ЛЕЧЕБНАЯ ЖЕВАТЕЛЬНАЯ РЕЗИНКА

FIELD: food industry. SUBSTANCE: invention relates to food industry. The chewing gum composition contains a chewing gum base, a biologically active ingredient, a polymer material and one or more sweeteners or taste-and-flavour additives. The polymer material is amphiphilic and has an unbranched or branched carbon-carbon main chain. Additionally, one or more side chains of the specified structural formula is/are connected to the main chain. The chewing gum composition production method envisages preparation of a chewing gum base by way of mixing an elastomeric material with plastifiers and/or softeners, and/or fillers, and/or emulsifiers, and/or waxes. Then the said polymer material is added to the chewing gum base. Then the biologically active ingredient combined with one or more sweeteners or taste-and-flavour additives are introduced into the base. EFFECT: invention allows to manufacture a chewing gum with an increased rate of biologically active ingredient release from the chewing gum composition. 24 cl, 8 dwg, 27 tbl, 14 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 476 076 (13) C2 (51) МПК A23G 4/08 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2009134941/13, 26.02.2008 (24) Дата начала отсчета срока действия патента: 26.02.2008 (73) Патентообладатель(и): РЕВОЛИМЕР ЛИМИТЕД (GB) 2 4 7 6 0 7 6 (43) Дата публикации заявки: 10.04.2011 Бюл. № 10 (45) Опубликовано: 27.02.2013 Бюл. № 6 (56) Список документов, цитированных в отчете о поиске: US 2006286143 A1, 21.12.2006. WO 2006016179 A, 16.02.2006. WO 00/35298 A, 22.06.2000. RU 2291688 C2, 20.01.2007. 2 4 7 6 0 7 6 R U (86) Заявка PCT: EP 2008/052326 (26.02.2008) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 28.09.2009 (87) Публикация заявки РСТ: WO 2008/104547 (04.09.2008) Адрес для переписки: 191186, Санкт-Петербург, а/я 230, "АРСПАТЕНТ", пат. пов. В.В.Дощечкиной (54) ЛЕЧЕБНАЯ ЖЕВАТЕЛЬНАЯ РЕЗИНКА (57) Реферат: Изобретение ...

ЖЕВАТЕЛЬНАЯ РЕЗИНКА И ГУММИОСНОВА

FIELD: food industry. SUBSTANCE: gum base contains a food triblock copolymer with a molecular weight equal to 6000-400000 Da. The said triblock copolymer has a soft medium block and rigid end blocks. The soft medium block accounts for at least 30 % of the total weight of the three block copolymer. Glass transition temperature T g of each rigid end block is lower than 70°C. Additionally, chewing gum is proposed. EFFECT: invention allows to produce chewing gum with decreased adhesion to surrounding surfaces and acceptable chewing properties. 35 cl, 13 dwg, 9 tbl, 45 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A23G 4/08 (13) 2 532 049 C2 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012112618/13, 10.09.2010 (24) Дата начала отсчета срока действия патента: 10.09.2010 Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 20.10.2013 Бюл. № 29 (45) Опубликовано: 27.10.2014 Бюл. № 30 2000019837 A1, 13.04.2000. US 7247326 B2, 24.07.2007. RU 2325074 C2, 27.05.2008. RU 2300201 C2, 10.06.2007 (73) Патентообладатель(и): ВМ. РИГЛИ ДЖ. КОМПАНИ (US), РИДЖЕНТС ОВ ЮНИВЕСИТИ ОВ МИННЕСОТА (US) (85) Дата начала рассмотрения заявки PCT на национальной фазе: 10.04.2012 2 5 3 2 0 4 9 (56) Список документов, цитированных в отчете о поиске: WO 2004028268 A1, 08.04.2004. WO R U 10.09.2009 US 61/241,080 (72) Автор(ы): МОРГРЕТ Лесли Ди (US), ХААС Майкл Эс. (US), СЯ Сяоху (US), ХИЛЛМАЙЕР Марк (US), МАРТЕЛЛО Марк Ти (US), МАКОСКО Кристофер (US), МАРТИНЕТТИ Лука (US), БЕЙТС Франк (US), ЛИ Санво (US), БАНЧЕК Майкл Ти (US), ГРИНБЕРГ Майкл Джей (US) 2 5 3 2 0 4 9 R U US 2010/048508 (10.09.2010) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2011/032026 (17.03.2011) Адрес для переписки: 119019, Москва, Гоголевский бульвар, 11, этаж 3, Московское представительство фирмы "Гоулингз Интернэшнл Инк.", В.А. Клюкину (54) ЖЕВАТЕЛЬНАЯ РЕЗИНКА И ГУММИОСНОВА (57) Реферат: Изобретение относится к пищевой Tg ...

КОНДИТЕРСКИЙ ПРОДУКТ, СОДЕРЖАЩИЙ АКТИВНЫЕ И/ИЛИ РЕАКЦИОННЫЕ КОМПОНЕНТЫ, И СПОСОБЫ ЕГО ПОЛУЧЕНИЯ

... 1. Кондитерский продукт, содержащий экструдированную корпусную часть, причем корпусная часть имеет множество расположенных в ней капилляров, и содержит первое создающее ощущение вещество и второе создающее ощущение вещество, которое отличается от указанного первого создающего ощущение вещества, размещенные в отдельных и ограниченных областях указанного продукта и предназначенные для создания профилей последовательного высвобождения.2. Кондитерский продукт по п.1, содержащий от 5 до 50 указанных капилляров.3. Кондитерский продукт по п.2, содержащий от 10 до 40 указанных капилляров.4. Кондитерский продукт по п.3, содержащий от 20 до 30 указанных капилляров.5. Кондитерский продукт по любому из пп.1-4, содержащий первую группу указанных капилляров и вторую группу указанных капилляров, причем указанная первая группа капилляров, по меньшей мере частично, заполнена первым материалом начинки, содержащим указанное первое создающее ощущение вещество, и указанная вторая группа капилляров, по меньшей ...

КОМПОЗИЦИИ С ЦВЕТОВОЙ ИНДИКАЦИЕЙ

МНОГОЗОНАЛЬНОЕ КОНДИТЕРСКОЕ ИЗДЕЛИЕ

... 1. Композиция кондитерского изделия, включающая: ! a. первую зону, содержащую материал в форме частиц, причем указанный материал в форме частиц имеет отрицательное тепло растворения, а плотность при встряхивании указанного материала в форме частиц составляет от 0,4 г/мл до около 0,8 г/мл; ! b. вторую зону, содержащую растворимую жевательную матрицу, причем указанная вторая зона по меньшей мере частично окружает указанную первую зону; и !c. третью зону, по меньшей мере частично окружающую указанную вторую зону, причем указанная третья зона содержит покрытие. ! 2. Композиция по п.1, в которой указанный материал в форме частиц выбран из группы, состоящей из маннита, сорбита, декстрозы, фруктозы, мальтозы, мальтита, лактита, изомальта, эритрита, сахарозы, мальтозы и их комбинации. ! 3. Композиция по п.1, в которой указанный материал в форме частиц является кристаллическим. ! 4. Композиция по п.1, в которой указанная вторая зона включает одну или более полость, каждая из которых имеет объем, ...

СИНЕРГЕТИЧЕСКИЕ АНТИБАКТЕРИАЛЬНЫЕ ЭФФЕКТЫ ЭКСТРАКТА КОРЫ МАГНОЛИИ И СЛОЖНОГО ЭТИЛОВОГО ЭФИРА Nα-ЛАУРОИЛ-АРГИНИНА НА БИОПЛЕНКУ ЗУБНОГО НАЛЕТА

МАТЕРИАЛ В ВИДЕ ЧАСТИЦ ДЛЯ КОНТРОЛИРУЕМОГО ВЫСВОБОЖДЕНИЯ АКТИВНЫХ ИНГРЕДИЕНТОВ

... 1. Материал в виде частиц для контролируемого высвобождения активных ингредиентов, при этом материал в виде частиц содержит комбинацию одного или более активных ингредиентов, за исключением никотина, и неорганический минеральный наполнитель, причем этот активный ингредиент обратимо абсорбирован в и/или на этом неорганическом минеральном наполнителе, при этом удельная площадь поверхности БЭТ этого неорганического минерального наполнителя составляет более 15 м/г при измерении удельной площади поверхности БЭТ по стандарту ISO 9277.2. Материал по п.1, в котором этим активным ингредиентом является ароматизатор.3. Материал по п.1 или 2, в котором этот неорганический минеральный наполнитель содержит карбонат.4. Материал по п.1 или 2, в котором средний диаметр этого неорганического минерального наполнителя находится в диапазоне между 50 и 0,1 мкм.5. Материал по п.1 или 2, в котором масса высушенного неорганического минерального наполнителя увеличивается по меньшей мере на 1 вес.% при относительной ...

ПИЩЕВЫЕ СОСТАВЫ С МЕДЛЕННЫМ ВЫДЕЛЕНИЕМ

... 1. Пищевой состав для медленного выделения активного ингредиента, содержащий следующие элементы:a) водорастворимую сердцевину, содержащую по меньшей мере один активный ингредиент;b) внешнее покрытие, полностью покрывающее сердцевину a), содержащее менее 3% воды, и получаемое путем выпаривания водной дисперсии, которая содержит:- по меньшей мере один виниловый полимер- по меньшей мере один защитный коллоид, выбранный из целлюлозы, модифицированной целлюлозы, поливинилового спирта, полиуретанов, крахмалов, модифицированных крахмалов, мальтодекстринов, полисахаридов, пектинов, акриловых полимеров и их смесей,причем:- эмульсия и внешнее покрытие свободны от эмульгаторов;- эмульсия и внешнее покрытие свободны от поли-винил-пирролидона, при условии, что виниловый полимер не представляет собой поливиниловый спирт, когда последний используют в качестве защитного коллоида.2. Состав, в котором промежуточное покрытие, имеющее более низкую водорастворимость, чем сердцевина a), введено между сердцевиной ...

КОНДИТЕРСКИЙ ПРОДУКТ, СОДЕРЖАЩИЙ АКТИВНЫЕ И/ИЛИ РЕАКЦИОННЫЕ КОМПОНЕНТЫ, И СПОСОБЫ ЕГО ПОЛУЧЕНИЯ

... 1. Кондитерский продукт, содержащий экструдированную корпусную часть, причем корпусная часть имеет множество расположенных в ней капилляров, причем один или более из указанных капилляров, по меньшей мере, частично заполнены материалом начинки, содержащим активный и/или реакционный компонент, который является летучим при температурах 35°C и выше, и при этом указанная экструдированная корпусная часть не содержит указанного летучего активного и/или реакционного компонента, причем указанный летучий активный и/или реакционный компонент выбран из вкусо-ароматических добавок, активных компонентов для ухода за полостью рта; подсластителей; физиологических охлаждающих агентов; согревающих агентов; покалывающих агентов; окрашивающих добавок; шипучих добавок, фармацевтических агентов, нутрицевтиков, растительных экстрактов, средств для отбеливания зубов и их комбинаций.2. Способ изготовления кондитерского продукта, содержащего экструдированную корпусную часть, имеющую множество расположенных в ней ...

ИММУНОМОДУЛИРУЮЩЕЕ СРЕДСТВО, ПРОТИВОРАКОВОЕ СРЕДСТВО И ЗДОРОВАЯ ПИЩА, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ МОНОАЦЕТИЛДИАЦИЛГЛИЦЕРИНА

... 1. Иммуномолулирующее средство, содержащее в качестве эффективного ингредиента производные моноацетилдиацилглицерина, представленные формулой 1, приведенной ниже: где R1/R2 является 9-октадеценоил(олеоил)/(гексадеканоил(пальмитоил), гексадеканоил(пальмитоил)/(9-октадеценоил(олеоил), гексадеканоил(пальмитоил)/9,12-октадекадиеноил(линолеоил), гексадеканоил(пальмитоил)/9,12,15-октадекатриеноил(линоленоил) или гексадеканоил(пальмитоил)/5,8,11,14-эйкозатетраеноил(арахидоноил). 2. Иммуномолулирующее средство по п.1, в котором производные моноацетилдиацилглицерина, представленные формулой 1, являются моноацетилдиацилглицерином, представленным формулой 2, приведенной ниже: 3. Иммуномодулирующее средство по п.1, в котором производные моноацетилдиацилглицерина стимулируют в Т-клетках секрецию цитокинов, выбранных из группы, включающей IL-2, IL-4 и IL-5. 4. Иммуномодулирующее средство по п.1, в котором производные моноацетилдиацилглицерина подавляют повреждение клеток, возникающее в результате аутоиммунной ...

A CHEWING GUM

Soft coated powder centre-filled gum

Cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum comprising water-soluble chewing gum ingredients mixed into water-insoluble gum base, wherein the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8- 50% by weight of the gum base, and wherein the one or more elastomer plasticizers comprise one or more polyvinyl acetate elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum comprises one or more cannabinoids.

BREATH FRESHENING AND ORAL CLEANSING PRODUCT

Powdered chewing gum compositions, the use thereof and a method of preparing such compositions

CHEWING GUM COMPOSITIONS

A chewing gum base which is cud-forming and chewable at mouth temperature contains a food acceptable tri-block copolymer having the form A-B-A or A-B-C and comprising a soft mid-block which constitutes at least 30 wt.% of the total polymer and hard end-blocks each having a glass transition temperature below 70°C. The tri-block copolymer is optionally plasticized with a compatible di-block copolymer to function as an elastomer system in the gum base.

COMPRESSED CHEWING GUM TABLET

CONFECTIONERY COMPOSITION INCLUDING AN ELASTOMERIC COMPONENT AND A COOKED SACCHARIDE COMPONENT

The present invention relates to confectionery compositions including cooked saccharide including polyols such as maltitol, erythritol, and isomalt, and a chewing gum base.

SYNERGISTIC ANTIBACTERIAL EFFECTS OF MAGNOLIA BARK EXTRACT AND L-ARGININE, N-LAUROYL ETHYL ESTER ON PLAQUE BIOFILM

The present disclosure relates generally to oral compositions and methods for inhibiting the formation of plaque biofilm by salivary bacteria, and more particularly, to oral compositions comprising a combination of magnolia bark extract (MBE) and L-arginine, Na-lauroyl ethyl ester (LAE). The oral compositions are useful for improving oral health, including inhibiting the formation of plaque biofilm by salivary bacteria and reducing plaque adherence to teeth.

CANNABINOID CHEWING GUM WITH SUGAR ALCOHOLS

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum comprising water-soluble chewing gum ingredients and water-insoluble gum base, wherein the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the water-soluble chewing gum ingredients comprise one or more sugar alcohols in an amount of 35-80% by weight of the chewing gum, and wherein the chewing gum comprises one or more cannabinoids.

POWDERED CHEWING GUM COMPOSITIONS, THE USE THEREOF AND A METHOD OF PREPARING SUCH COMPOSITIONS

The present invention relates to a powdered chewing gum composition, which contains over 50% w/w chewing gum base and wherein at least 95% w/w of the particles of the composition have a particle size of less than 1200 micron in diameter. The present invention also relates to the use of said powdered chewing gum composition. The present invention also relates to a chewing gum comprising a) a core compartment, b) one or more layers comprising the composition of the present invention. The present invention further relates to a method for production of said chewing gum comprising the steps of: (a) providing a core composition; and (b) coating of the core composition with a powdered chewing gum composition by use of a panning process; and optionally (c) coating the outer intermediate layer with an outer finishing layer by use of a panning process.

CHEWING GUMS

The present invention relates to chewing gum containing a synergic combination of zinc and vegetable extracts containing polyphenols. Said chewing gum is useful in treating the symptoms of halitosis.

PRODUCT COMPRISING A NICOTINE-CONTAINING MATERIAL AND AN ANTI-CANCER AGENT

The present invention provides a composition comprising a nicotine-containing material and an anti-cancer agent usable in the treatment and/or prevention or reduction of the risk of cancer and precancerous conditions as well as for preventing or reducing the risk of cancer recurrence. Furthermore, a composition comprising a nicotine-containing material and an anti-inflammatory agent usable in the treatment and/or prevention or reduction of the risk of inflammation, is provided. The nicotine containing composition can also include both an anti-cancer agent and an anti-inflammatory agent A device for administering the composition of the present invention to subjects can be a cigarette, smoking pipe, smokeless tobacco, electronic cigarette, transdermal patch or the like.

ЖЕВАТЕЛЬНАЯ РЕЗИНКА И СПОСОБ ЕЁ ПРОИЗВОДСТВА

Настоящее изобретение относится к порошкообразному составу жевательной резинки, который содержит более 50% вес./вес. основы жевательной резинки, и при этом по меньшей мере 95% вес./вес. частиц состава имеют размер частицы менее 1200 мкм в диаметре. Кроме того, настоящее изобретение относится к применению упомянутого порошкообразного состава жевательной резинки. Также настоящее изобретение относится к жевательной резинке, содержащей а) секцию ядра, б) один или несколько слоев, содержащих состав согласно изобретению. Настоящее изобретение дополнительно относится к способу производства жевательной резинки, включающему стадии, на которых (а) подготавливают состав ядра и (б) покрывают состав ядра порошкообразным составом жевательной резинки с использованием процесса дражирования, и необязательно (в) покрывают внешний промежуточный слой внешним завершающим слоем с использованием процесса дражирования.

ANTISTRESS CONFECTIONERY PRODUCT

Compositions

Compositions, comprising menthofuran and selected menthol compounds which feature improved flavour and odour properties, are provided and, in addition, the production of compositions, specifically, of emulsions with an improved storage stability.

FOOD PRODUCT HAVING A TONGUE COATING-ELIMINATING EFFECT

Heat stress alleviating agent

The present invention addresses the problem of providing a novel heat stress alleviation agent that can be taken simply, safely, and easily, even by infants and the elderly, who are susceptible to heat stress such as heatstroke, that rapidly promotes sweating in heat stress environments, and that prevents, alleviates, or improves symptoms and disorders caused by heat stress, such as heatstroke. Provided are: a heat stress alleviation agent that contains glycosyl hesperidin as an active ingredient; and a basal body temperature maintenance agent that contains glycosyl hesperidin as an active ingredient.

DENTAL ENAMEL RECALCIFICATION ACCELERATOR AND CONTAINING THE SAME, ORAL COMPOSITION AND FOOD OR BEVERAGE

A dental enamel recalcification accelerator that even when used in oral compositions and food or beverage, poses no safety problem, and that is capable of effectively promoting the recalcification of decalcified dental enamel to thereby positively suppress any dental caries; and containing the same, an oral composition and food or beverage. There is provided a dental enamel recalcification accelerator comprising anhydrogalactose-containing red algae and/or an extract thereof as an active ingredient. Further, there are provided an oral composition and food or beverage comprising the dental enamel recalcification accelerator.

PREPARATION OF SOLID CAPSULES COMPRISING FLAVOURS

The present invention relates to a process for the preparation of solid capsules comprising flavours, in which an emulsion comprising flavour or fragrance, a natural extract comprising saponins, water and a water-soluble biopolymer having a molecular weight below 100 KDa is spray-dried. The invention further relates to the solid capsules as such and to products containing them.

COMPOSITION AGAINST PERIODONTAL BACTERIA AND FOODS, DRINKS AND MOUTH WASHERS AGAINST PERIODONTAL BACTERIA CONTAINING THE COMPOSITION

It is intended to provide a composition against periodontal bacteria, which has a high safety without showing any side effects and exhibits an excellent effect of killing periodontal bacteria without affecting the growth of nonpathogenic indigenous microorganisms in the oral cavity, and foods, drinks and mouth washers against periodontal bacteria. A composition against periodontal bacteria is blended with a cocoa fraction contained in cacao mass, a hot water-extract of the cocoa fraction, polyphenols originating in the cocoa fraction or free fatty acids originating in the cocoa fraction as the active ingredient. Then the obtained composition against periodontal bacteria is added to foods, drinks or mouth washers against periodontal bacteria. It is preferable that the above-described cocoa fraction is cocoa and/or cacao mass. It is preferable that the above-described free fatty acids contain at least one member selected from among palmitic acid, stearic acid, oleic acid and linoleic acid ...

Compressed chewing gum tablet

The invention relates to a chewing gum tablet ( 20 ) comprising at least two cohered chewing gum modules ( 21, 22, 23 ), said tableted chewing gum being formed by compression of chewing gum granules, at least one of said chewing gum modules comprising gum base granules, said gum base granules comprising an elastomer system, said chewing gum tablet comprising an elastomer system in an amount of at least 10% by weight of the tablet. According to the invention, a compressed chewing gum tablet has been obtained featuring extremely impressing abilities of incorporating well-defined amounts of chewing gum ingredients combined with acceptable rheological properties of the compete tablet.

ИММУНОМОДУЛИРУЮЩЕЕ СРЕДСТВО, ПРОТИВОРАКОВОЕ СРЕДСТВО И ЗДОРОВАЯ ПИЩА, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ МОНОАЦЕТИЛДИАЦИЛГЛИЦЕРИНА

FIELD: medicine. SUBSTANCE: oral introduction of monoacetyldiacylglycerin derivatives detains development of hamster's induced cancer by activation of lymphocytes, monocytes and dendritic cells, as well as apoptosis induction of cancer cells owing to intensified cytotoxicity of immune cells in relation to cancer cells. Besides, induction of septic shock at mice is accompanied with shown 100% survival rate even in 120 hours, reached by immunity control and suppressing apoptosis effect. Monoacetyldiacylglycerin derivatives according to this invention can be effectively applied as agent for sepsis and cancer treatment and as healthy food preventing cancer or autoimmune diseases. EFFECT: discovers application of monoacetyldiacylglycerin derivatives extracted from antler as agent suppressing cell abnormality resulted from autoresponse. 11 cl, 16 dwg, 11 ex, 6 tbl ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 341 257 (13) C2 (51) ÌÏÊ A61K A61P A61P A61P A61P 31/22 37/02 31/18 35/00 29/00 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2006141418/15, 22.04.2005 (72) Àâòîð(û): ÊÈÌ Ñàíã-Õè (KR) (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 22.04.2005 ïðèîðèòåò: 10-2004-0028514 10-2004-0070650 10-2004-0109805 R U (30) Êîíâåíöèîííûé 24.04.2004 KR 04.09.2004 KR 21.12.2004 KR (73) Ïàòåíòîîáëàäàòåëü(è): ÊÈÌ Ñàíã-Õè (KR) (43) Äàòà ïóáëèêàöèè çà âêè: 27.05.2008 2 3 4 1 2 5 7 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: SUH J.S. at al. Triacylglycerol, 1palmitoyl-2-linoleoyl-3-acetyl-RAC-glycerol isolated from bovine udder and its synthetic enantiomer can potentiate the mitogenic activity for mouse peritoneal macrophages. Cell. Physiol. Biochem. 2003; 13(6):415-22. WO 99/26640 A1, 03.06.1999. RU 2154492 C2, 20.08.2000. WO 99/00116 A2, 07.01.1999. OUYANG Y. at al. (ñì. ïðîä.) C 2 C 2 (45) Îïóáëèêîâàíî: 20.12.2008 Áþë. ¹ 35 2 3 4 1 2 5 7 (85) ...

КОНДИТЕРСКИЙ ПРОДУКТ, СОДЕРЖАЩИЙ АКТИВНЫЕ И/ИЛИ РЕАКЦИОННЫЕ КОМПОНЕНТЫ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ

FIELD: food industry. SUBSTANCE: body part hat multiple capillaries positioned inside the body part. One or more of the said capillary/capillaries is/are at least partly filled with a filling material. The filling material includes an active and/or reaction component volatile at a temperature of 35°C and higher; the said extruded body part fails to contain the said volatile active and/or reaction component. The said volatile active and/or reaction component is chosen from among taste-and-aroma additives, active components for oral cavity care, sweeteners, physiological cooling agents, heating agents, tingling agents, colouring additives, effervescent additives, pharmaceutical agents, nutraceutical agents, vegetal extracts, teeth whitening remedies and the listed components combinations. Additionally, one proposes the said confectionary product manufacture method. According to the method, the confectionary material is extruded at a temperature of 50°C and higher to produce a body with multiple capillaries with subsequent partial filling of them with the filling material. EFFECT: invention allows to ensure prolonged release of an active or reaction component from the capillary. 3 cl, 31 dwg, 3 tbl, 2 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A23G 3/00 (13) 2 572 306 C2 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2014121406/13, 23.03.2011 (24) Дата начала отсчета срока действия патента: 23.03.2011 (72) Автор(ы): КЛАРК Питер (GB), МАРШАЛЛ Сара (GB) (73) Патентообладатель(и): КЭДБЕРИ Ю Кей ЛИМИТЕД (GB) (43) Дата публикации заявки: 10.12.2015 Бюл. № 34 (45) Опубликовано: 10.01.2016 Бюл. № 1 2 5 7 2 3 0 6 R U Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (54) КОНДИТЕРСКИЙ ПРОДУКТ, СОДЕРЖАЩИЙ АКТИВНЫЕ И/ИЛИ РЕАКЦИОННЫЕ КОМПОНЕНТЫ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ (57) Реферат: Предложен кондитерский продукт с охлаждающих агентов, ...

ПИЩЕВЫЕ СОСТАВЫ С МЕДЛЕННЫМ ВЫДЕЛЕНИЕМ

Настоящее изобретение относится к пищевым составам для медленного выделения водорастворимых активных ингредиентов. Пищевой состав содержит водорастворимую сердцевину, содержащую по меньшей мере один активный ингредиент, и внешнее покрытие, полностью покрывающее сердцевину. Внешнее покрытие содержит менее 3% воды. Внешнее покрытие получают путем выпаривания водной дисперсии. Водная дисперсия включает по меньшей мере один виниловый полимер, по меньшей мере один защитный коллоид. Защитный коллоид выбирают из целлюлозы, модифицированной целлюлозы, поливинилового спирта, полиуретанов, крахмалов, модифицированных крахмалов, мальтодекстринов, полисахаридов, пектинов, акриловых полимеров и их смесей. Причем указанная дисперсия и внешнее покрытие свободны от эмульгаторов. Также предложена пищевая композиция, содержащая данный состав. Изобретение позволяет получить пищевые составы для медленного выделения водорастворимых активных ингредиентов без необходимости использования ионных поверхностно-активных ...

МАТЕРИАЛ В ВИДЕ ЧАСТИЦ ДЛЯ КОНТРОЛИРУЕМОГО ВЫСВОБОЖДЕНИЯ АКТИВНЫХ ИНГРЕДИЕНТОВ

FIELD: medicine, pharmaceutics. SUBSTANCE: invention relates to the chemical-pharmaceutical industry and represents a carrier for chewing gum in the form of particles for the controlled release of an active ingredient (ingredients), absorbed in the said carrier and/or adsorbed on it, characterised by the fact, that the said carrier contains 0.1-50 mcm of a calcium carbonate particle, preliminarily processed with an acid, selected from the group, which consists of H 2 SO 4 , HSO 4 -, H 3 PO 4 , oxalic acid and their mixtures, and gaseous CO 2 , and the specific area of surface of BET particles of calcium carbonate is increased to the level more than 15 m 2 /g according to the standard method of measuring the specific area of BET surface. EFFECT: obtaining the carrier for chewing gum. 6 cl, 10 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 530 655 C2 (51) МПК A61K 9/14 (2006.01) A61K 47/02 (2006.01) C01F 11/18 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2011147588/15, 26.04.2010 (24) Дата начала отсчета срока действия патента: 26.04.2010 (72) Автор(ы): ПЕДЕРСЕН Курт Меллер (DK), АНДЕРСЕН Йетте Бэк (DK) (73) Патентообладатель(и): ОМИА ИНТЕРНЭШНЛ АГ (CH) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 27.05.2013 Бюл. № 15 R U 24.04.2009 US 61/172,474 (45) Опубликовано: 10.10.2014 Бюл. № 28 A, 12.05.1998. WO 2005072125 A2, 11.08.2005. WO 2008055006 A1, 08.05.2008. US 5633027 A, 27.05.1997. JP 2002160918 A, 04.06.2002. US 5882631 A1, 16.03.1999. RU 2324472 C2, 20.05.2008 (86) Заявка PCT: C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 24.11.2011 DK 2010/000056 (26.04.2010) (87) Публикация заявки PCT: 2 5 3 0 6 5 5 WO 2010/121620 (28.10.2010) R U 2 5 3 0 6 5 5 (56) Список документов, цитированных в отчете о поиске: GB 1572718 A, 30.07.1980. US 5750086 Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и ...

УСКОРИТЕЛЬ РЕКАЛЬЦИНИРОВАНИЯ ЗУБНОЙ ЭМАЛИ, КОМПОЗИЦИЯ ДЛЯ УХОДА ЗА ПОЛОСТЬЮ РТА И СОДЕРЖАЩИЕ ЕГО ПИЩЕВОЙ ПРОДУКТ ИЛИ НАПИТОК

Изобретение относится к усилителю рекальцинирования зубной эмали, который может быть использован в композиции для ухода за полостью рта. Усилитель рекальцинирования зубной эмали, содержащий в качестве активного ингредиента экстракт красных водорослей, содержащий ангидрогалактозу и представляющий собой по меньшей мере один полисахарид из группы, состоящей из κ-каррагенана, τ-каррагенана и фурцеллерана. Усилитель рекальцинирования зубной эмали, содержащий в качестве активного ингредиента экстракт красных водорослей, содержащий ангидрогалактозу и представляющий собой по меньшей мере один полисахарид из группы, состоящей из κ-каррагенана, τ-каррагенана и фурцеллерана, и ксилит и/или дикальций фосфат. Композиция для ухода за полостью рта, содержащая усилитель рекальцинирования зубной эмали. Пищевой продукт или напиток, содержащий усилитель рекальцинирования зубной эмали. Вышеописанные композиции эффективно усиливают рекальцинирование зубной эмали. 4 н.п. ф-лы, 12 ил., 2 табл.

СПОСОБ ИНКАПСУЛИРОВАНИЯ АКТИВНОГО ИНГРЕДИЕНТА

... 1. Способ приготовления инкапсулированного активного ингредиента в или на съедобной композиции, включающий стадии:a) прибавления к воде или к съедобной композиции, содержащей воду,i) твердых частиц, высвобождающих жидкий активный ингредиент в присутствии воды; иii) инкапсулирующего материала, содержащего пустые клетки микроорганизма; таким образом, чтобы высвободить, по меньшей мере, часть жидкого активного ингредиента, при желании, при нагревании;b) смешивания и, при желании, нагревания композиции, полученной на стадии а) таким образом, чтобы обеспечить тесный контакт высвобожденного жидкого активного ингредиента с инкапсулирующим материалом таким образом, чтобы, по меньшей мере, часть жидкого активного ингредиента была инкапсулирована внутрь инкапсулирующего материала;c) если твердые частицы и инкапсулирующий материал прибавляли к чистой воде на стадии a), смешивания композиции, полученной на стадии a) или на стадии b) в съедобную композицию или нанесения ее на съедобную композицию.2.

ЖЕВАТЕЛЬНАЯ РЕЗИНКА

... 1. Жевательная резинка, состоящая по меньшей мере из первой области с гуммиосновой и по меньшей мере из второй полностью водорастворимой области без гуммиосновы, где указанная жевательная резинка отличается присутствием синергической комбинации:а) эффективного количества растительных экстрактов, выбранных из экстракта коры магнолии, экстракта зеленого чая и их комбинаций,б) эффективного количества ионов цинка, по меньшей мере частично содержащихся в полностью растворимых в воде микрогранулах.2. Жевательная резинка по п. 1, где растительный экстракт представляет собой экстракт коры магнолии, содержащий магнолол и хонокиол предпочтительно в концентрации выше 80% по массе экстракта.3. Жевательная резинка по п. 1, где растительный экстракт представляет собой экстракт зеленого чая, содержащий катехин предпочтительно в концентрации выше 40% по массе экстракта.4. Жевательная резинка по п. 1, где указанные растительные экстракты содержатся в указанной второй области.5. Жевательная резинка по п.

Bonbon oder Kaugummi zur Lippenpflege und/oder -regeneration

Bonbon oder Kaugummi zur Lippenpflege und/oder -regeneration, dass eine pflanzliche und/oder chemische Substanz zur Lippenpflege und/oder -regeneration enthält, dadurch gekennzeichnet, dass durch orale Einnahme und/oder Lutschen und/oder Kauen, die vollständige oder teilweise Auflösung im Mundraum, die Freisetzung der wirkstoffhaltigen Substanz und die Lippenpflege und/oder -regeneration erreicht werden.

CHEWING RUBBER GRANULATES FOR COMPRESSED CHEWING RUBBER

Cooling confectioneries and beverages

A method for the preparation of a chewing gum comprising incorporating a cooling agent having the structure N (CH 2)nOR wherein R is hydrogen or C.-C6 alkyl, and n is 2 or 3,into the chewing gum composition. The cooling agent may be selected from the group consisting of N-(2-hydroxyethyl)-2-isopropyl 2,3-dimethylbutanamide, N-(3-ethoxypropyl)-2isopropyl-2,3-dimethylbutanamide, N-(3 propoxypropyl)-2-isopropyl-2,3-dimethylbutanamide, N-(3-butoxypropyl)-2-isopropyl-2,3 dimethylbutanamide, and combinations thereof.

Cannabis-infused product with enhanced cannabinoid profile user experience

The present disclosure relates to a cannabis-infused product, comprising an emulsion containing a cannabinoid profile including one or more cannabinoid, wherein the emulsion is a nanoemulsion. The disclosure also relates to methods of manufacture and of using same.

CONFECTIONERY COMPOSITION INCLUDING AN ELASTOMERIC COMPONENT AND A COOKED SACCHARIDE COMPONENT

The present invention relates to confectionery compositions including cooked saccharide including polyols such as maltitol, erythritol, and isomalt, and a chewing gum base.

TABLETED CANNABINOID CHEWING GUM WITH LAYERED STRUCTURE

The present invention relates to a tableted chewing gum composition for oral administration of cannabinoids, the composition comprising a plurality of particles, including a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients, and the composition constituting at least two layers, wherein a first layer of the composition comprises water-insoluble gum base and a second layer of the composition, which is cohered to and adjacent to the first layer, comprises water-soluble chewing gum ingredients, the second layer being free of water-insoluble gum base, and wherein the composition comprises one or more cannabinoids.

SYNERGISTIC COMPOSITION COMPRISING PROPOLIS AND CARNOSIC ACID FOR USE IN THE PREVENTION AND TREATMENT OF CANDIDIASIS

Synergistic composition comprising propolis and carnosic acid for use in the prevention and treatment of candidiasis. The invention relates to a synergistic composition comprising propolis that comprises polyphenols at a concentration between 70 and 90 % by weight of propolis and carnosic acid, for use in the prevention and treatment of candidiasis in humans and/or animals. The invention also relates to a synergistic pharmaceutical and/or veterinary composition and a synergistic food product.

METHOD AND COMPOSITIONS FOR PRESERVING WINE

Resveratrol and/or pterostilbene are added to wines to preserve the wine from oxidation, bacteria and fungi. The resveratrol and/or pterostilbene can be added to grape must prior to fermentation and/or to fermented wine prior to bottling.

PRODUCT, INCLUDING ANTITUMOR AGENT NIKOTINSODERZhAShchEE SUBSTANCE AND

ПОРОШКООБРАЗНЫЕ СОСТАВЫ ЖЕВАТЕЛЬНОЙ РЕЗИНКИ, ИХ ИСПОЛЬЗОВАНИЕ И СПОСОБ ПРИГОТОВЛЕНИЯ ТАКИХ СОСТАВОВ

Настоящее изобретение относится к порошкообразному составу жевательной резинки, который содержит более 50% вес./вес. основы жевательной резинки, при этом по меньшей мере 95% вес./вес. частиц состава имеют размер частицы менее 1200 мкм в диаметре. Кроме того, настоящее изобретение относится к применению упомянутого порошкообразного состава жевательной резинки. Также настоящее изобретение относится к жевательной резинке, содержащей а) секцию ядра, б) один или несколько слоев, содержащих состав согласно изобретению. Настоящее изобретение дополнительно относится к способу производства жевательной резинки по одному из пп.10-13, включающий стадии, на которых (а) подготавливают состав ядра, и (б) покрывают состав ядра порошкообразным составом жевательной резинки с использованием процесса дражирования, и необязательно (в) покрывают внешний промежуточный слой внешним завершающим слоем с использованием процесса дражирования.

CHEWING-GUM ENERGISANT.

L'invention vise un chewing-gum énergisant doté de très bonnes qualités organoleptiques. Le but de l'invention est de fournir un chewing-gum énergisant ayant d bonnes qualités organoleptiques et de bonnes propriétés physico-chimiques standards recherchées pour les chewing-gums (notamment cohésion et viscosité à température buccale). Pour atteindre ce but, le chewing-gum selon l'invention comprend une gomme base, des agents sucrants hydrosolubles, des arômes, de la taurine, de la caféine et au moins un agent anti-amertume, le rapport massique taurine/caféine étant de préférence inférieur à 10, et, plus préférentiellement encore, inférieur ou égal à 8. L'invention a également trait au procédé de fabrication d'un tel chewing-gum.

CONFECTIONERY COMPOSITION INCLUDING AN ELASTOMERIC COMPONENT, A COOKED SACCHARIDE COMPONENT, AND A SENSATE

The present invention relates to confectionery compositions including cooked saccharide portion and an elastomeric material portion, each portion also including sensates ...

COMPRESSED CHEWING GUM TABLET

Tablette de chewing gum (20) comprenant au moins deux modules de chewing gum en correspondance (21, 22, 23), le chewing gum étant formé par compression de granules, au moins un des modules comportant des granules à base de gomme, comprenant un système élastomère. La tablette de chewing gum comporte un système élastomère selon une quantité d'au moins 10 % en poids de la tablette. La tablette comprimée de chewing gum de cette invention est remarquable en ce qu'elle permet d'intégrer des quantités bien définies d'ingrédients combinés à des propriétés rhéologiques acceptables pour toute la tablette.

BREATH FRESHENING AND ORAL CLEANSING PRODUCT

Oral products containing the combination of essential oils for oral cleansing, breath freshening and anti-microbial benefits. The combination of essential oils are such that a synergism is observed in anti-microbial activity. The oral products of this invention are chewing gums, confections, mouthwashes, mouth sprays and edible thin film products. In effective amounts, the combination of essential oils is delivered in an oral product for convenient oral cleansing and breath freshening benefits.

CHEWING GUM PREPARATIONS COMPRISING PHYSIOLOGICAL AGENTS

Disclosed are chewing gum compositions containing (a) a basic water-insoluble moiety, (b) a water-soluble moiety, and (c) physiologically active substances selected from among the group comprising (c1) sterols and/or sterol esters, (c2) polyunsaturated fatty acids, the esters and glycerides thereof, and (c3) hoodia extracts or the active steroid glycosides obtained therefrom, and the mixtures thereof.

Confectionery Composition Including an Elastomeric Component and a Cooked Saccharide Component

The present invention relates to confectionery compositions including cooked saccharide including polyols such as maltitol, erythritol, and isomalt, and a chewing gum base.

TRANSFER FACTOR PREPARATIONS AND ASSOCIATED METHODS

A drink includes an edible liquid or semisolid preparation and transfer factor. The drink may also include lactoferrin and one or more preservatives. An edible preparation includes a fruit component and transfer factor. The fruit component may include at least one oligoproanthocyanidin-containing fruit. The edible preparation may also include lactoferrin. One or more preservatives may also be included in the edible preparation. The drink or the edible preparation may be sterilized or pasteurized. 1. A nutritional supplement , comprising:a liquid fruit component of at least one oligoproanthocyanidin-containing fruit, the liquid fruit component comprising an oligoproanthocyanidin; andtransfer factor dissolved in the liquid fruit component and capable of eliciting an immune response in the presence of the oligoproanthocyanidin.2. The nutritional supplement of claim 1 , wherein the liquid fruit component comprises fruit juice.3. The nutritional supplement of claim 1 , wherein the at least one oligoproanthocyanidin-containing fruit comprises açai.4. The nutritional supplement of claim 3 , wherein the liquid fruit component further comprises at least an extract of one or more of elderberry claim 3 , grape claim 3 , and pomegranate.5. The nutritional supplement of claim 1 , wherein the at least one oligoproanthocyanidin-containing fruit comprises at least one of açai claim 1 , elderberry claim 1 , grape claim 1 , and pomegranate.6. The nutritional supplement of claim 1 , wherein the transfer factor comprises at least one of avian transfer factor and bovine transfer factor.7. The nutritional supplement of claim 1 , further comprising:at least one preservative.8. The nutritional supplement of claim 7 , wherein the at least one preservative comprises at least one of lactoferrin claim 7 , lysozyme claim 7 , and lactoperoxidase.9. The nutritional supplement of claim 7 , wherein the liquid fruit component and the transfer factor component are pasteurized.10. A nutritional ...

Monoacetyldiacylglycerol derivative for the treatment of sepsis

The uses of mono acetyl diacyl glycerol derivatives extracted from deer antler for immunomodulating agent disclosed. Medical supplies and health foods containing the same as an effective ingredient also disclosed. Mono acetyl diacyl glycerol derivatives shows significantly effect for immuno modulation including immune enhancing. In the case of inducing cancer in a hamster by injecting cancer cell line, cancer development was delayed by activating lymphocytes, monocytes, and dendritic cells that are important factors to promote immunity and apoptosis of cancer cell was induced by promoting cytotoxicity of immune cell against cancer cell. Also in the case of mouse induced septic shock, it shows 100% survival rate even after lapse of 120 hours by control of immune function and suppression effect apoptosis. Therefore, mono acetyl diacyl glycerol derivatives according to the present invention can be effectively used for an immunomodulating agent, a sepsis treatment, a cancer treatment, and a ...

A COOLING PREPARATION

ЖЕВАТЕЛЬНАЯ РЕЗИНКА С МЯГКИМ ПОКРЫТИЕМ И ПОРОШКООБРАЗНОЙ НАЧИНКОЙ

Изобретение относится к пищевой промышленности. Композиция жевательной резинки содержит сердцевину и один или несколько окружающих слоев. Причем по меньшей мере один из одного или нескольких окружающих сердцевину слоев представляет собой слой жевательной резинки. Сердцевина содержит первый материал в порошкообразной форме со средним размером частиц от 250 до 1000 микрон. При этом самый наружный слой из одного или нескольких слоев содержит покрытие. Указанное покрытие содержит второй материал в порошкообразной форме со средним размером частиц от 60 до 200 микрон. Также предложены продукт жевательной резинки, способ изготовления композиции жевательной резинки и способ доставки двойного холодящего ощущения в ротовую полость потребителя. Изобретение позволяет получить жевательную резинку, дающую холодящее ощущение во рту потребителя и улучшенное вкусовое ощущение за счет последовательного растворения порошкообразных материалов в покрытии и в сердцевине. 4 н. и 11 з.п. ф-лы, 2 ил., 2 табл.

КОНДИТЕРСКИЙ ПРОДУКТ, СОДЕРЖАЩИЙ АКТИВНЫЕ И/ИЛИ РЕАКЦИОННЫЕ КОМПОНЕНТЫ, И СПОСОБЫ ЕГО ПОЛУЧЕНИЯ

Изобретение относится к кондитерской отрасли. Кондитерский продукт содержит экструдированную корпусную часть и множество расположенных в ней капилляров, а также первое создающее ощущение вещество и второе создающее ощущение вещество. Второе вещество отличается от указанного первого создающего ощущение вещества. Вещества размещены в отдельных и ограниченных областях указанного продукта и предназначены для создания профилей последовательного высвобождения. Причем создающие ощущение вещества включают охлаждающие агенты, согревающие агенты, покалывающие агенты, шипучие добавки, а также их комбинации. Изобретение позволяет получить продукт с продолжительным профилем высвобождения двойной начинки. 2 н. и 25 з.п. ф-лы, 31 ил., 3 табл., 2 пр.

СРЕДСТВО ДЛЯ УХОДА ЗА ПОЛОСТЬЮ РТА И ПИЩЕВОЙ ПРОДУКТ ИЛИ НАПИТОК

FIELD: medicine; hygiene. SUBSTANCE: present invention represents an oral care product, a food product or a beverage containing chondroitin sodium sulphate and calcium phosphate. Remineralisation preparation, an oral care agent, a food product, a beverage are characterized by that they contain chondroitin sodium sulphate and hydroxyapatite as active ingredients and have excellent demineralised tooth enamel remineralisation properties. EFFECT: present group of inventions relates to dentistry and discloses an oral care means, a food product, a beverage and a remineralisation preparation. 13 cl, 3 dwg, 65 tbl, 153 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 696 495 C2 (51) МПК A61K 8/24 (2006.01) A61K 8/73 (2006.01) A23G 1/00 (2006.01) A23G 1/30 (2006.01) A23G 1/34 (2006.01) A23G 4/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА A23L 2/52 (2006.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ A23L 33/10 (2016.01) A23L 33/16 (2016.01) A61Q 11/00 (2006.01) (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61K 8/24 (2019.05); A61K 8/73 (2019.05); A23G 1/00 (2019.05); A23G 1/30 (2019.05); A23G 1/34 (2019.05); A23G 4/00 (2019.05); A23L 2/52 (2019.05); A23L 33/10 (2019.05); A23L 33/16 (2019.05); A61Q 11/00 (2019.05) 2017140457, 20.05.2016 (24) Дата начала отсчета срока действия патента: 20.05.2016 02.08.2019 (73) Патентообладатель(и): КАБУСИКИ КАЙСЯ САНГИ (JP) Приоритет(ы): (30) Конвенционный приоритет: 26.05.2015 JP 2015-106298 (43) Дата публикации заявки: 27.06.2019 Бюл. № 18 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 26.12.2017 C 2 C 2 (45) Опубликовано: 02.08.2019 Бюл. № 22 (56) Список документов, цитированных в отчете о поиске: JP 2002-325557 A, 12.11.2002. WO 2012100991 A1, 02.08.2012. JP 7-53388 A, 28.02.1995. WO 2006038315 A1, 31.07.2008. JP 1213222 A, 28.08.1989. CN 102973980, 20.03.2013. (86) Заявка PCT: 2 6 9 6 4 9 5 JP 2016/002470 (20.05.2016) R U 2 6 9 6 4 9 5 Дата регистрации: (72) Автор(ы): ТАКАМАЦУ Риэ (JP), ОБУКИ Марико (JP), КАСУГА Аяко (JP), ТАКИКАВА Римико (JP) R U ...

ПРИГОТОВЛЕНИЕ ТВЕРДЫХ КАПСУЛ, СОДЕРЖАЩИХ ВКУСОАРОМАТИЧЕСКИЕ ВЕЩЕСТВА

... 1. Способ приготовления твердых капсул, включающий стадии:а) приготовления эмульсии, содержащей:- от 0,1 до 10% натурального экстракта, содержащего сапонины;- от 5 до 55%) водорастворимого биополимера с молекулярной массой ниже 100 кДа;- от 5 до 60%) вкусоароматического вещества или ароматизатора; и- от 15 до 80% воды;где проценты являются массовыми процентами к общей массе эмульсии;b) распылительной сушки эмульсии, полученной на стадии (а), до получения твердых капсул.2. Способ по п.1, в котором натуральный экстракт содержит по меньшей мере 10 масс.%) сапонинов к общей массе экстракта.3. Способ по п.1, в котором натуральным экстрактом является растительный экстракт.4. Способ по п.3, в котором натуральным экстрактом является экстракт килайи.5. Способ по п.1, в котором водорастворимым биополимером является гидролизат крахмала с декстрозным эквивалентом выше 2.6. Способ по п.5, в котором водорастворимый биополимер выбран из декстринов, мальтодекстринов и кукурузного сиропа.7. Способ по п.1 ...

ЖЕВАТЕЛЬНАЯ РЕЗИНКИА И ГУММИОСНОВА

... 1. Гуммиоснова, которая образует остаток после жевания и обладает жевательными свойствами при температуре во рту, содержащая пищевой триблок-сополимер с конфигурацией А-В-А или А-В-С, имеющий мягкий средний блок и жесткие концевые блоки, где мягкий средний блок содержит по меньшей мере 30% вес. триблок-сополимера, a T(температура стеклования) каждого жесткого концевого блока ниже 70°С.2. Гуммиоснова по п.1, дополнительно содержащая диблок-сополимер.3. Гуммиоснова по п.1 или 2, которая содержит по меньшей мере один дополнительный ингредиент, выбранный из группы, состоящей из пластификаторов, мягчителей, эмульгаторов, наполнителей, пластичных смол, красителей, антиоксидантов и дополнительных эластомеров.4. Гуммиоснова по п.3, которая содержит в качестве наполнителя 0-5% талька или карбоната кальция.5. Гуммиоснова по п.3, которая содержит в качестве наполнителя 5-40% аморфного диоксида кремния.6. Гуммиоснова по п.3, которая содержит 5-15% высокомолекулярного полиизобутилена.7. Гуммиоснова ...

ЖЕВАТЕЛЬНАЯ РЕЗИНКА

Настоящее изобретение относится к жевательной резинке, содержащей синергическую комбинацию цинка и растительных экстрактов, содержащих полифенолы. Предложенная жевательная резинка состоит из по меньшей мере из первой области с гуммиосновой и по меньшей мере из второй полностью водорастворимой области без гуммиосновы. Указанная жевательная резинка отличается присутствием синергической комбинации из эффективного количества растительных экстрактов и эффективного количества ионов цинка, по меньшей мере частично содержащихся в полностью растворимых в воде микрогранулах. Причем растительные экстракты выбирают из экстракта коры магнолии, экстракта зеленого чая и их комбинаций. А содержание ионов цинка находится в диапазоне от 0,0005% до 0,05% по массе, содержание растительного экстракта находится в диапазоне от 0,02% до 2%. Указанная жевательная резинка полезна в лечении симптомов галитоза. 19 з.п. ф-лы, 4 табл., 3 пр.

Bonbon oder Kaugummi zur Lippenpflege und/oder -regeneration

Herkömmliche Bonbons und Kaugummis dienen nicht der Pflege und/oder Regeneration der Lippen. Der vorliegenden Erfindung liegt daher die Aufgabe zugrunde, Bonbons und Kaugummis zur Verfügung zu stellen, die neben den gängigen Effekten, einen weiteren medizinischen Effekt hervorbringen, nämlich die Pflege und/oder Regeneration der Lippen. Das erfindungsgemäße Bonbon oder Kaugummi enthält neben den üblichen Bonbon- oder Kaugummibestandteilen eine Lippenpflegezubereitung, die aus einem oder mehreren haut- bzw. lippenpflegenden und/oder regenerierenden Stoff/en bestehen kann. Es wird oral eingenommen, löst sich beim Lutschen und/oder Kauen ganz oder teilweise in der Mundhöhle auf, die Wirkstoffe werden freigesetzt, durch die natürliche Feuchtigkeitsversorgung, insbesondere das un- und bewusste Anfeuchten der Lippen mit der Zunge, auf die Lippen bzw. die Lippenhaut übertragen und die Pflege und Regeneration der Lippen erreicht. Ein Bonbon oder ein Kaugummi, kombiniert mit einem Produkt zur Lippenpflege ...

Chewing gum comprising vitamin C

Kaugummi enthaltend Vitamin C zur Verwendung bei der Behandlung von Übelkeitszuständen beim Menschen.

POWDERED CHEWING RUBBER COMPOSITIONS, YOUR USE AND A PROCEDURE FOR THE PRODUCTION OF SUCH COMPOSITIONS

COMPRESSED CHEWING RUBBER TABLET

COMPOSITION AGAINST PERIODONTAL BACTERIA AND FOODS, DRINKS AND MOUTH WASHERS AGAINST PERIODONTAL BACTERIA CONTAINING THE COMPOSITION

Multi-region confectionery

A multi-region confectionery composition includes a first region including a particulate material having a negative heat of solution and a second region at least partially surrounding the first region to create one or more cavities that are filled by the first region. The second region includes a soluble chewable matrix. The multi-region confection can optionally include a third region at least partially surrounding the second region.

Chewing gum containing low dose amounts of water soluble vitamins

Soft coated powder centre-filled gum

The present invention relates to a chewing gum composition that includes one or more layers surrounding a central core, at least one of the one or more layers surrounding the central core is a layer of chewing gum, wherein the central core includes a first material in a powder form having a first average grain size, and wherein the outermost layer of the one or more layers includes a coating that includes a second material in a powder form having a second average grain size.

Chewing gum compositions

A chewing gum base which is cud-forming and chewable at mouth temperature contains a food acceptable tri-block copolymer having the form A-B-A or A-B-C and comprising a soft mid-block which constitutes at least 30 wt.% of the total polymer and hard end-blocks each having a glass transition temperature below 70°C. The tri-block copolymer is optionally plasticized with a compatible di-block copolymer to function as an elastomer system in the gum base.

Cannabinoid chewing gum with high intensity sweeteners

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum comprising water-soluble chewing gum ingredients and water-insoluble gum base, wherein the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum comprising one or more high intensity sweeteners in an amount of 0.01 to 1% by weight of the chewing gum, and wherein the chewing gum comprises one or more cannabinoids.

Tableted cannabinoid chewing gum with layered structure

The present invention relates to a tableted chewing gum composition for oral administration of cannabinoids, the composition comprising a plurality of particles, including a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients, and the composition constituting at least two layers, wherein a first layer of the composition comprises water-insoluble gum base and a second layer of the composition, which is cohered to and adjacent to the first layer, comprises water- soluble chewing gum ingredients, the second layer being free of water-insoluble gum base, and wherein the composition comprises one or more cannabinoids.

CANNABINOID CHEWING GUM WITH IMPROVED RELEASE OF CANNABINOIDS

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum comprising water-soluble chewing gum ingredients mixed into water-insoluble gum base, wherein the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8- 50% by weight of the gum base, and wherein the chewing gum comprises one or more cannabinoids, and wherein the release rate of the one or more cannabinoids is at least 10% by weight of the one or more cannabinoids within the first 5 minutes upon oral administration.

CANNABIS-INFUSED PRODUCT WITH CONTROLLED CANNABINOID PROFILE USER EXPERIENCE

The present disclosure relates to a cannabis-infused product comprising a cannabinoid profile including one or more cannabinoid, a first composition for controlling onset of the cannabinoid profile and a second composition for controlling offset of the cannabinoid profile in a subject having used the cannabis-infused product, wherein the second composition has a delayed onset compared to that one of the first composition. The present disclosure also relates to methods of manufacture and of using same.

CANNABINOID CHEWING GUM WITH HIGH INTENSITY SWEETENERS

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum comprising water-soluble chewing gum ingredients and water-insoluble gum base, wherein the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum comprising one or more high intensity sweeteners in an amount of 0.01 to 1% by weight of the chewing gum, and wherein the chewing gum comprises one or more cannabinoids.

CANNABINOID CHEWING GUM WITH POLYVINYL ACETATE ELASTOMER PLASTICIZERS

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum comprising water-soluble chewing gum ingredients mixed into water-insoluble gum base, wherein the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the one or more elastomer plasticizers comprise one or more polyvinyl acetate elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum comprises one or more cannabinoids.

TABLETED CANNABINOID CHEWING GUM WITH LAYERED STRUCTURE

The present invention relates to a tableted chewing gum composition for oral administration of cannabinoids, the composition comprising a plurality of particles, including a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients, and the composition constituting at least two layers, wherein a first layer of the composition comprises water-insoluble gum base and a second layer of the composition, which is cohered to and adjacent to the first layer, comprises water-soluble chewing gum ingredients, the second layer being free of water- insoluble gum base, and wherein the composition comprises one or more cannabinoids.

SYNERGISTIC ANTIBACTERIAL EFFECTS OF MAGNOLIA BARK EXTRACT AND L-ARGININE, N-LAUROYL ETHYL ESTER ON PLAQUE BIOFILM

The present disclosure relates generally to oral compositions and methods for inhibiting the formation of plaque biofilm by salivary bacteria, and more particularly, to oral compositions comprising a combination of magnolia bark extract (MBE) and L-arginine, Na-lauroyl ethyl ester (LAE). The oral compositions are useful for improving oral health, including inhibiting the formation of plaque biofilm by salivary bacteria and reducing plaque adherence to teeth.

METHOD AND COMPOSITIONS FOR PRESERVING WINE

Resveratrol and/or pterostilbene are added to wines to preserve the wine from oxidation, bacteria and fungi. The resveratrol and/or pterostilbene can be added to grape must prior to fermentation and/or to fermented wine prior to bottling.

MULTI-REGION CONFECTIONERY

A multi-region confectionery composition includes a first region including a particulate material having a negative heat of solution and a second region at least partially surrounding the first region to create one or more cavities that are filled by the first region. The second region includes a soluble chewable matrix. The multi-region confection can optionally include a third region at least partially surrounding the second region.

PROCESS FOR THE MANUFACTURE OF NICOTINE-COMPRISING CHEWING GUM AND NICOTINE-COMPRISING CHEWING GUM MANUFACTURED ACCORDING TO SAID PROCESS

A process for making a nicotine-comprising chewing gum by (i) dispensing a powder portion from a gum-base-comprising powder, (ii) optionally shaping said powder portion into a powder aggregate, and (iii) applying sufficient electromagnetic energy (EM energy) to said powder portion or said powder aggregate to transform said powder portion or said powder aggregate into said chewing gum, whereby said EM energy is Radio Frequency (RF) energy, Micro Wave (MW) energy, InfraRed (IR) energy or Ultraviolet (UV) energy or combinations thereof. The invention also features a chewing gum made by such process. The chewing gum may comprise one or more deposits.

A TRANSMUCOSAL COMPOSITION CONTAINING ANTHOCYANINS FOR ALLEVIATING A VISUAL DISCOMFORT

The present invention relates to a composition comprising a natural extract containing anthocyanins and an agent for enhancing vigilance, and to a method for alleviating visual discomfort related to or caused by oxidative stress comprising administering via transmucosal route the composition of the invention, said composition being in a form adapted to transmucosal administration, said form preferably being a chewing gum, an orodispersible/orodisintegrating tablet or film or a buccal spray.

CONFECTIONERY PRODUCT CONTAINING ACTIVE AND/OR REACTIVE COMPONENTS AND METHODS OF PRODUCTION THEREOF

The invention relates to a confectionery product comprising an extruded body portion, the body portion having a plurality of capillaries disposed therein, one or more of the capillaries being at least partially filled with a fill material which is a different material from that of the extruded body portion, the fill material and optionally the body portion comprising various active and/or reactive components. Some embodiments are designed to provide sequential release profiles. The invention also relates to a process for the manufacture of the same.

CHEWING GUM COMPOSITIONS

A chewing gum base which is cud-forming and chewable at mouth temperature contains a food acceptable tri-block copolymer having the form A-B-A or A-B-C and comprising a soft mid-block which constitutes at least 30 wt.% of the total polymer and hard end-blocks each having a glass transition temperature below 70°C. The tri-block copolymer is optionally plasticized with a compatible di-block copolymer to function as an elastomer system in the gum base.

ALPHA-AMYLASE INHIBITORS: THE MONTBRETINS AND USES THEREOF

Compounds of Formula 1, or salts thereof, are provided. Such compounds or salts may be used as mammalian .alpha.-amylase inhibitors, for the treatment of pre-diabetes, diabetes and/or obesity, or in the treatment or prophylaxis of dental caries and/or plaque. R1, R2, R3', R5, R5', and R7 are independently H, -OH or ¨OR, wherein R is a C1-C6 alkyl, wherein X is H, -OH or a glucopyranosyl moiety, and wherein the compound is not montbretin A or montbretin B. (see formula I) ...

USE OF BAMBOO CONCENTRATE FOR ENHANCING BIOAVAILABILITY OF TAXANE FAMILY DRUGS BY INCREASING CONCENTRATION AND RETENTION TIME OF TAXANE FAMILY DRUGS IN BLOOD PLASMA

PURPOSE: Use of the bamboo concentrate for enhancing bioavailability of taxane family drugs is provided to increase the concentration and retention time of the taxane family drugs in blood plasma, thus increasing in vivo medicinal efficacy of the taxane family drugs. CONSTITUTION: A pharmaceutical composition for enhancing bioavailability of taxane family drugs comprises the taxane family drugs, and the bamboo concentrate for increasing the medicinal efficacy of the taxane family drugs, wherein the taxane family drug is paclitaxel or docetaxel; the pharmaceutical composition is administered orally; and the taxane family drugs have the cancer preventing or treating activity. © KIPO 2006 ...

Compositions of gum to chew in dust, the method and use same of preparation of such compositions

GUM TO CHEW MEDICINAL

CHEWING COMPOSITION COMPRISING COENZYME Q10

Disclosed is a chewing composition which can elute coenzyme Q10 contained in the composition into an oral cavity with high elution rate. Also disclosed is a method for improving the elution of coenzyme Q10 into an oral cavity, specifically a method for eluting coenzyme Q10 contained in a chewing composition into an oral cavity with higher efficiency. Coenzyme Q10 is included in cyclodextrin, and this cyclodextrin-inclusion product is used as a coenzyme Q10 component. Preferably, coenzyme Q10 is contained in the inclusion product in a smaller amount, preferably 40% by weight or less, more preferably 20% by weight.

DENTAL CARE CHEWING GUM COMPRISING SILVER MOIETIES

The invention relates to dental care chewing gum comprising silver as well as to methods for the production thereof.

Cannabinoid chewing gum with improved release of cannabinoids

A chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum including water-soluble chewing gum ingredients mixed into water-insoluble gum base, wherein the gum base includes one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum includes one or more cannabinoids, and wherein the release rate of the one or more cannabinoids is at least 10% by weight of the one or more cannabinoids within the first 5 minutes upon oral administration.

CONTROLLED RELEASE ORAL DELIVERY SYSTEMS

УСКОРИТЕЛЬ РЕКАЛЬЦИНИРОВАНИЯ ЗУБНОЙ ЭМАЛИ И КОМПОЗИЦИЯ ДЛЯ УХОДА ЗА ПОЛОСТЬЮ РТА, И СОДЕРЖАЩИЕ ЕГО ПИЩЕВОЙ ПРОДУКТ ИЛИ НАПИТОК

... 1. Усилитель рекальцинирования зубной эмали, содержащий в качестве активного ингредиента ангидрогалактозу, содержащуюся в красных водорослях и/или экстракт из них. ! 2. Усилитель рекальцинирования зубной эмали, содержащий в качестве активного ингредиента ангидрогалактозу, содержащуюся в красных водорослях и/или экстракт из них и ксилит и/или дикальций фосфат. ! 3. Усилитель рекальцинирования зубной эмали по п.1 или 2, где экстракт красных водорослей, содержащий ангидрогалактозу, представляет собой по меньшей мере один полисахарид из группы, состоящей из κ-каррагенана, τ-каррагенана и фурцеллерана. ! 4. Композиция для ухода за полостью рта, содержащая усилитель рекальцинирования зубной эмали по пп.1-3. ! 5. Композиция для ухода за полостью рта по п.4 с приложенным указанием на усиленный эффект рекальцинирования зубов. ! 6. Пищевой продукт или напиток, содержащий усилитель рекальцинирования зубной эмали по любому из пп.1-3. ! 7. Пищевой продукт или напиток по п.6 с приложенным указанием на ...

ПРИМЕНЕНИЕ КАТИОННЫХ СУРФАКТАНТОВ ДЛЯ ЗАЩИТЫ ПРОТИВ ЭРОЗИИ ЗУБОВ

... 1. Применение катионного сурфактанта, полученного конденсацией жирных кислот и этерифицированных двухосновных аминокислот, имеющего формулу (1): ! ! где ! X- представляет собой противоион, производный неорганической или органической кислоты, предпочтительно, Вr-, Сl- или HSO4 -, или анион на основе фенольного соединения; ! R1 представляет собой прямую алкильную цепь ненасыщенной жирной кислоты или гидроксикислоты, содержащую от 8 до 14 атомов, связанную с α-аминокислотной группой амидной связью; ! R2 представляет собой прямую или разветвленную алкильную цепь, содержащую от 1 до 18 атомов углерода, или ароматическую группу; ! R3 представляет собой ! ! !или ! , ! где n лежит в диапазоне от 0 до 4, ! в качестве защитных средств для защиты зубов от патологической эрозии. ! 2. Применение по п.1, отличающееся тем, что катионный сурфактант используют в форме композиции для перорального применения, такой как сладости, кондитерские изделия, таблетки, пастилки, леденцы, жевательные резинки, конфитюры ...

ЛЕЧЕБНАЯ ЖЕВАТЕЛЬНАЯ РЕЗИНКА

1. Композиция жевательной резинки, содержащая основу жевательной резинки, биологически активный ингредиент, полимерный материал и один или более подсластителей или вкусоароматических добавок, где полимерный материал является амфифильным и имеет неразветвленную или разветвленную углерод-углеродную основную цепь и множество боковых цепей, присоединенных к основной цепи. ! 2. Композиция жевательной резинки по п.1, где основная цепь полимерного материала получена из гомополимера этиленненасыщенного углеводородного мономера или из сополимера двух или более этиленненасыщенных полимеризуемых углеводородных мономеров, а боковые цепи являются гидрофильными. ! 3. Композиция жевательной резинки по п.1, где углерод-углеродная основная цепь полимера получена из гомополимера этиленненасыщенного полимеризуемого углеводородного мономера, содержащего 4 или 5 атомов углерода. ! 4. Композиция жевательной резинки по п.3, где углерод-углеродная основная цепь полимера получена из гомополимера изобутилена, бутадиена или изопрена, ! 5. Композиция жевательной резинки по п.1, где боковые цепи полимерного материала получены из полиэтиленоксида, полиглицина, поливинилового спирта, полистиролсульфоната или полиакриловой кислоты. ! 6. Композиция жевательной резинки по п.1, где боковые цепи присоединены к основной цепи посредством групп, полученных из малеинового ангидрида. ! 7. Композиция жевательной резинки по п.1, где полимерный материал включает боковые группы карбоновой кислоты. ! 8. Композиция жевательной резинки по п.1, где молекулярная масса основной цепи амфифильного полимерного материала находится в диапазоне 10000-200000, пред РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2009 134 941 (13) A (51) МПК A23G 4/08 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2009134941/13, 26.02.2008 (71) Заявитель(и): РЕВОЛИМЕР ЛИМИТЕД (GB) (43) Дата публикации заявки: 10.04.2011 Бюл. № 10 (72) Автор(ы): ФОСТЕР Бет Мери (GB), ...

ATEMERFRISCHER UND MUNDPFLEGEPRODUKT UNTER VERWENDUNG VON KARDAMOM L

BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING CARDAMOM OIL

Chewing Gum And Particulate Material For Controlled Release Of Active Ingredients

A particulate material for controlled release of active ingredients includes a combination of one or more active ingredients, including nicotine, and an inorganic mineral filler, in which the active ingredient is reversibly absorbed into and/or adsorbed onto the inorganic mineral filler, and the BET specific surface area of the inorganic mineral filler is above 15 m 2 /g, the BET specific surface area measured in accordance with ISO 9277. Further, a chewing gum having the particulate material includes a combination of one or more active ingredients, such as nicotine or a flavoring agent, and an inorganic mineral filler. Finally, the method of producing the chewing gum is provided. The invention is particularly advantageous for controlled release of active ingredients.

Chewing gum having sustained release of nicotine

The present invention relates to a chewing gum having a high Surface Area to Volume ratio (SAV ratio), wherein said chewing gum comprises a water insoluble gum base matrix, a water soluble bulk portion and nicotine, wherein the gum base matrix, nicotine and the bulk portion are mixed and extruded to form a final extruded chewing gum product having a SAV ratio above 0.7, and wherein sustained release of nicotine is facilitated by adding 0.1-10% of C8-C10 triglycerides by weight of the chewing gum.

SLOW-RELEASE DIETARY FORMULATIONS

The present invention relates to dietary formulations for the slow release of water-soluble active ingredients. Said formulations comprise a coating obtained by evaporation from vinyl polymer dispersions not containing emulsifiers. The formulations can be advantageously included in an edible composition, including confectionery products. 2. A formulation as claimed in wherein an intermediate coating characterised by lower water-solubility than that of core a) is inserted between core a) and outer coating b).3. A formulation as claimed in wherein the intermediate coating substantially consists of a fat of animal or vegetable origin or a synthetic fat claim 2 , selected from completely hydrogenated claim 2 , partially hydrogenated or fractioned fats.4. A formulation as claimed in wherein the intermediate coating has a solid state percentage higher than 70% at 40° C.5. A formulation as claimed in wherein the active ingredient is selected from a flavour in solid form claim 1 , an acid claim 1 , a vitamin claim 1 , a mineral salt claim 1 , a herbal extract claim 1 , a sweetening agent and combinations thereof.6. A formulation as claimed in wherein the acid is selected from the following acids: adipic claim 5 , citric claim 5 , fumaric claim 5 , lactic claim 5 , malic claim 5 , oxalic claim 5 , succinic claim 5 , tartaric and combinations thereof.7. A formulation as claimed in wherein the flavour is carried by a formulation comprising gum arabic claim 5 , maltodextrin claim 5 , starch claim 5 , modified starches claim 5 , carbohydrates claim 5 , polyalcohols claim 5 , gelatin claim 5 , pectin claim 5 , cellulose claim 5 , modified celluloses claim 5 , vegetable gums claim 5 , and combinations thereof.8. A formulation as claimed wherein the active ingredient percentage is higher than 50% of the weight of the formulation.9. A formulation as claimed in wherein the percentage of the outer coating b) is higher than 10% by weight of the formulation and lower than 50%.10. A ...

Oral composition

In the conventional methods for suppressing dental caries using antibacterial agents, enzyme inhibitors or antibiotics, exocellular polysaccharides in oral biofilm prevent the permeation of antibacterial agents, enzyme inhibitors, antibiotics, or the like, and it is thus difficult to render intended suppressive effects on dental caries. Further, use of antibacterial agents or the like involves a high risk of resistant bacteria emergence, and thus it is not preferable. Thus, there remains a need for the development of a safer and more effective method for suppressing dental caries by regulating biofilm formation caused by dental caries causative bacteria instead of controlling the dental caries causative bacteria. A composition which regulates a quorum sensing according to the present invention can provide the inhibition of the tooth decay biofilm formation.

COMPOSITIONS AND METHODS FOR PROMOTING GROWTH OF BENEFICIAL MICROBES TO TREAT OR PREVENT DISEASE OR PROLONG LIFE

Inoculation of ATM-deficient mice with probiotic microorganisms, such as , changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone disease, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation, Compositions and methods of the invention can increase lifespans in a simple, non-invasive manner. 197-. (canceled)98Lactobacillus johnsonii. A food or beverage product comprising 456.991. The food or beverage product of claim , wherein the product is a nutritional whole food , drink , mineral water , soup , replacement food , nutritional bar , confectionery , fermented or unfermented milk-based product , yoghurt product , milk-based powder , enteral nutritional product , baby and/or infant composition , fermented or unfermented cereal-based product , ice cream , chocolate , coffee , mayonnaise , tomato puree , salad dressing , milk , yoghurt , cheese , fermented milks , milk-based fermented products , ice creams , cereal-based products , fermented cereal-based products , milk-based powders , baby and infant formulas , food product of confectionery type , chocolate , cereals or animal feed.100. The food or beverage product of claim 98 , wherein the product is a fermented or unfermented milk-based product.101. The food or beverage product of claim 98 , wherein the product is yogurt.102. The food or beverage product of claim 98 , wherein the product is milk.103. The food or beverage product of claim 98 , wherein the product is animal feed or food supplements for non-human animals.104. The food or beverage product of claim 98 , wherein the product is chocolate.105. The food or beverage product of claim 98 , wherein the composition further ...

Oral dosage form containing theobromine-free cocoa

Disclosed are stable dosage forms for oral administration of active pharmaceutical ingredients in which any unpleasant taste sensation, caused by release of the active pharmaceutical ingredient and/or of the excipients in the oral and pharyngeal cavity of the patient, is masked by the use of theobromine-free cocoa.

PLATED YEAST FORMULATIONS

Provided herein is a composition comprising: a) about 25% up to about 75% of a plasmolysed micro-organism by weight of the total weight of the composition; b) about at least greater than 20% up to about 60% by weight flavor or fragrance, of the total weight of the composition c) about 1% up to about 25% desiccant; d) about 4% up to about <10% water; wherein the mean particle size distribution by weight of the composition is about greater than 100 micrometer up to about 1 millimeter. Also provided herein is a method of making a plated yeast composition comprising a. blending: i) a homogenous cake, wherein the cake is made by mixing, at a temperature that ranges from 20° C. to about 90° C. a) a plasmolysed micro-organism in an amount of from about 0.01% to about 90% by weight of the total weight of the cake; b) a flavor or fragrance oil provided in an amount of from at least 0.01% up to about 60% by weight of the total weight of the cake; and c) water provided in an amount of from about 5% up to about 90% by weight of the total weight of the cake; wherein the micro-organism to water ratio in the cake is provided in an amount, by weight, of about 4.5:1 to 0.5:1; with ii) at least about 40% up to about 99.9%, by weight desiccant, of the total weight of the composition; iii) optionally from about 0.2 to about 2% by weight a flow agent of the total weight of the composition to form a uniform mixer. b. sifting the blended mixer to form a powder with a particle size about 100 to 1,000 micrometer. 1. A composition comprising:a) 25% up to 75% of a plasmolysed micro-organism by weight of the total weight of the composition;b) at least greater than 20% up to 60%, by weight flavor or fragrance, of the total weight of the composition,c) 1% up to 25% desiccant; andd) 4% up to about less than 10% water; wherein the mean particle size distribution by weight of the composition is greater than 100 micrometer up to 1 millimeter.2. The composition as recited in claim 1 , wherein the ...

Method Of Protecting Teeth Against Erosion

Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages.

COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S)

The present invention primarily relates to the use of one or more specific compounds and/or one or more respective salt(s) thereof for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of such compound(s) and/or salt(s) and one or more cosmetically and/or pharmaceutically acceptable carriers. 118-. (canceled)23. The method according to claim 19 , further comprising administering one or more substances selected from the group consisting of:(i) anti-itch compounds,(ii) steroidal anti-inflammatory substances of the corticosteroid type,(iii) non-steroidal anti-inflammatory substances,(iv) natural or naturally occurring anti-inflammatory substances or substances that alleviate reddening and/or itching,(v) alpha-bisabolol, apigenin, apigenin-7-glucoside, gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols, natural avenanthramides, non-natural avenanthramides, preferably dihydroavenanthramide D, boswellic acid, phytosterols, glycyrrhizin, glabridin and licochalcone A,(vi) skin care agents,(vii) physiological cooling agents, and(viii) histamine receptor antagonists, serine protease inhibitors, TRPV1 antagonists, NK1 antagonists, cannabinoid receptor agonists and TRPV3 antagonists.24. The method according to claim 19 , wherein said one or more compounds of formula 1 and/or salt(s) thereof is present in an amount sufficient to prevent claim 19 , reduce or alleviate one or more itchy skin conditions.25. The method according to claim 19 , wherein the compound(s) and/or salt(s) thereof claim 19 , is applied to skin claim 19 , and remains on the skin for at ...

MEDICAL CHEWING GUM

The invention relates to a medical chewing gum comprising gum base polymers and an active pharmaceutical ingredient, the gum base polymers comprising polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight, wherein the gum base polymers include 20-95% by weight of polyvinyl acetate and -80% by weight of vinyl laurate-vinyl acetate copolymer, and wherein the chewing gum contains no polyterpene resins and no resins based on gum rosin, wood rosin or tall oil resin. 162-. (canceled)63. A medical chewing gum comprising gum base polymers and an active pharmaceutical ingredient ,the gum base polymers comprising polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight,wherein the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer, andwherein the chewing gum contains no polyterpene resins and no resins based on gum rosin, wood rosin or tall oil resin.64. The medical chewing gum according to claim 63 , the medical chewing gum comprising gum base polymers and an active pharmaceutical ingredient claim 63 ,the gum base polymers consisting of synthetic gum base polymers, andthe gum base polymers comprising polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight,wherein the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer, andwherein the chewing gum contains no polyterpene resins and no resins based on gum rosin, wood rosin or tall oil resin.65. The medical chewing gum according to claim 63 , the medical chewing gum comprising gum base polymers claim 63 , an active pharmaceutical ingredient and buffer claim 63 ,the gum base polymers comprising polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight,wherein the gum base polymers include 20-95% by weight of ...

SYNERGISTIC COMPOSITION COMPRISING PROPOLIS AND CARNOSIC ACID FOR USE IN THE PREVENTION AND TREATMENT OF CANDIDIASIS

Synergistic composition comprising propolis and carnosic acid for use in the prevention and treatment of candidiasis. The invention relates to a synergistic composition comprising propolis that comprises polyphenols at a concentration between 70 and 90% by weight of propolis and carnosic acid, for use in the prevention and treatment of candidiasis in humans and/or animals. The invention also relates to a synergistic pharmaceutical and/or veterinary composition and a synergistic food product. 1. A synergistic composition comprising:propolis comprising polyphenols at a concentration between 70 and 90% by weight of the propolis andcarnosic acid,for use in the prevention and treatment of candidiasis in humans and/or animals.2. Synergistic composition for use according to claim 1 , wherein the candidiasis is epithelial candidiasis.3. Synergistic composition for use according to claim 1 , wherein the concentration of propolis is between 20 and 80% by weight relative to the total of the synergistic composition.4. Synergistic composition for use according to claim 1 , wherein the concentration of carnosic acid is between 10 and 60% by weight relative to the total of the synergistic composition.5. Synergistic composition for use according to claim 1 , wherein the synergistic composition is provided in the form selected from the group consisting of cream claim 1 , gel claim 1 , ointment claim 1 , vaginal suppositories claim 1 , sprays claim 1 , tablets claim 1 , powders for topical use claim 1 , capsules claim 1 , powder for oral suspension claim 1 , ear drops claim 1 , toothpaste claim 1 , mouthwash claim 1 , perfusion claim 1 , syrup claim 1 , wipes claim 1 , dental thread claim 1 , dental floss claim 1 , toothbrush and interdental brush.6. Synergistic pharmaceutical and/or veterinary composition comprising:propolis comprising polyphenols at a concentration between 70 and 90% by weight of the propolis andcarnosic acid,together with pharmaceutically and/or veterinarily ...

CONFECTIONERY PRODUCT CONTAINING ACTIVE AND/OR REACTIVE COMPONENTS AND METHODS OF PRODUCTION THEREOF

The invention relates to a confectionery product comprising an extruded body portion, the body portion having a plurality of capillaries disposed therein, one or more of the capillaries being at least partially filled with a fill material which is a different material from that of the extruded body portion, the fill material and optionally the body portion comprising various active and/or reactive components. Some embodiments are designed to provide sequential release profiles. The invention also relates to a process for the manufacture of the same. 1. A confectionery product comprising an extruded body portion , the body portion having a plurality of capillaries disposed therein , one or more of said capillaries being at least partially filled with a fill material comprising an active and/or reactive component that is volatile at temperatures of 35° C. and higher , and wherein said extruded body portion is essentially free of said volatile active and/or reactive component.2. A confectionery product comprising an extruded body portion , the body portion having a plurality of capillaries disposed therein , one or more of said capillaries being at least partially filled with a fill material comprising an active and/or reactive component that degrades when subjected to manufacturing conditions comprising exposure to temperatures of 50° C. and higher , wherein said extruded body portion is essentially free of said degradable active and/or reactive component.3. A confectionery product for imparting a perception of satiety comprising an extruded body portion , the body portion having a plurality of capillaries disposed therein , one or more of said capillaries being at least partially filled with a fill material comprising a satiety agent and wherein two or more different satiety agents are provided in the same or different capillaries , said satiety agents being selected from the group consisting of sweet flavors , savory flavors , green tea extract , caffeine , ...

Method Of Protecting Teeth Against Erosion

Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages. 1. A single-phase dentifrice composition comprising:a. stannous fluoride;b. tripolyphosphate;c. a silica abrasive;d. a humectant selected from the group consisting of glycerin, sorbitol, polyethylene glycol, propylene glycol, and mixtures thereof;e. from about 0.25% to about 12%, by weight of the composition, of cocamidopropyl betaine;f. from about 0.25% to about 12%, by weight of the composition, of sodium lauryl sulfate; andg. from about 10% to about 50%, by weight of the composition, of water.2. The single-phase dentifrice composition of claim 1 , wherein the composition comprises from about 0.005% to about 5% claim 1 , by weight of the compositions claim 1 , of a sweetening agent.3. The single-phase dentifrice composition of claim 1 , wherein the humectant comprises glycerin.4. The single-phase dentifrice composition of comprising from about 1% to about 35% claim 1 , by weight of the composition claim 1 , of the tripolyphosphate.5. The single-phase dentifrice composition of claim 1 , comprising about 0.454% claim 1 , by weight of the composition claim 1 , of stannous fluoride.6. The single-phase dentifrice composition of claim 1 , wherein the composition has a pH of from about 4 to about 10.7. The single-phase dentifrice composition of claim 1 , wherein the composition comprises sodium carboxymethylcellulose.8. The single-phase dentifrice composition of claim 2 , wherein the sweetening agent comprises saccharin.9. The single-phase dentifrice composition of claim 8 , wherein the composition comprises from about 0.25% to about 5% claim 8 ...

Replacement Therapy for Dental Caries

The invention provides recombinant strains that can be used to improve oral health. An embodiment of the invention provides a method of reducing the incidence or severity of dental caries in a dental caries-susceptible host comprising administering orally to the host an isolated recombinant strain of the invention in an amount effective for replacement of dental caries-causing host strains in the oral cavity of the host. The isolated recombinant strain 10 can be contained in a mouthwash, toothpaste, chewing gum, floss, chewable tablet, food, or beverage. 2Streptococcus mutans. The isolated recombinant strain of claim 1 , wherein the mutacin comprising Formula I further comprises a Trp4insAla mutation or a ΔTrp4 mutation.3Streptococcus mutans. The isolated recombinant strain of claim 1 , wherein the following amino acid substitutions are present: Abu8Ala claim 1 , or Dhb14Ala claim 1 , or both Abu8Ala and Dhb14Ala in the lantibiotic comprising Formula I.4Streptococcus mutansS. mutans. The isolated recombinant strain of claim 1 , further comprising a mutation in a polynucleotide involved in ComE claim 1 , ComC or both ComE and Com C synthesis such that expression of ComE claim 1 , ComC claim 1 , or both ComE and ComC is diminished by about 80% or more as compared to a wild-type strain.5Streptococcus mutansStreptococcus mutans. The isolated recombinant strain of claim 1 , further comprising a mutation in a polynucleotide involved in D-amino acid synthesis such that expression of the D-amino acid is diminished by about 80% or more as compared to a wild-type strain.6Streptococcus mutans. The isolated recombinant strain of claim 5 , wherein the polynucleotide is dal or a promoter for dal.7Streptococcus mutansZymomonas mobilisStreptococcus mutans. The isolated recombinant strain of claim 1 , wherein the recombinant alcohol dehydrogenase polynucleotide is a alcohol dehydrogenase polynucleotide or a alcohol dehydrogenase polynucleotide.8Streptococcus mutansStreptococcus ...

CANNABINOID AND SUGAR ALCOHOL COMPLEX, METHODS TO MAKE AND USE

The present invention generally relates to a sugar alcohol and cannabinoid complex, and methods to prepare this complex from cannabinoid oil comprising at least one cannabinoid. The complex is in solid form and may be used in food, pharmaceutical, cosmetic formulations, and medical devices wherein solid forms of cannabinoid are desirable. This complex also enhances release of active cannabinoids in oral consumption. Methods to make this complex are also disclosed. 1. A method to prepare a cannabinoid and sugar or cannabinoid and sugar alcohol complex comprising the steps of:adding at least one cannabinoid into a solvent and stir into a mixture;adding sugar alcohol or mixture of sugar alcohols into the cannabinoid-solvent mixture above to form a cannabinoid and sugar alcohol slurry;placing the cannabinoid and sugar alcohol slurry in a container;stirring the cannabinoid and sugar alcohol slurry for at least 15 minutes to form a uniform mixture;applying heat to the container to raise temperature while applying vacuum to reduce the internal pressure in the container;collecting evaporated solvent in a cold trap;stopping the heat and vacuum application; andharvesting the cannabinoid and sugar alcohol solid mixture.2. The method of claim 1 , wherein the solvent is selected from the group consisting of isopropyl alcohol and ethanol.3. The method of claim 1 , wherein the sugar alcohol is selected from the group consisting of isomalt claim 1 , mannitol claim 1 , sorbitol claim 1 , xylitol claim 1 , lactitol claim 1 , maltitol claim 1 , and erythritol.4. The method of claim 1 , wherein the at least one cannabinoid is selected from the group consisting of Δ-tetrahydrocannabinol claim 1 , cannabidiol claim 1 , cannabinol claim 1 , and cannabigerol.5. The method of claim 1 , wherein the temperature is between 45° C. to 60° C.6. The method of claim 1 , wherein the internal pressure in the container is between 100 mmHg to 300 mmHg.7. The method of claim 1 , wherein the at least one ...

Composition for preventing or treating stroke or degenerative brain disease

The present invention relates to a composition for preventing and/or treating a stroke or a degenerative brain disease comprising: at least two substances selected from the group consisting of egg yolk lecithin, glycerol, sodium oleate, medium chain triglyceride and refined fish oil; olive oil; and soybean oil. The composition of the present invention has an excellent neuroprotective effect but no toxicity or side effects, and thus can be effectively and safely used for preventing, treating or ameliorating a stroke or a degenerative brain disease.

AMYLASE INHIBITOR COMPOUNDS, METHODS OF THEIR USE AND COMPOSITIONS THEREOF

There are provided compounds of Formula I: 4. The method of claim 1 , wherein the polyethelene glycol comprises 1-5 CHCHO subunits.5. The method of claim 1 , wherein the polyethelene glycol comprises 2-3 CHCHO subunits.6. The method of claims claim 1 , wherein Q is a xylose.7. The method of claim 1 , wherein Q is H.8. The method of claim 1 , wherein Q is OH.10. The method of claim 1 , wherein the mammalian α-amylase is a salivary α-amylase or pancreatic α-amylase.11. The method of claim 1 , wherein the subject is a human.12. The method of wherein the inhibition of the mammalian α-amylase is for the treatment or prophylaxis of dental caries or plaque.13. The method of claim 11 , wherein the inhibition of the mammalian α-amylase is for the treatment or prophylaxis of pre-diabetes claim 11 , diabetes or obesity.14. The method of claim 11 , wherein the administering of the compound of Formula I or a salt thereof to a subject in need thereof is in an effective amount for the treatment or prophylaxis of pre-diabetes claim 11 , diabetes or obesity or for the treatment or prophylaxis of dental caries or plaque. This application is a divisional application of U.S. application Ser. No. 15/661,883, filed on Jul. 27, 2017; which claims the benefit of U.S. Provisional Patent Application Ser. No. 62/367,360 filed on 27 Jul. 2016 entitled “AMYLASE INHIBITORS”.The present invention relates to compounds, methods and compositions for the inhibition of amylase. The present invention further provides compounds, methods and compositions for the inhibition of inhibition of mammalian salivary or pancreatic α-amylase for the treatment or prophylaxis of dental caries and/or plaque or for the treatment or prophylaxis of pre-diabetes, diabetes and/or obesity.Human pancreatic α-amylase (HPA) is an endoglycosidase that cleaves the α-1,4 linked glucose molecules within starch to produce maltose and a range of additional small α-1,4 and α-1,6-linked oligosaccharides that are then further broken ...

MEANS AND METHODS FOR PREVENTING AND/OR TREATING CARIES

The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to , wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: 133-. (canceled)35. The composition of claim 34 , wherein the feed composition is a pet feed for dogs claim 34 , cats claim 34 , and rats claim 34 , a cattle feed for cows and pigs claim 34 , chicken feed for chicken and turkeys claim 34 , or a fish cultivation feed for porgy and yellowtail.36. The composition of claim 34 , wherein the at least one orally acceptable carrier or excipient comprises a raw feed material selected from the group consisting of cereals claim 34 , brans claim 34 , oil-seed meals claim 34 , animal-derived raw feed materials claim 34 , and combinations thereof.37. The composition of claim 34 , wherein the at least one orally acceptable carrier or excipient comprises a cereal selected from the group consisting of mile claim 34 , wheat claim 34 , barley claim 34 , oats claim 34 , rye claim 34 , brown rice claim 34 , buckwheat claim 34 , fox-tail millet claim 34 , Chinese millet claim 34 , Deccan grass claim 34 , corn claim 34 , soybean claim 34 , and combinations thereof.38. The composition of claim 34 , wherein the at least one orally acceptable carrier or excipient comprises a bran selected from the group consisting of rice bran claim 34 , defatted rice bran claim 34 , bran claim 34 , lowest-grade flour claim 34 , wheat germ claim 34 , barley bran claim 34 , screening pellet claim 34 , corn bran claim 34 , corn germ claim 34 , and combinations thereof.39. The composition of claim 34 , wherein the at least one orally acceptable carrier or excipient comprises an oil-seed meal selected ...

SOFT, CHEWABLE AND ORALLY DISSOLVABLE AND/OR DISINTEGRABLE PRODUCTS

A soft, chewable and orally dissolvable and/or disintegrable product includes a biopolymer-sugar based matrix and botanical powder dispersed throughout the biopolymer-sugar based matrix. The biopolymer-sugar based matrix includes at least one biopolymer, at least one sugar and optional additives. Soft, chewable and orally dissolvable and/or disintegrable product can also include flavor beads. 1. A pre-portioned , soft , chewable and orally dissolvable and/or disintegrable product comprising botanical powder distributed in a biopolymer-sugar based matrix , produced by a method comprising:dissolving a biopolymer and a sugar in water to form a solution;adding botanical powder to the solution;stirring the solution to form a suspension;gelling the suspension to form a gel;drying the gel to form a dried gel; andportioning the dried gel to form a pre-portioned, soft, chewable, and orally dissolvable and/or disintegrabable product,wherein the botanical powder is distributed in a biopolymer-sugar based matrix.2. The product of claim 1 , wherein the biopolymer is selected from the group consisting of gellan gum claim 1 , konjac gum claim 1 , modified starch claim 1 , pectin claim 1 , carrageenan claim 1 , guar gum claim 1 , xanthan gum claim 1 , locust bean gum claim 1 , agar claim 1 , gum Arabic claim 1 , alginate claim 1 , cellulose and combinations thereof.3. The product of claim 1 , comprising claim 1 , in weight percent claim 1 , about 30% to about 75% of the botanical powder claim 1 , about 1% to about 35% of the biopolymer claim 1 , about 2% to about 60% of the sugar and up to about 10% additives.4. The product of claim 1 , wherein the botanical powder is selected from the group consisting of tobacco powder claim 1 , coffee powder claim 1 , tea powder claim 1 , herb powder claim 1 , spice powder claim 1 , cocoa powder and combinations thereof.5. The product of claim 1 , wherein the sugar is selected from the group consisting of monosaccharides including fructose claim ...

METHOD FOR MANUFACTURING MEDICATED CHEWING GUM WITHOUT COOLING

An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapcutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described. 1. A method for manufacturing chewing gum including at least one therapeutically active ingredient , comprising the steps of:placing one or more gum base(s) in a container with a sugar alcohol in an oven and heating said container until said gum base(s) melts to an internally measured temperature between 140-160 deg F;mixing in a commercial mixer one or more active ingredient(s), sugar alcohol(s), and flavorings within a range of from 3 to 7 minutes;adding the melted gum base into the mixer and mixing within a range of from 2 to 6 minutes until a homogeneous mass is produced;conditioning said homogenous mass for at least 6 hours at a temperature not greater than 75 deg F and 60% relative humidity;milling the dried mass into particulates at room temperature using a mesh screen of appropriate particle size ranging between 0.10 inch to 0.30 inch;mixing the particulates with lubricants in an orbital or planetary mixer within a range of from 2 to 4 minutes; andtableting the powder by a tablet press.2. The ...

Oral preparation

The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host. The invention also provides a polypeptide having methyl mercaptan oxidase activity, wherein said polypeptide is: (a) a polypeptide comprising an amino acid sequence as set out in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence having at least 50% sequence identity with the amino acid sequence of SEQ ID NO: 2; (c) a polypeptide encoded by a polynucleotide comprising the polynucleotide sequence as set out in SEQ ID NO: 1 or SEQ ID NO: 3; or (d) a fragment of a polypeptide as defined in (a), (b) or (c).

CHEWING GUMS

The present invention relates to chewing gum containing a synergic combination of zinc and vegetable extracts containing polyphenols. 1. Method of treating halitosis symptoms in a patient in need thereof , said method comprising;placing in oral cavity of a patient with halitosis a piece of chewing gum comprising at least a first region with gum base and at least a second fully water-soluble region without gum base, said gum being characterized by the presence of a synergic combination of:{'i': 'magnolia', 'a) an effective amount of vegetable extracts selected from bark extract, green tea extract and combinations thereof;'}b) an effective amount of zinc ions, at least partly contained in fully water-soluble microgranules; andchewing said chewing gum.2magnolia. The method according to claim 1 , wherein the vegetable extract is bark extract comprising magnolol and honokiol claim 1 , in a concentration higher than 80% by weight of the extract.3. The method according to claim 1 , wherein the vegetable extract is green tea extract comprising catechin in a concentration higher than 40% by weight of the extract.4. The method according to claim 1 , wherein said vegetable extracts are contained in said second region.5. The method according to claim 1 , wherein said vegetable extracts are contained in said first region.6. The method according to claim 1 , wherein zinc in contained in said first region.7. The method according to claim 1 , wherein said water-soluble microgranules comprise one or more polyalcohols claim 1 , hydrocolloids claim 1 , flavours claim 1 , dyes claim 1 , sweeting agents and excipients claim 1 , alone or in mixture thereof claim 1 , said microgranules having an average particle-size distribution lower than 1000 μm.8. The method according to claim 1 , wherein the zinc ion content ranges from 0.0005% to 0.05% by weight and the vegetable extract content ranges from 0.02% to 2%.9magnolia. The method according to containing per single portion zinc ions from 0 ...

Composition for oral cavity and food product, or beverage

It is an object to provide an oral composition, a food, or a beverage and a remineralizing agent having excellent action of remineralizing demineralized tooth enamel. The present invention is an oral composition, a food, or a beverage comprising sodium chondroitin sulfate and a calcium phosphate. The present invention is a tooth remineralizing agent comprising sodium chondroitin sulfate and a calcium phosphate as active ingredients.

Method of Protecting Teeth Against Erosion

Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages.

SOFT, CHEWABLE AND ORALLY DISSOLVABLE AND/OR DISINTEGRABLE PRODUCTS

A soft, chewable and orally dissolvable and/or disintegrable product includes a biopolymer-sugar based matrix and botanical powder dispersed throughout the biopolymer-sugar based matrix. The biopolymer-sugar based matrix includes at least one biopolymer, at least one sugar and optional additives. Soft, chewable and orally dissolvable and/or disintegrable product can also include flavor beads. 1. A pre-portioned , soft , chewable and orally dissolvable and/or disintegrable product comprising botanical powder distributed in a biopolymer-sugar based matrix.2. The product of claim 1 , wherein the biopolymer is selected from the group consisting of gellan gum claim 1 , konjac gum claim 1 , modified starch claim 1 , pectin claim 1 , carrageenan claim 1 , guar gum claim 1 , xanthan gum claim 1 , locust bean gum claim 1 , agar claim 1 , gum Arabic claim 1 , alginate claim 1 , cellulose and combinations thereof.3. The product of claim 1 , comprising claim 1 , in weight percent claim 1 , about 30% to about 75% of the botanical powder claim 1 , about 1% to about 35% of the biopolymer claim 1 , about 2% to about 60% of the sugar and up to about 10% additives.4. The product of claim 1 , wherein the botanical powder is selected from the group consisting of tobacco powder claim 1 , coffee powder claim 1 , tea powder claim 1 , herb powder claim 1 , spice powder claim 1 , cocoa powder and combinations thereof.5. The product of claim 1 , wherein the sugar is selected from the group consisting of monosaccharides including fructose claim 1 , glucose and xylose; disaccharides including sucrose claim 1 , trehalose and lactose; trisaccharides; polysaccharides; oligosaccharides including fructan and inulins; sugar alcohols including sorbitol claim 1 , xylitol claim 1 , lactitol and maltitol; and combinations thereof.6. The product of claim 1 , wherein the botanical powder has dimensions of less than about 50 mesh.7. The product of claim 1 , wherein the soft claim 1 , chewable and orally ...

Physiological cooling compounds

Physiological cooling compounds of the structure: where R 1 is p-menthyl or 2,3,4-trimethylpent-3-yl group and R 2 -R 8 are hydrogen or alkyl groups. The combination of R 2 -R 8 is such that the N-alkyl group is a branched C 5 alkyl or branched or linear C 6 -C 8 alkyl group. The new carboxamides are valuable sensory ingredients which provide long-lasting cooling sensation and freshness in personal care, oral care, cosmetic products, pharmaceutical preparations, confectionary, food and beverages.

Method Of Protecting Teeth Against Erosion

Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages. 1. A single-phase dentifrice composition comprisinga. stannous fluoride;b. tripolyphosphate;c. a silica abrasive;d. a humectant selected from the group consisting of glycerin, sorbitol, polyethylene glycol, propylene glycol, and mixtures thereofe. from about 0.25% to about 12%, by weight of the composition, of cocamidopropyl betaine;f. from about 0.1% to about 15%, by weight of the composition, of a carboxyvinyl polymer; andg. up to 20%, by weight of the composition, of water.2. The single-phase dentifrice composition of claim 1 , wherein the composition comprises from about 0.25% to about 5% claim 1 , by weight of the compositions claim 1 , of titanium dioxide.3. The single-phase dentifrice composition of claim 1 , wherein the composition comprises from about 0.005% to about 5% claim 1 , by weight of the compositions claim 1 , of a sweetening agent.4. The single-phase dentifrice composition of claim 1 , wherein the composition comprises no added water.5. The single-phase dentifrice composition of comprising from about 1% to about 35% claim 1 , by weight of the composition claim 1 , of the tripolyphosphate.6. The single-phase dentifrice composition of comprising about 0.454% claim 1 , by weight of the composition claim 1 , of stannous fluoride.7. The single-phase dentifrice composition of claim 1 , wherein the composition has a pH of from about 4 to about 10.8. The single-phase dentifrice composition of claim 1 , wherein the composition comprises a peroxide source.9. The single-phase dentifrice composition of claim 8 , wherein the peroxide ...

LOW GLYCEMIC COMPOSITION AND METHODS OF MAKING AND USING THEREOF

An edible composition, comprising a low glycemic index sugar component having a glycemic index of not more than 20, wherein the edible composition comprises not less than 50% weight of the low glycemic index sugar component, wherein the edible composition is substantially free of D-sucrose, D-fructose, D-glucose, sugar alcohols, and non-sugar sweeteners, and wherein the edible composition have a sweetness taste profile substantially similar to D-sucrose. 1. An sweet composition , comprising a low glycemic index sugar component having a glycemic index of not more than 20 , wherein the sweet composition comprises not less than 50% weight of the low glycemic index sugar component , wherein the sweet composition is substantially free of D-sucrose , D-fructose , D-glucose , sugar alcohols , and non-sugar sweeteners.2. The sweet composition of claim 1 , wherein the low glycemic index sugar component has a glycemic index of not more than 15.3. The sweet composition of claim 1 , wherein the low glycemic index sugar component is not less than 90% weight of the sweet composition.4. The sweet composition of claim 1 , wherein the low glycemic index sugar component comprises a low glycemic index sugar having a glycemic index of not more than 15 and a molecular weight of not more than 540.5. The sweet composition of claim 1 , wherein the low glycemic index sugar component consists essentially of low glycemic index sugars claim 1 , wherein each low glycemic index sugar has a glycemic index of not more than 20 and a molecular weight of not more than 360.6. The sweet composition of claim 1 , wherein the low glycemic index sugar component comprises psicose claim 1 , sorbose claim 1 , tagatose claim 1 , trehalose claim 1 , isomaltulose claim 1 , raffinose or a combination thereof.7. The sweet composition of claim 1 , wherein the low GI sugar component consists essentially of psicose claim 1 , isomaltulose claim 1 , and trehalose.8. The sweet composition of claim 1 , wherein the low GI ...

Chewing Gum With Tomatidine

A chewing gum with a liquid-fill composition and a surrounding gum region, with one or both containing active ingredients, such as herbal, medicinal and/or mineral elements or combinations thereof, present in an amount of at least about 0.05 mg. 1. A chewing gum product consisting essentially of a first substance configured so as to have at least one cavity capable of retaining a liquid or semi-liquid substance as a second substance , wherein at least said first substance has an active ingredient consisting essentially of tomatidine and at least one ingredient selected from the group consisting of calcium , dexatrim , oatmeal fiber , a vitamin , a mineral supplement , a medicinal component , a lipid substance (HDL) , a mineral supplement , a chemotherapeutic agent , a diuretic , an antacid , an antibiotic , a herbal component , a stimulant , a metabolic enhancer , siberian ginseng , vitamin E , green tea , zinc , casgara sagrada mahuang , apple pectin , astragalus , dandelion , guarana , chickweek , bee pollen , gymnema sylvestre , chromium picolinate , licorice , bluegreen algae , bladderwrack , royal jelly , ginger , damiana , magnesium , lecithin , sarsaparilla , gotu kola , golden seal , nettles , chitosan , and combinations thereof , said active ingredient present in an amount of at least about 0.05 mg , wherein said second substance includes tomatidine and said at least one ingredient , said at least one ingredient in said first substance being the same as said at least one ingredient in said second substance.2. A chewing gum product consisting essentially of a first substance configured so as to have at least one cavity capable of retaining a liquid or semi-liquid substance as a second substance , wherein at least said first substance has an active ingredient consisting essentially of tomatidine and at least one ingredient selected from the group consisting of calcium , dexatrim , oatmeal fiber , a vitamin , a mineral supplement , a medicinal component , a ...

Chewing gums

The present invention relates to chewing gum containing a synergic combination of zinc and vegetable extracts containing polyphenols. Said chewing gum is useful in treating the symptoms of halitosis.

CANNABINOID AND SUGAR ALCOHOL COMPLEX, METHODS TO MAKE AND USE

The present invention generally relates to a sugar alcohol and cannabinoid complex, and methods to prepare this complex from cannabinoid oil comprising at least one cannabinoid. The complex is in solid form and may be used in food, pharmaceutical, cosmetic formulations, and medical devices wherein solid forms of cannabinoid are desirable. This complex also enhances release of active cannabinoids in oral consumption. Methods to make this complex are also disclosed. 1. A composition , comprising:a complex comprising at least one sugar alcohol selected from the group consisting of isomalt, mannitol, sorbitol, xylitol, lactitol, maltitol, and erythritol; and{'sup': '9', 'at least one cannabinoid selected from the group consisting of Δ-tetrahydrocannabinol, cannabidiol, cannabinol, and cannabigerol;'}wherein the at least one cannabinoid and the at least one sugar alcohol are present in the complex in a weight ratio based on dry weight of 1:5 to 1:30.2. The composition of claim 1 , wherein the at least one cannabinoid and the at least one sugar alcohol are present in the complex in a weight ratio based on dry weight of 1:5 to 1:10.3. The composition of claim 1 , further comprising at least one pharmaceutically acceptable carrier claim 1 , adjuvant claim 1 , or additive.4. The composition of claim 3 , wherein the composition is formulated for sublingual claim 3 , buccal claim 3 , dermal claim 3 , oral claim 3 , or rectal administration.5. The composition of claim 3 , wherein the composition is in the form of a tablet claim 3 , a capsule claim 3 , a chewing gum claim 3 , a lozenge claim 3 , a pill claim 3 , a pastille claim 3 , a patch claim 3 , a dissolvable strip claim 3 , a spray mist claim 3 , or a suppository tablet.6. The composition of claim 1 , further comprising at least one cosmetically acceptable bulking agent claim 1 , carrier claim 1 , or filler to form a cosmetic preparation.7. The composition of claim 6 , wherein the cosmetic preparation is in cream claim 6 , ...

CHEWING GUM CONTAINING VITAMIN C

Chewing gum containing vitamin C for use in the treatment of nausea in humans. 15-. (canceled)6. A Chewing gum containing vitamin C for use in the treatment of nausea in humans , characterized in that a piece of chewing gum contains vitamin C in amounts of 50 mg to 300 mg.7. The chewing gum according to claim 6 , for use in the treatment of nausea associated with early pregnancy.8. The chewing gum according to claim 6 , for use in the treatment of nausea associated with seasickness.9. The chewing gum according to claim 6 , characterized in that the chewing gum is coated.10. The chewing gum according to claim 7 , characterized in that the chewing gum is coated.11. The chewing gum according to claim 8 , characterized in that the chewing gum is coated.12. The chewing gun according to claim 6 , wherein the piece of chewing gum contains vitamin C in amounts of 100 mg to 250 mg.13. The chewing gun according to claim 12 , wherein the piece of chewing gum contains vitamin C in amounts of 150 mg to 200 mg. The present invention relates to a chewing gum containing vitamin C for use in the treatment of nausea in humans.Nausea in humans, for example when traveling by sea, on bus trips or car journeys in the back seat and when driving autonomously, on airplanes and in space travel, is sometimes due to a lack of vitamin C in the blood. The deficiency is associated with increased histamine levels, which in turn is associated with states of nausea. The administration of vitamin C has therefore been investigated and found to be effective for the treatment of nausea, for example in connection with seasickness (Impact of oral vitamin C on histamine levels and seasickness.; J Vestib Res. 2014; 24(4):281-8).At the same time, these studies have shown that the effect of administering vitamin C alone could not reliably prevent the occurrence of nausea in all test subjects. The present invention is therefore based on the object of improving the antiemetic effect of vitamin C by providing a ...

Cannabinoid chewing gum with improved release of cannabinoids

A chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum including water-soluble chewing gum ingredients mixed into water-insoluble gum base, wherein the chewing gum has one or more cannabinoids, and wherein the chewing gum generates saliva and delivers at least 10% by weight of the one or more cannabinoids to the oral mucosa during the first 5 minutes of chewing.

CANNABINOID CHEWING GUM WITH POLYVINYL ACETATE ELASTOMER PLASTICIZERS

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum including water-soluble chewing gum ingredients mixed into water-insoluble gum base, wherein the gum base has one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the one or more elastomer plasticizers includes one or more polyvinyl acetate elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum has one or more cannabinoids. 165-. (canceled)66. A chewing gum for mucosal delivery of cannabinoids , the chewing gum being formulated as an extruded chewing gum comprising water-soluble chewing gum ingredients mixed into water-insoluble gum base ,the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, one or more vinyl laurate-vinyl acetate copolymers in an amount of less than 10% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base,wherein the one or more elastomer plasticizers comprises one or more polyvinyl acetate elastomer plasticizers in an amount of 8-50% by weight of the gum base, andwherein the chewing gum comprises one or more cannabinoids.67. The chewing gum according to claim 66 , wherein the one or more cannabinoids is homogeneously distributed in the water-insoluble gum base comprising the one or more polyvinyl acetate elastomer plasticizers.68. The chewing gum according to claim 66 , wherein the one or more cannabinoids is embedded in the water-insoluble gum base comprising the one or more polyvinyl acetate elastomer plasticizers.69. The chewing gum according to claim 66 , wherein the release rate of the ...

CANNABINOID CHEWING GUM WITH SUGAR ALCOHOLS

The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum including water-soluble chewing gum ingredients and water-insoluble gum base, wherein the gum base has one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the water-soluble chewing gum ingredients include one or more sugar alcohols in an amount of 35-80% by weight of the chewing gum, and wherein the chewing gum has one or more cannabinoids. 179-. (canceled)80. A chewing gum for mucosal delivery of cannabinoids , the chewing gum comprising water-soluble chewing gum ingredients and water-insoluble gum base ,the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base,wherein the one or more elastomer plasticizers comprise one or more polyvinyl acetate elastomer plasticizers,wherein the water-soluble chewing gum ingredients comprise one or more sugar alcohols in an amount of 35-80% by weight of the chewing gum, andwherein the chewing gum comprises one or more cannabinoids.81. The chewing gum according to claim 80 , wherein the one or more sugar alcohols is present in an amount of 40-70% by weight of the chewing gum.82. The chewing gum according to claim 80 , wherein at least 10% by weight of the one or more cannabinoids is present in unbound form.83. The chewing gum according to claim 80 , wherein the one or more cannabinoids is embedded in the one or more sugar alcohols.84. The chewing gum according to claim 80 , wherein the one or more sugar alcohols and water-insoluble gum base are partly separated in the chewing gum.85. The chewing gum according to claim 80 , wherein the one or ...

Compositions Comprising Guaifenesin and Eriodictyol

The present invention refers to a composition comprising eriodictyol and guaifenesin. In particular, the present invention refers to a composition comprising eriodictyol and guaifenesin, said composition being for medical use, in particular for use in the prevention and treatment of respiratory diseases. Moreover, the present invention relates to the use of eriodictyol and guaifenesin for the preparation of a pharmaceutical composition. Finally, the present invention relates to the use of eriodictyol for masking or inhibiting the bitter taste of guaifenesin or guaifenesin comprising compositions. 1. A composition , comprising(a) guaifenesin or one or more of its derivatives or isomers or mixtures thereof, and(b) eriodictyol or one or more of its derivatives or isomers or mixtures thereof; and(c) optionally at least one pharmaceutically acceptable adjuvant or additive.2. The composition according to claim 1 , wherein the derivative of eriodictyol is selected from the group consisting of its salts claim 1 , esters and mixtures thereof and the derivative of guaifenesin is selected from the group consisting of its salts claim 1 , esters and mixtures thereof.3. The composition according to claim 1 , comprising guaifenesin in an amount in a range of 2000 to 20000 ppm.4. The composition according to claim 1 , comprising eriodictyol in an amount in a range of 4 to 400 ppm.5. The composition according to claim 1 , comprising component (a) and component (b) in a ratio (w/w) in a range of from 5:1 to 5000:1.6. The composition according to claim 1 , further comprising homoeriodictyol or a derivative or isomer thereof claim 1 , or a mixture thereof.7. The composition according to claim 1 , further comprising one or more pharmaceutically effective compounds claim 1 , optionally one or more chosen from analgesic agents claim 1 , anti-inflammatory agents claim 1 , antitussives claim 1 , decongestants claim 1 , and antihistamines.8. The composition according to claim 1 , wherein the ...

COMPOSITIONS AND METHODS FOR TREATING CROHN'S DISEASE AND RELATED CONDITIONS AND INFECTIONS

In alternative embodiments, the invention provides a “triple combination” therapy for treating, ameliorating and preventing Crohn's Disease (or Crohn syndrome, terminal or distal ileitis or regional enteritis) or related disorders and conditions in mammals, such as paratuberculosis in mammals, or Johne's disease, including genetically-predisposed and chronic disorders, where the microbial or bacterial flora of the bowel is at least one causative or symptom-producing factor; and compositions for practicing same. In alternative embodiments, methods and compositions of the invention comprise or comprise use of therapies, medications, formulations and pharmaceuticals comprising active agents that can suppress or eradicate the microbiota super-infection that causes Crohn's Disease or paratuberculosis infection in mammals. In alternative embodiments, the methods and uses of the invention for treating, ameliorating and preventing Crohn's Disease and complications of Crohn's Disease, or related disorders and conditions in mammals, such as paratuberculosis in mammals, or Johne's disease, comprises administration to an individual (human or mammal) in need thereof: (1) an anti-TNFα composition, or a composition capable of down-modulating TNFα activity; (2) a Hyperbaric Oxygen Treatment, or HBOT; and (3) an anti sub species paratuberculosis (MAP) (an anti-MAP) agent, composition or therapy. 1. A method for treating , ameliorating and/or preventing a Crohn's Disease , a complication of a Crohn's Disease , or a Crohn's Disease-related fistulae , comprising administering to an individual in need thereof a therapeutic combination comprising:(1) at least one anti-TNFα composition or drug; or, at least one composition or drug capable of down-modulating or down-regulating a TNFα activity; and{'i': 'Mycobacterium avium', '(2) at least two anti-sub species paratuberculosis (MAP) (an anti-MAP) agent.'}2. The method of claim 1 , wherein the at least one anti-TNFα composition or drug claim ...

METHOD FOR MANUFACTURING MULTICORE GELATIN MICROCAPSULE

Provided is a method for producing a multicore gelatin microcapsule containing a flavoring agent, the multicore gelatin microcapsule having a time to the flavor emanation peak ranging from 1 minute 30 seconds to less than 4 minutes in the case of use in a food. The method for producing a multicore gelatin microcapsule comprises the steps of: adding a transglutaminase to an oil-in-water emulsion composition containing gelatin and a flavoring agent to yield a mixed solution containing the gelatin in an amount of 10 to 25% by mass; and spraying the mixed solution and cooling and solidifying the sprayed solution. 1(a) adding a transglutaminase to an oil-in-water emulsion composition containing gelatin and a flavoring agent to yield a mixed solution containing the gelatin in an amount of 10 to 25% by mass; and(b) spraying the mixed solution and cooling and solidifying the sprayed solution.. A method for producing a multicore gelatin microcapsule, the method comprising the steps of: The present invention relates to a method for producing a multicore gelatin microcapsule.In the fields of foods and pharmaceutical products containing flavoring agents, sweeteners, vitamins, and other ingredients, multicore microcapsules have been used as a means, for example, for suppressing oxidation and deterioration of (for imparting stability to) the ingredient or for reducing the dissolution rate of the ingredient in the oral cavity or the like (for imparting controlled release properties). Such multicore microcapsules comprise a film-forming substance, which is typically exemplified by gelatin, agar, carrageenan, gellan gum, and pectin. In particular, a microcapsule comprising gelatin as the film-forming substance (hereinafter, also called multicore gelatin microcapsule) is excellent in oxygen barrier properties and thus is preferably used for example in the case where the ingredient must be prevented from oxidation.As the food preferences of consumers have diversified, there is an ...

Means and methods for preventing and/or treating caries

The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans , wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans . In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

ANTI-OBESITY COMPOSITION

An object of the present invention is to provide an obesity-suppressing composition that suppresses fat accumulation in adipocytes and that has an effect of suppressing body weight gain. 1. A method to suppress obesity , comprising administering to a subject in need thereof an effective amount of a composition comprising the following components (A) and (B):(A) at least one member selected from the group consisting of oleuropein and hydroxytyrosol; and(B) at least one member selected from the group consisting of a sulforaphane compound and willow extract.2. The method according to claim 1 , wherein the composition comprises at least oleuropein and component (B).3. The method according to claim 1 , wherein the composition comprises at least sulforaphane and component (A).4. The method according to claim 1 , wherein the composition comprises an olive extract comprising the oleuropein claim 1 , and component (B).5. The method according to claim 1 , wherein the composition is an oral composition.6. A method to suppress obesity claim 1 , comprising administering to a subject in need thereof an effective amount of a composition comprising the following components (A) and (B):(A) oleuropein; and(B) sulforaphane.7. The method according to claim 6 , wherein the composition comprises an olive extract comprising the (A) oleuropein claim 6 , and (B) sulforaphane. The present invention relates to an obesity-suppressing composition (anti-obesity composition). More specifically, the present invention relates to an obesity-suppressing composition suppressing fat accumulation and comprising oleuropein in combination with one or more members selected from willow extract and sulforaphane.Due to lifestyle factors, such as the spread of high-calorie foods and a reduction in daily physical activity, the number of people who develop diabetes or who are insulin resistant is increasing not only in middle-aged and elderly people, but also in young people. One of the main factors for this is ...

COMPOSITION FOR PREVENTING OR TREATING STROKE OR DEGENERATIVE BRAIN DISEASE

The present invention relates to a composition for preventing and/or treating a stroke or a degenerative brain disease comprising: at least two substances selected from the group consisting of egg yolk lecithin, glycerol, sodium oleate, medium chain triglyceride and refined fish oil; olive oil; and soybean oil. The composition of the present invention has an excellent neuroprotective effect but no toxicity or side effects, and thus can be effectively and safely used for preventing, treating or ameliorating a stroke or a degenerative brain disease. 112.-. (canceled)13. A method for preventing , ameliorating or treating stroke or degenerative brain disease in a subject , comprising administering to the subject an effective amount of composition comprising (a) at least two substances selected from a group consisting of egg yolk lecithin , glycerol , sodium oleate , medium chain triglyceride , and refined fish oil , (b) olive oil , and (c) soybean oil.14. The method of claim 13 , the composition comprises olive oil claim 13 , soybean oil claim 13 , medium chain triglyceride and refined fish oil.15. The method of claim 14 , the composition comprises 0.1-20 wt % of the olive oil claim 14 , 0.1-20 wt % of the soybean oil claim 14 , 0.1-20 wt % of the medium chain triglyceride claim 14 , and 0.1-10 wt % of the refined fish oil.16. The method of claim 13 , the composition comprises olive oil claim 13 , soybean oil claim 13 , egg yolk lecithin claim 13 , glycerol claim 13 , and sodium oleate.17. The method of claim 16 , the composition comprises 1.0-50 wt % of the olive oil claim 16 , 0.1-20 wt % of the soybean oil claim 16 , 0.01-5 wt % of the egg yolk lecithin claim 16 , 2.25 wt % of the glycerol and 0.01-1 wt % of the sodium oleate.18. The method of claim 13 , wherein the degenerative brain disease is selected from a group consisting of dementia claim 13 , Alzheimer's disease claim 13 , Parkinson's disease claim 13 , Huntington's chorea claim 13 , Pick's disease claim 13 , ...

Method of Naturally Decomposing Chewing Gum

A method naturally decomposing a piece of gum uses a quantity of biological organism infused through a quantity of chewing-gum base. Once the chewing-gum base is masticated by a user, the biological organisms come into contact with the user's saliva and begin to biodegrade the chewing-gum base. This method helps to prevent irresponsible disposal of the chewing-gum base after being removed from the user's mouth. 1. A method of naturally decomposing chewing gum , the method comprises the steps of:(A) providing a quantity of chewing-gum base and a quantity of biological organisms, wherein the quantity of biological organisms is infused throughout the quantity of chewing-gum base;(B) providing a quantity of saliva within an enclosing kneader;(C) masticating the quantity of salvia into the quantity of chewing-gum base by placing the quantity of chewing-gum base into the enclosing kneader;(D) executing a biodegradation process for the quantity of chewing-gum base with the quantity of biological organisms as the quantity of biological organisms is activated through contact with the quantity of saliva during step (C); and(E) accelerating the biodegradation process for the quantity of chewing-gum base, if the quantity of chewing-gum base is removed from the enclosing kneader.2. The method of naturally decomposing chewing gum claim 1 , the method as claimed in claim 1 , the quantity of biological organisms is a type of fungus.3. The method of naturally decomposing chewing gum claim 2 , the method as claimed in claim 2 , the type of fungus is aspergillus oryzae.4. The method of naturally decomposing chewing gum claim 1 , the method as claimed in claim 1 , the quantity of biological organisms is a type of bacteria.5. The method of naturally decomposing chewing gum claim 1 , the method as claimed in claim 1 , the quantity of chewing-gum base is made of a chicle base.6. The method of naturally decomposing chewing gum claim 1 , the method as claimed in claim 1 , the quantity of ...

Method for manufacturing medicated chewing gum without cooling

An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described. 1. A method for manufacturing chewing gum including at least one therapeutically active ingredient , comprising the steps of:placing one or more gum base(s) in a container with a sugar alcohol in an oven and heating said container until said gum base(s) melts to an internally measured temperature between 140-160 deg F.;mixing in a commercial mixer one or more active ingredient(s), sugar alcohol(s), and flavorings within a range of from 3 to 7 minutes;adding the melted gum base into the mixer and mixing within a range of from 2 to 6 minutes until a homogeneous mass is produced;conditioning said homogenous mass for at least 6 hours at a temperature not greater than 75 deg F. and 60% relative humidity;milling the dried mass into particulates at room temperature using a mesh screen of appropriate particle size ranging between 0.10 inch to 0.30 inch;mixing the particulates with lubricants in an orbital or planetary mixer within a range of from 2 to 4 minutes; andtableting the powder by a tablet press.2. ...

Method for manufacturing medicated chewing gum without cooling

An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described. 1. A method for manufacturing chewing gum including at least one therapeutically active ingredient , comprising the steps of:placing one or more gum base(s) in a container with a sugar alcohol in an oven and heating said container until said gum base(s) melts to an internally measured temperature between 140-160 deg F.;mixing in a commercial mixer one or more active ingredient(s), sugar alcohol(s), and flavorings within a range of from 3 to 7 minutes;adding the melted gum base into the mixer and mixing within a range of from 2 to 6 minutes until a homogeneous mass is produced;conditioning said homogenous mass for at least 6 hours at a temperature not greater than 75 deg F. and 60% relative humidity;milling the dried mass into particulates at room temperature using a mesh screen of appropriate particle size ranging between 0.10 inch to 0.30 inch;mixing the particulates with lubricants in an orbital or planetary mixer within a range of from 2 to 4 minutes; andtableting the powder by a tablet press.2. ...

Method Of Protecting Teeth Against Erosion

Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages. 1. A single-phase dentifrice composition comprising:a. stannous fluoride;b. from about 2% to about 30% tripolyphosphate, by weight of the composition;c. a silica abrasive;d. a humectant selected from the group consisting of glycerin, sorbitol, polyethylene glycol, propylene glycol, and mixtures thereof;e. from about 0.25% to about 5% of titanium dioxide, by weight of the composition;f. From about 0.005% to about 5% of saccharin, by weight of the composition;g. From about 0.25% to about 12% of cocamidopropyl betaine, by weight of the composition;h. From about 1% to about 6% of sodium lauryl sulfate, by weight of the composition; andi. up to 20% water, by weight of the composition; wherein the composition comprises no added water.2. The single phase dentifrice composition according to comprising about 0.454% stannous fluoride claim 1 , by weight of the composition.3. The single-phase dentifrice composition according to comprising from about 5% to about 25% of the tripolyphosphate claim 1 , by weight of the composition.4. The single-phase dentifrice composition according to having a pH of from about 4 to about 10.5. The single-phase dentifrice composition according to having a pH of from about 4.5 to about 8.6. The single-phase dentifrice composition according to comprising from about 10% to about 50% of the silica abrasive claim 3 , by weight of the composition.7. The single-phase dentifrice composition according to further comprising a peroxide source.8. The single-phase dentifrice composition according to wherein the peroxide source ...

TABLETED CANNABINOID CHEWING GUM WITH LAYERED STRUCTURE

The present invention relates to a tableted chewing gum composition for oral administration of cannabinoids, the composition comprising a plurality of particles, including a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients, and the composition constituting at least two layers, wherein a first layer of the composition comprises water-insoluble gum base and a second layer of the composition, which is cohered to and adjacent to the first layer, comprises water-soluble chewing gum ingredients, the second layer being free of water-insoluble gum base, and wherein the composition comprises one or more cannabinoids. 193-. (canceled)94. A tableted chewing gum composition for oral administration of cannabinoids , the composition comprising a plurality of particles , including a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients , and the composition constituting at least two layers , whereina) a first layer of the composition comprises water-insoluble gum base andb) a second layer of the composition, which is cohered to and adjacent to the first layer, comprises water-soluble chewing gum ingredients, the second layer being free of water-insoluble gum base, andwherein the composition comprises one or more cannabinoids.95. The tableted chewing gum composition according to claim 94 , wherein the composition consists of two layers where the first layer is cohered to and adjacent to the second layer.96. The tableted chewing gum composition according to claim 94 , wherein the weight ratio of the first layer relative to the second layer is from 1:10 to 10:1.97. The tableted chewing gum composition according to claim 94 , wherein the composition consists of three layers where the first layer is the middle layer claim 94 , and the second layer is cohered to and adjacent to one side of ...

NUTRACEUTICAL CONFECTIONARY COMPOSITION CONTAINING CAFFEINE AND L-THEANINE

In general, certain embodiments of the present disclosure provide compositions or mechanisms for oral administration of caffeine via a functional nutraceutical confectionary composition. According to various embodiments, a nutraceutical confectionary composition is provided with a ratio of caffeine to L-theanine ranging from about 1:1 to about 1:2. In some embodiments, the ratio of caffeine to L-theanine is about 2:3. In various embodiments, the nutraceutical confectionary composition may provide caffeine in a range from about 5 mg to about 100 mg per serving. L-theanine may be provided in a range from about 5 mg to about 200 mg per serving. In some embodiments, caffeine may comprise about 0.8% to 10% by weight of the composition; and L-theanine may comprise about 1.2% to 20% by weight of the composition. In certain embodiments, the nutraceutical confectionary composition may comprise a chewing gum. 1. A nutraceutical confectionary composition comprising caffeine and L-theanine in combination with a nutraceutically acceptable carrier , wherein the ratio of caffeine to L-theanine ranges from about 1:1 to about 1:2.2. The composition of claim 1 , wherein the ratio of caffeine to L-theanine ranges from about 3:5 to about 4:5.3. The composition of claim 1 , wherein the ratio of caffeine to L-theanine is about 2:3.4. The composition of claim 1 , wherein caffeine is provided in a range from about 5 mg to about 100 mg per serving and L-theanine is provided in a range from about 5 mg to about 200 mg per serving.5. The composition of claim 1 , comprising about 40 mg to about 60 mg of caffeine per serving and about 40 mg to about 120 mg of L-theanine per serving.6. The composition of claim 1 , wherein caffeine comprises about 0.8% to 10% by weight of the composition; and L-theanine comprises about 1.2% to 20% by weight of the composition.7. The composition of claim 1 , wherein the nutraceutical confectionary composition comprises a chewing gum.8. The composition of claim 7 , ...

Chewing Gum Comprising Nicotine

A nicotine chewing gum is disclosed, the nicotine chewing gum having gum base polymers, nicotine, and microcrystalline cellulose as a carrier for the nicotine, the gum base polymers include polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight of the gum base polymers, and the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer. Also, a method for producing a nicotine chewing gum is disclosed. 1. A nicotine chewing gum comprising gum base polymers , nicotine , and microcrystalline cellulose as a carrier for the nicotine ,the gum base polymers comprising polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight of the gum base polymers, andwherein the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer.2. The nicotine chewing gum according to claim 1 , wherein said nicotine is nicotine in its base form.3. The nicotine chewing gum according to claim 1 , wherein a total content of gum base ingredients selected from the group consisting of polyterpene resins claim 1 , resins based on gum rosin claim 1 , wood rosin and tall oil resin is less than 5 percent by weight of the nicotine chewing gum.4. The nicotine chewing gum according to claim 1 , wherein the nicotine chewing gum contains no polyterpene resins and no resins based on gum rosin claim 1 , wood rosin or tall oil resin.5. The nicotine chewing gum according to claim 1 , wherein the nicotine chewing gum comprises gum base polymers in an amount of between 15 and 80 percent by weight of the nicotine chewing gum.6. The nicotine chewing gum according to claim 1 , wherein said microcrystalline cellulose is provided in the form of particles having an average particle size between 10 and 250 micrometers.7. (canceled)8. The nicotine chewing gum according to claim 1 , wherein the nicotine ...

COMBINATION PRODUCT FOR PROPHYLAXIS AND TREATMENT OF IRRITABLE BOWEL SYNDROME

A combination product comprising a strain of NCIMB 41676 and a strain of NCIMB 41003 is used in the prophylaxis or treatment of irritable bowel syndrome (IBS). The combination product leads to a surprising, sustained positive effects, even after feeding has stopped.

Method Of Protecting Teeth Against Erosion

Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages. 1. A single-phase dentifrice composition comprising:a. a metal ion source selected from the group consisting of stannous salts, zinc salts, and combinations thereof.b. tripolyphosphate;c. a silica abrasive;d. a humectant selected from the group consisting of glycerin, sorbitol, polyethylene glycol, propylene glycol, and mixtures thereof;e. from about 0.25% to about 12%, by weight of the composition, of cocamidopropyl betaine;f. from about 0.1% to about 15%, by weight of the composition, of a thickening system selected from the group consisting of carrageenan, hydroxyethyl cellulose, sodium carboxymethylcellulose, sodium hydroxyethyl cellulose, gum karaya, xanthan gum, gum arabic, gum tragacanth, and combinations thereof; andg. from 10% to 50%, by weight of the composition, of water.2. The single-phase dentifrice composition of claim 1 , wherein the metal ion source comprises stannous fluoride.3. The single-phase dentifrice composition of claim 1 , wherein the composition comprises from about 0.005% to about 5% claim 1 , by weight of the compositions claim 1 , of a sweetening agent.4. The single-phase dentifrice composition of claim 2 , wherein the humectant comprises glycerin.5. The single-phase dentifrice composition of comprising from about 1% to about 35% claim 1 , by weight of the composition claim 1 , of the tripolyphosphate.6. The single-phase dentifrice composition of claim 2 , comprising about 0.454% claim 2 , by weight of the composition claim 2 , of stannous fluoride.7. The single-phase dentifrice composition of claim 1 , wherein ...

SEXUAL FUNCTION IMPROVING COMPOSITION CONTAINING AS ACTIVE INGREDIENT EXOPOLYSACCHARIDE PRODUCED BY MEANS OF CERIPORIA LACERATA

The present invention relates to a sexual function improving composition containing as an active ingredient: exopolysaccharide produced by means of ; a mycelium culture medium comprising the exopolysaccharide; dry powder of the mycelium culture medium; or an extract of the mycelium culture medium. The composition can be used as a sexual function improving drug for preventing or treating erectile dysfunction or diabetic erectile dysfunction or as a functional health food having sexual function improving effect. 1Ceriporia lacerataCeriporia lacerata. A composition for improving sexual function comprising an extracellular polysaccharide produced by ; a mycelial culture medium of containing the extracellular polysaccharide; dried powders of the mycelial culture medium; or an extract of the mycelial culture medium , as an effective ingredient.2. The composition of claim 1 , wherein the extracellular polysaccharide comprises 40 to 60 wt % of sugar and 30 to 40 wt % of protein claim 1 , and has a molecular weight of 100 to 150 kDa.3. The composition of claim 2 , wherein the extracellular polysaccharide comprises 43 to 47 wt % of sugar and 33 to 36 wt % of protein claim 2 , and has a molecular weight of 115 to 125 kDa.4. The composition of claim 2 , wherein the sugar contains mannose claim 2 , galactose and glucose.5. The composition of claim 1 , wherein the extracellular polysaccharide is prepared by the preparation method comprising the steps of:{'i': Ceriporia lacerata', 'Ceriporia lacerata,, '(a) culturing the mycelia of in a liquid to prepare a mycelial culture medium of'}{'i': 'Ceriporia lacerata', '(b) drying the mycelial culture medium of to form powders, and'}{'i': 'Ceriporia lacerata', '(c) extracting the powders of the mycelial culture medium of with a solvent, and filtering and concentrating the resultant extract under reduced pressure.'}6. The composition of claim 5 , wherein the medium for culturing in a liquid comprises sugar claim 5 , glucose claim 5 , ...

Method of Ameliorating Clotting Pathologies and Related Materials and Methods

Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies. 1. A method of reducing blood clotting in a stroke survivor subject in need thereof , comprising:administering a pharmaceutically-effective formulation of a tocotrienol-containing composition, and,administering pharmaceutically-effective formulation of clopigrel, and optionally,administering pharmaceutically-effective formulation of aspirin,sufficient to reduce risk of a further stroke in the subject.2. The method of claim 1 , wherein the tocotrienol-containing composition comprises: d-alpha-tocotrienol claim 1 , d-gamma-tocotrienol claim 1 , and d-delta-tocotrienol.3. The method of claim 1 , wherein the tocotrienol-containing composition comprises: d-alpha-tocotrienol claim 1 , d-gamma-tocotrienol claim 1 , d-delta-tocotrienol claim 1 , and d-alpha-tocopherol.4. The method of claim 1 , wherein the tocotrienol-containing composition comprises: d-alpha-tocotrienol 61.52 mg claim 1 , d-gamma-tocotrienol 112.80 mg claim 1 , d-delta-tocotrienol 25.68 mg claim 1 , d-alpha-tocopherol 91.60 IU claim 1 , plant squalene 51.28 mg claim 1 , phytosterol complex 20.48 mg claim 1 , and phytocarotenoid complex 360.00 ug.5. A method of claim 1 , which comprises administering up to 400 mg of the tocotrienol-containing composition for at least 30 days claim 1 , and a pharmaceutically-effective dose of the tocotrienol-containing composition weekly thereafter.6. The method of claim 1 , wherein the formulation comprises a dose of the tocotrienol-containing composition selected from the group consisting of: approximately 200 mg to approximately 1000 mg in one weekly dose; approximately 300 mg to approximately 1000 mg in one weekly dose; approximately 400 mg to approximately 500 mg in one weekly dose.7. The method of claim 1 , wherein the tocotrienol- ...

ORAL COMPOSITION AND CONFECTION

There are provided an oral composition and a confection that exhibit activity equivalent to or higher than that of a decanoic acid-containing composition, and a method for producing such an oral composition. The oral composition and the confection contain at least three ingredients: cinnamon, low molecular proanthocyanidin, and menthol. The method for producing, the oral composition includes the steps of: dissolving at least 0.2 to 1.0% by weight of low molecular proanthocyanidin in 0.2 to 2.0% by weight of at least one water-soluble solvent selected from glycerin or propylene glycol to form a solution; kneading at least 0.1 to 0.5% by weight of cinnamon and 0.1 to 0.4% by weight of menthol into sugar-free base dough to prepare candy- or gel-like kneaded dough; and mixing the solution with the kneaded dough. 1. An oral composition comprising at least three ingredients: cinnamon; low molecular proanthocyanidin; and menthol.2. The oral composition according to claim 1 , further comprising: at least one ingredient selected from a middle chain fatty acid claim 1 , a middle chain fatty acid ester claim 1 , and citral claim 1 ,3. The oral composition according to claim 1 , further comprising: a thickener.4. The oral composition according to claim 1 , wherein the cinnamon is a composition containing cinnamaldehyde.5. The oral composition according to claim 1 , further comprising at least one ingredient selected from decanoic acid or ethyl decanoate as a middle chain fatty acid or a middle chain fatty acid ester.6. The oral composition according to claim 1 , wherein the low molecular proanthocyanidin comprises Oligonol (trademark).7. The oral composition according to claim 1 , which contains at least 0.28 mg or more of cinnamon claim 1 , 0.5 mg or more of low molecular proanthocyanidin claim 1 , and 0.2 mg or more of menthol per oral dosage unit.8. The oral composition according to claim 2 , which contains at least one selected from 0.008 mg or more of a middle chain fatty ...

MILK FAT GLOBULE EPIDERMAL GROWTH FACTOR 8 REGULATES FATTY ACID UPTAKE

Methods and compositions for regulating fatty acid uptake and/or decreasing gastric motility in an animal are provided. 1. A method of increasing fatty acid uptake and/or decreasing gastric motility in an animal , the method comprising ,administering a polypeptide comprising (i) Milk Fat Globule Epidermal Growth Factor 8 (Mfge8), or (ii) an integrin-binding portion of Mfge8, to an animal in an amount sufficient to increase fatty acid uptake and/or to decrease gastric motility in the animal.2. The method of claim 1 , wherein the Mfge8 is human Mfge8 (SEQ ID NO:1) or is at least 80% identical to (i) SEQ ID NO:1 or (ii) an integrin-binding portion of SEQ ID NO:1.3. The method of claim 1 , wherein the animal is human4. The method of claim 3 , wherein the animal is under two or one years or under six claim 3 , five claim 3 , four claim 3 , three claim 3 , two claim 3 , or one months old.5. The method of claim 1 , wherein the animal is a premature human infant.6. The method of claim 1 , wherein the animal is diabetic or has cystic fibrosis.7. The method of claim 1 , wherein the polypeptide is administered intravenously claim 1 , subcutaneously claim 1 , intramuscularly claim 1 , rectally claim 1 , or orally.8. The method of claim 7 , wherein the polypeptide is administered as a component of a composition selected from the group consisting of a powder claim 7 , a tablet claim 7 , a capsule claim 7 , a lozenge claim 7 , a chewing gum claim 7 , a food product claim 7 , a supplemented beverage claim 7 , or a medical food.9. The method of claim 8 , wherein the food product is infant formula.10. A composition comprising a polypeptide comprising (i) Milk Fat Globule Epidermal Growth Factor 8 (Mfge8) claim 8 , or (ii) an integrin-binding portion of Mfge8.11. The composition of claim 10 , wherein the Mfge8 is human Mfge8 (SEQ ID NO:1) or is at least 80% identical to (i) SEQ ID NO:1 or (ii) an integrin-binding portion of SEQ ID NO:1.12. The composition of claim 10 , wherein the ...

NUTRICEUTICAL GELS

A nutraceutical food product includes a solid matrix and a liquid combined into a gel. The nutraceutical food product may include an immune modulator, such as transfer factor and/or a nanofraction immune modulator. A fruit component may be included in the nutraceutical food product. The fruit component may include at least one oligoproanthocyanidin-containing fruit, such as açai. 1. A composition , comprising:a gel, an oligomeric proanthocyanidin from acai dispersed throughout the gel, and a transfer factor dispersed throughout the gel and/or the oligomeric proanthocyanidin.2. The composition of claim 1 , wherein the gel comprises xanthan and guar gum.3. The composition of claim 1 , wherein the gel comprises xanthan claim 1 , guar gum and pectin.4. The composition of claim 3 , wherein the pectin comprises fruit pectin.5. The composition of claim 1 , wherein the composition further comprises at least one of an additional oligomeric proanthocyanidin-containing fruit juice or an oligomeric proanthocyanidin-containing fruit extract.6. The composition of claim 5 , wherein the additional oligomeric proanthocyanidin-containing fruit juice or the oligomeric proanthocyanidin-containing fruit extract is derived from at least one of elderberry claim 5 , grape or pomegranate.7. The composition of claim 1 , further comprising a surfactant.8. The composition of claim 7 , wherein the surfactant comprises glycerol monolaurate.9. The composition of claim 1 , further comprising a preservative.10. The composition of claim 9 , wherein the preservative is selected from the group consisting of sodium benzoate and paraben.11. The composition of claim 1 , wherein the transfer factor includes avian transfer factor and/or bovine transfer factor.12. The composition of claim 11 , wherein the transfer factor comprises avian transfer factor obtained from avian egg.13. The composition of claim 1 , wherein the composition is sterile.14. The composition of claim 1 , wherein the gel comprises a ...

COLOR INDICATING FORMULATIONS

Color indicating chewing gum compositions comprising one or more color compounds are provided. The compositions demonstrate a visual color or shade change from start of chewing to the end of chewing and provide oral health benefits. Methods of producing a color changing chewing gum are also provided. 1. A chewing gum composition comprising at least one water soluble color compound and optionally at least one water insoluble color compound; wherein the at least one water soluble compound leaches out of the chewing gum after from about 5 minutes to about 20 minutes of chewing.2. The chewing gum composition of claim 1 , wherein the at least one water soluble color compound is selected from the group consisting of any water soluble dye claim 1 , FD&C Blue 1 dye claim 1 , FD&C Blue 2 dye claim 1 , liquid caramel (regular or low 4 MEI) claim 1 , FD&C Red 40 claim 1 , FD&C Red 3 claim 1 , FD&C Yellow 5 claim 1 , FD&C Yellow 6 claim 1 , FD&C Green 3 claim 1 , fruit and vegetable based colorants (anthocyanins claim 1 , betanin) claim 1 , spirulina claim 1 , gardenia claim 1 , and combinations thereof.3. The chewing gum composition of claim 1 , wherein the at least one water insoluble color compound is selected from the group consisting of any pigment claim 1 , lake pigment claim 1 , titanium dioxide claim 1 , curcumin claim 1 , iron oxides claim 1 , FD&C Blue 1 lake claim 1 , any FD&C food grade lake or oil soluble dye claim 1 , beta carotene claim 1 , other carotenoids claim 1 , Beta Apo 8′ Carotenal claim 1 , canthaxanthin claim 1 , chlorophylls claim 1 , and combinations thereof.4. The chewing gum composition of claim 1 , further comprising an active ingredient.5. The chewing gum composition of claim 4 , wherein the active ingredient is a dental active agent.6. The chewing gum composition of claim 5 , wherein the dental active agent is selected from the group consisting of sodium tripolyphosphate claim 5 , sodium pyrophosphate (SPP) claim 5 , sodium hexametaphosphate ...

Tableted Cannabinoid Chewing Gum With Layered Structure

A tableted chewing gum composition for oral administration of cannabinoids includes a plurality of particles, including a first population of particles having water-insoluble gum base and a second population of particles having water-soluble chewing gum ingredients. The composition constitutes at least two layers, where a first layer of the composition has water-insoluble gum base and a second layer of the composition, which is cohered to and adjacent to the first layer, has water-soluble chewing gum ingredients. The second layer is free of water-insoluble gum base, and the composition includes one or more cannabinoids. 1. A tableted chewing gum composition , the composition comprising a plurality of particles , including a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients , and the composition constituting at least two layers , whereina) a first layer of the composition comprises water-insoluble gum base andb) a second layer of the composition, which is cohered to and adjacent to the first layer, comprises water-soluble chewing gum ingredients, the second layer being free of water-insoluble gum base, andwherein the composition comprises one or more cannabinoids.2. The tableted chewing gum composition according to claim 1 , wherein the composition consists of two layers.3. The tableted chewing gum composition according to claim 1 , wherein the weight ratio of the first layer relative to the second layer is from 1:10 to 10:1.4. The tableted chewing gum composition according to claim 1 , wherein the weight ratio of the first layer relative to the second layer is from 1:2 to 2:1.5. The tableted chewing gum composition according to claim 1 , wherein the composition consists of three layers where the first layer is the middle layer claim 1 , and the second layer is cohered to and adjacent to one side of the first layer claim 1 , and a third layer is cohered to and ...

Stimulation of saliva generation

The present invention is directed to products that promote saliva generation in the mouth through the use of various food grade acceptable acids. The products that enhance saliva production are preferably foods that are consumed in the mouth over a period of time of a minute or longer such as chewing gums, breath films, toothpaste and lozenges.

Method of protecting teeth against erosion

Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages.

Method of protecting teeth against erosion

Disclosed are methods of treating and protecting teeth against erosion by use of oral compositions comprising polymeric mineral surface active agents, metal ions such as stannous and zinc and combinations thereof. The present methods provide improved resistance of teeth to erosive demineralization or dissolution and prevention of tooth damage by subsequent exposure of teeth to erosive chemicals such as acidic foods and beverages.

NEW FORMULATION OF LACTOBACILLUS STRAINS FOR THE TREATMENT AND PREVENTION OF HELICOBACTER PYLORI COLONISATION IN THE UPPER AIRWAYS AND THE DIGESTIVE SYSTEM

The invention relates to new compositions for the treatment and prevention of colonisation of the oral cavity, the upper airways, the oesophagus, and the digestive system, wherein the formulation is preferably composed in the form of a chewing gum. 1LactobacillusH. pylori. A composition comprising a physiologically effective dose of cells in the form of a) a chewing gum , b) another preparation with prolonged residence time in the mouth , or c) a preparation with application in the upper airways , for the treatment of colonisation of the upper airways , the oesophagus , and/or the digestive system.2LactobacillusLactobacillus crispatus, Lactobacillus gasseri, Lactobacillus lactis, Lactobacillus helveticus, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus casei, Lactobacillus paracasei, Lactobacillus pentosus, Lactobacillus rhamnosus and Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus brevis, Lactobacillus fermentum, Lactobacillus viridescensBifidobacterium bifidum.. The composition according to claim 1 , wherein the cells are selected from the group and/or3Lactobacillus. The composition according to claim 1 , comprising an effective dose of cells per application between 10and 10cells in living claim 1 , viable claim 1 , dead claim 1 , or fragmented forms as cell wall constituents or isolated cell wall molecules respectively from 1×10to 1×10cells per application.4Lactobacillus. The composition according to claim 3 , comprising an effective dose of cells per application between 10and 10cells in living claim 3 , viable claim 3 , dead claim 3 , or fragmented forms as cell wall constituents or isolated cell wall molecules respectively from 10to 10cells per application.5Lactobacillus reuteriH. pylori. The composition according to claim 1 , comprising as filed under DSM 17648 in the form of a chewing gum for the treatment of colonisation of the oral cavity claim 1 , the upper airways claim 1 , the oesophagus claim 1 ...

Chewing gum making method

Composition with color indication

FIELD: food industry.SUBSTANCE: disclosed chewing gum composition contains at least one water-soluble coloring compound and at least one water-insoluble coloring compound. At least one water-soluble coloring compound is released from the chewing gum after chewing for 5 minutes to 20 minutes. At least one water-soluble coloring compound is selected from a group consisting of FD&C blue dye 1, FD&C blue dye 2, liquid caramel coloring agent (standard or low content of 4-MEI), FD&C red 40, FD&C red 3, FD&C yellow 5, FD&C yellow 6, FD&C green 3 and their combinations. At least one water-insoluble coloring compound is selected from a group consisting of a color pigment, titanium dioxide, curcumin, iron oxide, colorful varnish FD&C blue 1, any food paint varnish FD&C or oil-soluble dye, beta-carotene, other carotenoids, beta-apo-8'-carotene, canthaxanthin, chlorophylls and combinations thereof. Also disclosed is a method of producing a color-changing chewing gum.EFFECT: invention is aimed at chewing gum, changing color after chewing during 5–20 minutes, and to inform consumer on possibility of end of chewing process or end of release of dental active substance.12 cl, 6 dwg, 1 tbl, 3 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 728 204 C2 (51) МПК A23G 4/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A23G 4/00 (2020.02) (21)(22) Заявка: 2018125248, 12.12.2016 (24) Дата начала отсчета срока действия патента: Дата регистрации: (73) Патентообладатель(и): ВМ. РИГЛИ ДЖР. КОМПАНИ (US) 28.07.2020 11.12.2015 US 62/266,503 (43) Дата публикации заявки: 13.01.2020 Бюл. № 2 (45) Опубликовано: 28.07.2020 Бюл. № 22 (56) Список документов, цитированных в отчете о поиске: WO 2007076857 A1, 12.07.2007. WO 2001014875 A1, 01.03.2001. JP 2000083593 A, 28.03.2000. WO 2013061583 A1, 02.05.2013. WO 2002087352 A1, 07.11.2002. RU 2141217 C1, 20.11.1999. (85) Дата начала рассмотрения заявки PCT на ...

Sweet containing algae for the prevention of oro-dental infections

본 발명은 일반적으로 사탕류에 관한 것이다. 보다 구체적으로, 본 발명은 치아 상에 유익한 효과를 제공하는 사탕류에 관한 것이다. 본 발명에 따른 사탕류는 양호한 구강-치아 위생을 증진하고, 보다 특히 구강-치아 케어를 제공하며, 건강한 치아 및 치육을 증진하고 지속시킨다. 이는 미세조류 및/또는 미세조류의 추출물, 보다 특히 클로렐라 및/또는 클로렐라 의 추출물을 함유하는 것을 특징으로 한다. 마지막으로, 본 발명은 또한 양호한 구강-치아 건강을 증진하고 지속시키기 위하여 클로렐라 를 함유하는 사탕류, 바람직하게 무설탕 사탕류의 용도에 관한 것이다. The present invention relates generally to candy. More particularly, the present invention relates to candy flies that provide beneficial effects on the teeth. The candy according to the present invention promotes good oral-dental hygiene, more particularly provides oral-to-tooth care, and promotes and sustains healthy teeth and dentistry. It is characterized by containing extracts of microalgae and / or microalgae, more particularly chlorella and / or chlorella . Finally, the present invention also relates to the use of candy, preferably sugar-free candy, containing chlorella to promote and maintain good oral-dental health.

Oral compositions for providing optimum surface conditioning

FIELD: medicine. SUBSTANCE: method involves performing surface conditioning comprising improved hydrophilic properties of oral cavity surface associated with lowered contact angles with water or with increased anion surface charge and surface charge density; reduced dental deposit thickness. The result is achieved by applying oral composition containing surfactant polymer agent. EFFECT: enhanced effectiveness of treatment; provided smooth and clean dental surface feeling within long time period. 8 cl 8538 9$ сс ПЧ сэ (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВИ “” 2 236 838. (51) МПК? 13) С2 А 61К 7/16, 7/18 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 2002115621/15, 10.11.2000 (24) Дата начала действия патента: 10.11.2000 (30) Приоритет: 12.11.1999 1$ 60/165,351 (43) Дата публикации заявки: 10.01.2004 (45) Дата публикации: 27.09.2004 (56) Ссылки: ЗИ 774554 А, 30.10.1980. ЗИ 1828750 АЛ, 23.07.1993. КО 2085184 СЛ, 27.07.1997. КИ 2092162 С, 10.10.1997. МО 98122080 А, 28.05.1998. \МО 98/43603 А, 08.10.1998. (85) Дата перевода заявки РСТ на национальную фазу: 13.06.2002 (86) Заявка РСТ: 1$ 00/30808 (10.11.2000) (87) Публикация РСТ: М/О 01/34107 (17.05.2001) (98) Адрес для переписки: 129010, Москва, ул. Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. Е.Е .Назиной (72) Изобретатель: УАЙТ Дональд Джеймс Мл. (ЦЗ), ГЛЭНДОРФ Уилльям Майкл (4$), БУСШЕР Хенк Дж. (МЕ), НАЙТ Джаннин Р. (4$), БЭЙГ Ариф А. (4$) (73) Патентообладатель: ДЗЕ ПРОКТЕР ЭНД ГЭМБЛ КОМПАНИ (1$) (74) Патентный поверенный: Назина Елена Евгеньевна (54) ОРАЛЬНЫЕ КОМПОЗИЦИИ, ОБЕСПЕЧИВАЮЩИЕ ОПТИМАЛЬНОЕ КОНДИЦИОНИРОВАНИЕ ПОВЕРХНОСТИ (57) Изобретение относится к медицине и относится к оральной — композиции, содержащей полимерный поверхностно-активный агент для обеспечивания эффекта кондиционирования поверхности зубов и/или слизистых полости рта субъекта. Эффект — поверхностного кондиционирования включают (а) повышенный гидрофильный характер ...

Biodegradable chewing gum comprising at least one high molecular weight biodegradable polymer

The invention relates to a chewing gum comprising at least one biodegradable polymer, wherein the molecular weight of said polymer is at least 105000 g/mol (Mn). According to the invention, it has moreover been realized that this problem may be effectively dealt with by increasing the molecular weight of at least one of the biodegradable polymers in the chewing gum when compared to conventional chewing gum polymers and thereby increasing the robustness of the chewing gum with respect to softeners, emulsifiers and e.g. flavor.

Biodegradable chewing gum comprising at least one high molecular weight biodegradable polymer

The invention relates to a chewing gum comprising at least one biodegradable polymer, wherein the molecular weight of said polymer is at least 105000 g/mol (Mn). According to the invention, it has moreover been realized that this problem may be effectively dealt with by increasing the molecular weight of at least one of the biodegradable polymers in the chewing gum when compared to conventional chewing gum polymers and thereby increasing the robustness of the chewing gum with respect to softeners, emulsifiers and e.g. flavor.

口腔护理套件和组合物

口腔护理组合物包括分子量为约300至约3000的聚丁烯和口腔护理活性物质。口腔护理组合物还包括口腔护理载体。本发明也公开了包括聚丁烯、容器和使用说明书或将组合物直接涂敷到牙齿表面的涂药器的套件。所述套件的聚丁烯组分还可包括口腔护理活性物质或口腔护理载体。

New lactic acid bacteria and application thereof

FIELD: biology. SUBSTANCE: group of inventions relates to the Bifidobacterium longum IM55 KCCM11961P strain and to use thereof. Proposed is a Bifidobacterium longum IM55 KCCM11961P strain inducingly active towards the IL-10 expression. A live cell of the Bifidobacterium longum IM55 KCCM11961P strain, a non-living cell of the Bifidobacterium longum IM55 KCCM11961P strain or a product of cultivation of the Bifidobacterium longum IM55 KCCM11961P strain, wherein the product of cultivation includes the described strain, can be used in a pharmaceutical and food composition. Also proposed is a method of prevention or treatment of allergic diseases caused by a type 1 hypersensitivity reaction comprising a stage of administering Bifidobacterium longum IM55 KCCM11961P to an individual. EFFECT: due to an immunoregulatory effect and an inflammatory reaction inhibiting effect said strain can be effectively applied in prevention or treatment of allergic diseases caused by a type 1 hypersensitivity reaction, inflammatory diseases, immunopathological diseases, and in obtaining a medicinal product for prevention or treatment of allergic diseases caused by a type 1 hypersensitivity reaction. 18 cl, 30 dwg, 19 tbl, 11 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 752 157 C2 (51) МПК C12N 1/20 (2006.01) A61K 35/745 (2015.01) A61K 35/747 (2015.01) A61P 37/08 (2006.01) A23L 33/135 (2016.01) C12R 1/25 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C12N 1/20 (2021.02); A61K 35/745 (2021.02); A61K 35/747 (2021.02); A61P 37/08 (2021.02); A23L 33/135 (2021.02); C12R 1/25 (2021.02) (21)(22) Заявка: 2019127021, 31.01.2018 31.01.2018 23.07.2021 Приоритет(ы): (30) Конвенционный приоритет: 31.01.2017 KR 10-2017-0013632 (43) Дата публикации заявки: 02.03.2021 Бюл. № 7 (45) Опубликовано: 23.07.2021 Бюл. № 21 (86) Заявка PCT: KR 2018/001359 (31.01.2018) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 02.09.2019 (56) ...

Oral care kits and compositions

An oral care composition comprises polybutene with a molecular weight of about 300 to about 3000 and an oral care active. The oral care composition may further comprise an oral care carrier. Kits comprising polybutene, a container and instructions for use or an applicator for applying the composition directly to the tooth surfaces are also disclosed. The polybutene component of the kits can further comprise an oral care active or an oral care carrier.

Chewing gum

Настоящее изобретение относится к жевательной резинке, содержащей синергическую комбинацию цинка и растительных экстрактов, содержащих полифенолы. Предложенная жевательная резинка состоит из по меньшей мере из первой области с гуммиосновой и по меньшей мере из второй полностью водорастворимой области без гуммиосновы. Указанная жевательная резинка отличается присутствием синергической комбинации из эффективного количества растительных экстрактов и эффективного количества ионов цинка, по меньшей мере частично содержащихся в полностью растворимых в воде микрогранулах. Причем растительные экстракты выбирают из экстракта коры магнолии, экстракта зеленого чая и их комбинаций. А содержание ионов цинка находится в диапазоне от 0,0005% до 0,05% по массе, содержание растительного экстракта находится в диапазоне от 0,02% до 2%. Указанная жевательная резинка полезна в лечении симптомов галитоза. 19 з.п. ф-лы, 4 табл., 3 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 647 854 C2 (51) МПК A23G 4/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A23G 4/06 (2006.01) (21)(22) Заявка: 2015113334, 14.10.2013 (24) Дата начала отсчета срока действия патента: Дата регистрации: (73) Патентообладатель(и): Перфетти Ван Мелле С.п.А. (IT) 21.03.2018 (56) Список документов, цитированных в отчете о поиске: WO 2006079343 A1, 03.08.2006. WO 15.10.2012 IT MI2012A001734 (43) Дата публикации заявки: 10.12.2016 Бюл. № 34 2007067340 A1, 14.06.2007. CN 102204874 A, 05.10.2011. RU 2340326 C2, 10.12.2008. (45) Опубликовано: 21.03.2018 Бюл. № 9 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 15.05.2015 2 6 4 7 8 5 4 Приоритет(ы): (30) Конвенционный приоритет: R U 14.10.2013 (72) Автор(ы): КОЛЛЕ Роберто (IT), САРРИКА Андреа (IT), ДЕЛЕО Маурицио (IT) IB 2013/059341 (14.10.2013) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: R U 2 6 4 7 8 5 4 WO 2014/060929 (24.04.2014) Адрес для переписки: 191036, Санкт-Петербург, а/я 24, " ...

Patent RU2019127021A3

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2019 127 021 A (51) МПК C12N 1/20 (2006.01) A61K 35/745 (2015.01) A61K 35/747 (2015.01) A61P 37/08 (2006.01) A23L 33/135 (2016.01) C12R 1/25 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2019127021, 31.01.2018 (71) Заявитель(и): ЮНИВЕРСИТИ-ИНДАСТРИ КООПЕРЕЙШН ГРУП ОФ КЮН ХЕЕ ЮНИВЕРСИТИ (KR), НАВИФАРМ КО, ЛТД (KR) Приоритет(ы): (30) Конвенционный приоритет: 31.01.2017 KR 10-2017-0013632 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 02.09.2019 (72) Автор(ы): КИМ, Тон-Хюн (KR), ХАН, Мюн Чо (KR) R U (43) Дата публикации заявки: 02.03.2021 Бюл. № 7 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2018/143678 (09.08.2018) A Адрес для переписки: 123242, Москва, Кудринская пл., 1, а/я 35, "Михайлюк, Сороколат и партнеры-патентные поверенные" R U (57) Формула изобретения 1. Bifidobacterium longum IM55 KCCM11961P. 2. Lactobacillus plantarum IM76 KCCM11962P. 3. Bifidobacterium longum IM55 KCCM11961P по п. 1, где указанный Bifidobacterium longum IM55 KCCM11961P содержит последовательность 16S rDNA под SEQ ID NO: 1. 4. Bifidobacterium longum IM55 KCCM11961P по п. 1, где указанный Bifidobacterium longum IM55 KCCM11961P в качестве источника углерода использует D-глюкозу, Dманнит, D-лактозу, D-сахарозу, D-мальтозу, салицин, D-ксилозу, L-арабинозу, цитрат железа с эскулином, D-рафинозу и D-сорбит. 5. Lactobacillus plantarum IM76 KCCM11962P по п. 2, где указанный Lactobacillus plantarum IM76 KCCM11962P содержит последовательность 16S rDNA под SEQ ID NO: 2. 6. Lactobacillus plantarum IM76 KCCM11962P по п. 2, где указанный Lactobacillus plantarum IM76 KCCM11962P в качестве источника углерода использует L-арабинозу, D-рибозу, D-галактозу, D-глюкозу, D-фруктозу, D-маннозу, маннит, сорбит, Nацетилглюкозамин, амигдалин, арбутин, эскулин, салицин, целлобиозу, мальтозу, лактозу, мелибиозу, сахарозу, трегалозу, рафинозу, гентиобиозу, D-туранозу и глюконат. 7. Фармацевтическая ...

Method for protecting teeth against erosion

FIELD: medicine. SUBSTANCE: method involves applying oral compositions containing surfactants, metal ions like tin and zinc and their combinations. EFFECT: provided high teeth resistance to erosive demineralization or decay; prevented teeth injury. 8 c1, 4 tbl ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 311 901 (13) C2 (51) ÌÏÊ A61K A61K A61K A61K A61K ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ A61K ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ,A61K ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ A61K A61K A61Q (12) 8/73 8/69 8/64 8/44 8/19 8/42 8/36 8/24 8/21 11/00 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2005118406/15, 20.12.2002 (30) Êîíâåíöèîííûé ïðèîðèòåò: 13.12.2002 US 10/319,108 (73) Ïàòåíòîîáëàäàòåëü(è): ÄÇÅ ÏÐÎÊÒÅÐ ÝÍÄ ÃÀÌÁË ÊÎÌÏÀÍÈ (US) 2 3 1 1 9 0 1 (43) Äàòà ïóáëèêàöèè çà âêè: 27.01.2006 (45) Îïóáëèêîâàíî: 10.12.2007 Áþë. ¹ 34 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: US 44443197 À, 17.04.1984. RU 2183453 Ñ2, 20.06.2002. US 5330746 A, 19.07.1994. US 6383473 A, 07.05.2002. WO 172144 A, 04.10.2001. (86) Çà âêà PCT: US 02/41132 (20.12.2002) C 2 C 2 (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 13.07.2005 R U 2 3 1 1 9 0 1 (87) Ïóáëèêàöè PCT: WO 2004/054529 (01.07.2004) Àäðåñ äë ïåðåïèñêè: 123100, Ìîñêâà, à/ 48, Þðèäè÷åñêà ôèðìà "Æèãà÷åâ è Õðèñòîôîðîâ", ïàò.ïîâ. À.À.Õðèñòîôîðîâó, ðåã.¹ 509 (54) ÑÏÎÑÎÁ ÇÀÙÈÒÛ ÇÓÁΠÎÒ ÝÐÎÇÈÈ (57) Ðåôåðàò: Ðàñêðûâàþòñ ñïîñîáû ëå÷åíè è çàùèòû çóáîâ îò ýðîçèè ñ ïîìîùüþ èñïîëüçîâàíè îðàëüíûõ ñîñòàâîâ, ñîäåðæàùèõ ïîëèìåðíûå ìèíåðàëüíûå ïîâåðõíîñòíî-àêòèâíûå àãåíòû, èîíû ìåòàëëîâ, òàêèõ êàê îëîâî è öèíê, è èõ êîìáèíàöèè. Íàñòî ùèå ñïîñîáû îáåñïå÷èâàþò ïîâûøåííóþ ñîïðîòèâë åìîñòü çóáîâ ýðîçèîííîé äåìèíåðàëèçàöèè èëè ðàçëîæåíèþ è ïðåäîòâðàùàåò ïîâðåæäåíèå çóáîâ ïðè ïîñëåäóþùåì êîíòàêòå çóáîâ ñ ýðîçèîííûìè õèìè÷åñêèìè ïðîäóêòàìè, òàêèìè êàê êèñëîòíà ïèùà è íàïèòêè. 2 í. è 6 ç.ï. ô-ëû, 4 òàáë. Ñòðàíèöà: 1 RU R U (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 20.12.2002 ( ...

Preparation method of nostoc sphaeroides chewing gum

本发明公开了一种葛仙米口香糖的制作方法，具体制备方法包括：取葛仙米鲜品，清洗，晾干表面水分；采用反复冻融法处理表面无水的葛仙米鲜品，释放出来的蓝紫色液体即为葛仙米藻胆蛋白粗提液；将枸杞、桑椹和红枣捣碎后制成枸杞红枣桑椹提取物；采用碱酶法提取葛仙米多糖凝胶营养；称取水果粉、木糖醇、枸杞红枣桑椹提取物、葛仙米藻胆蛋白粗提液、葛仙米多糖凝胶营养液、葛仙米干粉，依次加入口香糖原料中经搅拌、挤压、裁减、冷冻、无菌包装等生产工艺步骤，即得葛仙米口香糖。本发明针对目前人们对于绿色、环保、营养食品的需要，制成的葛仙米口香糖，营养全面，食用方便，可以满足不同消费人群的需要，食用受众广，老少皆宜。

Chewing gum of improved release of its ingredients

FIELD: food industry, confectionary industry. SUBSTANCE: the suggested chewing gum contains conventional ingredients of chewing gums and, at least, one biologically decomposable polyether copolymer obtained due to polymerization of two or more cyclic esters due to opening the ring. The mentioned, at least, one biologically decomposable polyether copolymer has got molecular weight being under 150000 g/M. Chewing gum contains mainly no biologically undecomposable polymers. Moreover, the innovation deals with gum-foundation being one more independent object of innovation. AS a result, it is possible to obtain completely biodecomposable chewing gum at improved release of ingredients and its resistance to the action of softeners, emulsifiers and aromatizing agents. EFFECT: higher efficiency. 38 cl, 14 dwg, 67 ex, 2 tbl ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 303 365 (13) C2 (51) ÌÏÊ A23G 4/06 A23G 4/08 (2006.01) (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2005112221/13, 24.09.2002 (72) Àâòîð(û): ÀÍÄÅÐÑÅÍ Ëîíå (DK), ÂÈÒÒÎÐÔÔ Õåëëå (DK) (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 24.09.2002 (73) Ïàòåíòîîáëàäàòåëü(è): ÃÓÌËÈÍÊ À/Ñ (DK) (43) Äàòà ïóáëèêàöèè çà âêè: 20.11.2005 R U (45) Îïóáëèêîâàíî: 27.07.2007 Áþë. ¹ 21 2 3 0 3 3 6 5 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: WO 0147368 À, 05.07.2001.. ÅÐ 0711506 À, 15.05.1996.. JP 08196214, 06.08.1996.. (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 25.04.2005 (86) Çà âêà PCT: DK 02/00626 (24.09.2002) 2 3 0 3 3 6 5 R U Àäðåñ äë ïåðåïèñêè: 129090, Ìîñêâà, óë. Á.Ñïàññêà , 25, ñòð.3, ÎÎÎ "Þðèäè÷åñêà ôèðìà Ãîðîäèññêèé è Ïàðòíåðû", ïàò.ïîâ. Å.Å.Íàçèíîé, ðåã. ¹ 517 C 2 C 2 (87) Ïóáëèêàöè PCT: WO 2004/028267 (08.04.2004) (54) ÆÅÂÀÒÅËÜÍÀß ÐÅÇÈÍÊÀ Ñ ÓËÓ×ØÅÍÍÛÌ ÂÛÑÂÎÁÎÆÄÅÍÈÅÌ ÈÍÃÐÅÄÈÅÍÒΠÆÅÂÀÒÅËÜÍÎÉ ÐÅÇÈÍÊÈ (57) Ðåôåðàò: Íàñòî ùåå èçîáðåòåíèå îòíîñèòñ ê êîíäèòåðñêîé ïðîìûøëåííîñòè. Æåâàòåëüíà ðåçèíêà ñîäåðæèò ...

A kind of chewable composition and preparation method thereof containing phosphosilicate glass

本发明属于口腔保健技术领域，具体涉及一种含有磷硅酸盐玻璃的可咀嚼组合物(如口香糖)及其制备方法。本发明制备了一种含有磷硅酸盐玻璃的可咀嚼组合物和可咀嚼物，其中的磷硅酸盐玻璃与口腔唾液接触后会发生一系列的化学反应，最终发挥其在牙齿或牙龈表面的修复效果。而且，本发明可咀嚼组合物和可咀嚼物中的磷硅酸盐玻璃由于具有高溶出性、稳定pH值，可以促进多种基因表达，可以达到预防和治疗口腔感染、口腔溃疡及牙龈炎等口腔问题，同时通过其在牙齿上的再矿化，能够缓解牙齿过敏。本发明的制备方法工艺简单，原料廉价易得，适合工业化的大规模生产。

Chewing gum having deodorizing function and manufacturing method thereof

본 발명의 일 실시예에 따른 소취 기능을 갖는 껌 제조방법은 나무 알로에겔, 찻잎, 산초잎, 자소, 레몬, 솔잎, 감나무잎, 대나무잎, 당근잎, 쑥, 무화과잎, 뽕잎, 생강, 편백나무잎, 매화잎, 부추, 미나리, 자작나무 수액, 및 전나무잎을 포함하는 천연식물을 세척하고, 정제수를 가열하여 살균 처리하는 준비 단계; 상기 천연식물로부터 식물 엑기스를 추출하는 추출 단계; 상기 정제수에 점도 증진제를 투입하고 81 ~ 89℃의 온도로 가열하면서 1 ~ 2시간 동안 혼합하여 소취 기초제를 마련하는 제1 증점 단계; 상기 소취 기초제에 상기 식물 엑기스를 투입하고 60 ~ 85℃의 온도로 가열하면서 30분간 혼합하여 소취 혼합물을 마련하는 혼합 단계; 상기 소취 혼합물에 상기 점도 증진제를 추가로 투입하고 80 ~ 85℃의 온도로 가열하면서 30분간 혼합하여 소취 조성물을 제조하는 제2 증점 단계; 및 중량 %로 껌 베이스 20 ~ 30%, 당류 65 ~ 75%, 껌 첨가제 1 ~ 2% 및 상기 소취 조성물 1 ~ 5%를 혼합하여 소취 기능을 갖는 껌를 제조하는 마무리 단계;를 포함한다. The method for manufacturing gum having a deodorizing function according to an embodiment of the present invention includes tree aloe gel, tea leaves, wild pepper leaves, perilla, lemon, pine needles, persimmon leaves, bamboo leaves, carrot leaves, mugwort, fig leaves, mulberry leaves, ginger, cypress leaves. A preparation step of washing natural plants including tree leaves, plum leaves, leek, water parsley, birch sap, and fir leaves, and heating purified water to sterilize; an extraction step of extracting a plant extract from the natural plant; A first thickening step of preparing a deodorizing base agent by adding a viscosity enhancer to the purified water and mixing for 1 to 2 hours while heating to a temperature of 81 to 89°C; A mixing step of preparing a deodorizing mixture by adding the plant extract to the deodorizing base agent and mixing for 30 minutes while heating to a temperature of 60 to 85°C; a second thickening step of additionally adding the viscosity enhancer to the deodorizing mixture and mixing for 30 minutes while heating to a temperature of 80 to 85° C. to prepare a deodorizing composition; and a finishing step of preparing a gum having a deodorizing function by mixing 20 to 30% of the gum base, 65 to 75% of sugar, 1 to 2% of the gum additive, and 1 to 5% of the deodorizing composition by weight%.

Confectionery composition including an elastomeric component, a cooked saccharide component, and a flavor

The present invention relates to edible confectionary compositions including cooked saccharide, an elastomeric component and at least two flavor components.

Chewing Gum Granules For Compressed Chewing Gum

A chewing gum granule containing gum base, wherein the chewing gum granule is substantially ball-shaped, the chewing gum granule has an average diameter below 1900 μm, and wherein the surface of the chewing gum granule is provided with 0.5 to 18% by weight of free-flowing agent. With the present invention improved free-flow properties of the chewing gum granules may be obtained.

Compressed Chewing Gum Tablet

A compressed chewing gum tablet includes at least a first and a second chewing gum module, the first chewing gum module including a first chewing gum composition including at least a first active ingredient and chewing gum granules containing gum base, the second chewing gum module including a second chewing gum composition including at least a second active ingredient and chewing gum granules containing gum base, wherein the first active ingredient is a pharmaceutically active ingredient, and the second active ingredient is selected from the group consisting of pharmaceutically active ingredients and enhancers, wherein the gum base content of the first and second chewing gum modules is different.

Confectionery product containing active and/or reactive components and methods of production thereof

The invention relates to a confectionery product comprising an extruded body portion, the body portion having a plurality of capillaries disposed therein, one or more of the capillaries being at least partially filled with a fill material which is a different material from that of the extruded body portion, the fill material and optionally the body portion comprising various active and/or reactive components. Some embodiments are designed to provide sequential release profiles. The invention also relates to a process for the manufacture of the same.

Soft coated powder centre-filled gum

The present invention relates to a chewing gum composition that includes one or more layers surrounding a central core, at least one of the one or more layers surrounding the central core is a layer of chewing gum, wherein the central core includes a first material in a powder form having a first average grain size, and wherein the outermost layer of the one or more layers includes a coating that includes a second material in a powder form having a second average grain size.

Buffered gum base for high pH release

A chewing gum composition with high pH-release includes an insoluble gum base matrix and a soluble bulk portion, wherein the gum base matrix and the bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion. Furthermore, a method of producing a chewing gum core, wherein a gum base matrix and a bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion, and the gum base matrix includes a first amount of buffer from 2 to 20 percent by weight of the gum base matrix before mixing with the bulk portion.

Compressed chewing gum tablet

A compressed chewing gum tablet includes at least a first and a second chewing gum module, the first chewing gum module including a first chewing gum composition including at least a first active ingredient and chewing gum granules containing gum base, the second chewing gum module including a second chewing gum composition including at least a second active ingredient and chewing gum granules containing gum base, wherein the first active ingredient is a pharmaceutically active ingredient, and the second active ingredient is selected from the group consisting of pharmaceutically active ingredients and enhancers, wherein the gum base content of the first and second chewing gum modules is different.

Compressed chewing gum tablet

A compressed chewing gum tablet includes at least a first and a second chewing gum module, the first chewing gum module including a first chewing gum composition including at least a first active ingredient and chewing gum granules containing gum base, the second chewing gum module including a second chewing gum composition including at least a second active ingredient and chewing gum granules containing gum base, wherein the first active ingredient is a pharmaceutically active ingredient, and the second active ingredient is selected from the group consisting of pharmaceutically active ingredients and enhancers, wherein the gum base content of the first and second chewing gum modules is different.

Confectionery product containing active and/or reactive components and methods of productions thereof

The invention relates to a confectionery product comprising an extruded body portion, the body portion having a plurality of capillaries disposed therein, one or more of the capillaries being at least partially filled with a fill material which is a different material from that of the extruded body portion, the fill material and optionally the body portion comprising various active and/or reactive components. Some embodiments are designed to provide sequential release profiles. The invention also relates to a process for the manufacture of the same.

Chewing gum with healthcare functions and cyclocarya paliurus

本发明公开了一种具有保健功效的青钱柳口香糖，具有辅助降血糖调节血脂等保健功能。青钱柳味甘甜，可生津止渴，具有降血糖、调血脂、降血压等功效含有特征的甜味成分。其作为原料添加入口香糖，不仅能大大减少传统口香糖中其它甜味剂的用量或者替代甜味剂，长期咀嚼还能有效预防和改善血糖、血脂水平。本发明采用现代纯化技术对原料进行加工，最大限度的保留了青钱柳的活性成分和甜味成分，易于吸收，功效更加显著。制得的口香糖适合各种人群食用，尤其适合血糖、血脂紊乱的患者及特殊人群食用。

KITS AND COMPOSITIONS FOR CARE

ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (51) ÌÏÊ 7 (11) 2003 130 736 (13) A A 61 K 7/16 ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÇÀßÂÊÀ ÍÀ ÈÇÎÁÐÅÒÅÍÈÅ (21), (22) Çà âêà: 2003130736/15, 15.03.2002 (71) Çà âèòåëü(è): ÄÇÅ ÏÐÎÊÒÅÐ ÝÍÄ ÃÝÌÁË ÊÎÌÏÀÍÈ (US) (30) Ïðèîðèòåò: 19.03.2001 US 60/276,978 19.03.2001 US 60/276,979 (43) Äàòà ïóáëèêàöèè çà âêè: 10.03.2005 Áþë. ¹ 7 (74) Ïàòåíòíûé ïîâåðåííûé: Åãîðîâà Ãàëèíà Áîðèñîâíà (87) Ïóáëèêàöè PCT: WO 02/07427 (26.09.2002) Àäðåñ äë ïåðåïèñêè: 129010, Ìîñêâà, óë. Á.Ñïàññêà , 25, ñòð.3, ÎÎÎ "Þðèäè÷åñêà ôèðìà Ãîðîäèññêèé è Ïàðòíåðû", ïàò.ïîâ. Ã.Á. Åãîðîâîé R U Ôîðìóëà èçîáðåòåíè 1. Êîìïîçèöè äë óõîäà çà ïîëîñòüþ ðòà, âêëþ÷àþùà (à) ïîëèáóòåí ñ ìîëåêóë ðíîé ìàññîé îò 300 äî 3000, ïðåäïî÷òèòåëüíî îò 750 äî 1500; è (b) îäèí èëè íåñêîëüêî íîñèòåëåé äë óõîäà çà ïîëîñòüþ ðòà, âûáðàííûõ èç ãðóïïû, ñîñòî ùåé èç àáðàçèâíûõ ïîëèðóþùèõ âåùåñòâ, áóôåðíûõ ñðåäñòâ, âîäû, ïîâåðõíîñòíî-àêòèâíûõ âåùåñòâ, ïîäñëàñòèòåëåé, àðîìàòèçàòîðîâ, çàãóñòèòåëåé, çàìóòíèòåëåé, óâëàæí þùèõ ñðåäñòâ, êñèëèòà è èõ ñìåñåé; ãäå êîìïîçèöè íå âë åòñ ñàìîïîääåðæèâàþùåéñ è ãäå êîìïîçèöè íå âë åòñ æåâàòåëüíîé ðåçèíêîé. 2. Êîìïîçèöè äë óõîäà çà ïîëîñòüþ ðòà ïî ï.1, êîòîðà äîïîëíèòåëüíî âêëþ÷àåò êîìïîíåíò, àêòèâíûé â îòíîøåíèè óõîäà çà ïîëîñòüþ ðòà, âûáðàííûé èç ãðóïïû, ñîñòî ùåé èç ñðåäñòâ, ïðåï òñòâóþùèõ îáðàçîâàíèþ êîíêðåìåíòà; èñòî÷íèêîâ ôòîðèä-èîíà; èñòî÷íèêîâ èîíà äâóõâàëåíòíîãî îëîâà; îòáåëèâàþùèõ ñðåäñòâ; ïðîòèâîìèêðîáíûõ ñðåäñòâ; ñðåäñòâ îò çóáíîãî íàëåòà; ïðîòèâîâîñïàëèòåëüíûõ ñðåäñòâ; ïèòàòåëüíûõ âåùåñòâ; àíòèîêñèäàíòîâ; ïðîòèâîâèðóñíûõ ñðåäñòâ; ïðîòèâîãðèáêîâûõ ñðåäñòâ; àíàëüãåòè÷åñêèõ ñðåäñòâ è àíåñòåòèêîâ; àíòàãîíèñòîâ Í-2; êîìïîíåíòîâ, îòëè÷íûõ îò ïîëèáóòåíà, êîòîðûå ïðèäàþò îùóùåíèå ÷èñòîòû çóáàì; îòäóøåê è àãåíòîâ, ïðèäàþùèõ íóæíîå îùóùåíèå; è èõ ñìåñåé, ïðåäïî÷òèòåëüíî, êîìïîíåíò, àêòèâíûé â îòíîøåíèè óõîäà çà ïîëîñòüþ ðòà, âûáèðàþò èç ãðóïïû, ñîñòî ùåé èç òðèêëîçàíà, ïèùåâîé ñîäû, ôòîðèäà íàòðè , íèòðàòà êàëè , íèòðàòà íàòðè ...

Method of preparing cyclohexane carboxylic acid derivatives

The present invention relates to novel cyclohexanecarboxylic acid and its derivatives represented by the general formula: <IMAGE> (wherein R1 is selected from the group consisting of hydrogen or methyl; R2 is selected from the group consisting of hydroxyl, lower alkoxy with 1-6 carbons or amino acid rest. In case R1 is hydrogen, however, R2 means amino acid rest, which of all the compounds of the present invention are entirely novel ones which have never been in any printed publications, possessing a high degree of pharmacological activities such as anti-allergic, anti-inflammatory, anti-ulcerative, antibacterial, anti-thrombotic and liver-function-improving activities, and therefore, these compounds are useful as medicines, and besides, these compounds are surface-active and, therefore, useful as additives for toothpaste and shampoo, as surface active agents for detergents, dispersing agents, emulsifying agents and cosmetics, as anticarious agents, and also in industrial fields the aforesaid compounds are useful as detergents for keeping textiles soft, as additives for lubricating oil, as anti-rust agents, additives for plastics and also as metal-capturing agent, ion-floating agents and emulsifying agents for other industrial purposes).

Antibacterial agent

Preparation for saliva flow

The present invention is directed to products that promote saliva generation in the mouth through the use of various food grade acceptable acids. The products that enhance saliva production are preferably foods that are consumed in the mouth over a period of time of a minute or longer such as chewing gums, breath films, toothpaste and lozenges.

Preparation for saliva flow

The present invention is directed to products that promote saliva generation in the mouth through the use of various food grade acceptable acids. The products that enhance saliva production are preferably foods that are consumed in the mouth over a period of time of a minute or longer such as chewing gums, breath films, toothpaste and lozenges.