31-03-2022 дата публикации
Номер: US20220096352A1
The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal. 1. Base-treated , detergent-treated telopeptide collagen.2. The collagen of that is mammalian collagen.3. The collagen of that is bovine claim 1 , ovine or rat collagen.4. The collagen of that is human collagen.5. The collagen of that is placental collagen.6. The collagen of that is human placental collagen.7. The collagen of that is cross-linked.8. The collagen of that is cross-linked with glutaraldehyde.9. Detergent-treated telopeptide collagen comprising a detectable amount of fibronectin.10. The composition of or comprising a plurality of stem cells.11. The composition of wherein the stem cells are embryonic stem cells claim 10 , embryonic germ cells claim 10 , mesenchymal stem cells claim 10 , bone marrow-derived stem cells claim 10 , hematopoietic stem cells from peripheral blood claim 10 , hematopoietic stem cells from fetal blood claim 10 , hematopoietic stem cells from placental blood claim 10 , hematopoietic stem cells from umbilical cord blood claim 10 , hematopoietic stem cells from placental perfusate claim 10 , somatic stem cells claim 10 , neural stem cells claim 10 , hepatic stem cells claim 10 , pancreatic stem cells claim 10 , endothelial stem cells claim 10 , cardiac stem cells claim 10 , muscle stem cells claim 10 , adipose stem cells claim 10 , or CD34 placental stem cells.12. The composition of wherein said CD34 placental stem cells are CD200.13. The composition of wherein said CD34 placental stem cells are:{'sup': +', '+, 'a. CD200 or HLA-G;'}{'sup': +', '+', '+, 'b. CD73, CD105, and CD200;'}{'sup': +', '+, 'c. CD200 and OCT-4;'}{'sup': +', '+', '+', '+', '+, 'd. CD73, CD105 and HLA-G, CD73 and CD105, and, when in a population of placental cells, ...
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