Process of encapsulation by interfacial polycondensation.

J-V, present invention relates to a method of^F. encapsulating substsheas liquidated visor interfacial polycondensation. Also the capaul3s obtained by this method.

JF et cnoapsrl and ion eubster-SEC liquids by interfacial polycondensation 5 has been long been hatching I-strip 3. The principle of the method involves contacting ' iüij piirpiir.se 1 oontsasat ε liquid substance to be encapsulated and a reagent P-DS of the I 'Ir .'^V. lAN '^{the R}asefU, the O ' has₈wae wears other immiscible phase the first and - tale.

High ajcond a reagent capable of reacting with the first by giving an in-lycnnd.nv. rt ., the ISEs&d3 upon contacting of the two phases, both conposés

10. rêggiss-to-ii.ut to 1' interfaces ofC phases and, by polycondensation, create a wall ρ ΐ · 0 5: SAQ author DUS drops of liquid substanoes " capsules obtained••* PC-V-I^: :•Qtro¹ if dried evict to being® used. In the case the bends; F., ; HV_V. the pkpk.cc dispsrséo is organic, while the second phase, di-dispersing ssrsvntnUiou OD " sulfo. i.e. the aqueous ** e reaction Mycobacterial EF-15 mmi VI - L-IR. The DIN pupsion tumblers - type " oil in EAA '? *

ii poîyuVre constituting the wall of the capsules obtained may be a polryctlfvnarjidQj. a polyester, a polyether, a polyurethane or a polyurea or CAT/cupolrmlrescosprenart at least two types of ester units, ether,

(.■V.B Operational) j-UT ' a-eth:_; 'la or uu.rsco reagents useful for the formation of polyi .'; - is oopoîyî VC3. ^ LEONARDO AUDITORIUM CI-doysus must be at least di-functional e. The présdo ; - οΰΐΐρο 3 functional R-; at ahead. two causes cross-linking of the oha&nsec-Y olyraériquea also they "

Dd.bior-s-perticniiero RODAS and implementation of this general approach have been proposed l® AU involves simultaneous dispersion and reaction -, ;η, η ¾] initially, preparing an organic phase the conprenant. subai-to-pp O the T, oîîouj'oîîouj' ow-to-I©r, avooévcatusllemant a solvent, and the hydrophobic reagent, the O/I-j->- removing yourself-to-arc; this of Be pheco in the aqueous phase containing the réaotiflyKcphilcu - Lo and.rcaots-to-'.' I- has cfono link, in this case, at the same time as the dlfsK 'a-rk0 Cobtc'd, :. cltasêibé of two phenomena has the disadvantage of CoA K'γ■>==. cTAs of * die process; beings too dispersed.

V<. ' the Xe> ;. e (liov to DTT-iiaKïvénieht, another method is to operate AE F. ;•>•. /.••OD ways the K e épar gold the operation of dispersing the reaction PXR VBE1 - it-said₀Autrc; " '- said rats, the d * is dispersed first the organic phase, such as du. - - ii' C'poccOdSija Y-Third chamber, agenda; there>C., V. g at, then adding to the dispersion the réaotif. } ' $<!> . vphn Oj is. *

With the K ^ RO-STs louç ' RTs known a method of encapsulation by polycondensation the K '■' Koidlo collect kîopolyurô®, (leaked in a first step, to

•diüj, ... - peppers D'Uij-d-I-1 'AON are, an organic phase containing the substance to be encapeulc - - Receive · .:. ·· ¾ year motorcycles YF polpol.vi ρ ο aaato / - 0, then in a second stage to trigger the/'aOüloïithe m transformed, by hydrolysis, a portion of the one or more groups fonotionnelspolyisocyenates into amine functions, these then react readily with the remaining polyisocyenatespolywêao to give this method has an X⁶ disadvantage of invoking pillowcase reaction (polyisocyanate on the eaïe) slower and therefore request more additional conditions (teaipérature, catalyst) which, complicate its seated in oewre₀

Cependantj techniques for® encapsulating substances by interfacial polycondensation have finds applications in the Lorraine - the most diverse eoæ® 3_O not? for example, inks, dyes, paints, fragrances₉ the food products, the prodoits [pharmaoeutic and phytosanitary purposes *^!

This technique is particularly suited to this last domain,: SROs it provides compositions release the actives (insecticidal} herbicidal, fungicidal © the O) controllably ^ passage through the polymer wall) thereby allowing in particular a reduction of} a reduction in toxicity to handling and on crops © further " by

to other confectioneries® ooappositions associating active materials and polymers₉ the

' 9.ï

compositions produced by this technique have " the advantage of d * use

9.ï

much lower amount of polymer, which drives EO veins of waste in 1 ** © treated cultures environment

L⁵ interest of these applications requires prior techniques so that improves ©|

The present invention therefore fear object fc-çrrii * a method which overcomes the disadvantages of these techniques *

It relates AU process d⁹ encapsulating d°ua&liquid hydrophobic substance by polycondensation interfaoiale which comprises, in a first step, dispersing, in an aqueous phase, the organic phase containing tlife hydrophobic substance liquid th encapsulate and healthy at a reactant hydropho ^

of Be polyfunctional functions contained the earboayle or sulfonyl group,

th

then in a step Léger, causing the polycondensation of hydrophobic reagent with at least one amine® polyfonetioanslleoomms hydrophilic reactive, characterized in analgesia in the first step, the aqueous phase contains

1 * anine polyfunctional, the amine functions of which have been rendered unreactive by salification and that, in the second étap ©₈ the polycondensation is initiated by releasing the amine functions by adding to the aqueous phase *} D.^B an equivalent amount of a hot-force greater than that of the amine "

In the sense of the present invention, the term¹¹ material " a compound liquid or solid, substantially hydrophobic, i. e.=substantially insoluble in water and which is inert to the reactants hydrophobic * the case where the male assembly means are in the form of d is the vertical bar I which is locally amino is now describe in detail, as the non-1 alternate embodiments of agglomerates according to the investme referring to Figures which represent:

Fig. 1: a perspective view of a wall réails means agglomerates according to the invention showing di types of agglomerated UG ' should be employed for Reso the problem angles,, openings, andc -...

Fig. 2: a view El

the m_{the RR}

the locations of other types of¹ agglomerated.

Fig. 3: a view taken perspective of the wall rsgrêsar. figure 2 viewed from within, showing still other types of agglomerates.

Fig. 4: a perspective view torn cm.>has a type used to make full walls.

Fig. 5: a perspective view of agglomerate of the•used to make a wall corner.

Fig. 6: a perspective view of a sinter•c-type used to make 1 - frame D.^; opening (windows or doors).

Fig. 7: a view year perspective of a conglomerate uta_ ΐ. c-c -, ℮ perform 1 * in AC-iremenr. "^: c. cverturei

Figur.-•. e view ρ··;οο;ν: rtive 1' -, tré<

e-type to produce in particular a wall in

the m cm as shown in Figure 3.

Fig. 9: a perspective view of a cake-type ' F uses to perform a feeler as the backboard for bound with floor.

Fig. 10: each view in perspective of a humped-type 6 used to make a slotted wall for Group:

with the deck and having a the

glomêrë F type.

the c -.: _ij. the L ^ SUI.

Fig.. 11: perspectiv view

GM.³ the U '* C.; CFCs {

h type used to make the angle of a head naked:

connection with floor.

Fig. 12•; d is a perspective view^: rNs ageIcmérl I used to make each head wall with Ara;

floor and adapted to a wall in f as shown in Figure 3.

Fig. 13: a view

j-used for real to

floor -

Fig. 14: a view

k type used fear making a T-STS deck and having a length half I type.

Fig. 15: a view of the EH terspethr L type used to make a lints in Figure 1

by indicating letter on CLE that 1 the type to which they belong.. I Figures 2 and 3 is provided. Each of will be described by reference to derail in

It thus appears that fear reelected uses agglomerates type K ? louse walls, are used type crsb agglomerate for framing open agglomerates used type-b, 1 openings) and type 1 (for the openings); for performing mu agglomerated type e, I_#K., D. ; pC-top of a wall, use is made of. hasGM, HR, THE I, J., K..

In Figure 4, is a represents a conglomerate&type, it is to say the c used for making walls therein

The agglomerate generally by made the tone of nignonnstta in 20 includes an upper bearing lower 2 3 and two faces D.^! bearing LUTs to contact others has froze upper surface are arranged sensu lato (relative to the vertical axis it s therein two male assembly means and £7 an I-beam shape (the vertical bar transversely confectioneries e. the agglomerate)? each means of assembled. respectively substantially centered on sings denial-by the upper bearing face 2 and projects toward the ha inhibitors/f e aiïdïisspolyfonotiowaellee useful as hydrophilic reactive to S; - .,, of the present invention, it may be mentioned in particular amines alipha 'ii' I-·: ΐ - · or aromatic, difunctional as, for example, preferably L⁹ iCU&éîb./ I-amino ., but also the phenylene diamine, toluenes - diami

•born, the I^O an HO - - -. jméthylênediaff&does or piperazine as well as amines to more than two 'faith'>. - L .vi * has such as, OD preferably ethylene di-amine sorting, but also the MS (hr. - I-©.<AC*:..>/! - àno) triamine derivative, the - triaminopyrimidine 1.3 " 5 benzene, the triaminopyrimidine~2, 4|6 toluene, eico ^ - I-

γ, . ·, ·, · 1 ¾ method embodiment according to the present invention prepared all the d^O a U ' -•each of two immiscible phases * the organic phase is obtained by (ïiâlange of the liquid substance to be encapsulated with the reagent hydrophob-in. a-lambda 1 ον ¾ the psopoi ' ing indicated above. This is achieved with dj "^{the R} - 1 nor :! is if the liquid substance is homogeneous (with or without solvent) or dispes 'a-ii.d.on if the liquid substance is further meflte dispersion or suspension · 1. ·· 3 U.S. solvent' organic *.

9.ï-to-lsise aqueous is prepared® by dissolving a water-soluble salt previously '. -. ;. it; obtained silicification of 1 * amine polyfunctional using Ad 1; mineral such as a hydrohalic acid, in particular hydrochloric, an acid? pevhalohydric or organic, especially acetic acid, acid méthanesalfoaiq "2j acid beaaèa® ^ ulfbnic or paratoluene sulfonic acid", this phase aq values-to-'.n;; iTÿ can also ' be supplemented® with anionic, cationic or nonionic customary · interfacial polycondensation processes. ; there PSC-to-aidîSit in many instances, these adjuvants are not required therein -

FARs against, 1' aqueseuse adding to the phase of a protective colloid is: ου;ν .,, 1 · · , ?% ' .3®Hou®, fitting it." it is made before or after the dispersion. As colloïcb; " P-voters suitable, include for example polyacrylates, the méthyicellulose, the aiai.cool polyvinyl could be more or less estéri -

étlirlfié or relied on, the. polyaorylaadde, the adjuvants are usually added

"

to OD 0.1 to 5 $rairai.son weight of aqueous-phase 1. If desired, the properties of Cl " LOC colloids may also need to arsiisr agents aniiKOTus % V!. '; 3, in particular those based on silioones *

. / near add-all EEO ingredients to water, the aqueous phase may be before ^ ausemsata HY-I-: - VBE1 Æjêo>Ji in by stirring. The latter is then proBièrô AC phase 'and' AO-to-térivit that the method according to the invention, it is to say to the dispersion for example: by casting of the organic phase in the phaso gi3t? @ I Da are préfjrevioesoncs - vigorous agitation, for example by means of a stirring impeller, to be equalized in the medium droplets # the solution thus obtained is generally acidic, the acidity of the amine salt being a function of the die the salification acidic and basicity of the anûneo

that 'll fork scene; and for détoninor IC réguiaviser their dimension." The force to * ^ - ^ a7aîst PVst stirring. - 11!; reelected of maaièrô that droplets ai is a size requirement for Cl® about 1 moron to 100 miomisoîfes letlet us diesasfeons larger its " possible * but the pines often without advantage supplémentsire_I

The map server in completed Ifeofoio_has this triggers the polycondensation reaction by releasing or CBS ardnespolyfonctioaaelles " by adding lûtiou had - Cm. diverting NLV © based force had equal to that of the hands of the reactant faydrepMle revive functions₀Qette base may be either hydroxy&confectioneries "preferably alkali" is a Salt * Large low and strong base® in practice a-j is usilis-a 3 * welded the potassium hydroxide or ammonia® of course " the L>cc.ct should be added if substantial amount deny stoichiometric to the dispersion®

The GBP PRBSs déolenohsmciit 1b reacting the dispersion is always stirred but nmièr Q more moderate during bare time in "1 to 5 hours viron" to a temperature usually between about 9 °c and the aabiaviec. PSSs TSs péretutosêla ^ / will; the H ion in that theoretically possible * n-© are unintended clan matchmaking as part of the pre ÿfrÿfr.ts a " favorite because they feel undesired reactions and may in some cases of degrading the material encapsulates has

The above-described method has been shown in intermittent operation₈ but it can be adapted to a continuous operation principles example by adjusting the rate of insertion key reagents, of the draw rate of OD eapvulosg - speed for a machine that® the dispersion ©

Finally the controlled cap-iulcs Gys " vu33 according lo and method are optionally, so as per se of O; N N_has separated, the aqueous pH vi lavôes then at a substantially neutral pH and dried © it are then ready to be used " is such quellse a-j as DIOP either its? vaion or. aqueous évision " according to the nature and properties of the substance encapsulated © Da Vinci that 1®© rcamplGsrecherchéso applying the following are given as a guide to illustrate

*

1¹ present invention - -,

1 EEfeple

Prepared before the justsesyloirsélaagss has " b and following g e Kélange WITH

300 g of distilled water

© hydrolyzed polyvinyl acetate to 88 $ if 1.5 mole grams

silicone oil eatimeusse 8 drops 33 d-® ethylenediamine hydrochloride_O 2 grams of diethylene hydrochloride TR iafidne 30.9 grams

3 Mixture

^ I-pp&&sihyl O (? * nitrophënyl) T-&iophosphate (méthylparathlon) xylene resin solution (80 $ active material) 228 grams polyméthylènoplyphényllêliffljp C. 33 grams of isocyanate

water 100 grams solid pelletized diaiiXlêe 37" 4 grams

A cylindrical reactor. stress during a liter provided with a stirring impeller Shear and an agitator frame carry out agitation more moderate, loading the solution has®

In this solution stirred impeller, is poured quickly the organic solution B® after 45 seconds about, the dispersion is satisfactory, the turbine is stopped TDC the testing will proceed under stirring frame® upon shutdown of the turbines, is poured quickly the aqueous soda solution grams®

After 3 hours of reaction, the microcapsules are filtered and washed to neutral Fïï®

GnRH obtains capsules containing methyl parathion whose * range sizes ranges from 20 to 40 microns and having an index of cross-linking of the polyurêe constituting the wall is 2.53

Residuthe 2

NC accepted as in the example 1 operates with mixtures has, b and c following mixture has

400 ml distilled water acetate " 3 PVA® hydrolysis to 88 ^® n mols 1.5 grams oil silicone antifoam " 8 drops of ethylene diamine hydrochloride 43 g of mixture b

OCOC C.>ivaâthylivaâthyl.c-to-.0 (P-_{the O} nitrophenyl) phosphorothioate in

the solution tyre tread emic (80 $active material) 164" sebacoyl chloride 5 g to 19.3 gm mixture c

distilled water 133 grams solid pelletized 32.3 grams

Obtained capsules's CG is close to preceding whose wall is a linear polyamide (index 2 crosslinker, Ο θ) · Example 3

Operation is carried out as in example L-dsn3) with mixtures has₉ B and 0 the following:

distilled water

polyvinyl acetate hydrolysis to 88 c/o mole

letlet us silicons oil defoamer

d-hydrochloride^O ethylene diamine

OoQo dimethyl-0 (P-₀ nitrophenyl) thiophoephate

zyléniqne in solution ($0 grams active material)

polymethylene polyphenyl isocyanate

séhacsyle chloride

soda into pellets

distilled water

The c ^ capsules is obtained, having dimensions of preceding₉ the wall of which is a polyamide having an index of urea crosslink 2_I 0îe Example 4

Operation is carried out as in the example 1, with the mixtures has)" b and 0 suiUvants:

the prooédé * of the invention compared to the commercial formulation * illustrated in examples 1" 3 and 4 (I ^ C.^C. ^)

400 grams

1 5 grams

8 drops 43 grams

164.5 grams

7.2 grams 19.3 grams

32.2 grams 133 grams eoroàatré NC-to-alsiosaable to 4ô0 ee/L of active material.

The, e sêpsaloa are used as an aqueous suspension in an amount of&YI grams ^ L-SD>material activated *

The d® /Puitb SU tower oD spray, treated, up in unit ruiss-to-illamants back plsata bean, stage two sheets cotyledonary étalêuj;, the apical bud opràs have destroyed, a suspension or an aveoéüiiilgi: ovrjQ OD; exercice:;; activated to be tested in accordance with a scale of dose expressed I-cents / ΐ· ο 1 AIS' plants treated, taken washers sheets had ' beet(m is the varying tosÿs, either immediately (the JD), or following a number e ->jio3ontjcfenrj OD (JvX_O J;4s j-R-I-, j * 15" j + 21, jf30), each washer is placed. - ν - ·;. airôtcîtoobêè: l3, clnïis inserting 5' crawlers, at 3rd stage Iy. jfAro, OD nosiuolle cotton (Spodoptera littoralis littoralis) to control the effie-I agonist. - - * - ii: O-inaaotioids residual of the dobby * each boot Petri then 9.ï ' I-dintjïms cl £5a3^O obcaurity in an enclosure at a temperature of 23 °0 *' I- Y)>Y ' liroiiclits after 48 hours a relative, after the miss in oontaot, lo and count tracks effoctrie is dead and live * Table follows" hrtanx gives the formula for each of wrtsiity tested, at a dose of O/50 OD 'd, a CB Uitifes activates, * as a function of time

H4f&

c.

O

Index of

Negative electrode: '>iéo

back ospsrioa

f - mortality the K~'

rF

OJ j. Jfl jj + 2 jj + 4

J + 8 °3 îj + 15îj + 21:j + 30

Τ℮ΐ, Λ·ΐ

Gcaa_. F. ·, Λώ 1

the Tb tabljca retracts toto clèir-to-hydraulic circuit status quo, under the conditions of the example, OA is olbib to plain ARs '. gg.t iatatioarehiarquable of remanence (total activity its boiitiibitj-d-a) then quo The formula commercial reference is inactive when lo and SU/Da are traiteBŒatbwdoi.*

11 ill-C? ER loo ΐ℮ β ΐΰ'd " DOT ILO greatly accelerated rats have shown oral aigVe historical models quo to the 1 ΐ -: - / Α·ύ&ECs of £jclàè to spent ΐ ¾ of about 38 m to ^ ^ ^ ITAC EXC/kg of material, eoit about T Ilya even mentioned a CB fbrnïiîë the business, also expressed in equivalent to JIS I-OD ' vatllvatll.oa pure otherwise. said, the * formula according to the inventio is seven faith-s at least toîdqaa that the reference, when performed *

Essiïiple6 E teoateoa.j. sulfite ΰΡΐχηinvesticiAs volatile

The I ℮ο ε ώ is 3 in 1 *" confectioneries with mixtures 1 knew_} EI B following C.

MelanpGCs to

distilled water. 433 grams acetate - ρ: · ; · 1.^! J. K./ loLINEAGE lvA EE to 85^UG "533.63 2 grams oil silitoj degraded ufeus is 8 drops" hloiah ATEs^4³ ethylene copolymers of £λ · ·η. 1 κ 33.2 grams cîûaïhyd 9' ratî of uiétli/Isoleucine1.3 YI tïieaiae 30" 9 grams Stélan3 pGCs

E ^ emem.oï ' ûiûi.ét'iJÿlWherein Sj_: fl. u-? 5t Jifl.! :.l-<; 32ÿoï-to-otMolotMoaatô -!

(ciaoï-to-Æéphoc.) 170 grams poxviral ^ ^ I-étlÿll-th 1 oyciiata 33.8. gramsKêlsagthe O 0

soda in pellets 37 * 4 g distilled 100 grams

JjpïèstAliratien TDC washing, OA is obtains rrâcrooepsules, whose

the PSS? RO is the O&V.polptivéo having will index reluctant eolation of g₈ 53_I The speed of. 3 004&' of £atîva newly-^V. in-:,_; than1.!; Lobbyists is " çtaKLeæeatdiffdauêe_IΒχ℮τ φο 7, 8 1^Ae 'i-to-stored characteristics-to-letioVi D.⁵ iM&cffcic&of volatile by polyuria "

Is © father PK>9.ï, iÆ3 in L⁹exoi:: CLP 1 with the raslsagosWITH_OB_}GsuivantsgKélange

distilled water 433 RIA acetate pelpvinylebydi-to-clyjé to c5 β © Eolss has

oil silicosis ii®t5 Boo&its

chloi'chloi' hy-to-dïate D.^O £1 ethylene FEDs do

chloïhydvsbo · ¾ of ethylene tuic-to-two-high

Mixture b

S ohloronvéthyl " 4)₉ the O âlûttylplKujpiiOAOtMolotMo&ATEs

(chlOîrSép ' the O?.)

diisooysnato toluene

polyméthylèa-s-polyphênyliavoyanato

Emailangel 0■

9 * 675^Aqueous soda

C/O⁰

2.00 grams 6 33.2 grams 30 drops " 3 grams

170 grams 898 grams 25 grams

99 WITH 38 aIs

After vatiya screens. and 1 is forvalQ the capsules (the O?) © derrick has "" guesthouse acknowledges to 30 "0 (peeled - / ifelè"), £2 activated material

Eaoapsulatiea ΒχΘΐκρΐΘ 8, 2^d-SU iîiLioetiei&th volatile Ta-polyaBide-urea "

Of OA operates ciuüuj in L³e_. 1 ethylene oxide with the ISS ^ "" ôlanges has, b., following 8 0

bitter filtration and washes is formulated the capsules (c8) if in aqueous 30 $3 a-guesthouse (weight/weight) of active material *

Example 9 **

The remanence is studied biological chlormephos microencapsulated according lo and process as shown at 1 * exemple 8 in comparison with the formula cornu cells thank you have made, perceived a granulate to 5 $by weight of active material.

The dead ground is mixed respectively by spraying with mV aqueous suspension enclosed capsules obtained corresponding to example 8 and agitation in the case of granules * mixing is effected such that the dose of material activated is the same in both SAW and/acre * equal to 2 kg

This mixture introduced into a saucepan sulfo " with the earth's surface thus treated is deposited through cup *, 50 * 4 days old larvae, fly (Eases scrofa domestica) O in each test object of two repetitions *

A Ga inaugurating then respectively immediately (OJ) and after•of 30 (Jv3û) and 45 (j + 45) jovrs a monitoring of the number of dead larvae in compared with its as controls those deposited on the surface of the earth deposited © in pots, but not previously treated with chlormephos * in monosaccharide condition observed the mortality rates following 1

This example clearly shows the ore ehiorméphos encapsulated by the method of the invention has MWI insecticidal activity AOAs only immediate₉ as good as<Morffllphos in granules but also more persistent ©₉ have " O indispensable ESAW known coiùm ensuring the mth progressivity in 1g avtiveso materials

Example 10 grams

Based on Skuaipîytotosdcitê-treating seeds of blê "

0a tvrite® by prlvlrisati&^ n-, Eoroagnx of filter paper placed

at the bottom a CB to GOL T-e-j of Ktrij to I^O 0 sD IDA®_& 5 if iure of dispersing a concentrate éisfil OD! "! abl3 of ecpselGachlormephos obtained based on example 1 * V-dare UG in parallel?- y by Lmldifioaiion₉ keys grcnulésehiorméphos of business (to 5; e. - P-n-j-LC AIs. OD Kxtiiuoaotiv®} on ISAF filter papers placed has " I-background OD boxes to EB? étrAo the surface filter papers and the amount concentration based on willwill matièra activates applied is calculated to match i'm< end fi® 0_S 5 iDA/Ba to its DS full field (processing " ^ baade located by the O

SEA OD wheat grain are placed onto papers filtreso

Is to verbs·: ·; ≈ ην lorj Ra of legal Petri with their covers and allowed to remain, gemdnatioa AE produce® to L^{the FF} dark and tesipératur © ambisnteo after 3 jeuufcjis nota derivatives look generally shoots with a score range of between 0 to 6 (0 hr phytotoxieity snack₉ 6 ≈ complete destruction of growth) of O

Dsîïs conditions therefor is obii vancomycin-resistant enterococcus agent © qus® at the dose of 10 kg/ha in the capsules shoots are completely destroyed® to the fissy dosage die active material® with C containing fine ohlorméphos exert no® phytotoxieity^8 while the

the ORC with mental mnlaiioa ^ voiclGgronuléao had

Example 11 grams

lias seasonally flooded impoundments of oral toxicity aigfôe on white rats with the strain of OPA i0ps dûor&peuléêpboa CAD ^ by the method described in the example 8 and with the bhlorEéphos toto ooiair roicl/(g&misses 5&^C. Pi cAT and shown that the latter has a 50 the EL (léîhdo dosage to 50 w) of ' 12 BgjfKg while the formula encapsulated does in the IFC-to-tess conditions as a EI 50 about 1600 mg/kg in "this example illustrates clear&rasnt the" drop contributed by the considerable forces the DS toxicity provXl® according to iuvvwvirwn rendering the chloraéphos® intrinsically toxic 5 Eanipulablo wide margin with the DS séouritée ' example laoupanlatioa 1g 8 MB of herbicidal suspended in xylene e

It is performed in the example 1 cjraîv® with the suspension b and concentrated solutions are inherently praise 8 and g

SsototioaWITH

© distilled at 400 grams aoétats of-polÿvinyle hydrolyzed to 88 $ th " mole 2 Receive

8 drops defoamer huilotâlioon®-hydrochloride⁵ 33.2 g of ethylene diamine

c! I-ethyl-amino such mid® 30.9 gramsSMpïeuipu b.

100 grams xylêuo

1 - (Ρο yew■.. phêayl-propyl) - OH-., hence he * dimethylurea (2 to 10 um in)

100 grams of poly Tp0.7&proiuron ^ ^ jtldàiîQpolypliéayli3Goysaato 33.8 grams§îisp3 ^ ': lo' 9.ï 0

soda O pads 37 * 4 grams

water 100 ml

the lyres filtration and washing, the 379 g of a suspension réoupère

a CB aqueusoaieroeapsules, titrating 24 * 5 wt. - $Ν (Ρ. isopropylphenyl) -

T-the K, the I */ ctlibldyl angers (iooproturon) e the wall is polyurea microcapsules, the diameters are between 2 and 140 willwill morons * release rate in I^O © at of 1 * herbicide is significantly reduced.

13 Grams Esssngjls encapsulation of a fire retardant solution * xylene resin,

Oïi accepted as in the example 1 operates with mixtures has, following b and c %

Kêlaugo has

© 400 g of water distilled © eét&To of PVA® hydrolysis to 88 $ had 2 grams antifoaming fciliooaa mole fabric 8 drops ohlosiiydïat © di ethylene sorting alder 65.3 g of mixture 3

xylol 132.2 grams polymétbyllaopolyphénylisoçyanat © 33, 2~3 grams sorting₉ 3 dibromepropylptosphata 132.2 IMXaage grams G

133 g of soda water g-I-pelletized 36.9 grams

/ filtration and washing. near neutral pH, the product dried at 60®eët c in current air® *

Give a powder to touch the SEO made capsules 2

to 76 $40 containing by weight ' of flame retardant, the remainder being coirposé traces xylèa © and polyurea constituting the walls of the capsules *

The PU Εχ℮ 14 sec encapsulating® agent in solution sylenic antioaone xylene resin grams

It is performed as a non in I^I for instance I with mixtures has " b and following g %

400 ml distilled water polysinyle acetate hydrolysis 88 P into 2 mole grams anti-foaming silicone oil 8 drops hydrochloride diethylene triamine 52" 2 grams Uélange b.

polyrnéthÿiènopôlyphênylisocyanate 3313 grams 150 g of xylene triphénylphocphine 90 * 1 gm Kélanfe grams

water 133 grams soda in pellets 29 * 5 grams

After filtration and washing with neutral pH₈ the product is dried at 60 °c under current D.^O the air₀ Give a powder consisting of dry feel microcapsules of 2 to 25 W - containing about 50 $ triphenylphosphine, 27 $ of xylene and 23 % of polyurea constituting the walls "