Processes for preparing modulators of alpha-1 antitrypsin
Номер патента: CA3190103A1
Опубликовано: 03-02-2022
Автор(ы): Adam Looker, Cavan Mckeon Bligh, Cristian Harrison, Robert Daniel Giacometti, Stefanie Roeper, Stephen W. LAWS
Принадлежит: Vertex Pharmaceuticals Inc
Опубликовано: 03-02-2022
Автор(ы): Adam Looker, Cavan Mckeon Bligh, Cristian Harrison, Robert Daniel Giacometti, Stefanie Roeper, Stephen W. LAWS
Принадлежит: Vertex Pharmaceuticals Inc
Реферат: This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran -4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1), 3-[5-(4-fluorophenyl)-6-isopropyl-1H-pyrrolo[2,3-f]indazol-7-yl]propanoic acid (Compound 2), or a pharmaceutically acceptable salt of any of the foregoing.
Processes for preparing modulators of alpha-1 antitrypsin
Номер патента: US20230279010A1. Автор: Adam Looker,Stefanie Roeper,Cristian Harrison,Cavan Mckeon Bligh,Robert Daniel Giacometti,Stephen W. LAWS. Владелец: Vertex Pharmaceuticals Inc. Дата публикации: 2023-09-07.