PEPTIDE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME
Номер патента: ATE146480T1
Опубликовано: 15-01-1997
Автор(ы): Daijiro Hagiwara, Hiroshi Miyake, Masaaki Matsuo
Принадлежит: Fujisawa Pharmaceutical Co
Опубликовано: 15-01-1997
Автор(ы): Daijiro Hagiwara, Hiroshi Miyake, Masaaki Matsuo
Принадлежит: Fujisawa Pharmaceutical Co
Реферат: A compound of the formula : <CHEM> wherein R<1> is lower alkyl, aryl, arylamino, pyridyl, pyrrolyl, pyrazolopyridyl, quinolyl, or a group of the formula : <CHEM> wherein the symbol of a line and dotted line is a single bond or a double bond, X is CH or N, and Z is O, S or NH, each of which may have suitable substituent(s); R<2> is hydrogen or lower alkyl; R<3> is suitable substituent excepting hydroxy; R<4> is lower alkyl which may have suitable substituent(s), and R<5> is ar(lower)alkyl which may have suitable substituent(s) or pyridyl(lower)alkyl, or R<4> and R<5> are linked together to form benzene-condensed lower alkylene; R<7> is hydrogen or suitable substituent; A is an amino acid residue excepting D-Trp, which may have suitable substituent(s); and Y is bond, lower alkylene or lower alkenylene, and a pharmaceutically acceptable salt thereof, processes for their preparations and pharmaceutical compositions comprising them as an active ingredient.
METHOD FOR THE PREPARATION OF ENZYME-INHIBITING AMINOACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Номер патента: PT92558B. Автор: Hansjorg Urbach,Bernward Scholkens,Dieter Ruppert,Wolfgang Ruger. Владелец: Hoechst AG. Дата публикации: 1995-08-09.