Compounds, compositions and method suitable for amelioration of withdrawal syndromes and withdrawal-induced brain damage
Номер патента: EP1011676A1
Опубликовано: 28-06-2000
Автор(ы): Boris Tabakoff, Lawrence Snell, Paula L. Hoffman
Принадлежит: Lohocla Research Corp
Опубликовано: 28-06-2000
Автор(ы): Boris Tabakoff, Lawrence Snell, Paula L. Hoffman
Принадлежит: Lohocla Research Corp
Реферат: Compounds, compositions and method for ameliorating alcohol or drug dependency withdrawal syndromes and withdrawal-induced brain damage are disclosed. In particular, a series of N-substituted-4-ureido-5,7-dihalo-2-carboxy quinoline compounds are disclosed having combined properties as antagonists of voltage-sensitive sodium channels (VSNaC) and as selective competitive antagonists at the strychnine-intensive glycine site of N-methyl-D-aspartate (NMDA) receptors. The disclosed compounds prevent or reduce the signs and symptoms of neurohyperexcitability and particularly the neurohyperexcitability associated with withdrawal syndrome manifested by patients upon withdrawal from chronic use of dependence inducing agents (e.g, ethanol, barbiturates, opiates etc.). The combined actions of the disclosed compounds on VSNaC and NMDA receptors also impart properties to these compounds that are important in preventing and reducing excitotoxic neurodegeneration and reducing anxiety without the undesirable CNS depressant side-effects of agents hitherto employed for these purposes.
Compounds, compositions and method suitable for amelioration of withdrawal syndromes and withdrawal-induced brain damage
Номер патента: EP1011676A4. Автор: Boris Tabakoff,Lawrence Snell,Paula L Hoffman. Владелец: Lohocla Research Corp. Дата публикации: 2004-08-11.