07-01-2021 дата публикации
Номер: US20210002325A1
Принадлежит:
Provided herein are, inter alia, non-toxic, bioreactive unnatural amino acids and methods of using same. 3. The biomolecule conjugate of claim 2 , wherein{'sup': 1', '3A', '3A', '3A', '3A', '3B, 'sub': '2', 'Lis a bond, —S(O)—, —NR—, —O—, —S—, —C(O)—, —C(O)NR—, —NRC(O)—, —NRC(O)NR—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;'}{'sup': 2', '4A', '4A', '4A', '4A', '4B, 'sub': '2', 'Lis a bond, —S(O)—, —NR—, —O—, —S—, —C(O)—, —C(O)NR—, —NRC(O)—, —NRC(O)NR—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; and'}{'sup': 3A', '3B', '4A', '4B, 'R, R, R, and Rare independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.'}4. The biomolecule conjugate of claim 2 , wherein Xis —NH— claim 2 , —O— claim 2 , or imidazolylene.5. The biomolecule conjugate of claim 1 , wherein the first biomolecule moiety is a peptidyl moiety claim 1 , a nucleic acid moiety claim 1 , or a carbohydrate moiety.6. The biomolecule conjugate of claim 5 , wherein the first biomolecule moiety is a peptidyl moiety; and wherein the peptidyl moiety is covalently bonded to the bioconjugate linker via lysine claim 5 , histidine claim 5 , or tyrosine.7. The biomolecule conjugate of claim 1 , wherein the second biomolecule moiety is a peptidyl moiety claim 1 , a nucleic acid moiety claim 1 , or a carbohydrate moiety.8. The biomolecule conjugate ...
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