STEROIDESTERS OF N- (2-HALOGENETHYL) -N-NITROSO-CARBAMOYL AMINO ACIDS AND THEIR PEPTIDES, AND PROCEDURES FOR THEIR PREPARATION
Номер патента: DK533583D0
Опубликовано: 22-11-1983
Автор(ы): Gerhard Eisenbrand, Joachim Schreiber
Принадлежит: Deutsches Krebsforsch
Опубликовано: 22-11-1983
Автор(ы): Gerhard Eisenbrand, Joachim Schreiber
Принадлежит: Deutsches Krebsforsch
Реферат: PCT No. PCT/EP83/00090 Sec. 371 Date Nov. 17, 1983 Sec. 102(e) Date Nov. 17, 1983 PCT Filed Mar. 23, 1983 PCT Pub. No. WO83/03414 PCT Pub. Date Oct. 13, 1983.Steroid-N-(2-halogen ethyl)-N-nitroso-carbamoyl-amino acid or peptide esters of the general formula: <IMAGE> +TR <IMAGE> where R1 and R2, which may be identical or different, mean the radical of an amino acid beyond the C atom in the beta position (if present), R3 means the radical of a steroid or a stilbene derivative pharmacologically similar in action, n is a number from 0-5 and Hal stands for chlorine or fluorine, as well as the method for preparing them by the conversion of an appropriate carbamoyl-amino acid or carbamoyl-peptide in a manner known per se with steroid alcohols or the conversion of steroid-amino acid or steroid-peptide esters with corresponding N-nitroso-carbamoylation or corresponding N-nitroso-carbamoyl-amino acids or peptides in a manner known per se.
Steroid esters of N-(2-halogenoethyl)-N-nitroso-carbamoyl-amino acids and peptides thereof, as well as methods for preparing them
Номер патента: US4609496A. Автор: Gerhard Eisenbrand,Joachim Schreiber. Владелец: Deutsches Krebsforschungszentrum DKFZ. Дата публикации: 1986-09-02.