Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors .

Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors

Номер патента: EP0808309A1
Опубликовано: 26-11-1997
Автор(ы): Jaroslav Stanek, Jörg Frei
Принадлежит: Ciba Geigy AG, NOVARTIS AG, Novartis Erfindungen Verwaltungs GmbH

Реферат: Described are compounds of formula (I), wherein R1 is hydrogen or hydroxy; R2, R2' and R2' are each independently of the others hydrogen or a substituent other than hydrogen; either R3 is hydrogen or a substituent other than hydrogen and R4 is hydrogen or lower alkyl, or R3 and R4 together form a divalent radical of the formula -(CH2)n- wherein n is 2 or 3; R5 and R6 are each indenpendently of the other hydrogen, alkyl or aryl; and either R7 and R8 are each hydrogen, or R7 and R8 together form a bond; tautomers thereof, provided that at least one tautomerisable group is present; and salts thereof. The compounds inhibit the enzyme S-adenosylmethionine decarboxylase and are suitable, for example, for the treatment of tumors and protozoal infections.

Рисунок 1. Взаимосвязь патентов (ближайшие 20).

Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors

Номер патента: CA2210533C. Автор: Jörg Frei,Jaroslav Stanek. Владелец: NOVARTIS AG. Дата публикации: 2007-12-04.

Imidazole derivatives, their preparation and their use as S-adenosylmethionine decarboxylase (= SAMDC) inhibitors

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Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors

Номер патента: CA2210533A1. Автор: Jörg Frei,Jaroslav Stanek. Владелец: Individual. Дата публикации: 1996-08-01.

Imidazole derivatives, their preparation and their use as S-adenosylmethionine decarboxylase (= SAMDC) inhibitors

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Imdazol-derivate, deren herstellung und deren verwendung als s-adenosylmethionin decarboxylase (=samdc) inhibitoren

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Thiazolopyrimidines and their use as modulators of chemokine receptor activity

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Novel peroxide derivatives, their process of preparation and their use in human medicine and in cosmetics for the treatment or prevention of acne

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Crystal forms of imidazole derivative

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Azaindole derivatives, process for their preparation, and their use as antitumor agents

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Mb-530b derivatives, their preparation and pharmaceutical compositions containing them

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Novel arylalkylindoles showing affinity to serotonin receptor and useful as drugs, method for their preparing and pharmaceutical compositions containing thereof

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Maleate salts of a quinazoline derivative useful as an antiangiogenic agent

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1h-benzo[d]imidazole derivatives as tlr9 inhibitors for the treatment of fibrosis

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