Bioconjugate comprising a photosensitizer unit, method for its preparation and use thereof
Номер патента: EP4284433A1
Опубликовано: 06-12-2023
Автор(ы): Elisabeth Garanger, José Antonio GONZALEZ-DELGADO, Sébastien Lecommandoux, Tomás TORRES-CEBADA, Vusala IBRAHIMOVA
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Institut Polytechnique de Bordeaux, Universidad Autonoma de Madrid, Universite de Bordeaux
Опубликовано: 06-12-2023
Автор(ы): Elisabeth Garanger, José Antonio GONZALEZ-DELGADO, Sébastien Lecommandoux, Tomás TORRES-CEBADA, Vusala IBRAHIMOVA
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Institut Polytechnique de Bordeaux, Universidad Autonoma de Madrid, Universite de Bordeaux
Реферат: The invention relates to a bioconjugate comprising a photosensitizer unit, in particular a phthalocyanine unit, and an elastin-like polypeptide conjugated thereto, said elastin-like polypeptide containing at least one occurrence of a monomeric unit having the formula Xaa1PXaa2Xaa3G, wherein P represents a prolyl residue, G represents a glycyl residue, Xaa2 represents a glycyl residue or an alanyl residue and either Xaa1 represents a valyl residue and Xaa3 represents a sulfur-containing amino acid residue having a side chain of formula –(CH2)z-S- R' or Xaa3 represents a valyl residue and Xaa1 represents a sulfur-containing amino acid residue having a side chain of formula –(CH2)z-S-R'. This bioconjugate proves particularly useful for the treatment of diseases by photodynamic therapy.
Method for microencapsulation of sertoli cells, produced microcapsules and use thereof for preventing and treating sugar diabetes type 1
Номер патента: RU2598736C2. Автор: Риккардо КАЛАФЬОРЕ,Джованни ЛУКА,Марио КАЛЬВИТТИ,Эннио БЕККЕТТИ,Паоло ПУЧЧЕТТИ,Франческа ФАЛЛАРИНО,Клаудио НАСТРУЦЦИ. Владелец: ДжиЭйч Кэа Инк. д/б/а ЭЛТУЦЕЛЛ ИНК.. Дата публикации: 2016-09-27.