Process for the preparation of amino-ketones
Реферат: 1309403 Preparation of amino ketones F HOFFMAN-LA ROCHE & CO AG 12 May 1970 [13 May 1969 18 June 1969] 22804/70 Heading C2C Amino-ketones of the general formula wherein R<SP>1</SP> is H or C 1-7 alkyl, R<SP>2</SP> is C 1-7 or aralkyl, or R<SP>1</SP> and R<SP>2</SP> together with the adjacent N atom form a 5 or 6 membered saturated heterocyclic ring including at least one further hetero-atom which is N or O, and R<SP>3</SP> is H or alkyl optionally substituted by oxo, protected oxo, hydroxy or protected hydroxy; and n stands for 1, 2 or 3, are prepared by reacting a compound of formula with a vinyl magnesium halide in an inert organic solvent at below 0‹ C. and treating the resulting compounds of formula with an amine of formula R<SP>1</SP>NHR<SP>2</SP>. The aminoketones of Formula (I) are claimed per se in Specification 1,306,726. Reference has been directed by the Comptroller to Specification 1,187,642.
An improved process for lactonization in the preparation of statins
Номер патента: CA2571379C. Автор: Govind Singh,Rajesh Kumar Thaper,Sanjay Jaiswal,Jag Mohan Khanna,Sushil Kumar Dubey,Paramvir Bhadwal,Dinesh R. Panchasara. Владелец: Jubilant Organosys Ltd. Дата публикации: 2012-08-07.