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Virus encoding an anti-tcr-complex antibody or fragment

Номер патента: EP3389683A1
Опубликовано: 24-10-2018
Автор(ы): Alice Claire Noel BROMLEY, Brian Robert Champion
Принадлежит: Psioxus Therapeutics Ltd

Реферат: The present disclosure relates to a replication deficient oncolytic viral vector or replication capable oncolytic virus encoding an antibody or a binding fragment thereof to the antigen-specific T-cell receptor complex (TCR) for expression on the surface of a cancer cell, pharmaceutical compositions comprising the same, and use of any one of the same in treatment, particularly in the treatment of cancer.

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Group b adenovirus encoding an anti-tcr-complex antibody or fragment

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Virus encoding an anti-tcr-complex antibody or fragment

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Group b adenovirus encoding an anti-tcr-complex antibody or fragment

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humanized antibody or fragment thereof that binds to human cd19, isolated nucleic acid, vector, host cell, method for producing a humanized antibody or fragment thereof that binds to human cd12, composition, immunoconjugate, use of humanized antibody or fragment of the same, article of manufacture and kit

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CDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, and process for the production of such viruses encoding additional antigenically active proteins

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cDNA CORRESPONDING TO THE ANTIGENOME OF NONSEGMENTED NEGATIVE STRAND RNA VIRUSES, AND PROCESS FOR THE PRODUCTION OF SUCH VIRUSES ENCODING ADDITIONAL ANTIGENICALLY ACTIVE PROTEINS

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ISOLATED HUMAN MONOCLONAL ANTIBODY OR ANTIGEN CONNECTION PORTION OF THE SAME, ISOLATED POLYPEPTIDE, COMPOSITION, ISOLATED NUCLEIC ACID, EXPRESSION VECTOR, HOST VECTOR, Hepatitis C, HCV VT, HCV VT HEPATITIS C (HCV) AND TO IDENTIFY ANTIBODY OR FRAGMENT OF THE SAME, ANTIBODY OR FRAGMENT OF THE SAME, AND HEPATITE C (HCV) RECOMBINANT E2 PROTEIN

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Recombinant myxomatosis virus encoding non-myxomatosis antigen - for dual vaccination of rabbits and hares e.g. against myxomatosis and rabbit viral haemorrhagic disease

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Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof

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Vaccine against human immunodeficiency virus-1 and acquired immunodeficiency syndrome, comprising defective Tat protein or fragment which can attach to TAR but not cause transactivation

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Pharmaceutical composition and biomaterial comprising fusion peptide in which bone tissue-selective peptide bound to parathyroid hormone (PTH) or fragment thereof

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Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof, and therapeutic uses thereof

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Recombinant protein, carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof, therapeutic uses thereof

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Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof

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Recombinant protein, carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof, therapeutic uses thereof

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DNA ENCODING IgE RECEPTOR ALPHA-SUBUNIT OR FRAGMENT THEREOF

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cDNA encoding IgE receptor subunit or fragment thereof, method for producing soluble subunit polypeptide using it, and vector comprising said cDNA

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DNA encoding IgE receptor alpha subunit or fragment thereof

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DNA encoding IgE Receptor α-subunit or fragment thereof

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Endogenous retrovirus-k (ERVK) encodes an alternate envelope protein

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ACTIVATION OF TUMOR-REACTIVE LYMPHOCYTES ANTIBODIES OR GENES RECOGNIZING CD3 OR 4-1BB

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isolated monoclonal antibody or antigen-binding portion thereof, antibody fragment, mimetic antibody, immunoconjugate, isolated nucleic acid molecule composition, expression vector, host cell, method for preparing an anti-bmp2 or anti-bmp4 antibody, Method for treating or preventing a disease associated with normal bone formation and ossification, hybridoma and method for preparing the antibody

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A simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome or polyplex for systemic administration of a therapeutic or diagnostic agent

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Methods and composition comprising denosumab or an antibody or antigen binding domain, fragment or derivative thereof, immunoreactive with a rankl/opgbp peptide for use in the treatment, prevention or alleviation of male infertility

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Combination of an agonistic anti-cd40 monoclonal antibody or a cd40 ligand and inactivated or attenuated bacteria for use in the treatment and/or prevention of mastitis

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Isolated human antibody or antigen binding portion thereof which binds human TNF , recombinant human antibody or antigen binding portion thereof, isolated nucleic acid encoding a light or heavy chain of the antibody, optionally a region thereof, recombinant

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isolated mammalian antibody or antigen-binding fragment thereof, caninized antibody or caninized antigen binding fragment thereof, caninized monoclonal antibody or antigen-binding fragment thereof, isolated nucleic acid, expression vector, host cell, peptide isolated, fusion protein, pharmaceutical composition, and method for decreasing the activity of an immune cell?

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Use of activated t-cells to enhance anti-tumor activity of bispecific antibodies or bites

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DNA encoding an anti-CD40 IgG2 antibody having amino acid mutations

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PREPARATION OF ANTIBODY OR AN ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOMES FOR SYSTEMIC ADMINISTRATION OF THERAPEUTIC OR DIAGNOSTIC AGENTS AND USES THEREOF

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Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB

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METHOD FOR IMPROVING FUNCTIONAL PROPERTIES OF AN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT

Номер патента: RU2014142680A. Автор: Леонардо БОРРАС,Дэвид УРЕХ. Владелец: Эсбатек, Эн Элкон Биомедикал Рисёрч Юнит Ллк. Дата публикации: 2016-05-20.

HUMAN OR HUMANIZED ANTIBODY OR FUNCTIONAL FRAGMENT OF THE SAME SPECIFIC FOR LYMPHOPOYETINE ESTROMAL TIMICA, TSLP; POLINUCLEOTIDE THAT CODIFIES IT; CELL GUESTS THAT UNDERSTANDS IT; PHARMACEUTICAL COMPOSITION THAT INCLUDES THE ANTIBODY; AND METHOD FOR T

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isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody

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monoclonal antibody or antibody fragment, Methods for reducing, blocking, inhibiting, or neutralizing inflammation, pruritis, and scratching in a mammal, and, isolated antibody

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human monoclonal antibody or antigen-binding portion thereof that specifically binds to and activates human cd40, isolated hybridoma cell line, pharmaceutical composition comprising the same, use thereof in the manufacture of a drug and method of manufacturing said antibodies or antigen-binding portion of it

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Anti-sars-cov-2 s protein antibody or antigen-binding fragment thereof, and pharmaceutical composition for preventing or treating sars-cov-2 infection comprising same

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Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb

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Humanized monoclonal antibody or binding fragment that binds and neutralizes the human vascular endothelial growth factor (hvegf); composition that includes it; nucleic acid coding; vector; host cell; its use to treat or prevent a disease mediated by vegf; and hybridoma.

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anti-human tslp receptor antibody or an antigen-binding fragment thereof, polynucleotide, expression vector, method for producing said antibody, pharmaceutical composition and use of said antibody for prevention or treatment of asthma

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Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use

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Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb

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isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody

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ANTI-CD44 HUMAN ANTIBODIES OR FRAGMENTS OF THE SAME; NUCLEIC ACIDS THAT CODE THEM; VECTOR AND CELL GUEST THAT UNDERSTANDS THEM; PHARMACEUTICAL COMPOSITION THAT INCLUDES ANTIBODIES; AND ITS USE TO TREAT THE SYMPTOMS OF DISORDERS MEDIATED

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Retinoblastoma gene product antibodies or immunogenic fragments having specific binding affinity to the rbi protein and methods of detecting tumor cells

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Method of inhibition of retroviral infection (variants), protease inhibitor, nucleic acid encoding an inhibitor and a method of recombinant serine protease inhibitor producing

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ANTIBODY OR AN ANTIGEN-BINDING FRAGMENT OF ANTIBODY, ANTIGEN-BINDING FRAGMENT OF ANTIBODY, PHARMACEUTICAL COMPOSITION, USE OF AN ANTIBODY OR AN ANTIGEN-BINDING FRAGMENT, USE OF A COMPOSITION, VECTOR, TRANSFORMED HOST CELL, AND METHOD FOR PRODUCING AN ANTIBODY

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Oncolytic herpes simplex virus encoding a heterologous nitroreductase

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Oncolytic herpes simplex virus encoding a heterologous nitroreductase

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Antibody or fragment thereof that binds to fcrl1

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Recombinant Lister strain vaccinia virus encoding an anti-VEGF single chain antibody

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method for detecting the presence of a bard1 isoform, isolated and / or purified polypeptide, peptide, kit for detecting the presence of bard1 isoforms, method for discriminating cancer, antibody or fragment thereof, recombinant sirna molecule, modulator of biological activity bard1 isoforms

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Antibodies to MRT-1 protein or fragments thereof

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Immune checkpoint inhibitor, therapeutic agent for immune checkpoint-related disease, immunosuppressant, anti-fibronectin antibody or derivative thereof, fibronectin analog, kit for detecting fibronectin or partial protein thereof, and method for detecting fibronectin or partial protein thereof

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Immune checkpoint inhibitor, therapeutic agent for immune checkpoint-related disease, immunosuppressant, anti-fibronectin antibody or derivative thereof, fibronectin analog, kit for detecting fibronectin or partial protein thereof, and method for detecting fibronectin or partial protein thereof

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PROTEIN AND ITS FRAGMENTS REPRESENTING THE SPECIFIC EXPRESSION OF THE PS2 GENE OF BREAST CANCERS, ANTIBODIES OBTAINED FROM SAID PROTEIN AND / OR FRAGMENTS THEREOF, THEIR APPLICATIONS FOR THE DETECTION AND DIAGNOSIS OF BREAST CANCERS

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RECOMBINANT PROTEIN CARRYING HUMAN PAPILLOMAVIRUS EPITOPES INSERTED IN AN ADENYLATE CYCLASE PROTEIN OR FRAGMENT THEREOF THERAPEUTIC USES THEREOF

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Putative protective antigens or fragments thereof against circumcinced trichostrongylus colubriformis and fasciola hepatica process to prepare an antigen associated with a disease pathogen selected from species fasciola ostertagia and trichostrongylus process to prepare a monoclonal antibody monoclonal antibody process to prepare antigenic diagnostic polypeptide kit to prevent disease in animals process for treating disease in animals

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Induction of immune response against tetanus toxin through administration of mycobacteria expressing tetanus toxin or fragments.

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Monoclonal antibody having immunosuppressive activity or fragment to which antigen thereof is bonded

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Monoclonal antibody having immunosuppressive activity or fragment to which antigen thereof is bonded

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Melanotropin or fragments thereof for treating nerve and skin disease

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ANTI-ADRENOMEDULLIN (ADM) ANTIBODY OR ANTI-ADM ANTIBODY FRAGMENT OR ANTI-ADM NON-IG SCAFFOLD FOR PREVENTION OR REDUCTION OF ORGAN DYSFUNCTION OR ORGAN FAILURE IN A PATIENT HAVING A CHRONIC OR ACUTE DISEASE OR ACUTE CONDITION

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isolated antibody or antigen binding fragment thereof, isolated nucleic acid molecule, vector, methods for producing an isolated antibody or antigen binding fragment thereof, to prepare a conjugate and to alleviate a cancer symptom, conjugate, and , use of a conjugate.

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Polynucleotide encoding an IL-28B polypeptide

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ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, ISOLATED POLYPEPTIDE, ISOLATED NUCLEIC ACID, EXPRESSION VECTOR, HOST CELL, COMPOSITION, METHODS FOR PRODUCING AN ANTIBODY OR ANTIGEN-BINDING FRAGMENT, FOR TREATMENT OF CANCER AND AN INFECTION OR INFECTIOUS DISEASE , FOR DETECTING THE PRESENCE OF A TIGIT PEPTIDE OR A FRAGMENT THEREOF AND FOR ENHANCEMENT OF AN IMMUNE CELL ACTIVITY AND ANTI-TUMOR ACTIVITY OF AN ANTI-TIGITAL ANTIBODY, VACCINE, AND, USE OF AN ANTIGEN-BINDING ANTIBODY OR FRAGMENT

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Monoclonal antibody that specifically binds human tyrp1; fragment of any of the antibodies indicated above; nucleic acid encoding antibody or fragment; expression vector; recombinant cell; use of the antibody or fragment to treat cancer.

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Anti-her2 antibody, a nucleic acid molecule encoding the variable region of said antibody, a method of detecting her2 in a biological sample, an immuno-enzymatic elisa assay and use of said anti-her2 antibody or fragments therefof

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antibody or fragment thereof, binding agent, transgenic animal, hybridoma, vector, pharmaceutical composition, fgf19 and / or fgf21-like signaling induction method, method for activating a klotho beta / fgf receptor complex, method for improving metabolism of glucose in an individual, method of detecting klotho beta, use of antibody or fragment thereof, use of pharmaceutical composition, treatment method and method for improving metabolic parameters

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method for treating a tumor, method for improving tolerability to at least one chemotherapeutic agent, method for increasing survival of an individual having a tumor, method for reducing or preventing tumor recurrence, use of a humanized monoclonal antibody or fragment and antibody thereof humanized monoclonal or fragment thereof

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Viral vector-derived target protein for anticancer therapy and binding molecule or fragment thereof specifically binding thereto

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Viral vector-derived target protein for anticancer therapy and binding molecule or fragment thereof specifically binding thereto

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Viral vector-derived target protein for anticancer therapy and binding molecule or fragment thereof specifically binding thereto

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Viral vector-derived target protein for anticancer therapy and binding molecule or fragment thereof specifically binding thereto

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antibody or fragment thereof, which has immunological reactivity with a caprin-1 protein, pharmaceutical composition and pharmaceutical combination for cancer treatment and / or prevention, and method for treating and / or preventing cancer

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Antibody or fragment thereof binding specifically to mertk, and anti-tumor agent

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Humanized antibody or fragments thereof, which bind to the epidermal growth factor receptor (egfr) in an aberrant expression or truncated egfr? 2-7; host cell; pharmaceutical composition comprising it; and its use to treat cancer.

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Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments

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bispecific monovalent diabodies, bispecific monovalent diabodies, pharmaceutical composition, use of the pharmaceutical composition, cell expressing a polypeptide chain of any of the bispecific monovalent diabodies, polynucleotide encoding the polypeptide, and cell expressing an antibody or a portion of polypeptide or fragment of the same

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ANTIBODIES OR FRAGMENTS THEREOF DIRECTED AGAINST A STAPHYLOCOCCUS AUREUS EPITOPE OF ISAA OR ISAB

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Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity

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Isolated monoclonal antibody or fragment thereof binding prostate specific membrane antigen, conjugates and uses thereof

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Methods for improvement of beta cell function with anti-IL-1β antibodies or fragments thereof

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Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome

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Antibody or fragment that specifically binds to a peptide derived from vimentin

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B-cell depleting agents, like anti-cd20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome

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Anti-CEP antibody or fragment thereof

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ANTIBODIES OR FRAGMENTS THEREOF THAT BIND THYMIC STROMAL LYMPHOPOYETIN (TSLP) AND PHARMACEUTICAL COMPOSITIONS THEREOF

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B-cell depleting agents, like anti-cd20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome

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B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome

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Antibody or fragment thereof and compositions comprising them for treating disease associated with cd154

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B-cell depleting agents, like anti-cd20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome

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Antibody or fragment thereof which binds with human ron protein and use thereof

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Antibodies or fragments thereof against hemopexin for use in the treatment of ocular diseases

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Composition comprising a LINGO antibody or fragment

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Crystals of whole antibodies or fragments thereof, and methods for making and using the crystals

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Anti-pd-1 antibodies, or fragments thereof, for treating hepatitis b

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Monoclonal antibodies, or fragments thereof, that bind hiv gp120 and polynucleotides encoding them

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Crystallization of antibodies or fragments thereof

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Antibody or fragment thereof that binds to interleukin 4 receptor comprising a light and heavy chain variable region; nucleic acid sequences encoding said regions; vector comprising said sequence; host cell; method for producing said antibody; and use of said antibody for immunological disorders.

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Crystallization of antibodies or fragments thereof

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ANTIBODY OR FRAGMENT OF THE SAME THAT SPECIFICALLY LINKS THE VARIOUS OF HUMAN CSF -1R, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, ITS USE FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER AND METHOD TO DETERMINE IF A BASED SUBJECT MATTER AND

Номер патента: AR080698A1. Автор: . Владелец: ImClone LLC. Дата публикации: 2012-05-02.

B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome

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ISOLATED ANTIBODY OR FRAGMENT THEREOF, PHARMACEUTICAL COMPOSITION AND BISPECIFIC MOLECULE

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B cell depleting antibodies, or fragments thereof, compositions comprising the same and use thereof for treating chronic fatigue syndrome

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Antibody or fragment thereof having neutralizing activity against HIV

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Antibodies or fragments thereof binding to RSV F and use thereof

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Composition intended for the immunotherapy of a cancer secreting hCG or fragments of hCG.

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Composition intended for the immunotherapy of a cancer secreting hCG or fragments of hCG.

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Compositions comprising antibodies to lingo or fragments thereof

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Treatment with proadrenomedullin or fragments thereof and binding agents to adrenomedullin in patients infected with coronavirus

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Vaccine compositions comprising c-c motif chemokine 22 (ccl22) or fragments thereof

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Adjuvant composition comprising fha protein or fragment of fha protein in free form

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ANTIBODY, NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, CELL, COMPOSITION, MIXTURE, USE OF A CHEMICAL ANTIBODY OR A FRAGMENT OF THE SAME OR A FRAGMENT OF THE SAME AND / OR A PART OR A FUNCTION OR A PART OR A FUNCTION MIXTURE, METHODS FOR PREPARING A PHARMACEUTICAL COMPOSITION OR MIXTURE, TO PREVENT, TREAT OR RELIEVE THE EFFECTS OF A DISEASE, DIAGNOSTIC DISEASE, OR CONDITION ASSOCIATED WITH A DETERMINATION OF THE DETERMINATION OF CAROGUE DETERMINATION IN A FABRIC AND / OR BODY FLUIDS, TEST KITS FOR DISEASE AND DIAGNOSTIC TESTING AND CONDITIONS ASSOCIATED WITH AMYLOID, LIGHT CHAIN VARIABLE REGION, HEAVY CIRCLE, GENELE DESENGER, GENELE DIAGET LINES PRE-FORMED BETA-AMYLOID FIBERS TO PREVENT ABETA-INDUCED NEURON DEGRADATION, TO DIAGNOSE A PREDISPOSITION TO A DISEASE OR CO NDITION ASSOCIATED WITH AMYLOID IN A PATIENT, TO MONITOR MINIMUM RESIDUAL DISEASE IN A PATIENT, TO PROGNOSE LIABILITY OF A PATIENT WHO IS TREATED WITH AN ANTIBODY OR A COMPOSITION OF VACCINE, TO REDUCE THE CARBON LOAD TO THE CIRCLE THE NUMBER OF PLATES IN AN ANIMAL BRAIN, TO REDUCE THE TOTAL SOLUBLE OPEN QUANTITY IN AN ANIMAL BRAIN AND TO HOLD OR INCREASE COGNITIVE MEMORY CAPACITY IN A MAMMALIAN.

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ANTI-ADRENOMEDULLIN (ADM) ANTIBODY OR ANTI-ADM ANTIBODY FRAGMENT OR ANTI-ADM NON-IG SCAFFOLD FOR PREVENTION OR REDUCTION OF ORGAN DYSFUNCTION OR ORGAN FAILURE IN A PATIENT HAVING A CHRONIC OR ACUTE DISEASE OR ACUTE CONDITION

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METHODS FOR TREATING CANCER, FOR MANUFACTURING AN ANTI-ICOS ANTIBODY OR ANTIGEN BINDING PORTION OF THE SAME, FOR MANUFACTURING AN ANTIGEN ANTIBODY OF THE SAME, FOR MANUFACTURING AN ANTIGENO ANTIGENO ANTIGENO ANTIGENE OF THE SAME, ANTI-ICOS ANTIBODY OR ANTIGEN-BINDING FRAGMENT OF THE SAME AND AN ANTI-PD1 ANTIBODY OR ANTIGEN-BINDING FRAGMENT OF THE SAME, ANTI-ICOS ANTIBODY OR ANTI-ANTIGEN BINDING FRAGMENT OF THE SAME AND THE AGE OF OR ANTIGEN BINDING FRAGMENT OF THE SAME, USE OF AN ANTI-ICOS ANTIBODY OR ANTIGEN BINDING PORTION OF THE SAME AND ANTI-PD1 ANTIBODY OR ANTIGEN BINDING PORTION, POLYNUCLEOTIDE, VECTOR, AND, CÉPÉ

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Treatment of pruritis employing anti-il13ra1 antibody or binding fragment thereof

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Human anti-cd22 monoclonal antibody or an antigen-binding fragment thereof; nucleic acid, vector, host cell; Preparation method; composition; immunoconjugate; and its use to inhibit the growth of a tumor or treat an inflammatory or autoimmune disorder in a subject.

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isolated anti-fc15 antibody or antigen-binding fragment thereof, isolated anti-fc155 scfv antibody, isolated antibody or antigen-binding portion thereof, composition, immunoconjugate, bispecific molecule, isolated nucleic acid, expression vector, host cell , method for detecting fcrl5 in an entire cell or tissue, method for treating cancer in an individual, use of antibody or antigen-binding fragment thereof, cancer treatment kit

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig protein scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease

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isolated il-6 antibody, engineered isolated human antibody, isolated human or engineered human antibody, molecule and isolated nucleic acid vector, method for the production of an il-6 antibody, composition comprising the isolated il-6 antibody, antibody or anti-biotype fragment , use of said antibody, medical device comprising an il-6 antibody and article made for pharmaceutical or human diagnostic use

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isolated monoclonal antibody or antigen-binding fragment thereof, isolated nucleic acid molecule, pharmaceutical composition, and method for lowering blood glucose levels or for treating a condition or disease.

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Anti- CGRP or anti-CGRP R antibody or antibody fragment are used to treat or prevent the chronic and diarrhoea of acute form purposes

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Anti- CGRP or anti-CGRP-R antibody or antibody fragment are used to treat or prevent the purposes of chronic and acute form diarrhea

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock

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Monoclonal antibody or antigen binding fragment thereof that binds to integrin alpha-v-beta-6; composition; use to treat or prevent fibrosis, psoriasis, cancer, acute lung damage or alpont syndrome; hybridoma (atcc pta-3645); in vitro method to inhibit the growth of a cancer cell (divisional of application No. 513-03).

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease

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isolated antibody or antigen binding fragment thereof, isolated nucleic acid molecule, expression vector, methods for producing antibody or antigen binding fragment thereof, and for treating a condition or disease, pharmaceutical composition, and use of an isolated antibody or antigen-binding fragment thereof.

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il-1 beta binding antibody or il-1 beta binding fragment thereof, Nucleic acid, vector, cell, transgenic animal, hybridoma, composition, and, methods of treating or preventing a disease or disease related to 1 in a mammal, and preparing an affinity matured il-1 beta-binding polypeptide

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Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition

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monoclonal antibody or antigen-binding fragment thereof, pharmaceutical composition, monoclonal antibody or antigen-binding fragment thereof for use, method of treating ischemia-reperfusion injury, method of treating cancer in a human patient, method of evaluating expression CD47 into tumor and / or immune cells using a monoclonal antibody or antigen-binding fragment thereof

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Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease

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Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea

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ISOLATED HUMAN ANTI-TAU MONOCLONAL ANTIBODIES OR A TAU-BINDING FRAGMENT THEREOF, METHODS OF PREPARATION THEREOF, POLYNUCLEOTIDE OR POLYNUCLEOTIDES, VECTOR OR VECTORS, COMPOSITION, IN VITRO METHOD OF DIAGNOSIS OR MONITORING THE PROGRESSION OF A NEURODEHUMANINATIVE TAUOPATHY , IN VITRO METHOD TO DIAGNOSE A NEURODEGENERATIVE TAUOPATHY IN A HUMAN INDIVIDUAL, AND USEFUL KIT FOR THE DIAGNOSIS OF A NEURODEGENERATIVE TAUOPATHY

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy

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Methods for reducing an adverse immune response to a foreign antigen in a human subject with anti-cd4 antibodies or cd4-binding fragments thereof or cd4-binding molecules

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Method of modulating the activity of adrenomedullin in a subject in need of therapeutic intervention for organ dysfunction or organ failure associated with adrenomedullin (adm) activity by administering an anti-adrenomedullin (adm) antibody or an anti-adm fragment to the subject

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isolated human monoclonal antibody or antigen-binding portion thereof, composition, immunoconjugate, isolated nucleic acid molecule, expression vector, host cell, method for preparing an anti-fucosyl-gm1 antibody and method for treating or preventing a disease defined by the growth of tumor cells expressing fucosil-gm1

Номер патента: BRPI0620553A2. Автор: Alison Witte,Peter Brams,Josephine M Cardarelli,Cynthia A Vistica,Eric H Holmes. Владелец: Medarex Inc. Дата публикации: 2011-11-16.

Isolated monoclonal antibody or an antigen-binding portion thereof, or an antibody fragment, composition comprising them, nucleic acid molecule, hybridoma and methods for preparing an anti-cadm1 antibody

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Methods for reducing an adverse immune response to a foreign antigen in a human subject with anti-cd4 antibodies or cd4-binding fragments thereof or cd4-binding molecules

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ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, COMPOSITION, AND, USE OF ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF

Номер патента: BR112012010707B1. Автор: Leonard G. Presta. Владелец: Merck Sharp & Dohme Corp. Дата публикации: 2022-08-30.

Method of modulating the activity of adrenomedullin in a subject in need of therapeutic intervention for organ dysfunction or organ failure associated with adranomedullin (ADM) activity by administering an anti-adrenomedullin (ADM) antibody or an anti-ADM antibody fragment to the subject

Номер патента: US10221238B2. Автор: Andreas Bergmann. Владелец: ADRENOMED AG. Дата публикации: 2019-03-05.

Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof

Номер патента: WO2018109228A1. Автор: Adriaan VOORS. Владелец: ADRENOMED AG. Дата публикации: 2018-06-21.

Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof

Номер патента: EP3339324A1. Автор: Adriaan VOORS. Владелец: SPHINGOTEC GMBH. Дата публикации: 2018-06-27.

anti-sirpalpha antibody or antigen-binding fragment thereof, pharmaceutical composition, and combination of anti-sirpalpha antibody or pharmaceutical composition.

Номер патента: BR112019023754A2. Автор: ROUWENDAL Gerard,FRANKE Katarina,Franciscus Maria Verheijden Gijsbertus,Lottie Matlung Hanke,Jan Arends Roland,Kars Van Den Berg Timo. Владелец: Synthon Biopharmaceuticals BV. Дата публикации: 2020-06-09.

Combination of anti-HLA-DR antibodies or anti-TROP-2 antibodies with microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors leads to a significant improvement of cancer treatment outcome

Номер патента: CN107735104B. Автор: D.M.戈登伯格,T.M.卡迪洛. Владелец: Immunomedics Inc. Дата публикации: 2022-05-03.

New isolated antibody or its functional fragments that binds to human insulin-like growth factor I receptor and inhibits tyrosine kinase activity, for treating cancer, psoriasis or atherosclerosis

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A method for predicting the efficacy of an anti-PD-1 antibody or anti-PD-L1 antibody therapy, a method for evaluating the malignancy of cancer, and a method for increasing the efficacy of an anti-PD-1 antibody or anti-PD-L1 antibody therapy

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antibody or functional antibody fragment, pharmaceutical composition, use of an antibody or functional fragment thereof, polynucleotide, vector, and transformed host cell.

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Anti-Adrenomedullin (ADM) antibody or anti-ADM antibody fragment or an anti-ADM non-Ig protein scaffold for use in therapy

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isolated antibody or antigen binding fragment thereof, pharmaceutical composition, and method for treating a disease or disorder.

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Compositions and methods of use comprising combinations of anti-cd74 antibodies with a therapeutic agent. the therapeutic agent may be attached to the anti-cd74 antibody or may be separately administered, either before, simultaneously with or after the anti-cd74 antibody

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isolated antibody or antigen binding fragment thereof, drug-to-antibody conjugate, methods for eliminating cells expressing low levels of prlr and a class i cytokine receptor and for inhibiting or attenuating tumor growth, and, pharmaceutical composition

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Methods of suppressing or treating an inflammatory bowel disease by administering an antibody or portion thereof that binds to AILIM

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ISOLATED RECOMBINANT ANTIBODY OR ANTIGEN-BINDING FRAGMENT OF IT, PHARMACEUTICAL COMPOSITION, POLYNUCLEOTIDE MOLECULE, VECTOR, CELL, AND METHOD TO PREVENT, TREAT OR IMPROVE AT LEAST ONE SYMPTOM OF INFLUENZA INFECTION

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig protein scaffold for use in therapy

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Monoclonal antibody or an antigen-binding fragment thereof, uses thereof, hybridoma cell line for production thereof, pharmaceutical composition comprising a monoclonal antibody or an antigen-binding fragment thereof, in vitro method for the diagnosis of an amyloid-associated disease and kit therefor

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy

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method for treating cancer, and, anti-icos antibodies or antigen binding portion thereof and an anti-ox40 antibody or antigen binding portion thereof

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MONOCLONAL ANTIBODY, POLYNUCLEOTIDE, COMPOSITION, MIXTURE, USE OF A MONOCLONAL ANTIBODY OR A FUNCTIONAL PART OF THE SAME, METHOD FOR PREPARING A PHARMACEUTICAL COMPOSITION, ISOLATED HYBRIDOMA CELL LINING, A DAYTIME METHOD OF EMERGENCY TO DIAGNOSE A PREDISPOSITION FOR A DISEASE OR CONDITION, METHOD FOR MONITORING MINIMUM RESIDUAL DISEASE, METHOD FOR PREVENTING A PATIENT'S RESPONSIVENESS AND TEST KITS

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antibody, or an antigen-binding fragment thereof, conjugate, nucleic acid, vector, host cell, pharmaceutical composition, method of preparing an antibody light chain or antigen-binding fragment, and method of preparing a conjugate

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For intervening and treating congested anti-adrenomedulin (ADM) antibody or anti-ADM antibody fragment or the non-Ig bracket of anti-ADM of the patient of needs

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ISOLATED THERAPEUTIC HUMAN ANTIBODY OR ANTIGEN-BINDING PORTION THEREOF, ITS USE AND PRODUCTION PROCESS, PHARMACEUTICAL COMPOSITION, ISOLATED NUCLEIC ACID MOLECULE, CLONING OR EXPRESSION VECTOR AND TRANSGENIC MICRO-ORGANISM

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ANTI-HIL-2 ANTIBODY OR ANTIGEN BINDING FRAGMENT OF THE SAME AND ITS PRODUCTION METHOD, NUCLEIC ACID, RECOMBINANT VECTOR, TRANSFORMED CELL, COMPLEX, COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF ANTICORUS, ANTICOROUS, ANTIGOROUS COADMINISTRATION FOR CANCER TREATMENT AND COMPOSITION TO INCREASE VACCINE EFFECTIVENESS

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Method for predicting efficacy of anti-pd-1 antibody or anti-pd-l1 antibody therapy, method for evaluating cancer grade, and method for enhancing efficacy of anti-pd-1 antibody or anti-pd-l1 antibody therapy

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Monoclonal antibody or antigen-binding fragment for specifically inhibiting or alleviate the binding of ptx3 and ptx3 receptor and use of the same

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Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody

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METHOD FOR CONTROLLING THE CIRCULATION HALF-LIFE OF AN ANTIBODY OR A FRAGMENT OR FUNCTIONAL DERIVATIVE THEREOF, ANTIBODY COMPOSITIONS, THEIR USES AND THEIR PRODUCTION METHODS

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Isolated bivalent antibody or bivalent fragment thereof, which acts on lrp6 enhancing a wnt signal by grouping one or more lrp6 receptors in the presence of a lrp6 binding protein; nucleic acid encoding it; vector comprising said nucleic acid; pharmaceutical composition comprising a multivalent anti-lrp6 antibody; and its use to treat cancer.

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Anti-Adrenomedullin (ADM) antibody or anti-ADM antibody fragment or an anti-ADM non-Ig scaffold for use in therapy

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Method for predicting efficacy of anti-PD-1 antibody or anti-PD-L1 antibody therapy, method for evaluating malignancy of cancer, and method for increasing efficacy of anti-PD-1 antibody or anti-PD-L1 antibody therapy

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy

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Human monoclonal antibody or a portion thereof, pharmaceutical composition containing thereof , DNA or a portion and vector containing thereof, cell and gene recombinant host

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Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy

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Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody

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Process for producing an antibody or antiserum, use of this process for obtaining mammalian cells which are capable of producing such an antibody, and use of the antibody or antiserum produced in this way for immunoassay

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isolated monoclonal antibody or antigen-binding fragment thereof that binds to cd8, pharmaceutical composition, nucleic acid molecule, expression vector, host cell, antibody conjugate, methods for imaging cd8-expressing tissue to treat a subject having a solid tumor, to predict a positive response to an anti-tumor therapy, to monitor a tumor response in a subject to an anti-tumor therapy, to predict or monitor the effectiveness of anti-tumor therapy, and to monitor the presence of t cells in a tumor over time, and, compound.

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TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF

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Treatment of atopic dermatitis employing anti-il-13r?1 antibody or binding fragment thereof

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Treatment of atopic dermatitis employing anti-il-13r?1 antibody or binding fragment thereof

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Conjugate between antibody or peptide and phthalocyanine dye

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An antibody or antibody fragment-targeted cationic immunolysome complex and methods of preparing the same

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Antibody or antibody fragment-targeted cationic immunolysome complex and methods of preparing the same

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ANTI TGF-ß 1 ANTIBODIES OR ANTIGEN BINDING FRAGMENTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USE THEREOF FOR THE MANUFACTURE OF MEDICAMENTS FOR TREATING FIBROTIC DISEASES

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Medicinal composition containing monoclonal antibody or antibody fab fragment thereof, and use thereof

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Medicinal composition containing monoclonal antibody or antibody fab fragment thereof, and use thereof

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Stable aqueous formulation of an anti-adrenomedullin (adm) antibody or anti-adm antibody fragment

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Vaccine comprising an angiomotin or a polynucleotide encoding an angiomotin and its uses for the treatment of angiogenic-related disorders

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Composition, containing rgd motif-containing peptide or fragment thereof, for treating burns and glaucoma, alleviating skin wrinkles, and promoting hair growth

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Composition, containing RGD motif-containing peptide or fragment thereof, for treating burns and glaucoma, alleviating skin wrinkles, and promoting hair growth

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recombinant antibody or antigen-binding fragment thereof, pharmaceutical composition and kit comprising said antibody, methods of detecting troponin i antigen in a test sample and in vitro methods of diagnosing acute coronary syndrome or myocardial infarction in a patient

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Kit for producing a crosslinked gel for surrounding urinary calculi and/or fragments thereof

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Bridging the sulphur atom of antigen, antibody or fragments to a substrate

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METHODS TO TREAT MUCOPOLYSACCHARIDE TYPE II OR DEFICIENCY IN IDURONATE-2-SULFATASE USING A RECOMBINANT ADENO-ASSOCIATED VIRUS ENCODING IDURONATE-2-SULFATASE

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Recombinant Virus Encoding Glutamate Dicarboxylase (GAD) Activity

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Chimeric or humanized antibody or fragment thereof that specifically bind to at least one epitope in the beta-amyloid protein; nucleic acid molecule that encodes it; composition that includes it; and its use to treat diseases associated with the formation of amyloid plaques.

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COMPOUND, RADIOPHARMACEUTICAL FORMULATION, PHARMACEUTICAL COMPOSITION, USE OF COMPOUND, MIXTURE, METHODS OF COLLECTING DATA FOR THE DIAGNOSIS OF A DISEASE OR CONDITION ASSOCIATED WITH AMYLOID, OF DETERMINING THE EXTENSION OF AMYLOIDOGENIC CARGO OF PLACAS, AND/OR FLUID IN A MATCH COLLECTING DATA TO DETERMINE A PREDISPOSITION TO A DISEASE OR CONDITION ASSOCIATED WITH AMYLOID IN A PATIENT, TO COLLECT DATA TO MONITORING THE MINIMUM RESIDUAL DISEASE IN A PATIENT FOLLOWING TREATMENT WITH AN ANTIBODY OR A VACCINE COMPOSITION, TO COLLECT DATA OF A PATIENT BEING TREATED WITH AN ANTIBODY OR A VACCINE COMPOSITION, AND, TEST KIT

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antibody or antigen binding fragment thereof, combination comprising them, method of detecting rsv infection, nucleic acid molecules, and method of producing an antibody or antigen binding fragment thereof

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Methods, antibodies or antigen binding fragments and other tools for determining target molecules

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Anti-8-hydroxy-2'-deoxyguanosine antibody or antibody fragment thereof, production method, kit, measuring method, and device for measurement

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Sars-cov-2 immunoassay method and immunoassay kit, and monoclonal antibody or antibody fragment thereof

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Method for stabilizing analyte structure using antibodies or antibody fragments thereof

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Sars-cov-2 immunoassay method and immunoassay kit, and monoclonal antibody or antibody fragment thereof

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