Metal impact on manufacturing of alkaline phosphatases
Номер патента: EP3464573A1
Опубликовано: 10-04-2019
Автор(ы): Anne Kantardjieff, Jared Davis, Rachael Alford, Saravanamoorthy Rajendran, Sean Gallagher
Принадлежит: Alexion Pharmaceuticals Inc
Опубликовано: 10-04-2019
Автор(ы): Anne Kantardjieff, Jared Davis, Rachael Alford, Saravanamoorthy Rajendran, Sean Gallagher
Принадлежит: Alexion Pharmaceuticals Inc
Реферат: The disclosure provides a method of producing recombinant alkaline phosphatase comprising: (i) culturing an alkaline phosphatase in a recombinant cell culture; (ii) obtaining a preparation of recombinant alkaline phosphatase from the cell culture; and (iii) minimizing in the preparation a concentration of at least one metal ion selected from the group consisting of: Nickel (Ni), Cobalt (Co), Copper (Cu), Manganese (Mn), Chromium (Cr), and Molybdenum (Mo).
Metal impact on manufacturing of alkaline phosphatases
Номер патента: US20200224182A1. Автор: Sean Gallagher,Saravanamoorthy Rajendran,Jared Davis,Anne Kantardjieff,Rachael Alford. Владелец: Alexion Pharmaceuticals Inc. Дата публикации: 2020-07-16.