Meganuclease variants cleaving a dna target sequence from a rag gene and uses thereof
Номер патента: EP2046950A2
Опубликовано: 15-04-2009
Автор(ы): Sylvain Arnould, Sylvestre Grizot
Принадлежит: CELLECTIS SA
Опубликовано: 15-04-2009
Автор(ы): Sylvain Arnould, Sylvestre Grizot
Принадлежит: CELLECTIS SA
Реферат: An I-CreI variant, wherein one of the I-CreI monomers has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG core domain situated respectively from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from a RAG gene. Use of said variant and derived products for the prevention and the treatment of a SCID syndrome associated with a mutation in a RAG gene.
Meganuclease variants cleaving a dna target sequence from the human lysosomal acid alpha-glucosidase gene and uses thereof
Номер патента: WO2011021166A1. Автор: Jean-Pierre Cabaniols. Владелец: CELLECTIS. Дата публикации: 2011-02-24.