Methods and products for facile microbial expression of dna sequences
Номер патента: CA1340371C
Опубликовано: 02-02-1999
Автор(ы): Herbert L. Heyneker, Herman Albert De Boer, Peter H. Seeburg
Принадлежит: Genentech Inc
Опубликовано: 02-02-1999
Автор(ы): Herbert L. Heyneker, Herman Albert De Boer, Peter H. Seeburg
Принадлежит: Genentech Inc
Реферат: Disclosed is a method for constructing a DNA sequence encoding a desired polypeptide in such a manner as to insure that, on transcription in an appropriate host, the corresponding messenger RNA demonstrates levels of conformational structure insufficient to interfere with its accessibility for efficient ribosomal translation. The production of bovine growth hormone is illustrative of the invention.
A plasmid vector useful for the expression of a foreign dna sequence
Номер патента: WO1995010620A1. Автор: Christopher A. Zook,Richard M. Synenki,James R. Mcmullen. Владелец: Mallinckrodt Veterinary, Inc.. Дата публикации: 1995-04-20.