Process for making 1,3-dioxane derivatives
Номер патента: CA1283926C
Опубликовано: 07-05-1991
Автор(ы): Gregory D. Harris
Принадлежит: Imperial Chemical Industries Ltd
Опубликовано: 07-05-1991
Автор(ы): Gregory D. Harris
Принадлежит: Imperial Chemical Industries Ltd
Реферат: A B S T R A C T PROCESS FOR MAKING 1,3-DIOXANE DERIVATIVES The invention provides a novel process for making novel (4-phenyl-1,3-dioxan-cis-5-yl)alkenoic acids of the formula I in which Ra and Rb are independently hydrogen, alkenyl, alkyl, halogenoalkyl, pentafluorophenyl, aryl or aryl-(1-4C)alkyl; or Ra and Rb together are polymethylene; Rc is hydroxy or (1-6C)alkanesulphonamido, A is vinylene, n is 1, Y is polymethylene, and benzene ring B bears various optional substituents. The process involves the reaction of an aldehyde of formula II with an ylid to give an erythro-diol of formula III which is then cyclised to the required dioxane derivative of formula I. The invention also provides a novel process for making the aldehydes of formula XI from the corresponding lactols of formula IIa, which are themselves obtained with the correct trans-stereochemistry by two selective reductions of a trans-phenylparaconic acid of formula V. The compounds of formula I are useful as therapeutic agents.
Process for the preparation of 1,3-dioxane derivatives
Номер патента: KR920010180B1. Автор: 데비드 할리스 그레고리. Владелец: 알렌 브리안 벡크. Дата публикации: 1992-11-19.