MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. The compound according to claim 1 , wherein X and Y are independently chosen from H or C(O)R.3. The compound according to claim 2 , wherein Ris independently chosen from H claim 2 , alkyl claim 2 , alkenyl claim 2 , aryl claim 2 , heterocyclyl claim 2 , silyl claim 2 , —C(O)R claim 2 , each substituted with 0 claim 2 , 1 or multiple R.4. The compound according to claim 3 , wherein Ris independently phenyl or cyclohexyl.5. The compound according to claim 4 , wherein Ris alkyl or aryl substituted with 0 claim 4 , 1 claim 4 , or multiple R.6. The compound according to claim 5 , wherein Ris alkoxy or benzyloxy substituted with 0 claim 5 , 1 claim 5 , or multiple R.7. The compound according to claim 6 , wherein Ris hydrogen or alkyl.8. The compound according to claim 1 , wherein X is H and Y is Q.10. The compound according to claim 9 , wherein Ris independently chosen from alkyl claim 9 , aryl claim 9 , or —C(O)R claim 9 , each substituted with 0 claim 9 , 1 or multiple R.11. The compound according to claim 10 , wherein Ris phenyl.12. The compound according to claim 11 , wherein Ris alkyl substituted with 0 claim 11 , 1 claim 11 , or multiple R.13. The compound according to claim 12 , wherein Ris alkyl claim 12 , aryl claim 12 , alkoxy claim 12 , or halo.14. A composition for the control of a fungal pathogen including at least one of the compounds according to and a phytologically acceptable carrier material.16Mycosphaerella graminicolaSeptoria triticiPuccinia triticinaPuccinia striiformisVenturia inaequalisUstilago maydisUncinula necatorRhynchosporium secalisMagnaporthe griseaPseudoperonospora cubensisPhakopsora pachyrhiziLeptosphaeria nodorumBlumeria graministriticiBlumeria graminishordeiErysiphe cichoracearumGlomerella lagenariumCercospora beticolaAlternaria solaniPyrenophora teres. The composition according to claim claim 1 , 14 wherein the plant pathogen is at least one ...

MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. A compound according to claim 1 , wherein:{'sub': '6', 'wherein, R is H, C(O)R;'}{'sub': 1', '6, 'Ris H, C(O)R;'}{'sub': 2', '5, 'Ris independently or separately H, alkyl, alkenyl, aryl, each substituted with 0, 1 or multiple R;'}{'sub': '3', 'Ris independently or separately H, methyl;'}{'sub': '5', 'Ris alkyl, alkoxy, halo, haloalkyl, or aryl; and'}{'sub': '6', 'Ris alkoxy, benzyloxy.'}5Mycosphaerella graminicolaSeptoria triticiPuccinia triticinaPuccinia striiformisVenturia inaequalisUstilago maydisUncinula necatorRhynchosporium secalisMagnaporthe griseaPseudoperonospora cubensisPhakopsora pachyrhiziLeptosphaeria nodorumBlumeria graministriticiBlumeria graminishordeiErysiphe cichoracearumGlomerella lagenariumCercospora beticolaAlternaria solaniPyrenophora teres. The compositions according to claim 4 , wherein the plant pathogen is least one pathogen selected from the group consisting of: Leaf Blotch of Wheat (; anamorph: ) claim 4 , Wheat Brown Rust () claim 4 , Stripe Rust () claim 4 , Scab of Apple () claim 4 , Blister Smut of Maize () claim 4 , Powdery Mildew of Grapevine () claim 4 , Barley scald () claim 4 , Blast of Rice () claim 4 , Downy Mildew of Cucurbits () claim 4 , Rust of Soybean () claim 4 , Glume Blotch of Wheat () claim 4 , Powdery Mildew of Wheat (f. sp. ) claim 4 , Powdery Mildew of Barley (f. sp. ) claim 4 , Powdery Mildew of Cucurbits () claim 4 , Anthracnose of Cucurbits () claim 4 , Leaf Spot of Beet () claim 4 , Early Blight of Tomato () claim 4 , and Net Blotch of Barley ().6Septoria triticiPuccinia triticinaPhakopsora pachyrhizi. The composition according to claim 5 , wherein the fungal pathogen is at least one of Leaf Blotch of Wheat () claim 5 , Wheat Brown Rust () claim 5 , and Rust of Soybean ().8. The method according to claim 7 , wherein the compound is applied in a mixture with at least one additional compound selected from the group ...

INHIBITORS OF THE ACTIVITY OF COMPLEX III OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF FOR TREATING DISEASES

The present invention relates to compounds which are inhibitors of the activity of Complex III of the mitochondrial electron transport chain and pharmaceutical compositions comprising said compounds alone or in combination with other active agents. The present invention further relates to use of the compounds of the invention as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit. More particularly the present invention relates to the use of the compounds of the invention in a method of treating and/or preventing cancers presenting tumor-initiating cells. (Formula I) (I) 135.-. (canceled)37. The compound of claim 36 , wherein Ar is selected from (C5-C6)aromatic ring or (C5-C6)heteroaromatic ring where one or more of the carbon atoms in the ring system are replaced by heteroatoms selected from the group consisting of O claim 36 , S claim 36 , and N.38. The compound of claim 37 , wherein Ar is (C5-C6)aromatic ring.39. The compound of claim 36 , wherein A1 is —(C═O)—.40. The compound of claim 36 , wherein Aand Aare —C(═O)—.41. The compound of claim 36 , wherein Band Bare independently of each other selected from —O— claim 36 , —S— claim 36 , —NH— claim 36 , —CH— claim 36 , with the proviso that at least one of Band Bis not —O—.42. The compound of claim 36 , wherein Rand Rform together a (C3-C10)cycloalkyl or (C3-C10)heterocycloalkyl substituted by Rand R claim 36 , where Rand Rare independently of each other selected from —H claim 36 , —(C1-C10)alkyl claim 36 , —(C1-C10)alkenyl claim 36 , —(C1-C10)alkynyl claim 36 , mono or polyfluorinated (C1-C10)alkyl claim 36 , -aryl claim 36 , —OH claim 36 , —O—(C1-C10)alkyl claim 36 , —O—aryl claim 36 , —O(C═O)—(C1-C10)alkyl claim 36 , —O(C═O)-aryl claim 36 , and halogen.43. The compound of claim 36 , wherein R claim 36 , Rand Rare —H.44. The compound of claim 36 , wherein Rand Rform a bond together.45. The compound of claim 44 , wherein Aand Aare —C(═O)— and Ris H.46 ...

MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY

This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. The compound according to claim 1 , wherein X and Y are hydrogen.3. The compound according to claim 2 , wherein Ris selected from the group consisting of hydrogen claim 2 , alkyl claim 2 , alkenyl claim 2 , and aryl claim 2 , each optionally substituted with 0 claim 2 , 1 claim 2 , or multiple R.4. (canceled)5. The compound according to claim 2 , wherein Ris independently selected for Rand Rfrom the group consisting of hydrogen claim 2 , alkyl claim 2 , alkenyl claim 2 , and aryl claim 2 , each optionally substituted with 0 claim 2 , 1 claim 2 , or multiple R.6. The compound according to claim 1 , wherein X is C(O)Rand Y is hydrogen.7. The compound according to claim 6 , wherein Ris selected from the group consisting of hydrogen claim 6 , alkyl claim 6 , alkenyl claim 6 , and aryl claim 6 , each optionally substituted with 0 claim 6 , 1 claim 6 , or multiple R.8. (canceled)9. The compound according to claim 6 , wherein Ris independently selected for Rand Rfrom the group consisting of hydrogen claim 6 , alkyl claim 6 , alkenyl claim 6 , and aryl claim 6 , each optionally substituted with 0 claim 6 , 1 claim 6 , or multiple R.10. The compound according to claim 1 , wherein X is hydrogen and Y is Q.11. The compound according to claim 10 , wherein Ris alkoxy.12. The compound according to claim 11 , wherein Ris hydrogen.13. The compound according to claim 12 , wherein Ris selected from the group consisting of hydrogen claim 12 , alkyl claim 12 , alkenyl claim 12 , and aryl claim 12 , each optionally substituted with 0 claim 12 , 1 claim 12 , or multiple R.14. (canceled)15. The compound according to claim 12 , wherein Ris independently selected for Rand Rfrom the group consisting of hydrogen claim 12 , alkyl claim 12 , alkenyl claim 12 , and aryl claim 12 , each optionally substituted with 0 claim 12 , 1 claim 12 , or multiple R.16. The compound according to claim 11 , ...

USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. A composition according to claim 1 , wherein X is hydrogen and Y is Q.3. A composition according to claim 2 , wherein Ris alkoxy.4. A composition according to claim 3 , wherein Ris hydrogen.5. A composition according to claim 4 , wherein Ris selected from the group consisting of hydrogen claim 4 , alkyl claim 4 , alkenyl claim 4 , and aryl claim 4 , each optionally substituted with 0 claim 4 , 1 claim 4 , or multiple R.6. (canceled)7. A composition according to claim 4 , wherein Ris independently selected for Rand Rfrom the group consisting of hydrogen claim 4 , alkyl claim 4 , alkenyl claim 4 , and aryl claim 4 , each optionally substituted with 0 claim 4 , 1 claim 4 , or multiple R.8. A composition according to claim 3 , wherein Ris selected from the group consisting of —C(O)Rand —CHOC(O)R.9. A composition according to claim 8 , wherein Ris alkyl claim 8 , optionally substituted with 0 claim 8 , 1 claim 8 , or multiple R.10. A composition according to claim 9 , wherein Ris selected from the group consisting of hydrogen claim 9 , alkyl claim 9 , alkenyl claim 9 , and aryl claim 9 , each optionally substituted with 0 claim 9 , 1 claim 9 , or multiple R.11. (canceled)12. A composition according to claim 9 , wherein Ris independently selected for Rand Rfrom the group consisting of hydrogen claim 9 , alkyl claim 9 , alkenyl claim 9 , and aryl claim 9 , each optionally substituted with 0 claim 9 , 1 claim 9 , or multiple R.13. A composition according to claim 12 , wherein Ris selected from the group consisting of —CH claim 12 , —CH(CH) claim 12 , and —CHOCHCH.14. A composition for the control of a fungal pathogen including at least one of the compositions of and a phytologically acceptable carrier material.15. A composition for the control of a fungal pathogen including at least one of the compositions of and a phytologically acceptable carrier material.16. (canceled)17. A ...

MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. The compound according to claim 1 , wherein X and Y are hydrogen.3. The compound according to claim 1 , wherein X is C(O)Rand Y is hydrogen.4. The compound according to claim 1 , wherein X is hydrogen and Y is Q.5. The compound according to claim 4 , wherein Ris hydrogen.6. The compound according to claim 4 , wherein Ris —C(O)Ror —CHOC(O)R.7. The compound according to claim 6 , wherein Ris alkyl or alkoxy claim 6 , each optionally substituted with 0 claim 6 , 1 claim 6 , or multiple R.8. The compound according to claim 7 , wherein Ris chosen from —CH claim 7 , —CH(CH) claim 7 , —CHOCHCH claim 7 , or —CHCHOCH.9. A composition for the control of a fungal pathogen including at least one of the compounds of and at least one additional compound selected from the group consisting of: a phytologically acceptable carrier material claim 1 , a second fungicide claim 1 , an insecticide claim 1 , a nematocides claim 1 , a miticide claim 1 , an arthropodicide claim 1 , a bactericide.10. The composition for the control of a fungal pathogen according to claim 9 , wherein the at least one additional compound is at least one phytologically acceptable carrier material.11Mycosphaerella graminicolaSeptoria triticiPuccinia triticinaPuccinia striiformisVenturia inaequalisUstilago maydisUncinula necatorRhynchosporium secalisMagnaporthe griseaPhakopsora pachyrhiziLeptosphaeria nodorumBlumeria graministriticiBlumeria graminishordeiErysiphe cichoracearumGlomerella lagenariumCercospora beticolaAlternaria solaniPyrenophora teres. The compositions according to claim 9 , wherein the fungal pathogen is at least one pathogen selected from the group consisting of: Leaf Blotch of Wheat (; anamorph: ) claim 9 , Wheat Brown Rust () claim 9 , Stripe Rust () claim 9 , Scab of Apple () claim 9 , Blister Smut of Maize () claim 9 , Powdery Mildew of Grapevine () claim 9 , Barley Scald () claim 9 , Blast of ...

MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. The compound according to claim 1 , wherein X and Y are hydrogen.3. The compound according to claim 2 , wherein Ris alkyl or aryl claim 2 , each optionally substituted with 0 claim 2 , 1 or multiple R.4. The compound according to claim 2 , wherein Ris hydrogen or alkyl claim 2 , each optionally substituted with 0 claim 2 , 1 or multiple R.5. The compound according to claim 1 , wherein X is C(O)Rand Y is hydrogen.6. The compound according to claim 5 , wherein Ris alkyl or aryl claim 5 , each optionally substituted with 0 claim 5 , 1 or multiple R.7. The compound according to claim 5 , wherein Ris hydrogen or alkyl claim 5 , each optionally substituted with 0 claim 5 , 1 or multiple R.8. The compound according to claim 1 , wherein X is hydrogen and Y is Q.9. The compound according to claim 8 , wherein Ris alkyl or aryl claim 8 , each optionally substituted with 0 claim 8 , 1 or multiple R.10. The compound according to claim 8 , wherein Ris hydrogen or alkyl claim 8 , each optionally substituted with 0 claim 8 , 1 or multiple R.11. The compound according to claim 9 , wherein Ris hydrogen.12. The compound according to claim 9 , wherein Ris —C(O)Ror —CHOC(O)R.13. The compound according to claim 12 , wherein Ris alkyl or alkoxy claim 12 , each optionally substituted with 0 claim 12 , 1 claim 12 , or multiple R.14. The compound according to claim 13 , wherein Ris —CH claim 13 , —CH(CH) claim 13 , —CHOCHCH claim 13 , or —CHCHOCH.15. A composition for the control of a fungal pathogen including at least one of the compounds of Formula I and at least one additional compound selected from the group consisting of: a phytologically acceptable carrier material claim 13 , a second fungicide claim 13 , an insecticide claim 13 , a nematocide claim 13 , a miticide claim 13 , an arthropodicide claim 13 , and a bactericide.16. The composition according to claim 15 , wherein the least one ...

Flash and Glow 1,2-Dioxetanes

Compounds having chemiluminescent flash and glow properties. Also disclosed are methods using the compounds to generate light, detect and/or quantify enzymes, antigens, and/or nucleic acids. Also disclosed are kits relating to these compounds. 216.-. (canceled)17. The compound of claim 1 , wherein the cleavage of the bond cleavable by an enzyme moiety results in the generation of light at 25° C. which reaches a maximum in less than about 15 minutes.18. The compound of claim 17 , wherein the generation of light reaches a maximum in less than about 10 minutes.19. The compound of claim 17 , wherein the generation of light reaches a maximum in less than about 5 minutes.20. The compound of claim 1 , wherein the cleavage of the bond cleavable by an enzyme moiety results in the generation of light at 37° C. which reaches a maximum in less than about 15 minutes.21. The compound of claim 20 , wherein the generation of light reaches a maximum in less than about 10 minutes.22. The compound of claim 20 , wherein the generation of light reaches a maximum in less than about 5 minutes.24. A method for generating light claim 20 , comprising the steps of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(a) providing the compound of ;'}(b) providing an enzyme complex comprising an enzyme moiety which is capable of cleaving the compound;(c) contacting the enzyme complex with the compound to form a reaction mixture; and,(d) allowing the reaction mixture to generate light.2584.-. (canceled)86. An assay method for determining the presence and/or amount of an enzyme in a sample claim 20 , comprising the steps of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(a) providing the compound of ;'}(b) providing a sample suspected of comprising the enzyme which is capable of cleaving the compound so that it decomposes and generates light;(c) contacting the sample with the compound to form a reaction mixture; and,(d) detecting the light generated by the reaction mixture after addition of the ...

MACROCYCLIC COMPOUNDS, POLYMERS, AND METHODS FOR MAKING SAME

The application relates to macrocyclic compounds and related polymers, as well as to processes for synthesizing them, e.g., using olefins as starting material. 24.-. (canceled)5. The compound of claim 1 , wherein claim 1 , for the compound of Formula I claim 1 , the number of atoms comprising the ring structure is between 13 and 19.6. The compound of claim 1 , wherein X is O.7. The compound of claim 1 , wherein X is NH.8. The compound of claim 1 , wherein Z is hydrogen.10. The compound of claim 1 , wherein Ris optionally substituted linear CCalkyl branched C-Calkyl claim 1 , unsubstituted linear C-Calkyl claim 1 , optionally substituted linear C-Calkenyl claim 1 , unsubstituted linear C-Calkenyl or branched C-Calkenyl.1113.-. (canceled)14. The compound of claim 1 , wherein Ris optionally substituted linear CCalkyl claim 1 , unsubstituted linear CCalkyl or branched C-Calkyl.15. The compound of claim 1 , wherein Ris linear CCalkyl or branched C-Calkyl substituted with one or more hydroxyl groups.16. (canceled)17. The compound of claim 1 , wherein Ris optionally substituted linear C-Calkenyl claim 1 , unsubstituted linear C-Calkenyl or branched C-Calkenyl.18. (canceled)19. The compound of claim 1 , wherein Ris optionally substituted linear C-Calkynyl claim 1 , unsubstituted linear C-Calkynyl or branched C-Calkynyl.20. (canceled)24. (canceled)25. The method of claim 23 , further comprising an amidation step claim 23 , wherein a compound of Formula I claim 23 , wherein X is O claim 23 , reacts with NHunder an elevated pressure to obtain a corresponding compound of Formula I claim 23 , wherein X is NH.26. (canceled)27. The method of claim 23 , wherein the esterification step is performed at a first temperature that is greater than room temperature claim 23 , and the etherification step is performed at a second temperature that is lower than the first temperature.2833.-. (canceled)34. The method of claim 23 , wherein the etherification step is quenched with a base.35. ( ...

SYNTHESIS AND USE OF ISOTOPICALLY LABELED MACROCYCLIC COMPOUNDS

Disclosed herein are isotopically labeled antifungal antibiotics and related compounds. Also disclosed are methods for synthesizing these isotopically labeled molecules and using the same to study the distribution of these compounds in the biosphere as well as the products formed by the breakdown of these isotopically labeled compounds. 4. The compound according to claim 1 , wherein Ris H.9. The compound according to claim 5 , wherein Ris Ph-C10. The compound according to claim 5 , wherein Ris Ph-UL-C.12. The method according to claim 11 , wherein the compound is (a) and the sample is a portion of a plant.13. The method according to claim 11 , wherein the compound is (a) and the sample is from a surface adjacent to a plant.14. The method according to claim 11 , wherein the compound is (a) and the sample is from a material that is in communication with a surface adjacent to a plant.15. The method according to claim 11 , where the compound is (a) and the isotopically labeled signature is contained in a portion of said compound.16. The method according to claim 11 , wherein the compound is (b) and the sample is a portion of a plant.17. The method according to claim 11 , wherein the compound is (b) and the sample is from a surface adjacent to a plant.18. The method according to claim 11 , wherein the compound is (b) and the sample is from a material that is in communication with a surface adjacent to a plant.19. The method according to claim 11 , where the compound is (b) and the isotopically labeled signature is contained in a portion of said compound. This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61/747,699 filed Dec. 31, 2012, which is expressly incorporated by reference herein.Aspects of the invention include the preparation and use of isotopically labeled compounds including radiolabeled forms of the antifungal antibiotic UK-2A and related compounds.Isotopically labeled compounds are important tools in characterizing the role ...

COMPOUNDS AND THE USE THEREOF IN METATHESIS REACTIONS

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: 2. The compound of claim 1 , wherein Ris phenyl claim 1 , 2 claim 1 ,6-dichlorophenyl claim 1 , 2 claim 1 ,6-dimethylphenyl claim 1 , 2 claim 1 ,6-diisopropylphenyl claim 1 , 2-trifluoromethylphenyl claim 1 , pentafluorophenyl claim 1 , tert-butyl claim 1 , or 1-adamantyl.3. The compound of claim 1 , wherein Ris pyrrol-1-yl claim 1 , 2 claim 1 ,5-dimethylpyrrol-1-yl claim 1 , 2 claim 1 ,5-diphenylpyrrol-1-yl claim 1 , or indol-1-yl.5. The compound of claim 1 , wherein Ris methyloxy claim 1 , ethyloxy claim 1 , or isopropyloxy.6. The compound of claim 1 , wherein Rand Rare independently a hydrogen atom claim 1 , methyl claim 1 , a halogen atom claim 1 , or methyloxy.7. A method for carrying out a metathesis reaction claim 1 , the method comprising:providing a first compound having one or more carbon-carbon double bonds; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'reacting the first compound via a metathesis reaction in the presence of a compound of .'}8. The method of claim 7 , wherein the first compound has two or more carbon-carbon double bonds.9. The method of claim 8 , wherein the metathesis reaction is a ring-closing metathesis reaction between two of the two or more carbon-carbon double bonds of the first compound.10. A method of carrying out a metathesis reaction claim 8 , the method comprising:providing a first compound having one or more carbon-carbon double bond and a second compound having one or more carbon-carbon double bonds; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'reacting the first compound and the second compound via a metathesis reaction in the presence of a compound of .'}11. The method of claim 10 , wherein the first compound and the second compound are the same compound.12. The method of claim 10 , wherein the first compound ...

NEW ADIPATE-TYPE COMPOUNDS AND A PROCESS OF PREPARING IT

New adipate-type compounds suitable as an intermediate in organic chemistry, a platform chemical for the production of other chemicals, and as a monomer and a co-monomer useful for the preparation of polymers and co-polymers. Also, a process of preparing the new adipate-type compounds from bio-based raw materials such as sugars. 2. The compound according to claim 1 , wherein n is 2.3. The compound according to claim 1 , wherein n is 3.5. The process according to claim 4 , wherein n is 2.6. The process according to claim 4 , wherein n is 3.7. The process according to claim 4 , wherein the conversion temperature of iii) is in the range of from 20 to 120° C.8. The process according to claim 4 , wherein step iii) is continued for a period of time in the range of from 5 minutes to 24 hours.9. The process according to claim 4 , wherein the conversion step of iii) is conducted at a pressure in the range of from 1 to 1000 kPa claim 4 , such as from 10 to 125 kPa.10. The process according to claim 4 , wherein the conversion step of iii) is conducted in the presence of a solvent selected from methyl lactate claim 4 , ethyl lactate claim 4 , toluene claim 4 , dichlormethane claim 4 , or mixtures thereof. The present application is a divisional of U.S. application Ser. No. 16/096,103, filed on Oct. 24, 2018, which is a U.S. National Stage of International Application No. PCT/EP2017/060702, filed on May 4, 2017, which claims the benefit of Danish Application No. PA 2016-00273, filed on May 4, 2016. The entire contents of each of U.S. application Ser. No. 16/096,103, International Application No. PCT/EP2017/060702, Danish Application No. PA 2016-00273 are hereby incorporated herein by reference in their entirety.The present invention regards a new compound suitable as an intermediate in organic chemistry, a platform chemical for the production of other chemicals, and as a monomer and co-monomer useful for the preparation of polymers and co-polymers. The invention also regards the ...

NEW ADIPATE-TYPE COMPOUNDS AND A PROCESS OF PREPARING IT

The present invention regards new adipate-type compounds suitable as an intermediate in organic chemistry, a platform chemical for the production of other chemicals, and as a monomer and co-monomer useful for the preparation of polymers and copolymers. The invention also regards the process of preparing the new adipate-type compounds from bio-based raw materials such as sugars.

Compound, mixture, liquid crystal composition, cured product, optically anisotropic body, and reflective film

An object of the present invention is to provide a compound which increases the intensity of HTP by exposure to irradiation with light such as ultraviolet rays, and a mixture including the compound. Another object of the present invention is to provide a liquid crystal composition, a cured product, an optically anisotropic body, and a reflective film.The compound of the present invention is represented by General Formula (1).

MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. A compound according to claim 1 , wherein:{'sub': '6', 'wherein, R is H, or C(O)R;'}{'sub': 1', '6, 'Ris C(O)R;'}{'sub': 2', '5, 'Ris independently or separately H, alkyl, alkenyl, aryl, each substituted with 0, 1 or multiple R;'}{'sub': '3', 'Ris independently or separately H, methyl;'}{'sub': '5', 'Ris alkyl, alkoxy, halo, haloalkyl, or aryl; and'}{'sub': '6', 'Ris alkoxy, or benzyloxy.'}5Mycosphaerella graminicolaSeptoria triticiPuccinia triticinaPuccinia striiformisVenturia inaequalisUstilago maydisUncinula necatorRhynchosporium secalisMagnaporthe griseaPseudoperonospora cubensisPhakopsora pachyrhiziLeptosphaeria nodorumBlumeria graministriticiBlumeria graminishordeiErysiphe cichoracearumGlomerella lagenariumCercospora beticolaAlternaria solaniPyrenophora teres. The compositions according to claim 4 , wherein the plant pathogen is least one pathogen selected from the group consisting of: Leaf Blotch of Wheat ( claim 4 , anamorph: ) claim 4 , Wheat Brown Rust () claim 4 , Stripe Rust () claim 4 , Scab of Apple () claim 4 , Blister Smut of Maize () claim 4 , Powdery Mildew of Grapevine () claim 4 , Barley scald () claim 4 , Blast of Rice () claim 4 , Downy Mildew of Cucurbits () claim 4 , Rust of Soybean () claim 4 , Glume Blotch of Wheat () claim 4 , Powdery Mildew of Wheat (f. sp. ) claim 4 , Powdery Mildew of Barley (f. sp. ) claim 4 , Powdery Mildew of Cucurbits () claim 4 , Anthracnose of Cucurbits () claim 4 , Leaf Spot of Beet () claim 4 , Early Blight of Tomato () claim 4 , and Net Blotch of Barley ().6Septoria triticiPuccinia triticinaPhakopsora pachyrhizi. The composition according to claim 5 , wherein the fungal pathogen is at least one of Leaf Blotch of Wheat () claim 5 , Wheat Brown Rust () claim 5 , and Rust of Soybean ().8. The method according to claim 7 , wherein the compound is applied in a mixture with at least one additional compound selected from ...

MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. The compound according to claim 1 , wherein X and Y are hydrogen.3. The compound according to claim 1 , wherein X is C(O)Rand Y is hydrogen.48.-. (canceled)9. A composition for the control of a fungal pathogen including at least one of the compounds of and at least one additional compound selected from the group consisting of: a phytologically acceptable carrier material claim 1 , a second fungicide claim 1 , an insecticide claim 1 , a nematocides claim 1 , a miticide claim 1 , an arthropodicide claim 1 , a bactericide.10. The composition for the control of a fungal pathogen according to claim 9 , wherein the at least one additional compound is at least one phytologically acceptable carrier material.11Mycosphaerella graminicolaSeptoria triticiPuccinia triticinaPuccinia striiformisVenturia inaequalisUstilago maydisUncinula necatorRhynchosporium secalisMagnaporthe griseaPhakopsora pachyrhiziLeptosphaeria nodorumBlumeria graministriticiBlumeria graminishordeiErysiphe cichoracearumGlomerella lagenariumCercospora beticolaAlternaria solaniPyrenophora teres. The compositions according to claim 9 , wherein the fungal pathogen is at least one pathogen selected from the group consisting of: Leaf Blotch of Wheat (; anamorph: ) claim 9 , Wheat Brown Rust () claim 9 , Stripe Rust () claim 9 , Scab of Apple () claim 9 , Blister Smut of Maize () claim 9 , Powdery Mildew of Grapevine () claim 9 , Barley Scald () claim 9 , Blast of Rice () claim 9 , Rust of Soybean () claim 9 , Glume Blotch of Wheat () claim 9 , Powdery Mildew of Wheat (f sp. ) claim 9 , Powdery Mildew of Barley (f. sp. ) claim 9 , Powdery Mildew of Cucurbits () claim 9 , Anthracnose of Cucurbits () claim 9 , Leaf Spot of Beet () claim 9 , Early Blight of Tomato () claim 9 , and Net Blotch of Barley ().12Septoria triticiPuccinia triticinaPhakopsora pachyrhizi. The composition according to wherein the fungal pathogen is ...

MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. The compound according to claim 1 , wherein X and Y are hydrogen.3. The compound according to claim 2 , wherein Ris alkyl or aryl claim 2 , each optionally substituted with 0 claim 2 , 1 or multiple R.4. The compound according to claim 2 , wherein Ris hydrogen or alkyl claim 2 , each optionally substituted with 0 claim 2 , 1 or multiple R.5. The compound according to claim 1 , wherein X is C(O)Rand Y is hydrogen.6. The compound according to claim 5 , wherein Ris alkyl or aryl claim 5 , each optionally substituted with 0 claim 5 , 1 or multiple R.7. The compound according to claim 5 , wherein Ris hydrogen or alkyl claim 5 , each optionally substituted with 0 claim 5 , 1 or multiple R.8. The compound according to claim 1 , wherein X is hydrogen and Y is Q.9. The compound according to claim 8 , wherein Ris alkyl or aryl claim 8 , each optionally substituted with 0 claim 8 , 1 or multiple R.10. The compound according to claim 8 , wherein Ris hydrogen or alkyl claim 8 , each optionally substituted with 0 claim 8 , 1 or multiple R.11. The compound according to claim 9 , wherein Ris hydrogen.12. The compound according to claim 9 , wherein Ris —C(O)R or —CHOC(O)R.13. The compound according to claim 12 , wherein Ris alkyl or alkoxy claim 12 , each optionally substituted with 0 claim 12 , 1 claim 12 , or multiple R.14. The compound according to claim 13 , wherein Ris —CH claim 13 , —CH(CH) claim 13 , —CHOCHCH claim 13 , or —CHCHOCH.15. A composition for the control of a fungal pathogen including at least one of the compounds of Formula I and at least one additional compound selected from the group consisting of: a phytologically acceptable carrier material claim 13 , a second fungicide claim 13 , an insecticide claim 13 , a nematocide claim 13 , a miticide claim 13 , an arthropodicide claim 13 , and a bactericide.16. The composition according to claim 15 , wherein the least one ...

BROMINE-SENSITIZED SOLAR PHOTOLYSIS OF CARBON DIOXIDE

There is described a process for depositing carbon on a surface, comprising, while contacting a mixture of COand Brwith a polar substrate presenting apposed surfaces, exposing a sufficient area of said mixture in the region of said apposed surfaces to light of sufficient intensity and frequency to result in deposition of carbon on at least some of said apposed surfaces. Other embodiments are also described. 119-. (canceled)20. A composition of matter comprising a polar substrate presenting apposed surfaces and a mixture of COand Brin contact with at least some of said apposed surfaces.21. A composition of matter according to claim 20 , wherein said polar substrate is a non-carbonaceous polar substrate.22. A composition of matter according to claim 21 , wherein said polar substrate is selected from the group consisting of silica claim 21 , silica-based glasses claim 21 , alumina and titania claim 21 , and mixtures thereof.23. A composition of matter according to claim 22 , wherein said polar substrate is in particulate form.24. A composition of matter according to claim 22 , wherein said polar substrate is selected from sand claim 22 , silica gel claim 22 , powdered alumina claim 22 , titania claim 22 , quartz sand claim 22 , glass spheres claim 22 , and glass wool.25. A composition of matter according to claim 20 , wherein the polar substrate claim 20 , COand Brand are contained in a UV and visible-light transparent region of a reaction vessel.26. A composition of matter according to claim 25 , wherein said UV and visible-light transparent region is transparent to light having a wavelength of 300 to 500 nm.27. A composition of matter according to claim 25 , wherein said UV-light transparent region is also transparent to visible light.28. A composition of matter according to any of wherein the reaction vessel is made from quartz or borosilicate glass.2937-. (canceled)38. A reactor for utilizing solar energy and bromine to reduce CO claim 25 , the reactor comprising a ...

LIGHT GENERATING MICROCAPSULES FOR SELF-HEALING POLYMER APPLICATIONS

A self-healing polymeric material includes a polymeric matrix material, wherein dispersed within the polymeric matrix material is a mixture of materials that includes monomers and a photoinitiator, and a plurality of light generating microcapsules dispersed in the polymeric matrix material. Each light generating microcapsule encapsulates multiple reactants that undergo a chemiluminescent reaction. The chemiluminescent reaction generates a photon having a wavelength within a particular emission range that is consistent with an absorption range of the photoinitiator. 1. A self-healing polymeric material comprising:a polymeric matrix material;wherein dispersed within the polymeric matrix material is a mixture of materials that includes monomers and a photoinitiator; anda plurality of light generating microcapsules dispersed in the polymeric matrix material, each light generating microcapsule of the plurality of light generating microcapsules encapsulating multiple reactants that undergo a chemiluminescent reaction, wherein each light generating microcapsule comprises an outer shell and an inner shell,wherein the chemiluminescent reaction generates a photon having a wavelength within a particular emission range that is consistent with an absorption range of the photoinitiator and wherein the chemiluminescent reaction occurs without rupture of the outer shell of the light generating microcapsules.2. The self-healing polymeric material of claim 1 , wherein a crack in the polymeric matrix material causes migration of the monomers and photoinitiator into the crack.3. The self-healing polymeric material of claim 2 , wherein further propagation of the crack in the polymeric matrix material results in application of a compressive force to a light generating microcapsule of the plurality of light generating microcapsules claim 2 , the compressive force triggering the chemiluminescent reaction within the light generating microcapsule.4. The self-healing polymeric material of ...

Flash and Glow 1,2-Dioxetanes

Compounds having chemiluminescent flash and glow properties. Also disclosed are methods using the compounds to generate light, detect and/or quantify enzymes, antigens, and/or nucleic acids. Also disclosed are kits relating to these compounds. 193.-. (canceled)951. The compound of claim , wherein the cleavage of the bond cleavable by an enzyme moiety results in the generation of light at 37° C. which reaches a maximum in less than about 5 minutes.961. The compound of claim , wherein the cleavage of the bond cleavable by an enzyme moiety results in the generation of light at 37° C. which reaches a maximum in 3 minutes or less.100. A method for generating light , comprising the steps of:{'b': '1', '(a) providing a compound of claim ;'}(b) providing an enzyme complex comprising an enzyme moiety which is capable of cleaving the compound;(c) contacting the enzyme complex with the compound to form a reaction mixture; and,(d) allowing the reaction mixture to generate light.101. The method of claim 100 , wherein the cleavage of the bond cleavable by the enzyme moiety results in the generation of light at 37° C. which reaches a maximum in 3 minutes or less.105. The method of claim 100 , wherein the compound has a constant signal-to-noise ratio.106. The method of claim 100 , wherein the compound has improved sensitivity claim 100 , wherein sensitivity is defined as the lowest amount of hIL-6 detect at a signal-to-noise of 2.107. The method of claim 100 , wherein the enzyme moiety is a hydrolytic enzyme chosen from alkaline phosphatase claim 100 , β-galactosidase claim 100 , β-glucosidase claim 100 , β-glucuronidase claim 100 , or neuraminidase.108. A method for determining the presence and/or amount of an enzyme in a sample claim 100 , comprising the steps of:{'b': '1', '(a) providing a compound of claim ;'}(b) providing a sample suspected of comprising the enzyme which is capable of cleaving the compound so that it decomposes and generates light;(c) contacting the sample ...

Macrocyclic picolinamides as fungicides

This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. 2. A compound according to claim 1 , wherein X and Y are hydrogen.3. A compound according to claim 2 , wherein Ris alkyl claim 2 , aryl claim 2 , or acyl each optionally substituted with 0 claim 2 , 1 or multiple R.4. A compound according to claim 2 , wherein Ris chosen from —(CH)Rwhere n is an integer between 0 and 4 and Ris hydrogen or alkyl claim 2 , optionally substituted with 0 claim 2 , 1 or multiple R.5. A compound according to claim 1 , wherein X is C(O)Rand Y is hydrogen.6. A compound according to claim 5 , wherein Ris chosen from hydrogen claim 5 , alkyl claim 5 , aryl claim 5 , acyl claim 5 , or silyl each optionally substituted with 0 claim 5 , 1 or multiple R.7. A compound according to claim 5 , wherein Ris chosen from —(CH)Rwhere n is an integer between 0 and 4 and Ris hydrogen or alkyl claim 5 , optionally substituted with 0 claim 5 , 1 or multiple R.8. A compound according to claim 1 , wherein X is hydrogen and Y is Q.9. A compound according to claim 8 , wherein Ris chosen from alkyl claim 8 , aryl claim 8 , or acyl each optionally substituted with 0 claim 8 , 1 or multiple R.10. A compound according to claim 8 , wherein Ris chosen from —(CH)Rwhere n is an integer between 0 and 4 and Ris hydrogen or alkyl claim 8 , optionally substituted with 0 claim 8 , 1 or multiple R.11. A compound according to and claim 8 , wherein Ris hydrogen.12. A compound according to and claim 8 , wherein Ris —C(O)Ror —CHOC(O)R.13. A compound according to claim 12 , wherein Ris chosen from alkyl or alkoxy claim 12 , each optionally substituted with 0 claim 12 , 1 claim 12 , or multiple R.14. A compound according to claim 13 , wherein Ris chosen from —CHor —CH(CH).15. A composition for the control of a fungal pathogen including at least one of the compounds of - and a phytologically acceptable carrier material.16. A composition for the control of a fungal pathogen including mixtures ...

CHEMILUMINESCENT METHODS AND REAGENTS FOR ANALYTE DETECTION

The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current invention relates to use chemiluminescent enzyme coupled with analyte binding molecules to detect specific analyte molecules in a homogenous phase. 2. A method to detecting analyte in a sample , comprising:a) contacting said sample with a first ligand of the analyte coupled with ATP producing enzyme and a second ligand of the analyte coupled with luciferase, wherein said luciferase use ATP as substrate; andb) detecting the light generated from said luciferase.3. A kit for detecting analyte in a sample , comprising a first ligand of the analyte coupled with ATP producing enzyme and a second ligand of the analyte coupled with luciferase. This application is the divisional application of U.S. application Ser. No. 12/287,916 filed on Oct. 15, 2008, which claims priority to U.S. Provisional Application No. 60/999,166 filed on Oct. 16, 2007. The entire disclosure of the prior application is considered to be part of the disclosure of the instant application and is hereby incorporated by reference.The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current invention relates to using chemiluminescent enzyme coupled with analyte binding molecules to detect specific analyte molecules in a homogenous phase.Advances in the biological, biomedical and pharmaceutical sciences have accelerated the pace of research and diagnostics to a level unparalleled to the past. With sequences of whole ...

Chiral Cyclodecynes and Methods

Provided herein are cyclodecynes, including chiral cyclodecynes, and methods of making cyclodecynes. The methods may include providing a 1,1′-biaryl compound substituted independently at the 2-position and the 2′-position with a hydroxyl or an amino group; and contacting the 1,1′-biaryl compound with a protected but-2-yne-1,4-diol to form the cyclodecyne. 1. A method of making a cyclodecyne , the method comprising:providing a 1,1′-biaryl compound substituted independently at the 2-position and the 2′-position with a hydroxyl or an amino group; andcontacting the 1,1′-biaryl compound with a protected but-2-yne-1,4-diol to form the cyclodecyne;wherein the amino group comprises a primary amine, a secondary amine, or a tertiary amine.6. The method of claim 1 , wherein the protected but-2-yne-1 claim 1 ,4-diol comprises tosylate protecting groups.7. The method of claim 1 , wherein the protected but-2-yne-1 claim 1 ,4-diol comprises nosylate protecting groups.8. The method of claim 1 , wherein the contacting occurs at ambient temperature and ambient pressure.9. The method of claim 1 , wherein the contacting occurs in the presence of a base.10. The method of claim 9 , wherein the base comprises CsCO.11. The method of claim 1 , wherein the contacting occurs in the presence of CsCO claim 1 , CHCN claim 1 , dimethyl formamide claim 1 , or a combination thereof.12. The method of claim 1 , wherein the cyclodecyne is an (R)-cyclodecyne.13. The method of claim 1 , wherein the cyclodecyne is an (S)-cyclodecyne. This application claims priority to U.S. Provisional Patent Application No. 62/524,743, filed Jun. 26, 2017, which is incorporated herein by reference.Click chemistry has the potential to achieve functional group orthogonality, high yields, and/or other advantages in diverse applications, ranging from surface functionalization to drug delivery. However, the utility of a prototypical click reaction, the Cu-catalyzed alkyne-azide cycloaddition, can be hampered by the toxicity ...

LIGHT GENERATING MICROCAPSULES FOR SELF-HEALING POLYMER APPLICATIONS

A self-healing polymeric material includes a polymeric matrix material, a plurality of monomer mixture microcapsules dispersed in the polymeric matrix material, and a plurality of light generating microcapsules dispersed in the polymeric matrix material. Each monomer mixture microcapsule encapsulates a mixture of materials that includes monomers and a photoinitiator. Each light generating microcapsule encapsulates multiple reactants that undergo a chemiluminescent reaction. The chemiluminescent reaction generates a photon having a wavelength within a particular emission range that is consistent with an absorption range of the photoinitiator. 110.-. (canceled)11. A process of utilizing chemiluminescence for polymeric self-healing , the process comprising:dispersing a monomer mixture microcapsule in a polymeric matrix material, the monomer mixture microcapsule encapsulating a mixture of materials that includes monomers and a photoinitiator; anddispersing a light generating microcapsule in the polymeric matrix material, the light generating microcapsule encapsulating multiple reactants that undergo a chemiluminescent reaction, wherein the chemiluminescent reaction generates a photon having a wavelength within a particular emission range that is consistent with an absorption range of the photoinitiator,wherein the monomer mixture microcapsule is adapted to rupture to cause migration of the mixture of materials into a crack in the polymeric matrix material, andwherein the light generating microcapsule is adapted to cause the multiple reactants to undergo the chemiluminescent reaction within the light generating microcapsule in response to application of a compressive force.12. The process of claim 11 , wherein the chemiluminescent reaction includes excitation of a dye from a ground state to an excited state and subsequent release of the photon upon relaxation from the excited state to the ground state.13. The process of claim 11 , wherein the light generating ...

Chiral compounds

LCD display

New diphosphine compound, intermediates for their preparation, transition metal complex containing the compound as ligand and catalyst for asymmetric hydrogenations containing the complex

一种环状化合物及其制备方法和应用

本发明涉及一种式I所示的环状化合物及其制备方法和应用。本发明所述的环状化合物用于作为内给电子体化合物，可得到综合性能优良的烯烃聚合催化剂。特别是用于丙烯聚合时，催化剂的氢调敏感性好，所得聚合物的等规指数可调，所得聚丙烯树脂分子量分布宽。

Acetal-based compositions

An acetal-based composition useful as a nucleating, gelling, thickening or clarifying agent is disclosed. The composition may be synthesized or provided in many different forms, including multicarbon diacetals formed from carbohydrates. Once synthesized, the compound may be employed as an additive in a plastic composition, such as (for example) a polypropylene copolymer. One structure of such an acetal-based composition is provided by the formula: wherein: n is 0, 1 or 2; Ar 1 and Ar 2 are independently selected from substituted or unsubstituted aryl-containing groups; and R is selected from the group consisting of: alkenyls, alkyls, alkoxy, hydroxyl alkyls, and alkyl-halides.

Method of polyolefin composition nucleation by acetal compounds

FIELD: chemistry. SUBSTANCE: invention concerns method of polyolefin composition nucleation by mixing the composition with compound of the structural formula: , where: n is 0, 1 or 2; Ar 1 and Ar 2 are independently selected out of group including non-substituted aryl groups and aryl groups substituted by substitutes selected out of group including alkyl groups, alkenyl groups, alkinyl groups, alkoxy groups, carboxy groups and halogens; and R is selected out of group including alkenyl groups, alkyl groups, alkoxy groups, hydroxyalkyl groups and alkylhalide groups. Also invention claims the compound itself, method of its obtaining and moulded or cast polyolefin article including this compound. EFFECT: efficient method of polyolefin composition nucleation. 19 cl, 3 tbl, 22 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 348 637 (13) C2 (51) ÌÏÊ C07D 493/04 (2006.01) C08K 5/1575 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2006141650/04, 05.04.2005 (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 05.04.2005 (30) Êîíâåíöèîííûé ïðèîðèòåò: 26.04.2004 US 10/831,920 16.07.2004 US 10/893,633 (43) Äàòà ïóáëèêàöèè çà âêè: 10.06.2008 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: US 597043 À, 26.10.1999. US 5049605 À, 17.09.1991. US 4314039 À, 02.02.1982. RU 2203898 Ñ2, 20.10.2000. (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 27.11.2006 2 3 4 8 6 3 7 R U (87) Ïóáëèêàöè PCT: WO 2005/111134 (24.11.2005) C 2 C 2 (86) Çà âêà PCT: US 2005/011686 (05.04.2005) Àäðåñ äë ïåðåïèñêè: 129090, Ìîñêâà, óë. Á.Ñïàññêà , 25, ñòð.3, ÎÎÎ "Þðèäè÷åñêà ôèðìà Ãîðîäèññêèé è Ïàðòíåðû", ïàò.ïîâ. Å.Å.Íàçèíîé (54) ÑÏÎÑÎÁ ÍÓÊËÅÀÖÈÈ ÏÎËÈÎËÅÔÈÍÎÂÎÉ ÊÎÌÏÎÇÈÖÈÈ ÀÖÅÒÀËÜÍÛÌÈ ÑÎÅÄÈÍÅÍÈßÌÈ (57) Ðåôåðàò: Äàííîå èçîáðåòåíèå îòíîñèòñ ê ñïîñîáó íóêëåàöèè ïîëèîëåôèíîâîé êîìïîçèöèè ïóòåì ñìåøåíè ýòîé êîìïîçèöèè ñ ñîåäèíåíèåì, èìåþùèì ñòðóêòóðó ôîðìóëû: ãäå: n ðàâíî 0, 1 èëè 2; Ar1 è Ar2 íåçàâèñèìî âûáðàíû èç ...

1,2,4- Trioxepanes as precursors for lactones

The present invention pertains to a novel process for the preparation of lactones by decomposition of a 1,2,4-trioxepane of formula (I) wherein, R is H or CH 3 , n is 1-14, Rx independently is any substituent on the ring structure, including substituents which form bi- or tricyclic structures, and m is 0-34.

Macrocyclic picolinamides as fungicides

The present disclosure relates to macrocyclic picolinamides and their use as fungicides. The compounds of the present disclosure may offer protection against ascomycetes, basidiomycetes, deuteromycetes and oomycetes. The present disclosure presents a method for the control or prevention of fungal attack on a plant, the method including the steps of applying a fungicidally effective amount of one or more of the compounds described to at least one of the fungus, the plant, and an area adjacent to the plant.

1,2,4,-trioxepanes as precursors for lactones

The present invention pertains to a novel process for the preparation of lactones by decomposition of a 1,2,4-­trioxepane of formula (I) wherein, R is H or CH3, n is 1-14, Rx independently is any substituent on the ring structure, including substituents which form bi- or tricyclic structures, and m is 0-34.

Synthesis and use of isotopically labeled macrocyclic compounds

Disclosed herein are isotopically labeled antifungal antibiotics and related compounds. Also disclosed are methods for synthesizing these isotopically labeled molecules and using the same to study the distribution of these compounds in the biosphere as well as the products formed by the breakdown of these isotopically labeled compounds.

Macrocyclic picolinamides as fungicides

This disclosure relates to macrocyclic picolinamides of Formula (I) described herein, wherein X, Y, R1 and R2 are as defined herein and to their use as fungicides in a formulation comprising a phytologically acceptable carrier. Also provided are methods of using compounds of Formula (I) in combination with other pesticides including fungicides, insecticides, nematocides, miticides, arthropodicides, bactericides, and combinations thereof.

Macrocyclic picolinamides as fungicides

本發明係關於式I之巨環吡啶醯胺及其作為殺真菌劑之用途。 □

Macrocyclic picolinamides as fungicides

Macrocyclic picolinamides as fungicides

Cyclic micro-crosslinkable polycarboxylic acid polymerization intermediate, preparation method thereof and polycarboxylic acid water reducing agent

本发明涉及混凝土外加剂技术领域，具体公开了一种环状可微交联聚羧酸聚合中间体的制备方法，包括以下步骤：将多元醇及有机溶剂加入反应器中，搅拌均匀后加入缚酸剂，通入氮气保护，在0~5℃条件下，滴加不饱和酰氯反应1~8h，用饱和盐溶液进行萃取得到萃取物，然后将萃取物减压蒸馏蒸发有机溶剂，得到环状可微交联聚羧酸聚合中间体。本发明利用多元醇与不饱和酰氯直接高效酯化得到环状可微交联聚羧酸聚合中间体，将制得中间体应用于羧酸聚合，得到带环状结构且分子链微交联的聚羧酸减水剂，降低羧酸对泥土的敏感性，提高聚羧酸减水剂的保水性，增强对水泥的分散能力，降低对水的敏感度，提高抗离析泌水性能。

Methods for generating light with chemiluminescent dioxetanes activated by anchimeric assisted cleavage

Novel assay methods employing compounds which are chemically or enzymatically cleavable and which give rise to an intermediate which further decomposes by an intramolecular anchimeric displacement reaction which releases a signal producing species are disclosed. Also disclosed are probe hybridization assays employing the compounds of the invention employing thermostable enzymes which are not denatured by the hybridization conditions. Such signal producing species may include chemiluminescent dioxetanes and other colored products.

Liquid crystal display

Liquid-crystal display

本发明涉及PSA(聚合物支持的配向)型液晶显示器，和用于PSA显示器的新型液晶介质和新型可聚合化合物。

Functionalised oxacalixarenes, their preparation and use in instant adhesive compositions

Oxacalixarenes of general formula I:- wherein m = 0 - 7 and n = 1 - 8 with the proviso that m + n

Liquid-crystal display

本发明涉及PSA(聚合物支持的配向)型液晶显示器，和用于PSA显示器的新型液晶介质和新型可聚合化合物。

Method of nucleating a polyolefin composition with acetal-based compounds

본 발명은 핵 형성제, 겔화제, 증점제 또는 청징제로서 유용한 아세탈계 조성물에 관한 것이다. 조성물은 탄수화물로부터 제조되는 다탄소 다이아세탈을 비롯한 다수의 상이한 형태로 합성 또는 제공될 수 있다. 합성 후, 화합물을 (예컨대) 폴리프로필렌 공중합체 같은 플라스틱 조성물의 첨가제로서 사용할 수 있다. 보조-첨가제도 사용할 수 있다. 몇 가지 아릴 구조가 탄화수소 쇄 주쇄에 존재할 수 있다. 이러한 아세탈계 조성물의 한 구조는 쇄의 말단 탄소상의 하나 이상의 아릴기 및 하나 이상의 치환된 기로 개질된 솔비톨이다. The present invention relates to acetal based compositions useful as nucleating agents, gelling agents, thickeners or clarifiers. The composition can be synthesized or provided in a number of different forms, including multicarbon diacetals made from carbohydrates. After synthesis, the compounds can be used as additives in plastic compositions such as (eg) polypropylene copolymers. Co-additives may also be used. Several aryl structures may be present in the hydrocarbon chain backbone. One structure of such acetal-based compositions is sorbitol modified with one or more aryl groups and one or more substituted groups on the terminal carbon of the chain.

Method of obtaining c2-c4 alkylencarbonate

Alkylene carbonates, particularly ethylene carbonate, are prepared by the reaction of an alkylene oxide with carbon dioxide in the presence of a catalyst at temperatures ranging upwards from 20 DEG C, particularly temperatures above about 90 DEG C, preferably 90-170 DEG C. The conversion of alkylene oxide to alkylene carbonate can be carried out in the presence of water while minimizing the undesirable hydrolysis of the carbonate to the corresponding alkylene glycol and formation of higher glycols. This is achieved by maintaining the water to alkylene oxide molar ratio and the carbon dioxide to alkylene oxide ratio within stated limits and adjusting the carbon dioxide partial pressure to provide the desired selectivity to alkylene carbonate.

A kind of preparation method of sofalcone known impurities

本发明公开了一种治疗胃溃疡药物索法酮原料药中已知杂质的制备方法。本发明提供了一种以索法酮为原料，通过光催化[2+2]环加成反应、柱层析、重结晶方法得到该杂质纯品。本发明具有合成简便，对反应的转化率要求不高的特点，所得产品纯度高，可以为索法酮的质量控制提供合格的杂质对照品。

Process for the preparation of macrocyclic esters

Verfahren zur Herstellung makrocyclischer Esterverbindungen der Formel worin x und y in Summe eine Zahl von mindestens 10 und höchstens 13 ergeben; A eine Methylengruppe oder ein Heteroatom wie Sauerstoff oder Schwefel bedeuten kann; B eine Methylengruppe oder eine Carbonylgruppe bedeuten kann oder A und B zusammengenommen eine Kohlenstoffdoppelbindung bedeuten können; durch Kondensation von difunktionellen Verbindungen der Formel worin x und y in Summe eine Zahl von mindestens 10 und höchstens 13 ergeben; A eine Methylengruppe oder ein Heteroatom wie Sauerstoff oder Schwefel bedeuten kann; B eine Methylengruppe bedeuten kann oder A und B zusammengenommen eine Kohlenstoffdoppelbindung bedeuten können; R 1 ein Wasserstoffatom, Methyl oder Ethyl bedeuten kann; oder der Formel worin x und y in Summe eine Zahl von mindestens 10 und höchstens 13 ergeben; R 1 ein Wasserstoffatom, Methyl oder Ethyl bedeuten kann; ... Process for the preparation of macrocyclic ester compounds of the formula wherein x and y add up to a number of at least 10 and at most 13; A can represent a methylene group or a hetero atom such as oxygen or sulfur; B may represent a methylene group or a carbonyl group or A and B taken together can represent a carbon double bond; by condensation of difunctional compounds of the formula wherein x and y add up to a number of at least 10 and at most 13; A can represent a methylene group or a hetero atom such as oxygen or sulfur; B may represent a methylene group or A and B taken together may represent a carbon double bond; R 1 can represent a hydrogen atom, methyl or ethyl; or the formula wherein x and y add up to a number of at least 10 and at most 13; R 1 can represent a hydrogen atom, methyl or ethyl; ...

Process for the production of cyclic diesters of dodecanedioic acid

Cyclic esters of dodecanedioic acid with aliphatic diols of 2-12 carbon atoms in the chain and substituted by up to two alkyl of 1-4 carbon atoms, are produced by thermolysis of corresponding linear polyesters under reduced pressure in the presence of catalysts by subjecting the linear polyesters to thermolysis at temperatures between 200° and 300° C., and by utilizing as catalyst a tin(II) salt of an aliphatic monocarboxylic acid of up to 18 carbon atoms, of an aromatic or araliphatic monocarboxylic acid of up to 36 carbon atoms, of an aliphatic or aromatic hydroxy-, poly-, ketocarboxylic acid or of a dicarboxylic acid of up to 18 carbon atoms; or a mixture of an organotin compound of the formula ##STR1## wherein R 1 and R 2 are alkyl of 1-18 carbon atoms, or aryl or aralkyl of 6-36 carbon atoms, and an O,O-dialkyl-(3,5-di-tert.-butyl-4-hydroxybenzyl)-phosphonate wherein each alkyl is of 2-18 carbon atoms.

Process for the production of cyclic diesters of dodecanedioic acid

Cyclic esters of dodecanedioic acid with aliphatic diols of 2-12 carbon atoms in the chain and substituted by up to two alkyl of 1-4 carbon atoms, are produced by thermolysis of corresponding linear polyesters under reduced pressure in the presence of catalysts by subjecting the linear polyesters to thermolysis at temperatures between 200° and 300° C., and by utilizing as catalyst a tin(II) salt of an aliphatic monocarboxylic acid of up to 18 carbon atoms, of an aromatic or araliphatic monocarboxylic acid of up to 36 carbon atoms, of an aliphatic or aromatic hydroxy-, poly-, ketocarboxylic acid or of a dicarboxylic acid of up to 18 carbon atoms; or a mixture of an organotin compound of the formula ##STR1## wherein R 1 and R 2 are alkyl of 1-18 carbon atoms, or aryl or aralkyl of 6-36 carbon atoms, and an O,O-dialkyl-(3,5-di-tert.-butyl-4-hydroxybenzyl)-phosphonate wherein each alkyl is of 2-18 carbon atoms.

Advanced processes for the preparation of nitroacetates and nitrocetones

PROCESS FOR PREPARING CYCLIC ESTERS OF UNDECANEDIOIC ACID

L'invention est relative à un procédé de préparation d'esters cycliques de l'acide undécanedioïque. Selon le procédé, on thermolyse les polyesters linéaires à des températures de 200 à 300 degrés C, et que l'on utilise comme catalyseurs des composés organiques de l'étain répondant à la formule : The invention relates to a process for the preparation of cyclic esters of undecanedioic acid. According to the process, linear polyesters are thermolysed at temperatures of 200 to 300 degrees C, and which are used as catalysts organic tin compounds of the formula:

Composition and method for disinfecting and sterilizing material contaminated with bacteria, fungi, spores, viruses and the like.

Patent FR2385712B1

PROCESS FOR THE CATALYTIC PREPARATION OF ALKYLENE CARBONATES

PROCESS FOR THE PRODUCTION OF HETERO-MACROCYCLIC COMPOUNDS

L'invention concerne un procédé de production continu ou semi-continu de composés hétéro-macrocycliques comprenant des lactones et des esters cycliques. Le procédé comprend la dépolymérisation catalysée d'un polyester linéaire à une température élevée et sous pression réduite en présence d'une quantité spécifiée de monocarboxylates, tout en fournissant un brassage de haut en bas dans pratiquement tout le volume de la masse réactionnelle. Application à la production de composés hétérocycliques utilises comme agents parfumants. The invention relates to a process for the continuous or semi-continuous production of hetero-macrocyclic compounds comprising lactones and cyclic esters. The process comprises the catalyzed depolymerization of a linear polyester at elevated temperature and under reduced pressure in the presence of a specified amount of monocarboxylates, while providing top-to-bottom mixing throughout substantially the entire volume of the reaction mass. Application to the production of heterocyclic compounds used as perfuming agents.

Process for the production of a macrocyclic ester compound.

According to the invention glycol or an oligoester is added to a reaction system containing a linear ester at an optional stage of the reaction to obtain the macrocyclic ester compound. The invention applies especially to the production of musk perfume.

1,2-DIOXETANE COMPOUNDS, THEIR PREPARATION AND THEIR USE FOR DETERMINING THIOLS AND ACETYLCHOLINESTERASE

PROCESS FOR PREPARING CYCLIC DIESTERS FROM DODECANE-DIOIC ACID

Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes

Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically cleavable labile subsituent thereof is intentionally cleaved, are disclosed. These compounds can he represented by formula (I) wherein X and X1 each represent. individually, hydrogen, a hydroxyl group, a halo substituent, an unsubstituted lower alkyl group, a hydroxy (lower) alkyl group, a halo (lower) alkyl group, a phenyl group, a halophenyl group, an alkoxyphenyl group, a hydroxyalkoxy group. a cyano group, a carboxyl or substituted carboxyl group or an amide group, with at least one of X and X1 being other than hydrogen; and R1 and R2 individually or together, represent an organic substituent that does not interfere with the production of light when the dioxetane compound is enzymatically cleaved and that satisfies the valence of the dioxetane compound's 4-carbon atom, with the provisos that if R1 and R2 represent individual substituents the R2 substituent is aromatic, heteroaromatic, or an unsaturated substituent in conjugation with an aromatic ring, and that at least one of R1 and R2 is, or R1 and R2 taken together are, an enzymatically cleavable labile group-substituted fluorescent chromophore group that produces a luminescent substance when the enzymatically cleavable labile substituent thereof is removed by an enzyme. The corresponding dioxetanes which, instead of being substituted at the 5' or 7', or at the 5' and ~ positions, instead contain a 4' methylene group, are also disclosed, as are intermediates for all these 3substituted adamant-2'-ylidenedioxetanes, and their use as reporter molecules in assays.

Hydroxyalkyl esters of brassylic acid

Cyclic dicarboxylic esters of formula H2nCn(CO2)2 CmH2m or X(O(CH2)y)2(CO)2CmH2m (where n and m are 2-17, y is 1-4 and X is an aromatic carbocyclic ring) are made by heating dialkyl esters of dicarboxylic acids with a diol of formula HOCmH2m at up to 200 degrees C in a high boiling paraffin in presence of a catalyst such as dibutyl-Sn-dilaurate. The mixt. is then distilled at 200 degrees- 325 degrees C under reduced pressure and the product is recovered from the distillate.

Patent FR2328704B1

BIOMARKER WITH LUMINESCENT TRANSMISSION

Composition and method for disinfecting and sterilizing material contaminated with bacteria, fungi, spores, viruses and the like.

On décrit un procédé et une composition pour désinfecter une substance ou des matières, telles que des instruments médicaux, des salles d'opération, des tables d'examen, des murs, des fenêtres, des sols, des solutions, des substances poreuses et similaires, contaminées par des bactéries, des spores bactériennes, des champignons ou des virus. La composition consiste en un mélange d'un peroxymonosulfate et d'un composé à teneur en carbonyle et de leurs produits de réaction, et est, de préférence, un dioxiranne formé par oxydation in situ d'une cétone ou d'un aldéhyde par le peroxymonosulfate en solution aqueuse. Les composés à teneur en carbonyle qui ont été testés comprennent l'acétone, la 2-pentanone, la 4-hydroxy-4-méthyl-2-pentanone et l'acide camphre sulfonique. Le procédé comprend les opérations consistant à prendre une solution contenant le mélange réactionnel de dioxiranne et de mettre en contact la substance ou les matières avec elle à la température ambiante pendant un laps de temps suffisant pour désinfecter et stériliser la substance ou les matières. A method and composition is described for disinfecting a substance or materials, such as medical instruments, operating rooms, examination tables, walls, windows, floors, solutions, porous substances, and the like. , contaminated with bacteria, bacterial spores, fungi or viruses. The composition consists of a mixture of a peroxymonosulfate and a carbonyl-containing compound and their reaction products, and is preferably a dioxirane formed by in situ oxidation of a ketone or an aldehyde by the peroxymonosulfate in aqueous solution. Carbonyl compounds that have been tested include acetone, 2-pentanone, 4-hydroxy-4-methyl-2-pentanone and camphor sulfonic acid. The method includes the steps of taking a solution containing the dioxirane reaction mixture and contacting the substance or materials with it at room temperature for a period of time sufficient to disinfect and sterilize the ...

Patent FR2404007B1

Antibiotics produced by Cytospora sp. W.F.P.L. 13A

When Cytospora sp. is subjected to aerobic fermentation a number of new antibiotics are produced. Methods of production, recovery and purification of these antibiotics are described and some of their antimicrobial properties are described. One of the new antibiotics discovered (Grahamimycin A) corresponds to the formula: ##STR1## Another (Grahamimycin B) corresponds to the formula: ##STR2##

Dioxetane labeled probes and detection assays employing the same

Probes labeled with 1,2-dioxetane precursors can be employed in a variety of assays. The probes may be nucleic acid, peptide nucleic acid, proteins including enzyme, antibody or antigen, steroid, carbohydrate, drug or non-drug hapten. The probe is provided with a 1,2-dioxetane precursor bound thereto, generally either covalently, or a strong ligand bond. The dioxetane precursor moiety is converted to a bound 1,2-dioxetane by exposure to singlet oxygen. These dioxetane (labels) either spontaneously decompose, or are induced to decompose by an appropriate trigger to release light. The trigger may be a change in pH temperature, or an agent which removes a protective group. Assay formats in which these 1,2-dioxetane labeled probes and referents may be used to include hybridization assays, immuno assays, gel-based assays and Capillary Zone Electrophoresis.

Method of manufacture of alkylene carbonates

Big ring picolinamide as antifungal

本申请涉及式(I)大环吡啶酰胺，其中X，Y，R 1 和R 2 如本申请中限定，以及它们涉及作为杀真菌剂在包含植物学上可接受的载体的制剂中的用途。发现式(I)化合物具有抵抗真菌病原体的活性，所述真菌病原体为以下中的一种：小麦斑枯病(Leaf Blotch of Wheat)(Zymoseptoria tritici)，小麦褐锈病(Wheat Brown Rust)(小麦叶锈菌(Puccinia triticina))，以及大豆锈病(Rust of Soybean)(大豆锈菌(Phakopsora pachyrhizi))。

Dioxetane labeled probes and detection assays employing the same

Probes labeled with 1,2-dioxetane precursors can be employed in a variety of assays. The probes may be nucleic acid, peptide nucleic acid, proteins including enzyme, antibody or antigen, steroid, carbohydrate, drug or non-drug hapten. The probe is provided with a 1,2-dioxetane precursor bound thereto, generally either covalently, or a strong ligand bond. The dioxetane precursor moiety is converted to a bound 1,2-dioxetane by exposure to singlet oxygen. The dioxetane (labels) either spontaneously decompose, or are induced to decompose by an appropriate trigger to release light. The trigger may be a change in pH temperature, or an agent which removes a protective group. Assay formats in which these 1,2-dioxetane labeled probes and referents may be used to include hybridization assays, immuno assays, gel-based assays and Capillary Zone Electrophoresis.

1,2 chemiluminescent dioxetanes of improved performance.

Una clase nueva de dioxetanos estables porta un grupo estabilizante policíclico y una porcion ariloxi, el átomo de oxígeno del cual que es proporcionado con un grupo protector el cual puede ser eliminado por un activador enzimático o químico mezclado con el dioxetano. El grupo estabilizante policíclico es preferiblemente espiroadamantano. El grupo tiene una porcion alcoxi, ariloxi, aralquiloxi o cicloalquiloxi la cual es substituida parcial o totalmente con halogenos, particularmente fluor y cloro. La seleccion apropiada de los grupos activos a electrones sobre la porcion estabilizante, el grupo arilo y el grupo OR produce cinéticas enzimáticas mejoradas, intensidad de luz superior y sensibilidad de deteccion excelente en varios ensayos.

Liquid-crystal display

본 발명은 PSA(polymer sustained alignment; 중합체 지속 배향) 유형의 액정 디스플레이, 및 PSA 디스플레이에 사용하기 위한 신규 액정 매질 및 신규의 중합가능한 화합물에 관한 것이다. PSA 디스플레이, 액정 매질, 바이아릴 화합물.

Process for the preparation of 1,2-dioxetane compounds and novel sulfur-substituted 1,2-dioxetane compounds as intermediates

A process is provided for the preparation of a variety of triggerable dioxetanes bearing alkoxy, alkenyloxy, alkynyloxy, arlyoxy, aralkyloxy or acyloxy substituents from a common intermediate along with sulfur-substituted dioxetanes and vinyl sulfide compounds used as intermediates. Alkoxy, alkenyloxy, alkynyloxy, arlyoxy, aralkyloxy or acyloxy substituted dioxetanes are useful in detecting activating agents and in assays such as immunoassays and nucleic acid hybridization assays. The sulfur-substituted dioxetanes additionally are useful for producing chemiluminescence. The novel process involves conversion of a vinyl sulfide compound to a sulfur-substituted dioxetane, reacting the sulfur-substituted dioxetane with an electrophilic agent and a hydroxylic compound or salt thereof and forming the alkoxy, alkenyloxy, alkynyloxy, arlyoxy, aralkyloxy or acyloxy-substituted dioxetane.

Preparation method of sofalcone known impurity

本发明公开了一种治疗胃溃疡药物索法酮原料药中已知杂质的制备方法。本发明提供了一种以索法酮为原料，通过光催化[2+2]环加成反应、柱层析、重结晶方法得到该杂质纯品。本发明具有合成简便，对反应的转化率要求不高的特点，所得产品纯度高，可以为索法酮的质量控制提供合格的杂质对照品。

Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes

Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically cleavable labile substituent thereof is intentionally cleaved, are disclosed. These compounds can be represented by the formula: ##STR1## wherein: X and X 1 each represent, individually, hydrogen, a hydroxyl group, a halo substituent, an unsubstituted lower alkyl group, a hydroxy (lower) alkyl group, a halo (lower) alkyl group, a phenyl group, a halophenyl group, an alkoxyphenyl group, a hydroxyalkoxy group, a cyano group or an amide group, with at least one of X and X 1 being other than hydrogen; and R 1 and R 2 , individually or together, represent an organic substituent that does not interfere with the production of light when the dioxetane compound is enzymatically cleaved and that satisfies the valence of the dioxetane compound's 4-carbon atom, with the provisos that if R 1 and R 2 represent individual substituents the R 2 substituent is aromatic, heteroaromatic, or an unsaturated substituent in conjugation with an aromatic ring, and that at least one of R 1 and R 2 is, or R 1 and R 2 taken together are, an enzymatically cleavable labile group-substituted fluorescent chromophore group that produces a luminescent substance when the enzymatically cleavable labile substituent thereof is removed by an enzyme. The corresponding dioxetanes which, instead of being substituted at the 5' or 7', or at the 5' and 7' positions, instead contain a 4' methylene group, are also disclosed, as are intermediates for all these 3-substituted adamant-2'-ylidenedioxetanes, and their use as reporter molecules in assays.

Compounds

PROCESS FOR THE PRODUCTION OF HETEROMACROCYL COMPOUNDS

Chemiluminescent double-triggered 1, 2-dioxetanes

A stable 1,2-dioxetane of the formula: ##STR1## wherein X' is a phenyl group with 0 to 2 Cl or I atoms. This 1,2-dioxetane is a double-trigger substrate. The 2-methyl-4-hydroxy-naphthyl group is first removed by horseradish peroxidase. The exposed phosphate group is then removed with alkaline phosphatase. The exposed phenoxy 1,2-dioxetane decomposes to generate chemiluminescence output in immunoassays or nucleic acid hybridization assays.

1,4-DIOXACYCLOALKAN-2-ONE AND 1,4-DIOXACYCLOALKEN-2-ONE

Chemiluminescent 1,2-dioxetanes

Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an enzyme with which the dioxetane is permitted to come in contact with. The T 1/2 kinetics of the chemiluminescent reaction, as well as the signal intensity, or quantum yield of the chemiluminescent reaction, can be altered by selection of an electron-withdrawing or an electron-donating group Z, at positions on the aromatic substituent other than those adjacent the point of attachment to the dioxetane. Signal strength can further be enhanced by recognized chemiluminescent enhancers.

Dioxacycloalkan-8-one

MACROCYCLIC PICOLINAMIDES AS FUNGICIDES

1. Соединение формулы I,где Х представляет собой Н или C(O)R;Y представляет собой Н, C(O)Rили Q;Q представляет собой;Rпредставляет собой О;Rпредставляет собой Н, алкил, алкенил, арил, гетероциклил, силил, замещенные, каждый, 0, 1 или несколькими R, -С(О)R;Rпредставляет собой фенил или циклогексил;Rпредставляет собой алкил или алкокси, замещенный 0, 1 или несколькими R;Rпредставляет собой гидрокси, алкил, алкенил, галоген, галогеналкил, алкокси, галогеналкокси, C(O)R, арилалкокси или арил, где каждый Rзамещен 0, 1 или несколькими R;Rпредставляет собой алкокси, бензилокси, замещенный 0, 1 или несколькими R;Rпредставляет собой Н, -С(О)Rили -СНОС(О)R;Rпредставляет собой гидрокси, алкил, алкокси, N(R)или арилалкокси; иRпредставляет собой Н или алкил.2. Соединение по п. 1, где Х и Y выбирают независимо из Н или C(O)R.3. Соединение по п. 2, где Rвыбирают независимо из Н, алкила, алкенила, арила, гетероциклила, силила, -С(О)R, каждого замещенного 0, 1 или несколькими R.4. Соединение по п. 3, где Rпредставляет собой независимо фенил или циклогексил.5. Соединение по п. 4, где Rпредставляет собой алкил или арил, замещенный 0, 1 или несколькими R.6. Соединение по п. 5, где Rпредставляет собой алкокси или бензилокси, замещенный 0, 1 или несколькими R.7. Соединение по п. 6, где Rпредставляет собой водород или алкил.8. Соединение по п. 1, где Х представляет собой Н, и Y представляет собой Q.9. Соединение по п. 8, где Q представляет собой.10. Соединение по п. 9, где Rвыбирают независимо из алкила, арила или -С(О)R, каждого замещенного 0, 1 или несколькими R.11. Соединение по п. 10, где Rпредставляет собой фенил.12. Соединение по п. 11, где Rпредставляет собой алкил, замещенный 0, 1 или несколькими R.13. Соединение по п. 12, где Rпредставляет собой алкил, арил, алкокси или галоген.14. Композиция для борьбы с патогенным грибом, включающая, по меньшей ме РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07D 405/12 (13) 2014 149 194 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ ...

Chemiluminescent dialkyl-substituted 1,2-dioxetanes, methods of synthesis and use

A chemiluminescent assay method and compositions are described which use a dialkyl-substituted dioxetane which is deprotected to trigger a chemiluminescent reaction. Chemiluminescent 1,2-dioxetane compounds substituted on the dioxetane ring with two nonspirofused alkyl groups which can be triggered by a reagent to generate light are disclosed. Dialkyl-substituted dioxetanes are useful for the detection of triggering agents including enzymes. The enzyme may be present alone or linked to a member of a specific binding pair in an immunoassay, DNA probe assay or other assay where the enzyme is bound to a reporter molecule.

Chemiluminescent energy transfer assays

Chemiluminescent assays for the determination of the presence or amount of a biopolymer in bound assays using 1,2-dioxetanes in connection with AttoPhosTM as chemiluminescent substrates for enzymelabeled targets or probes is provided. Further disclosed is a kit for conducting a bioassay for the presence or concentration of a biopolymer comprising a) an enzyme complex; b) a 1,2-dioxetane; and c) AttoPhosTM.

macrocyclic picolinamides as fungicides

a presente invenção refere-se às picolinamidas macrocíclicas de fórmula (i) aqui descritas, em que x, y, r1 e r2 são como aqui definidos e ao seu uso como fungicidas em uma formulação compreendendo um portador fitologicamente aceitável. também são fornecidos métodos de uso de compostos de fórmula (i) em combinação com outros pesticidas incluindo fungicidas, inseticidas, nematocidas, acaricidas, artropodicidas, bactericidas e suas combinações The present invention relates to macrocyclic picolinamides of formula (I) described herein, wherein x, y, r 1 and r 2 are as defined herein and their use as fungicides in a formulation comprising a phytologically acceptable carrier. Also provided are methods of using compounds of formula (I) in combination with other pesticides including fungicides, insecticides, nematocides, acaricides, arthropodicides, bactericides and combinations thereof.

Cyclic compound and preparation method and application thereof

本发明涉及一种式I所示的环状化合物及其制备方法和应用。本发明所述的环状化合物用于作为内给电子体化合物，可得到综合性能优良的烯烃聚合催化剂。特别是用于丙烯聚合时，催化剂的氢调敏感性好，所得聚合物的等规指数可调，所得聚丙烯树脂分子量分布宽。

Chemiluminescent 1,2-dioxetanes

Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an enzyme with which the dioxetane is permitted to come in contact with. The T 1/2 kinetics of the chemiluminescent reaction, as well as the signal intensity, or quantum yield of the chemiluminescent reaction, can be altered by selection of an electron-withdrawing or an electron-donating group Z, at positions on the aromatic substituent other than those adjacent the point of attachment to the dioxetane. Signal strength can further be enhanced by recognized chemiluminescent enhancers.

Macrocyclic picolinamides as fungicides

This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.

Preparation method of levo-nicotine

本发明提供一种左旋烟碱的制备方法，所述方法可得到光学纯度高达99.9％以上的左旋烟碱，远高于目前市场同类产品，合成的总收率达到50～60％，反应物料廉价易得，操作简单，环境友好，适合大规模的工业化生产。

Chemiluminescent double-triggered 1,2-dioxetanes

A stable 1,2-dioxetane of the formula (I), where R1, R2 and R3 are passive organic groups that allow the dioxetane to decompose and produce light when Z and Y are removed, with the proviso that R1 and R2 may be joined to form a cyclic moiety, Z is a first protecting group that can be removed by a first deprotecting process, Y is a second protecting group that can be removed by a second deprotecting process, and X is an organic group which upon removal of Z and Y renders the dioxetane susceptible to said decomposition, with the proviso that X may be joined to R3 to form a cyclic moiety. These di-oxetanes are useful for generating chemiluminescent output in immunoassays and nucleic acid hybridization assays.

Improved enhancement of chemiluminescent assays

Chemiluminescent bioassays for the presence or concentration of an analyte in a sample use 1,2-dioxetanes as substrates for the enzyme of an enzyme complex that bind to the analyte. The chemiluminescence obtained from the decomposition of the dioxetane trigerred by the enzyme through the formation of the corresponding 1,2-dioxetane oxyanion of the enzyme complex is enhanced by the addition of TBQ as an enhancement agent. Other polymeric quatenary onium salts can be used as enhancements agents in conjunction with enhancement additives which improve the ability of the enhancement agent to form hydrophobic regions in the aqueous sample, in which regions the 1-2-dioxetane oxyanion and its chemiluminescent decomposition products can be sequestered. A kit for performing such assays is also provided.

Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore

PROCESS FOR PRODUCING A MACROCYCLIC ESTER COMPOUND

PREPARATION PROCEDURE OF 1,2-DIOXETHANES THAT PRODUCE QUIMIOLUMINESCENCE BY DOUBLE ACTIVATION

Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates

Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their preparation. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure and an additional fluorine atom or lower alkyl group provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. These dioxetanes display substantially improved stability on storage. Compositions comprising these dioxetanes, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.

Process for preparing alpha, omega di-substituted alkanes

1,206,783. Preparation of α,#-disubstituted alkanes. TECHNI-CHEM CO. 3 Oct., 1967 [10 Oct., 1966; 2 Feb., 1967; 29 May, 1967; 15 Aug., 1967], No. 45033/67. Heading C2C. Compounds of the formula wherein X is an electronegative group selected from -NO 2 and -COOR<SP>1</SP>, where R<SP>1</SP> is a C 1-12 hydrocarbon radical, n is an integer from 2 to 17 when X is -NO 2 or an integer from 7 to 17 when X is -COOR<SP>1</SP>, Z is -OH, -OR<SP>1</SP>, -NH 2 , -NHR<SP>1</SP>, -NR<SP>1</SP> 2 or -NR<SP>1</SP>R<SP>11</SP> and R<SP>11</SP> is a hydrocarbon radical different from R<SP>1</SP>, are obtained by reacting a compound of the formula with an agent selected from water, aqueous ammonia, an aqueous amine of the formula R<SP>1</SP>NH 2 , R<SP>1</SP>R<SP>11</SP>NH or R<SP>1</SP> 2 NH, or a compound providing RO<SP>-</SP> ions or OH- ions and an alkali metal and where necessary, with a protic solvent providing H<SP>+</SP> cations, for example an alkanol having less than 7 carbon atoms, water or ammonium hydroxide. The reaction may be carried out in one step in a protic solvent or in two steps by carrying out the first stage of the reaction in an aprotic solvent. The starting materials in which X is an ester group may be obtained by reaction of the corresponding cyclic ketone with a dialkyl carbonate; starting materials wherein X is a nitro group may be prepared by nitration of the corresponding ester derivative. The products of the invention may be further worked up, for example, by hydrolysis of ester derivatives to the free acids or by reduction of the nitro derivatives to give the corresponding amino-derivatives; cyclic ethylene brassylate may be obtained by heating brassylic acid with ethylene glycol followed by depolymerization by heating.

Flash glow type 1,2-dioxetane

1,2-DIOXETAN COMPOUNDS, THEIR PREPARATION AND THEIR USE FOR THE DETERMINATION OF THIOLS AND ACETYLCHOLINESTERASE

The invention relates to 1,2-dioxetanes of formula (I) wherein R<1> represents a hydrogen atom or an organic group such as a methoxy or ethoxy; R<2> is an optionally substituted divalent aromatic group, for example a phenylene group; R<3> is an ortho or para-S substituted polyaromatic group or phenyl, for example a dinitrophenyl group; and R<4> and R<5> are alkyl or aryl groups or preferably form together a polycycloalkyl group that is linked to the dioxetane cylce by means of a spiranic union, for example an adamantyl group. The 1-2 dioxetane compounds can be used to dose thiols and acetylcholinesterase.

Compounds, mixtures, liquid crystal compositions, cured products, optically anisotropic bodies, reflective films

Oxidation process

2121339 9308144 PCTABS00021 A process for oxidising a substrate susceptible to nucleophilic oxidation by reacting a bicarbonate or monopersulphate solution with the substrate is disclosed. In one aspect the substrate is introduced into the reaction mixture in an inert carrier gas, which can also serve to sweep the product out of the mixture. In a second aspect, the oxidant solution is obtained by a two stage neutralisation of a Caro's acid solution, the first stage to e.g. 0.5 to 2.0 and the second stage to about 7 to 9. In preferred embodiments, the substrate is introduced into partially neutralised Caro's acid, and the second stage neutralisation in the presence of the substrate is most preferably carried out with an alkali salt such as sodium bicarbonate. The process can employ relatively low ratios of substrate: Caro's acid oxidant and homogeneous reaction conditions. The process is particularly useful for preparing dioxiranes from ketones.