Adhesive hydrogels having extended use lives and process for the preparation of same
Номер патента: CA2123487A1
Опубликовано: 27-05-1993
Автор(ы): Adrian S. Fox, Christine A. Czap, Robin R. Wiser
Принадлежит: Individual
Опубликовано: 27-05-1993
Автор(ы): Adrian S. Fox, Christine A. Czap, Robin R. Wiser
Принадлежит: Individual
Реферат: This invention relates to a non-stringy adhesive hydrophilic gel comprising an aqueous mixture of a radiation crosslinkable water-soluble polymer, at least one humectant effective to extend the moisture retaining characteristics of the gel and which inhibits the ability of radiant energy to crosslink the water-soluble polymer, a pharmacologically active agent, and a crosslinking promoter effective to counteract the crosslinking inhibitory effect of humectant. The aqueous mixture is exposed to radiant energy effective to provide a non-stringy adhesive cohesive homogeneous hydrophilic gel that has an extended in-use lifetime. The gels can be formed into PATCHES for long term application of the pharmacologically active agent to a patient.
Processes and intermediate for the large-scale preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate, and preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide acetate
Номер патента: ZA202303699B. Автор: David Andrew Coates,Scott Alan Frank,Aktham Aburub,Roger Ryan Rothhaar,Radhe Krishan Vaid,Mark Steven Kerr. Владелец: ELI LILLY AND COMPANY. Дата публикации: 2024-09-25.