28-03-2013 дата публикации
Номер: US20130078256A1
The invention is related to compounds of Formula (I): 3. The compound of claim 1 , wherein A is —C(R)—.4. The compound of claim 3 , wherein A is —C(O)—.5. The compound of claim 4 , wherein Ris alkyl or haloalkyl.6. The compound of claim 5 , wherein D is a covalent bond or alkylene.7. The compound of claim 6 , wherein Ris H claim 6 , alkyl claim 6 , haloalkyl claim 6 , cycloalkyl claim 6 , or cycloalkyl substituted with CH—C(O)—OH claim 6 , —CH—C(O)—NH(p-methoxybenzyl) or —CH—C(O)—NH.8. The compound of claim 1 , wherein n is at least 1 claim 1 , and at least one Z is —CN.9. The compound of claim 5 , wherein:D is alkylene, alkenylene or alkynylene; and{'sup': 1', '7', '7', '7, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris H, halo, alkyl, cycloalkyl, cycloalkyl substituted with —CH—C(O)—OH, —CH—C(O)—O-alkyl, —CH—C(O)—NH(p-methoxybenzyl) or —C—C(O)—NH; —OH, alkoxy, —CN, —C(O)—N(R), —O-alkylene-OH, —O-alkylene-O-acyl, —S(O)—N(R), —O—C(O)—N(R), —C(O)—Oalkyl, or —C(O)—OH.'}10. The compound of claim 1 , wherein:{'sup': 6', '5, 'sub': '2', 'A is a covalent bond, —C(R)—, —O— or —NR—;'}D is a covalent bond or alkylene; and{'sup': '2', 'Ris alkyl.'}11. The compound of claim 10 , wherein Ris H or alkyl.12. The compound of claim 1 , wherein:X and Y are both O;{'sup': '3', 'Ris phenyl;'}{'sub': 3', '2', '2, 'each Z is independently selected from the group consisting of —CH, —CN, —CH═CH—CN, —CH—CH—CN, and Cl;'}n is 2;{'sub': 2', '3, 'A is selected from the group consisting of —C(O)—, —C(N—OH)—, —CF—, —CHF—, —CH(OCH)—, —CH(CN)—, —O—, and —NH—; and'}{'sup': 1', '7', '7', '7', '7, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2, 'D-Ris selected from the group consisting of H, alkyl, haloalkyl, cycloalkylalkyl, cycloalkylalkyl substituted with CH—C(O)—OH, —CH—C(O)—NH(p-methoxybenzyl) or —CH—C(O)—NH; hydroxyalkyl, cyanoalkyl, -alkylene-C(O)—N(R), alkylene-S(O)—N(R), -alkylene-O—C(O)—N(R), -alkylene-C(O)—Oalkyl, -alkylene-C(O)—OH, -alkenylene-C(O)—Oalkyl, -alkenylene-C(O)—N(R), ...
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