02-06-2022 дата публикации
Номер: US20220169595A1
Принадлежит:
Disclosed are methods for preparing deuterated analogs of D-serine and compounds useful for preparing deuterated analogs of D-serine. 2. The method of claim 1 , wherein in the compound of Formula E claim 1 , Ris C-Calkyl.3. The method of or claim 1 , wherein Ris isopropyl or t-butyl.4. The method of any of - claim 1 , wherein Ris a protecting group.5. The method of any of - claim 1 , wherein Ris a protecting group selected from —C(O)H claim 1 , —C(O)—X—C-Calkyl claim 1 , —C(O)—X—C-Ccycloalkyl claim 1 , —C(O)—X—CH-aryl claim 1 , —C(O)—X-aryl claim 1 , —CH-aryl claim 1 , wherein X is absent claim 1 , O claim 1 , NH claim 1 , or S.8. The method of any of - claim 1 , wherein the acid is HCl.11. The method of any of - claim 1 , wherein the step of contacting the second reaction mixture with a base comprises contacting the second reaction mixture with 1-10 equivalents of lithium deuteroxide.13. The compound of claim 12 , wherein Ris H.14. The compound of claim 12 , wherein Ris a protecting group selected from the group consisting of —C(O)H claim 12 , —C(O)—X—C-Calkyl claim 12 , —C(O)—X—C-Ccycloalkyl claim 12 , —C(O)—X—CH-aryl claim 12 , —C(O)—X-aryl claim 12 , —CH-aryl claim 12 , —S(O)—C-Calkyl claim 12 , and S(O)-aryl claim 12 , wherein X is absent claim 12 , O or NR claim 12 , wherein Ris H or C-Calkyl.15. The compound of claim 14 , wherein Ris a protecting group selected from the group consisting of —C(O)H claim 14 , —C(O)—X—C-Calkyl claim 14 , —C(O)—X—C-Ccycloalkyl claim 14 , —C(O)—X—CH— aryl claim 14 , —C(O)—X-aryl claim 14 , —S(O)—C-Calkyl claim 14 , and S(O)-aryl claim 14 , wherein X is absent claim 14 , O or NR claim 14 , wherein Ris C-Calkyl.17. The compound of claim 16 , wherein{'sup': '3', 'sub': 1', '6', '3', '6, 'Ris H, D, —C(O)—X—C-Calkyl, —C(O)—X—C-Ccycloalkyl, —C(O)—X-aryl, wherein X is absent, O, NH, or S.'}19. The method of claim 18 , wherein the base is selected from mesityllithium claim 18 , 2 claim 18 ,6-dimethoxyphenyllithium claim 18 , 2 claim 18 ,4 ...
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