METHOD FOR PRODUCING TRIARYLORGANOBORATES

The invention relates to a process for preparing triaryl organoborates proceeding from organoboronic esters in the presence of an n-valent cation 1/n K, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms. 1. Process for preparing triaryl organoborates of the formula 1/n KRB—R(IV) , where one equivalent of organoboronic ester of the formula B—R(OR)(OR) (I) is initially charged together with 1/n equivalents of salt K nX (II) and 3 equivalents of metal M in a solvent or a solvent mixture S1 , 3 equivalents of a haloaromatic R—Y (III) are added , an auxiliary L and optionally a second organic solvent or solvent mixture S2 is added and the compound 1/n K RB—R(IV) is separated off with the organic phase and{'sup': '1', 'sub': 1', '22', '3', '22', '3', '22', '5', '7', '7', '13, 'Ris an optionally hydroxyl- and/or alkoxy- and/or acyloxy- and/or halogen-substituted C- to C-alkyl, C- to C-alkenyl, C- to C-alkynyl, C- to C-cycloalkyl or C- to C-aralkyl radical,'}{'sup': 2', '3', '2', '3, 'sub': 1', '22', '3', '7, 'Rand Rare independently an optionally branched C- to C-alkyl radical or an optionally alkyl-substituted C- to C-cycloalkyl radical or Rand Rtogether form a 2-8-membered carbon bridge which is optionally substituted by alkyl and/or interrupted by oxygen atoms,'}{'sup': '4', 'sub': 6', '10', '1', '4', '1', '4, 'Ris a C- to C-aryl radical optionally substituted by at least one radical selected from halogen, C- to C-alkyl, trifluoromethyl, C- to C-alkoxy, trifluoromethoxy, phenyl and phenoxy,'}K is an organocation of valency n and having any substitution, based on nitrogen, phosphorus, oxygen, sulfur and/or iodine, and{'sup': 2', '3, 'L is an auxiliary that forms a complex of sparing solubility in S1 and/or S2 with M salts MY(OR), MY(OR) and MXY, where L is a Lewis-basic compound, especially selected from the group consisting of open chain ...

Diazomethylation reagent and process for using it

The present invention relates compounds useful as reagents for the diazomethylation reaction, their preparation and the use thereof as reagents in a method for the diazomethylation reaction of aromatic substrates. It relates in particular to a compound of formula (I) wherein E is an electron withdrawing group.

TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION

The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: 19-. (canceled)11. The process of claim 10 , wherein the second suitable solvent is chloroform claim 10 , dichloromethane claim 10 , nitromethane claim 10 , dimethylforamide claim 10 , diethyl ether claim 10 , tetrahydrofuran claim 10 , dioxane claim 10 , dichloroethane claim 10 , or hexane.12. The process of claim 10 , wherein step (b) is carried out at room temperature.13. The process of claim 10 , wherein step (b) is carried out at a temperature of 50-140° C.14. The process of claim 10 , wherein the compound is maintained in the second suitable solvent for 10-50 hours.15. The process of claim 10 , wherein A is a phenyl or pyridine.16. The process of claim 10 , wherein A is a furan claim 10 , thiophene claim 10 , pyrrole claim 10 , thiazole claim 10 , imidazole claim 10 , pyrazole claim 10 , isooxazole claim 10 , isothiazole claim 10 , naphthalene claim 10 , anthracene claim 10 , pyrimidine claim 10 , pyrazine claim 10 , pyridazine claim 10 , indole claim 10 , indoline claim 10 , benzofuran claim 10 , benzothiophene claim 10 , or quinolone.2037-. (canceled) This application claims priority of U.S. Provisional Application Nos. 62/192,789, filed Jul. 15, 2015; 62/192,462, filed Jul. 14, 2015; 62/063,246, filed Oct. 13, 2014; and 62/062,508, filed Oct. 10, 2014, the contents of each of which are hereby incorporated by reference.Throughout this application various publications are referenced. The disclosures of these documents in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains.Fluorine atoms are often introduced into organic molecules to enhance their pharmacological properties such as solubility, metabolic and oxidative stability, lipophilicity, and bioavailability. Among the fluorine containing functional groups, ...

Iodonium analogs as inhibitors of nadph oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof

Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.

HYPERVALENT IODINE CF2CF2X REAGENTS AND THEIR USE

Described herein are hypervalent iodine reagents. 2. The compound according to claim 1 ,wherein{'sup': 1', '1', '2', '2', '3, 'sub': a', 'c', 'd', 'e, 'claim-text': [{'sub': 1', '1, 'a is 0 or 1 and Lis selected from —O—,or —C-alkyl,'}, {'sup': '1', 'Ris phenyl,'}, {'sup': '2', 'sub': 1-4', '1-2, 'c is 0 or 1 and Lis a C-alkyl, in particular C-alkyl,'}, {'sup': 2', '5', '5', '5, 'sub': '2', 'claim-text': {'sup': '5', 'sub': 1-4', '1-2, 'with Rbeing selected from —H, —C-alkyl, in particular —C-alkyl, C(═O)—O-tertbutyl (Boc),'}, 'd is 0 or 1 and Ris selected from —C(═O)—O—, —N(R)—, —N(R)—C(═O)—, and —N(R)—SO—,'}, {'sup': '3', 'sub': 1-6', '1-3', '2', '1-4', '1-5', '2', '1-2', '1-4', '2', '1-2', '2', '1-2', '1-4', '2', '1-2', '1', '2, 'e is 0 or 1 and Lis selected from —C-alkyl-, in particular C-alkyl, -phenyl-, —[(CH)—O—]—, —[(CH)—O—]—(CH)—, and —[(CH)—O—]- triazole-[(CH)—O—]—(CH)—, and'}, {'sub': 1-4', '2-4', '2', '1-3', '3', '2', '3', '3, 'E is selected from —H, —O-alkyl, —C-alkynyl, —NO, halogene, particularly —I, —C—N, —N3, —CN, —SOF, —CHO, —C(═O)—O-tertbutyl (Boc), —C≡C—Si(CH), 3-Oxo-4,7,7-trimethyl-2- oxabicyclo [2.2.1]heptane-1-carbonyl (camphanic carbonyl), an affinity tag or a fluorescent dye, or'}], 'R is a nucleophile of formula III, -L-R-L-R-L-E (III), wherein'}{'sup': 4', '6, 'sub': f', 'g, 'claim-text': [{'sup': '4', 'sub': '1-2', 'f is 0 or 1 and Lis selected from C-alkyl,'}, {'sup': 6', '8', '8, 'claim-text': {'sup': '8', 'sub': 1-4', '1-2', '2-4', '2, 'with Rbeing selected from —H, —O-alkyl, in particular C-alkyl, —C-alkenyl, in particular C-alkenyl, —C(═O)—O-tertbutyl (Boc),'}, 'g is 0 or 1 and Ris selected from —N(R)—, —C(═O)—N(R)—,'}, {'sub': 1-4', '1-2', '2-4', '2', '3, 'G is selected from —H, —O-alkyl, in particular C-alkyl, —C-alkenyl, in particular C-alkenyl, —N, —C(═O)—O-tertbutyl (Boc).'}], 'R is a nucleophile of formula IV, -L-R-G (IV), wherein'}3. The compound according to claim 1 , wherein the bioorthogonal group is azide claim 1 , pikolyl ...

IODONIUM ANALOGS AS INHIBITORS OF NADPH OXIDASES AND OTHER FLAVIN DEHYDROGENASES; FORMULATIONS THEREOF; AND USES THEREOF

Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity. 2. The method of claim 1 , wherein X is a halide claim 1 , an alkyl sulfonate claim 1 , an aryl sulfonate claim 1 , a phosphate claim 1 , or a nitrate.3. The method of claim 1 , wherein X is chloride claim 1 , bromide claim 1 , iodide claim 1 , CHSO— claim 1 , CHSO— claim 1 , CFSO— claim 1 , 4-CHCHSO— claim 1 , or CHSO—.4. The method of claim 1 , wherein m is 1 or 2 and n is 1 or 2.5. The method of claim 1 , wherein Z is O claim 1 , CH claim 1 , or NRwhere Ris C-Calkyl claim 1 , C-Chaloalkyl claim 1 , or C-Calkanoyl.6. The method of claim 1 , wherein Z is O claim 1 , CH claim 1 , or NRwhere Ris C-Calkanoyl.7. The method of claim 1 , wherein Z is O.8. The method of claim 1 , wherein Z is CH.9. The method of claim 1 , wherein the cancer is colon cancer claim 1 , kidney cancer (renal cell) claim 1 , melanoma claim 1 , leukemia claim 1 , prostate cancer claim 1 , breast cancer claim 1 , squamous lung cancer claim 1 , ovarian cancer claim 1 , pancreatic cancer claim 1 , Non-Hodgkin lymphoma claim 1 , or Glioblastoma Multiforme.10. The method of claim 9 , wherein the cancer is colon cancer.12. The method of claim 11 , wherein X is a halide claim 11 , an alkyl sulfonate claim 11 , an aryl sulfonate claim 11 , a phosphate claim 11 , or a nitrate.13. The method of claim 11 , wherein X is chloride claim 11 , bromide claim 11 , iodide claim 11 , CHSO— claim 11 , CHSO— claim 11 , CFSO— claim 11 , 4-CHCHSO— claim 11 , or CHSO—.14. The method of claim 11 , wherein m is 1 or 2 and n is 1 or 2.15. The method of claim 11 , wherein m is 1 claim 11 , 2 claim 11 , or 3 and n is 1 claim 11 , 2 claim 11 , or 3.16. The method of claim 11 , wherein m is 1 claim 11 , 2 claim 11 , 3 claim 11 , or 4 and n is 1 claim 11 , 2 claim 11 , 3 claim 11 , or 4.17. The method of claim 11 , wherein the cancer is colon cancer claim 11 , kidney cancer (renal cell) claim 11 , melanoma claim 11 , leukemia claim 11 ...

Onium salt compound, chemically amplified resist composition and patterning process

An onium salt having formula (1) serving as an acid diffusion inhibitor and a chemically amplified resist composition comprising the acid diffusion inhibitor are provided. When processed by lithography, the resist composition exhibits a high sensitivity, and excellent lithography performance factors such as CDU and LWR.

HYPERVALENT IODINE CF2CF2X REAGENTS AND THEIR USE

A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for fluoroethylation of compounds carrying a reactive group. A preferred compound carrying a reactive group is cystein in any environment such as peptide targets. 2. The compound of claim 1 , wherein R is selected from the group consisting of unsubstituted or substituted imidazoles claim 1 , unsubstituted or substituted pyrazoles claim 1 , unsubstituted or substituted benzimidazoles claim 1 , unsubstituted or substituted thiophenols claim 1 , unsubstituted or substituted phenols claim 1 , like 4-methoxyphenols claim 1 , ethyl-4-hydroxybenzoates claim 1 , 4-bromophenols claim 1 , unsubstituted or substituted pyridine-thiols claim 1 , unsubstituted or substituted 2-mercaptobenzothiazoles claim 1 , potassium cyanide and diethylphosphite.3. The compound of claim 1 , wherein claim 1 , R is selected from the group consisting of imidazole claim 1 , pyrazole claim 1 , benzimidazole claim 1 , thiophenol claim 1 , 4-methoxyphenol claim 1 , ethyl-4-hydroxybenzoate claim 1 , 4-bromophenols claim 1 , pyridine-2-thiol claim 1 , 2-mercaptobenzothiazoles claim 1 , potassium cyanide and diethylphosphite claim 1 , more preferred imidazole claim 1 , pyrazole claim 1 , benzimidazole claim 1 , thiophenol claim 1 , 4-methoxyphenol claim 1 , ethyl-4-hydroxybenzoate claim 1 , 4-bromophenols and pyridine-2-thiol.4. The compound of claim 2 , wherein R is substituted with a substituent independently from each other selected from the group consisting of halogens claim 2 , linear or branched claim 2 , unsubstituted or halogen substituted C1 C4 alkyl or C1 C4 alkenyl or C1 C4 alkinyl or C1 C4 alkoxy or C1 C4 alkyl carboxylate groups claim 2 , or the substituent may be a linker or spacer coupled to a desired group such as a functional group claim 2 , said linker preferably being an optionally halogen substituted aliphatic group.5. The compound ...

TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION

The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure: 2. The process of claim 1 , wherein the suitable solvent is chloroform claim 1 , dichloromethane claim 1 , nitromethane claim 1 , dimethylformamide claim 1 , diethyl ether claim 1 , tetrahydrofuran claim 1 , dioxane claim 1 , dichloroethane claim 1 , or hexane.3. The process of claim 1 , wherein the trifluoromethoxylating agent is Togni reagent I or Togni reagent II.4. The process of claim 1 , wherein the base is cesium carbonate or sodium hydride.5. The process of claim 1 , wherein A is a phenyl or pyridine.6. The process of claim 1 , wherein A is a furanyl claim 1 , thiophenyl claim 1 , pyrrolyl claim 1 , thiazolyl claim 1 , imidazolyl claim 1 , pyrazolyl claim 1 , isooxazolyl claim 1 , isothiazolyl claim 1 , naphthalenyl claim 1 , anthracenyl claim 1 , pyrimidinyl claim 1 , pyrazinyl claim 1 , pyridazinyl claim 1 , indolyl claim 1 , indolinyl claim 1 , benzofuranyl claim 1 , benzothiophenyl claim 1 , or quinolonyl.1035.-. (canceled)38. The process of claim 2 , wherein the base is cesium carbonate or sodium hydride.39. The process of claim 3 , wherein the base is cesium carbonate or sodium hydride.40. The process of claim 2 , wherein A is a phenyl or pyridine.41. The process of claim 3 , wherein A is a phenyl or pyridine.42. The process of claim 4 , wherein A is a phenyl or pyridine.43. The process of claim 2 , wherein A is a furanyl claim 2 , thiophenyl claim 2 , pyrrolyl claim 2 , thiazolyl claim 2 , imidazolyl claim 2 , pyrazolyl claim 2 , isooxazolyl claim 2 , isothiazolyl claim 2 , naphthalenyl claim 2 , anthracenyl claim 2 , pyrimidinyl claim 2 , pyrazinyl claim 2 , pyridazinyl claim 2 , indolyl claim 2 , indolinyl claim 2 , benzofuranyl claim 2 , benzothiophenyl claim 2 , or quinolonyl.44. The process of claim 3 , wherein A is furanyl claim 3 , thiophenyl claim 3 , pyrrolyl claim 3 , thiazolyl claim 3 , imidazolyl ...

OXIDIZING AGENT FOR ELECTRON MEDIATOR

Provided are an oxidizing agent for an electron mediator, said oxidizing agent including a trivalent iodobenzene compound; an analyte measurement reagent including the oxidizing agent; a sensor supporting the oxidizing agent; and a method for the electrochemical measurement of an analyte using the oxidizing agent. 1. An oxidant for an electron mediator , comprising a trivalent iodobenzene compound.3. The oxidant according to claim 2 , wherein in formula I claim 2 , Rto Rare independently a hydrogen atom claim 2 , halogen claim 2 , a nitro group claim 2 , or a linear or branched claim 2 , saturated or unsaturated claim 2 , optionally substituted Chydrocarbon group claim 2 ,{'sub': '1-10', 'X and Y are independently a hydroxyl group, an acetoxy group, a trifluoroacetoxy group, a tosyloxy group, a methanesulfonyloxy group, a trifluoromethanesulfonyloxy group, or a linear saturated halogenated Chydrocarbon group;'}{'sub': 1', '5', '1-4, 'in formula II, Rto Rare independently a hydrogen atom, halogen, a nitro group, a carboxyl group, or a linear or branched, saturated or unsaturated, optionally substituted Chydrocarbon group; and'}{'sub': 1', '4', '1-4, 'in formula III, Rto Rare independently a hydrogen atom, halogen, a nitro group, or a linear or branched, saturated or unsaturated, optionally substituted Chydrocarbon group,'}{'sub': '1-6', 'Z is halogen, a hydroxyl group, an acetoxy group, a trifluoroacetoxy group, or a linear or branched Calkylperoxy group,'}{'sub': 1', '2', '1', '2, 'Wand Ware independently a methyl group, or Wand Wtogether form oxo (═O).'}4. The oxidant according to claim 1 , wherein the trivalent iodobenzene compound is selected from the group consisting of iodosobenzene claim 1 , 2 claim 1 ,4 claim 1 ,6-trimethyl(diacetoxyiodo)benzene claim 1 , [bis(trifluoroacetoxy)iodo]pentafluorobenzene claim 1 , [hydroxy(tosyloxy)iodo]benzene claim 1 , 2-iodosobenzoic acid claim 1 , 1-fluoro-3 claim 1 ,3-dimethyl-1 claim 1 ,2-benziodoxol claim 1 , and [hydroxy( ...

트리아릴-유기 보레이트를 제조하는 방법

본 발명은 보론산 에스테르로부터의 트리아릴-유기 보레이트를 제조하는 방법, 광개시제 시스템에 있어서의 이러한 물질의 용도, 이러한 광개시제 시스템을 포함하는 광중합체 조성물, 상기 광중합체 조성물을 포함하는 홀로그래픽 매체 및 각각의 홀로그램에 관한 것이다.

Compounds and methods

본 발명 대상은 일반적으로 CNS 질환, 질병, 및/또는 손상의 치료 및/또는 예방 화합물 및 방법에 관한 것이다. 일 양태에서, 본 발명 대상은 신경 보호제 및/또는 신경 재생제로서 포스포디에스테라아제 1(PDE1)의 억제제에 관한 것이다. 추가의 양태에서, 본 발명 대상은 CNS 질환 또는 질병의 발병 위험에 있는 개체에 관한 것이다. The present subject matter generally relates to compounds and methods for the treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the present subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective and/or nerve regenerative agents. In a further aspect, the subject of the present invention relates to an individual at risk of developing a CNS disease or condition.

COMPOUNDS AND METHODS

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2017 112 989 A (51) МПК A61K 31/519 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2017112989, 17.09.2015 (71) Заявитель(и): ИНТРА-СЕЛЛУЛАР ТЕРАПИЗ, ИНК. (US) Приоритет(ы): (30) Конвенционный приоритет: 17.09.2014 US 62/051,735; 18.09.2014 US 62/052,283 29 R U (43) Дата публикации заявки: 17.10.2018 Бюл. № (72) Автор(ы): ЛИ Пэн (US), ЧЖЭН Хайлинь (US), ЧЖАО Цзюнь (US), УЭННОГЛ Лоуренс (US) (85) Дата начала рассмотрения заявки PCT на национальной фазе: 17.04.2017 US 2015/050814 (17.09.2015) (87) Публикация заявки PCT: Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (54) СОЕДИНЕНИЯ И СПОСОБЫ (57) Формула изобретения 1. Соединение формулы V R U A 2 0 1 7 1 1 2 9 8 9 A WO 2016/044667 (24.03.2016) 2 0 1 7 1 1 2 9 8 9 (86) Заявка PCT: Стр.: 1 2 0 1 7 1 1 2 9 8 9 R U A Стр.: 2 2 0 1 7 1 1 2 9 8 9 A R U Формула V где (i) R1 обозначает C1-4 алкил (например, метил); (ii) R4 обозначает H, и R2 и R3 независимо обозначают H или C1-4 алкил (например, R2 и R3 оба обозначают метил, или R2 обозначает H, и R3 обозначает изопропил); (iii) R5 присоединен по одному из атомов азота на пиразольной части формулы V и представляет собой фрагмент формулы A 2 0 1 7 1 1 2 9 8 9 R U A Стр.: 3 2 0 1 7 1 1 2 9 8 9 A R U Формула A где X, Y и Z обозначают C, и R8, R9, R11 и R12 обозначают H, и R10 обозначает атом галогена или гетероарил, необязательно замещенный атомом галогена, алкилом, галогеналкилом, гидрокси или карбокси (например, пиридил или 2-галогенпиридил (например, пирид-2-ил, 5-фторпирид-2-ил или 6-фторпирид-2-ил)); и (iv) R6 обозначает H, C1-4алкил, ариламино, необязательно замещенный C1-4алкилом или атомом галогена (например, фениламино или 4-фторфениламино); и (v) n=0; в свободном виде или в виде фармацевтически приемлемой соли. 2. Соединение по п. 1, где R1 обозначает метил. 3. Соединение по любому из пп. 1-2, где R2 и ...

Acid Generator, Sulfonic Acid, Sulfonic Acid Derivatives And Radiation-Sensitive Resin Composition

본 발명은 하기 화학식 1i의 구조를 가진 신규한 감방사선성 산발생제를 제공한다. 이 감방사선성 산발생제를 화학 증폭형 감방사선성 수지 조성물에 사용할 경우, 감방사선성 산발생제는 높은 투명성 및 비교적 높은 가연성을 나타내며 인체 축적성에 문제가 없으며, 발생하는 산의 산성도 및 비점이 높고, 레지스트 피막 중에서의 확산 길이가 적당히 짧으며 마스크 패턴 밀도에 대한 의존성이 낮다. The present invention provides a novel radiation-sensitive acid generator having a structure of Formula 1i. When the radiation-sensitive acid generator is used in a chemically amplified radiation-sensitive resin composition, the radiation-sensitive acid generator has high transparency and relatively high flammability and has no problem in human accumulation, and the acidity and boiling point of acid generated High, the diffusion length in the resist film is moderately short, and the dependence on the mask pattern density is low. <화학식 1i> <Formula 1i> 식 중, R은 불소 함유율이 50 중량％ 이하인 1가의 유기기, 니트로, 시아노기 또는 수소 원자를 나타내고, Z 1 및 Z 2 는 서로 독립적으로 불소 원자 또는 탄소수 1 내지 10의 직쇄상 또는 분지상의 퍼플루오로알킬기를 나타낸다. In the formula, R represents a monovalent organic group, nitro, cyano group or hydrogen atom having a fluorine content of 50% by weight or less, and Z 1 and Z 2 are each independently a fluorine atom or a linear or branched carbon atom having 1 to 10 carbon atoms. Perfluoroalkyl group is represented. 산발생제, 감방사선성 수지 조성물, 알칼리 가용성 수지, 술폰산 Acid generator, radiation sensitive resin composition, alkali soluble resin, sulfonic acid

Photoresist composition, compound and process of producing photoresist pattern

A photoresist composition comprising a resin having an acid-labile group, an acid generator, and a compound represented by formula (I0).

Compounds and methods

FIELD: medicine. SUBSTANCE: invention relates to a PDE1 inhibitor applicable in medicine, characterized by a structure selected from: , , , , , a pharmaceutical composition based thereon for treating and preventing the disease, CNS disorders or injuries. EFFECT: novel effective PDE1 inhibitors with prolonged half-life in vivo are proposed for treating diseases, disorders and injures of the brain and spinal cord. 11 cl, 12 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 711 442 C2 (51) МПК A61K 31/519 (2006.01) C07D 347/00 (2006.01) A61P 25/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61K 31/519 (2019.02); C07D 347/00 (2019.02); A61P 25/00 (2019.02) (21)(22) Заявка: 2017112989, 17.09.2015 (24) Дата начала отсчета срока действия патента: Дата регистрации: 17.01.2020 17.09.2014 US 62/051,735; 18.09.2014 US 62/052,283 (43) Дата публикации заявки: 17.10.2018 Бюл. № 29 (45) Опубликовано: 17.01.2020 Бюл. № 2 (86) Заявка PCT: C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 17.04.2017 US 2015/050814 (17.09.2015) (87) Публикация заявки PCT: WO 2016/044667 (24.03.2016) Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (54) СОЕДИНЕНИЯ И СПОСОБЫ (57) Реферат: Изобретение относится к применимому в медицине ингибитору PDE1, характеризующемуся структурой, выбранной из следующих: R U 2 7 1 1 4 4 2 (56) Список документов, цитированных в отчете о поиске: WO2006133261 A2, 14.12.2006. WO2008063505 A1, 29.05.2008. WO2010098839 A, 02.09.2010. US 20120094966 A1, 19.04.2012. US 20130239234 A1, 12.09.2013. EA 16510 B1, 30.05.2012. 2 7 1 1 4 4 2 (73) Патентообладатель(и): ИНТРА-СЕЛЛУЛАР ТЕРАПИЗ, ИНК. (US) Приоритет(ы): (30) Конвенционный приоритет: R U 17.09.2015 (72) Автор(ы): ЛИ Пэн (US), ЧЖЭН Хайлинь (US), ЧЖАО Цзюнь (US), УЭННОГЛ Лоуренс (US) Стр.: 1 , , , R U 2 7 1 1 4 4 2 C 2 C 2 , 2 7 1 1 4 4 2 фармацевтической композиции на его основе ...

Method for producing triarylorganoborates

Provided herein is a process for preparing triaryl organoborates of the formula 1/n K n+ R 3 4 B − —R 1 (IV), where one equivalent of organoboronic ester of the formula B—R 1 (OR 2 )(OR 3 ) (I) is initially charged together with 1/n equivalents of salt K n+ nX − (II) and 3 equivalents of metal M in a solvent or a solvent mixture S1, 3 equivalents of a haloaromatic R 4 —Y (III) are added, an auxiliary L and optionally a second organic solvent or solvent mixture S2 is added and the compound 1/n K n+ R 3 4 B − —R 1 (IV) is separated off with the organic phase, and to the use of these substances as co-initiator in photopolymer formulations.

Patent RU2017112989A3

ВУ“? 2017112989” АЗ Дата публикации: 23.04.2019 Форма № 18 ИЗПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2017112989/04(022705) 17.09.2015 РСТД52015/050814 17.09.2015 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 62/051,735 17.09.2014 05 2. 62/052,283 18.09.2014 05 Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) СОЕДИНЕНИЯ И СПОСОБЫ Заявитель: ИНТРА-СЕЛЛУЛАР ТЕРАПИЗ, ИНК., ($ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) Аб/1К 31/519 (2006.01) (070 347/00 (2006.01) Аб1Р 25/00 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) Аб1К 31/519 С07О 347/00 Аб1Р 25/00 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): СТРО, СМГРА, РЕРАТБ пе, ОУУРТ, ЕАРАТГУ, Езрасепес, РАТЕМТЗСОРЕ, Раеагсв, КОРТО, 5с1епсе Оиес ОЗРТО, Уапдех, БД ВИНИТИ 6. ДОКУМЕНТЫ, ОТНОСЯЩИЕСЯ К ПРЕДМЕТУ ПОИСКА Кате- Наименование ...

Method for producing triarylorganoborates

The invention relates to a method for producing triarylorganoborates from organoboronic acid esters in the presence of an n-valent cation 1/n K n+ , comprising the anhydrous treatment of the reaction mixture, and to the use of the obtained triarylorganoborates as coinitiators in photopolymer formulations, holographic media and holograms. The claimed method includes providing an alkyl or cycloalkylboronic acid ester of formula B-R'(OR2)(OR3) in an aprotic solvent in the presence of a metal, adding the aryl halide to produce an organometallic compound in situ, adding a ligand for the ion exchange and separation of the produced metal salts and solids (formula (A)). Triarylalkylborates of formulas (C) and (CC) are also claimed.

Novel oxiodinium and thiaiodinium compounds

Novel oxiodinium and thiaiodinium compounds having a superior inhibitory effect against micro-organisms coupled with outstanding stability and low toxicity are described.

Selective oxidation method with enhanced safety

Selective oxidation process with enhanced safety

Selective oxidation process with enhanced safety

Siguran i efikasan postupak za oksidaciju primarnih ili sekundarnih alkohola u odgovarajući aldehid ili keton preko reakcije pomenutog alkohola sa rastvorom anidrida 1,1,1-tri(CZalkanoiloksi-1,1-dihidro-1,2-benzjodoksol 3(1H)on i kompozicija korisna u ovom postupku.

Hypervalent iodine CF2CF2X reagents and their use

A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for fluoroethylation of compounds carrying a reactive group. A preferred compound carrying a reactive group is cystein in any environment such as peptide targets.

Organic trivalent iodine monofluoro transfer reagent compound and synthetic method thereof

本发明涉及一种有机三价碘单氟转移试剂化合物及其合成方法，具体为新型基于环碘酰亚胺骨架的有机三价碘单氟转移试剂2‑乙酰基‑1‑氟‑1,2‑苯碘酰胺‑3(1 H )‑酮化合物，如式（1）所示。本发明有机三价碘单氟转移试剂，其除了具有高价碘试剂的氧化性质外，其在室温条件下对空气以及湿度不敏感，并且有具有很好的溶解性，室温条件下可以很好的溶解于甲苯、二氯甲烷、三氯甲烷、六氟异丙醇等有机溶剂中。本发明具有原料易得，合成方便，产品收率高，应用范围广等诸多优点，并且在反应结束后以高达82%的回收率回收一价碘，符合绿色化学的理念，预期具有很大的应用前景。

Method for manufacturing triaryl organoborate

Selective oxidation process with enhanced safety

Postupak selektivne oksidacije primarnih ili sekundarnih alkohola u odgovarajući aldehid ili keton,naznačen time, što se sastoji od reagiranja spomenutog alkohola s otopinom koja sadrži anhidrid formule (RCO)2O i spoj trialkanoil perjodan formule Igdje R je C2-4 alkil. Patent sadrži još 14 patentnih zahtjeva A process for the selective oxidation of primary or secondary alcohols to the corresponding aldehyde or ketone, comprising reacting said alcohol with a solution containing an anhydride of formula (RCO) 2O and a trialkanoyl periodant compound of formula wherein R is C 2-4 alkyl. The patent contains 14 more patent claims

Onium salt compound, chemically amplified resist composition and patterning process

산확산 억제제로서 작용하는 하기 식 (1)을 갖는 오늄염 및 이러한 산확산 억제제를 포함하는 화학 증폭 레지스트 조성물이 제공된다. 상기 레지스트 조성물은, 리소그래피에 의해 가공되면, 고감도, 및 또한 CDU, LWR 등의 우수한 리소그래피 성능을 나타낸다. An onium salt having the following formula (1) acting as an acid diffusion inhibitor and a chemically amplified resist composition containing this acid diffusion inhibitor are provided. When the resist composition is processed by lithography, it exhibits high sensitivity and also excellent lithography performance such as CDU, LWR and the like.

Novel oxiodinium and thiaiodinium compounds

Novel oxiodinium and thiaiodinium compounds having a superior inhibitory effect against micro-organisms coupled with outstanding stability and low toxicity are described.

A method for functionalization of an aromatic amino acid or a nucleobase

The present invention provides a method for functionalization of an aromatic amino acid or a nucleobase with a fluoroalkyl-containing moiety R_F, wherein the aromatic amino acid is reacted in the presence of at least one reductant with at least one hypervalent iodine fluoroalkyl reagent carrying said floroalkyl-containing moiety R_F.

Compounds and methods

The subject matter generally relates to compounds and methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective agents and/or neural regenerative agents. In a further aspect, the subject matter relates to individuals that are at risk for the development of CNS disease or disorder.

Methods of preservation using pharmaceutical compositions comprising iodolium and bromolium cations

The invention comprises: (i) the hydroxide, (ii) the carbonate, (iii) the propionate, (iv) the butyrate, (v) the cyclopropanecarboxylate, (vi) the tartrate, (vii) the citrate, (viii) the malonate, (ix) the methanesulphonate and (x) the isethionate of the dibenziodolium cation: <PICT:1013571/C2/1> They may be prepared by conventional methods.ALSO:Materials susceptible to damage by contaminating micro-organisms, in particular vaccines, are preserved by adding thereto small quantities (eg. 1 part to 1000-100000 parts by weight) of a salt of the dibenziodolium or dibenzbromolium cation with an acceptable organic or inorganic anion, the said cations having the formulae <FORM:1013571/A5-A6/1> (I) <FORM:1013571/A5-A6/2> (II) Specified vaccines are those containing living bacterial spores eg. those of Bacillus anthracis and killed clostrident vaccines eg. those containing Clostridium botulinum, C. chauvoei, C. oedematiens, C. perfringens (types B, C and D), C. Septicum and C. tetani. The inventions further comprises pharmaceutical bacteriostatic compositions for topical use comprising a carrier and a dibenziodolium or dibenzbromolium salt e.g. in the form of a lotion, cream, jelly, ointment, tincture or eardrops.

Diphenyliodonium hexafluoro metal salts

ABSTRACT OF THE DISCLOSURE Cationic polymerization of a variety of organic materials such as vinyl monomers, prepolymers, cyclic ethers, cyclic esters and organosilicon cyclics can be achieved by the use of certain radiation sensitive aromatic halonium salts. In addition, polymerizable compositions are provided which can be used as coating compounds, molding resins, adhesives etc. The salts have the general formula [(R1) I] + [MF6] -where M is an element selected from the class consisting of P, As and Sb, R1 is a divalent aromatic organic radical selected from and

Selective oxidation process with enhanced safety

SELECTIVE OXIDATION WITH INCREASED SAFETY

A kind of synthetic method of second level trifluoromethyl propargyl ethanol

本发明公开了一种二级三氟甲基炔丙基醇的合成方法，用2‑碘苯甲酸和高碘酸钠反应生成1‑(羟基)‑1,2‑苯碘酰‑3(1H)‑酮(BIOH)，三甲基硅基乙炔和三异丙基氯硅烷生成三甲基硅基(三异丙基硅基)乙炔，BIOH与三甲基硅基(三异丙基硅基)乙炔合成出1‑[(三异丙基硅基)乙炔基]‑1,2‑苯碘酰‑3(1H)‑酮，1‑[(三异丙基硅基)乙炔基]‑1,2‑苯碘酰‑3(1H)‑酮与三氟乙胺盐酸盐、亚硝酸钠反应合成出1‑[(三异丙基硅基)乙炔基]‑1,2‑苯碘酰‑3(1H)‑酮，最后通过水解合成目标产物。本发明所涉及三氟甲基炔丙基醇，是一类重要的含氟砌块分子，对含氟功能有机分子以及医药中间体的合成具有十分重要的意义。

Process for the manufacturing of triaryl-alkyl borates

Novel iodine compounds, processes for their preparation and use thereof as amination agents

The iodine compounds of the present invention corresponds to those of formula (I), wherein R 1 , R 1' and X have several meanings. These iodine compounds gives rise to the amination of several substrates without the need of catalysts, especially metal catalysts, and confer to the amination reaction the further advantage of being performed under mild conditions, which is of interest for industrial-scale production of nitrogenated compounds with pharmaceutical, biological or medicinal applications. Therefore, the iodine compounds of the invention are useful as amination agents. The invention also discloses several processes for the preparation of the iodine compounds of formula (I).

Selective oxidation process with enhanced safety

Method for producing 2-iodosobenzoic acids

本発明は高価な試薬を要せず、比較的安全に、ヨードソ安息香酸類を製造する方法の提供を目的とする。　本発明は、式（I）又は（II）：［式中、Arは、ベンゼン等を示し、R 1 、R 21 及びR 22 は、それぞれ独立して、ハロゲン等を示し、mは、nが0の場合は0-4の整数を、nが1の場合は0、1又は2を示し、nは0又は1を示し、r及びr'は、それぞれ独立して、0、1又を示す。］で表される化合物の製造方法であって式(III)又は(IV)： [式中、Q及びQ'は水素原子、アルカリ金属原子等を示し、x及びx'は2+又は+を示し、y及びzは1又は2を示し、Ar、R 1 、X、R 21 、R 22 、m及びnは前記と同じ。]で表される化合物を、水及び水と有機溶媒との混合溶媒から選択される溶媒中、ペルオキソ一硫酸モノカリウム及びオキソンから選択される少なくとも１つの過硫酸塩の存在下、0℃-100℃で酸化する工程を含む方法に関する。

2-Method for producing iodoso benzoic acid

本発明は高価な試薬を要せず、比較的安全に、ヨードソ安息香酸類を製造する方法の提供を目的とする。本発明は、式（I）又は（II）：［式中、Arは、ベンゼン等を示し、R1、R21及びR22は、それぞれ独立して、ハロゲン等を示し、mは、nが0の場合は0-4の整数を、nが1の場合は0、1又は2を示し、nは0又は1を示し、r及びr’は、それぞれ独立して、0、1又を示す。］で表される化合物の製造方法であって式(III)又は(IV)：[式中、Q及びQ’は水素原子、アルカリ金属原子等を示し、x及びx’は2+又は+を示し、y及びzは1又は2を示し、Ar、R1、X、R21、R22、m及びnは前記と同じ。]で表される化合物を、水及び水と有機溶媒との混合溶媒から選択される溶媒中、ペルオキソ一硫酸モノカリウム及びオキソンから選択される少なくとも１つの過硫酸塩の存在下、0℃-100℃で酸化する工程を含む方法に関する。

Compounds and methods.

La materia objeto generalmente se refiere a compuestos y métodos de tratamiento y/o profilaxis de las enfermedades, trastornos, y/o lesiones del SNC. En un aspecto, la materia objeto se refiere a inhibidores de fosfodiesterasa 1 (PDE1) como agentes neuroprotectores y/o agentes regenerativos neuronales. En un aspecto adicional, la materia objeto se refiere a individuos que están en riesgo para el desarrollo de la enfermedad o trastorno del SNC.

광활성 화합물, 이를 포함하는 포토레지스트 조성물, 및 패턴 형성 방법

유기 양이온 및 화학식 1로 나타낸 음이온을 포함하는 광활성 화합물이 제공된다: [화학식 1] 식 중, X는 유기 기이고; Y 1 및 Y 2 는 각각 독립적으로 비-수소 치환체이고; Y 1 및 Y 2 는 함께 선택적으로 고리를 형성하고; Z 2 는 수소, 할로겐, 치환 또는 비치환된 C 1-30 알킬, 치환 또는 비치환된 C 3-30 시클로알킬, 치환 또는 비치환된 C 3-30 헤테로시클로알킬, 치환 또는 비치환된 C 6-50 아릴, 치환 또는 비치환된 C 7-50 아릴알킬, 치환 또는 비치환된 C 7-50 알킬아릴, 치환 또는 비치환된 C 6-50 아릴옥시, 치환 또는 비치환된 C 3-30 헤테로아릴, 치환 또는 비치환된 C 4-30 알킬헤테로아릴, 치환 또는 비치환된 C 4-30 헤테로아릴알킬, 또는 치환 또는 비치환된 C 3-30 헤테로아릴옥시이고; Z 2 는 그 구조의 일부로서 하나 이상의 2가 연결기를 선택적으로 추가로 포함하고; Z 2 및 Y 1 또는 Y 2 중 하나는 함께 선택적으로 고리를 형성하고; X 및 Z 2 는 함께 선택적으로 고리를 형성하고; X 및 Y 1 또는 Y 2 중 하나는 함께 선택적으로 고리를 형성한다.

Trifluoromethoylation of arenes via intramolecular trifluoromethoxy group migration

The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without substitution; and R 1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl) 2 , —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl); —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:

光活性化合物、それを含むフォトレジスト組成物及びパターン形成方法

【課題】光活性化合物、それを含むフォトレジスト組成物及びパターン形成方法の提供。【解決手段】有機カチオンと、下記式（１）で表されるアニオンとを含む光活性化合物。JPEG2024012132000037.jpg30170（Ｘは有機基であり；Ｙ１及びＹ２は、独立して、水素ではない置換基であり；Ｙ１とＹ２は、一緒に環を形成し；Ｚ２は、水素、ハロゲン、Ｃ１～３０アルキル、Ｃ３～３０シクロアルキル、Ｃ３～３０ヘテロシクロアルキル、Ｃ６～５０アリール、Ｃ７～５０アリールアルキル、Ｃ７～５０アルキルアリール、Ｃ６～５０アリールオキシ、Ｃ３～３０ヘテロアリール、Ｃ４～３０アルキルヘテロアリール、Ｃ４～３０ヘテロアリールアルキル、又はＣ３～３０ヘテロアリールオキシであり；Ｚ２は、その構造の一部として１つ以上の二価連結基を更に含み；Ｚ２とＹ１又はＹ２のうちの一方は、一緒に環を形成し；ＸとＺ２は、一緒に環を形成し；ＸとＹ１又はＹ２のうちの一方は、一緒に環を形成する）【選択図】なし

一种芳基乙烯基环状高价碘化合物及其制备方法与应用

本发明属于生物医药技术领域，具体涉及一种芳基乙烯基环状高价碘化合物及其制备方法与应用。该化合物结构新颖稳定，并且具有显著的抗肿瘤细胞效果，特别是对A549、DLD‑1、PANC‑1肿瘤细胞的IC50较低，抗肿瘤细胞效果显著，在抗肿瘤治疗方面具有较好的应用前景。另外的，所述芳基乙烯基环状高价碘化合物的制备方法简单易行，可以进行大规模产业化生产，为抗肿瘤的医学研究和临床应用提供了更多的药物选择。

광산 발생제, 포토레지스트 조성물, 및 패턴 형성 방법

유기 양이온; 및 음이온성 코어를 포함하는 음이온을 포함하고, 상기 음이온성 코어는 시클로펜타디에나이드 기를 포함하고, 상기 시클로펜타디에나이드 기는 반-금속 원소를 포함하는 유기 기로 치환되고, 상기 음이온은 하나 이상의 전자 끌기 기로 치환되는, 광산 발생제가 본원에 제공된다.

1‑羟基‑1,2‑苯碘酰‑3(1h)‑酮的制备方法

本发明涉及一种1‑羟基‑1,2‑苯碘酰‑3(1H)‑酮的制备方法，在250mL圆底烧瓶中依次加入邻碘苯甲酸，高碘酸钠，冰醋酸，搅拌使邻碘苯甲酸完全溶解，进行回流；冷凝管由下至上通冷凝水(25℃)后，将圆底烧瓶置于120℃油浴锅中磁力搅拌，在避光下反应4小时。反应结束后静止冷却至室温，加入蒸馏水，过滤，收集粗产物，用冰水和丙酮洗涤三次，放在黑暗处晾干得到白色1‑羟基‑1,2‑苯碘酰‑3(1H)‑酮产品。本发明反应条件温和、工艺过程简单，选择性高、产率93％，产率较高；对环境友好，本发明制备的产品可以应用到有机合成等领域。

Compostos inibidores de fosfodiesterase 1 (pde1), composição farmacêutica que compreende os ditos compostos e usos dos mesmos no tratamento de uma doença, distúrbio, e/ou lesão do snc e no tratamento e/ou na profilaxia de uma doença, distúrbio e/ou lesão do snp

compostos e métodos. a presente invenção refere-se, de modo geral, a compostos e métodos de tratamento e/ou profilaxia de doenças, distúrbios e/ou lesões do cns. em um aspecto, o campo se refere a inibidores de fosfodiesterase 1 (pde1) como agentes neuroprotetores e/ou agentes regenerativos neurais. em um outro aspecto, o assunto refere-se a indivíduos que estão em risco de desenvolvimento de doença ou distúrbio do cns.

Condensed cyclic compound and organic light-emitting device including the same

An organic light-emitting device includes: a first electrode; a second electrode facing the first electrode; an organic layer between the first electrode and the second electrode and comprising an emission layer; and at least one condensed cyclic compound represented by Formula 1-1, 1-2, or 1-3:where in Formulae 1-1 to 1-3, at least one of R1(s) is an electron withdrawing group, at least one selected from R2(s) and R3(s) is an electron withdrawing group, and at least one selected from R4(s), R5(s), and R6(s) is an electron withdrawing group, wherein a case where the number of cyano groups in the electron withdrawing group included in the condensed cyclic compound represented by Formula 1-1 is two or more is excluded.

Compounds and methods

The subject matter of the present application generally relates to compounds, compositions and methods of treatment and/or prophylaxis of CNS and PNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) having the structure of Formula V and to their use as neuroprotective agents and/or neural regenerafive agents. (see formula V) In a further aspect, the subject matter of this application relates to treatment of individuals that are at risk for the development of CNS disease or disorder.

光酸発生剤、フォトレジスト組成物及びパターン形成方法

【課題】 光酸発生剤、フォトレジスト組成物及びパターン形成方法を提供する。【解決手段】 有機カチオンと、シクロペンタジエニド基を含むアニオン性コアを含むアニオンとを含む光酸発生剤であって、シクロペンタジエニド基は、半金属元素を含む有機基で置換されており、アニオンは、１つ又は複数の電子吸引基で置換されている、光酸発生剤。

Εκλεκτικη διαδικασια οξειδωσης με ενισχυμενη ασφαλεια

Μια ασφαλής και αποτελεσματική διαδικασία για την οξείδωση μιας πρωτοταγούς ή δευτεροταγούς αλκοόλης στην αντίστοιχη αλδεΰδη ή κετόνη μέσω της αντίδρασης της αναφερθείσας αλκοόλης με ένα διάλυμα ανυδρίτη από μια 1,1,1-τρι(CZ-C4αλκανοϋλοξυ-1,1-διϋδρο-1,2-βενζιοδοξολ 3(1Η)–όνη και μια σύνθεση χρήσιμη σε αυτή τη διαδικασία.

Selektive oxidation mit erhöhter sicherheit

光酸產生劑、光阻劑組成物及圖案形成方法

一種光酸產生劑，其包括有機陽離子；和包括陰離子核的陰離子，其中陰離子核包括環戊二烯化基團，其中環戊二烯化基團被包括半金屬元素的有機基團取代，並且其中陰離子被一個或多個吸電子基團取代。

Photoacid generators, photoresist compositions, and pattern formation methods

A photoacid generator, including an organic cation; and an anion including an anionic core, wherein the anionic core includes a cyclopentadienide group, wherein the cyclopentadienide group is substituted with an organic group including a semi-metal element, and wherein the anion is substituted with one or more electron withdrawing groups.

Photoactive compounds, photoresist compositions including the same, and pattern formation methods

A photoactive compound including an organic cation; and an anion represented by Formula (1):wherein X is an organic group; Y1 and Y2 are each independently a non-hydrogen substituent; Y1 and Y2 together optionally form a ring; Z2 is hydrogen, halogen, substituted or unsubstituted C1-30 alkyl, substituted or unsubstituted C3-30 cycloalkyl, substituted or unsubstituted C3-30 heterocycloalkyl, substituted or unsubstituted C6-50 aryl, substituted or unsubstituted C7-50 arylalkyl, substituted or unsubstituted C7-50 alkylaryl, substituted or unsubstituted C6-50 aryloxy, substituted or unsubstituted C3-30 heteroaryl, substituted or unsubstituted C4-30 alkylheteroaryl, substituted or unsubstituted C4-30 heteroarylalkyl, or substituted or unsubstituted C3-30 heteroaryloxy; Z2 optionally further comprises one or more divalent linking groups as part of its structure; Z2 and one of Y1 or Y2 together optionally form a ring; X and Z2 together optionally form a ring; and X and one of Y1 or Y2 together optionally form a ring.

２－ヨードソ安息香酸類の製造方法

Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (CSCs) by inhibiting mitochondrial respiration

The present disclosure relates to compounds that bind to flavin-containing enzymes and inhibit mitochondrial function, referred to herein as mitoflavoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoflavoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitoflavoscins to provide anti-aging benefits. Specific mitoflavoscin compounds are also disclosed.

フッ化化合物

光活性化合物、包含其之光阻劑組成物及圖案形成方法

公開了一種光活性化合物，其包含有機陽離子；和由式 (1) 表示的陰離子： 其中X係有機基團；Y 1 和Y 2 各自獨立地是非氫取代基；Y 1 和Y 2 一起視需要形成環；Z 2 係氫、鹵素、取代或未取代的C 1-30 烷基、取代或未取代的C 3-30 環烷基、取代或未取代的C 3-30 雜環烷基、取代或未取代的C 6-50 芳基、取代或未取代的C 7-50 芳基烷基、取代或未取代的C 7-50 烷基芳基、取代或未取代的C 6-50 芳氧基、取代或未取代的C 3-30 雜芳基、取代或未取代的C 4-30 烷基雜芳基、取代或未取代的C 4-30 雜芳基烷基、或取代或未取代的C 3-30 雜芳氧基；Z 2 視需要進一步包含作為其結構的一部分的一個或多個二價連接基團；Z 2 和Y 1 或Y 2 中的一個一起視需要形成環；X和Z 2 一起視需要形成環；並且X和Y 1 或Y 2 中的一個一起視需要形成環。

环保的烯烃水合反应

本发明提供了用于合成有机叠氮化物的方法、用于其生产的中间体以及与之相关的组合物。

Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (cscs) by inhibiting mitochondrial respiration

The present disclosure relates to compounds that bind to flavin-containing enzymes and inhibit mitochondrial function, referred to herein as mitoflavoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoflavoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitoflavoscins to provide anti-aging benefits. Specific mitoflavoscin compounds are also disclosed.

光活性化合物、包含其的光致抗蚀剂组合物及图案形成方法

公开了一种光活性化合物，其包含有机阳离子；和由式(1)表示的阴离子：其中X是有机基团；Y 1 和Y 2 各自独立地是非氢取代基；Y 1 和Y 2 一起任选地形成环；Z 2 是氢、卤素、取代或未取代的C 1‑30 烷基、取代或未取代的C 3‑30 环烷基、取代或未取代的C 3‑30 杂环烷基、取代或未取代的C 6‑50 芳基、取代或未取代的C 7‑50 芳基烷基、取代或未取代的C 7‑50 烷基芳基、取代或未取代的C 6‑50 芳氧基、取代或未取代的C 3‑30 杂芳基、取代或未取代的C 4‑30 烷基杂芳基、取代或未取代的C 4‑30 杂芳基烷基、或取代或未取代的C 3‑30 杂芳氧基；Z 2 任选地进一步包含作为其结构的一部分的一个或多个二价连接基团；Z 2 和Y 1 或Y 2 中的一个一起任选地形成环；X和Z 2 一起任选地形成环；并且X和Y 1 或Y 2 中的一个一起任选地形成环。

Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without subsutitution; and R 1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl) 7 , —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:

Condensed cyclic compound and organic light-emitting device including the same

An organic light-emitting device includes: a first electrode; a second electrode facing the first electrode; an organic layer between the first electrode and the second electrode and comprising an emission layer; and at least one condensed cyclic compound represented by Formula 1-1, 1-2, or 1-3: where in Formulae 1-1 to 1-3, at least one of R 1 (s) is an electron withdrawing group, at least one selected from R 2 (s) and R 3 (s) is an electron withdrawing group, and at least one selected from R 4 (s), R 5 (s), and R 6 (s) is an electron withdrawing group, wherein a case where the number of cyano groups in the electron withdrawing group included in the condensed cyclic compound represented by Formula 1-1 is two or more is excluded.

화합물, 감활성 광선성 또는 감방사선성 수지 조성물, 그것을 이용한 레지스트막, 레지스트 도포 마스크 블랭크스, 포토마스크 및 패턴 형성 방법, 그리고 전자 디바이스의 제조 방법 및 전자 디바이스

(A) 하기 일반식 (I) 또는 (II)로 나타나는 화합물을 함유하는 감활성 광선성 또는 감방사선성 수지 조성물에 의하여, 극미세(예를 들면, 선폭 50nm 이하)의 패턴을, 고감도 및 고해상성(예를 들면, 높은 해상력), 우수한 패턴 형상 및 작은 라인 에지 러프니스(LER)를 동시에 만족한 상태로 형성할 수 있는 화합물 및 감활성 광선성 또는 감방사선성 수지 조성물을 제공한다. [화학식 1] [화학식 2] (식 중, Y 1 및 Y 2 는 1가의 유기기를 나타낸다. M 1 + 및 M 2 + 는 유기 오늄 이온을 나타낸다. X 1 및 X 2 는 -S-, -NH- 또는 -NR 1 -로 나타나는 기를 나타낸다. R 1 은 1가의 유기기를 나타낸다. n1 및 n2는 1 이상의 정수를 나타낸다. R 1 과 Y 1 또는 Y 2 가 서로 결합하여 환을 형성해도 된다.)

Environmentally-friendly hydroazidation of olefins

Diazomethylation reagent and process for using it

Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (cscs) by inhibiting mitochondrial respiration

The present disclosure relates to compounds that bind to flavin-containing enzymes and inhibit mitochondrial function, referred to herein as mitoflavoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoflavoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitoflavoscins to provide anti-aging benefits. Specific mitoflavoscin compounds are also disclosed.

Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (cscs) by inhibiting mitochondrial respiration

Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (cscs) by inhibiting mitochondrial respiration

一种光致产酸剂及其制备方法、光刻胶

本申请适用于光刻胶领域，具体公开一种光致产酸剂及其制备方法、以及应用该光致产酸剂的光刻胶。本申请的光致产酸剂可控制光酸的扩散距离以及光酸产生的扩散系数，从而控制光刻胶形貌的边缘粗糙度，提高光刻胶的分辨率；同时该光致产酸剂还可以避免曝光不足的问题。

Hypervalent radioactive astatine or iodine compounds, and preparation methods thereof

The present invention relates to a compound having formula (I): wherein: - X is in particular 125 I Or 211 At; - R 1 and R' 1 are independently from each other chosen preferably from the group consisting of electron-withdrawing groups and alkyl groups; - R 2 is chosen from the group consisting of : H, alkyl groups, functional groups being able to bind a vector, and functional groups having targeting properties which make the compound of the invention a vector itself; - Z is a heteroatom, - R 5 , R 8 and R 9 are preferably H; - Y is preferably an electron withdrawing group.

Reactivo de diazometilación y procedimiento para su uso

Un compuesto de formula (I) **(Ver fórmula)** donde: la línea de puntos significa que R1 está unido al átomo de yodo a través de un enlace seleccionado entre un enlace covalente y un enlace iónico, E es un radical seleccionado del grupo que consiste en el radical de fórmula -G1, y el radical de fórmula -G2-G3 donde: G1 y G3 se seleccionan independientemente del grupo que consiste en (C1-C6)haloalquilo, (C1-C6)alquiloxicarbonilo, benciloxicarbonilo, un grupo formilo (-CHO), alquilcarbonilo (C1-C6), carboxilo (-COOH), un radical de fórmula - CONRaRb en la que Ra y Rb se seleccionan cada uno independientemente del grupo formado por hidrógeno y (C1- C6)alquilo, halógeno, nitro, (C1-C6)alquiloxisulfonilo, un radical de fórmula -P(O)(O(C1-C6)alquilo)2, nitrilo y un sistema de anillo aromático que comprende de 1 a 2 anillos aromáticos de 6 miembros, donde los miembros están seleccionados del grupo que consiste en C, CH y N, siendo al menos un miembro N, y los anillos son además opcionalmente sustituidos en cualquier posición disponible con uno o más grupos seleccionados de halógeno, (C1- C6)alquilo, (C1-C6)haloalquilo, (C1-C6)alquiloxi, (C1-C6)alquilcarbonilo, (C1-C6)alquilcarboniloxi, (C1- C6)alquiloxicarbonilo, nitrilo, un grupo formilo y nitro; y G2 es un dirradical seleccionado del grupo que consiste en vinilo (-CH = CH-), carbonilo y un sistema de anillo aromático que comprende de 1 a 2 anillos aromáticos de 5 a 6 miembros, seleccionándose los miembros del grupo que consiste en C, CH, O, S y N, y donde tanto el vinilo como el sistema de anillo aromático están además opcionalmente sustituidos en cualquier posición disponible con uno o más grupos seleccionados entre halógeno, (C1- C6)alquilo, (C1-C6)haloalquilo, (C1-C6)alquiloxi, (C1-C6)alquilcarbonilo, (C1-C6)alquilcarboniloxi, (C1- C6)alquiloxicarbonilo, nitrilo, un grupo formilo y nitro; R1 es seleccionado del grupo constituido por halo, (C1-C6)haloalquilsulfoniloxi, (C1-C6)alquilsulfoniloxi, fenilsulfoniloxi, ...

Diazomethylation reagent and process for using it

The present invention relates compounds useful as reagents for the diazomethylation reaction, their preparation and the use thereof as reagents in a method for the diazomethylation reaction of aromatic substrates. It relates in particular to a compound of formula (I) wherein E is an electron withdrawing group.

Diazomethylation reagent and process for using it

The present invention relates compounds useful as reagents for the diazomethylation reaction, their preparation and the use thereof as reagents in a method for the diazomethylation reaction of aromatic substrates. It relates in particular to a compound of formula (I) wherein E is an electron withdrawing group.

オニウム塩化合物、化学増幅レジスト組成物及びパターン形成方法

Hypervalent radioactive astatine or iodine compounds, and preparation methods thereof

The present invention relates to a compound having formula (I): wherein: - X is in particular 125 I Or 211 At; - R 1 and R' 1 are independently from each other chosen preferably from the group consisting of electron-withdrawing groups and alkyl groups; - R 2 is chosen from the group consisting of : H, alkyl groups, functional groups being able to bind a vector, and functional groups having targeting properties which make the compound of the invention a vector itself; - Z is a heteroatom, - R 5 , R 8 and R 9 are preferably H; - Y is preferably an electron withdrawing group.

环保的烯烃水合反应

本发明提供了用于合成有机叠氮化物的方法、用于其生产的中间体以及与之相关的组合物。

1‑苯基乙炔基‑1,2‑苯碘酰‑3‑酮的制备方法

本发明涉及一种1‑苯基乙炔基‑1,2‑苯碘酰‑3‑酮的制备方法，反应管中加1‑羟基‑1,2‑苯碘酰‑3(1H)‑酮、二氯甲烷溶解，加5号磁子一个。反应管置于油浴锅中加热反应，加三氟甲磺酸三甲基硅酯反应1小时，逐滴加入苯基乙炔基三甲基硅烷室温下反应4小时，加入饱和的碳酸氢钠溶液，加大搅拌速度继续反应0.5h，反应液倒入分液漏斗中，加乙酸乙酯，用饱和碳酸氢钠溶液洗涤三次，收集有机相后经减压蒸馏得粗产品，再用乙腈进行重结晶得浅黄色1‑苯基乙炔基‑1,2‑苯碘酰‑3‑酮固体。本发明反应条件温和、工艺过程简单及对环境友好等优点；产品可以作为氧化剂和反应物应用到有机合成等领域。

一种二级三氟甲基炔丙基醇的合成方法

本发明公开了一种二级三氟甲基炔丙基醇的合成方法，用2‑碘苯甲酸和高碘酸钠反应生成1‑(羟基)‑1,2‑苯碘酰‑3(1H)‑酮(BIOH)，三甲基硅基乙炔和三异丙基氯硅烷生成三甲基硅基(三异丙基硅基)乙炔，BIOH与三甲基硅基(三异丙基硅基)乙炔合成出1‑[(三异丙基硅基)乙炔基]‑1,2‑苯碘酰‑3(1H)‑酮，1‑[(三异丙基硅基)乙炔基]‑1,2‑苯碘酰‑3(1H)‑酮与三氟乙胺盐酸盐、亚硝酸钠反应合成出1‑[(三异丙基硅基)乙炔基]‑1,2‑苯碘酰‑3(1H)‑酮，最后通过水解合成目标产物。本发明所涉及三氟甲基炔丙基醇，是一类重要的含氟砌块分子，对含氟功能有机分子以及医药中间体的合成具有十分重要的意义。

氧化剂ibx的制备方法

本发明公开了一种2‑碘酰基苯甲酸的制备方法。以2‑碘苯甲酸、过硫酸氢钾等为原料，经过一步反应得到目的产物2‑碘酰基苯甲酸。本发明工艺操作简便稳定，产物容易分离、收率高，产品纯度99.5％以上。且原料价廉易得，大幅降低了现有生物、医药、化学中间体的生产成本，有利于工业化规模生产。

Mitoflavoscinas: la fijacion como objetivo de enzimas que contienen flavina elimina celulas madre cancerosas (cscs) al inhibir la respiracion mitocondrial.

La presente descripción se refiere a compuestos que se enlazan a enzimas que contienen flavina e inhiben la función mitocondrial, referidos en este documento como mitoflavoscinas. Se describen métodos para examinar compuestos por la inhibición mitocondrial y propiedades anticancerosas. También se describen métodos para usar mitoflavoscinas para prevenir o tratar el cáncer, infecciones bacterianas y levadura patógena, así como también métodos para usar mitoflavoscinas para proporcionar beneficios anti-envejecimiento. También se dan a conocer compuestos específicos de mitoflavoscina.

Method for producing triarylorganoborates

The invention relates to a process for preparing triaryl organo borates proceeding from organoboronic esters in the presence of an n-valent cation 1/n K n+ , comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms.

Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (cscs) by inhibiting mitochondrial respiration

The present disclosure relates to compounds that bind to flavin-containing enzymes and inhibit mitochondrial function, referred to herein as mitoflavoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoflavoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitoflavoscins to provide anti-aging benefits. Specific mitoflavoscin compounds are also disclosed.

一种亲电三氟甲硫基试剂、合成方法及其应用

本发明涉及一种亲电三氟甲硫基化试剂、合成方法及其应用。该试剂具有如下的结构式：

杂原子桥接的六元环状二芳基碘盐化合物及其应用

本发明公开了一种杂原子桥接的六元环状二芳基碘盐化合物，结构选自以下结构中的一种： 本发明方法原料简单易得，反应条件温和，底物适应性强，可用于合成多种杂原子桥接的六元环状二芳基碘盐化合物。该方法首先设计合成了两类邻位功能化的二芳基碘盐，随后经三步一锅法高效制备六元环状O桥接杂环二芳基碘盐和N桥接杂环二芳基碘盐。该方法将香豆素骨架加入环状碘盐中，通过紫外可见吸收实验证明该类化合物在光化学中的潜在应用。该方法还对其中氧原子桥接的环状碘盐进行抗菌实验测定，证明该类碘盐是一种应用前景光明的新型高效敏感抗菌剂。

光酸产生剂、光致抗蚀剂组合物及图案形成方法

一种光酸产生剂，其包括有机阳离子；和包括阴离子核的阴离子，其中阴离子核包括环戊二烯化基团，其中环戊二烯化基团被包括半金属元素的有机基团取代，并且其中阴离子被一个或多个吸电子基团取代。

光活性化合物、包含其的光致抗蚀剂组合物及图案形成方法

公开了一种光活性化合物，其包含有机阳离子；和由式(1)表示的阴离子：其中X是有机基团；Y 1 和Y 2 各自独立地是非氢取代基；Y 1 和Y 2 一起任选地形成环；Z 2 是氢、卤素、取代或未取代的C 1‑30 烷基、取代或未取代的C 3‑30 环烷基、取代或未取代的C 3‑30 杂环烷基、取代或未取代的C 6‑50 芳基、取代或未取代的C 7‑50 芳基烷基、取代或未取代的C 7‑50 烷基芳基、取代或未取代的C 6‑50 芳氧基、取代或未取代的C 3‑30 杂芳基、取代或未取代的C 4‑30 烷基杂芳基、取代或未取代的C 4‑30 杂芳基烷基、或取代或未取代的C 3‑30 杂芳氧基；Z 2 任选地进一步包含作为其结构的一部分的一个或多个二价连接基团；Z 2 和Y 1 或Y 2 中的一个一起任选地形成环；X和Z 2 一起任选地形成环；并且X和Y 1 或Y 2 中的一个一起任选地形成环。

一种芳基乙烯基环状高价碘化合物及其制备方法与应用

本发明属于生物医药技术领域，具体涉及一种芳基乙烯基环状高价碘化合物及其制备方法与应用。该化合物结构新颖稳定，并且具有显著的抗肿瘤细胞效果，特别是对A549、DLD‑1、PANC‑1肿瘤细胞的IC50较低，抗肿瘤细胞效果显著，在抗肿瘤治疗方面具有较好的应用前景。另外的，所述芳基乙烯基环状高价碘化合物的制备方法简单易行，可以进行大规模产业化生产，为抗肿瘤的医学研究和临床应用提供了更多的药物选择。

一种光致产酸剂及其制备方法、光刻胶

本申请适用于光刻胶领域，具体公开一种光致产酸剂及其制备方法、以及应用该光致产酸剂的光刻胶。本申请的光致产酸剂可控制光酸的扩散距离以及光酸产生的扩散系数，从而控制光刻胶形貌的边缘粗糙度，提高光刻胶的分辨率；同时该光致产酸剂还可以避免曝光不足的问题。

杂原子桥接的六元环状二芳基碘盐化合物及其应用

本发明公开了一种杂原子桥接的六元环状二芳基碘盐化合物，结构选自以下结构中的一种： 本发明方法原料简单易得，反应条件温和，底物适应性强，可用于合成多种杂原子桥接的六元环状二芳基碘盐化合物。该方法首先设计合成了两类邻位功能化的二芳基碘盐，随后经三步一锅法高效制备六元环状O桥接杂环二芳基碘盐和N桥接杂环二芳基碘盐。该方法将香豆素骨架加入环状碘盐中，通过紫外可见吸收实验证明该类化合物在光化学中的潜在应用。该方法还对其中氧原子桥接的环状碘盐进行抗菌实验测定，证明该类碘盐是一种应用前景光明的新型高效敏感抗菌剂。

二亚苯基碘鎓氯化物用于类风湿关节炎模型造模的用途、类风湿关节炎模型造模方法

本发明公开了二亚苯基碘鎓氯化物用于类风湿关节炎模型造模的用途、类风湿关节炎模型造模方法。本发明发现，二亚苯基碘鎓氯化物可以有效提高类风湿关节炎模型的诱导效率，Ⅱ型胶原诱导1次结合二亚苯基碘鎓氯化物增强对模型鼠的类风湿关节炎的诱导效率显著优于传统Ⅱ型胶原诱导多次。本领域技术人员知道，二亚苯基碘鎓氯化物NADPH氧化酶的抑制剂，可以通过抑制电子传递和活性氧产生发挥抗炎作用。而在本发明中，二亚苯基碘鎓氯化物发挥的作用是强化类风湿关节炎，这种技术效果是让本领域技术人员意料不到的。

一种重氮二氟甲基化试剂及其合成方法和应用

本发明属于有机化工及药物合成领域，具体涉及一种新型重氮二氟甲基化试剂及其合成方法和应用。将重氮高价碘试剂与三甲硅基三氟甲磺酸酮、(2‑重氮‑1,1‑二氟乙基)‑磺酰基苯Ps‑DFA，室温下发生反应，得到一系列重氮二氟甲基化试剂衍生物，可作为重氮二氟甲基自由基广泛应用于各类亲核反应中，向有机分子中引入二氟甲基结构单元。本反应在室温条件下，反应3‑5小时，即可得到一系列重氮二氟甲基化试剂衍生物，产率为60％‑80％，为重氮二氟甲基化试剂作为含氟切块提供了一种简便高效的新方法。

一种固体超强酸催化制备戴斯马丁试剂的工艺

本发明涉及有机合成技术领域，具体公开了一种固体超强酸催化制备戴斯马丁试剂的工艺，包括如下步骤：S1、氧化反应：将溴酸钾和自来水混合，加入固体超强酸HERD‑Cat‑1，搅拌升温至40℃～90℃；分批加入邻碘苯甲酸，加完后在此温度下反应1h～8h，冷却后离心水洗、有机溶剂洗，得IBX湿品；S2、乙酰化反应：将IBX湿品加入到有机溶剂中，溶解过滤回收固体超强酸HERD‑Cat‑1，再分别加入催化剂和乙酸酐，升温至40‑80℃反应，冷却结晶，离心烘干得戴斯马丁试剂；本发明使用固体超强酸催化后避免了大量废酸的产生，同时IBX纯度高。该工艺具有反应步骤短、化学纯度高、操作简单、成本低廉、生产安全性高、对环境友好等优点，适宜工业化生产。

鎓盐化合物、化学增幅抗蚀剂组成物、以及图案形成方法

本发明涉及鎓盐化合物、化学增幅抗蚀剂组成物、以及图案形成方法。本发明的课题是提供在以KrF准分子激光、ArF准分子激光、电子束、极紫外线等高能量射线作为光源的光学光刻中，为高感度，且CDU、LWR等光刻性能优异的化学增幅抗蚀剂组成物；并提供其所使用的酸扩散抑制剂、及使用该化学增幅抗蚀剂组成物的图案形成方法。该课题的解决手段为下式(1)表示的鎓盐化合物、由该鎓盐化合物构成的酸扩散抑制剂、及含有该酸扩散抑制剂的化学增幅抗蚀剂组成物。

环保的烯烃水合反应

本发明提供了用于合成有机叠氮化物的方法、用于其生产的中间体以及与之相关的组合物。