Antibody binding superficial zone protein and their uses in diagnosis and screening methods
Номер патента: WO2001058958A9
Опубликовано: 17-10-2002
Автор(ы): Barbara L Schumacher, Jeff T Hutchins, Jui-Lan Su, Kathryn Mason Lindley, Klaus E Kuettner, Stephen Anthony Stimpson, Thomas M Schmid
Принадлежит: Barbara L Schumacher, Glaxo Group Ltd, Jeff T Hutchins, Jui-Lan Su, Kathryn Mason Lindley, Klaus E Kuettner, Rush Presbyterian St Luke, Stephen Anthony Stimpson, Thomas M Schmid
Опубликовано: 17-10-2002
Автор(ы): Barbara L Schumacher, Jeff T Hutchins, Jui-Lan Su, Kathryn Mason Lindley, Klaus E Kuettner, Stephen Anthony Stimpson, Thomas M Schmid
Принадлежит: Barbara L Schumacher, Glaxo Group Ltd, Jeff T Hutchins, Jui-Lan Su, Kathryn Mason Lindley, Klaus E Kuettner, Rush Presbyterian St Luke, Stephen Anthony Stimpson, Thomas M Schmid
Реферат: The invention provides an antibody or a fragment thereof having specific binding affinity for superficial zone protein (SZP) or a variant, fragment, or protein core thereof, wherein the binding affinity of the antibody or fragment thereof for human superficial zone protein is the same or greater than the binding affinity for bovine superficial zone protein in a competitive binding assay, IAsys analysis, or BIAcore analysis. The present invention further provides hybidoma cells that produce the monoclonal antibody and antibody reagent kits comprising the antibody or fragment of the invention. Further provided by the invention are methods of SZP detection, methods of diagnosing a degenerative joint condition, and screening methods related to the use of the antibody or fragment thereof.
Antibody binding specifically to human and mouse l1cam protein, and use therefor
Номер патента: US20150344571A1. Автор: Singh Rohit,Hyo Jeong Hong,In Soo Park,Seul Ki Cho,Mun Sik Jeong. Владелец: University Industry Cooperation Foundation of Kangwon National University. Дата публикации: 2015-12-03.