Process for the preparation of 1,3-diaza-spiro (4.4) non-1-en-4-one derivatives and 1-cyano-1-acylaminocyclopentane intermediates
Номер патента: AU8553798A
Опубликовано: 16-02-1999
Автор(ы): Agnes Kunsztne Karasz, Antal Gajary, Attila Kis-Tamas, Attila Nemeth, Attila Supic, Csaba Huszar, Endre Kollar, Erzsebet Bognar, Ilona Dervalicsne Zrinyi, István Mészáros, Karoly Gyüre, Katalin Dubovszki, Lajosne Pali, Peter Aranyosi, Zoltan Makovi, Zsuzsanna Csetrine Hari, Zsuzsanna Nád
Принадлежит: SANOFI SA
Опубликовано: 16-02-1999
Автор(ы): Agnes Kunsztne Karasz, Antal Gajary, Attila Kis-Tamas, Attila Nemeth, Attila Supic, Csaba Huszar, Endre Kollar, Erzsebet Bognar, Ilona Dervalicsne Zrinyi, István Mészáros, Karoly Gyüre, Katalin Dubovszki, Lajosne Pali, Peter Aranyosi, Zoltan Makovi, Zsuzsanna Csetrine Hari, Zsuzsanna Nád
Принадлежит: SANOFI SA
Реферат: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group, and the resulting compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I) or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or the compounds of formula (I) are liberated from their acid addition salts. Thus a process for the preparation of intermediates useful in synthesis of angiotensin II antagonists is disclosed.
Process for the preparation of 1,3-diaza-spiro (4.4) non-1-en-4-one derivatives and 1-cyano-1-acylaminocyclopentane intermediates
Номер патента: CA2297189C. Автор: Antal Gajary,Attila Supic,Attila Kis-Tamas,Attila Nemeth,Endre Kollar,Csaba Huszar,Lajosne Pali,István Mészáros,Karoly Gyüre,Zoltan Makovi,Zsuzsanna Nád,Peter Aranyosi,Erzsebet Bognar,Zsuzsanna Csetrine Hari,Ilona Dervalicsne Zrinyi,Katalin Dubovszki,Agnes Kunsztne Karasz. Владелец: Sanofi Aventis France. Дата публикации: 2007-08-28.