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  • 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same

1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same

Номер патента: AU2021226297B2
Опубликовано: 21-12-2023
Автор(ы): Chang Kon Lee, Hyunjin Michael KIM, Moo Sung Ko, Seo Young Lee, Seok Hyoun YUN
Принадлежит: Chong Kun Dang Corp
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Benzamide derivatives useful as histone deacetylase inhibitors

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Antitumour pharmaceutical compositions and process for preparing the same.

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A combination comprising a signal transduction inhibitor and an epothilone derivative, a pharmaceutical composition containing said combination, and its use in the treatment of a proliferative disease.

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Water-dispersible, biodegradable compositions and containers and the like made therefrom

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Package and method for producing the same

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INSTALLATION FOR VIBRATION TREATMENT OF DETAILS IN A CONTAINER 1 The invention can be used in the area of vibration processing of parts. Vibration installations for processing parts in a container driven in 5 oscillatory motion from a vibration exciter located at an angle to the vertical are known. in the frame with the possibility of reciprocating movement across the axis of the vibrator relative to the frame on which the vibrator is fixed. This eliminates the Secondary circulation when using containers with straight walls due to a change in the relative position of the vibrator and the working container. In FIG. 1 shows the described installation; in fig. 2 is a cross section along A — A in FIG. one; in fig. 3 is a longitudinal section along B — B in FIG. 2. The vibration unit contains a working chamber 1, 25 vibrator 2 with a drive 3, a separator 4 and equipment 5 for flushing placed in a common casing. The working chamber guides 6 is installed and fixed in the guides 7 of the frame 8 and can be reciprocated gel movement across the axis of the vibrator. The frame is located on the springs 9 supported on the casing frame. The vibrator is placed on the frame at an angle a to the vertical axis of symmetry O — O of the working chamber. Depending on the operations performed and the configuration of the parts being machined, the working chamber 1 can be installed and fixed in any intermediate position between the front one shown in FIG. 2 the main line, and the extreme rear, shown by the dashed line. At the same time, in order to exclude the secondary circulation zone, the angle a must be changed within 15-30 °. In the side wall of the working chamber an outlet is made at an angle to its vertical axis of symmetry for unloading the working mass and parts into the separator. The outlet is closed by a plug 10. The separator is mounted on the springs 11 under the working chamber. The separator 4 during operation receives oscillations from the vibrator through a folding U-shaped lever 12 pivotally mounted on the separator, which is rigidly connected with a quick disconnect connection of fingers 13, pursed with springs 14 with a bracket 15 mounted on the vibrator. With fingers, handles 16 are connected, with the help of which fingers are pulled out of the connection with the bracket in case it is necessary to disconnect the separator from the vibrator.

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A novel pharmaceutical composition for treatment of autoimmune diseases and preparation method thereof

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Pharmaceutical composition possessing anti-inflammatory, immunotropic, antiallergic and wound healing action

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Polyactive terpenoid substance abisil-2, pharmaceutical composition on its basis and ways of its application

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Pharmaceutical composition increasing cyclic amp content and availability in vivo, and preparation method thereof

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Tricyclic benzodiazepines, pharmaceutical composition containing the same and methods for hypertension treatment

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Pharmaceutical composition for blood sugar and fat control, its manufacturing and administration thereof

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Poorly soluble complex or solvate thereof, pharmaceutical composition, and application thereof.

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