Process for producing of 4-(2-methoxyethyl)-phenylglycidyl ether and/or metoprol
Номер патента: AU5326986A
Опубликовано: 21-08-1986
Автор(ы): Arthur Friedrich Marx, Brian William Robertson, Gareth Thomas Phillips, Hein Simon Koger, Mauro Attilio Bertola, Peter Douglas Watts
Принадлежит: Gist Brocades NV, Shell Internationale Research Maatschappij BV
Опубликовано: 21-08-1986
Автор(ы): Arthur Friedrich Marx, Brian William Robertson, Gareth Thomas Phillips, Hein Simon Koger, Mauro Attilio Bertola, Peter Douglas Watts
Принадлежит: Gist Brocades NV, Shell Internationale Research Maatschappij BV
Реферат: A process for the preparation of metoprolol in a stereospecifice form or a pharmaceutically acceptable salt thereof like an acid addition salt, and/or a stereospecific form of 4-(2-methoxyethyl)-phenylglycidyl ether which comprises subjecting 4-(2-methoxyethyl)-phenylallyl ether to the action of a micro-organism having the ability for stereoselective epoxidation of 4-(2-methoxyethyl)-phenylallyl ether into 4-(2-methoxyethyl)-phenylglycidyl ether, having at least 80% by weight the S configuration, at least partly separating 4-(2-methoxyethyl)-phenylglycidyl ether with isopropylamine and at least partly separating metoprolol and/or converting metoprolol into the pharmaceutically acceptable salt thereof.
Process for producing of 4-(2-methoxyethyl)-phenylglycidyl ether and/or metoprol
Номер патента: AU593232B2. Автор: Mauro Attilio Bertola,Arthur Friedrich Marx,Hein Simon Koger,Gareth Thomas Phillips,Brian William Robertson,Peter Douglas Watts. Владелец: Gist Brocades NV. Дата публикации: 1990-02-08.