11-02-2016 дата публикации
Номер: US20160043774A1
Принадлежит:
In its many embodiments, the present invention provides certain C2-ring-substituted thiadiazine compounds, including compounds Formula (I): (structure represented) or tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R, R, ring A, R, m, -L-, R, and ring C are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed. 3. A compound of claim 2 , or a tautomer thereof claim 2 , or a pharmaceutically acceptable salt of said compound or said tautomer claim 2 , wherein:ring A is selected from the group consisting of phenyl, pyridazinyl, pyridyl, pyrimidinyl, pyrazinyl, triazinyl, and tetrazinyl;m is 0, 1, or 2; and{'sup': 'A', 'sub': 5', '3', '3', '2', '3', '2', '3', '2', '2', '3', '3', '2', '3', '2', '2', '3', '2, 'each R(when present) is independently selected from the group consisting of halogen, oxo, —CN, —SF, —NHCH, —N(CH), —OCH, —OCHCH, —O-cyclopropyl, —O—CH-cyclopropyl, —CHOCH, —S(CH), methyl, ethyl, cyclopropyl, —CH-cyclopropyl, —CF, —CHF, —CHF, —OCF, and —OCHF.'}4. A compound of claim 3 , or a tautomer thereof claim 3 , or a pharmaceutically acceptable salt of said compound or said tautomer claim 3 , wherein:{'sup': 'L', 'sub': 3', '2', '2', '2', '3', '2', '3', '2', '3', '2', '2', '3', '2', '2', '3', '2', '3', '2', '2', '3', '2', '2', '3', '2', '3', '2', '2', '3', '2', '2', '3', '2', '2', '3', '2', '2, 'Ris selected from the group consisting of methyl, ethyl, propyl, butyl, —CF, —CHF, —CHF, —CHCF, —CFCH, —CHOCH, —CHOCHCH, —CHCHOCH, —CHSCH, —CHSCHCH, —CHCHSCH, —CHN(CH), —CHNHCH, —CHCHN(CH), —CHOCF, and —CHOCHF.'}9. A pharmaceutical composition comprising a ...
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