20-06-2013 дата публикации
Номер: US20130153815A1
The present invention relates to a polymer functionalized with a dye, a nanoparticle comprising the dye-functionalized polymer on its surface, as well as to methods of preparing the same. In particular, it relates to a bimodal imaging agent, comprising said nanoparticles functionalized with a polymer bearing a dye with luminescence properties, and fabrication methods of the same. 3. The polymer according to claim 2 , wherein L is a linker group selected from the group consisting of —OR claim 2 , —NRR claim 2 , —SR claim 2 , —O—C(O)—R claim 2 , and —R claim 2 ,wherein:{'sup': 4', '5, 'sub': 2', 'k', '2', 'k', '2', 'k', '2', 'k', '2', 'k, 'Ris selected from the group consisting of —(CH)—, —(CH)—O—, —(CH)—NR—, —(CH)—S—, and —(CH)—C(O)—O—,'}{'sup': '5', 'sub': 1', '6, 'Ris hydrogen or C-Calkyl, and'}k is an integer from 1 to 10.5. The polymer according to claim 1 , wherein Ris —NRR′ claim 1 , —OR claim 1 , or —SR claim 1 , with R being selected from the group consisting of C-Calkyl claim 1 , C-Calkenyl claim 1 , and C-Calkynyl claim 1 , and R′ being hydrogen or C-Calkyl claim 1 , with the alkyl claim 1 , alkenyl and alkynyl groups being optionally substituted.6. The polymer according to claim 5 , wherein Ris an —NH(CH)CH.8. A nanoparticle comprising on its surface a polymer according to claim 1 , wherein the nanoparticle is a magnetic nanocrystal.9. The nanoparticle according to claim 8 , wherein the magnetic nanocrystal comprises a material selected from the group consisting of iron claim 8 , cobalt claim 8 , nickel claim 8 , niobium claim 8 , and magnetic iron oxides and hydroxides such as maghemites claim 8 , magnetites claim 8 , and feroxyhytes.10. The nanoparticle according to claim 9 , wherein the magnetic nanocrystal comprises or consists of magnetite.14. The method according to claim 13 , wherein L is a linker group selected from the group consisting of —OR claim 13 , —NRR claim 13 , —SR claim 13 , —O—C(O)—R claim 13 , and —R claim 13 , wherein:{'sup': 4', '5, ' ...
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