09-06-2023 дата публикации
Номер: CN116239481A
Принадлежит:
The invention discloses a purification method of sphingamine, which comprises the following steps: adding impurity-containing sphingamine into methanol, heating and dissolving to obtain a mixed solution; adding dichloromethane into the mixed solution, cooling to 10-25 DEG C, and crystallizing; after the crystallization is finished, filtering, washing and drying in vacuum to obtain purified sphingamine; according to the purification method disclosed by the invention, the sphingamine is purified by adopting a common industrial crystallization means, and the method is easy to industrialize, low in energy consumption and controllable in product quality; besides, through screening of a large number of crystallization solvent systems, a crystallization system, particularly a methanol and dichloromethane crystallization system, having an impurity removal effect on the sphingamine compound is finally screened out, the purity of the sphingamine purified by the crystallization system is improved ...
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