30-06-2016 дата публикации
Номер: US20160185727A1
Автор:
Boren Brant Clayton,
Chen Qing,
Ching Brett Weylan,
Fotsing Joseph R.,
Karanewsky Donald,
Lapera Stephanie,
Petrovic Goran,
Servant Guy,
Tachdjian Catherine,
Vong Binh,
ZHANG Hong
Принадлежит:
Disclosed herein are 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acid compounds having useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener. 3. The compound of claim 1 , wherein{'sup': 4', '4A, 'sub': 3-7', '1-6, 'Ris selected from the group consisting of optionally substituted Ccarbocyclyl, optionally substituted aryl, optionally substituted 5-10 membered heteroaryl, optionally substituted 3-10 membered heterocyclyl and Calkyl substituted with one or two R;'}{'sup': 4A', '7', '8', '9', '9, 'sub': 1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'each Ris independently selected from the group consisting of halo; 5-10 membered heteroaryl optionally substituted with one or more substituent selected from the group consisting of halo, C-Calkyl, C-Calkoxy, C-Chaloalkyl, and C-Chaloalkoxy; 3-10 membered heterocyclyl optionally substituted with one or more substituent selected from the group consisting of halo, C-Calkyl, C-Calkoxy, C-Chaloalkyl, and C-Chaloalkoxy; —NRR; —SR; and —OR;'}{'sup': 7', '10, 'sub': 1-6', '3-7, 'Ris selected from the group consisting of hydrogen, —C(═O)OR, Calkyl, Ccarbocyclyl, aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;'}{'sup': '8', 'sub': 1-6', '3-7, 'Ris selected from the group consisting of hydrogen, Calkyl, Ccarbocyclyl, aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;'}{'sup': '9', 'sub': 1-6', '3-7', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '3', '7', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'Ris selected from the group consisting of hydrogen; Calkyl; Ccarbocyclyl optionally ...
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