22-10-2020 дата публикации
Номер: US20200333024A1
Принадлежит:
A method is provided for a condition related to the activity of a protease through the administration of a θ-defensin, analog, or derivative is described. Suitable proteases include metalloproteases and cysteine proteases such as Cathepsin-C. The θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. 1. A method of treating a condition resulting from activity of a protease in an animal , comprising:determining that the animal has the condition related to activity of the protease, andadministering a pharmacologically acceptable formulation of a θ-defensin to the animal in an amount effective to inhibit the protease.2. The method of claim 1 , wherein the θ-defensin is a mini-θ-defensin.3. The method of claim 1 , wherein the θ-defensin is selected from the group consisting of SEQ. ID NO. 8 claim 1 , SEQ. ID NO. 11 claim 1 , SEQ. ID NO. 12 claim 1 , SEQ. ID NO. 13 claim 1 , SEQ. ID NO. 14 claim 1 , SEQ. ID NO. 15 claim 1 , SEQ. ID NO. 16 claim 1 , SEQ. ID NO. 17 claim 1 , and SEQ. ID NO. 18.4. The method of claim 1 , wherein the θ-defensin is selected from the group consisting of SEQ. ID NO. 8 claim 1 , SEQ. ID NO. 14 claim 1 , and SEQ. ID NO. 15.5. The method of claim 1 , wherein the mini-θ-defensin is selected from the group consisting of SEQ. ID NO. 11 claim 1 , SEQ. ID NO. 12 claim 1 , and SEQ. ID NO. 13.7. The method of claim 1 , wherein the mini-θ-defensin is SEQ. ID NO. 12.8. The method of claim 1 , wherein the protease is a metalloprotease.9. The method of claim 1 , wherein the protease is a cysteine protease.10. The method of claim 9 , wherein the cysteine protease is Cathepsin-C.11. The method of claim 1 , wherein the θ-defensin is administered parenterally.12. The method of claim 1 , wherein the θ-defensin is administered topically.13. The method of claim 1 , wherein the θ-defensin is administered orally.14. The method of claim 1 , wherein the condition comprises a dysregulation of the protease. This application ...
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