Pre-surgical risk stratification based on pde4d7 and dhx9 expression
Опубликовано: 18-08-2021
Автор(ы): George Baillie, Ralf Dieter HOFFMANN
Принадлежит: Koninklijke Philips NV, University of Glasgow
Реферат: The invention relates to a method of pre-surgical risk stratification of a prostate cancer subject, comprising determining a gene expression profile for phosphodiesterase 4D variant 7 (PDE4D7) in a biological sample obtained from the subject, determining a gene expression profile for DExH-box helicase 9 (DHX9) in the same or another biological sample obtained from the subject, and determining a pre-surgical prognostic risk score for the subject based on the gene expression profile for PDE4D7 and the gene expression profile for DHX9. This may allow for an improved stratification of the subject in a pre-surgical setting that may result in better primary treatment decisions. For instance, the pre-surgical prognostic risk score may allow to make better recommendations on whether to select active surveillance vs. active intervention, e.g., radical prostatectomy, for certain sub-populations of prostate cancer patients.
Pre-surgical risk stratification based on pde4d7 and dhx9 expression
Номер патента: WO2020074679A1. Автор: George Baillie,Ralf Dieter HOFFMANN. Владелец: KONINKLIJKE PHILIPS N.V.. Дата публикации: 2020-04-16.