Method for the production of 2-keto-l-gulonic acid-c4-c10 alkyl esters
Номер патента: AU2003293666A1
Опубликовано: 03-06-2004
Автор(ы): Georg Grossmann, Martin Merger, Thomas Domschke, Tillmann Faust
Принадлежит: BASF SE
Опубликовано: 03-06-2004
Автор(ы): Georg Grossmann, Martin Merger, Thomas Domschke, Tillmann Faust
Принадлежит: BASF SE
Реферат: The invention relates to a method for producing 2-keto-L-gulonic acid-C<SUB>4</SUB>-C<SUB>10 </SUB>alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C<SUB>4</SUB>-C<SUB>10 </SUB>alcohol. The inventive method is characterized by the fact that an aqueous KGS solution is reacted with a C<SUB>4</SUB>-C<SUB>10 </SUB>alcohol up to an esterification degree of 20 to 70 percent in a pre-esterification process carried out under acidic catalysis conditions; and the obtained product is dehydrogenated with an unsaturated, branched or unbranched C<SUB>4</SUB>-C<SUB>10 </SUB>alcohol in a continuous rectification device, whereby the esterification reaction continues, n-butanol preferably being used as the alkyl alcohol. In a preferred embodiment, the aqueous KGS solution is concentrated up to or beyond the limit of solubility prior to the esterification process, preferably by catalyzing a homogeneous or heterogeneous catalyst, especially sulfonic acid, at temperatures of 50 to 120° C. In another embodiment, the produced KGS ester is reacted in one or several additional steps so as to obtain L-ascorbic acid.
Method for the production of 2-keto-l-gulonic acid-c4-c10 alkyl esters
Номер патента: WO2004043880A3. Автор: Tillmann Faust,Martin Merger,Thomas Domschke,Georg Grossmann. Владелец: Georg Grossmann. Дата публикации: 2004-07-29.