Plasmid stabilisation in vivo
Номер патента: AU2003232336A1
Опубликовано: 02-12-2003
Автор(ы): Julian Hanak, Rocky Cranenburgh, Scott Gorman
Принадлежит: Cobra Therapeutics Ltd
Опубликовано: 02-12-2003
Автор(ы): Julian Hanak, Rocky Cranenburgh, Scott Gorman
Принадлежит: Cobra Therapeutics Ltd
Реферат: This invention provides in vivo methods of maintaining a plasmid within a host cell, which is in turn within a recipient organism. In particular it relates to methods of maintaining a plasmid containing a gene useful in therapy, especially vaccination. The invention is based on modified host cells, suitable for in vivo therapeutic use, that may be used to express a therapeutically useful plasmid-borne gene, using a plasmid maintenance system that does not require the use of a plasmid-borne dominant selectable marker, but rather utilises a system of repressor titration. Methods of selecting host cells comprising the plasmid and host cells for use in these methods are also provided.
Plasmid stabilisation in vivo
Номер патента: EP1507863A1. Автор: Julian Cobra Therapeutics Limited Hanak,Rocky Cobra Therapeutics Limited Cranenburgh,Scott Pharmaventures Limited Gorman. Владелец: Cobra Therapeutics Ltd. Дата публикации: 2005-02-23.