06-02-2020 дата публикации
Номер: US20200041502A1
The present disclosure relates to magnetic particles, wherein each particle has a polymer matrix and at least one magnetic core (M), wherein the polymer matrix has at least one crosslinked polymer and wherein the magnetic particle has a particle size in the range of from 1 to 60 micrometer. Further, the present disclosure relates to a method of preparing such particles, and to particles obtainable or obtained by said method. Moreover, the present disclosure uses these magnetic particles for qualitative and/or quantitative determination of at least one analyte in a fluid. Further, the present disclosure relates to a method for determining at least one analyte in a fluid sample using the contacting of a magnetic particle of the disclosure or a magnetic particle obtained by the method of the present disclosure with a fluid sample having or suspected to have the at least one analyte. 1. Magnetic particle comprising a polymer matrix (P) and at least one magnetic core (M) , wherein the polymer matrix comprises a hypercrosslinked polymer and wherein the magnetic particle has a particle size in the range of from 5 to 40 micrometers , as determined according to ISO 13320;{'sub': 2', '2', '2', '2', '3', '3', '2', '5', '4', '9', '8', '17', '18', '37', '6', '5', '6', '9', '6, 'sup': '+', 'wherein the surface of the particle is functionalized with at least one group selected from the group consisting of —OH, —COOH, diethylaminoethanol, R—SO—OH, —NH, R—SO—OH, —RNH, —RN, —RN—CH, —CH, —CH, —CH, —CH, —CH, CHNOPhenyl-Hexyl, Bi-Phenyl, Hydroxyapatit, boronic acid, biotin, azide, epoxide, alkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, aminoacids, —COOR, —COR, —OR, antibodies and fragments thereof, aptameres, nucleic acids, and receptor proteins or binding domains thereof.'}2. The magnetic particle of claim 1 , wherein the polymer matrix comprises pores having a pore size smaller than 100 nm claim 1 , as determined according to ISO 15901-3.3. The magnetic particle of claim 2 , ...
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