УСТРОЙСТВО УМЕНЬШЕНИЯ ПОГРЕШНОСТИ ЧУВСТВИТЕЛЬНОСТИ ПО ДАВЛЕНИЮ И ТЕМПЕРАТУРЕ У ВЫСОКОТОЧНЫХ ОПТИЧЕСКИХ ИЗМЕРИТЕЛЬНЫХ ПРЕОБРАЗОВАТЕЛЕЙ ПЕРЕМЕЩЕНИЯ

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Полезная модель относится к медицинской аналитической технике и может быть использована для одновременного определения концентрации общего гемоглобина крови и ряда его фракций по оптической плотности в диапазоне длин волн 450-650 нм. Оптический узел содержит оптически сопряженные между собой и последовательно установленные на одной оптической оси следующие оптические элементы (фиг. 1): светодиодный осветитель 1, первую линзу 2, вторую линзу 3, щель 4, третью линзу 5, дифракционную решетку 6, четвертую линзу 7 и линейку 8 фотоприемников. Оптические элементы расположены внутри корпуса (фиг. 2 и фиг. 3), выполненного в виде сопрягаемых верхней части 9 и нижней части 10 корпуса и боковой стенки 11. На внутренних поверхностях верхней и нижней частей 9, 10 корпуса выполнены сопрягаемые между собой посадочные места в виде углублений для оптических элементов узла спектрофотометра. Дифракционная решетка закреплена на боковой стенке 11, установленной под углом 31° относительно оптической оси узла ...

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ВХОДНОЙ КАНАЛ ДЕТЕКТОРА И СПОСОБ ВЗЯТИЯ ПРОБ

Способ для неинвазивного оптического мониторинга патологии тканей жизненно важных органов при сахарном диабете и биосенсор для его реализации

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НАГРЕВАТЕЛЬНОЕ УСТРОЙСТВО ДЛЯ ПРИБОРА ДЛЯ ИЗМЕРЕНИЯ МЕТОДОМ СПЕКТРОМЕТРИИ

СИСТЕМА ИЗМЕРЕНИЯ ГАЗА

ФОТОЭЛЕКТРИЧЕСКИЙ ДАТЧИК ДЫМА

... 1. Фотоэлектрический датчик дыма, который обнаруживает дым, текущий в корпус, посредством света, содержащий:светоизлучающий элемент, выполненный обращенным к области обнаружения в корпусе и излучающий контрольный свет к области обнаружения;светопринимающий элемент, предусмотренный в положении, сдвинутом от оптического пути контрольного света светоизлучающего элемента посредством обращения к области обнаружения, и принимающий рассеянный свет, который представляет собой контрольный свет, попадающий в дым и рассеивающийся, чтобы обнаруживать дым; иотражающий элемент, предусмотренный в корпусе и отклоняющий и отражающий контрольный свет, излучаемый из светоизлучающего элемента, чтобы он не входил в светопринимающий элемент.2. Фотоэлектрический датчик дыма по п. 1, в котором отражающий элемент предусмотрен в положении, противоположном светоизлучающему элементу и светопринимающему элементу, при этом охватывая область обнаружения и отражая контрольный свет из светоизлучающего элемента в направлении ...

Messraum zur Aufnahme eines eine Sensoreinheit umfassenden Messsystems

Messraum zur Aufnahme eines eine Sensoreinheit umfassenden Messsystems, welcher ein umgebungslichtdurchlässiges Trennelement (2) aufweist, wobei die Sensoreinheit (4) zur Aussendung von Infrarotlicht und zum Empfang von dem von einem Empfänger (7) oder von mehreren Empfängern reflektierten Infrarotlicht ausgebildet ist, dadurch gekennzeichnet, dass das umgebungslichtdurchlässige Trennelement (2) zumindest teilweise mit einer Infrarotlicht-reflektierenden Partikel aufweisenden Folie (8) belegt ist.

VORRICHTUNG UND VERFAHREN ZUR ERZEUGUNG VON AEROSOLEN FÜR ARZNEIMITTELVERABREICHUNG

Gerüststruktur zum Zusammenwirken mit einer Bildauswertevorrichtung für zumindest einen mindestens eine optochemische Detektierfläche aufweisenden Träger

Die Erfindung betrifft eine Gerüststruktur (10) zum Zusammenwirken mit einer Bildauswertevorrichtung (12) für zumindest einen mindestens eine optochemische Detektierfläche (14) aufweisenden Träger (16) mit einer ersten Wandkomponente (10a) der Gerüststruktur (10), an welcher eine erste Markierung zumindest eine Soll-Position des Trägers (16) anzeigt, und einer zweiten Wandkomponente (10b) der Gerüststruktur (10), an welcher eine zweite Markierung eine Soll-Platzierposition der Bildauswertevorrichtung (12) bezüglich der Gerüststruktur (10) derart anzeigt, dass die mindestens eine optochemische Detektierfläche (14) des Trägers (16) in einem Sichtfeld (18) der Bildauswertevorrichtung (12) und in einem durch die Gerüststruktur (10) fest vorgegebenen Abstand zu der Bildauswertevorrichtung (12) angeordnet ist. Ebenso betrifft die Erfindung eine Bildauswertevorrichtung (12) zum Zusammenwirken mit der Gerüststruktur (10), ein Auswertesystem für zumindest einen mindestens eine optochemische Detektierfläche ...

Wechselbares Prozessfenster

Es wird ein Prozessfenster für die spektroskopische Untersuchung von Prozessgemischen beschrieben. Das Prozessfenster besteht aus einer Fensterfassung (11) zur Aufnahme eines Fensters (2), einem Schraubzylinder (12), mit einem Strahlungsdurchgang (13) in seinem Kern und einem Außengewinde (14) zum Einschrauben des Schraubzylinders (12) in die Fensterfassung (11) sowie einem elastischen Dichtmittel (3) zwischen Fenster (2) und Schraubzylinder (12), wobei das Fenster (2) zu der dem Schraubzylinder (12) entgegengesetzten Prozessseite konisch verjüngend zulaufend ausgeführt ist.

Improvements in and relating to reaction vessels for use with such vessels

Sample holder for use at Cryogenic and elevated temperatures

A shadow-creating apparatus

An apparatus (12) or accurately locating a micro-electronic chip (9) in a chip-holding cavity (28) for visual testing, the chip (9) having at least a front wall and a pair of opposed, spaced-apart side walls, wherein the front wall meets with each of the side walls to form opposed, spaced-apart first and second front edges, comprising a cavity side wall formed to juxtapositionally about at least one of the side walls of the chip, the cavity side wall having formed therein a depression creating a shadow projecting forward from the depression, wherein the first front edge of the chip (9) forms a border of the shadow to form an objectively measurable contrast in grayness between the shadow and the chip (9).

Microtitre plate with heating means to prevent condensation

A reaction vessel 10, typically a microtitre vessel, incorporating heating means 13 for effecting the reaction and having a lid 20 with a window 22 to enable viewing of the contents of the vessel. The arrangement being such that the heating means also operates to ensure that the window is kept vapour-free. Apparatus within which such reaction vessels are stationed during the reaction has an array of thermopile sensors 52 for measuring vessel temperature.

METHOD AND APPARATUS FOR DETECTING PARTICLES ON A MATERIAL

Automated postflight troubleshooting sensor array

Measurement of reinforcement volume fraction

A method is provided for measuring the volume fraction of reinforcement 5 in a composite material 4 in which a translucent polymer matrix is reinforced by the reinforcement (carbon or glass fibre).. The method includes providing a measuring device having a light emitter 1 and an adjacent light detector 2, both adapted for placement at a surface 3 of the composite material 4. The method further includes emitting light of a predetermined intensity from the light emitter into the surface, and, with the light detector, detecting an intensity of the portion of the emitted light returned by diffusion or backscattering to the surface. The method further includes determining a ratio of the intensity of the detected light relative to the predetermined intensity. The method further includes measuring the volume fraction of reinforcement at the surface of the composite material by comparing the determined intensity ratio to a calibration scale which relates volume fraction of reinforcement at the ...

Implementation concepts and related methods for optical computing devices

Generating broadband light downhole for wellbore application

Gemstone viewer

Biofilm sensor

Cable-suspended non-destructive inspection units for rapid large-area scanning

Imaging device

An imaging device for imaging a microfluidic chip, such as an organ-on-chip, comprising a light source 2 on an optical axis 4, a light absorbing baffle 12, 30 to remove wide-angle light and having first and second openings, wherein the first opening is oriented towards the light source, and a detector 19 arranged so that a face of the detector is oriented towards the second opening of the baffle. Preferably the baffle is an array comprising multiple baffles to provide narrow apertures, which may be tubular and have a square cross section. Preferably a light scattering panel 5 is positioned between the light source and the baffle. Preferably the light source is movable along the optical axis. Also claimed is a system comprising a light source on an axis, a light absorbing baffle with a longitudinal axis, a detector and an actuator configured to move the light source in line with the longitudinal axis of the baffle.

Spectrophotometric instrument

A spectrophotometric instrument for the quantitative measurement of an optical property of an analyte in a sample cell at one or more wavelengths comprising: an instrument housing which houses a source of electromagnetic (EM) radiation and a detector between which in use the EM radiation passes along the optical path; an optical pot for accommodating the sample cell in the optical path, wherein the optical pot is seated inside the instrument housing; and a flexible restraining cradle mounted circumferentially on the optical pot in a sealing arrangement with the instrument housing, wherein the flexible restraining cradle is adapted to restrainedly accommodate the sample cell in the optical path. The flexible restraining cradle may be overmoulded onto the optical pot. It may comprise an annular collar fitted to the mouth of the optical pot. The annular collar may be at least partly reentrant to encapsulate the upper rim of the optical pot. The flexible cradle may comprise a plurality of spaced ...

Magnetic stabilisation method and system in infrared, visible and ultraviolet spectroscopy

In a spectroscopic analysis system, a broadband light source (101, Fig. 1) emits infra-red, visible or ultra-violet light which is transmitted through a fluid in a sample cell (107, Fig. 1) to a broadband detector (112, Fig. 1). Changes in transmitted intensity are related to a measurand in the fluid. A rotatable optical modulator or chopper 601, driven by an electric motor and located in the optical path, has light-transmissive optical elements 603, and non-transmissive regions. A non-contact magnetic field generator 602 applies a magnetic field to the modulator or chopper to damp or brake the rotation. In an aspect, the modulator is an electrically conductive, non-ferromagnetic wheel, disc or cylinder in which eddy currents are induced. Optical elements 603 may be apertures, filters, cuvettes etc. A Hall effect sensor, rotary encoder, optical switch etc may determine angular speed or position of the modulator, and a PID controller may be used to maintain rotation speed at a setpoint by ...

ARRANGEMENT OF A SPECTROSCOPIC ANALYZER OPPOSITE A VIEWING PORT AT A MISCHBEHÄLTER

AUTOMATISCHER ANALYSATOR UND OPTISCHES MESSVERFAHREN ZUR GEWINNUNG VON MESSSIGNALEN VON FLÜSSIGEN MEDIEN

Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur Durchführung von chemischen, biochemischen und/oder immunchemischen Analysen von flüssigen Proben, die in einem Probenlager (920) eines automatischen Analysators (100) vorliegen, unter Zuhilfenahme von flüssigen Reagenzien, die in zumindest einem Reagenzienlager (950a, 950b) des Analysators (100) vorliegen, mit Küvetten (201) zur Aufnahme der flüssigen Proben und Reagenzien, wobei eine Vielzahl von Küvetten als zumindest ein stationäres, lineares Küvettenarray (200) im Analysator angeordnet ist. Der Analysator weist eine optische Messeinheit (500), mit einer stationären Lichtbereitstellungseinheit (540) auf, die zumindest eine Lichtverteilereinrichtung (542) aufweist, die das Licht mehrerer im UV/VIS/NIR-Wellenlängenbereich spektral unterschiedlich emittierender LED-Lichtquellen (541) in die Eintrittsfenster (202) der einzelnen Küvetten (201) des Küvettenarrays (200) einspeist, wobei die optische Messeinheit (500) weiters mit ...

Method for measuring the oxygen content of the head space gas in a beverage can

Die Erfindung betrifft ein Verfahren zur Messung des Sauerstoffgehalts des Kopfraumgases in einer Getränkedose (6), mit insbesondere gekrümmten Boden (20), - wobei die Getränkedose (6) auf dem Kopf stehend, mit dem Boden (20) entgegen der Schwerkraft angeordnet wird, sodass sich das Kopfraumgas im Bereich des Bodens sammelt, - wobei mit einem auf einem Anstechkopf (1) angeordneten hohl ausgebildeten Piercer (2) eine Entnahmeöffnung in den Boden (20), insbesondere in das Zentrum des Bodens (20), der Getränkedose (6) eingebracht wird, in die ein Entnahmerohr (3) eindringt und wobei die Entnahmeöffnung mittels am Piercer (2) oder dem Anstechkopf (1) angeordneten Dichtelementen luftdicht abgedeckt wird, wobei der Flüssigkeitsspiegel in der Getränkedose (6) über das Entnahmerohr (3) derart abgesenkt wird, dass zwischen dem mit Kopfraumgas gefülltem Kopfraum (4) und der Entnahmeöffnung eine direkte Verbindung besteht, wobei nach Absenken des Flüssigkeitsspiegels das im Kopfraum (4) der Getränkedose ...

ANALYZER AND METHOD FOR IMPLEMENTATION OF CHEMICAL, BIOCHEMICAL AND/OR IMMUNOCHEMICAL ANALYSES

Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur Durchführung von chemischen, biochemischen und/oder immunchemischen Analysen von flüssigen Proben, die in einem Probenlager (920) eines automatischen Analysators (100) vorliegen, unter Zuhilfenahme von flüssigen Reagenzien, die in zumindest einem Reagenzienlager (950a, 950b) des Analysators (100) vorliegen, mit Küvetten (201) zur Aufnahme der flüssigen Proben und Reagenzien, wobei eine Vielzahl von Küvetten als zumindest ein stationäres, lineares Küvettenarray (200) im Analysator angeordnet ist. Der Analysator weist verfahrbare und stationäre Automatenkomponenten auf, wobei zumindest zwei Automatenkomponenten unabhängig voneinander entlang oder parallel zu der durch das lineare Küvettenarray (200) definierten Bewegungslinie in x-Richtung verfahrbar ausgeführt sind und jeweils Zugriff auf unterschiedliche Küvetten (201) oder Gruppen von Küvetten (201) in frei wählbarer Reihenfolge aufweisen.

Method for measuring the oxygen content of the head space gas in a beverage can

Die Erfindung betrifft ein Verfahren zur Messung des Sauerstoffgehalts des Kopfraumgases in einer Getränkedose (6), mit insbesondere gekrümmten Boden (20), - wobei die Getränkedose (6) auf dem Kopf stehend, mit dem Boden (20) entgegen der Schwerkraft angeordnet wird, sodass sich das Kopfraumgas im Bereich des Bodens sammelt, - wobei mit einem auf einem Anstechkopf (1) angeordneten hohl ausgebildeten Piercer (2) eine Entnahmeöffnung in den Boden (20), insbesondere in das Zentrum des Bodens (20), der Getränkedose (6) eingebracht wird, in die ein Entnahmerohr (3) eindringt und wobei die Entnahmeöffnung mittels am Piercer (2) oder dem Anstechkopf (1) angeordneten Dichtelementen luftdicht abgedeckt wird, wobei der Flüssigkeitsspiegel in der Getränkedose (6) über das Entnahmerohr (3) derart abgesenkt wird, dass zwischen dem mit Kopfraumgas gefülltem Kopfraum (4) und der Entnahmeöffnung eine direkte Verbindung besteht, wobei nach Absenken des Flüssigkeitsspiegels das im Kopfraum (4) der Getränkedose ...

METHOD AND APPARATUS FOR ADJUSTING AN OPTICAL DETECTOR RADIATION POWER IN PASSING

Die Erfindung betrifft ein Verfahren zur Einstellung der Strahlungsleistung des Lichts, das in einen optischen Detektor (3a,3b) gelangt, durch welche Objekte in einem einschichtigen Materialstrom von Objekten identifiziert werden, wobei - die Objekte mit zumindest einer Lichtquelle (2a,2b) bestrahlt werden, - zumindest ein Teil des emittierten Lichtes mit den Objekten in Wechselwirkung tritt, - das Licht der Wechselwirkung von zumindest einem Detektor (3a,3b) erfasst wird, - aufgrund des Vergleiches des detektierten Lichts mit bekannten Daten betreffend den Zusammenhang zwischen unterschiedlichen Objekten und deren Licht der Wechselwirkung, verschiedene Objekte identifiziert werden. Um die Lebensdauer der zumindest einen Lichtquelle (2a,2b) zu erhöhen, wird die in den zumindest einen Detektor (3a,3b) eintretende Strahlungsleistung über eine verstellbare Blende (4) in Abhängigkeit von der Strahlungsleistung des von der Lichtquelle (2a,2b) emittierten Lichts eingestellt.

System and method for analyzing drill core samples

A System for collecting and processing data concerning physical features of drill core samples with three-dimensional shape and appearance. The system comprises a contact less analytical apparatus for measuring and collecting data of at least some part of the outer surface of the drill core samples, a first data-storing means for storing data collected by the analytical apparatus,a processing unit that applies one or more data evaluation algorithms on the data stored in the first data storage means in order to extract data regarding physical features of the drill cores (1) as an output,and a second data storage means for storage of the resulting output from the processing unit. The system is also related to a method for measuring and collecting data on the three-dimensional shape and appearance of drill core samples, such as planar discontinuities including orientation marks on the drill core samples.

Portable moisture analyzer for natural gas

Methods, devices, and systems are provided for analyzing the moisture content in natural gas. In one embodiment, a portable moisture analyzer system is provided and can include a moisture analyzer and a housing. The moisture analyzer can include a tunable diode laser absorption spectrometer (TDLAS) and a natural gas sample conditioning system. The TDLAS can be configured to detect water vapor content within a natural gas sample. The sample conditioning system can be in fluid communication with the TDLAS and can be configured to condition at least one of temperature, flow rate, and pressure of a natural gas sample. The housing can be configured to receive the moisture analyzer therein and to protect the moisture analyzer from vibration and/or shock.

Light condensing device for inspecting quality inside fruits and vegetables, system comprising same, and use method thereof

A light condensing device for inspecting the quality inside fruits and vegetables, resolving the issue in which manually holding fruits for inspection is inefficient and cannot be used in large-scale fruit packaging production. The device comprises a housing (1), a halogen lamp (2), a diaphragm (3), a plano-convex lens support (4), a first plano-convex lens (5), a reflector lens fixing plate (6), a reflector (7), a plano-convex lens fixing plate (8), and a second plano-convex lens (9). The housing (1) is a sealed and non-transparent housing. The halogen lamp (2) is fixedly disposed at a left end of the housing (1), and extends into an inner portion of the housing (1). A pluggable diaphragm (3) is disposed at the right side of the halogen lamp (2), and is used to guide a lighting direction of the halogen lamp (2). The diaphragm (3) passes through the inner portion of the housing (1). The plano-convex lens support (4) is fixedly disposed inside the housing (1) at the right side of the diaphragm ...

Optical density instrument and systems and methods using the same

Instruments, systems, and methods for measuring optical density of microbiological samples are provided. In particular, optical density instruments providing improved safety, efficiency, comfort, and convenience are provided. Such optical density instruments include a handheld portion and a base station. The optical density instruments may be used in systems and methods for measuring optical density of biological samples.

Devices, systems, and methods for agrochemical detection and agrochemical compositions

Systems, devices, and methods for detecting agrochemicals in environments associated with agricultural equipment are described. Certain agrochemicals that are formulated for being detected using the systems, devices, and methods disclosed herein are also described. The devices, systems, and methods disclosed herein are generally configured to use spectral characteristics to detect agrochemicals in an environment associated with agricultural equipment. The spectral characteristics can be analyzed in various ways to provide different types of information about the agrochemicals and/or the environment.

Improved imaging apparatus with selectable moveable stage

Determining the position and angular orientation of food products

A portioning system (10) includes a scanner (16) for scanning a passing poultry breast (14). A cutting device (18), a slicing device (20) and/or other equipment may be used to portion, trim, or otherwise process the poultry breast under the control of a 5 computer (22). The computer also utilizes the information from the scanner to determine position and the angular orientation of the poultry breast relative to a reference line by determining directional lines corresponding to physical attributes of the poultry breast. One directional line is related to the principal axis of the poultry breast, determined from the axis of least inertia of the poultry breast. Other directional lines may correspond to 10 the locations of notches, projections, linear depressions, or other physical anatomical features of the poultry breast. 32 12 18 20 34 NETWORK CONVEYOR CUTTING SLICER SENSORS 10 COMPUTER -- 22 --------- F-- -- - I CPU I I MEMORY I 24 - +26 USER OUTPUT INTERFACE 28 DE VICE 36,38 4a 14b 14c ...

Bio-luminescence monitoring apparatus and method

System and method for detecting biofilm growth in water systems

A system and method for monitoring or detecting a level of biofilm growth in a fluid system and controlling operating parameters of the fluid system based a measured level of growth. The monitoring system and method comprises a dye injection system for periodically injecting dye into a portion of fluid from the fluid system, passing the portion of fluid though a narrow lumen tube to achieve laminar flow and using a light source and optical sensor to detect a transmission or emission indicating a level of biofilm growth in the tube corresponding to a level of growth on components in the fluid system. Information based upon the measurements or calculations made by the monitoring system may be used to manually or automatically alter various operating parameters to control the fluid system and aid in maintaining stable operation of the fluid system within preferred specifications.

System and method for detecting biofilm growth in water systems

A system and method for monitoring or detecting a level of biofilm growth in a fluid system and controlling operating parameters of the fluid system based a measured level of growth. The monitoring system and method comprises a dye injection system for periodically injecting dye into a portion of fluid from the fluid system, passing the portion of fluid though a narrow lumen tube to achieve laminar flow and using a light source and optical sensor to detect a transmission or emission indicating a level of biofilm growth in the tube corresponding to a level of growth on components in the fluid system. Information based upon the measurements or calculations made by the monitoring system may be used to manually or automatically alter various operating parameters to control the fluid system and aid in maintaining stable operation of the fluid system within preferred specifications.

Systems and methods for detection of cells using engineered transduction particles

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Methods of analyzing a reservoir fluid sample during or after collection of the sample using an analyzer

A method of analyzing a fluid sample from a reservoir comprises: collecting the sample in a sample container, wherein the sample container includes a sample receptacle, and wherein the step of collecting comprises allowing or causing the sample to flow into the sample receptacle; determining at least one property of the sample using an analyzer, wherein the analyzer is located at one end of the sample receptacle, wherein the step of determining comprises: (A) contacting the sample with radiated energy; and (B) detecting the interaction between the radiated energy and the sample, wherein the step of determining is performed during the step of collecting and during fluid flow of the sample into the sample receptacle. Another method comprises: transferring the sample from the sample container to a second container, wherein the step of determining is performed after the step of collecting and during fluid flow of the sample.

Optical sources having a strongly scattering gain medium providing laser-like action

AUXILIARY DETECTION DEVICE FOR AFLATOXIN

Abstract An auxiliary detection device for aflatoxin and mycotoxins comprises an ultraviolet lamp for detection in a case with a sliding mechanism comprising reflecting plates, a derivation tube device and grooves for slidingly matching with a limiting piece. Drawings of Description Fig.1I Fig. 2 ...

Spectroscopic sample holder

Stabilized capillary microjet and devices and methods for producing same

DEVICE AND METHOD FOR IRRADIATION OF SMALL PARTICLES FOR ANALYSIS OF THE QUALITY OF THE PARTICLES

A device for irradiation of small particles, such as grains from cereals and like crops, for analysis of the quality of the particles, comprises a sample- feeding carrier (30), which has sample holders and is adapted to take up particle samples (2), which each comprise at least one particle, in the sample holders and transport the particle samples (2) to a place for irradiation (34). The device further comprises a radiating device (36) emitting electromagnetic radiation for irradiation of the particle samples (2), and radiation guides (22). The radiation guides (22) are attached on the sample- feeding carrier (30) for guiding the radiation emitted by the radiating device (36) to a particle sample (2) in a sample holder, when the particle sample (2) has been fed to the place for irradiation (34).

DEVICE AND SYSTEM FOR COLLECTING AND ANALYZING VAPOR CONDENSATE, PARTICULARLY EXHALED BREATH CONDENSATE, AS WELL AS METHOD OF USING THE SAME

The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile- phone, and performing such collection and analysis by a person without any professionals.

INFRA-RED SPECTROSCOPY SYSTEM

A sample slide (100) for use in a spectrometer (501), wherein the sample slide comprises a plurality of sample-receiving portions (111 -114) provided on a sample side (115) of the slide, and a plurality of beam-receiving portions (121 -124) provided on a beam-receiving side (125) of the slide, each beam-receiving portion being arranged opposite a respective sample-receiving portion, and wherein each beam-receiving portion is configured to act as an internal reflection element (IRE). A device (300) for use with a spectrometer (501) comprises a stage (330) configured to receive a sample slide (100); and a moving mechanism (360) configured to move the sample slide relative to a sample-measuring location (320) of the device. Associated methods for preparing a sample and measuring a sample are also disclosed.

FLOW ASSAY ANALYZER

Described is a lateral flow high throughput assay device analyzer for preparing and analyzing a plurality of lateral flow assay samples. The analyzer comprises a cartridge stage for supporting an assay cartridge, an elevation adjustment mechanism, and a translation adjustment mechanism for aligning the cartridge stage and assay cartridge relative to a vertical support structure, fluid metering device, and detection device for high throughput lateral flow assay analysis.

SEMICONDUCTOR LASER DEVICE

External resonator-type lasers as configurations for narrowing the spectral line widths of semiconductor lasers to approximately 10 kHz suffer from the problem that a large number of components are required and need to be assembled with high accuracy, and thus, control circuits become complicated. Wavelength variable lasers based on DFB lasers have also been known, but even wavelength variable lasers based on DFB lasers have limits in narrowing of spectrum line widths because it is difficult to uniformly form long resonators due to production variation. The semiconductor laser device according to the present invention has a semiconductor laser that oscillates in a single mode and has a low-loss optical wave circuit using quartz glass arranged on a common substrate. The optical wave circuit is configured such that a part of light outputted from the semiconductor laser propagates a certain length of an optical path, is reflected by a reflector, and returns to the semiconductor laser. Alternatively ...

A SAMPLE HOLDER FOR IMAGING A PLURALITY OF SAMPLES

A sample holder comprises one or more elongated sample tubes. The one or more elongated sample tubes are adapted for accommodating a plurality of samples to be imaged at an imaging position. The imaging position is defined by at least one illumination objective lens and at least one detection objective lens of a microscope. A microscope is disclosed, comprising at least one illumination objective lens and at least one detection objective lens, which define an imaging position. The microscope further comprises a sample holder for holding a plurality of samples. The sample holder is moveable with respect to the imaging position.A method for imaging a plurality of samples by means of the microscope is disclosed.

METHOD FOR READING AN IMAGE SENSOR

Imaging device (2) and method for reading an image sensor (1) in the imaging device (2). The imaging device (2) has optics (3) with which the imaging device (2) can be focused on objects (4). The image sensor (1) has a plurality of sensor lines (5), wherein each sensor line (5) comprises a plurality of preferably linearly arranged, preferably individually readable pixel elements (6). A pixel range (7) is defined with the pixel range (7) comprising at least a section of a sensor line (5). The reading of the image sensor (1) is restricted to the pixel elements (6) in the pixel range (7).

DEVICES AND METHODS FOR PROGRAMMABLE MICROSCALE MANIPULATION OF FLUIDS

The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components. Other aspects of this invention include an apparatus and method to perform volumetric quantitation of fluids, an apparatus to program arbitrary connections between a set of input capillaries and a set of output capillaries, and a method to transport fluid in centripetal device from a larger to a smaller radius. In addition, the present invention also is directed to a method to determine the radial and polar ...

A SENSOR DEVICE AND A METHOD OF DETECTING A COMPONENT IN GAS

The invention relates to a sensor device (1) comprising a planar substrate (3) defining a substrate plane (4) and a waveguide (2) for guiding an electromagnetic wave. The waveguide (2) extends in a length direction in a waveguide plane (4´) parallel to the substrate plane (4) and has a width (W, w) and a height (h) wherein the width (W, w) to height (h) ratio is more than 5. The height (h) of the waveguide (2) is less than the wavelength of the electromagnetic wave. The waveguide (2) is supported on the substrate (3) by a support structure (5) extending from the substrate (3) to the waveguide (2), along the length direction of the waveguide (2), having a width (Ws) which is smaller than the width (W, w) of the waveguide (2). The invention further relates to a method of detecting a component in gas and a method of fabricating a sensor device (1).

SMARTPHONE ENABLED URINALYSIS DEVICE, SOFTWARE, AND TEST PLATFORM

A urinalysis device including a device body having a port for electronic communication with a handheld computing device and holding a test strip for insertion into urine and collecting a sample. A method of using the urinalysis device with a handheld computing device, by taking a urine sample, electronically coupling the urinalysis device to the handheld computing device through the port, obtaining raw data a test strip within the urinalysis device, sending the raw data to the handheld computing device, and further analyzing the raw data. An Application and method of use with a urinalysis device, including a power providing mechanism for recognizing and providing power to the urinalysis device, a data accepting mechanism for accepting raw data from the urinalysis device, a data correcting mechanism for converting and correcting raw data from the urinalysis device to results, and a reporting mechanism for populating a reporting form with results.

SPECTROSCOPY DATA DISPLAY SYSTEMS AND METHODS

Spectroscopy data are correlated to physical locations on a sample. A laser beam is scanned along a beam trajectory relative to the sample located in a sample chamber. The laser beam disassociates material from the sample along the beam trajectory to produce an aerosol of the disassociated material within the sample chamber. A fluid is passed through the sample chamber to transport the disassociated material to a spectrometer for determining spectroscopy data values of a selected element along the beam trajectory. The spectroscopy data values are correlated with respective locations of the sample along the beam trajectory, and an image is displayed of at least a portion of the sample including the respective locations along the beam trajectory where the material was disassociated by the laser beam. The image includes indicia of the spectroscopy data values at their correlated locations.

OPTICAL SOURCES HAVING A STRONGLY SCATTERING GAIN MEDIUM PROVIDING LASER-LIKE ACTION

A gain medium is comprised of a multi-phase system wherein: a first phase is an electromagnetic radiation emission phase; a second phase is an electromagnetic radiation scattering phase; and a third phase is a transpare nt matrix phase. By example, the emission phase may consist of dye molecules, t he scattering phase may consist of high contrast particles, and the matrix phas e may consist of a solvent such as methanol. In some embodiments of this invention the emission and scattering phases may be the same phase, as when semiconductor particles are employed. A smallest dimension of a body compris ed of the gain medium may be less than a scattering length associated with the scattering phase. It is shown that nearly thresholdless laser behavior is observed in strongly scattering optically pumped dye-methanol solutions containing colloidal TiO2 or Al2O3 ruby nanoparticles. The emission from the high gain colloid exhibits a slope change in the linear input-output characteristics above a ...

DEVICE AND METHOD FOR CREATING AEROSOLS FOR DRUG DELIVERY

A drug delivery device and method is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device is comprised of a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel i s surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled form an opening. The opening from which the gas is expelled is positioned directly i n front of the flow path of liquid expelled from the feeding channel. Various parameters ar e adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exi ts the pressure chamber opening and is aerosolized. The aerosolized particles having a unifo rm diameter in the range of about 1 to 5 microns are inhaled into a patient's lungs and thereafter reach the patient's circulatory system ...

System und Verfahren zum Nachweis des Verteilungsverhältnisses von Chlorophyll und Lutein in Gurkenblättern.

Die vorliegende Erfindung betrifft ein System zur Erfassung eines zweidimensionalen spektralen Transmissionsbildes der Blattoberfläche eines Gurkenblattes bei einer Kennwellenlänge, um die Verteilung des Chlorophyll-Gehalts oder des Lutein-Gehalts des Gurkenblattes nachzuweisen. Das System umfasst ein Lichtquellenmodul zum Bestrahlen von mindestens einem Teil eines Gurkenblattes, ein Bildgebungsmodul zur Erfassung eines zweidimensionalen spektralen Transmissionsbildes und mindestens ein Steuermodul zum Steuern des Lichtquellenmoduls und des Bildgebungsmoduls und zum Berechnen des Chlorophyll-Gehaltsverteilungsdiagramms und des Lutein-Gehaltsverteilungsdiagramms des Gurkenblattes. Das Lichtquellenmodul umfasst einen Hohlkörper mit einem Hohlraum (1) und mindestens eine Mikro-LED-Lineararray-Lichtquelleneinheit (4). Die Innenwand des Hohlkörpers ist mit einer diffus reflektierenden Beschichtung (2) versehen, und die Oberfläche der mindestens einen Mikro-LED-Lineararray-Lichtquelleneinheit ...

Detecting equipment for Raman spectrum and monitoring method for detection safety of detecting equipment

Portable ultraviolet detection spectrometer

Liquid refractive index measurement device and method based on DVD grating structure

Occult blood testing apparatus and occult blood testing method

Quick detection reagent for hydrogen peroxide in food, kit and detection method

Device and method for detecting content of chlorophyll a in water

High-efficiency formaldehyde detection device based on phenol reagent spectrophotometric method

Quick check tool in patrol check of faults of lightning arrester of 10kV overhead line

High-end glass processing equipment used for light transmission or imaging

Light intensity enhancement system and method for enhancing light intensity

Fluorescence immunoassay instrument and detection method thereof

Hybrid planar optofluidic integration

optical system for sample detection and sample analysis device

The invention discloses an optical system for sample detection. The optical system comprises a light source, a converging projection component, a sample containing component, a light beam collecting component, a light splitting component and a photoelectric detecting component, wherein the converging projection component is used for converging light rays emitted by the light source; the sample containing component is used for containing a detected sample; the light beam collecting component is used for receiving light rays which are transmitted from the sample containing component and carry characteristic information of the sample; the light splitting component is used for decomposing polychromatic light which is collected by the light collecting component into independent light spectrums or light spectrum bands; the photoelectric detecting component is used for receiving light signals with different wavelengths, which are separated by the light splitting component; the converging projection ...

Lens sealing precision adjusting device based on stable cavity absorption spectrum technique

Systems and methods for improved focus tracking using a light source configuration

Near-infrared laser band transmittance measurement system based on light source modulation technology

Testing device

Rotary-type tobacco rod hole-size detecting device

Annular-imaging hole detecting device for tipping paper perforated cigarettes

Surface defect detection system and method

Using the method of forming the surface of the micro-plasma

Устройство для обнаружения молекулярных примесей в атмосфере по колебательно-вращательным спектрам

Полезная модель относится к устройствам для измерения концентрации вредных молекулярных примесей в газообразной фазе, преимущественно в окружающей нас атмосфере, спектроскопическими методами. Устройство включает в себя источник сплошного спектра и гребенчатый оптический фильтр на основе интерферометра Фабри-Перо, пропускающий полный набор линий колебательно-вращательного спектра молекулы, а также систему регистрации и устройство одновременной модуляции всего набора частот пропускания интерферометра за счет периодического изменения оптической толщины промежутка между его зеркалами. На выходе интерферометра устанавливается объектив и диафрагма, осуществляющие суммирования интенсивности всех пропущенных линий, что обеспечивает увеличение измеряемого сигнала по крайней мере на порядок величины и соответствующее увеличения чувствительности устройства для обнаружения молекулярных примесей. Технический результат заключается в возможности многократного повышения чувствительности измерительной системы и ее механической стабильности. 2 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 171 813 U1 (51) МПК G01N 21/01 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21)(22) Заявка: 2016114756, 15.04.2016 (24) Дата начала отсчета срока действия патента: 15.04.2016 (72) Автор(ы): Иванов Михаил Павлович (RU), Толмачев Юрий Александрович (RU) 16.06.2017 Приоритет(ы): (22) Дата подачи заявки: 15.04.2016 Адрес для переписки: 199034, Санкт-Петербург, Университетская наб., 7/9, СПбГУ, Главное Управление по использованию и защите интеллектуальной собственности, начальнику ОПОЛРИД Матвееву А.А. (56) Список документов, цитированных в отчете о поиске: RU 2451285 C1, 20.05.2012. US 4941747 A, 17.07.1990. US 6064488 A, 16.05.2000. RU 2010141803 A, 10.05.2012. U 1 1 7 1 8 1 3 R U (57) Формула полезной модели Устройство для обнаружения молекулярных примесей в атмосфере по колебательновращательным спектрам газов, содержащее ...

Apparatus, optical assembly, method for inspection or measurement of an object and method for manufacturing a structure

An optical assembly for a system for inspecting or measuring of an object is provided that is configured to move as a unit with a system, as the system is pointed at a target, and eliminates the need for a large scanning (pointing) mirror that is moveable relative to other parts of the system. The optical assembly comprises catadioptric optics configured to fold the optical path of the pointing beam and measurement beam that are being directed through the outlet of the system, to compress the size of the optical assembly.

Optical cable measurement equipment with function of operating guidance

An optical cable measurement equipment with function of operating guidance includes a circuit board, a central processing unit (CPU), a measurement module, an output interface, an input interface and a power supply module. The CPU is arranged on and electrically connected with the circuit board. The measurement module is configured for implementing functions of optical cable measurement. The output interface is configured for outputting a prompting signal to guide a user to operate the optical cable measurement equipment. The input interface is configured for receiving operations of the user and generating a feedback signal. The CPU generates operating instruction according to the feedback signal. The power supply module is configured for providing required power of the optical cable measurement equipment. The above-mentioned optical cable measurement equipment is able to provide operating guidance by prompting signal of sound/voice, light, text or pattern to guide users to complete operating flow.

Microarray-based sample analysis system

A microarray-based sample analysis (MBSA) system includes a cartridge holder adapted to receive a replaceable cartridge that is configured to receive a detachable, replaceable sample analysis unit containing one or more reaction chambers for sample analysis; a fluid control subsystem that controls fluid flow; and an optical subsystem configured to capture an image of the microarray.

SUCTION APPARATUS, SEMICONDUCTOR DEVICE OBSERVATION DEVICE, AND SEMICONDUCTOR DEVICE OBSERVATION METHOD

A suction unit includes a main body portion having a first surface on which a semiconductor wafer W is arranged and a second surface opposite to the first surface , and in which a through-hole that penetrates through the first surface and the second surface is formed and a light transmitting portion having a light incident surface and a light emitting surface , and which is fitted to the through-hole . Further, in the first surface , a first suction groove for vacuum sucking the semiconductor wafer W to fix the semiconductor device D to the light incident surface is formed, and in the second surface , a second suction groove for vacuum sucking the solid immersion lens S to fix the solid immersion lens S to the light emitting surface is formed. 1. A suction unit to be used for a semiconductor device observation apparatus for performing observation of a semiconductor device by use of a solid immersion lens , comprising:a main body portion having a first surface on which a semiconductor wafer formed with the semiconductor device is arranged and a second surface that is a surface opposite to the first surface, and in which a through-hole that penetrates through the first surface and the second surface is formed; anda light transmitting portion having a light incident surface onto which light from the semiconductor device is made incident and a light emitting surface from which light made incident from the light incident surface is emitted, and which is fitted to the through-hole so that the light incident surface is exposed to a side of the first surface and the light emitting surface is exposed to a side of the second surface, whereinin the first surface, a first suction groove for vacuum sucking the semiconductor wafer to fix the semiconductor device to the light incident surface is formed, andin the second surface, a second suction groove for vacuum sucking the solid immersion lens to fix the solid immersion lens to the light emitting surface is formed.2. The suction ...

METHOD AND APPARATUS FOR DETERMINING THERMAL MAGNETIC PROPERTIES OF MAGNETIC MEDIA

An apparatus and method of testing a magnetic medium at temperatures of interest is disclosed. Properties of the magnetic medium are determined by focusing light from a source of polarized light on a magnetic surface of the magnetic medium; measuring polarization of resulting reflected light due to the magneto-optical Kerr effect, using, for example a measuring subsystem; and varying the light source to heat the magnetic material where incident to pre-defined temperatures, thereby allowing determination of the magnetic properties using the magneto-optical Kerr effect at said pre-defined temperatures. 1. An apparatus for testing a magnetic medium at multiple temperatures of interest , comprising:a single light source to provide polarized light incident on a magnetic surface of said magnetic medium, said polarized light being capable of being reflected for measurement of the magneto-optical Kerr effect and of adjustment for heating said surface at a point of incidence to said multiple temperatures of interest;a measuring subsystem to measure polarization of reflected light due to the magneto-optical Kerr effect, said reflected light reflected from said magnetic medium in response to said polarized light incident on said magnetic surface,wherein said polarized light heats said magnetic surface where said polarized light is incident, to said multiple temperatures of interest, to allow determination of magnetic properties of said magnetic medium at said multiple temperatures of interest using the magneto-optical Kerr effect.2. The apparatus of claim 1 , wherein intensity of said polarized light is varied.3. The apparatus of claim 1 , wherein frequency of said polarized light is varied.4. The apparatus of claim 1 , w herein duration of applied polarized light is varied.5. The apparatus of claim 1 , further comprising a temperature sensor to sense a temperature of said predetermined spot claim 1 , wherein the temperature sensor is configured to receive reflected light ...

METHOD FOR MEASURING PARTICLES ADHERING TO A BODY

The aim of the present disclosure is to reliably measure particles () adhering to a body (). To this end, particles are transferred from the body () to a test body () and measured thereon. In this way, for example, the performance of dust collectors for, for example, pharmaceutical tablets can be reliably determined with a high level of repeat accuracy. 1. Method for measuring particles adhering to a body , wherein particles are transferred from the body to a test body and are measured on the latter.2. Method according to claim 1 , wherein the test body has a color that differs from the color of the body.3. Method according to claim 1 , wherein the test body consists of a plastically or elastically deformable material.4. Method according to claim 3 , wherein the test body consists of synthetic material claim 3 , rubber claim 3 , or natural rubber.5. Method according to claim 3 , wherein the test body has the shape of a membrane.6. Method according to claim 1 , wherein the transfer of the particles to the test body is achieved by an electrostatic potential difference.7. Method according to claim 1 , wherein the transfer of the particles to the test body is achieved by a contact between the body and the test body.8. Method according to claim 1 , wherein the surface of the test body is coated with a pressure sensitive adhesive.9. Method according to claim 1 , wherein the measurement of the particles is achieved by analyzing a sector of the test body with the particles transferred thereto.10. Method according to claim 9 , wherein a digital image of the sector is recorded and electronically analyzed.11. Method according to claim 9 , wherein the analysis comprises determining the ratio of the sum of the projected areas of the particles relative to the total surface area of the sector.12. Method according to claim 9 , wherein the analysis includes determining the particle size distribution.13. Method according to claim 8 , wherein the analysis includes determining the ...

STRUCTURE FOR PARTICLE IMMOBILIZATION AND APPARATUS FOR PARTICLE ANALYSIS

A structure for particle immobilization has a plurality of holding holes for holding respective test particles in order to detect light emitted from a substance which indicates the presence of a component for constructing each of the test particles, and the structure for particle immobilization comprises a flat plate substrate , and a holding unit which is arranged on the substrate and which is formed with the plurality of holding holes . In this configuration, a light shielding film which reduces light noise is provided for the substrate or the holding unit in order that the light noise such as the background noise and the crosstalk noise can be reduced, and a large number of test particles can be optically observed highly sensitively and highly accurately. 1. A structure , comprising:a flat plate substrate;a holding unit arranged on said substrate, wherein the holding unit is formed with a plurality of holding holes, which hold respective test particles to detect light emitted from a substance and thereby indicate the presence of a component for constructing each of said test particles; anda light shielding film provided for said substrate or said holding unit, wherein the light shielding film reduces light noise generated from said holding unit.2. The structure of claim 1 , wherein said light shielding film is provided on an upper surface of said holding unit or at an intermediate layer of said holding unit.3. The structure of claim 2 , wherein:said holding unit comprises said light shielding film on the upper surface of said holding unit;the structure further comprises an insulator film between said light shielding film and said substrate; andsaid holding holes are opened on said light shielding film positioned on the upper surface of said holding unit and extend to said substrate via said insulator film.4. The structure of claim 3 , wherein said light shielding film is provided on the entire portion other than said plurality of holding holes of the upper ...

BIOLOGIC FLUID SAMPLE ANALYSIS CARTRIDGE

A biological fluid sample analysis cartridge, analysis system, and method for analyzing a biologic fluid sample are provided. The cartridge includes a collection port, at least one channel within the cartridge in fluid communication with the collection port, a passage in fluid communication with the at least one channel, and an analysis chamber mounted on a tray. The tray is mounted relative to the cartridge and selectively positionable relative to the passage in a first position where the analysis chamber will engage a bolus of sample extending out from the passage to permit selective transfer of sample from the bolus to the analysis chamber. 1. A biological fluid sample analysis cartridge , comprising:a collection port;at least one channel within the cartridge in fluid communication with the collection port;a passage in fluid communication with the at least one channel; andan analysis chamber mounted on a tray, which tray is mounted relative to the cartridge and selectively positionable relative to the passage in a first position where the analysis chamber will engage a bolus of sample extending out from the passage to permit selective transfer of sample from the bolus to the analysis chamber.2. The cartridge of claim 1 , wherein the passage includes a first end and a second end claim 1 , and which first end is in fluid communication with the at least one channel claim 1 , and which second end is configured to permit the formation of a bolus of sample extending out from the second end.3. The cartridge of claim 2 , wherein the analysis chamber includes a base chamber panel and an upper chamber panel claim 2 , separated from one another by a chamber height claim 2 , and each of the panels includes a sample entry edge.4. The cartridge of claim 3 , wherein the sample entry edges of the panels are substantially aligned with one another.5. The cartridge of claim 3 , wherein in the first position the tray is mounted relative to the cartridge so that at least one of the ...

CARTRIDGE WITH LARGE-SCALE MANUFACTURING DESIGN

The invention relates to a cartridge () and an examination apparatus () for optical examinations of a sample. The cartridge () comprises a transparent bottom layer () that is of substantially uniform thickness and a top layer () comprising a sample chamber (SC). The bottom layer and the top layer are preferably laminated onto each other, for example in a C roll-to-roll process. The bottom layer () is provided with structures like gratings () that allow the incoupling or outcoupling of light. 1. A cartridge for optical examinations of a sample , comprising:a) a transparent bottom layer that is of a thickness with a variation of less than about 10%;b) at least one top layer that is disposed above the bottom layer and that comprises a sample chamber (SC) in which the sample can be provided;{'b': '1', 'wherein the bottom layer comprises a light-input structure for coupling an input light beam (L) into the cartridge and for directing it to the sample chamber (SC)'}said light-input structure being designed such that at least a part of the light passing through this structure is totally internally reflected at the interface to the sample chamber (SC).2. The cartridge according to claim 1 ,characterized in that the bottom layer and/or the top layer is made from a flexible sheet, particularly a foil.3. (canceled)4. The cartridge according to claim 1 ,characterized in that the bottom layer comprises a light-output structure for coupling out an output light beam coming from the sample chamber.5. The cartridge according to claim 1 ,characterized in that the light-input structure comprises a grating, a prismatic structure, or a smoothened side window.6. The cartridge according to claim 3 ,characterized in that the light-output structure is designed such that at least a part of the light passing through this structure was totally internally reflected at the interface to the sample chamber.7. The cartridge according to claim 6 ,characterized in that said part of the light is ...

MODIFICATION OF A FLOW CELL TO MEASURE ADSORPTION KINETICS UNDER STAGNATION POINT FLOW AND DEVELOPMENT OF A SETUP CORRECTION PROCEDURE FOR OBTAINING ADSORPTION KINETICS AT THE STAGNATION POINT

This application describes a flow cell to perform experiments under well-controlled hydrodynamic conditions. The resulting cell enables combining the advantages of in-situ spectroscopic ellipsometry with stagnation point flow conditions. An additional advantage is that the proposed cell features a fixed position of the “inlet tube” with respect to the substrate, thus facilitating the alignment of multiple substrates. Theoretical calculations were performed by computational fluid dynamics and compared with experimental data (adsorption kinetics) obtained for the adsorption of polyethylene glycol to silica under a variety of experimental conditions. Additionally, a simple methodology to correct experimental data for errors associated with the size of the measured spot and for variations of mass transfer in the vicinity of the stagnation point is herein introduced. The proposed correction method would allow researchers to reasonably estimate the adsorption kinetics at the stagnation point and quantitatively compare their results, even when using different experimental setups. The applicability of the proposed correction function was verified by evaluating the kinetics of protein adsorption under different experimental conditions. 1. A modification to a flow cell comprising:an inlet conduit comprising an exit port and an inlet port, wherein the inlet port is configured to receive a fluid containing an adsorbate during use;a substrate holder configured to couple to a substrate during use;a light inlet and a light outlet, optically couplable to a substrate coupled to the substrate holder;wherein the inlet conduit is positioned such that fluid flows from the exit port toward the substrate during use and impinges the surface of a substrate, positioned in the substrate holder, at a point substantially coincident with light striking the substrate from the light beam inlet.2. The flow cell of claim 1 , wherein the fluid exits the inlet substantially perpendicular to the ...

Fabrication and use of elevated optical nanoantennas

A nanostructure including a pair of pointed metallic tips in proximity to each other. The pair of pointed metallic tips protrudes from a planar top surface of a substrate by a pair of pillar structures. The pair of pointed metallic tips can enhance optical scattering of materials placed therebetween through plasmonic electromagnetic field effects induced by the proximity of the pair of pointed metallic tips. Perturbation or interference from the substrate can be minimized through the increased distance from the substrate. The pair of pointed metallic tips can be formed by patterning a pair of adhesion material portions on a substrate, by vertically and laterally recessing regions that are not covered by the adhesion material portions, and by depositing a metal on the pair of adhesion material portions.

IN SITU HOLDER ASSEMBLY

An in situ optical specimen holder is disclosed which allows imaging and analysis during dynamic experimentation. This holder assembly includes a set of focusing and reflection optics along with an environmental cell. Electromagnetic radiation can be used to optically excite the specimen in the presence or absence of fluid and the source of such radiation may be located within the body of the holder itself. The spot size of the irradiation at the specimen surface can be varied, thus exciting only a specific region on the specimen. The window type cell provides a variable fluid path length ranging from the specimen thickness to 500 μm. The holder has the provision to continuously circulate fluids over the specimen. The pressure within the cell can be regulated by controlling the flow rate of the fluids and the speed of the pumps. 1. A specimen holder which receives and positions a specimen in an imaging device , said holder comprising:a receptacle for receiving and supporting said specimen;an elongated barrel mounted between said receiver and said receptacle for positioning said specimen at a preselected location within said imaging device and for containing said beam of electromagnetic radiation;a self-contained electromagnetic radiation source andan adjustable lens;said self-contained electromagnetic radiation source and said adjustable lens mounted within said elongated barrel for receiving and focusing said beam of electromagnetic radiations on said specimen at a focus point, said beam of electromagnetic radiations causing an increase in the energy level of a portion of said specimen proximate to the focus point of said beam of optical energy.2. A specimen holder as described in claim 1 , wherein said beam of electromagnetic radiation is selected from the group consisting of an electron beam claim 1 , infrared radiation claim 1 , visible light claim 1 , ultraviolet radiation and X rays.3. A specimen holder as described in claim 1 , wherein said beam of ...

Spectrometer Flip Top Sample Head

A spectrometer sample head including a housing, at least one source of radiation in the housing, and a flip top sample cell including first and second hinged plates and a window through the first plate with a pane in the window, the pane for receiving a sample thereon. The housing includes a channel for receiving the plates when coupled together for placing the sample in the optical path of the radiation. 1. A spectrometer sample head comprising:a housing;at least one source of radiation in the housing; anda flip top sample cell including first and second hinged plates;a window through the first plate with a pane in said window, said pane for receiving a sample thereon;the housing including a channel for receiving the plates when coupled together for placing a sample in the optical path of the radiation.2. The sample head of further including a seal about said window.3. The sample head of in which one said plate includes a plurality of kinematic mounts providing a predefined spacing between the plates.4. The sample head of in which the predetermined spacing is 100 microns.5. The sample head of in which said kinematic mounts are adjustable.6. The sample head of in which there are three kinematic mounts.7. The sample head of in which at least one plate includes a magnet set therein for releasably coupling the plates.8. The sample head of in which there are four spaced magnets in the first plate and four spaced magnets in the second plate.9. The sample head of in which the channel includes at least one edge groove and at least one plate includes a depending shoe which slides in the edge groove.10. The sample head of in which the channel includes opposing edge grooves and one said plate includes spaced hinged members each including a shoe.11. The sample head of in which there are two sources in the housing.12. The sample head of further including a coupler for joining the sample head to a spectrometer.13. The sample head of in which said window is mounted flush within ...

ANNULAR OPTICAL DEVICE

An annular optical device () includes an annular meso-optic () including an annulus () centered about an axis of revolution (A) and a secondary optical structure () substantially coaxial within the annulus (). The secondary optical structure () and the annular meso-optic () are separated by a media () including a media refractive index that is lower than the refractive index of the secondary optical structure. The secondary optical structure () holds a specimen to be radiated by impinging electromagnetic radiation. Scattered radiation from the secondary optical structure () and within the annulus () of the annular meso-optic () is allowed into the annular meso-optic () if an angle of incidence of the scattered radiation exceeds a predetermined incidence threshold. The annular meso-optic () re-directs the scattered radiation to comprise re-directed radiation that is substantially parallel to the axis of revolution (A). 1100. An annular optical device () , comprising:{'b': 1', '11, 'an annular meso-optic () including an annulus () centered about an axis of revolution (A); and'}{'b': 2', '11', '1', '2', '1', '12', '2', '2', '2', '11', '1', '1', '2', '1, 'a secondary optical structure () substantially coaxial within the annulus () of the annular meso-optic (), wherein the secondary optical structure () and the annular meso-optic () are separated by a media () including a media refractive index that is lower than a secondary optical structure refractive index, with the secondary optical structure () being configured to hold a specimen to be radiated by impinging electromagnetic radiation directed into the secondary optical structure () substantially along the axis of revolution (A). wherein scattered radiation from the secondary optical structure () and within the annulus () of the annular meso-optic () is allowed into the annular meso-optic () by the secondary optical structure () if an angle of incidence of the scattered radiation exceeds a predetermined incidence ...

ANALYSIS

Analysis methods and apparatus are provided for inspecting a channel, such as a capillary electrophoresis channel, in a device. Configuration and alignment systems are provided, together with optical systems and temperature control. 1. A method of configuring an optical system for a detection location , the method including: 'considering one or more characteristics of the channel and/or optical system;', 'providing a channel having a detection location for performing an electrophoretic separation on at least a part of a sample;'}configuring the optical system relative to the detection location.2. A method according to in which the optical system is provided in an instrument claim 1 , the channel is provided in a device which can be inserted into and removed from the instrument and the configuring of the optical system is made before the electrophoretic separation.3. A method according to in which the configuring of the optical system is made after one or more other steps have been performed on the device.4. A method according to in which the configuring is with respect to the position of one or more parts of the optical system relative to the channel.5. A method according to in which the position is the position perpendicular to the axis of the channel claim 4 , parallel to the axis along which light is applied to the detection location.6. A method according to in which the position is the position perpendicular to the axis of the channel claim 4 , perpendicular to the axis along which light is applied to the detection location.7. A method according to in which the configuring is with respect to the focus of the light applied to the detection location.8. A method according to in which the configuring is made with reference to the channel claim 1 , the channel is responsive to light and the variation in the detected light with position across the channel is considered.9. A method according to in which one or more components of the optical system are moved and/or the ...

PIEZOELECTRIC MOTOR, DRIVING DEVICE, ELECTRONIC COMPONENT CONVEYING DEVICE, ELECTRONIC COMPONENT INSPECTION DEVICE, PRINTING DEVICE, ROBOT HAND, AND ROBOT

A vibrating body is accommodated in a vibrating body case in a state where both sides of the vibrating body containing a piezoelectric material are sandwiched between buffer portions from a direction intersecting a bending direction of the vibrating body, and the buffer portions are pressed against the vibrating body using a pressing lid through elastic portions. Pressing plates are provided between the buffer portions and the elastic portions to restrict the movement of the pressing plates in a vibration direction of the vibrating body. 1. A piezoelectric motor in which stretching vibration and bending vibration are generated in a vibrating body to move an object , the piezoelectric motor comprising:a vibrating body which contains a piezoelectric material, and has a convex portion protruding from an end surface;a case which accommodates the vibrating body;a pressing elastic body which presses the case in a direction bringing the convex portion of the vibrating body into contact with the object;buffer portions which sandwich both sides of the vibrating body from a direction intersecting a bending direction of the vibrating body in the case, and contain a material having dynamic viscoelasticity;pressing lids which are attached to the case;disk springs which are provided between the pressing lids and the buffer portions, and are compressed by the pressing lids; andpressing plates which are provided between the buffer portions and the disk springs to restrict movement in a stretching direction and a bending direction of the vibrating body.2. The piezoelectric motor according to claim 1 ,wherein the pressing plates are fit into the pressing lids.3. The piezoelectric motor according to claim 1 , wherein the pressing plates have uneven contact surfaces contacting the buffer portions.4. The piezoelectric motor according to claim 1 , wherein the buffer portions have uneven contact surfaces contacting the pressing plates.5. A piezoelectric motor in which stretching vibration ...

Force-Clamp Spectrometer And Methods Of Use

The disclosed subject matter relates to a force-clamp spectrometer that enables operation in constant force mode and allows for automated data acquisition and analysis, using feedback electronics and software. The disclosed subject matter also relates to methods of using the force-clamp spectrometer for the measurement of the dynamics of chemical reactions. The methods may include, but are not limited to, the measurement of the dynamics of substrate folding and unfolding, as well as bond cleavage and bond formation. 1. A force-clamp spectrometer comprising:a cantilever extending from a cantilever chip;a coverslip adjacent to the cantilever chip and mounted on a piezo-electric positioner;a laser configured to focus a laser beam on the cantilever; anda split photodetector configured to detect a reflected beam;wherein the reflected beam is formed after the laser beam is reflected on the cantilever.2. The force-clamp spectrometer of claim 1 , further comprising a camera for monitoring the laser beam focal spot.3. The force-clamp spectrometer of claim 2 , wherein the laser beam is aligned after using information from the camera.4. The force-clamp spectrometer of claim 2 , or claim 2 , further comprising at least one flip mount for rapidly and reproducibly switching positions of the camera and of the piezo-electric positioner.5. The force-clamp spectrometer of any one of to claim 2 , wherein a substrate is suspended between the cantilever and the coverslip.6. The force-clamp spectrometer of claim 5 , wherein the substrate is extended by applying a force to the substrate.7. The force-clamp spectrometer of claim 6 , wherein the extension of the substrate is controlled by the piezo-electric positioner and the force is measured based on bending of the cantilever.8. The force-clamp spectrometer of claim 7 , wherein the bending of the cantilever is monitored by reflecting a laser beam on the cantilever and detecting the reflected beam on the split photodetector.9. The force- ...

Multiwell plate lid for improved optical measurements

A lid for multiwell plates, allowing improved optical measurement of liquid samples within its wells, while mitigating evaporation from said samples, is disclosed. A surface element protrudes from the bottom of the lid into the fluid within a well. The protruding element may be hollow or solid such that light directed into the element may act to capture or direct the beam while preventing backscatter from reaching one or more detectors. The protruding element may direct the beam from the well without requiring the beam to pass through a fluid/air interface. The angle and shape of the lid surfaces and/or light absorbing/blocking colorization may be employed to minimize or eliminate back reflection. Evaporation is controlled by physically capping the well with the lid, either sealing against the face at the top of the well or the inside surface of the well. 1. A well lid for reducing evaporation from , while improving optical measurements of , a liquid sample within a well of a multiwell plate comprisingA) a top surface;B) a bottom surface which rests on, or is seated above, the surface surrounding the opening of said sample containing well; andC) an element protruding from said lid bottom surface and penetrating said liquid sample, wherein said penetrating element is arranged such that it may convey a light beam passing through said sample from below or entering said sample through said element.2. A multi-well lid comprising a plurality of said well lids of arranged to cover a corresponding plurality of wells of said multiwell plate.3. The lid of wherein said protruding element is a hollow tube.4. The lid of wherein said hollow tube absorbs light at the wavelength of said light beam.5. The lid of wherein said protruding element is a solid post.6. The lid of wherein said solid post partially absorbs light at the wavelength of said light beam.7. The lid of wherein said solid post comprisesa. an inner core comprising at least one a flat surface which is intersected by ...

CARTRIDGE AND AUTOMATIC ANALYSIS DEVICE

Provided is a reagent accommodating/measuring cartridge for mixing and reacting a test specimen with a reagent and for measuring the reaction state thereof with the transmitted light, the cartridge comprising a plurality of transmitted-light measurement chambers having different optical path lengths. 1. A reagent accommodating/measuring cartridge for mixing and reacting a test specimen with a reagent and for measuring the reaction state thereof with the transmitted light , the cartridge comprising a plurality of transmitted-light measurement chambers with different optical path lengths.2. The cartridge according to claim 1 , further comprising a specimen-accommodating chamber for accommodating a test specimen claim 1 , a chip-accommodating chamber for accommodating a pipette chip and a tool-accommodating chamber for accommodating a seal-breaking tool.3. The cartridge according to claim 1 , further comprising an identifier for recording information on operational processes including mixing the test specimen with the reagent through outputting measurement results4. The cartridge according to claim 1 , comprising means for displaying reagent information that designates a chamber that gives the highest measurement effect among the plurality of transmitted-light measurement chambers.5. The cartridge according to claim 1 , wherein at least one of the plurality of transmitted-light measurement chambers serves as a reservoir for the reagent or the test specimen.6. The cartridge according to claim 1 , wherein the transmitted-light measurement chamber has transmittance of 70% or higher in the range of 340-800 nm.7. The cartridge according to claim 1 , wherein the transmitted-light measurement chamber is made of cyclic polyolefin.8. The cartridge according to claim 1 , wherein a reagent is placed and sealed in at least one of the plurality of transmitted-light measurement chambers in advance.9. The cartridge according to wherein claim 3 , among the specimen-accommodating ...

Adaptive Optical System Testbed with Karhunen-Loeve Polynomial Based Method for Simulating Atmospheric Turbulence

A system and method for simulating atmospheric turbulence for testing optical components. A time varying phase screen representing atmospheric turbulence is generated using Karhunen-Loeve polynomials and a splining technique for generating temporal functions of the noise factor for each Zernike mode. The phase screen is input to a liquid crystal spatial light modulator. A computer display allows the user to set geometric characteristics, the severity of the turbulence to be simulated, and to select between methods for generating atmospheric turbulence including Karhunen-Loeve polynomials, Zernike polynomials, and Frozen Seeing. 1. An optical testbed system for evaluating the performance of an optical component in a turbulent atmosphere , the system comprising:a computer processor with instructions for generating a time varying wavefront representing atmospheric turbulence and for inputting the time varying wavefront as a sequence of phase screens to a liquid crystal spatial light modulator;a display screen operably connected to the computer processor, wherein in operation, the display screen displays a plurality of alternative methods of generating each phase screen, the methods including a Karhunen-Loeve polynomial based method, a Zernike polynomial based method, and a frozen seeing method; anda user input device for receiving from a user and inputting to the computer processor a user-selected one of the methods.2. The optical testbed system according to claim 1 , said display further adapted to display a Fried parameter r claim 1 , the Fried parameter representing the severity level of turbulence to be simulated claim 1 , and said user input device further configured to receive from a user and to input to the computer processor a user-selected value of the Fried parameter.3. The optical testbed system according to claim 2 , wherein the frozen seeing method includes initially generating a phase screen larger in size than an aperture of the optical system claim 2 , ...

Probe

Optical probe having, independently, an irradiation light guide path for irradiation light and a received light guide path for acquiring radiated light. A first optical fiber configures the irradiation light guide path, and a second optical fiber configures the received light guide path. A condensing lens receives on one surface irradiation light from the first optical fiber and emits same on the other surface, and receives radiated light radiated from the other surface and concentrates same on the side of the first and second optical fibers. The central axis of the exit end of the first optical fiber is deviated relative to the optical axis of the condensing lens, moving reflected light at the condensing lens surface away from, and moving radiated light concentrated by the condensing lens closer to, the center of the light-receiving end of the second optical fiber. 1. A probe having an optical system which illuminates an illumination light to a site of measurement of a biological tissue and receives a radiative light radiated from the site of measurement , and configured so as to measure the radiative light , the prove comprising:a first optical fiber which configures an illumination light guide through which the illumination light is guided and a second optical fiber which configures a receiving light guide through which the radiative light is acquired, the first optical fiber and the second optical fiber being independent from each other;a condensing lens which receives the illumination light output from the first optical fiber and outputs the received illumination light towards the site of measurement and which receives the radiative light radiated from the site of measurement and condenses the received radiative light towards the optical fiber,whereinthe first optical fiber being aligned so as to shift the center axis of the output end of the first optical fiber away from the optical axis of the condensing lens or/and relatively inclined from the optical axis ...

METHOD OF MEASURING CHARACTERISTICS OF SPECIMEN, AND FLAT-PLATE PERIODIC STRUCTURE

The present invention provides a measuring method comprising the steps of holding a specimen on a flat-plate periodic structure, applying a linearly-polarized electromagnetic wave to the periodic structure, and measuring characteristics of the specimen based on change of the electromagnetic wave scattered forward or backward by the periodic structure, wherein the periodic structure is structured such that plural unit structures having the same shape are two-dimensionally and periodically interconnected in a direction of one reference plane, the unit structure has at least one aperture penetrating therethrough in a direction perpendicular to the reference plane, the electromagnetic wave is applied from a direction perpendicular to the reference plane, and the unit structure has a shape that is not mirror-symmetric with respect to an imaginary plane orthogonal to a polarizing direction of the electromagnetic wave. 1. A measuring method comprising:holding a specimen on a flat-plate periodic structure;applying a linearly-polarized electromagnetic wave to the periodic structure:detecting the electromagnetic wave scattered forward or backward by the periodic structure andmeasuring characteristics of the specimen based on a phenomenon that a dip waveform appearing in a frequency characteristic of the forward-scattered electromagnetic wave or a peak waveform appearing in a frequency characteristic of the backward-scattered electromagnetic wave is changed with the presence of the specimen,wherein the periodic structure comprises plural unit structures having the same shape two-dimensionally and periodically interconnected in a direction of one reference plane,the unit structure has at least one aperture penetrating therethrough in a direction perpendicular to the reference plane,the electromagnetic wave is applied from a direction substantially perpendicular to the reference plane, andthe unit structure has a shape that is not mirror-symmetric with respect to an imaginary ...

MULTICHANNEL ANALYTICAL INSTRUMENTS FOR USE WITH SPECIMEN HOLDERS

An analytical instrument may have multiple distinct channels. Such may include one or more illumination sources and sensors. Illumination may be delivered to specific locations of a specimen holder, and returned illumination may be delivered to specific locations of a sensor array. Illumination may first pass a specimen, and a mirror or reflector may then return the illumination past the specimen. Optical splitters may be employed to couple pairs of fiber optics proximate a specimen holder. Such channels may further include a plurality of illumination sources positioned on one side of a specimen holder and a plurality of sensors on the other side. The plurality of sensor may capture image of a specimen and a spectrophotometer may concurrently scan the specimen. A plurality of specimens may be imaged and scanned in a single pass of a plurality of passes. Spherical or ball lenses may be placed in an optical path of the illumination to achieve a desired illumination pattern. 1. A multi-channel analytical instrument , comprising:at least one illumination source disposed on a first side of a specimen receiver having a plurality of wells, the at least one illumination source operable to emit electromagnetic energy through the plurality of wells;at least one sensor disposed on a second side of the specimen receiver, the at least one sensor responsive to electromagnetic energy received from the plurality of wells to produce a signal indicative of at least one characteristic of the electromagnetic energy;a plurality of first optical fibers coupled to the at least one illumination source;a plurality of second optical fibers coupled to the at least one sensor;a plurality of first ball lenses each positioned proximate a respective one of a plurality of positions disposed on the first side of the specimen receiver and spaced from one another along a first dimension of the specimen receiver;a plurality of second ball lenses each positioned proximate a respective one of a ...

Polymeric device suitable for ultraviolet detection

The present invention relates to a flow cell ( 10 ) comprising a fluid inlet ( 16 ) and a fluid outlet ( 18 ) separated by a sample flow-through chamber ( 12 ) comprising at least one UV-transparent window ( 22 ′), wherein the at least one UV-transparent window ( 22 ′) is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible.

ARRANGEMENT OF RETICLE POSITIONING DEVICE FOR ACTINIC INSPECTION OF EUV RETICLES

A reticle positioning apparatus for actinic EUV reticle inspection including a sealed inspection chamber containing a reticle stage for holding a reticle. The reticle stage has a. magnetically suspended upper stage with a long travel in a “y” direction and a magnetically suspended lower stage with a long travel in an “x” direction; and a cable stage chamber isolated from the inspection chamber by a cable chamber wall. The cable stage chamber has a cable stage movable in the “y” direction; and a tube connected at one end to the reticle stage and to the cable stage at the other end, The tube passes from the cable stage through the inspection chamber through a seal in the chamber wail and opening into the cable entry chamber for entry of cables and hoses within the cable stage chamber, which cables and hoses pass through the tube to the reticle stage. 1. A reticle positioning apparatus for actinic EUV reticle inspection comprising:a sealed inspection chamber containing:a reticle stage for holding a reticle, said reticle stage having an upper stage with a long travel in a y direction and a lower stage with a long travel in an x direction; anda cable entry chamber isolated from the inspection chamber by a cable chamber wall, said cable entry chamber having a cable stage movable in the y direction, and a tube connected at a reticle stage end to the reticle stage and within the cable stage chamber to the cable stage, said tube passing from the cable stage through the inspection chamber through a seal in the chamber wall and opening into the cable stage Chamber for entry of cables and hoses within the cable stage chamber, which cables and hoses pass through the tube to the reticle stage,said cable stage being slaved to the reticle stage such that movement of the upper stage in the y direction, at the location of the tube, is detected and provided to signal the cable stage to move the distance of movement of the upper stage in the y direction,2. The reticle positioning ...

Microchip

A microchip including a fluid circuit therein and a specimen inlet for introducing a specimen containing a first component and a second component different in specific gravity from each other into the fluid circuit is provided, in which the fluid circuit includes a specimen measurement unit connected to the specimen inlet and having a prescribed volume for measuring the specimen introduced through the specimen inlet and a separation unit which is a site connected to the specimen measurement unit and having a capacity capable of storing the total amount of the measured specimen, for storing the total amount of the measured specimen and separating the first component and the second component in the stored specimen from each other. 1. A microchip comprising:a first substrate;a second substrate stacked on said first substrate and having a groove on a substrate surface;a fluid circuit including a space defined by said groove and a surface of said first substrate on a side of said second substrate; anda specimen inlet for introducing in said fluid circuit, a specimen containing a first component and a second component different in specific gravity from each other, a specimen measurement unit connected to said specimen inlet and having a prescribed volume for measuring the specimen introduced through said specimen inlet, and', 'a separation unit which is a site connected to said specimen measurement unit and having a capacity capable of storing a total amount of the measured specimen, for storing the total amount of the measured specimen and separating said first component and said second component in the stored specimen from each other., 'said fluid circuit comprising2. The microchip according to claim 1 , whereinsaid separation unit includes an opening for accepting the measured specimen, a first component storage unit for storing the separated first component, and a second component storage unit for storing the separated second component in this order, anda volume of ...

Nanoparticle array with tunable nanoparticle size and separation

The present invention is directed to self-assembled nanoparticle arrays, methods of making the nanoparticle arrays, and methods of using the nanoparticle arrays in spectroscopic methods for detecting targets of interest. The present invention is also directed to a fabrication method for surface-enhanced Raman scattering (SERS) substrates that possess a unique combination of three highly desirable attributes: (a) the SERS substrates can be tuned to match the laser wavelength of operation and maximize the enhancement factor for the particular Raman instrument and analyte in use; (b) the SERS substrates have a highly reproducible enhancement factor over macroscopic sampling areas; and (c) the fabrication method is achieved without resorting to expensive, slow nano-lithography tools. 1. A nanoparticle array comprising:(a) a block copolymer applied to a substrate, wherein the block copolymer comprises at least two polymer blocks, and wherein at least one of polymer blocks has been functionalized; and(b) a plurality of nanoparticles on the block copolymer, wherein the nanoparticles are dispersed on the block copolymer, and wherein the nanoparticles adhere to at least 90% of the block copolymer domains that have been functionalized.2. The nanoparticle array of claim 1 , wherein the block copolymer comprises a first polymer block and a second polymer block.3. The nanoparticle array of claim 2 , wherein the first polymer block is polystyrene.4. The nanoparticle array of claim 2 , wherein the second polymer block is poly(4-vinylpyridine) or poly(2-vinylpyridine).5. The nanoparticle array of claim 2 , wherein the first polymer block is polystyrene and the second polymer block is poly(4-vinylpyridine).6. The nanoparticle array of claim 1 , wherein the array is regular and substantially free of defects.8. The method of claim 7 , further comprising:(d) immersing the nanoparticle array in a growth solution.9. The method of claim 7 , wherein the block copolymer comprises a first ...

ILLUMINATION CHAMBER FOR RAMAN SPECTROSCOPY

The invention relates to a chamber for analyzing a sample by means of Raman spectroscopy, characterized in that the chamber is provided in the form of an opaque parallelepiped having: (a) on one of the vertical walls thereof, a hatch for introducing a sample; (b) on the bottom wall thereof, a first opening, and means () for attaching a light source, for providing excitation radiation, and a lens () enabling the convergence of the excitation radiation so as to define a focal point for the excitation radiation; and (c) a second opening and means for attaching a sensor enabling the Raman scattered light to be detected on a vertical wall or the bottom wall, said attachment means () including adjustment means () for varying said focal point of the excitation radiation along a vertical axis, so as to enable an adjustment of the height of said focal point within the analysis chamber. 110-. (canceled)12. The analysis chamber as claimed in claim 11 , characterized in that the second orifice is combined with the first orifice.13422. The analysis chamber as claimed in claim 11 , characterized in that said fastening means () make it possible to move claim 11 , together claim 11 , both said light source and said lens () allowing for the convergence of the excitation radiation at the focal point.14422. The analysis chamber as claimed in claim 11 , characterized in that said fastening means () make it possible to move said lens () allowing for the convergence of the excitation radiation at the focal point claim 11 , said light source being fixed relative to the bottom wall of the analysis chamber.15422. The analysis chamber as claimed in claim 11 , characterized in that said fastening means () of said light source and of said lens () comprise a light-tight sleeve claim 11 , fastened to the bottom wall of the chamber.168. The analysis chamber as claimed in claim 11 , characterized in that said adjustment means () allowing for the variation of the focal point of the excitation ...

Scattering light source multi-wavelength photometer

The present invention relates to a scattering light source photometer. In particular, the present invention relates to a portable, low cost, multi-wavelength photometer and methods for its use.

OPTO-FLUIDIC SYSTEM WITH COATED FLUID CHANNELS

An image sensor integrated circuit may contain image sensor pixels. A channel for receiving a fluid with samples may be formed on top of the image sensor. The image sensor pixels may form light sensors and imagers. The imagers may gather images of the samples as the fluid passes over the imagers or when the samples from the fluid adhere to the surface above an imager array. A protective coating may be formed on surfaces of the channel to protect the image sensor pixels and integrated circuit from potentially damaging materials in the fluid, samples, or materials provided for evaluating the samples. The protective coating may be a base-resistant material such as a silylating agent. A cover glass may be attached above the image sensor integrated circuit to form a portion of the channel. The protective coating may be formed on surfaces of the cover glass. 1. Apparatus , comprising:an image sensor integrated circuit containing image sensor pixels that form at least one imager;a fluid channel on the image sensor integrated circuit that is configured to receive a sample containing fluid, wherein the at least one imager is located in the channel; anda protective coating on at least one surface of the fluid channel.2. The apparatus defined in claim 1 , further comprising:a barrier layer between the protective coating and image sensor integrated circuit.3. The apparatus defined in claim 2 , further comprising:a bond layer, wherein the bond layer forms portions of sidewalls of the fluid channel.4. The apparatus defined in claim 3 , further comprising a cover glass layer.5. The apparatus defined in claim 4 , wherein a portion of the protective coating is formed on at least one surface of the cover glass layer.6. The apparatus defined in claim 5 , wherein an additional portion of the protective coating is formed on a bottom surface of the fluid channel.7. The apparatus defined in claim 1 , wherein the protective coating comprises a base-resistant silylating material.8. The ...

LIGHTGUIDES TO SIMPLIFY TOTAL EMISSION DETECTION FOR MULTIPHOTON MICROSCOPY

Light collectors for fluorescence microscopy include slab light guides having a specimen volume such as a specimen well configured to retain a specimen. The specimen volume is bounded by a surface of the slab light guide that permits laterally propagating fluorescence to enter the slab light guide and propagate toward a detection or imaging system. Typically, the slab light guide has an elliptical perimeter and the sample volume is situated at a first focus of the elliptical perimeter. A reflector such as a conical reflector is situated at the second focus so as to direct the collected fluorescence to exit the slab light guide. 1. A light collector , comprising:a slab light guide defined by first and second opposing surfaces, the slab light guide including a relief volume situated between the opposing surfaces and configured to receive a specimen, the relief volume bounded by at least one transmissive optical surface that directs received emission from the specimen in the relief volume into the slab light guide, the slab light guide further including a perimeter surface configured to reflect the received emission propagating within the slab light guide to an output surface.2. The light collector of claim 1 , wherein the slab light guide is a hollow slab light guide.3. The light collector of claim 1 , wherein the slab light guide is a solid slab light guide.4. The light collector of claim 1 , wherein the opposing surfaces of the slab light guide are tilted with respect to each other so as to define a tapered slab light guide.5. The light collector of claim 1 , wherein the opposing surfaces of the slab light guide are substantially parallel.6. The light collector of claim 5 , wherein the perimeter surface of the slab light guide is elliptical and the relief volume is situated at a focus of the ellipse.7. The light collector of claim 6 , further comprising an output reflector situated between the opposing surfaces that define the slab light guide and at the second ...

Inspection device

The invention relates to a device for inspecting contact-sensitive planar materials or workpieces, e.g. wafers for the semiconductor industry, solar cells, glasses, FPD substrates, or biologically active substrates for biosensors, as well as materials having contact-sensitive curved surfaces. Said inspection device comprises a support element ( 1 ) for supporting a material ( 3 ) on the top face of the support element ( 1 ), at least one oscillator which is connected to the support element ( 1 ) and the oscillation frequency and amplitude of which are selected in such a way as to keep the material ( 3 ) hovering on the support element ( 1 ), and at least one optical sensor ( 4 ). The support element is made of a light-permeable material, and the optical sensor ( 4 ) is arranged below the support element ( 1 ).

Sample collection and bioluminescent analysis system

Methods and apparatus for evaluating the quality of an environment or process by measuring light emitted from a bioluminescent sample containing ATP, ADP, or alkaline phosphatase. The apparatus comprises a sample collection and analysis system used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The system includes an instrument having a photon detection assembly for use with the sample testing device and one or more probe assemblies that optically cooperate with the instrument. The instrument includes a dark chamber with a reflective interior surface which may be concave or preferably spherical, and a photon detection sensor such as a multi-pixel photon counter sensor. A substantially transparent portion of the probe assembly, and liquid contained therein, focus bioluminescence toward the photon detection sensor.

SYSTEMS AND METHODS FOR INDIVIDUALLY TRAPPING PARTICLES FROM AIR AND MEASURING THE OPTICAL SPECTRA OR OTHER PROPERTIES OF INDIVIDUAL TRAPPED PARTICLES

Embodiments of the present invention are directed to systems and methods for continuously sampling particles from air. In one embodiment, a system for continuously sampling particles from air may include: an airflow system configured to continuously draw air including airborne particles into the system; a photophoretic trap that uses photophoretic forces of a laser beam to trap one or more of the airborne particles from the drawn air; a measurement device configured to measure one or more properties of the trapped one or more airborne particles; and a controller configured to repeatedly trap, measure and release one or more airborne particles. 1. A system for continuously sampling particles from air comprising:an airflow system configured to continuously draw air including airborne particles into the system;a photophoretic trap that uses photophoretic forces of a laser beam to trap one or more of the airborne particles from the drawn air;a measurement device configured to measure one or more properties of the trapped one or more airborne particles; anda controller configured to repeatedly trap, measure and release one or more airborne particles.2. The system of claim 1 , wherein the photophoretic trap is configured to trap and hold only about one particle at any one time.3. The system of claim 1 , wherein one laser is used to trap the particle and to generate one or more emissions of claim 1 , and/or elastic scattering by claim 1 , the trapped one or more airborne particles.4. The system of claim 1 , further comprising: a particle detector configured to detect an airborne particle approaching and/or within the photophoretic trap.5. The system of claim 1 , further comprising: at least one separate laser configured to excite emissions of the trapped one or more airborne particles.6. The system of claim 1 , wherein the measurement device is configured to measure one or more of: Raman spectra claim 1 , Raman emission in one or more wavelength bands claim 1 , laser- ...

INTEGRATED SENSORS

Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a flexible substrate, and an array of spaced apart sensing members formed on a surface of the flexible substrate. Each of the spaced apart sensing members includes a plurality of polygon assemblies. The polygon assemblies are arranged in a controlled pattern on the surface of the flexible substrate such that each of the plurality of polygon assemblies is a predetermined distance from each other of the plurality of polygon assemblies, and each of the plurality of polygon assemblies including collapsible signal amplifying structures controllably positioned in a predetermined geometric shape. 1. An integrated sensor , comprising:a flexible substrate; andan array of spaced apart sensing members formed on a surface of the flexible substrate, each of the spaced apart sensing members including a plurality of polygon assemblies arranged in a controlled pattern on the surface of the flexible substrate such that each of the plurality of polygon assemblies is a predetermined distance from each other of the plurality of polygon assemblies, and each of the plurality of polygon assemblies including collapsible signal amplifying structures controllably positioned in a predetermined geometric shape.2. The integrated sensor as defined in wherein the predetermined geometric shape is a trigon claim 1 , a tetragon claim 1 , a pentagon claim 1 , a hexagon claim 1 , or a heptagon.3. The integrated sensor as defined in wherein the controlled pattern of the plurality of polygon assemblies includes an N×M array of the polygon assemblies claim 1 , wherein N and M are individually chosen from 2 to 2000.4. The integrated sensor as defined in wherein the collapsible signal amplifying structures include metal-capped polymer nano-pillars claim 1 , metal-coated polymer nanoflakes claim 1 , metal-coated mushroom-shaped nano-structures claim 1 , or metal-ringed polymer nano-pillars.5. The integrated ...

Observation apparatus capable of detecting distal end position of insertion module using external light

An insertion module inserted into inside of an observed object includes a light-source light emitting module, around its distal end, configured to emitted light from a light source and a detector, provided close to the distal end, configured to detect a light quantity of incident visible light. A controller controls the light source such that a null signal is transmitted from the light-source light emitting module, the null signal being characteristic for detection of the position of the distal end and obtained by making at least light of a predetermined wavelength region have an absence of visible light. The detector performs detecting operation in a period in which the null signal is transmitted. A determination module performs determination relating to the position of the distal end, based on detection information outputted by the detector.

FIBRE OPTIC MONITORING INSTALLATION AND METHOD

The invention relates to installations for fibre optic monitoring of articles, and apparatus and methods for forming such installations, including a modular system and components for forming a fibre optic monitoring installation. Applications of the invention include the monitoring of vessels, chambers, and fluid conduits in industrial processing plants, and the invention has particular application to monitoring large vessels, for example temperature monitoring of vessels used in catalytic reforming processes. Convenient installation on or removal from the article being monitored is achieved by providing a support structure for the fibre optic length, which presents the fibre optic length in a preconfigured orientation suitable for monitoring the article. In a particular embodiment of the invention, the fibre optic length is disposed on a panel in a plurality of dense spiral patterns. 1. A fibre optic monitoring installation comprising:an article having an outer surface to be monitored;a fibre optic support structure arranged to support a fibre optic length, wherein the support structure defines a monitoring area which corresponds to a part of a surface of the article, and the fibre optic length is arranged in a predetermined pattern or orientation over the monitoring area defined by the support structure;means for locating the fibre optic support structure in relation to the article such that, in use, the fibre optic length is sensitive to a condition of the surface of the article; andfibre optic instrumentation coupled to the fibre optic length.2. The fibre optic monitoring installation according to claim 1 , wherein the support structure is configured for attachment of the fibre optic length to the support structure before the support structure is located in relation to the article to be monitored.3. The fibre optic monitoring installation according to claim 1 , wherein the support structure is configured to be located in relation to the article to form an in ...

IMAGING APPARATUS

An imaging apparatus, comprising a holder that holds a specimen container carrying a biological specimen, an imager that images the specimen in the specimen container, a sterilizer that supplies a drug or electromagnetic waves having a sterilization effect to the holder, and a controller that performs a sterilization process of supplying the drug or the electromagnetic waves to the holder by controlling the sterilizer at least either before or after imaging the specimen by the imager. 1. An imaging apparatus , comprising:a holder that holds a specimen container carrying a biological specimen;an imager that images the specimen in the specimen container;a sterilizer that supplies a drug or electromagnetic waves having a sterilization effect to the holder; anda controller that performs a sterilization process of supplying the drug or the electromagnetic waves to the holder by controlling the sterilizer at least either before or after imaging the specimen by the imager.2. The imaging apparatus according to claim 1 , further comprising a chamber that forms a specimen housing space capable of housing the specimen container claim 1 , wherein the holder is provided in the specimen housing space and the sterilizer supplies the drug or the electromagnetic waves to the specimen housing space.3. The imaging apparatus according to claim 2 , wherein at least a part of a wall surface of the chamber serves as a transparent window having light permeability and the imager images the specimen held in the specimen container housed in the specimen housing space through the transparent window from outside of the specimen housing space.4. The imaging apparatus according to claim 3 , wherein the sterilizer includes an electromagnetic wave irradiator provided outside the specimen housing space and configured to irradiate electromagnetic waves to the specimen housing space through the transparent window.5. The imaging apparatus according to claim 2 , wherein the sterilizer supplies gas or ...

APPARATUS AND METHOD FOR INCREASING COLLECTION EFFICIENCY IN CAPILLARY BASED FLOWCYTOMETRY

In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths. 1. A light collection system for use in a particle analyzing apparatus which comprises an analyzing region for analyzing particles , said particles fluoresce or are labeled with substances that fluoresce upon illumination of light , comprising:a first collection lens at a first side of the analyzing region;a second collection lens at a second side of the analyzing region opposite to the first side; anda first reflection element arranged adjacent to the first collection lens, the first reflection element being configured to back-reflect fluorescent light of one or more wavelengths collected by the first collection lens.2. The light collection system of wherein the first reflection element is further configured to transmit fluorescent light of wavelength(s) that is (are) different from the wavelengths reflected by the first reflection element.3. The light collection system of further comprising a second reflection element arranged adjacent to the second collection lens claim 2 , the second reflection element being configured to back-reflect fluorescent light of one or more wavelengths that are transmittable by the first reflection element claim 2 , and transmit fluorescent light of wavelength(s) that are ...

IMMERSION LIQUID RETAINER, OBSERVED PORTION FIXING APPARATUS AND MICROSCOPE

An immersion liquid retainer is an immersion liquid retainer used for an observation made with a microscope including an immersion objective. The immersion liquid retainer includes a fixing part in which a first penetration hole for viewing an observed portion of a specimen is formed and which is fixed to the specimen, and an immersion liquid retaining part where a concave part that has a bottom surface configured with a transparent flat plate and is intended to retain an immersion liquid is formed. The immersion liquid retaining part is joined to the fixing part or formed integrally with the fixing part so that the transparent flat plate covers the first penetration hole. 1. An immersion liquid retainer used for an observation made with a microscope including an immersion objective , comprising:a fixing part in which a first penetration hole for viewing an observed portion of a specimen is formed and which is fixed to the specimen; andan immersion liquid retaining part where a concave part that has a bottom surface configured with a transparent flat plate and is intended to retain an immersion liquid is formed, whereinthe immersion liquid retaining part is joined to the fixing part or formed integrally with the fixing part so that the transparent flat plate covers the first penetration hole.2. An observed portion fixing apparatus , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the immersion liquid retainer according to ; and'}a support part, provided on a stage where the specimen is placed, for supporting the immersion liquid retainer.3. The observed portion fixing apparatus according to claim 2 , further comprisinga suction part for suctioning a gas within a space enclosed by the fixing part, the specimen, and the transparent flat plate, whereinthe suction part suctions the gas within the space via a second penetration hole formed in the immersion liquid retainer.4. The observed portion fixing apparatus according to claim 3 , whereinthe second ...

ANALYZER AND AGITATING APPARATUS

An analyzer comprises a container supplying unit which supplies a container, an agitating unit which agitates liquid in the container, and a measurement unit which performs a measurement using the liquid agitated by the agitating unit. The agitating unit comprises a base which is configured to move relative to the container supplying unit, a driving source which is mounted on the base, a container catcher which is configured to catch the container at one side, a transmitting member which transmits the power of the driving source to the other end side of the container catcher, and a supporting member which supports the container catcher at a position between one end and the other end of the container catcher. 1. An analyzer comprising:a container supplying unit which supplies a container;an agitating unit which agitates liquid in the container; anda measurement unit which performs a measurement using the liquid agitated by the agitating unit,wherein the agitating unit comprises:a base which is configured to move relative to the container supplying unit;a driving source which is mounted on the base;a container catcher which is configured to catch the container at one side;a transmitting member which transmits the power of the driving source to the other end side of the container catcher; anda supporting member which supports the container catcher at a position between one end and the other end of the container catcher.2. The analyzer of claim 1 , wherein the container catcher is configured so as to be disposed at a catching position to catch the container in conjunction with the movement of the base when the catcher catches a container following a condition in which the catcher does not catch a container.3. The analyzer of claim 1 , wherein the transmitting member is configured to move in accordance with the operation of the driving source claim 1 , and the transmitting member is configured to support the container catcher regularize the orientation of the container ...

Method and System for Tilt and Height Control of a Substrate Surface in an Inspection System

A system for substrate tilt and focus control in an inspection system includes a dynamically actuatable substrate stage assembly including a substrate stage for securing a substrate; a tilt-height detection system including: a height detection sub-system and a tilt detection sub-system. The system further includes a first actuator configured to selectably actuate the substrate along a direction perpendicular to the surface of the substrate at a location of the substrate stage assembly; and an additional actuator configured to selectably actuate the substrate along a direction substantially perpendicular to the surface of the substrate at an additional location of the substrate stage assembly; and a MIMO tilt-focus controller communicatively coupled to the height detection sub-system, the tilt detection sub-system, the first actuator and the additional actuator. 1. A system for tilt and focus control in an inspection system , comprising:a dynamically actuatable substrate stage assembly including a substrate stage for securing a substrate; a height detection sub-system configured to measure height of a surface of the substrate at a position of inspection of the substrate surface, the illumination emanating from an illumination source of an inspection system; and', 'a tilt detection sub-system configured to measure tilt of the substrate disposed on the substrate stage;, 'a tilt-height detection system includinga first actuator operably coupled to the substrate stage assembly at a first location of the substrate stage assembly and configured to selectably actuate the substrate along a direction substantially perpendicular to the surface of the substrate at the first location of the substrate stage assembly;an additional actuator operably coupled to the substrate stage assembly at an additional location of the substrate stage assembly and configured to selectably actuate the substrate along a direction substantially perpendicular to the surface of the substrate at the ...

Optics Sensor Structure For Detecting Water Or Oil Leakage Inside A Conservator Having A Bladder Or Membrane

Optical sensor structure senses the presence of liquid in a sealed conservator tank. The sensor structure includes a sensor head having a body with first and second opposing ends, a plurality of perforations through the body and spaced between the first and second ends, and a mirror disposed at the second end. The perforations are constructed and arranged to receive and hold fluid therein. The sensor head is constructed and arranged to rest on a surface of a bladder. The sensor structure includes a light source, a first fiber optic cable between the light source and the first end of the body, a light detector, and a second fiber optic cable between the light detector and the first end of the body. The amount of light received by the light detector is reduced when liquid, instead of air, is in at least some of the perforations in the body. 111.-. (canceled)12. A method of detecting the presence of liquid on an air side of a bladder disposed in a conservator tank for a transformer oil preservation type system , the bladder isolating oil from air and having a first surface exposed to the air and an opposing , second surface exposed to the oil , the method comprising the steps of:placing an optical sensor head on the first surface of the bladder,providing a source of light to the sensor head,determining a normal condition when no liquid is in contact with the sensor head by detecting a certain amount of light exiting the sensor head, anddetermining a malfunction condition when liquid is in contact with the sensor head by detecting an amount of light, less than the certain amount of light, exiting the sensor head.13. The method of claim 12 , wherein the sensor head includes a body having first and second opposing ends claim 12 , a plurality of perforations through the body and spaced between the first and second ends claim 12 , and a mirror disposed at the second end claim 12 , the perforations being constructed and arranged to receive and hold liquid therein claim 12 , ...

SYSTEM AND METHOD FOR REMOVING SURFACE PARTICLES FROM AN OBJECT

A fluid jet may be delivered by an outlet to dislodge particles from an object, such as a person. An image sensor may track particles dislodged from the object. The image sensor may also be configured to analyze the dislodged particles in flight. The dislodged particles may also be captured for further analysis. The image sensor may provide feedback for adjusting an impact location of the fluid jet and/or for adjusting the positioning of a particle capture mechanism. A distraction mechanism may distract the object and/or mask the sound of the fluid jet to prevent the object from realizing the fluid jet has been delivered. Additional substances and/or tags may be delivered by the outlet to the object and/or particles. 1. A system for tracking surface particles dislodged from an object , the system comprising:a first outlet configured to deliver a dislodging fluid jet to the object; andan image sensor configured to track one or more particles dislodged from the object.2. The system of claim 1 , further comprising a light source configured to irradiate the one or more dislodged particles for tracking.3. The system of claim 2 , wherein the light source is further configured to be steerable to selectively irradiate the one or more dislodged particles.4. The system of claim 2 , wherein the image sensor is configured to track the one or more dislodged particles by tracking a fluorescence pattern of the one or more dislodged particles.5. The system of claim 2 , wherein the image sensor is configured to track the one or more dislodged particles by tracking a light scattering pattern of the one or more dislodged particles.6. The system of claim 1 , wherein the image sensor is further configured to analyze identifying characteristics of the one or more dislodged particles.7. The system of claim 6 , wherein the image sensor is configured to analyze electromagnetic radiation from the one or more dislodged particles.89.-. (canceled)10. The system of claim 7 , wherein the image ...

ANALYTICAL SYSTEM WITH CAPILLARY TRANSPORT

An analytical system is disclosed. The analytical system includes a storage container configured to store a plurality of capillaries. It also includes a gripper configured to receive at least one of the plurality of capillaries, and move the at least one capillary so that an end of the capillary contacts a sample in a sample container and draws the sample in the capillary. The system also includes a reader configured to detect a signal from the sample in the capillary. 1. An analytical system comprising:a storage container configured to store a plurality of capillaries;a gripper configured to receive at least one of the plurality of capillaries, wherein an end of the capillary is configured to contact a sample in a sample container and draws the sample in the capillary; anda reader configured to detect a signal from the sample in the capillary.2. The analytical system of further comprising:a capillary drop door disposed underneath the storage container.3. The analytical system of wherein the storage container is in a capillary dispenser unit claim 1 , and a bottom of the storage container comprises a sloped floor claim 1 , and wherein the analytical system further comprises:a capillary stop comprising a bottom surface, wherein a distance forming a space between the sloped floor and the bottom surface is approximately equal to an outer diameter of a capillary disposed between the sloped floor and the bottom surface; anda capillary drop lever, wherein the capillary drop lever is configured to release one capillary at a time from the capillary dispenser unit.4. The analytical system of further comprising:a transport bridge disposed between the reader and the storage container, the transport bridge configured to transport capillaries proximate to the reader.5. The analytical system of further comprising:a rotator comprising a slot, wherein the slot is configured to receive one capillary and is configured to receive a capillary in a horizontal position, and change the ...

FLOW CYTOMETER NOZZLE TIP

A nozzle tip formed from a cylindrical body defining a longitudinal axis and a frustoconical body adjoining the cylindrical body on the longitudinal axis. The cylindrical body may be in fluid communication with the frustoconical body. The frustoconical body may end in a flat surface with a nozzle exit orifice which is transverse to the longitudinal axis. There may be a cutout at the edge of the frustoconical body and the flat surface. The flow cytometer system may also include a source of electromagnetic radiation for producing a beam incident upon the fluid stream and the particles and a detector for detecting light emitted or reflected from the particles within the fluid stream in response to the beam. 1. A flow cytometer system comprising:a nozzle assembly for producing a fluid stream with particles, the nozzle assembly comprising a nozzle tip formed from a cylindrical body defining a longitudinal axis and a frustoconical body adjoining the cylindrical body on the longitudinal axis which is in fluid communication with the cylindrical body, wherein the frustoconical body ends in a flat surface transverse to the longitudinal axis which has a nozzle exit orifice, and wherein the frustoconical body further comprises a cutout at the edge of the flat surface and the frustoconical body;a source of electromagnetic radiation for producing a beam incident upon the fluid stream and the particles; anda detector for detecting light emitted or reflected from the particles within the fluid stream in response to the beam.2. The flow cytometer of claim 1 , wherein the chamfered nozzle tip comprises an interior surface and an exterior surface.3. The flow cytometer of claim 2 , wherein the nozzle tip comprises an orienting nozzle tip.4. The flow cytometer of claim 3 , wherein the interior surface of the nozzle tip comprises an orienting geometry.5. The flow cytometer of claim 4 , wherein the interior surface of the nozzle tip transitions from a circular cross section to an ...

HIGH-DENSITY ARRAY CHIPS WITH SYNCHRONOUS TRACKS

An array chip design is provided where the chip includes a field region arranged with sites according to a first pitch and at least one track region having a one-dimensional site pattern arranged according to a second pitch that is less dense and is an integer multiple of the first pitch so that observation through pixel-based sensors using one-dimensional quad-cell averaging can be applied in the track region, thereby to attain alignment of the chip to pixel-based optical instrumentation with a higher density of sites. 1. A chip for observation of discrete elements in a high-density array comprising:a substrate comprising at least one field region and at least one track region;experiment sites disposed in a first patterned array in the at least one field region, the first patterned array being defined by a first pitch on a scale comparable to an object space pixel; andalignment sites disposed in a second patterned array in the at least one track region, the second patterned array being defined by a second pitch along a single dimension;wherein the second pitch differs from the first pitch by an integer multiple in order to permit quad-cell based alignment.2. The chip of claim 1 , wherein the at least one field region has a density of one object space pixel per one experiment site.3. The chip of claim 1 , wherein the at least one field region has a density of two object space pixels per one experiment site claim 1 , the experiment sites being arranged in a checkerboard pattern.4. The chip of claim 1 , wherein the at least one field region has a density of four object space pixels per one experiment site.5. The chip of claim 1 , wherein said alignment sites are configured to support biochemical experiments.6. The chip of claim 1 , wherein selected ones of the alignment sites are omitted in accordance with a preselected pattern.7. The chip of claim 1 , wherein selected ones of the alignment sites are8. The chip of claim 1 , wherein areas of the substrate claim 1 , ...

OPTICAL INSTRUMENTS

An optical instrument () has a drop-supporting surface for receiving a droplet () of liquid with a cover () mounted on the housing () which receives a light source and provides communication between the light source () and the inner surface of the cover. A loading aperture () extending through the cover permits access to the drophead when the cover is in a first rotational loading position, and the cover may be rotated to a measurement position in which the light source is positioned to illuminate the drop-supporting surface. A positioning mechanism provided between the cover an the housing engages the cover when it reaches the measurement position and thereby ensures that the light source and drop-supporting surface are maintained in fixed spaced-apart relationship. 1. An optical instrument comprising:a housing having a drop-supporting surface for receiving a droplet of liquid;a cover having outer and inner surfaces, the cover being mounted on the housing such that the inner surface faces the drop-supporting surface of the housing;a connector provided on the cover for receiving a light source and providing communication between the light source and the inner surface of the cover;the cover having a loading aperture extending therethrough, the aperture being spaced apart from said connector;a mounting provided between said cover and said housing permitting relative rotational movement between the cover and the housing about an axis between measurement and loading positions, wherein when in said measurement position the connector is positioned relative to the drop-supporting surface such that a light source received in said connector is positioned to illuminate the drop-supporting surface, and when in said loading position the loading aperture is positioned to provide access to the drop-supporting surface;a positioning mechanism provided between said cover and said housing to engage said cover when it reaches said measurement position and thereby ensure that the light ...

Spatially resolved imaging of opto-electrical property variations

Systems and methods for opto electric properties are provided. A light source illuminates a sample. A reference detector senses light from the light source. A sample detector receives light from the sample. A positioning fixture allows for relative positioning of the sample or the light source with respect to each other. An electrical signal device measures the electrical properties of the sample. The reference detector, sample detector and electrical signal device provide information that may be processed to determine opto-electric properties of the same.

OPTICAL MEASURING APPARATUS AND OPTICAL MEASURING MICROCHIP

There is provided an optical measuring apparatus including a control unit that compensates detection light generated from a reaction area in a microchip, based on optical information from a detection-light-quantity calibration area. 1. An optical measuring apparatus comprising:a control unit that compensates detection light generated from a reaction area in a microchip, based on optical information from a detection-light-quantity calibration area.2. The optical measuring apparatus according to claim 1 , wherein the detection-light-quantity calibration area is provided at an exterior and/or an interior of the microchip.3. The optical measuring apparatus according to claim 2 , wherein the optical measuring apparatus compensates the detection light claim 2 , based on a first distance between the detection-light-quantity calibration area and a detection optical system and a second distance between the reaction area and the detection optical system claim 2 , the first distance being based on the optical information.4. The optical measuring apparatus according to claim 3 , wherein the optical measuring apparatus further compensates the detection light claim 3 , based on a planar distance between the detection-light-quantity calibration area and the reaction area.5. The optical measuring apparatus according to claim 2 , wherein a plurality of the detection-light-quantity calibration areas are provided in a stair-like manner claim 2 , and the optical measuring apparatus compensates the detection light generated from the reaction area in the microchip claim 2 , based on a plurality of pieces of the optical information from the detection-light-quantity calibration areas.6. The optical measuring apparatus according to claim 3 , wherein the detection-light-quantity calibration area contains a detection-light-quantity calibration substance that is in a solid form claim 3 , semisolid form claim 3 , or liquid form.7. The optical measuring apparatus according to claim 6 , wherein ...

Terahertz Wave Measurement Device and Method

The base plate is transmissive to terahertz waves, and a sample is disposed at the base plate. In the conductive periodic structure, plural transmission portions that transmit terahertz waves are arrayed with a predetermined period. The conductive periodic structure is disposed apart from a position at which the sample is disposed. The waveguide includes a total reflection surface provided at a boundary face with the conductive periodic structure. The total reflection surface totally reflects incident terahertz waves, and the waveguide guides incident terahertz waves toward the total reflection surface. The magnitudes of one or more of a distance between the position at which the sample is disposed and the conductive periodic structure, a property of the base plate, and the predetermined period are set such that a dip showing a characteristic absorption is formed in a predetermined frequency region of a spectrum of terahertz waves.

Microvessels, microparticles, and methods of manufacturing and using the same

A plurality of isolated microvessels including a plurality of encoded microvessels each having a microbody and a reservoir core. The microbody is configured to separate a biological or chemical substance in the reservoir core from an ambient environment surrounding the microbody. The microbody includes a transparent material that at least partially surrounds the reservoir core and facilitates detection of an optical characteristic of the substance within the reservoir core. The microbody of each microvessel includes an identifiable code that distinguishes individual microvessels of the plurality of encoded microvessels from each other. The plurality of isolated microvessels also includes a plurality of compartments each configured to separate individual microvessels of the plurality of encoded microvessels from each other.

Hydrodynamic Treadmill: A Tracking Device to Study Biotic/Abiotic Systems in Gravitational and Hydrodynamic fields

An annular fluid-filled sample chamber is used to provide observation of unbounded motion of objects in the fluid. Rotation of the sample chamber is under automatic control to compensate for azimuthal motion of the object, thereby keeping the object in a fixed field of view of an optical observation system. Further motion control can be provided in the radial and focus directions, which can be used to provide full 3D tracking of objects as they move in the fluid. An important application of this work is to observation and tracking of objects that move up or down in the fluid with respect to gravity. 1. Apparatus for observing unbounded motion of an object in a fluid , the apparatus comprising:an optically transparent sample chamber configured as an annulus filled with a fluid; andan azimuthal control system configured to rotate the sample chamber to compensate for azimuthal motion of an object in the fluid such that the object continuously remains visible within a predetermined field of view.2. The apparatus of claim 1 , wherein the apparatus is configured such that the azimuthal motion of the object is substantially up or down with respect to an ambient gravitational field.3. The apparatus of claim 2 , further comprising a system for varying environmental parameters of the fluid as a function of a virtual depth as the virtual depth varies according to azimuthal motion of the object.4. The apparatus of claim 3 , wherein the environmental parameters include one or more parameters selected from the group consisting of: optical intensity claim 3 , optical spectrum claim 3 , optical polarization claim 3 , nutrient concentration claim 3 , oxygen concentration claim 3 , chemical species concentration claim 3 , pressure claim 3 , electric field direction and intensity claim 3 , and magnetic field direction and intensity.5. The apparatus of claim 2 , wherein a set-point for an azimuthal position of the object is selected to cause the object to move radially within the ...

Outer part for a device and device

An outer part for a device which is attachable thereto as a housing and/or an attachment part, a first reflective surface and a second reflective surface being formed on the outer part so that at least one signal emitted by an optical and/or acoustic source is directly or indirectly deflectable onto at least one detector surface of an optical and/or acoustic detector, an optical path being configured as a cavern or continuous recess in the outer part or as a depression of a boundary surface of the outer part, the optical path having at least one opening via which at least one substance is transferable into the optical path, and the at least one signal being deflectable into the optical path to the second reflective surface which is formed at a second end of the optical path with the first reflective surface at a first end of the optical path. 1. An outer part for a device which is attachable to at least one further component of the device as a housing part and/or as an attachment part , comprising:an outer part arrangement, wherein a first reflective surface and a second reflective surface is formed on the outer part so that at least one optical and/or acoustic signal emitted by an optical and/or acoustic source of the device having the attached outer part is deflectable onto the second reflective surface with the aid of the first reflective surface, and the at least one optical and/or acoustic signal reflected off the first reflective surface is deflectable with the aid of the second reflective surface so that the at least one optical and/or acoustic signal is directly or indirectly deflectable onto at least one detector surface of an optical and/or acoustic detector of the device having the attached outer part;wherein an optical path is configured as a cavern or a continuous recess in the outer part arrangement, or as a depression of a boundary surface of the outer part arrangement, and has at least one opening via which at least one substance is transferable into ...

WELL PLATE AND METHOD OF USING THE SAME

There is provided a well plate including a plate and a well which is opened in an upper surface of the plate, wherein the well includes a flat bottom surface part and a circumferential wall part rising upward from the circumferential edge of the bottom surface part; the circumferential wall part has a stepped part in the circumferential direction at an arbitrary height position; an upper circumferential wall part, which is located above the stepped part in the circumferential wall part, is larger in a cross sectional area than a lower circumferential wall part located below; and the stepped part indicates the lower limit of the liquid level height of a liquid sample contained in the well. 1. A well plate comprising a plate and a well which is opened in an upper surface of the plate ,whereinthe well includes a flat bottom surface part and a circumferential wall part rising upward from the circumferential edge of the bottom surface part,the circumferential wall part has a stepped part in the circumferential direction at an arbitrary height position,an upper circumferential wall part, which is located above the stepped part in the circumferential wall part, is larger in a cross sectional area than a lower circumferential wall part located below, andthe stepped part indicates the lower limit of the liquid level height of a liquid sample contained in the well.2. The well plate according to claim 1 , wherein the stepped part is provided at a height position such that the volume of the lower circumferential wall part is ½ or less relative to the volume of the well claim 1 , in the circumferential wall part.3. The well plate according to claim 1 , wherein the stepped part has light blocking property of blocking light having a wavelength within a visible light range.4. The well plate according to claim 1 , wherein the lower circumferential wall part rises almost vertically to the bottom surface part or in a tapered manner toward the opening direction.5. The well plate ...

PIPETTE TIP SYSTEM, DEVICE AND METHOD OF USE

This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A measuring system is provided having: a base unit with a means for locating a pipette tip; a pipette tip designed to interact with the base unit for purposes of accurate pipette tip positioning; at least one light supplying unit positioned to supply light to a liquid sample in the pipette tip and at least one light collecting unit positioned to collect light from a liquid sample in the pipette tip. 1. A device comprising: a base unit configured to receive a pipette tip , said base unit configured to provide structural alignment of the pipette tip between a light supplying unit and a light collecting unit mounted to the base unit , wherein said base unit has an inner profile defining an accommodating space , wherein said inner profile of the base unit is configured to physically interact with an outer profile of a component unit configured to secure a pipette tip.2. The device of further comprising: a pipette tip adapted to be to attached to a pipette claim 1 , wherein said pipette tip includes at least one optics component positioned in at least one observation zone between the light supplying unit and the light collecting unit.3. The device of further comprising a pipette tip adapted to be attached to a pipette claim 1 , wherein said pipette tip is configured to have at least one optically clear flat area.41. The device of further comprising a pipette tip adapted to be attached to a pipette claim 1 , wherein said pipette tip is configured to have at least one flexible area contacted by at least one light supplying unit to change the path length through a liquid sample in said pipette tip.51. The device of further ...

Portable Moisture Analyzer for Natural Gas

Methods, devices, and systems are provided for analyzing the moisture content in natural gas. In one embodiment, a portable moisture analyzer system is provided and can include a moisture analyzer and a housing. The moisture analyzer can include a tunable diode laser absorption spectrometer (TDLAS) and a natural gas sample conditioning system. The TDLAS can be configured to detect water vapor content within a natural gas sample. The sample conditioning system can be in fluid communication with the TDLAS and can be configured to condition at least one of temperature, flow rate, and pressure of a natural gas sample. The housing can be configured to receive the moisture analyzer therein and to protect the moisture analyzer from vibration and/or shock. 1. A portable moisture analyzer system , comprising: a moisture sensor configured to detect water vapor content within a gas sample and output a moisture signal including data representing the detected water vapor content,', 'a fluid conduit network in fluid communication with the moisture sensor and extending between an inlet and an outlet, wherein the fluid conduit network is configured to receive, at the inlet, a flow of a raw gas sample from a sample gas source at a raw flow rate;', 'a sample conditioning system including one or more conditioning devices positioned along the fluid conduit network between the inlet and the moisture sensor, wherein the conditioning devices are configured to adjust at least one of pressure and flow rate of a raw gas sample flow received by the fluid conduit network and filter particulate and liquid contaminants from the raw gas sample flow to provide a conditioned gas sample flow to the moisture sensor, and', 'an instrument panel including opposed first and second sides, wherein each of the conditioning devices and a portion of the fluid conduit network are mounted on the first side of the instrument panel,, 'a moisture analyzer including,'}an inner housing defining one or more inner ...

DRY SLIDE ASSAY USING REDUCED READING WINDOW

The present disclosure is directed to a method and apparatus for performing an assay on a dry slide or other solid media using a reduced reading window. In an embodiment, method of performing at least one assay comprises obtaining an image of a fluid sample located on a dry slide, positioning a reading window to correspond to an area of the fluid sample in the image, determining an interference area within the reading window based on light intensity, reducing the reading window to eliminate the interference area from the reading window, and performing at least one assay using the reduced reading window. 1. A method of performing at least one assay comprising:obtaining, in a processor of a control unit, an image of a fluid sample located on a dry slide;positioning, via the processor of the control unit, a reading window to correspond to an area of the fluid sample in the image;determining, via the processor of the control unit, an interference area within the reading window based on light intensity;reducing, via the processor of the control unit, the reading window to eliminate the interference area from the reading window; andperforming, via the control unit, at least one assay using the reduced reading window.2. The method of claim 1 , wherein reducing the reading window includes reducing the reading window to a predetermined shape.3. The method of claim 2 , wherein reducing the reading window includes reducing the reading window to a crescent shape.4. The method of claim 3 , wherein reducing the reading window includes reducing the reading window from a circular shape to the crescent shape.5. The method of claim 1 , wherein the reading window has an initial area claim 1 , and wherein reducing the reading window includes reducing the reading window to a predetermined area less than the initial area.6. The method of claim 1 , which includes dispensing a washing fluid onto the fluid sample on the dry slide claim 1 , wherein the interference area is caused by the ...

MULTIWELL MICROELECTRODE ARRAY WITH OPTICAL STIMULATION

An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well. 1. An electro-optical stimulation and recording system , comprising:a substrate;a plurality of wells coupled to the substrate;a plurality of electrode arrays, each of the electrode arrays being positioned at a base of one of the plurality of wells, wherein each respective electrode array comprises a plurality of electrodes, each individual electrode of the respective electrode array being configured to collect an electric signal associated with a respective portion of one of the plurality of wells,a plurality of light-emitting element sets, each of the plurality of light-emitting element sets corresponding to one of the plurality of wells and configured to deliver optical stimulation to at least a portion of one of the plurality of wells.2. (canceled)3. The system of claim 1 , wherein each individual electrode of the respective electrode array is further configured to deliver electric stimulation to a respective portion of one of the plurality of wells.4. The system of claim 1 , wherein each of the plurality of electrode arrays further comprises at least one electrode configured to deliver electric stimulation to at least a portion of one of the plurality of wells.5. The system of claim 1 , wherein at least a first of the plurality of light-emitting element sets is configured to be illuminated independently of at least a second of the plurality of light-emitting element ...

DYNAMIC HIGH-SPEED HIGH-SENSITIVITY IMAGING DEVICE AND IMAGING METHOD

Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed. 112-. (canceled)13. A method for generating one or more time-independent images corresponding to an object , comprising:(a) providing (1) a structured optical pattern comprising a plurality of regions with different optical characteristics, which structured optical pattern is provided by at least using an optical system with a structured lighting pattern or a structured detecting system; and (2) a detector comprising at least one pixel, wherein said detector is in optical communication with at least said structured optical pattern;(b) irradiating said object with light;(c) changing a relative position between said object and said structured optical pattern;(d) using said detector to detect one or more optical signals from said object through said structured optical pattern; and(e) obtaining time series signal information indicating temporal change in intensity of said one or more optical signals detected by said detector.14. The method of claim 13 , further comprising reconstructing said one or more time-independent images associated with said object from said time series signal information.15. The method of claim 13 , wherein said changing said relative position between said object and said structured optical pattern is provided by movement of said object.16. The method of claim 13 , wherein said changing said relative position between said object and said ...

OPTICAL DEVICE

An optical device, such as a microscope, is disclosed that can be assembled from flat materials. The optical device can be assembled via a series of folds of a flat material. The optical microscope can include a stage for supporting a sample, an optic stage, and a light source. The optic stage can include one or more lenses. The optical microscope can be capable of obtaining simultaneous images from different forms of microscopy. The optical microscope may have bright field and filter field viewing capabilities wherein a user shifts from bright field to filter field by lateral movement of the stage containing a lens and a light source that cooperate to provide either the bright field or the filter field. 1. An optical microscope , comprising:a first stage for supporting a sample;a second stage engaged with the first stage and movable relative to the first stage, the second stage including an optic, the optic having a distance of less than about 3 mm from the sample to the opposite side of the optic; andan illumination stage comprising a light source, the illumination stage engaged with the first stage and second stage, the illumination stage movable with the second stage, the light source positioned adjacent to the first stage to facilitate viewing the sample using the optic, wherein the optical microscope is manufactured from a flat material that includes the first stage and second stage.2. The optical microscope of claim 1 , wherein the second stage is movable laterally relative to the first stage such that the optic can be positioned over a desired location on the sample.3. The optical microscope of claim 1 , wherein the first stage is configured to receive a substrate containing the sample.4. The optical microscope of claim 1 , wherein the sample is supported directly on the first stage.5. The optical microscope of claim 1 , the first stage further comprising: a sample area comprising a reagent to react with the sample.6. The optical microscope of claim 1 , ...

METHOD AND APPARATUS FOR DISCRIMINATING BETWEEN BLOODSTAINS, AND COMPUTER PROGRAM FOR EXECUTING THE METHOD

Provided is a method of discriminating between bloodstains, the method including obtaining a captured image of an analysis target; analyzing the captured image and extracting a scattering image of a plurality of bloodstains in the analysis target; estimating a scattering angle of the scattering image; and determining the plurality of bloodstains to be an impact spatter bloodstain if the scattering angle is greater than a preset reference angle, and determining the plurality of bloodstains to be a cessation cast-off bloodstain if the scattering angle is less than the reference angle. 1. A method of discriminating between bloodstains , the method comprising:obtaining a captured image of an analysis target;analyzing the captured image and extracting a scattering image of a plurality of bloodstains in the analysis target;estimating a scattering angle of the scattering image; anddetermining the plurality of bloodstains to be an impact spatter bloodstain if the scattering angle is greater than a preset reference angle, and determining the plurality of bloodstains to be a cessation cast-off bloodstain if the scattering angle is less than the reference angle.2. The method of claim 1 , wherein the extracting of the scattering image comprises estimating a scattering direction by using widths and lengths of the plurality of bloodstains in the analysis target.3. The method of claim 2 , wherein the estimating of the scattering angle of the scattering image comprises:generating a first reference line and a second reference line in outer areas of the scattering image by using the scattering direction, the first reference line and the second reference line facing different directions; andestimating the scattering angle by measuring an angle between the first reference line and the second reference line.4. The method of claim 3 , wherein the estimating of the scattering angle of the scattering image further comprises:externally displaying the first reference line and the second ...

CONTRAST-AMPLIFYING CARRIERS USING A TWO-DIMENSIONAL MATERIAL

A contrast-amplifying carrier for observing a sample, includes a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating when it is illuminated at normal incidence at an illumination wavelength λ through the substrate and when the face of the coating opposite the substrate is in contact with a medium referred to as a transparent ambient medium, the refractive index nof which is lower than that of the refractive index no of the substrate. The absorbent coating comprises: an absorbent sublayer referred to as the contrast sublayer, deposited on the surface of the transparent substrate; and an absorbent layer referred to as the sensitive layer, distinct from the contrast sublayer and comprising between 1 and 5 sheets of a graphene-type material. Methods for producing and for using such a contrast-amplifying carrier are also provided. 1. A contrast-amplifying carrier for observing a sample , comprising a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating when it is illuminated at normal incidence at an illumination wavelength λ through said substrate and when the face of said coating opposite said substrate is in contact with a medium referred to as a transparent ambient medium , the refractive index nof which is lower than that of the refractive index no of said substrate , wherein said absorbent coating comprises:an absorbent sublayer that is absorbent at said illumination wavelength λ and which exhibits an antireflection behavior at this same wavelength, referred to as the contrast sublayer, deposited on the surface of said transparent substrate; andan absorbent layer referred to as the sensitive layer, distinct from said contrast sublayer and comprising between 1 and 5 sheets of at least one two-dimensional material.2. The contrast-amplifying carrier as claimed in claim 1 , wherein said contrast sublayer is chosen from:a layer of impurities implanted ...

Optical resonator, carbon isotope analysis device using same, and carbon isotope analysis method

A carbon isotope analysis method, including the steps of: generating carbon dioxide isotope from carbon isotope; feeding the carbon dioxide isotope into an optical resonator having a pair of mirrors; applying irradiation light having an absorption wavelength of the carbon dioxide isotope into the optical resonator; adjusting a relative positional relationship between the mirrors so that an optical axis of the irradiation light and an optical axis of light generated by the etalon effect are not matched; measuring the intensity of the transmitted light generated by resonance of carbon dioxide isotope excited by the irradiation light; and calculating the concentration of the carbon isotope from the intensity of the transmitted light. An optical resonator that can be suppressed in the parasitic etalon effect, and a carbon isotope analysis device and a carbon isotope analysis method, by use of the optical resonator, are provided.

AUTOMATED OPTICAL INSPECTION AND CLASSIFICATION APPARATUS BASED ON A DEEP LEARNING SYSTEM AND TRAINING APPARATUS THEREOF

The present invention provides an automated optical inspection and classification apparatus based on a deep learning system, comprising a camera and a processor. The processor executes a deep learning system after loading data from a storage unit and the processor, and comprises an input layer, a neural network layer group, and a fully connected-layer group. The neural network layer group is for extracting to an input image and thereby obtaining a plurality of image features. The fully connected-layer group is for performing weight-based classification and outputting an inspection result. 1. An automated optical inspection and classification apparatus based on a deep learning system , to be used to detect a defect of an object through an image of the object , the automated optical inspection and classification apparatus comprising: an input layer for receiving and normalizing the image of the object into an input image;', 'a neural network layer group for extracting the input image and thereby obtaining a plurality of image features, wherein the neural network layer group includes at least one neural network sub-block layer and a max-pooling layer; and', 'a fully connected-layer group with at least one fully connected layer for performing weight-based classification and outputting an inspection result;', an element-wise (eltwise) layer for performing a residual-related operation on an output of the first operational subset and an output of the second operational subset, and', 'a rectified linear unit (ReLU) for performing a nonlinear operation on an output of the eltwise layer., 'wherein the neural network sub-block layer includes: a first operational subset and a second operational subset that share a common input,'}], 'a processor for executing the deep learning system after loading data from a storage unit, wherein the deep learning system includes2. The automated optical inspection and classification apparatus of claim 1 , wherein the first operational subset ...

Real-time detection of particulate matter during deposition chamber manufacturing

Implementations disclosed describe a system that includes a deposition chamber, a light source to produce an incident beam of light, wherein the incident beam of light is to illuminate a region of the deposition chamber, and a camera to collect a scattered light originating from the illuminated region of the deposition chamber, wherein the scattered light is to be produced upon interaction of the first incident beam of light with particles inside the illuminated region of the deposition chamber. The described system may optionally have a processing device, coupled to the camera, to generate scattering data for a plurality of locations of the illuminated region, wherein the scattering data for each location comprises intensity of the scattered light originating from this location.

MICROFLUIDIC SYSTEM AND METHOD WITH FOCUSED ENERGY APPARATUS

A method of inseminating an animal including flowing a stream of a population of sperm cells through a channel, differentiating the sperm cells into two subpopulations of X-chromosome containing sperm cells and Y-chromosome containing sperm cells, selecting a desired subpopulation, ablating an undesired subpopulation, and collecting both the subpopulations of sperm cells including the desired subpopulation and the ablated undesired subpopulation together, wherein the collected population of sperm cells is used to fertilize an egg. 1. A method for producing a sexed composition of sperm comprising non-human animal sperm by identifying a subpopulation of sperm from a population of sperm in a sample fluid , the method comprising:staining the population of sperm in the sample fluid with a dye;defining a gating strategy for differentiating the subpopulation of sperm in the sample fluid in the population of sperm based on one or more physical characteristics of sperm in the population of sperm, wherein the one or more physical characteristics are identifiable within the population of sperm based in part on the dye staining, and wherein the gating strategy comprises identifying one or more desired physical characteristics of the subpopulation of sperm;measuring the one or more physical characteristics for the sperm in the population of sperm;identifying sperm in the subpopulation of sperm based on the measured one or more physical characteristics and the defined gating strategy; andgenerating the sexed composition of sperm comprising the subpopulation of sperm identified based on the measured one or more physical characteristics and the defined gating strategy.2. The method of claim 1 , wherein the population of sperm in the sample fluid comprises bovine sperm.3. The method of claim 1 , wherein the sexed composition of sperm substantially comprises X chromosome-bearing sperm cells.4. The method of claim 1 , wherein the sexed composition of sperm substantially comprises Y ...

INTERCHANGEABLE, VISUALLY MARKED SAMPLE INTRODUCTION SYSTEM MOUNTING STRUCTURE AND COMPONENTS FOR INDUCTIVELY COUPLED PLASMA SYSTEMS

A system can include an exchangeable mounting structure having a visual marking or coloring and at least one physically associated sample introduction system component having an indicating mark or color matching the visual marking or coloring of the exchangeable mounting structure. The visual marking or colored corresponds to a sample analysis configuration for analyzing a particular sample type at an analytical instrument. 1. A system comprising:an exchangeable mounting structure having at least one of a visual marking or a coloring, the exchangeable mounting structure configured to couple with an inductively coupled plasma analytical instrument; anda physically associated sample introduction system component having at least one of a visual mark or a coloring matching the at least one of a visual marking or a coloring of the exchangeable mounting structure, wherein the at least one of a visual marking or a coloring corresponds to a sample analysis configuration for analyzing a particular sample type at the inductively coupled plasma analytical instrument.2. The system of claim 1 , further comprising:a second sample introduction system component having at least one of a visual mark or a coloring that differs the at least one of a visual mark or a coloring of the physically associated sample introduction system component, the at least one of a visual mark or a coloring of the second sample introduction system component corresponding to a second sample analysis configuration for analyzing a second sample type at the inductively coupled plasma analytical instrument.3. The system of claim 1 , further comprising:a second sample introduction system component having at least one of a visual mark or a coloring that matches the at least one of a visual marking or a coloring of the exchangeable mounting structure.4. The system of claim 1 , wherein the physically associated sample introduction system component includes a first visual mark or coloring and a second visual mark ...

SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING BODY-CONFORMING ANIMAL BED, CALIBRATION CELL AND ORGAN PROBABILITY MAP FOR QUANTITATIVE OPTICAL IMAGING OF ANATOMICAL STRUCTURES

Exemplary systems, methods and computer accessible mediums which can determine quantitative information of a tissue(s) can be provided, which can include receiving optical information regarding the tissue(s), and determining the quantitative information of the tissue(s), in real time and during the receipt of the optical information, using an atlas. The tissue(s) can be part of a mouse, and the quantitative information can be an in-vivo count of cells or bacteria in the tissue(s). The quantitative information can be determined by co-registering the in-vivo count to the atlas. The optical information can be generated using a mirror gantry(s) so as to simultaneously image at least two opposing views of the tissue(s). 1. A non-transitory computer-accessible medium having stored thereon computer-executable instructions for determining quantitative information of at least one tissue , wherein , when a computer hardware arrangement executes the instructions , the computer arrangement is configured to perform procedures comprising:receiving optical information regarding the at least one tissue; anddetermining the quantitative information of the at least one tissue, in real time and during the receipt of the optical information, using at least one atlas.2. The computer-accessible medium of claim 1 , wherein the at least one tissue is part of a mouse.3. The computer-accessible medium of claim 1 , wherein the quantitative information is an in-vivo count of at least one of cells or bacteria in the at least one tissue.4. The computer-accessible medium of claim 3 , wherein the in-vivo count of the bacteria is a lux-bacteria count.5. The computer-accessible medium of claim 4 , wherein the computer arrangement is further configured to determine the lux-bacteria count using bioluminescence tomography.6. The computer-accessible medium of claim 5 , wherein the computer arrangement is further configured to determine the lux-bacteria count based on a calibration protocol.7. The ...

VOID-ARRANGED STRUCTURE AND MEASUREMENT METHOD USING THE SAME

A void-arranged structure that includes a pair of principal surfaces opposing each other and a plurality of void sections that penetrate through the pair of principal surfaces. The void-arranged structure is configured of a plurality of unit structures each of which includes a first void section and a second void section having a different shape from a shape of the first void section, and the overall shape of the unit structure, when the principal surface is viewed from above, is not mirror-symmetric with respect to a predetermined imaginary plane orthogonal to the principal surface of the void-arranged structure. 1. A void-arranged structure comprising:a pair of principal surfaces opposing each other; anda plurality of unit structures each of which has a same shape and includes at least two void sections aligned at a predetermined interval, which are connected two-dimensionally and periodically along a direction of a first principal surface of the pair of principal surfaces, and wherein the void sections penetrate through the pair of principal surfaces, whereineach unit structure of the plurality of unit structures includes a first void section and a second void section having a different shape from a shape of the first void section, andan overall shape of each unit structure, when viewed from the first principal surface, is not mirror-symmetric with respect to a predetermined imaginary plane orthogonal to the first principal surface of the void-arranged structure.2. The void-arranged structure according to claim 1 , wherein the imaginary plane is a plane perpendicular to a polarizing direction of electromagnetic waves irradiated on the void-arranged structure.3. The void-arranged structure according to claim 2 , wherein a shape of the first void section is not mirror-symmetric with respect to the imaginary plane.4. The void-arranged structure according to claim 1 , wherein a shape of the first void section is not mirror-symmetric with respect to the imaginary ...

Method for regulating the relative position of an analyte in relation to a light beam

A method for regulating the relative position of an analyte of a sample ( 16 ) in relation to a light beam (F) includes the illumination of the analyte of the sample ( 16 ) with the light beam (F), capturing by an imaging device ( 38 ) a transmission image of the beams scattered by the analyte of the sample ( 16 ) in order to establish a diffraction pattern, and modifying the relative position of the analyte of the sample ( 16 ) in relation to the light beam (F) according to at least one property of the diffraction pattern.

FIBRE OPTIC MONITORING INSTALLATION AND METHOD

The invention relates to installations for fibre optic monitoring of articles, and apparatus and methods for forming such installations, including a modular system and components for forming a fibre optic monitoring installation. Applications of the invention include the monitoring of vessels, chambers, and fluid conduits in industrial processing plants, and the invention has particular application to monitoring large vessels, for example temperature monitoring of vessels used in catalytic reforming processes. Convenient installation on or removal from the article being monitored is achieved by providing a support structure for the fibre optic length, which presents the fibre optic length in a preconfigured orientation suitable for monitoring the article. In a particular embodiment of the invention, the fibre optic length is disposed on a panel in a plurality of dense spiral patterns. 166.-. (canceled)67. A fibre optic monitoring installation comprising:an article having an outer surface to be monitored;a fibre optic support structure arranged to support a fibre optic length, wherein the support structure comprises a frame defining a monitoring area which corresponds to a part of the outer surface of the article, and the fibre optic length is arranged in a predetermined pattern or orientation on a first surface of the frame such that the fibre optic length is located over the monitoring area defined by the frame;means for locating the fibre optic support structure in relation to the article such that, in use, the fibre optic length is sensitive to a condition of the outer surface of the article; andfibre optic instrumentation coupled to the fibre optic length,wherein the support structure is configured to be located in relation to the article to form an in situ support for subsequent installation of the fibre optic length onto the support structure.68. The fibre optic monitoring installation according to claim 67 , wherein the means for locating the fibre optic ...

DAMAGE DETECTION APPARATUS FOR LOCK GATE SILL

The present invention discloses a damage detection apparatus for a lock gate sill, including a support, a water storage tank, a water inlet barrel, a filter device, a water pump, and a control device, wherein a barrier is vertically disposed at the bottom of the water storage tank, multiple water discharge pipes are vertically disposed in the barrier, upper ends of the water discharge pipes are communicated with the water storage tank, the water discharge pipes have different heights, lower ports of the water discharge pipes together compose a truncated conical cavity, a camera is disposed at the bottom of the water storage tank in a sealed manner, and a lens of the camera is located in an upper part of the truncated conical cavity. When it is desired to perform damage detection for the lock gate sill, muddy water is filtered by the filter device into clear water, and the clear water is pressurized by the water pump and then discharged from the water discharge pipes, such that the muddy water in the barrier is continuously diluted by clear water, the camera is in a shooting environment of clear water, and the lock gate sill is shot for detection at this time, whereby it is ensured that the taken picture has good definition, and thus the position of abrasion and the amount of abrasion of the lock gate sill can be clearly determined. 1. A damage detection apparatus for a lock gate sill , comprising:a) a support, wherein rollers enabling the damage detection apparatus for the lock gate sill to move are disposed at a lower part of the support, and wherein motors driving the rollers to rotate are disposed on the support;b) a water storage tank disposed on the support, wherein a barrier is vertically disposed at the bottom of the water storage tank, wherein an upper end of the barrier is hermetically connected to the bottom of the water storage tank, wherein a lower end of the barrier has an opening structure, wherein multiple water discharge pipes are vertically disposed ...

DETECTION SYSTEMS AND METHOD FOR MULTI-CHEMICAL SUBSTANCE DETECTION USING ULTRAVIOLET FLUORESCENCE, SPECULAR REFLECTANCE, AND ARTIFICIAL INTELLIGENCE

Embodiments of this invention relate generally to detection systems and a method for chemical substance detection using UV fluorescence, specular reflectance, and artificial intelligence. In one example, a handheld detection system comprises single or multiple excitation light sources at discrete wavelengths operating in an ultraviolet portion of an electromagnetic spectrum. The single or multiple excitation light sources are operated intermittently, either all in concert or individually, at a frequency of about 100 Hz to 1000 Hz. Multiple detectors are configured as channels to operate at discrete wavelengths to detect a multiplicity of emissions produced by the excitation energy. A multi-channel electronic or software-implemented detector is synchronized in both phase and frequency with the excitation light sources so that a signal of interest is detected in the multiplicity of emissions.

Method and Device for Express Analysis of Acetone Traces in Gases

A device apparatus for measuring acetone levels exhaled air in order to determine the content of glucose in the blood is provided. The device includes a chemical sensor cell having a vertically oriented hollow truncated cone with one end having a first diameter and an opposite end having a second diameter that is larger than the first diameter and also a solution housed within the chemical sensor cell. 1. A device for measuring the concentration of acetone in exhaled air in order to determine the content of glucose in the blood , comprising:a chemical sensor cell comprising a vertically oriented hollow truncated cone with one end having a first diameter and an opposite end having a second diameter that is larger than the first diameter; and,a solution housed within the chemical sensor cell.2. The device of claim 1 , wherein the chemical sensor cell further comprises an outlet positioned proximal to the one end of the chemical sensor cell having the first diameter and an inlet positioned proximal to the opposite end of the chemical sensor cell having the second diameter.3. The device of claim 1 , wherein the chemical sensor cell is made of transparent plastic.4. The device of claim 2 , wherein the outlet of the chemical sensor cell is coupled to a valve.5. The device of claim 1 , wherein the solution contains a solute selected from the group consisting of Sodium Iodate claim 1 , Sodium Nitroprusside claim 1 , Metadiamine claim 1 , Phenyl-hydrazone claim 1 , Furfural claim 1 , o-Nitrobenzaldehyde claim 1 , and combinations thereof.6. The device of claim 2 , further comprising:a dosator coupled to the inlet of the chemical sensor cell;a light emitter coupled to the chemical sensor cell;an optical sensor coupled to the chemical sensor cell; and,a microprocessor coupled to the optical sensor.7. The device of claim 6 , wherein the dosator is coupled to an actuator.8. The device of claim 7 , wherein the actuator is coupled to a valve.9. The device of claim 6 , further ...

INSTANTANEOUS MULTI-WAVELENGTH FLUORESCENCE DETECTION INSTRUMENT AND DETECTION METHOD THEREOF

The present invention discloses an instantaneous multi-wavelength fluorescence detection instrument and an instantaneous multi-wavelength fluorescence detection method, relating to the field of medical instruments. The instantaneous multi-wavelength fluorescence detection instrument includes a card holder having an accommodating groove, a driving mechanism configured to drive the card holder to move, and an optical module for fluorescence detection. An optical module generates irradiation light of different wavelength by a light source. The irradiation light irradiates the sample to be detected through the first dichroic mirror to generate fluorescence signals of different wavelengths. The fluorescence signals form multiple fluorescence transmission paths through second dichroic mirrors, some of the fluorescence transmission paths are at a reflection light path of the second dichroic mirrors and some of the fluorescence transmission paths are at a transmission light path of the second dichroic mirrors. The fluorescence of different wavelengths is received by a corresponding optical element. 1. An instantaneous multi-wavelength fluorescence detection instrument , comprising:{'b': '20', 'a card holder () having an accommodating groove;'}{'b': 17', '20, 'a driving mechanism () configured to drive the card holder () to move; and'}{'b': 60', '60', '601', '602', '603, 'an optical module () for fluorescence detection, the optical module () comprising an excitation light source component () having at least one excitation light channel, a color filter component () configured to form multiple fluorescence transmission paths and a fluorescence receiving component () having multiple fluorescence receiving channels, wherein the excitation light source'}{'b': 601', '81', '71', '81', '71', '20', '81', '17', '602', '81', '602', '82', '603', '93', '82, 'component () comprises a first dichroic mirror () and a light source () configured to generate irradiation light, the first ...

RECONFIGURABLE INTEGRATED CIRCUITS FOR ADJUSTING CELL SORTING CLASSIFICATION

Aspects of the present disclosure include reconfigurable integrated circuits for characterizing particles of a sample in a flow stream. Reconfigurable integrated circuits according to certain embodiments are programmed to calculate parameters of a particle in a flow stream from detected light; compare the calculated parameters of the particle with parameters of one or more particle classifications; classify the particle based on the comparison between the parameters of the particle classifications and the calculated parameters of the particle; and adjust one or more parameters of the particle classifications based on the calculated parameters of the particle. Methods for characterizing particles in a flow stream with the subject integrated circuits are also described. Systems and integrated circuit devices programmed for practicing the subject methods, such as on a flow cytometer, are also provided. 1. A reconfigurable integrated circuit programmed to:calculate parameters of a particle in a flow stream from detected light;compare the calculated parameters of the particle with parameters of one or more particle classifications;classify the particle based on the comparison between the parameters of the particle classifications and the calculated parameters of the particle; andadjust one or more parameters of the particle classifications based on the calculated parameters of the particle.2. The reconfigurable integrated circuit according to claim 1 , wherein the particle classifications comprise a sort classification.3. The reconfigurable integrated circuit according to any one of - claim 1 , wherein classifying the particle comprises generating a particle sort decision.4. The reconfigurable integrated circuit according to claim 3 , wherein the integrated circuit is programmed to generate the particle sorting decision based on a threshold between the calculated parameters of the particle and the parameters of the particle classifications.5. The reconfigurable ...

Luminescence Reference Standards

The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis. 1. A luminescence reference device comprising:a sample-support device, wherein the sample-support device is comprised of a plurality of fluid compartments; andat least one emissive element distributed in the plurality of fluid compartments of the sample-support device, wherein the at least one emissive element comprises at least one nanocrystalline material.2. The luminescence reference device of claim 1 , wherein the sample-support device is a microtiter plate.3. The luminescence reference device of claim 1 , wherein the sample-support device is a cell culture plate.4. The luminescence reference device of claim 1 , wherein the at least one nanocrystalline material has an emission peak in the range between ultraviolet to near-infrared.5. The luminescence reference device of claim 1 , wherein the at least one nanocrystalline material has an emission peak in the range between 500 nm to 700 nm. This application is a divisional of patent application Ser. No. 12/338,778 filed Dec. 18, 2008; which is a continuation of patent application Ser. No. 11/173,609 filed Jun. 30, 2005, now U.S. Pat. No. 7,480,042; which claims a priority benefit under 35 U.S.C. §119(e) from U.S. Patent Application No. 60/584,890 filed Jun. 30, 2004; all of which are incorporated herein by reference.The identity, properties, and interactions of samples such as biomolecules can be analyzed by detecting light emitted by or otherwise originating from the sample. The emitted light can arise naturally in the sample and/or be induced by illumination or other stimulus. In either case, the emitted light can be detected, and the illumination optionally can be provided, by a ...

POWER SUPPLY CONTROL METHOD AND APPARATUS OF BATTERY MANAGEMENT SYSTEM

Disclosed is a battery management system (BMS) power supply management apparatus and method. The BMS power supply management apparatus includes an optoelectronic element configured to generate a current in response to an optical signal, a conversion element configured to convert the current into a wake-up voltage, and a first switch configured to switch a wake-up signal for a BMS, in response to the wake-up voltage. 1. A battery management system (BMS) power supply management apparatus , comprising:an optoelectronic element configured to generate a current in response to an optical signal;a conversion element configured to convert the current into a wake-up voltage; anda first switch configured to switch a wake-up signal for a BMS, in response to the wake-up voltage.2. The BMS power supply management apparatus of claim 1 , further comprising:a second switch configured to switch a current flowing through the first switch.3. The BMS power supply management apparatus of claim 1 , further comprising:a first resistor connected the optoelectronic element and a battery.4. The BMS power supply management apparatus of claim 3 , further comprising:a second resistor connected to the conversion element and a battery such that the wake-up voltage is applied thereto.5. The BMS power supply management apparatus of claim 1 , further comprising:a controller configured to control the first switch based on the wake-up signal.6. The BMS power supply management apparatus of claim 5 , wherein the controller is configured to supply power to the BMS by shorting the first switch based on the wake-up signal.7. The BMS power supply management apparatus of claim 5 , further comprising:a first control switch configured to control the first switch, in response to a control of the controller.8. The BMS power supply management apparatus of claim 2 , further comprising:a second control switch configured to control the second switch, in response to a control of the controller.9. The BMS power supply ...

INSPECTION SYSTEM FOR MANUFACTURED COMPONENTS

An inspection system includes a base, an array of fixtures, and a plurality of sensors or light sources. Each fixture has a first portion rotatably secured to the base and configured to rotate about a yaw axis and a second portion rotatably secured to the first portion and configured to rotate about a pitch axis. Each sensor or light source is secured to one of the fixtures and is configured to direct light at yaw and pitch angles relative to the base. 1. An inspection system for manufactured components comprising:a base;an array of fixtures arranged radially about a center of the base, each fixture having (i) a first portion rotatably secured to the base and configured to rotate about a yaw axis and (ii) a second portion rotatably secured to the first portion and configured to rotate about a pitch axis;a plurality of light sources, each light source secured to one of the fixtures in the array of fixtures and configured to direct light (i) at a yaw angle about the yaw axis of the respective fixture relative to the center of the base, (ii) away from the base at a pitch angle about the pitch axis of the respective fixture relative to the base, and (iii) toward the manufactured components; and rotate the first portions of each fixture about each respective yaw axis to adjust the yaw angle at which each light source directs light relative to the center of the base and toward the manufactured components, and', 'rotate the second portions of each fixture about each respective pitch axis to adjust the pitch angle at which each light source directs light away from the base and toward the manufactured components., 'a controller programmed to, in response to a command to inspect the manufactured components,'}2. The inspection system of claim 1 , wherein the first portion of each fixture includes a protrusion that extends outward from the base.3. The inspection system of further comprising an outer ring that is disposed about the base claim 2 , the outer ring having outwardly ...

INSPECTION WINDOW

An apparatus comprises an optical pane transparent to infrared radiation. The pane includes first and second sides, a periphery, and a retention region. A frame defines an opening that can accept the pane and includes a pane retention region. Additionally, a retainer is configured to secure the optical pane in the opening and includes a retaining surface mated to the pane support surface of the frame and configured to support the optical pane at the retention region. The pane, frame and retainer are configured to have mating features which can include a bead, a retaining ridge, a labyrinth configuration and protrusions, recesses, channels, or steps or a combination of these features.

GRAIN TRANSILLUMINATING DEVICE

An object of the present invention is to provide a grain transilluminating device capable of detecting all of the cracks whose orientations are variously different depending on grains without causing a sample dish to be rotated. According to the present invention, there is provided a grain transilluminating device causing light to enter a transparent bottom face of a sample dish obliquely from a downside, the device including: a base member; a rotary member rotatably disposed in the base member and having a light source on one lateral side, and provided with a reflective plate reflecting the light from the light source toward the bottom face of the sample dish; and a cover member attached onto the base member to constitute, along with the base member, an outer frame and having an opening part positioned above the rotary member to receive the sample dish, wherein an operating part for rotating operation on the rotary member is provided in the rotary member and an opening is formed in the outer frame, and the operating part is configured to extend outside from the outer frame through the opening and to be swingable with a center of the rotary member being an axis. 1. A grain transilluminating device causing light to enter a transparent bottom face of a sample dish obliquely from a downside , the device comprising:a base member;a rotary member rotatably disposed in the base member and having a light source on one lateral side; anda cover member attached onto the base member to constitute, along with the base member, an outer frame and having an opening part positioned above the rotary member to receive the sample dish, whereinan operating part for rotating operation on the rotary member is provided in the rotary member and an opening is formed in the outer frame, andthe operating part is configured to extend outside from the outer frame through the opening and to be swingable with a center of the rotary member being an axis.2. The grain transilluminating device ...

TARGET SUBSTANCE DETECTION DEVICE AND TARGET SUBSTANCE DETECTION METHOD

To detect a target substance accurately and effectively, a target substance detection device includes: a liquid-sample introducing plate formed from a light-transmissive plate having a surface on which a liquid sample including a target substance and magnetic particles forming a conjugate with the target substance is introduced, and enabling propagating transmitted light of light irradiated from the rear face upward of the surface as propagated light; a rear face light irradiation unit configured to be able to irradiate the liquid-sample introducing plate with light from the rear face; a first magnetic field application unit disposed on the side of the surface of the liquid-sample introducing plate , and configured to apply a magnetic field to move the conjugate in the liquid sample that is introduced on the surface of the liquid-sample introducing plate in the direction away from the liquid-sample introducing plate ; and an optical-signal detection unit disposed on the side of the surface of the liquid-sample introducing plate , and enabling detection of a change in optical signal based on the propagated light between before and after application of the magnetic field by the first magnetic field application unit 1. A target substance detection device comprising:a liquid-sample holding unit including a liquid-sample introducing plate introducing any one of: a light-transmissive plate having a surface on which a liquid sample including a target substance and magnetic particles forming a conjugate with the target substance is introduced, and capable of propagating transmitted light of light irradiated from a rear face or the surface to the face on an opposite of the irradiated face as propagated light; a reflective plate having a surface on which the liquid sample is introduced and capable of propagating reflected light of light irradiated from the surface upward of the surface as propagated light; and an introducing plate having a surface on which the liquid sample ...

SENSOR

A purpose of the present invention is to provide a sensor with high sensitivity or high target substance selectivity. 1. A sensor comprising:a structure having an internal space into which a detection target is capable of flowing;a light-emitting element; anda photo-receptor element,wherein the sensor is disposed so that light emitted from the light-emitting element passes through the internal space to reach the photo-receptor element, anda wavelength of light emitted from the light-emitting element falls within a range from 2.5 μm to 15 μm inclusive.2. The sensor according to claim 1 , wherein a length of the internal space in a direction perpendicular to an extension direction of the structure is less than or equal to 1000 μm.3. The sensor according to claim 1 , wherein claim 1 , in the internal space claim 1 , an optical path length of the light is less than or equal to 1000 μm.4. The sensor according to claim 1 , wherein the structure includes a first substrate and a second substrate claim 1 , the first substrate and the second substrate bonding at respective peripheral portions of the internal space.5. (canceled)6. (canceled)7. The sensor according to claim 1 , wherein the structure includes a first end in an extension direction of the internal space claim 1 , and a second end on an opposite side of the structure from the first end claim 1 , the first end being closed claim 1 , the second end being open so that the detection target is capable of entering and exiting.8. The sensor according to claim 7 , wherein the second end includes an inflow port and an outflow port for the detection target.9. The sensor according to claim 7 , wherein a distance from the light-emitting element to the first end in the structure is shorter than a distance from the light-emitting element to the second end in the structure.10. The sensor according to claim 1 , further comprising a printed substrate claim 1 ,wherein the light-emitting element, the photo-receptor element, and the ...

APPARATUSES AND METHODS FOR SUSPENDING AND WASHING THE CONTENTS OF A PLURALITY OF CUVETTES

Apparatuses and methods for washing a plurality of fluid samples are disclosed herein. In an embodiment, a system for washing a plurality of fluid samples respectively located within a plurality of cuvettes includes a rotor configured to rotate the plurality of cuvettes about an axis, a traveler mechanism located beneath the rotor, the traveler mechanism configured to move a plurality of magnets parallel to the axis of rotation of the rotor to position the plurality of magnets so that each cuvette of the plurality of cuvettes is located adjacent to at least one magnet of the plurality of magnets, and a wash system located above the rotor, the wash system configured to at least one of inject fluid into or aspirate fluid from the plurality of the cuvettes, while the plurality of magnets suspend magnetic particles located within each of the plurality of cuvettes. 1. A system for washing a plurality of fluid samples respectively located within a plurality of cuvettes , comprising:a rotor configured to rotate the plurality of cuvettes about an axis;a traveler mechanism located beneath the rotor, the traveler mechanism configured to move a plurality of magnets parallel to the axis of rotation of the rotor to position the plurality of magnets so that each cuvette of the plurality of cuvettes is located adjacent to at least one magnet of the plurality of magnets; anda wash system located above the rotor, the wash system configured to at least one of inject fluid into or aspirate fluid from the plurality of the cuvettes, while the plurality of magnets suspend magnetic particles located within each of the plurality of cuvettes.2. The system of claim 1 , wherein the axis of rotation of the rotor is a vertical axis.3. The system of claim 1 , wherein the wash system is configured to inject fluid into and aspirate fluid from the plurality of the cuvettes.4. The system of claim 1 , wherein the plurality of magnets includes a plurality of first magnets with a first polarity and a ...

COMPLEMENTARY SAFETY SYSTEMS FOR LASER INDUCED BREAKDOWN SPECTROSCOPY

In the operation of analytical devices, and particularly laser induced breakdown spectroscopy (LIBS) devices, a number of advantages may be obtained by the use of complementary safety mechanisms, such as those that govern the operation or firing of a laser. Such complementary safety mechanisms, compared to the individual safety mechanisms acting alone, prevent operation of the laser under a greater number of unsafe circumstances (even if one or more detected conditions are safe, based on not activating the associated safety mechanism) and permits operation under a greater number of safe circumstances (even if one or more detected conditions are unsafe, based on activating the associated safety mechanism). 1. A laser induced breakdown spectroscopy (LIBS) device , comprising:a laser configured to direct a laser beam through a sample chamber to a surface of a sample, anda spectrometer configured to determine a spectral distribution of emissions from the sample in response to the laser beam;the device further comprising two or more complementary safety mechanisms, selected from the group consisting of:a chamber pressure based safety mechanism that receives a detected parameter within the sample chamber;a chamber light based safety mechanism that receives a detected parameter within the sample chamber;a conductive sample based safety mechanism that receives a detected parameter of the sample; anda spectral-feedback based safety mechanism that receives the spectral distribution from the spectrometer.2. The device of claim 1 , wherein the chamber pressure based safety mechanism is activated when the detected parameter within the sample chamber is a measured pressure that is below a threshold pressure.3. The device of claim 2 , wherein the threshold pressure is relative to ambient pressure.4. The device of claim 1 , wherein chamber light based safety mechanism is activated when the detected parameter within the sample chamber is a measured light intensity that exceeds a ...

OPTICAL SENSOR

An optical sensor for the ascertainment within a medium of a measured value of a measured parameter of process automation technology, comprising: a light source for transmitting transmission light; a prism; and a receiver for receiving reception light and generating a reception signal therefrom, wherein the measured value is ascertainable from the reception signal, wherein a first optical path from the light source to the medium is defined at least via the prism, wherein a second optical path from the medium to the receiver is defined at least via the prism, wherein the transmission light passes through the prism and is transformed within the medium into reception light, which passes through the prism to the receiver, and wherein the first optical path and the second optical path are essentially parallel to each other. 1. An optical sensor for determining a measured value within a medium of a measured parameter of process automation technology , comprising:a light source adapted to generate transmission light;a prism, wherein the transmission light passes through the prism into the medium, within which the transmission light is transformed into reception light; anda receiver adapted to receive the reception light from the medium via the prism and to generate a reception signal from the reception light, wherein the measured value is determined from the reception signal,wherein a first optical path is defined from the light source to the prism, and a second optical path is defined from the prism to the receiver, andwherein the first optical path and the second optical path are substantially parallel to each other on a side of the prism opposite the medium.2. The sensor of claim 1 , further comprising a housing including a window that is at least translucent with respect to transmission light and the reception light claim 1 , wherein the prism and window are separated claim 1 , cemented claim 1 , bonded claim 1 , merged or a single claim 1 , integral piece.3. The ...

DEVICE AND SYSTEM FOR COLLECTING AND ANALYZING VAPOR CONDENSATE, PARTICULARLY EXHALED BREATH CONDENSATE, AS WELL AS METHOD OF USING THE SAME

The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile-phone, and performing such collection and analysis by a person without any professionals. 1. A device for collecting and analyzing a vapor condensate (VC) sample , comprising: i. the plates are movable relative to each other into different configurations;', 'ii. one or both plates are flexible;', 'iii. each of the plates has, on its respective surface, a sample contact area for contacting a vapor condensate (VC) sample that contains an analyte;', 'iv. one or both of the plates comprise spacers, wherein at least one of the spacers is inside the sample contact area;, 'a collection plate and a cover plate, whereinwherein one of the configurations is an open configuration, in which: the two plates are either completely or partially separated apart, the spacing between the plates is not regulated by the spacers, and the VC sample is deposited on one or both of the plates by directly condensing a vapor on the plate or the plates; andwherein another of the configurations is a closed configuration which is configured after the VC sample deposition in the open configuration; and in the closed configuration: at least a part of the VC sample is between the two plates and in contact with the two plates, and has a highly uniform thickness that is regulated by the spacers and the two sample surfaces of the plates and is equal to or less than 30 um with a small variation.2. The device of claim 1 , wherein the device further comprises a dry reagent coated on one or both of the plates.3. The device of claim 1 , wherein the ...

HIGHLY COMPACT MULTI-OPTICAL-JUNCTION OPTICAL FLOWCELL AND FLEXIBLY DEPLOYABLE OPTICAL SENSING ASSEMBLIES AND SYSTEMS FOR IN-SITU REAL-TIME SPECTROSCOPIC MEASUREMENTS

A highly compact multi-optical-junction optical flowcell includes a housing having an internal channel, to which a plurality of source optical signal modules can be coupled, e.g., in a peripheral manner. The source optical signal modules can include a set of LEDs and/or semiconductor lasers, and can be coupled to the flowcell by way of a standard optical coupling such as an SMA-type optical connector. An excitation detection apparatus or subsystem can also be coupled to the flowcell to facilitate multiple types of optical measurements, including fluorescence spectroscopy, absorption spectroscopy, and turbidity measurements. A sensing apparatus or system that includes a multi-optical-junction optical flowcell, a plurality of source optical signal modules, and an excitation detection apparatus can be carried by or deployed on a wide variety of platforms, such as Autonomous Underwater Vehicles (AUVs), Autonomous Surface Vehicles (ASVs), buoys, or other platforms, in a space efficient and power efficient manner. 1. An optical flowcell assembly comprising:a housing having an axial extent, a transverse extent, a periphery, and an internal channel having a length extending along a portion of the housing's axial extent, parallel to an optical signal detection axis of the flowcell assembly;at least one fluid inlet configured for fluid communication with the internal channel;at least one fluid outlet configured for fluid communication with the internal channel;a plurality of transverse optical junctions configured for directing optical signals into the internal channel along an optical signal propagation path that is offset from the flowcell assembly's optical signal detection axis; andat least one axial optical junction configured for receiving optical signals propagating from the internal channel to the at least one axial optical junction.2. The optical flowcell assembly of claim 1 , wherein the plurality of transverse optical junctions is configured for directing optical ...

Spectral imaging apparatus and methods

An imaging system images a sample across one or more wavelengths. A light source illuminates a sample with one or more wave-lengths of light, and an image sensor detects light from the illuminated sample. A linear variable long pass filter is positioned to filter light reflected from the sample to pass to the image sensor multiple different wave-length bands having different cut-off wavelengths. Wavelengths of light on one side of the cut-off wavelength are blocked and wavelengths of light on the other side of the cut-off wavelength are passed as multiple different long pass wavelength bands for detection by the image sensor. The image sensor detects light for each of the multiple different long pass wavelength bands from the sample. Data processing circuitry converts the detected light for the multiple different long pass wavelength bands for the sample into corresponding different long pass wavelength band data sets for the sample.

Method for producing a sensor cap with a membrane

The present disclosure relates to a method for manufacturing a sensor cap with at least one main body and a membrane for an optochemical or electrochemical sensor for determining and/or monitoring the concentration of an analyte in a measuring medium, a corresponding sensor cap, and a corresponding sensor. In one aspect of the present disclosure, a permeable membrane is provided with a surface for contacting the measuring medium, as well as a main body with at least one sector for connecting to the membrane. At least part of the membrane and main body are welded, wherein the membrane is at least partially applied to the at least one sector of the main body and a connection between the main body and membrane is sealed against the measuring medium.

Systems and methods for bio-inactivation

A system for irradiating a microplate may include a modular light engine with one or more light emitting devices. The light emitting devices are configured to emit germicidal radiation to irradiate the microplate, which is configured to be positioned below the modular light engine inside a chamber of the microplate irradiation system. In this way, a uniform intensity of germicidal radiation may be output by light emitting devices, resulting in disruption of contaminating nucleic acids present in the microplate.

Multi-cavity semi-open resonant photoacoustic cell and multi-gas simultaneous measurement system

The present invention belongs to the technical field of trace gas detection, and relates to a multi-cavity semi-open resonant photoacoustic cell and a multi-gas simultaneous measurement system. The photoacoustic cell includes multiple resonant cavities. Each resonant cavity has a unique length and a unique resonant frequency, so each resonant cavity corresponds to one to-be-measured gas. A sensitive diaphragm of an acoustic sensor is fixed on one end face of the photoacoustic cell. Photoacoustic signals of different frequencies generated in the resonant cavities act on the sensitive diaphragm of the acoustic sensor, causing the sensitive diaphragm of the acoustic sensor to vibrate periodically. Concentration information of multiple to-be-measured gases can be obtained by analyzing the vibration of the sensitive diaphragm of the acoustic sensor.

SPECTROMETER WITH WIDE-SCAN TUNABLE DIODE LASER

A method for implementation by a laser spectrometer is provided. The method includes first scanning, by a control unit using a first set of laser spectrometer operating parameters, a first wavelength range by adjusting a wavelength of light of a beam emitted by a laser light source and passing through a sample gas. The first wavelength range encompasses a first spectral feature corresponding to a first constituent. The method also includes at least one second scanning, by the control unit using a second set of laser spectrometer operating parameters, a second wavelength range by adjusting the wavelength of light emitted from the laser light source and passing through the sample gas. The second wavelength range has a second spectral feature corresponding to at least one second constituent. The control unit also determines a first concentration of the first constituent and a second concentration of the at least one second constituent. 1. A method for implementation by a spectrometer comprising a laser light source , a control unit , and at least one detector positioned such that light emitted by the laser light source is detected by the at least one detector after passing through a sample gas , the method comprising:first scanning, by the control unit using a first set of laser spectrometer operating parameters, a first wavelength range by adjusting a wavelength of light of a beam emitted by the laser light source and passing through the sample gas, the first wavelength range encompassing a first spectral feature corresponding to a first constituent;at least one second scanning, upon completion of the first scanning and by the control unit using a second set of laser spectrometer operating parameters at least partially different from the first set of laser spectrometer operating parameters, a second wavelength range by adjusting the wavelength of light emitted from the laser light source and passing through the sample gas, the second wavelength range having a second ...

Infusion Set And Adapter For Spectroscopic Analysis Of Pharmaceuticals

An infusion set and an intravenous bag adapter constructed of ultraviolet transmissive thermoplastic is used in spectroscopic validation of pharmaceuticals. The described hardware allows for qualitative and quantitative assurance of medications and is used to prevent medication errors. The thermoplastic is transmissive in the range of 240 to 315 nanometers. 1. An adapter for use in spectroscopically testing the contents of an IV bag , comprising:a tube with a first end engageable with the IV bag and a second, distal end;a chamber disposed between the first and second tube ends for holding a test sample of the contents of the IV bag; and,wherein the chamber comprises a translucent material that is transmissive of ultraviolet light.2. The invention of claim 1 , wherein the chamber is substantially transmissive of ultraviolet light having a wavelength of about 260-315 nanometers.3. The invention of claim 2 , wherein the chamber is comprised of a thermoplastic.4. The invention of claim 3 , wherein the thermoplastic is a polycyclic polyolefin.5. The invention of claim 1 , further comprising an incompletely shielded spectrometer with a receptacle for receiving the adapter claim 1 , sensors for sensing light in the range of 240 to 315 nanometers claim 1 , and means for programming the spectrometer with plots of medication concentration versus light absorption for specific medications claim 1 , wherein such light absorption is in the range of 240 to 315 nanometers. This invention relates to the spectroscopic analysis of chemical compounds. More specifically, the invention relates to an adapter and an infusion set for use in verifying pharmaceuticals as a means to prevent medication errors. The invention includes a chamber that is substantially transmissive of ultraviolet radiation that is unaffected by ambient light in a clinical setting, even with a spectroscopic reader that functions in an unshielded configuration.The problem of medication errors has been well documented. ...

A Sample Holder for Imaging a Plurality of Samples

A sample holder comprises one or more elongated sample tubes. The one or more elongated sample tubes are adapted for accommodating a plurality of samples to be imaged at an imaging position. The imaging position is defined by at least one illumination objective lens and at least one detection objective lens of a microscope. A microscope is disclosed, comprising at least one illumination objective lens and at least one detection objective lens, which define an imaging position. The microscope further comprises a sample holder for holding a plurality of samples. The sample holder is moveable with respect to the imaging position. A method for imaging a plurality of samples by means of the microscope is disclosed.

Lamp Temperature Management Systems and Methods for Liquid Chromatography Analyzers

A liquid sample analyzer includes a flow cell, a light source, and a lamp temperature management system. The flow cell is configured to receive a flow of a liquid sample from a liquid sample source. The light source includes a lamp configured to emit light to illuminate the flow of the liquid sample in the flow cell. The lamp temperature management system includes: an air flow generator operable to generate a turbulent air flow to cool the lamp; a thermally conductive primary housing encapsulating the lamp such that a primary air gap is provided between the primary housing and the lamp; and a thermally conductive secondary housing surrounding the primary housing and configured to deflect the turbulent air flow away from the primary housing. 1. A liquid sample analyzer comprising:a flow cell configured to receive a flow of a liquid sample from a liquid sample source;a light source including a lamp configured to emit light to illuminate the flow of the liquid sample in the flow cell; and an air flow generator operable to generate a turbulent air flow to cool the lamp;', 'a thermally conductive primary housing encapsulating the lamp such that a primary air gap is provided between the primary housing and the lamp; and', 'a thermally conductive secondary housing surrounding the primary housing and configured to deflect the turbulent air flow away from the primary housing., 'a lamp temperature management system including2. The liquid sample analyzer of wherein the primary housing defines a lamp chamber containing the lamp and the lamp chamber is fluidly sealed from the exterior of the primary housing.3. The liquid sample analyzer of including a buffer chamber defined by and between the primary housing and the secondary housing.4. The liquid sample analyzer of wherein the primary housing includes thermal fins extending into the buffer chamber to facilitate heat transfer from the lamp chamber to the buffer chamber.5. The liquid sample analyzer of wherein the buffer chamber ...

FLAME DETECTOR FIELD OF VIEW VERIFICATION VIA REVERSE INFRARED SIGNALING

Embodiments relate generally to systems, devices, and methods for verifying operation of an optical flame detector. A system may comprise an optical flame detector, wherein the optical flame detector comprises: a digital infrared test signal source, wherein the digital infrared test signal source is configured to transmit a digital infrared test signal; and at least one of an ultraviolet light sensor, a visible light sensor, and an infrared sensor; and an portable infrared test receiver, wherein the digital infrared test signal is receivable by the portable infrared test receiver, wherein the portable infrared test receiver is positioned to indicate whether a location of potential fire is within a field of view of the optical flame detector. 1. An optical flame detector comprising: ["a digital infrared test signal source, wherein the digital infrared test signal source is configured to transmit a digital infrared test signal, wherein the digital infrared test signal comprises at least one of: a serial number of the optical flame detector, a user's mnemonic name, sensor sensitivity, time since a last reboot of the optical flame detector, a real time clock value of the optical flame detector, and current analog optical signal levels; and", 'at least one of an ultraviolet light sensor, a visible light sensor, and an infrared sensor., 'a housing, wherein the housing comprises2. The optical flame detector of claim 1 , wherein the digital infrared test signal source is configured to transmit a digital infrared test signal at an angle ranging from about 100° to about 170° relative to an x-axis claim 1 , a y-axis claim 1 , or a z-axis.3. The optical flame detector of claim 2 , wherein a transmitting range for the digital infrared test signal source is about 0 meters to about 60 meters.4. The optical flame detector of claim 3 , wherein a transmission frequency of the digital infrared test signal is from about 30 kilohertz to about 60 kilohertz.5. The optical flame detector ...

UNIVERSAL SAMPLE HOLDER

This device is for holding samples during their preparation prior to imaging in the electron microscope. The design means it can be transferred between the light and electron microscopes as well as trimming devices used to prepare the final sample. It can also be used at both ambient and cryo temperatures down to −110° C. The device consists of a base plate that can be held on the stage of a light microscope. It has an aperture through which transmitted light can pass. In this aperture is a clamp which holds a small transparent plastic sphere; the sample sphere. The sample for preparation is bonded to this sphere. The shape of this clamp and sphere means that the sample can be held at any angle to allow for optimal imaging in any light microscope and in the trimming devices, including the ultramicrotome. Once trimmed, the entire universal sample holder can then be transferred into the scanning electron microscope, or held in the ultramicrotome for thin sectioning. 1. A sample holder for visualizing biological samples comprising a removable support including at least one contact surface adapted to be in contact with a sample or an embedded sample;characterized by the fact that said removable support is a transparent sphere.2. The sample holder according to wherein the sphere diameter is comprised between 3 and 6 mm.3. The sample holder according to wherein said contact surface is a first flattened portion located on one side of the sphere.4. The sample holder according to wherein said sphere comprises a second flattened portion claim 3 , located on a side of the sphere which is opposite with respect to said contact surface.5. The sample holder according to wherein each flattened portion is approximately 1 mm wide.6. The sample holder according to wherein the sphere is rotatable.7. The sample holder according to comprising clamping means adapted to hold the sphere.8. The sample holder according to wherein said clamping means comprise locking means claim 7 , for ...