COMPOSITION COMPRISING RADIX REHMANNIAE PREPARATA EXTRACT FOR PROMOTING SYNTHESIS OF HYALURONIC ACID AND USE THEREOF
The present invention refers to fatigue ( Furthermore, the present invention refers to said composition as an effective ingredient in the preventive or or joint support including pharmaceutical compositions for the treatment of, joint support and arthritis medicine external width composition for treatment or prevention, is directed to or food composition containing them. Furthermore, the present invention refers to said composition for promoting generation hyaluronic acid as an effective ingredient including skin elasticity, aging prevention, or cosmetic composition for treatment or for inhibiting wrinkles, or food composition containing them; or medicament for treatment of or for inhibiting wrinkles is directed to compositions. Furthermore, the present invention refers to said composition for promoting generation hyaluronic acid as an effective ingredient cosmetic composition for skin moisturizing including, medicine external width or food composition is directed to compositions. Hyaluronic acid (hyaluronic acid) [...] in kind of the glycosaminoglycan (glycosaminoglycans) N-acetylglucosamine residues is connected repeatedly material that has polysaccharide polymer-shaped the chains. Major amounts of water in combination with high viscosity is made gel properties have a and elastomer. An extracellular hyaluronic acid of the substrate major component the, water retention, maintaining distance that is able to cells, growth factor and nutrition components for storing as well as the ms is engaged diffusion, differentiation and having a narrow distribution cells, mobile-proof packing and which are involved in the reported bar to. Hyaluronic acid joint that attempt to protect the joint of the fiber capillary gun oceansynovia main constituent, is secreted from fibro (fibrolast-like synoviocytes) cells. For lubricating the joint hyaluronic acid to the tip, and serves to, hyaluronic acid component reduction osteoarthritis occurrence cause one of, thereby shock absorption capability joint the numb articulated, are reduced and the discomfort is carried out, the amount of walking. Hyaluronic acid in joints from the outside during a joint and absorbing external impulse or dispersing a joint damage through the can be-dried to is. Synovial in hyaluronic acid concentration of hyaluronic acid synthase (hyaluronic acid synthase, HAS) hyaluronic acid creation and a hyaluronic acid by protease (Hyaluronidase, HYAL) a hyaluronic acid by is determined by. Degenerative arthritis patient and rheumatoid arthritis in patients in fibro reduced expression of HAS-2 and HAS-1, expression of HYAL-2 for the color temperature. (Arthritis Res Ther, 2004,6, R514-R520). In skin while, mammalian interior regions of 50% or more of hyaluronic acid present in the skin, in particular skin cells of distributed tissue engage of dermis and space it been reported, such hyaluronic acid mainly keratinocyte and fibroblast synthesized by a. are known to be. The amount of hyaluronic acid in human skin area decreases with aging been reported to, within the skin and the skin elasticity according to aging reduction of hyaluronic acid for reduction of moisture content and cause direct of wet liquid to flow down is considered a one (Biochem Biophys Acta 279,265-275 ; Carbohydr Res 159,127-136 ; Int J Dermatol 33,119-122). Stratum corneum hyaluronic acid in addition structure of maintaining skin barrier function can be maintained and at the same the receiver extracts the constitution: known to barge (J Cosmet Dermatol. 2007 Jun, 6 (2), 75-82). However, such as said food hyaluronic acid for a preservative or an combines are moved to the outside by the absorption is not well. Furthermore, a hyaluronic acid for mitigation of rheumatoid arthritis injected into joint method is American years notches at the currently FDA in 1997 is fixed by attaching the Velcro tape procedures, ultimately arthritis hyaluronic acid the body a Neo-femoral constitution increasing the synthesis method is more efficient to. Thus increase generation of hyaluronic acid in body which can be and drinks are a higher melting method but either progressing, watching eagerly both in the dynamics in vivo research yet are provided which is known. Under such background, the present inventor are the body a Neo-femoral hyaluronic acid synthesis, substances capable of increased to exploit effort results, fatigue ( Fatigue which is the object to of the present invention ( It is another object of the present invention said composition including joint support and arthritis as an effective ingredient composition for preventing or treating by a rope.. Another object of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient including skin elasticity, aging prevention, or for treatment or for inhibiting wrinkles by a rope. composition. Another object of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient including skin moisturizing composition is provided by a rope.. Another object of the present invention said cosmetic composition composition, food composition, pharmaceutical composition and medicine external width composition from a material selected from the group consisting of composition having a use of by a rope.. Another object of the present invention said composition fractions extracts or their fatigue contrast total weight of the weight % to 0.00001 to 10 provides compositions including by a rope.. Fatigue which is the object to of the present invention ( It is another object of the present invention said composition as an effective ingredient in the preventive or or joint support including pharmaceutical compositions for the treatment of, joint support and arthritis medicine external width composition for treatment or prevention, by a rope. composition or food. Another object of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient including skin elasticity, aging prevention, or cosmetic composition for treatment or for inhibiting wrinkles, or food composition containing them; or for inhibiting wrinkles provides pharmaceutical compositions for preventing or treating by a rope.. Another object of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient cosmetic composition for skin moisturizing including, medicine external width or food composition by a rope. composition. Said end of the, fatigue aspects of one of the present invention ( Terms of the present invention, "fatigue ( String and a previous number string, of the present invention to sold at the commercial hwang transmitted to the, an excellent or grown in contains thermoplastic resin, use can be made of, to. the "extract" of the present invention terms then subject to an extraction process to sulfur string and a previous number string, obtained by the extract, for extract of said dilution liquid or concentrate, and drying the resulting extract said a building, water purification or a coformulation adjusting for extract of said, or mixture of them on the, extract formed by using a extract per se and as well as all of the dosage form includes extracts. Specifically of the present invention said extract prepared dry powder after extraction can be used. Extract said, said plant of natural, hybrid or variants and can be extracted from plant, plant tissue culture. extraction are deselected. Fatigue extract said manufacturing method which is not limited the first substrate are assembled, the art using used to monitor the can be extracted, based on the method. Said extraction method for example, but not limited to, heat extraction, ultrasonic extraction, filtering method, such as extraction reflux of the radioactive part into contact with, these alone or at least one method which practices a 2 be. Furthermore, purity extract obtain any, extract such as in method 1 or more times at may be loaded with further extraction. Fatigue extract which are employed for the production of limited to, extracts of Barks of the kind of an extraction solvent confirmation, if the, the present purpose of the invention for obtaining the extract with capable any publicly known in the art, use can be made of, solvent. For example water, alcohol 1 to 4 carbon atoms, ethyl acetate, or chloroform one selected from the group consisting of, use can be made of, or more solvents. More specifically, use can be made of, as solvent ethanol. The terms "fraction" of the present invention a wide variety of components or certain particular constituent in a product from a mixture including for separating a group of elements for performing fractionation. a product obtained by. The method of preparing fractions fraction limited to, extracts of Barks of said confirmation, if the, the present purpose of the invention having the effect capable fractions used to monitor the art using can be is carried out according to method. For example, but not limited to said fraction method, string and a previous number string, fatigue extract in Hwang 20% by weight a predetermined fraction of the solvent method of preparing fractions from extract said :. The kind of solvent fraction limited to, extracts of Barks of said confirmation, if the, the present purpose of the invention with fractions capable any publicly known in the art, use can be made of, solvent. Said solvent fraction for example, but not limited to water, alcohol, ethyl acetate, or chloroform as to the aromatic hydrocarbon such as a solvent. They are 2 be used alone or in at least one can be is used mixed. Specifically, said water solvent fraction, alcohol 1 to 4 carbon atoms, ethyl acetate, acetone and chloroform selected from the group consisting of can be one or more, not limited to blood. The glycosaminoglycan (glycosaminoglycans) of the present invention terms "hyaluronic acid" [...] in kind of repeated N-acetylglucosamine residues are electronically coupled to each polysaccharide polymer-shaped the chains. material. One in the embodiment of the present invention in human derived patient degenerative arthritis in fibro gun ocean capillary fatigue extract concentration dependent fashion in hyaluronic acid generator thereby increasing the, glucosamine (positive the control group) than 100 100 200 times more similarly low amounts a hyaluronic acid synthesis by at least two types (table 2). Furthermore, degenerative arthritis in fibro gun ocean capillary human derived patient, fatigue extract hyaluronic acid synthase, can increase expression of HAS-3 and a in particular HAS-2 has been, glucosamine than the control group positive also low amounts 200 times more similar to precursor and CaO precursor cell growth rate by enhancing expression of HAS-2, higher HAS-3 expression dose to determining presence has been confirmed (table 3). Furthermore, normal human derived in fibro gun ocean capillary fiber, fatigue has been increase acid generating hyaluronic extract, glucosamine than 100 times more similarly low amounts a hyaluronic acid concentration for a difference from an has been confirmed (table 4). Furthermore, fatigue even intraluminal joint RAT generation increased the hyaluronic acid extract (table 5). The, fibro extract fatigue as well as cells excellent in intraluminal joint RAT in Said aspects of the other of the present invention as an effective ingredient composition for preventing or treating and arthritis joint support including provides pharmaceutical compositions. Said hyaluronic acid synthase (HAS) pharmaceutical compositions can be increasing the expression of. "Joint support" terms of the present invention for a variety of causes articulated thereby preventing damage to the meaning that it, that attempt to protect the joint hyaluronic acid since the main constituent, synovia, hyaluronic acid decreasing joint and absorbing external impulse or dispersing a joint through the osteoarthritis or damages arise can generate a salt. "Arthritis" terms of the present invention in relation to a variety of causes inflammatory to articulated so as to the meaning, decreasing hyaluronic acid may occur causing the arthritis. Specifically said osteoarthritis arthritis, degenerative arthritis, rheumatoid arthritis, fibrosis paragraph bottle spinal canal, spondylitis stiffness, psoriasis arthritis, ventilation, bacterial arthritis, pediatric to rheumatoid arthritis, lupus, scleroderma, and the, multiple sclerosis, fibromyalgia, multiple myositis, skin myositis, behcet, lighter syndrome, lime arthritis, [...] joint adhesion, 50 silk, tendon fibro salt, olecranon bag salt, the synovitis[...] tendons, rheumatoid recurrence, rheumatoid or fibromyalgia bundle may be bottle with caps on adult, more specifically degenerative arthritis or rheumatoid arthritis can be, is at. Fatigue in one in the embodiment of the present invention extract fibro gun ocean capillary human derived patient degenerative arthritis in hyaluronic acid concentration acid and hyaluronic acid synthase (HAS) gene of the number of the cell growth rate by enhancing expression of mRNA, intraluminal joint RAT cells and translocation normal to increase its concentration hyaluronic acid in the sliding member is has been confirmed (table 2 to 5). Hyaluronic acid which the joint lubricating the, hyaluronic acid the decrease of osteoarthritis can occur, a ceramic, a natural produce glitters know, hyaluronic acid generating excellent effect of promoting the in sulfur extracts or their fractions THon joint support and arthritis preventing or treating can be used effectively in. Pharmaceutical compositions of the present invention joint support and arthritis has at least preventing or treating various if % weight but also can be the same as, specifically fatigue extracts or their fractions relative to the total weight of pharmaceutical composition 0.00001 to 10 weight % .also can be the same as. the of the present invention terms "prevention" of suppressing or developing arthritis by administration composition all delay. behavior. Terms "treatment" of the present invention the treatment of a predisposed to develop high blood pressure already presenting the symptoms of arthritis all, to advantage or improving. behavior. Furthermore, pharmaceutical compositions contain conventional method according to of the present invention of suitable carrier, excipient number may further include any or diluents. A carrier may be included within the composition of the present invention, number and a diluent excipient include lactose, dextran [...], sucrose, sorbitol, mannitol, xylitol, Corynebacterium glutamicum cj88, maltitol, starch, rubber acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methyl hydroxy benzoate, profile hydroxy benzoate, talc, magnesium stearate and mineral oil, including but, is at. Method of the present invention according to pharmaceutical compositions contain conventional masked powders that are to be according to, number granules, purification, number capsule, suspension, emulsion, syrup, aerosols, and the like orally like dosage form, external number, a suppository or sterile injection in the shape of a solution formulated based. Specifically, be formulated when common filling number, number extender, coupled number, wetting, disintegrating, excipient or of a thinning agent surfactant can be formulated. Solid medicinal preparation is finished, the perfume ingredient for oral administration, bolus, masked powders that are to be, granules number, capsule number including an, such solid formulations number said compound at least one or more excipients, for example, starch, calcium carbonate, sucrose, lactose, gelatin is good for the Image recording agent is prepared. Furthermore, simple number excipients in addition to magnesium stearate, talc a lubricant, such as. may be used. Liquid formulations for parenteral administration include suspension number, content liquid, emulsion, syrup, including which number, the additive and water as the diluent a simple commonly used, in addition to paraffin liquid number various excipient, for example wetting, sweetener, aromatic, and preservatives may include. Agents are for parenteral administration in the sterilized aqueous solution, non-aqueous solvent, number suspension, emulsion, freeze-dried preparation and left system may be included. Non-aqueous solvent, suspension number include propylene glycol, polyethylene glycol, olive a vegetable oil, such as oil, includes a, ethyl [...] the scanning electrode and the ester can be or the like is used as an. [...] include base left proposal, macrogol glyceride, twin 61, carcass five fingers, does comprising lauric acid, glycero gelatin can be or the like is used as an. Pharmaceutical composition of the present invention the administered in an amount effective. Said pharmaceutical effective amount applicable to medical treatment through a rational will benefit/risk ratio unit and is sufficient a unit, device and method to side effects amount of initiator as not to cause a degree, effective capacity the level of a patient's health status, type of diseases, in the severity, drug action, sensitivity to drugs, administration method, administration time, route, and discharge ratio, therapy period, combination or simultaneously used the inhaler includes a mechanism to open a well-known to the field of elements and other medical can be determined according to factors. Per 1 kg weight of an individual administered specifically generally is 10.01 mg to 5000 mg, a physician or pharmacist of number 6 at first time for 11 times S101-S102 at constant time intervals may also be used but administering divided into, is at. Weight in male Sprague-Dawley Rat one in the embodiment of the present invention inside and outside the 200g (saM tachometer, Korean) fatigue to which the second photoresist layer is being as saline extract dilution to 100 or 500 mg per 1 kg weight RAT between 15 oral administration results for 11 times, the present invention according to normal RAT fatigue extract hyaluronic acid in intraluminal joint it is found out that increases the generation (in the embodiment 5). Furthermore, pharmaceutical compositions of the present invention alone or in joint support; or in the preventive or therapeutic effect other pharmaceutically active in combination with compounds or within in one set are angularly can be used. Furthermore, pharmaceutical compositions of the present invention the active substance is targeted cells any each of which may be movable RAT pharmaceutical compositions of the present invention, mouse, livestock, human such as the various pathway to mammals can be administered. Said any suitable administration method to a patient at a predetermined material provides meaning that it, the aim path of the present invention treatment of which can be reached tissue is not limited to a. Administration in joints for example, , either intraperitoneally administration, intravenous administration, intramuscular administration, subcutaneous administration, intradermally administration, oral administration, topical administration, nasally administering, intra-lung administration, rectal in but can be administered, are not limited to. Furthermore, the active substance is pharmaceutical compositions of the present invention each of which may be movable targeted cells any device may be administered to the patient by. Aspects of the other of the present invention said hyaluronic acid promoting generation composition including comprise administering to the individual, provides method preventing or treating arthritis. Terms "hyaluronic acid" of the present invention, "arthritis", "prevention", "treatment" and "administration" the taught equal. Said administration doses such as, frequency and administration are as the aforementioned route,. Email widow, a web page or of the present invention terms "individual", traveled said arthritis is predisposed to develop high blood pressure, including humans a likely to have the thus, the simian, bovine, horse, amount, porcine, chicken, turkeys, quail, CAT, two, mouse, RAT, rabbit or it is longoh the blood it will be wrong means all animals including, by administering acid composition to a subject of the present invention said diseases can be preventing or treating. Aspects of the other of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient for treatment or prevention and arthritis joint support including compositions for the medicine external width. Fatigue in one in the embodiment of the present invention extract fibro gun ocean capillary human derived patient degenerative arthritis in hyaluronic acid concentration acid and hyaluronic acid synthase (HAS) gene of the number of the cell growth rate by enhancing expression of mRNA, intraluminal joint RAT cells and translocation normal to increase the concentration hyaluronic acid in identifying improving can be (table 2 to 5) since the main frames are formed, including fractions extract or fatigue composition joint support and arthritis preventing or ameliorating can be used effectively in. Terms "hyaluronic acid" of the present invention, the "arthritis" and "preventing" said taught the same as the, the "improved" presenting the symptoms of arthritis by administration composition of the present invention beneficial or improving. behavior all easily changed. " medicine external width" of the present invention terms of the human or animal body, as well, reducing, treatment or preventing the fibers that are used for the purpose, using rubber product or the like, for the human body effect which or not acting directly on the human weak and/or corrupted, or machine not the and the like, wherein a sterilization for preventing infection, insecticidal in and the like corresponding to one of as an article in the formulation, a person or animal in the diagnosis of disease, treatment, relief, treatment or prevent a constitution: according to article mechanism, machine or device not the function structure and a person or animal and pharmacological adversely effect constitution: according to article mechanism, machine or device except for not the articles meaning, specifically skin external number or personal care article can be, is at. Fatigue extract or fractions joint support and arthritis prevention or amelioration when adding to medicine external width intended to, said second fractions extract or fatigue it has been deposited by either adding other medicine external width component and may be used in conjunction with, conventional method suitably according to, use can be made of,. Of active ingredient mixing amount according to the use purpose can be determined for. Said skin but not limited to specially continuously, for example number ointment, lotion number, now spreading, patch, cream number, masked powders that are to be, suspension number, prepared gel system or gel that includes a can be used. Said specially the personal care articles but not limited to, specifically soap, cosmetic, wet tissue, dormant, shampoo, skin creams, face cream, toothpaste, lipstick, perfume, makeup, foundation, it will see, mascara, for eyeshadow, sunscreen lotion, hair treatment product, may it will be a gel air [...] gel or cleaning. Furthermore, of the present invention medicine external widthclean sacrifice disinfecting in another example composition, shower foam, wet tissue, detergent soap, hand wash, mask or ointment agent. medicine external width composition joint support and arthritis of the present invention has at least preventing or ameliorating various if % weight but also can be the same as, specifically fatigue extracts or their fractions medicine external width 0.00001 to 10 weight % of the total weight of contrast also can be the same as.. Aspects of the other of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient including joint support and arthritis provides a food composition for treatment or prevention. Said string and a previous number string, is used for some time as natural products hwang regulates the proven stability, ars the copper tube is filled with joint support, and arthritis is improved parasitic infestations or for the prophylaxis of food is produced in the shape of a can be taken.. Fatigue in one in the embodiment of the present invention extract fibro gun ocean capillary human derived patient degenerative arthritis in hyaluronic acid concentration acid and hyaluronic acid synthase (HAS) gene of the number of the cell growth rate by enhancing expression of mRNA, intraluminal joint RAT cells and translocation normal to increase the concentration hyaluronic acid in identifying improving can be (table 2 to 5) since the main frames are formed, including fractions extract or fatigue composition joint support and arthritis preventing or ameliorating can be used effectively in. Terms "hyaluronic acid" of the present invention, "arthritis", "preventing" and "improved" the taught equal. Of the present invention terms "food" the meat, sausage, bread, chocolate, candy current, [...], confectionery, pizza, ramyon, other noodles, gum type, ice cream containing a dairy product, various sprocket, beverage, difference, abundant, alcohol beverage, vitamin complex, functional food and health is, foods, etc., in the conventional includes both food. Said rotation (functional food) functional food, food for specified health use, a (food for special health use, FoSHU) to a term the same, in addition suction pressure performing soft scroll function of vivo medical processing on efficient, medical second pattern is formed by a food.. Wherein "functional" photolithography of a human body nutrient to structural and functional physiological the handle, such as activity health which is useful for application effect.. Per the functional food of the present invention where a new file does not exist a typically used in producible by the method which, in the surveillance industry per active material is formed on said to add to conventional and materials component is added to precipitate out can be produced. In addition said notches at a functional foodstuff, in addition formulations functional foods have functional components formulations can be produced and without restriction, if. Food composition of the present invention various types of formulations can be manufactured, unlike drug generally food long-lasting administration in order to/or utilisation of various agents, to the exterior of body side effects the semiconductor substrate having the insulation layer is a free, anti portability, arthritis preventing or ameliorating of the present invention the functional food supporting auxiliary sound signals to the audio processor permits intake zero. Said health food (health food) compared to food is generally of a positive health maintenance or enhancement means food having, the aim composition and health supplementary has (health supplement food) health supplementary food. food. Optionally, functional food, health food, of health supplementary food can be mixed term. Specifically, post-treatment system said fatigue extracts or their fractions beverage, tea, spice, gum, confectionery foods such as it has been deposited by either adding material, encapsulated, powdered, suspension or the like manufacturing as a functional food for patients and, when the food to directly fix the capacitor to the a particular health but provide the means by which, unlike drug generally/or utilisation of various agents, to the exterior of body food long-lasting administration in order to the semiconductor substrate having the insulation layer unit is off without showing any side effects. Food composition of the present invention, a preservative or an-pro, having the activity of high input signal is inverted to be inputted can be protective boards joint support.. Furthermore, said composition remove odor and commonly used composition or a food composition, taste, extracts additional features which may be visual, a lamp, may include a component. For example, vitamin A, C, D, E, B1, B2, B6, B12, niacin (niacin), biotin (biotin), folate (folate), Pantothenic acid (panthotenic acid) such as may include a. Furthermore, zinc (Zn), iron (Fe), calcium (Ca), chromium (Cr), magnesium (mg), manganese (Mn), copper (cu), (Cr), and various minerals including [...] may include a. Furthermore, lysine, tryptophan, cysteine, valine, for example, exhibiting an amino acid may include a. Furthermore, said preservative composition (erythorbic acid potassium, sodium benzoic acid, salicylic acid, such as draw nitric acid natrium ), fungicides (highly bleaching powderbleaching powder, hypochlorous acid wave), antioxidant (butyl [...] (BHA), such as butyl [...] n (BHT)), colored number (tar can be easily adhered to the surface), chromophore (sodium nitrite, wave oh nitric acid ) number, bleach (sodium hydrosulfite), seasoning (MSG wave glutamic acid), sweetener ( it puts new, cycle [...], saccharin, wave), perfume (vanillin, such as lactone), expansion number (, and alum, such as potassium hydrogen-tartaric acid D), reinforcing agent, number emulsifier, thickener (drinkable), coating number, sword foundation system, foam inhibitors, solvent, improved additive foods such as number may include a (food additives). Said type of food additive is put on hold and appropriate in accordance with features of the images can be employed in an amount. Fatigue extracts or their fractions in food additives when used as an, eye fatigue or extracts or their fractions directly, and for preparing foods or food other it has been deposited by either adding can be used along with at, conventional method suitably according to can be used. A use purpose thereof for effective ingredient mixing tilted (prevention, health or therapeutic treatment of) according to can be determined for. Generally, in the manufacture of food or beverage to raw materials are food composition of the present invention hereinafter 15 parts by weight, specifically 10 parts by weight may be added amount of hereinafter.. The aim sanitary pad health and however when the intake for prolonged periods of time with said range may include content of hereinafter, with a fixing member of the back in the aspect of safety because of the absence of containing, as the active ingredient, an amount of at least said range can be used. Of the present invention of food composition in one example health drink composition is applied to, is over common wiring when drinks and such as number or natural carbohydrate or the like various flavor can additional components. The above-mentioned natural carbohydrate glucose, waste transfer crane of nuclear power mono such as raffinate; maltose, shoe cross and such as disaccharides; dextrin, cyclodextrin, such as the polysaccharide; xylitol, sorbitol, erythro [...] may it will be a party alcohol such as. Martin TAU sweetness system, Stevia extract and such as natural sweetener; saccharin, [...] such a synthetic sweetener, use can be made of, such as. Said natural carbohydrate composition of the present invention the ratio of 0.01 ∼ 0.04 g generally about per 100 ml, preferably about 0.02 ∼ 0.03 g is. Health beverage composition in addition to said various nutritional number, vitamin, electrolyte, flavor number, colored number, [...], [...] salt, alginate, alginate salts, organic acid, protective colloidal thickener, pH modulators, stabilizer, preservative, glycerin, alcohol such as a carbonaceous or agent can. Natural other as fruit juice, as fruit juice beverage, or for the production of vegetable beverage can matrix shape. These components move independently or can be used as a light-weight. Significant bits of the large ratio of these additives that it will not but 0.01-0.1 parts by weight of 100 parts by weight of a composition of the present invention which is selected from the range of is it is generally designated on a. Food composition joint support and arthritis of the present invention has at least preventing or ameliorating various if % weight but also can be the same as, specifically fatigue extracts or their fractions 0.00001 to 10 weight % relative to the total weight of food composition also can be the same as.. Aspects of the other of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient including skin elasticity, aging prevention; or for treating a skin wrinkle using preventing or ameliorating provides a cosmetic composition. The dermis layer of the present invention terms "skin elasticity" consisting of (elastin) elastin present resilient fiber on which a driving by, such resilient fibers such as rubber and has very low modulus, even with a small force is easily deformed, thereof is the force is removed is performed by circular easily when. Said elastin, collagen decreasing hyaluronic acid reflective skin elasticity. is. Of the present invention terms "skin aging" the skin metallurgical furnaces by elastically reduced, reducing radiance, wrinkle formation, severe attenuates or reproducibility will appear in symptoms of drying, time flow of or external environment in the music composition can be caused by, decreasing hyaluronic acid with decreased or skin elasticity is generated having wrinkles skin of hyaluronic acid. may be caused by a decrease. under iron is the skin of the present invention terms "for treating a skin wrinkle using" fine line which means that result from, a causal by gene, reduction of skin dermis for collagen present, external environment in the music composition can be caused by, elastin, collagen decreasing hyaluronic acid reflective for treating a skin wrinkle using is generated on. Fatigue in one in the embodiment of the present invention extract in keratinocyte derived from the human body to increase the concentration hyaluronic acid can be the n bit parallel data inputted identifying improving (table 6), water retention and increased of skin moisture of confirming very good capacity corresponding advertisement based on the shown list (table 7), optionally it comprises pigments and skin elasticity since of confirming the (table 8), skin elasticity, aging prevention, for inhibiting wrinkles or treatment can be for using effectively the. The terms "prevention" of the present invention said composition for treating a skin wrinkle using an effect of aging or by administration of suppressing or delay behavior all.. The "improved" of the present invention terms skin elasticity by administration composition of the present invention having wrinkles or skin beneficial or call. behavior all easily changed. Improvement in bounce/body cosmetic composition of the present invention, aging prevention, or for treating a skin wrinkle using preventing or ameliorating if be used various % weight but also can be the same as, specifically fatigue extracts or their fraction cosmetically 0.00001 to 10 weight % relative to the total weight material compositions also can be the same as.. Solution formulations of the cosmetic composition, external ointment, cream, foam, nutritional wash containing a crude drug, flexible wash containing a crude drug, perfume, pack, type research study, emulsion, makeup base, seat belt, soap, liquid cleansing, bathing number, ray screen cream, ray oil, suspension, emulsion, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, foundation emulsion, wax foundation, patch or spray can be, limited to blood not Said cosmetic composition to the deep core of the skin generally skin cosmetics dermatologically acceptable carrier 1 further may include at least one, for example with constituents of the conventional oil, water, surfactant, moisturizing number, lower alcohols, thickener, chelating number, inorganic salt, pigment, antioxidant, fungicides, preservative, but can be combined properly flavoured, limited to blood not. Said cosmetic dermatologically acceptable carrier, which carrier comprises said formulations of cosmetic composition according to.. Said formulations ointments, paste, cream or gel when the, carrier components as animal oil, vegetable oil, wax, paraffin, starch, estradiol Kant, cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc or a zinc oxide film can be degraded and is used as the, limited to blood not. They are be used alone or in mixed with at least one 2 can be used. An upper electrode is formed on or spray this powder formulations said, carrier components as lactose, talc, silica, aluminum hydroxide, calcium thread Kate, can be is used as the powder polyamide, in particular spray when the additionally chloro [...], propane/butane or dimethyl, such as a propellant can be degraded and, not limited to blood. They are be used alone or in mixed with at least one 2 can be used. When the emulsion solution or formulation said, carrier components as solvent, [...] agent or a dissolved can be is used as the agent, such as water, ethanol, isopropanol, ethyl polycarbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol can be is used as the oil, in particular, cotton seed oil, peanut oil, corn picks up oil, olive oil, comprising said hygroscopic sesame oil, an aliphatic ester glycerol, polyethylene glycol or sorbitan fatty acid esters can be used but, not limited to blood. They are be used alone or in mixed with at least one 2 can be used. When the suspension formulations are said, water as carrier principles, ethanol or propylene, such as glycol liquid of a thinning agent, ethoxylated ISO stearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan acid esters, such as the suspending number, microcrystalline cellulose, aluminum metadata seed hydroxy, bentonite, agar or estradiol can be degraded and is used as the Kant, limited to blood not. They are be used alone or in mixed with at least one 2 can be used. When the soap formulation of the present invention, carrier components as alkali metal salt of a fatty acid, fatty acid hemiesters salt, fatty acid protein [...], isethionates, lanolin derivatives, aliphatic alcohol, vegetable oil, glycerol, can be degraded and is used as the per, limited to blood not. They are be used alone or in mixed with at least one 2 can be used. Aspects of the other of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient including skin elasticity, aging prevention; or for treating a skin wrinkle provides a food composition for treatment or prevention. Terms "hyaluronic acid" of the present invention, "skin elasticity", "aging", "for treating a skin wrinkle using", "prevention", "improved" and "food" the taught equal. Fatigue in one in the embodiment of the present invention extract in keratinocyte derived from the human body to increase the concentration hyaluronic acid can be the n bit parallel data inputted identifying improving (table 6), water retention and increased of skin moisture of confirming very good capacity corresponding advertisement based on the shown list (table 7), optionally it comprises pigments and skin elasticity since of confirming the (table 8), skin elasticity, aging prevention, for inhibiting wrinkles or amelioration can be for using effectively the. Skin elasticity composition food of the present invention, aging prevention, for treating a skin wrinkle using preventing or ameliorating if be used various % weight but also can be the same as, specifically fatigue extracts or their fractions 0.00001 to 10 weight % relative to the total weight of food composition also can be the same as.. Aspects of the other of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient for inhibiting wrinkles including provides pharmaceutical compositions for preventing or treating. Terms "hyaluronic acid" of the present invention, "for treating a skin wrinkle using" and "prevention" the taught equal. Terms "treatment" of the present invention the treatment of skin wrinkle generated already, to advantage or is. all behavior. Fatigue in one in the embodiment of the present invention extract in keratinocyte derived from the human body to increase the concentration hyaluronic acid can be the n bit parallel data inputted identifying improving (table 6), water retention and increased of skin moisture of confirming very good capacity corresponding advertisement based on the shown list (table 7), optionally it comprises pigments and skin elasticity since of confirming the (table 8), skin elasticity, aging prevention, for inhibiting wrinkles or treatment can be for using effectively the. Pharmaceutical compositions of the present invention for inhibiting wrinkles or treatment if be used various % weight but also can be the same as, specifically fatigue extracts or their fractions relative to the total weight of pharmaceutical composition 0.00001 to 10 weight % .also can be the same as. Aspects of the other of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient including skin moisturizing cosmetic composition provides a. Hyaluronic acid of the present invention, said carrier and formulations of cosmetic composition taught equal. Of the present invention terms "moisturizing" moisture loss by the appropriate adaptation of the (performing water evaporation) or the like, as well as retaining the homeostasis of a living vertical frame, to, decreasing hyaluronic acid within the skin and the moisture is lost and, improving the hyaluronic acid having an. the resolution can be increased incrementally moisture. Fatigue in one in the embodiment of the present invention extract hyaluronic acid in keratinocyte derived from the human body to increase the concentration can be corresponding advertisement based on the shown list identifying improving (table 6), water retention and increased of skin moisture very good capacity since of confirming the (table 7), skin moisturizing can be used effectively in. Moisturizing cosmetic composition of the present invention be used various if % weight but also can be the same as, specifically fatigue extracts or their fraction cosmetically 0.00001 to 10 weight % relative to the total weight material compositions also can be the same as.. Aspects of the other of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient provides a skin moisturizing including the food break up. "Hyaluronic acid" of the present invention, "moisturizing" and "food" the taught equal. Fatigue in one in the embodiment of the present invention extract hyaluronic acid in keratinocyte derived from the human body to increase the concentration can be corresponding advertisement based on the shown list identifying improving (table 6), water retention and increased of skin moisture very good capacity since of confirming the (table 7), skin moisturizing can be used effectively in. Food composition of the present invention may indicate the cosmetic raw material having skin moisturizing effect various if % weight but also can be the same as, specifically fatigue extracts or their fractions 0.00001 to 10 weight % relative to the total weight of food composition also can be the same as.. Aspects of the other of the present invention said composition for promoting generation hyaluronic acid as an effective ingredient including medicine external width compositions for the skin moisturizing effect. "Hyaluronic acid" of the present invention, "moisturizing" and " medicine external width" the taught equal. Fatigue in one in the embodiment of the present invention extract hyaluronic acid in keratinocyte derived from the human body to increase the concentration can be corresponding advertisement based on the shown list identifying improving (table 6), water retention and increased of skin moisture very good capacity since of confirming the (table 7), skin moisturizing can be used effectively in. medicine external width of the present invention may indicate the cosmetic raw material having skin moisturizing effect composition if various % weight but also can be the same as, specifically fatigue extracts or their fractions medicine external width 0.00001 to 10 weight % of the total weight of contrast also can be the same as.. Fatigue extracts or their fractions THon hyaluronic acid generating acid and hyaluronic acid synthesizing enzyme effectively the motor, joint support, preventing or treating arthritis, skin elasticity, aging prevention, for inhibiting wrinkles or treatment, and is thus useful for the skin moisturizing and can be. Hereinafter, embodiment to the present constitution of the invention and effects, pulsating current is. described. Only relate these embodiment examples of the present invention of the present invention is for embodiment range and/or at least two different limited to not. Manufacturing example 1. Fatigue of processing for extracts of Embodiment to extract sulfur in used for the ethanolamine extract, from the, the third to eo m lap orbital [...]. In the embodiment 1. Cytotoxicity of extract fatigue evaluation Cytotoxicity of fatigue extract patient degenerative arthritis to assess an excellent human capillary gun ocean fibro cells (Human Fibroblast-like Synoviocyte, HFLS-OA, Cell Applications) Cell Counting Kit-8 change cell division of (Dojindo Lab, American) it was determined that using. First, a uniform number types of cells to 96 well plate the inner stabilizing and then then fatigue extract is processed so as to be is 5 or 10 PPM 24 the good additional time. After a peptide which specifically binds to CCK-8 2 behind time it was determined that in 450 nm absorbance. Fatigue contrast nothing control group (the control group) cell extract and cell survival relative analyzes together with the information rate, showed to result to the computer of the to table 1. = 3 can repeated* * Relative cell survival rate = (extract processing group) / ( nothing control group) X 100 Such as said table 1, cell processing extract fatigue nothing control group number of increasing rather than group measured under the different kind of processing and glucosamine could see he. The fatigue extract inducing cytotoxicity by a rope. suggesting into each other. In the embodiment 2. Degenerative arthritis patient by fatigue in fibro elevated level of hyaluronic acid Degenerative arthritis patient derived human capillary gun ocean the human body by cell translocation periosteum cell proliferation medium culturing the n bit parallel data inputted (Synoviocyte Growth Medium, Cell Applications), per well to 96-well plate 2.0x103 was mixed with one cell. After grown on between 3, human periosteum cell proliferation medium is exchanged with the n bit parallel data inputted l micro 200, by concentration fatigue extract (10 PPM and 5) added to. Voice the control group equal amount of ethanol processing the n bit parallel data inputted, positive the control group in hyaluronic acid stimulate cytokine production known a glucosamine hydrochloride (Glucosamine hydrochloride, Sigma-aldrich). 24 1000 PPM a culture nor post-incubation time was filtered, is recovered and allowed to cell culture Hyaluronan ELISA kit (R & D Systems) hyaluronic acid using showed to measure a concentration table 2. = 4 can repeated* * Voice the control group of hyaluronic acid concentration reference (100%) in fatigue extract and the cells to a type used in groups into a number by hyaluronic acid concentration As a result, fatigue extract concentration dependent fashion in degenerative arthritis patient's translocation generation increased the hyaluronic acid in cells. The control group than benign extract fatigue in addition 100 100 200 times more similarly low amounts revealed a a hyaluronic acid concentration. The, fatigue in translocation patient's degenerative arthritis extract hyaluronic acid promoting generation optionally it comprises pigments and of confirming the leg unit located between a main, joint support and arthritis useful in the prevention or treatment of can be used. In the embodiment 3. Fatigue in translocation patient degenerative arthritis by hyaluronic acid synthase (HAS)increased expression of gene Degenerative arthritis patient derived human capillary gun ocean fibro periosteum the human body by cells improves cell proliferation between the division 6-well plate 3 after grown on, and exchanging medium fatigue concentration of 10 PPM 24 extract was filtered time. The supernatant may be processed to recover cells, RNeasy mini kit (Qiagen) behind are extracted total RNA, a RNA of g micro 1 accurately GeneAmp® RNA PCR kit (Applied Biosystems) using the (reverse transcription) reverse transcriptase. Reverse transcriptase reaction is Mycycler® PCR device using performed for all the (Biorad). L micro 2 reaction solution after reverse transcriptase HAS-2 and a, HAS-3, GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) of Taqman® probe (Invitrogen, American, Hs00193435 _ m1, Hs00193436 _ m1) quantitative real time PCR is performed for all the using. The Real time PCR CFX96 TouchTM Real-Time PCR Detection System device using performed for all the (Biorad). Obtainable from the Real time PCR (housekeeping) gene GAPDH housekeeping house experiments Livak K based on a. J. Addition (Methods, 2001, 25, 402-408) is showed by performing open method. Furthermore, voice the control group of reference cell growth rate by enhancing expression of mRNA (100%) on extract processing experiment groups fatigue and the possibility of expression amount mRNA showed to 3 the table. = 4 can repeated* As a result, fatigue extract subjecting the film to a treatment by fibro patient's degenerative arthritis in hyaluronic acid synthase, in particular HAS-2 expression of HAS-3 and a up. Furthermore, fatigue extract benign contrast 200 times more soldiers glucosamine processing than the control group positive also low amounts HAS-2 similar to cell growth rate by enhancing expression of precursor and CaO precursor, showed higher HAS-3 expression dose. The, fatigue extract in translocation patient's degenerative arthritis increasing the expression of synthase hyaluronic acid optionally it comprises pigments and of confirming the leg unit located between a main, joint support and arthritis useful in the prevention or treatment of can be used. In the embodiment 4. Normal translocationby fatiguein elevated level of hyaluronic acid The human body by cell translocation human capillary gun ocean periosteum cell proliferation medium culturing the n bit parallel data inputted (Synoviocyte Growth Medium, Cell Applications), per well to 96-well plate 2.0x103 was mixed with one cell. After grown on between 3, human periosteum cell proliferation medium is exchanged with the n bit parallel data inputted l micro 200,10 PPM fatigue extract added. The control group voice for processing solvent equal amount, positive the control group at glucosamine hydrochloride was filtered of. 24 1000 PPM a culture nor post-incubation time, the n bit parallel data inputted for recovering cell culture, Hyaluronan ELISA kit (R & D Systems) hyaluronic acid using showed to measure a concentration table 4. = 4 can repeated* * Voice the control group of hyaluronic acid concentration reference (100%) in fatigue extract and the cells to a type used in groups into a number by hyaluronic acid concentration As a result, eye fatigue or fibro normal extract increased the generation hyaluronic acid in cells. Benign extract fatigue in addition 100 times more low amounts the control group than the control group positive also revealed a similar a hyaluronic acid concentration. The, fibro normal extract fatigue in hyaluronic acid promoting generation optionally it comprises pigments and of confirming the leg unit located between a main, joint support and arthritis useful in the prevention or treatment of can be used. In the embodiment 5.Intraluminal jointRAT by fatiguein elevated level of hyaluronic acid Inside and outside the male Sprague-Dawley Rat weight 200g (saM tachometer, Korean) 23±1°C temperature of the resin by a roll brush, breeding lighter further adjusted to 55±5% humidity ( daejong top dead center device, Korean) in device 1 then time adaptive weeks, the third to eo experiments. Sample treatment group as saline extract (n=8) fatigue to dilution to 100 or 500 mg per 1 kg weight RAT on which the second photoresist layer is 15 times 11 between the n bit parallel data inputted for oral administration, in the case of the control group (n=8) administered method such as the only solvent. Furthermore, hyaluronic acid concentration a contour of the object for measuring a femur and tibia together as saline 0.5 ml pooled in knee joint in the extraction for scanning the cleaning and, cleaned synovia 100 micro l or more until inspection as blocks, the material filled in the refrigeration storage the -70 ° C. Hyaluronic acid concentration in synovial Hyaluronan ELISA kit (& D Systems R) determined by means of the table showed to 5. * The control group of hyaluronic acid concentration reference (100%) the sample through the polarized light filter into a number by control army hyaluronic acid concentration As a result, normal RAT fatigue extract increased the generation hyaluronic acid in intraluminal joint. The, fatigue extract intraluminal joint In the embodiment 6.Fatigue inHaCaT elevated level of hyaluronic acid by A keratinocyte derived from human HaCaT cells including 10% FBS DMEM the culture medium to which 2x104 cells/ml 24-well plate at 1 ml to frequency divides the metal to. 24 was grown on time after, right serum which do not contain the n bit parallel data inputted is exchanged with 1 ml DMEM medium, 30 PPM extract added to fatigue. Voice the control group equal amount of ethanol processing the n bit parallel data inputted, positive the control group in hyaluronic acid stimulate cytokine production known a glucosamine hydrochloride (Glucosamine hydrochloride, Sigma-aldrich). 48 100 PPM a culture nor post-incubation time was filtered, is recovered and allowed to cell culture Hyaluronan ELISA kit (R & D Systems) hyaluronic acid using showed to measure a concentration table 6. = 4 can repeated* * Voice the control group of hyaluronic acid concentration reference (100%) in fatigue extract and the cells to a type used in groups into a number by hyaluronic acid concentration As a result, fatigue in keratinocyte derived from the human body extract generation increased the hyaluronic acid. The, fatigue extract in keratinocyte derived from the human body optionally it comprises pigments and promoting generation hyaluronic acid checks that the leg unit located between a main, skin elasticity, aging prevention, for inhibiting wrinkles or treatment; and is thus useful for the skin moisturizing and can be. In the embodiment 7. Increase of skin moisture by fatigue Fatigue extract intended to provide a cosmetic containing a human skin increased the moisture amount of the cosmetic composition to apply, 2 e.g. formulations a depending on its composition, cream of the n bit parallel data inputted manufacturing, 22 °C and relative humidity of 50% 30 adult health application in coupling band inner pak under of a constant amount (2 mg/cm2) before applying is applied and, applied 1 2 and coating process has been completed of time it was determined that moisture content of the skin. The control group in the case of comprising the composition in an equal amount and instead extract fatigue and nutrition as well as a roasted method such as cream into its original depositing produced at, determining an operating bit number of an untreated nothing control army has normal skin. Corneometer measurements water retention ability (Courage + Khazaka, GmbH, Germany) brought to the skin surface using it was determined that electrical conductivity of. The result is a list showed to 7. * N=30 As a result, fatigue extract a nutritionally thereby increasing the moisture amount of the skin people cream, cold rolled steel sheet even after vapor time 2 applied showed water retention ability. The, fatigue and increased the moisture amount of the skin extract water retention capacity leg unit located between a main of confirming the very good, skin elasticity, aging prevention, for inhibiting wrinkles or treatment; and is thus useful for the skin moisturizing and can be. In the embodiment 8. By skin elasticity effect through synergistic action of fatigue Fatigue extract of the present invention to provide a cosmetic containing a skin elasticity increase effect to a human for time application to the skin, a 2 e.g. formulations of the n bit parallel data inputted manufacturing depending on its composition, cream, 22 °C and relative humidity 50% of adult health application in coupling band in idyll of 30 before collapsible shift of material and then applying the daytime 4, measures the elasticity of skin elasticity was assessed compared improvement effects of a. Fatigue in the region of the left idyll subject with extract of cosmetic nutrient cream, fatigue in the region of the right instead extract comprising the composition in an equal amount and palatability and nutrition as well as a microorganism beds can eliminate the morning and night cream after add adhesive 12 to the serving daytime 4. Furthermore, dielectric polymeric material and film substrate and skin elasticity (Cutometer, C+K, Germany) increasing the resilient site in the it was determined that a payment terminal. The n bit parallel data inputted used as parameter a degree of improved Ur/Uf, showed to result to the computer of the table 8. * N=30 As a result, fatigue extract a nutritionally cream people has been improving skin elasticity, didn't also within the skin and the no side effects. The, eye fatigue or skin elasticity extract optionally it comprises pigments and of confirming the leg unit located between a main, skin elasticity, aging prevention, and useful in the prevention or treatment of skin wrinkle can be used. Results of this test effect than that of the second body on the basis, the present invention according to various composition formulations. specifically, thereby, the cold air flows. Stage, these formulations relate CDK exemplary composition the present invention, the present invention composition range generates no limit formulations sugar in the surveillance industry will nontrivial twiddle factors and to be person with skill in the art. Formulation example 1. Manufacturing for healthy drink Fatigue extract 0.1 mg 1000 mg citric acid Oligosaccharide 100 g 2 g concentrate plum 1 g taurine The entire applied water 900 ml According to conventional health drink manufacturing method of said then combining a, about 1 should be heated to reach a stirring 85 °C time, to filter out solution made in the sterilized 2L then sterilization in hermetically sealing obtained container rehrigeration custody then was use in the production health drink composition of the present invention. Symbol relatively composition, said beverage components--time but hearts mixing to exemplify a preferred embodiment, layer demand, demand country, using local uses and the like, according to preference in people modified optionally ratio blends. a non-intrusive may embodiment. Formulations 2. e.g. Nutritional cream for manufacturing , Such as composition for the, useful as anti-fatigue of cream nutritional including have been prepared according to method. Fatigue extract 1.0% weight Beta -1,3-glucan 5.0 weight % Lycopene 10.0 weight % As polysorbate 60 1.5 weight % 2.0% weight does peel 60/hardened castor oil [...] 0.5% weight Flow paraffin 10.0 weight % [...] 5.0 weight % 5.0 weight % [...] /capric acnes Glycerin 5.0 weight % Butylene glycol 3.0% weight Propylene glycol 3.0% weight Triethanolamin 0.2 weight % 0.05 weight % preservative Dye 0.05 weight % Perfume 0.05 weight % Purified water to 100 weight % Formulation 3 e.g.: medicament for topical administration (gel ointment number) for manufacturing , Such as composition for the, useful as anti-fatigue including gel salt according to conventional method have been prepared. Fatigue extract 0.5% weight Beta -1,3-glucan 10.0 weight % Polyacrylic acid (Carbopol 940) 1.5 weight % 5.0 weight % isopropanol [...] 25.0% weight Triethanolamin 1.7 weight % Deionized water to 100% weight Formulation 4 e.g.: for the preparation of 2 mg extract fatigue Soy extract 50 mg Glucose 200 mg Starch 600 mg Said asparagus in convenient way for prolonged period, by the addition of 30% ethanol 100 mg 60 °C acetic acid, filtered and dried to formation of the granule after fabrics filling section. Or more from a description, the present invention is in the field of the usual the technician the present invention the technical idea or essentially changing a characteristic the first or the second embodiment form specifically can be database for each consumer 2000. In this regard, embodiment described or more exemplary in all of examples limiting and there has as which was not. must understand. Rather than the description of the present invention said range meaning of claim refers to equivalent and and range modification or all derived from general outline of an altered form is included within the scope of the present invention should interpreted to. A Radix Rehmanniae Preparata extract or fractions thereof effectively promotes generation of hyaluronic acid and expression of a hyaluronic acid synthase, thereby being used in joint protection, arthritis prevention or treatment, skin elasticity improvement, anti-aging, skin wrinkle prevention or treatment, and skin moisturization. COPYRIGHT KIPO 2016 Fatigue ( According to Claim 1 as an effective ingredient composition including joint support; or in the preventive or pharmaceutical compositions for the treatment of. Skin elasticity including as an effective ingredient composition according to Claim 1, aging prevention; for inhibiting wrinkles or skin for treatment or composition. According to Claim 1 composition including skin moisturizing composition as an effective ingredient. According to one of Claim 1 to Claim 4, said cosmetic composition composition, food composition, pharmaceutical composition and medicine external width composition from a material selected from the group consisting of is compositions. According to one of Claim 1 to Claim 4, said composition fractions extracts or their fatigue contrast total weight of the weight 10 to 0.00001% to compositions including water. Sample nothing control Glucosamine 1000 PPM 5 PPM extract fatigue 10 PPM extract fatigue Survival rates (%) 100 97 102 105 Sample nothing control (voice the control group) Glucosamine 1000 PPM 5 PPM extract fatigue 10 PPM extract fatigue Hyaluronic acid the relative concentrations (%) 100 146 136 139 Sample nothing control (voice the control group) Glucosamine 1000 PPM 5 PPM extract fatigue 10 PPM extract fatigue HAS-2 expression amount (%) 100 113 105 138 HAS-3 expression amount (%) 100 121 124 145 Sample nothing control Glucosamine 1000 PPM 10 PPM extract fatigue The relative concentrations HA (%) 100 146 132 The control group Sample treatment group Fatigue 1 is ground - 100 mg/kg 500 mg/kg Hyaluronic acid the relative concentrations (%) 100 112 135 Sample nothing control (voice the control group) Glucosamine 100 PPM 30 PPM extract fatigue Hyaluronic acid the relative concentrations (%) 100 199 221 Unit (corneometer units) Cream nutritional 2 e.g. formulations Cream nutritional the control group nothing control group Also electric skin before applying 55 54 56 Applied 1 process has been completed 104 81 55 Applied 2 process has been completed 94 67 52 Cream nutritional 2 e.g. formulations Cream nutritional the control group Improvement in bounce/body rate (%) 27.89 3.75