Use of carboxypeptidase g for combating antifolate toxicity
Номер патента: EP1727548A2
Опубликовано: 06-12-2006
Автор(ы): Anthony Morvus Technology Limited ATKINSON, Roger Morvus Technology Limited MELTON
Принадлежит: Protherics Medicines Development Ltd
Опубликовано: 06-12-2006
Автор(ы): Anthony Morvus Technology Limited ATKINSON, Roger Morvus Technology Limited MELTON
Принадлежит: Protherics Medicines Development Ltd
Реферат: A method of combating toxicity caused by an antifolate compound of Formula: (I), in an individual who has been administered the compound. The method comprises administering an enzyme that has carboxypeptidase G activity to the individual. A method of cleaving a compound comprising a structural fragment of Formula: (VIII), the method comprising contacting the compound comprising the structural fragment of Formula: (VIII) with an enzyme that has carboxypeptidase G activity.
Use of carboxypeptidase g for combating antifolate toxicity
Номер патента: CA2557610A1. Автор: Anthony Atkinson,Roger Melton. Владелец: Individual. Дата публикации: 2005-09-15.