Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof
Номер патента: CA2749012A1
Опубликовано: 15-07-2010
Автор(ы): Axel Becker, Christina Donini, Christoph Saal, Clemens Kuehn, Dieter Dorsch, Frank Stieber, Heinz-Hermann Bokel, Oliver Schadt
Принадлежит: Merck Patent GmBH
Опубликовано: 15-07-2010
Автор(ы): Axel Becker, Christina Donini, Christoph Saal, Clemens Kuehn, Dieter Dorsch, Frank Stieber, Heinz-Hermann Bokel, Oliver Schadt
Принадлежит: Merck Patent GmBH
Реферат: The present invention relates to hydrochloride solvates of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)--pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile and crystalline modifications thereof. The present inven-tion further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or pro-phylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysio-logical conditions such as cancer.
Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof
Номер патента: CA2949515C. Автор: Dieter Dorsch,Frank Stieber,Oliver Schadt,Christoph Saal,Axel Becker,Heinz-Hermann Bokel,Clemens Kuehn,Christina Donini. Владелец: Merck Patent GmBH. Дата публикации: 2018-10-23.