Preparation of a trans-calanolide ketone intermediate and chiral separation of calanolide alcohols to give racemic calanolide a
Номер патента: EP1597263A1
Опубликовано: 23-11-2005
Автор(ы): Edward D. Daugs
Принадлежит: Dow Global Technologies LLC
Опубликовано: 23-11-2005
Автор(ы): Edward D. Daugs
Принадлежит: Dow Global Technologies LLC
Реферат: The method of the invention comprises a process for synthesizing a trans-calanolide A ketone intermediate used in the synthesis of racemic trans-calanolide A. The invention further comprises a method for removing a racemic calanolide B diastereomer from a mixture of calanolide A and calanolide B diastereomers formed in the last step of the synthesis of calanolide A by crystallization.
Process for the preparation of an n-(2-bromoalkyl)-amide derivate_______________________________________________________________
Номер патента: WO1997000237A1. Автор: Quirinus Bernardus Broxterman,Henricus Leonardus Marie Elsenberg,Gerardus Karel Maria Verzijl. Владелец: Dsm N.V.. Дата публикации: 1997-01-03.