidmonohydrat, Fp. 88,6°C. cis-4 {4 - [2 (2,4-Dich] orpheny]) - 2 (IH-1,2,4-tri azo] - l-ylmethy]) - 1,3-dl oxol an-4-yl methoxy] - pheny]} - N, N-dimethy] - l-piperazincarboxamid, Fp. 139,2°C. Cis n {4 - [2 (2,4-Di chl orpheny]) - 2 (1H-I, 2,4-triazol-l-ylmethy]) - 1,3-dioxo] an-4-ylmethoxy] - phenyl} - acetam D, Fp. 163,9°C. cis-4 [2 (2,4-DJch] orpheny]) - 2 (IH-l, 2,4-triazo] - l-y] methy]) - I, 3-dioxolan-4-y] methoxy] - benzo] - amJn, Fp. 128,2°C. cis-1 {2 (2,4-Dich] orpheny]) - 4 - [(4-isothiocyanatophenoxy) - methy] 1 - l, 3-dioxolan-2-y] methy]] - - iH-l, 2,4-triazo], Fp. 143,9°C, cis n {4 - [2 (2,4-Dich] orpheny]) - 2 (1H-1,2,4-triazo] - l-y] methy]) - l, 3_dioxo] an_4_y] methoxyI _ - pheny]] - thiourea dihydrate, Fp. 106 1°C. cis-44 [2 (2,4-Dich] orphenyl) - 2 (IH-irnidazo] - l-y] methyl) - i, 3-dioxo] an-4-y] methoxy] - pheny]} - - N-propy] - 1-piperazinacetamid, Fp. I02,7°C. cisI {4 - [2 (2,4-Di CH] orpheny]) - 2 (1H-I, 2,4-triazo] - l-y] methy]) - 1,3-dioxo] an-4-y] methoxy] - pheny]} - l-piperazinacetamid, Fp. 163°C. Trans l Acety] - 4 - {4 - [2 - (2,4-di CH] orpheny]) - 2 - (1Hmidazo] - 1 - y] methy]) - I, 3-dioxo] an-4-y] methoxy] - - phenyl] - piperazJnäthandioat (l; l) - mono hydrate, Fp. I14,4°C. Cis Pheny] - [4 - [2 (2,4-dl CH] orpheny]) - 2 (IH-I, 2,4-tri azo] - l-y] methy]) - I, 3-dioxo] on-q-y] methoxy] - - pheny]) - carbamat, Fp. 168,5°C. Cis Butyl {4 - [2 (2,4-dich] orphenyl) - 2 (IH-imidazo] - l-y] methyl) - 1,3-dioxo] an-4-ylmethoxy] - pheny]} - carbamat, Fp. 160,3°C. Cis la Methyläthy] - {4 - [2 (2,4-dich] orpheny]) - 2 (IH-imidazo] - l-y] methy]) - l, 3-dioxolan-4-ylmethoxy] - pheny]] - carbamat, Fp. 177,6°C. CJs Propy] - {4 - [2 (2, q-you] orphenyl) - 2 (1H-imi dazo] - l-y] methy]) - i, 3-dioxo] an-4-y] methoxy] - pheny]} - carbamat, Fp. 169,5°C. cis-2-t lethylpropy] - {4 - [2 (2,4-dich] orpheny]) - 2 (lI1-imidazo] - l-y] methy]) - i, 3-dJoxo] an-4-ylmethoxyl-pheny]] - carbamat, Fp. 188,6°C. cis la propy] - {4 - [2 (2,4-dichlorpheny]) - 2 (IH-imidazo] - l-y] methyl) - I, 3-dioxo] an-4-y] methoxyl phenyl} - carbamat, Fp. 148,7°C. cis q {4 - [2 (2,4-Dich] orphenyl) - 2 (1H-1,2,4-tri azol l y] methy]) - I, 3-dioxo] an-4-yl methoxy] - phenyl} - l-piperazinäthano], Fp. 153,1°C. cis l {4 - [2 (2,4-DiGh] orphenyl) - 2 (IH-imidazo] - l-ylmethyl) - l, 3-dioxolan-4-ylmethoxy I - pheny]} - -4-äthy] piperazin, Fp, 121.8 b s 143,2°C. Cis i {4 - [2 (2.4 - close orphenyl) - 2 (IH-l, 2,4-triazol-l-y] methy]) - I, 3-d oxo] an-4-y] methoxy] - pheny]] - 4 (2-propGxyäthy]) - piperazin, Fp. I00,3°C. cis-1 {4 - [2 (2,4-Dich] orpheny]) - 2 (iH-imi dazo] - l-y] methy]) - I, 3-dioxo] an-4-y] methoxy] - pheny]} - -4 (2-methy] buty]) - piperazln, Fp. 97,5 °C. ci s-l {4 - [2 (2,4-Dich] orpheny]) - 2 (1H-I, 2,4-tri azo] - l-y] methyl) - I, 3-dioxol an-4-yl methoxy] - phenyl] - 4 (2-methoxyäthy]) - piperazin, Fp. 101,1 °C. cis-1 {4 - [2 (2,4-Dich] orpheny]) - 2 (1H-imidazo] - l-y] methy]) - 1,3-dioxo] an-4-ylmethoxy 1 - pheny]] - 50-4-penty] piperazin, Fp. I06,8°C. ci s-l {4 - [2 (2,4-D CH] orpheny]) - 2 (1H-imi dazo] - 1-y] methy]) - 1,3-dioxo] an-4-y] methoxy] - pheny]} - -4 (3-methy] buty]) - piperazin, Fp. 129,9 °C. cis l (4 - [2-C2,4-Dichlorpheny]) - 2 (IH-imidazol-l-ylmethy]) - 1,3-dioxo] an-4-ylmethoxy] - phenyl I - -4 (2,2-dimethy] propyl) - piperazin, Fp. 115,1°C. cis-1 (4 - [2 (2,4-Dich] orpheny]) - 2 (IH-1,2,4-tri azo] - l-y] methyl) - I, 3-dioxol an-4-y] methoxy] - pheny] 1-4-hexy] piperazin, Fp. 98°C. cis-1 {4 - [2 (2,4-Dich] orphenyl) - 2 (IH-1,2,4-triazol-l-y] methy]) - l, 3-dioxo] an-4-ylmethoxy] - pheny]} - 4-C3-methy] buty]) - piperazin, Fp. 101,8°C. cis-1 (4 - [2 (2,4-Dichlorphenyl) -2 (IH-1,2,4-tri azol l ylmethyl) - l, 3-dl oxo] an-4-y] methoxy] - pheny]} - 4-penty] piperazin, Fp. 85.1°C. cis-1 (4 - [2 - (2, 4 - you] 0 rpheny]) - 2 - (1 H-imidaz0] - 1 - y] methy]) - 1, 3 - di0 x0 lan-4-y] meth0 XY] - pheny] I - 1O-4-hexy] piperazin, Fp. 97,3°C. ci s-l (4 - [2 - (2.4-Di CH] orphenyl) - 2 (iH-imi dazol l yl methyl) - i, 3-dioxol an-4-y! methoxy] - pheny]) - -4 (1-äthy] propy]) - piperazin, Fp. 92,8°C. cis l (4 - [2 (2.4-Dich] orpheny]) - 2 (IH-1,2,4-tri azol l y] methy]) - I. 3-dioxo] an-4-y] methoxy] - pheny] 1-4 (1-methylbuty]) - piperazin, Fp. 109,6°C. cis-1 (- [2 (2,4-Dich] orph ny]) - 2 (IH-I, 2,4-triazo] - l-ylmethy]) - 1,3-dioxo] an-4-y] methoxy] - pheny] l-4-C 2,2-dimethy] propy]) - piperazin, Fp. 110,3 °C. cis-1 (4 - [2 (2,4-Dichlorpheny]) - 2 (eat l, 2,4-tri azol l y] methy]) - i, 3-dioxo] an-4-y] methoxy] - pheny]} - 4 (1-äthylpropyl) - piperazin, Fp. 104°C. cis-1 (4 - [2 (2,4-Dich] orpheny]) - 2 (1H-imidazo] - l-y] methy]) - 1,3-dioxo] an-4-y] methoxy] - pheny] I - -4 (1-methylbuty]) - piperazin, Fp. 91°C.